
                                SEQUENCE LISTING

<110> Fred Hutchinson Cancer Research Center
      Perret, Rachel
      Greenberg, Philip D.

<120> CYCLIN A1 SPECIFIC T CELL RECEPTORS AND USES THEREOF
  
<130> 360056.460WO

<140> PCT                 
<141> 2019-02-12  

<150> US 62/667,207
<151> 2018-05-04

<150> US 62/630,198
<151> 2018-02-13

<150> US 62/629,648
<151> 2018-02-12

<160> 190

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> CCNA1 227-235 peptide

<400> 1
Phe Leu Asp Arg Phe Leu Ser Cys Met
 1               5

<210> 2
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> CCNA1 341-351 peptide

<400> 2
Ser Leu Ile Ala Ala Ala Ala Phe Cys Leu Ala
 1               5                  10

<210> 3
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> CCNA1 370-379 peptide

<400> 3
Tyr Ser Leu Ser Glu Ile Val Pro Cys Leu
 1               5                  10

<210> 4
<211> 421
<212> PRT
<213> Homo sapiens

<220> 
<223> CCNA1 protein isoform 3

<400> 4
Met His Cys Ser Asn Pro Lys Ser Gly Val Val Leu Ala Thr Val Ala
 1               5                  10                  15
Arg Gly Pro Asp Ala Cys Gln Ile Leu Thr Arg Ala Pro Leu Gly Gln
            20                  25                  30
Asp Pro Pro Gln Arg Thr Val Leu Gly Leu Leu Thr Ala Asn Gly Gln
        35                  40                  45
Tyr Arg Arg Thr Cys Gly Gln Gly Ile Thr Arg Ile Arg Cys Tyr Ser
    50                  55                  60
Gly Ser Glu Asn Ala Phe Pro Pro Ala Gly Lys Lys Ala Leu Pro Asp
65                  70                  75                  80
Cys Gly Val Gln Glu Pro Pro Lys Gln Gly Phe Asp Ile Tyr Met Asp
                85                  90                  95
Glu Leu Glu Gln Gly Asp Arg Asp Ser Cys Ser Val Arg Glu Gly Met
            100                 105                 110
Ala Phe Glu Asp Val Tyr Glu Val Asp Thr Gly Thr Leu Lys Ser Asp
        115                 120                 125
Leu His Phe Leu Leu Asp Phe Asn Thr Val Ser Pro Met Leu Val Asp
    130                 135                 140
Ser Ser Leu Leu Ser Gln Ser Glu Asp Ile Ser Ser Leu Gly Thr Asp
145                 150                 155                 160
Val Ile Asn Val Thr Glu Tyr Ala Glu Glu Ile Tyr Gln Tyr Leu Arg
                165                 170                 175
Glu Ala Glu Ile Arg His Arg Pro Lys Ala His Tyr Met Lys Lys Gln
            180                 185                 190
Pro Asp Ile Thr Glu Gly Met Arg Thr Ile Leu Val Asp Trp Leu Val
        195                 200                 205
Glu Val Gly Glu Glu Tyr Lys Leu Arg Ala Glu Thr Leu Tyr Leu Ala
    210                 215                 220
Val Asn Phe Leu Asp Arg Phe Leu Ser Cys Met Ser Val Leu Arg Gly
225                 230                 235                 240
Lys Leu Gln Leu Val Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Tyr
                245                 250                 255
Glu Glu Ile Tyr Pro Pro Glu Val Asp Glu Phe Val Tyr Ile Thr Asp
            260                 265                 270
Asp Thr Tyr Thr Lys Arg Gln Leu Leu Lys Met Glu His Leu Leu Leu
        275                 280                 285
Lys Val Leu Ala Phe Asp Leu Thr Val Pro Thr Thr Asn Gln Phe Leu
    290                 295                 300
Leu Gln Tyr Leu Arg Arg Gln Gly Val Cys Val Arg Thr Glu Asn Leu
305                 310                 315                 320
Ala Lys Tyr Val Ala Glu Leu Ser Leu Leu Glu Ala Asp Pro Phe Leu
                325                 330                 335
Lys Tyr Leu Pro Ser Leu Ile Ala Ala Ala Ala Phe Cys Leu Ala Asn
            340                 345                 350
Tyr Thr Val Asn Lys His Phe Trp Pro Glu Thr Leu Ala Ala Phe Thr
        355                 360                 365
Gly Tyr Ser Leu Ser Glu Ile Val Pro Cys Leu Ser Glu Leu His Lys
    370                 375                 380
Ala Tyr Leu Asp Ile Pro His Arg Pro Gln Gln Ala Ile Arg Glu Lys
385                 390                 395                 400
Tyr Lys Ala Ser Lys Tyr Leu Cys Val Ser Leu Met Glu Pro Pro Ala
                405                 410                 415
Val Leu Leu Leu Gln
            420

<210> 5
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number5 Valpha CDR3

<400> 5
Cys Gly Thr Glu Glu Ala Asn Asp Tyr Lys Leu Ser Phe
 1               5                  10

<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number5 Vbeta CDR3

<400> 6
Cys Ala Ser Ser Val Gly Gln Gly Ser Ser Tyr Glu Gln Tyr Phe
 1               5                  10                  15

<210> 7
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 and TCR number 11 Valpha CDR3

<400> 7
Cys Val Val Trp Gly Gly Asp Thr Asp Lys Leu Ile Phe
 1               5                  10

<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 Vbeta CDR3

<400> 8
Cys Ala Ile Leu Asp Gly Glu Gly Ser Pro Leu His Phe
 1               5                  10

<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Valpha CDR3

<400> 9
Cys Ala Leu Gly Pro Tyr Asn Asp Tyr Lys Leu Ser Phe
 1               5                  10

<210> 10
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Vbeta CDR3

<400> 10
Cys Ala Ser Ser Asp Arg Ser Asn Thr Gly Glu Leu Phe Phe
 1               5                  10

<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 Valpha CDR3

<400> 11
Cys Ala Val Glu Gly Asp Ser Ser Tyr Lys Leu Ile Phe
 1               5                  10

<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 Vbeta CDR3

<400> 12
Cys Ala Ser Ser Phe Phe Ser Gln Glu Thr Gln Tyr Phe
 1               5                  10

<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 Valpha CDR3

<400> 13
Cys Ala Val Ile Gly Glu Gln Asn Phe Val Phe
 1               5                  10

<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 Vbeta CDR3

<400> 14
Cys Ala Ser Ser Leu Ser Gly Leu Gly Ser Gly Ala Asn Val Leu Thr
 1               5                  10                  15
Phe


<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Valpha CDR3

<400> 15
Cys Ala Val Asp Ser Gly Gly Tyr Gln Lys Val Thr Phe
 1               5                  10

<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Vbeta CDR3

<400> 16
Cys Ala Ser Ser Leu Asn Met Asn Thr Glu Ala Phe Phe
 1               5                  10

<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 Valpha CDR3

<400> 17
Cys Ala Thr Asp Glu Ser Ser Asn Tyr Lys Leu Thr Phe
 1               5                  10

<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 Vbeta CDR3

<400> 18
Cys Ala Ser Ser Leu Asn Met Asn Thr Glu Ala Phe Phe
 1               5                  10

<210> 19
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 Valpha CDR3

<400> 19
Cys Ala Thr Asp Ala Trp Glu Ser Asn Phe Gly Asn Glu Lys Leu Thr
 1               5                  10                  15
Phe


<210> 20
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 Vbeta CDR3

<400> 20
Cys Ala Ser Ser Leu Val Val Gly Ser Tyr Glu Gln Tyr Phe
 1               5                  10

<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Valpha CDR3

<400> 21
Cys Ala Tyr Leu Gly Ala Gly Asn Gln Phe Tyr Phe
 1               5                  10

<210> 22
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Vbeta CDR3

<400> 22
Cys Ala Ser Ser Leu Asn Arg Gly Arg Tyr Gly Tyr Thr Phe
 1               5                  10

<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Valpha CDR3

<400> 23
Cys Ala Leu Ser Glu Leu Ala Ser Gly Gly Ser Tyr Ile Pro Thr Phe
 1               5                  10                  15

<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Vbeta CDR3

<400> 24
Cys Ala Ser Ser Phe Arg Leu Ala Gly Gly Pro Ser Thr Asp Thr Gln
 1               5                  10                  15
Tyr Phe


<210> 25
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> P2A peptide encoding nucleic acid

<400> 25
ggttccggag ccacgaactt ctctctgtta aagcaagcag gagacgtgga agaaaacccc      60
ggtccc                                                                 66

<210> 26
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> T2A peptide encoding nucleic acid

<400> 26
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga      60
cct                                                                    63

<210> 27
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> E2A peptide encoding nucleic acid

<400> 27
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac      60
cctggacct                                                              69

<210> 28
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> F2A peptide encoding nucleic acid

<400> 28
ggaagcggag tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag      60
tccaaccctg gacct                                                       75

<210> 29
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A peptide

<400> 29
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15
Glu Glu Asn Pro Gly Pro
            20

<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A peptide

<400> 30
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15
Glu Asn Pro Gly Pro
            20

<210> 31
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2A peptide

<400> 31
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp
 1               5                  10                  15
Val Glu Ser Asn Pro Gly Pro
            20

<210> 32
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> F2A peptide

<400> 32
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25

<210> 33
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha constant domain polypeptide

<400> 33
Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
 1               5                  10                  15
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
            20                  25                  30
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
        35                  40                  45
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
    50                  55                  60
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
65                  70                  75                  80
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
                85                  90                  95
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
            100                 105                 110
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
        115                 120                 125
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 34
<211> 177
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta1 constant domain polypeptide

<400> 34
Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro
 1               5                  10                  15
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu
            20                  25                  30
Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn
        35                  40                  45
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys
    50                  55                  60
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu
65                  70                  75                  80
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys
                85                  90                  95
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp
            100                 105                 110
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg
        115                 120                 125
Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser
    130                 135                 140
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala
145                 150                 155                 160
Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp
                165                 170                 175
Phe


<210> 35
<211> 1821
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 5 construct; beta chain-P2A-alpha chain

<400> 35
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat      60
tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg     120
agatgctccc ctaggtctgg agacctctct gtgtactggt accaacagag cctggaccag     180
ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt     240
gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg     300
gagctggggg actcagcttt gtatttctgt gccagcagcg tagggcaggg gtcctcctac     360
gagcagtact tcgggccggg caccaggctc acggtcacag aggacctgaa aaacgtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacctgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg     900
ctgatggcca tggtcaagag aaaggattcc agaggcggtt ccggagccac gaacttctct     960
ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatggagac tctcctgaaa    1020
gtgctttcag gcaccttgtt gtggcagttg acctgggtga gaagccaaca accagtgcag    1080
agtcctcaag ccgtgatcct ccgagaaggg gaagatgctg tcatcaactg cagttcctcc    1140
aaggctttat attctgtaca ctggtacagg cagaagcatg gtgaagcacc cgtcttcctg    1200
atgatattac tgaagggtgg agaacagaag ggtcatgaaa aaatatctgc ttcatttaat    1260
gaaaaaaagc agcaaagctc cctgtacctt acggcctccc agctcagtta ctcaggaacc    1320
tacttctgcg gcacagagga agctaacgac tacaagctca gctttggagc cggaaccaca    1380
gtaactgtaa gagcaaatat ccagaaccct gaccctgccg tgtaccagct gagagactct    1440
aaatccagtg acaagtctgt ctgcctattc accgattttg attctcaaac aaatgtgtca    1500
caaagtaagg attctgatgt gtatatcaca gacaaaactg tgctagacat gaggtctatg    1560
gacttcaaga gcaacagtgc tgtggcctgg agcaacaaat ctgactttgc atgtgcaaac    1620
gccttcaaca acagcattat tccagaagac accttcttcc ccagcccaga aagttcctgt    1680
gatgtcaagc tggtcgagaa aagctttgaa acagatacga acctaaactt tcaaaacctg    1740
tcagtgattg ggttccgaat cctcctcctg aaagtggccg ggtttaatct gctcatgacg    1800
ctgcggctgt ggtccagctg a                                              1821

<210> 36
<211> 606
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 construct; beta chain-P2A-alpha chain

<400> 36
Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr
            20                  25                  30
Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp
        35                  40                  45
Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe
    50                  55                  60
Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu
65                  70                  75                  80
Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn
                85                  90                  95
Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Val Gly Gln Gly Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser
305                 310                 315                 320
Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu
                325                 330                 335
Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu Thr Trp
            340                 345                 350
Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile Leu Arg
        355                 360                 365
Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala Leu Tyr
    370                 375                 380
Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val Phe Leu
385                 390                 395                 400
Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys Ile Ser
                405                 410                 415
Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu Thr Ala
            420                 425                 430
Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Glu Glu Ala
        435                 440                 445
Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg
    450                 455                 460
Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
465                 470                 475                 480
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
                485                 490                 495
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
            500                 505                 510
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
        515                 520                 525
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
    530                 535                 540
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
545                 550                 555                 560
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
                565                 570                 575
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
            580                 585                 590
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 37
<211> 1493
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 5 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 37
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgggcttc agactgttgt      60
gttgcgtggc cttttgcctt cttggagctg gacctgtgga ttctggagtt acacagaccc     120
ctaagcacct gattacagcc acaggacaga gagtgaccct gagatgtagc cctagaagcg     180
gagatctgag cgtgtattgg taccagcaga gcctggatca aggactccag tttctgatcc     240
agtactacaa cggcgaggag agagccaagg gcaatattct ggagaggttt tctgcccagc     300
agttccctga tctgcactct gaactgaacc tgtctagcct ggaactggga gattctgccc     360
tgtacttttg tgcctctagc gttggacagg gcagctctta tgagcagtac tttggacctg     420
gcaccagact gacagtgaca gaagacctga agaacgtgtt ccccccagag gtggccgtgt     480
tcgagcctag cgaggccgag atcagccaca cccagaaagc caccctcgtg tgcctggcca     540
ccggctttta ccccgaccac gtggaactgt cttggtgggt caacggcaaa gaggtgcaca     600
gcggcgtctg caccgacccc cagcccctga aagagcagcc cgccctgaac gacagccggt     660
actgtctgag cagcagactg agagtgtccg ccaccttctg gcagaacccc cggaaccact     720
tcagatgcca ggtgcagttc tacggcctga gcgagaacga cgagtggacc caggaccggg     780
ccaagcccgt gacccagatc gtgtctgctg aggcctgggg cagagccgat tgcggcttca     840
ccagcgagag ctaccagcag ggcgtgctga gcgccaccat cctgtacgag atcctgctgg     900
gcaaggccac cctgtacgcc gtgctggtgt ccgccctggt gctgatggcc atggtcaagc     960
ggaaggacag ccggggcggt tccggagcca cgaacttctc tctgttaaag caagcaggag    1020
acgtggaaga aaaccccggt cccatggaaa ccctgctgaa agtgctgagc ggaacactgt    1080
tatggcagct tacatgggtg aggtctcagc aacctgtgca atctccacag gccgttatcc    1140
tgagagaagg agaagatgcc gtgatcaact gctctagctc taaagccctg tacagcgtgc    1200
actggtacag acagaaacac ggagaagctc ccgtgttcct gatgattctg ctgaaaggag    1260
gcgagcagaa gggacacgag aagatttctg ccagcttcaa cgagaagaag cagcagtcta    1320
gcctgtacct gacagcttct cagctgagct atagcggcac ctacttttgt ggcacagagg    1380
aagccaacga ctacaaactg agctttggag ccggcacaac agtgacagtt agagccaata    1440
tccagaaccc cgatcctgct gtgtaccagc tgcgggacag caagagcagc gac           1493

<210> 38
<211> 495
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 5 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 38
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Gly Phe Arg Leu
 1               5                  10                  15
Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala Gly Pro Val Asp Ser
            20                  25                  30
Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr Ala Thr Gly Gln Arg
        35                  40                  45
Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp Leu Ser Val Tyr Trp
    50                  55                  60
Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile Gln Tyr Tyr
65                  70                  75                  80
Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu Glu Arg Phe Ser Ala
                85                  90                  95
Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn Leu Ser Ser Leu Glu
            100                 105                 110
Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Val Gly Gln Gly
        115                 120                 125
Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
    130                 135                 140
Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro
145                 150                 155                 160
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu
                165                 170                 175
Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn
            180                 185                 190
Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys
        195                 200                 205
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu
    210                 215                 220
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys
225                 230                 235                 240
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp
                245                 250                 255
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg
            260                 265                 270
Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser
        275                 280                 285
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala
    290                 295                 300
Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp
305                 310                 315                 320
Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala
                325                 330                 335
Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Leu Leu Lys Val
            340                 345                 350
Leu Ser Gly Thr Leu Leu Trp Gln Leu Thr Trp Val Arg Ser Gln Gln
        355                 360                 365
Pro Val Gln Ser Pro Gln Ala Val Ile Leu Arg Glu Gly Glu Asp Ala
    370                 375                 380
Val Ile Asn Cys Ser Ser Ser Lys Ala Leu Tyr Ser Val His Trp Tyr
385                 390                 395                 400
Arg Gln Lys His Gly Glu Ala Pro Val Phe Leu Met Ile Leu Leu Lys
                405                 410                 415
Gly Gly Glu Gln Lys Gly His Glu Lys Ile Ser Ala Ser Phe Asn Glu
            420                 425                 430
Lys Lys Gln Gln Ser Ser Leu Tyr Leu Thr Ala Ser Gln Leu Ser Tyr
        435                 440                 445
Ser Gly Thr Tyr Phe Cys Gly Thr Glu Glu Ala Asn Asp Tyr Lys Leu
    450                 455                 460
Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala Asn Ile Gln Asn
465                 470                 475                 480
Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
                485                 490                 495

<210> 39
<211> 1813
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 11 construct; beta chain-P2A-alpha
      chain

<400> 39
atgggcacca ggctcttctt ctatgtggcc ctttgtctgc tgtgggcagg acacagggat      60
gctggaatca cccagagccc aagatacaag atcacagaga caggaaggca ggtgaccttg     120
atgtgtcacc agacttggag ccacagctat atgttctggt atcgacaaga cctgggacat     180
gggctgaggc tgatctatta ctcagcagct gctgatatta cagataaagg agaagtcccc     240
gatggctatg ttgtctccag atccaagaca gagaatttcc ccctcactct ggagtcagct     300
acccgctccc agacatctgt gtatttctgc gccagcagtg acgggggcgg gcagtacttc     360
gggccgggca ccaggctcac ggtcacagag gacctgaaaa acgtgttccc acccgaggtc     420
gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc     480
ctggccacag gcttctaccc cgaccacgtg gagctgagct ggtgggtgaa tgggaaggag     540
gtgcacagtg gggtcagcac agacccgcag cccctcaagg agcagcccgc cctcaatgac     600
tccagatact gcctgagcag ccgcctgagg gtctcggcca ccttctggca gaacccccgc     660
aaccacttcc gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag     720
gatagggcca aacctgtcac ccagatcgtc agcgccgagg cctggggtag agcagactgt     780
ggcttcacct ccgagtctta ccagcaaggg gtcctgtctg ccaccatcct ctatgagatc     840
ttgctaggga aggccacctt gtatgccgtg ctggtcagtg ccctcgtgct gatggccatg     900
gtcaagagaa aggattccag aggcggttcc ggagccacga acttctctct gttaaagcaa     960
gcaggagacg tggaagaaaa ccccggtccc atgaaaaagc atctgacgac cttcttggtg    1020
attttgtggc tttattttta tagggggaat ggcaaaaacc aagtggagca gagtcctcag    1080
tccctgatca tcctggaggg aaagaactgc actcttcaat gcaattatac agtgagcccc    1140
ttcagcaact taaggtggta taagcaagat actgggagag gtcctgtttc cctgacaatc    1200
atgactttca gtgagaacac aaagtcgaac ggaagatata cagcaactct ggatgcagac    1260
acaaagcaaa gctctctgca catcacagcc tcccagctca gcgattcagc ctcctacatc    1320
tgtgtggtgt ggggggggga caccgacaag ctcatctttg ggactgggac cagattacaa    1380
gtctttccaa atatccagaa ccctgaccct gccgtgtacc agctgagaga ctctaaatcc    1440
agtgacaagt ctgtctgcct attcaccgat tttgattctc aaacaaatgt gtcacaaagt    1500
aaggattctg atgtgtatat cacagacaaa actgctagac atgaggtcta tggacttcaa    1560
gagcaacagt gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa    1620
caacagcatt attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa    1680
gctggtcgag aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat    1740
tgggttccga atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct    1800
gtggtccagc tga                                                       1813

<210> 40
<211> 531
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 11 construct; beta chain-P2A-alpha
      chain

<400> 40
Met Gly Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Ala
 1               5                  10                  15
Gly His Arg Asp Ala Gly Ile Thr Gln Ser Pro Arg Tyr Lys Ile Thr
            20                  25                  30
Glu Thr Gly Arg Gln Val Thr Leu Met Cys His Gln Thr Trp Ser His
        35                  40                  45
Ser Tyr Met Phe Trp Tyr Arg Gln Asp Leu Gly His Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Ala Ala Ala Asp Ile Thr Asp Lys Gly Glu Val Pro
65                  70                  75                  80
Asp Gly Tyr Val Val Ser Arg Ser Lys Thr Glu Asn Phe Pro Leu Thr
                85                  90                  95
Leu Glu Ser Ala Thr Arg Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Asp Gly Gly Gly Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val
        115                 120                 125
Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu
    130                 135                 140
Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys
145                 150                 155                 160
Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val
                165                 170                 175
Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu
            180                 185                 190
Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg
        195                 200                 205
Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg
    210                 215                 220
Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln
225                 230                 235                 240
Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly
                245                 250                 255
Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu
            260                 265                 270
Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr
        275                 280                 285
Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys
    290                 295                 300
Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln
305                 310                 315                 320
Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Lys His Leu Thr
                325                 330                 335
Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly Lys
            340                 345                 350
Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly Lys
        355                 360                 365
Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn Leu
    370                 375                 380
Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr Ile
385                 390                 395                 400
Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala Thr
                405                 410                 415
Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser Gln
            420                 425                 430
Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Trp Gly Gly Asp Thr
        435                 440                 445
Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn
    450                 455                 460
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
465                 470                 475                 480
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
                485                 490                 495
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Ala
            500                 505                 510
Arg His Glu Val Tyr Gly Leu Gln Glu Gln Gln Cys Cys Gly Leu Glu
        515                 520                 525
Gln Gln Ile
    530

<210> 41
<211> 1484
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 11 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 41
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgggcaca cggcttttct      60
tctacgttgc cctttgcctg ctgtgggctg gacatagaga tgctggaatc acacagagcc     120
ccaggtacaa gatcacagag acaggaagac aggtgaccct gatgtgtcac caaacatgga     180
gccacagcta catgttctgg tacagacagg atctgggaca cggactgaga ctgatctact     240
attctgctgc cgccgacatc accgataaag gagaagttcc tgacggctac gtggtgtcta     300
gaagcaaaac cgagaacttc cccctgacac tggaatctgc cacaagatct cagaccagcg     360
tgtacttttg cgcctcttct gatggaggag gccagtattt tccaggcaca agactgacag     420
tgaccgagga cctgaagaac gtgttccccc cagaggtggc cgtgttcgag cctagcgagg     480
ccgagatcag ccacacccag aaagccaccc tcgtgtgcct ggccaccggc ttttaccccg     540
accacgtgga actgtcttgg tgggtcaacg gcaaagaggt gcacagcggc gtctgcaccg     600
acccccagcc cctgaaagag cagcccgccc tgaacgacag ccggtactgt ctgagcagca     660
gactgagagt gtccgccacc ttctggcaga acccccggaa ccacttcaga tgccaggtgc     720
agttctacgg cctgagcgag aacgacgagt ggacccagga ccgggccaag cccgtgaccc     780
agatcgtgtc tgctgaggcc tggggcagag ccgattgcgg cttcaccagc gagagctacc     840
agcagggcgt gctgagcgcc accatcctgt acgagatcct gctgggcaag gccaccctgt     900
acgccgtgct ggtgtccgcc ctggtgctga tggccatggt caagcggaag gacagccggg     960
gcggttccgg agccacgaac ttctctctgt taaagcaagc aggagacgtg gaagaaaacc    1020
ccggtcccat gaagaagcac ctgaccacgt tcctggtgat tctttggctg tacttctacc    1080
ggggcaacgg caaaaatcag gtggaacaaa gcccccagag cctgattatt ctggagggca    1140
agaactgcac cctccagtgt aattacaccg tgagcccttt cagcaacctg agatggtaca    1200
agcaggatac cggaagagga cctgtgtctc tgaccatcat gacctttagc gagaacacca    1260
agagcaacgg caggtataca gccacactgg atgccgatac caagcagtct tctctgcaca    1320
ttaccgcctc tcagctgtct gattctgcca gctacatctg tgtggtgtgg ggaggagata    1380
ccgataagct gatctttggc acaggcacca gactgcaagt gttccctaac atccagaacc    1440
ctgatcctgc cgtgtaccag ctgcgggaca gcaagagcag cgac                     1484

<210> 42
<211> 492
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 11 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 42
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Gly Thr Arg Leu
 1               5                  10                  15
Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Ala Gly His Arg Asp Ala
            20                  25                  30
Gly Ile Thr Gln Ser Pro Arg Tyr Lys Ile Thr Glu Thr Gly Arg Gln
        35                  40                  45
Val Thr Leu Met Cys His Gln Thr Trp Ser His Ser Tyr Met Phe Trp
    50                  55                  60
Tyr Arg Gln Asp Leu Gly His Gly Leu Arg Leu Ile Tyr Tyr Ser Ala
65                  70                  75                  80
Ala Ala Asp Ile Thr Asp Lys Gly Glu Val Pro Asp Gly Tyr Val Val
                85                  90                  95
Ser Arg Ser Lys Thr Glu Asn Phe Pro Leu Thr Leu Glu Ser Ala Thr
            100                 105                 110
Arg Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Asp Gly Gly Gly
        115                 120                 125
Gln Tyr Phe Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn
    130                 135                 140
Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile
145                 150                 155                 160
Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr
                165                 170                 175
Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His
            180                 185                 190
Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu
        195                 200                 205
Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr
    210                 215                 220
Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr
225                 230                 235                 240
Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val
                245                 250                 255
Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe
            260                 265                 270
Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr
        275                 280                 285
Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala
    290                 295                 300
Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser
305                 310                 315                 320
Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu
                325                 330                 335
Asn Pro Gly Pro Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu
            340                 345                 350
Trp Leu Tyr Phe Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser
        355                 360                 365
Pro Gln Ser Leu Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys
    370                 375                 380
Asn Tyr Thr Val Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp
385                 390                 395                 400
Thr Gly Arg Gly Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn
                405                 410                 415
Thr Lys Ser Asn Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys
            420                 425                 430
Gln Ser Ser Leu His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser
        435                 440                 445
Tyr Ile Cys Val Val Trp Gly Gly Asp Thr Asp Lys Leu Ile Phe Gly
    450                 455                 460
Thr Gly Thr Arg Leu Gln Val Phe Pro Asn Ile Gln Asn Pro Asp Pro
465                 470                 475                 480
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
                485                 490

<210> 43
<211> 828
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 6 alpha chain

<400> 43
atggagaaga atcctttggc agccccatta ctaatcctct ggtttcatct tgactgcgtg      60
agcagcatac tgaacgtgga acaaagtcct cagtcactgc atgttcagga gggagacagc     120
accaatttca cctgcagctt cccttccagc aatttttatg ccttacactg gtacagatgg     180
gaaactgcaa aaagccccga ggccttgttt gtaatgactt taaatgggga tgaaaagaag     240
aaaggacgaa taagtgccac tcttaatacc aaggagggtt acagctattt gtacatcaaa     300
ggatcccagc ctgaagactc agccacatac ctctgtgcct tagggcctta taacgactac     360
aagctcagct ttggagccgg aaccacagta actgtaagag caaatatcca gaaccctgac     420
cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc     480
gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac     540
aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc     600
aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc     660
ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca     720
gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa     780
gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctga                  828

<210> 44
<211> 275
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 alpha chain

<400> 44
Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His
 1               5                  10                  15
Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser
            20                  25                  30
Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro
        35                  40                  45
Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys
    50                  55                  60
Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys
65                  70                  75                  80
Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr
                85                  90                  95
Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys
            100                 105                 110
Ala Leu Gly Pro Tyr Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr
        115                 120                 125
Thr Val Thr Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
    130                 135                 140
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
145                 150                 155                 160
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
                165                 170                 175
Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys
            180                 185                 190
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
        195                 200                 205
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
    210                 215                 220
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
225                 230                 235                 240
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
                245                 250                 255
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
            260                 265                 270
Trp Ser Ser
        275

<210> 45
<211> 936
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 6 beta chain

<400> 45
atgagcatca gcctcctgtg ctgtgcagcc tttcctctcc tgtgggcagg tccagtgaat      60
gctggtgtca ctcagacccc aaaattccgc atcctgaaga taggacagag catgacactg     120
cagtgtaccc aggatatgaa ccataactac atgtactggt atcgacaaga cccaggcatg     180
gggctgaagc tgatttatta ttcagttggt gctggtatca ctgataaagg agaagtcccg     240
aatggctaca acgtctccag atcaaccaca gaggatttcc cgctcaggct ggagttggct     300
gctccctccc agacatctgt gtacttctgt gccagcagtg acaggtctaa caccggggag     360
ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg     900
atggccatgg tcaagagaaa ggattccaga ggctag                               936

<210> 46
<211> 311
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 beta chain

<400> 46
Met Ser Ile Ser Leu Leu Cys Cys Ala Ala Phe Pro Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Ile Leu
            20                  25                  30
Lys Ile Gly Gln Ser Met Thr Leu Gln Cys Thr Gln Asp Met Asn His
        35                  40                  45
Asn Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Lys Leu
    50                  55                  60
Ile Tyr Tyr Ser Val Gly Ala Gly Ile Thr Asp Lys Gly Glu Val Pro
65                  70                  75                  80
Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg
                85                  90                  95
Leu Glu Leu Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Asp Arg Ser Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 47
<211> 1499
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 6 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 47
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgagcatc agcctcctgt      60
gctgtgcagc ctttcctctc ctgtgggcag gtccagtgaa tgctggtgtc actcagaccc     120
caaaattccg catcctgaag ataggacaga gcatgacact gcagtgtacc caggatatga     180
accataacta catgtactgg tatcgacaag acccaggcat ggggctgaag ctgatttatt     240
attcagttgg tgctggtatc actgataaag gagaagtccc gaatggctac aacgtctcca     300
gatcaaccac agaggatttc ccgctcaggc tggagttggc tgctccctcc cagacatctg     360
tgtacttctg tgccagcagt gacaggtcta acaccgggga gctgtttttt ggagaaggct     420
ctaggctgac cgtactggag gacctgaaaa acgtgttccc acccgaggtc gctgtgtttg     480
agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc ctggccacag     540
gcttctaccc cgaccacgtg gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg     600
gggtcagcac agacccgcag cccctcaagg agcagcccgc cctcaatgac tccagatact     660
gcctgagcag ccgcctgagg gtctcggcca ccttctggca gaacccccgc aaccacttcc     720
gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag gatagggcca     780
aacctgtcac ccagatcgtc agcgccgagg cctggggtag agcagactgt ggcttcacct     840
ccgagtctta ccagcaaggg gtcctgtctg ccaccatcct ctatgagatc ttgctaggga     900
aggccacctt gtatgccgtg ctggtcagtg ccctcgtgct gatggccatg gtcaagagaa     960
aggattccag aggcggttcc ggagccacga acttctctct gttaaagcaa gcaggagacg    1020
tggaagaaaa ccccggtccc atggagaaga atcctttggc agccccatta ctaatcctct    1080
ggtttcatct tgactgcgtg agcagcatac tgaacgtgga acaaagtcct cagtcactgc    1140
atgttcagga gggagacagc accaatttca cctgcagctt cccttccagc aatttttatg    1200
ccttacactg gtacagatgg gaaactgcaa aaagccccga ggccttgttt gtaatgactt    1260
taaatgggga tgaaaagaag aaaggacgaa taagtgccac tcttaatacc aaggagggtt    1320
acagctattt gtacatcaaa ggatcccagc ctgaagactc agccacatac ctctgtgcct    1380
tagggcctta taacgactac aagctcagct ttggagccgg aaccacagta actgtaagag    1440
caaatatcca gaaccctgac cctgccgtgt accagctgcg ggacagcaag agcagcgac     1499

<210> 48
<211> 1815
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 1 construct; beta chain-P2A-alpha chain

<400> 48
atgggccccg ggctcctctg ctgggcactg ctttgtctcc tgggagcagg cttagtggac      60
gctggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctc ctaagtctgg gcatgacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatgag gaggaagaga gacagagagg caacttccct     240
gatcgattct caggtcacca gttccctaac tatagctctg agctgaatgt gaacgccttg     300
ttgctggggg actcggccct ctatctctgt gccagcagct tcttcagcca agagacccag     360
tacttcgggc caggcacgcg gctcctggtg ctcgaggacc tgaaaaacgt gttcccaccc     420
gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg     480
gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg     540
aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc     600
aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     660
ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     720
acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca     780
gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat     840
gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg     900
gccatggtca agagaaagga ttccagaggc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatgg agaccctctt gggcctgctt    1020
atcctttggc tgcagctgca atgggtgagc agcaaacagg aggtgacaca gattcctgca    1080
gctctgagtg tcccagaagg agaaaacttg gttctcaact gcagtttcac tgatagcgct    1140
atttacaacc tccagtggtt taggcaggac cctgggaaag gtctcacatc tctgttgctt    1200
attcagtcaa gtcagagaga gcaaacaagt ggaagactta atgcctcgct ggataaatca    1260
tcaggacgta gtactttata cattgcagct tctcagcctg gtgactcagc cacctacctc    1320
tgtgccgtgg agggggatag cagctataaa ttgatcttcg ggagtgggac cagactgctg    1380
gtcaggcctg atatccagaa ccctgaccct gccgtgtacc agctgagaga ctctaaatcc    1440
agtgacaagt ctgtctgcct attcaccgat tttgattctc aaacaaatgt gtcacaaagt    1500
aaggattctg atgtgtatat cacagacaaa actgtgctag acatgaggtc tatggacttc    1560
aagagcaaca gtgctgtggc ctggagcaac aaatctgact ttgcatgtgc aaacgccttc    1620
aacaacagca ttattccaga agacaccttc ttccccagcc cagaaagttc ctgtgatgtc    1680
aagctggtcg agaaaagctt tgaaacagat acgaacctaa actttcaaaa cctgtcagtg    1740
attgggttcc gaatcctcct cctgaaagtg gccgggttta atctgctcat gacgctgcgg    1800
ctgtggtcca gctga                                                     1815

<210> 49
<211> 604
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 construct; beta chain-P2A-alpha chain

<400> 49
Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His
        35                  40                  45
Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro
65                  70                  75                  80
Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Phe Phe Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
305                 310                 315                 320
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Leu
                325                 330                 335
Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp Val Ser Ser Lys
            340                 345                 350
Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly Glu
        355                 360                 365
Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn Leu
    370                 375                 380
Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu Leu
385                 390                 395                 400
Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala Ser
                405                 410                 415
Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln
            420                 425                 430
Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Glu Gly Asp Ser Ser
        435                 440                 445
Tyr Lys Leu Ile Phe Gly Ser Gly Thr Arg Leu Leu Val Arg Pro Asp
    450                 455                 460
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
465                 470                 475                 480
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
                485                 490                 495
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val
            500                 505                 510
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
        515                 520                 525
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
    530                 535                 540
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
545                 550                 555                 560
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
                565                 570                 575
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
            580                 585                 590
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 50
<211> 1487
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 1 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 50
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgggacct ggactgcttt      60
gttgggctct tctgtgtctg cttggagctg gactggttga tgctggagtt acacagagcc     120
ctacacacct gatcaagaca agaggacagc aggtgaccct gagatgtagc cctaaatctg     180
gccacgatac cgtgagctgg tatcaacagg ctctgggaca aggacctcag ttcatcttcc     240
agtactacga ggaggaggag agacagagag gcaatttccc tgacaggttt agcggacacc     300
agttccccaa ttacagctct gagctgaacg tgaatgccct tcttctggga gattctgccc     360
tgtatctgtg tgccagcagc ttctttagcc aggaaaccca gtacttcggc ccaggaacaa     420
gactgctggt tcttgaagac ctgaagaacg tgttcccccc agaggtggcc gtgttcgagc     480
ctagcgaggc cgagatcagc cacacccaga aagccaccct cgtgtgcctg gccaccggct     540
tttaccccga ccacgtggaa ctgtcttggt gggtcaacgg caaagaggtg cacagcggcg     600
tctgcaccga cccccagccc ctgaaagagc agcccgccct gaacgacagc cggtactgtc     660
tgagcagcag actgagagtg tccgccacct tctggcagaa cccccggaac cacttcagat     720
gccaggtgca gttctacggc ctgagcgaga acgacgagtg gacccaggac cgggccaagc     780
ccgtgaccca gatcgtgtct gctgaggcct ggggcagagc cgattgcggc ttcaccagcg     840
agagctacca gcagggcgtg ctgagcgcca ccatcctgta cgagatcctg ctgggcaagg     900
ccaccctgta cgccgtgctg gtgtccgccc tggtgctgat ggccatggtc aagcggaagg     960
acagccgggg cggttccgga gccacgaact tctctctgtt aaagcaagca ggagacgtgg    1020
aagaaaaccc cggtcccatg gaaaccctgt taggcctgct cattctgtgg ttacagctcc    1080
aatgggtgag cagcaaacag gaagtgaccc agattcctgc tgccttatct gtgcctgaag    1140
gcgaaaatct ggtgctgaat tgcagcttca ccgattctgc catctacaac ctccagtggt    1200
tcagacagga tccaggaaaa ggcctgacat ctcttctgct gatccagtct agccagagag    1260
agcagacaag cggaagactg aatgcctctc tggacaagag cagcggaaga tctaccctgt    1320
atattgccgc ctctcagcct ggagattctg ccacatatct gtgtgccgtg gagggagata    1380
gcagctataa gctgatcttc ggcagcggca caagattact ggtgagacct gacatccaga    1440
accctgatcc tgctgtgtac cagctgcggg acagcaagag cagcgac                  1487

<210> 51
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 1 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 51
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Gly Pro Gly Leu
 1               5                  10                  15
Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala Gly Leu Val Asp Ala
            20                  25                  30
Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln
        35                  40                  45
Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His Asp Thr Val Ser Trp
    50                  55                  60
Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr
65                  70                  75                  80
Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro Asp Arg Phe Ser Gly
                85                  90                  95
His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Leu
            100                 105                 110
Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Phe Phe Ser Gln
        115                 120                 125
Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu Glu Asp
    130                 135                 140
Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu
145                 150                 155                 160
Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr
                165                 170                 175
Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys
            180                 185                 190
Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln
        195                 200                 205
Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val
    210                 215                 220
Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val
225                 230                 235                 240
Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala
                245                 250                 255
Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp
            260                 265                 270
Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr
        275                 280                 285
Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu
    290                 295                 300
Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg
305                 310                 315                 320
Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp
                325                 330                 335
Val Glu Glu Asn Pro Gly Pro Met Glu Thr Leu Leu Gly Leu Leu Ile
            340                 345                 350
Leu Trp Leu Gln Leu Gln Trp Val Ser Ser Lys Gln Glu Val Thr Gln
        355                 360                 365
Ile Pro Ala Ala Leu Ser Val Pro Glu Gly Glu Asn Leu Val Leu Asn
    370                 375                 380
Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn Leu Gln Trp Phe Arg Gln
385                 390                 395                 400
Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu Leu Ile Gln Ser Ser Gln
                405                 410                 415
Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala Ser Leu Asp Lys Ser Ser
            420                 425                 430
Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln Pro Gly Asp Ser Ala
        435                 440                 445
Thr Tyr Leu Cys Ala Val Glu Gly Asp Ser Ser Tyr Lys Leu Ile Phe
    450                 455                 460
Gly Ser Gly Thr Arg Leu Leu Val Arg Pro Asp Ile Gln Asn Pro Asp
465                 470                 475                 480
Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
                485                 490

<210> 52
<211> 813
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 2 alpha chain

<400> 52
atggagaccc tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa      60
caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctc     120
aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg     180
aaaggtctca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga     240
cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag     300
cctggtgact cagccaccta cctctgtgct gtgatcggcg aacagaattt tgtctttggt     360
cccggaacca gattgtccgt gctgccctat atccagaacc ctgaccctgc cgtgtaccag     420
ctgagagact ctaaatccag tgacaagtct gtctgcctat tcaccgattt tgattctcaa     480
acaaatgtgt cacaaagtaa ggattctgat gtgtatatca cagacaaaac tgtgctagac     540
atgaggtcta tggacttcaa gagcaacagt gctgtggcct ggagcaacaa atctgacttt     600
gcatgtgcaa acgccttcaa caacagcatt attccagaag acaccttctt ccccagccca     660
gaaagttcct gtgatgtcaa gctggtcgag aaaagctttg aaacagatac gaacctaaac     720
tttcaaaacc tgtcagtgat tgggttccga atcctcctcc tgaaagtggc cgggtttaat     780
ctgctcatga cgctgcggct gtggtccagc tga                                  813

<210> 53
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 alpha chain

<400> 53
Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp
 1               5                  10                  15
Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val
            20                  25                  30
Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala
        35                  40                  45
Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr
    50                  55                  60
Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg
65                  70                  75                  80
Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile
                85                  90                  95
Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Ile
            100                 105                 110
Gly Glu Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val Leu
        115                 120                 125
Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
    130                 135                 140
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
145                 150                 155                 160
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
                165                 170                 175
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
            180                 185                 190
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
        195                 200                 205
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
    210                 215                 220
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
225                 230                 235                 240
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
                245                 250                 255
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 54
<211> 948
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 2 beta chain

<400> 54
atgggcacca ggctcctctg ctgggcagcc ctgtgcctcc tgggggcaga tcacacaggt      60
gctggagtct cccagacccc cagtaacaag gtcacagaga agggaaaata tgtagagctc     120
aggtgtgatc caatttcagg tcatactgcc ctttactggt accgacaaag cctggggcag     180
ggcccagagt ttctaattta cttccaaggc acgggtgcgg cagatgactc agggctgccc     240
aacgatcggt tctttgcagt caggcctgag ggatccgtct ctactctgaa gatccagcgc     300
acagagcggg gggactcagc cgtgtatctc tgtgccagca gcttaagtgg gttaggctct     360
ggggccaacg tcctgacttt cggggccggc agcaggctga ccgtgctgga ggacctgaaa     420
aacgtgttcc cacccgaggt cgctgtgttt gagccatcag aagcagagat ctcccacacc     480
caaaaggcca cactggtgtg cctggccaca ggcttctacc ccgaccacgt ggagctgagc     540
tggtgggtga atgggaagga ggtgcacagt ggggtcagca cagacccgca gcccctcaag     600
gagcagcccg ccctcaatga ctccagatac tgcctgagca gccgcctgag ggtctcggcc     660
accttctggc agaacccccg caaccacttc cgctgtcaag tccagttcta cgggctctcg     720
gagaatgacg agtggaccca ggatagggcc aaacctgtca cccagatcgt cagcgccgag     780
gcctggggta gagcagactg tggcttcacc tccgagtctt accagcaagg ggtcctgtct     840
gccaccatcc tctatgagat cttgctaggg aaggccacct tgtatgccgt gctggtcagt     900
gccctcgtgc tgatggccat ggtcaagaga aaggattcca gaggctag                  948

<210> 55
<211> 315
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 beta chain

<400> 55
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr
            20                  25                  30
Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu
                85                  90                  95
Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Ser Gly Leu Gly Ser Gly Ala Asn Val Leu Thr Phe Gly
        115                 120                 125
Ala Gly Ser Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro
    130                 135                 140
Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr
145                 150                 155                 160
Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His
                165                 170                 175
Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val
            180                 185                 190
Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser
        195                 200                 205
Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln
    210                 215                 220
Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser
225                 230                 235                 240
Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile
                245                 250                 255
Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu
            260                 265                 270
Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu
        275                 280                 285
Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu
    290                 295                 300
Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310                 315

<210> 56
<211> 1496
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 2 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 56
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgggcacc agactgctgt      60
gttgggctgc tctgtgtctg ctgggagccg atcatacagg tgccggtgtc agccagacac     120
ctagcaacaa agtgaccgag aagggcaaat acgtggaact gagatgcgac cccatcagcg     180
gacacacagc cctgtactgg tacagacagt ctctcggcca gggacctgag ttcctgatct     240
acttccaagg caccggcgct gccgatgata gcggcctgcc taacgataga ttcttcgccg     300
tcagacccga gggcagcgtg tccacactga agatccagag aaccgagagg ggcgacagcg     360
ccgtgtatct gtgtgcctct tctctgtctg gcctcggctc tggcgctaac gtgctgacat     420
ttggcgccgg aagcagactg accgtgctgg aagatctgaa gaacgtgttc ccacctgagg     480
tggccgtgtt cgagccttct gaggccgaga tcagccacac acagaaagcc acactcgtgt     540
gtctggccac cggcttctat cccgaccatg tggaactgtc ttggtgggtc aacggcaaag     600
aggtgcacag cggcgtctgt acagatcccc agcctctgaa agaacagccc gctctgaacg     660
acagccggta ctgtctgtcc tccagactga gagtgtccgc caccttctgg cagaacccca     720
gaaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgat gagtggaccc     780
aggatagagc caagcctgtg acacagatcg tgtctgccga agcctggggc agagccgatt     840
gtggctttac cagcgagagc taccagcagg gcgtgctgtc tgccacaatc ctgtacgaga     900
tcctgctggg caaagccact ctgtacgccg tgctggtgtc tgccctggtg ctgatggcca     960
tggtcaagcg gaaggacagc agaggcggtt ccggagccac gaacttctct ctgttaaagc    1020
aagcaggaga cgtggaagaa aaccccggtc ccatggaaac actgctgggc ctgctgatcc    1080
tgtggctgca actgcaatgg gtgtccagca agcaagaagt gacacagatc cctgccgctc    1140
tgtctgtgcc tgagggcgaa aacctggtgc tgaactgcag cttcaccgac agcgccatct    1200
acaacctgca gtggttcaga caggaccccg gcaagggact gacaagcctg ctgctgattc    1260
agagcagcca gagagagcag accagcggca gactgaatgc cagcctggat aagtcctccg    1320
gcagaagcac cctgtatatc gccgcttctc agcctggcga tagcgccaca tatctgtgtg    1380
ccgtgatcgg cgagcagaac ttcgtgtttg gccctggcac aagactgagc gtgctgccct    1440
acattcagaa ccccgatcct gccgtgtacc agctgcggga cagcaagagc agcgac        1496

<210> 57
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 2 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 57
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Gly Thr Arg Leu
 1               5                  10                  15
Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Asp His Thr Gly Ala
            20                  25                  30
Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Tyr
        35                  40                  45
Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp
    50                  55                  60
Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr Phe Gln
65                  70                  75                  80
Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg Phe Phe
                85                  90                  95
Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln Arg Thr
            100                 105                 110
Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Ser Gly
        115                 120                 125
Leu Gly Ser Gly Ala Asn Val Leu Thr Phe Gly Ala Gly Ser Arg Leu
    130                 135                 140
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
145                 150                 155                 160
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
                165                 170                 175
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
            180                 185                 190
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
        195                 200                 205
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
    210                 215                 220
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
225                 230                 235                 240
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
                245                 250                 255
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
            260                 265                 270
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
        275                 280                 285
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
    290                 295                 300
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
305                 310                 315                 320
Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                325                 330                 335
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Leu
            340                 345                 350
Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp Val Ser Ser Lys
        355                 360                 365
Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly Glu
    370                 375                 380
Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn Leu
385                 390                 395                 400
Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu Leu
                405                 410                 415
Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala Ser
            420                 425                 430
Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln
        435                 440                 445
Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Ile Gly Glu Gln Asn
    450                 455                 460
Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val Leu Pro Tyr Ile Gln
465                 470                 475                 480
Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
                485                 490                 495

<210> 58
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 3 alpha chain

<400> 58
atgatgaaat ccttgagagt tttactagtg atcctgtggc ttcagttgag ctgggtttgg      60
agccaacaga aggaggtgga gcagaattct ggacccctca gtgttccaga gggagccatt     120
gcctctctca actgcactta cagtgaccga ggttcccagt ccttcttctg gtacagacaa     180
tattctggga aaagccctga gttgataatg tccatatact ccaatggtga caaagaagat     240
ggaaggttta cagcacagct caataaagcc agccagtatg tttctctgct catcagagac     300
tcccagccca gtgattcagc cacctacctc tgtgccgtcg attctggggg ttaccagaaa     360
gttacctttg gaactggaac aaagctccaa gtcatcccaa atatccagaa ccctgaccct     420
gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat     480
tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa     540
actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac     600
aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc     660
ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat     720
acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg     780
gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                     825

<210> 59
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 alpha chain

<400> 59
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu
 1               5                  10                  15
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro
            20                  25                  30
Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser
        35                  40                  45
Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys
    50                  55                  60
Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp
65                  70                  75                  80
Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu
                85                  90                  95
Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala
            100                 105                 110
Val Asp Ser Gly Gly Tyr Gln Lys Val Thr Phe Gly Thr Gly Thr Lys
        115                 120                 125
Leu Gln Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
    130                 135                 140
Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp
145                 150                 155                 160
Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr
                165                 170                 175
Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser
            180                 185                 190
Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn
        195                 200                 205
Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro
    210                 215                 220
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
225                 230                 235                 240
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu
                245                 250                 255
Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp
            260                 265                 270
Ser Ser


<210> 60
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 3 and TCR number 10 beta chain

<400> 60
atgggcacca ggctcctctg ctgggcagcc ctgtgcctcc tgggggcaga tcacacaggt      60
gctggagtct cccagacccc cagtaacaag gtcacagaga agggaaaata tgtagagctc     120
aggtgtgatc caatttcagg tcatactgcc ctttactggt accgacaaag cctggggcag     180
ggcccagagt ttctaattta cttccaaggc acgggtgcgg cagatgactc agggctgccc     240
aacgatcggt tctttgcagt caggcctgag ggatccgtct ctactctgaa gatccagcgc     300
acagagcggg gggactcagc cgtgtatctc tgtgccagca gcttaaatat gaacactgaa     360
gctttctttg gacaaggcac cagactcaca gttgtagagg acctgaacaa ggtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg     900
atggccatgg tcaagagaaa ggatttctga                                      930

<210> 61
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 and TCR number 10 beta chain

<400> 61
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr
            20                  25                  30
Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu
                85                  90                  95
Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Asn Met Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe
305

<210> 62
<211> 1490
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 3 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 62
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgggcacc agactgctgt      60
gttgggccgc tctgtgtctg ctgggcgccg atcatacagg cgctggcgtg tcccagaccc     120
ccagcaacaa agtgaccgag aagggcaaat acgtggaact gagatgcgac cccatcagcg     180
gccacaccgc cctgtactgg tacagacagt ctctgggcca gggccccgag ttcctgatat     240
attttcaggg caccggcgct gccgacgaca gcggcctgcc taacgataga ttcttcgccg     300
tgcggcccga gggcagcgtg tccacactga agatccagag aaccgagcgg ggcgacagcg     360
ccgtgtatct gtgtgccagc agcctgaata tgaacaccga ggcattcttt gggcagggca     420
cccggctgac cgtggtggaa gatctgaaca aggtgttccc cccagaggtg gccgtgttcg     480
agccttctga ggccgagatc agccacaccc agaaagccac cctcgtgtgc ctggccaccg     540
gctttttccc cgaccatgtg gaactgtctt ggtgggtcaa cggcaaagag gtgcacagcg     600
gagtgtccac cgaccctcag cccctgaaag aacagcccgc cctgaacgac agccggtact     660
gcctgagcag cagactgaga gtgtccgcca ccttctggca gaacccccgg aaccacttca     720
gatgccaggt gcagttctac ggcctgagcg agaacgacga gtggacccag gacagagcca     780
agcccgtgac ccagatcgtg tctgccgaag cctggggcag agccgattgc ggctttacct     840
ccgtgtccta tcagcagggc gtgctgagcg ccaccatcct gtacgagatc ctgctgggca     900
aggccaccct gtacgccgtg ctggtgtctg ccctggtgct gatggccatg gtcaagcgga     960
aggacttcgg ttccggagcc acgaacttct ctctgttaaa gcaagcagga gacgtggaag    1020
aaaaccccgg tcccatgatg aagtccctgc gggtgctgct cgtgatcctg tggctgcagc    1080
tgtcttgggt gtggtcccag cagaaagagg tggaacagaa cagcggccct ctgagcgtgc    1140
cagagggcgc cattgctagc ctgaattgca cctacagcga ccggggcagc cagagcttct    1200
tctggtatcg gcagtacagc ggcaagagcc ccgagctgat catgagcatc tacagcaacg    1260
gcgacaaaga ggacggccgg ttcaccgccc agctgaacaa agccagccag tacgtgtcac    1320
tgctgatccg ggacagccag cccagcgata gcgccacata cctgtgcgcc gtggatagcg    1380
gcggctacca gaaagtgacc ttcggcaccg gcaccaagct gcaagtgatc cccaacatcc    1440
agaaccccga ccccgctgtg taccagctgc gggacagcaa gagcagcgac               1490

<210> 63
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 3 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 63
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Gly Thr Arg Leu
 1               5                  10                  15
Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Asp His Thr Gly Ala
            20                  25                  30
Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Tyr
        35                  40                  45
Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp
    50                  55                  60
Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr Phe Gln
65                  70                  75                  80
Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg Phe Phe
                85                  90                  95
Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln Arg Thr
            100                 105                 110
Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Asn Met
        115                 120                 125
Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu
    130                 135                 140
Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
145                 150                 155                 160
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
                165                 170                 175
Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
            180                 185                 190
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu
        195                 200                 205
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
    210                 215                 220
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
225                 230                 235                 240
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
                245                 250                 255
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
            260                 265                 270
Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala
        275                 280                 285
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
    290                 295                 300
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe
305                 310                 315                 320
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
                325                 330                 335
Glu Glu Asn Pro Gly Pro Met Met Lys Ser Leu Arg Val Leu Leu Val
            340                 345                 350
Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser Gln Gln Lys Glu Val
        355                 360                 365
Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser
    370                 375                 380
Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr
385                 390                 395                 400
Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser
                405                 410                 415
Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala
            420                 425                 430
Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser
        435                 440                 445
Ala Thr Tyr Leu Cys Ala Val Asp Ser Gly Gly Tyr Gln Lys Val Thr
    450                 455                 460
Phe Gly Thr Gly Thr Lys Leu Gln Val Ile Pro Asn Ile Gln Asn Pro
465                 470                 475                 480
Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
                485                 490

<210> 64
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 10 alpha chain

<400> 64
atggaaactc tcctgggagt gtctttggtg attctatggc ttcaactggc tagggtgaac      60
agtcaacagg gagaagagga tcctcaggcc ttgagcatcc aggagggtga aaatgccacc     120
atgaactgca gttacaaaac tagtataaac aatttacagt ggtatagaca aaattcaggt     180
agaggccttg tccacctaat tttaatacgt tcaaatgaaa gagagaaaca cagtggaaga     240
ttaagagtca cgcttgacac ttccaagaaa agcagttcct tgttgatcac ggcttcccgg     300
gcagcagaca ctgcttctta cttctgtgct acggacgaga gtagcaacta taaactgaca     360
tttggaaaag gaactctctt aaccgtgaat ccaaatatcc agaaccctga ccctgccgtg     420
taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat     480
tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg     540
ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct     600
gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc     660
agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac     720
ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg     780
tttaatctgc tcatgacgct gcggctgtgg tccagctga                            819

<210> 65
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 alpha chain

<400> 65
Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu
 1               5                  10                  15
Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser
            20                  25                  30
Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser
        35                  40                  45
Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val
    50                  55                  60
His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg
65                  70                  75                  80
Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile
                85                  90                  95
Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp
            100                 105                 110
Glu Ser Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu Thr
        115                 120                 125
Val Asn Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
    130                 135                 140
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
145                 150                 155                 160
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                165                 170                 175
Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
            180                 185                 190
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
        195                 200                 205
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
    210                 215                 220
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
225                 230                 235                 240
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                245                 250                 255
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 66
<211> 1484
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 10 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 66
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgggcacc agactgctgt      60
gttgggccgc tctgtgtctg ctgggcgccg atcatacagg cgctggcgtg tcccagaccc     120
ccagcaacaa agtgaccgag aagggcaaat acgtggaact gagatgcgac cccatcagcg     180
gccacaccgc cctgtactgg tacagacagt ctctgggcca gggccccgag ttcctgatat     240
attttcaggg caccggcgct gccgacgaca gcggcctgcc taacgataga ttcttcgccg     300
tgcggcccga gggcagcgtg tccacactga agatccagag aaccgagcgg ggcgacagcg     360
ccgtgtatct gtgtgccagc agcctgaata tgaacaccga ggcattcttt gggcagggca     420
cccggctgac cgtggtggaa gatctgaaca aggtgttccc cccagaggtg gccgtgttcg     480
agccttctga ggccgagatc agccacaccc agaaagccac cctcgtgtgc ctggccaccg     540
gctttttccc cgaccatgtg gaactgtctt ggtgggtcaa cggcaaagag gtgcacagcg     600
gagtgtccac cgaccctcag cccctgaaag aacagcccgc cctgaacgac agccggtact     660
gcctgagcag cagactgaga gtgtccgcca ccttctggca gaacccccgg aaccacttca     720
gatgccaggt gcagttctac ggcctgagcg agaacgacga gtggacccag gacagagcca     780
agcccgtgac ccagatcgtg tctgccgaag cctggggcag agccgattgc ggctttacct     840
ccgtgtccta tcagcagggc gtgctgagcg ccaccatcct gtacgagatc ctgctgggca     900
aggccaccct gtacgccgtg ctggtgtctg ccctggtgct gatggccatg gtcaagcgga     960
aggacttcgg ttccggagcc acgaacttct ctctgttaaa gcaagcagga gacgtggaag    1020
aaaaccccgg tcccatggaa accctgctgg gagtgtccct cgtgatcctg tggctgcagc    1080
tggccagagt gaacagccag cagggggaag aggatcccca ggccctgagc attcaggaag    1140
gcgagaacgc caccatgaac tgcagctaca agaccagcat caacaacctg cagtggtaca    1200
ggcagaacag cggcagaggc ctggtgcacc tgatcctgat cagaagcaac gagagagaga    1260
agcactccgg acggctgaga gtgaccctgg acacctccaa gaagtcctcc agcctgctga    1320
tcaccgccag cagagccgcc gataccgcca gctacttctg cgccacagac gagagcagca    1380
actacaagct gaccttcggc aagggcacac tgctgacagt gaaccccaac atccagaacc    1440
ccgaccccgc tgtgtaccag ctgcgggaca gcaagagcag cgac                     1484

<210> 67
<211> 492
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 10 construct
      polypeptide; beta chain-P2A-alpha chain with
      cysteine substitutions in beta and alpha chain
      constant domains (partial sequence)

<400> 67
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Gly Thr Arg Leu
 1               5                  10                  15
Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Asp His Thr Gly Ala
            20                  25                  30
Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Tyr
        35                  40                  45
Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp
    50                  55                  60
Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr Phe Gln
65                  70                  75                  80
Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg Phe Phe
                85                  90                  95
Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln Arg Thr
            100                 105                 110
Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Asn Met
        115                 120                 125
Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu
    130                 135                 140
Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
145                 150                 155                 160
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
                165                 170                 175
Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
            180                 185                 190
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu
        195                 200                 205
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
    210                 215                 220
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
225                 230                 235                 240
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
                245                 250                 255
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
            260                 265                 270
Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala
        275                 280                 285
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
    290                 295                 300
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe
305                 310                 315                 320
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
                325                 330                 335
Glu Glu Asn Pro Gly Pro Met Glu Thr Leu Leu Gly Val Ser Leu Val
            340                 345                 350
Ile Leu Trp Leu Gln Leu Ala Arg Val Asn Ser Gln Gln Gly Glu Glu
        355                 360                 365
Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu Asn Ala Thr Met Asn
    370                 375                 380
Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn
385                 390                 395                 400
Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile Arg Ser Asn Glu Arg
                405                 410                 415
Glu Lys His Ser Gly Arg Leu Arg Val Thr Leu Asp Thr Ser Lys Lys
            420                 425                 430
Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser
        435                 440                 445
Tyr Phe Cys Ala Thr Asp Glu Ser Ser Asn Tyr Lys Leu Thr Phe Gly
    450                 455                 460
Lys Gly Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Asp Pro
465                 470                 475                 480
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
                485                 490

<210> 68
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 7 alpha chain

<400> 68
atggagaaga atcctttggc agccccatta ctaatcctct ggtttcatct tgactgcgtg      60
agcagcatac tgaacgtgga acaaagtcct cagtcactgc atgttcagga gggagacagc     120
accaatttca cctgcagctt cccttccagc aatttttatg ccttacactg gtacagatgg     180
gaaactgcaa aaagccccga ggccttgttt gtaatgactt taaatgggga tgaaaagaag     240
aaaggacgaa taagtgccac tcttaatacc aaggagggtt acagctattt gtacatcaaa     300
ggatcccagc ctgaagactc agccacatac ctctgtgcct atttaggggc cggtaaccag     360
ttctattttg ggacagggac aagtttgacg gtcattccaa atatccagaa ccctgaccct     420
gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat     480
tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa     540
actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac     600
aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc     660
ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat     720
acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg     780
gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                     825

<210> 69
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 alpha chain

<400> 69
Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His
 1               5                  10                  15
Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser
            20                  25                  30
Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro
        35                  40                  45
Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys
    50                  55                  60
Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys
65                  70                  75                  80
Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr
                85                  90                  95
Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys
            100                 105                 110
Ala Tyr Leu Gly Ala Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser
        115                 120                 125
Leu Thr Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
    130                 135                 140
Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp
145                 150                 155                 160
Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr
                165                 170                 175
Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser
            180                 185                 190
Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn
        195                 200                 205
Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro
    210                 215                 220
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
225                 230                 235                 240
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu
                245                 250                 255
Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp
            260                 265                 270
Ser Ser


<210> 70
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 7 beta chain

<400> 70
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat      60
ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg     120
agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa     180
gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct     240
gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc     300
caaaagaacc cgacagcttt ctatctctgt gccagtagcc tcaacagggg ccgctatggc     360
tacaccttcg gttcggggac caggttaacc gttgtagagg acctgaacaa ggtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg     900
atggccatgg tcaagagaaa ggatttctga                                      930

<210> 71
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 beta chain

<400> 71
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Asn Arg Gly Arg Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe
305

<210> 72
<211> 1490
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 7 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)
      

<400> 72
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgagcaac caggtcttgt      60
gctgtgtggt gctgtgcttt cttggcgcca atacagtgga tggcggcatt acacagagcc     120
ctaagtacct gttccggaaa gaaggccaga acgtgacact gtcttgcgag caaaacctga     180
accacgatgc catgtactgg tacagacagg atcctggaca gggacttagg ctgatctact     240
atagccagat cgtgaacgac ttccagaagg gcgatattgc cgagggctat tctgtgtctc     300
gggagaaaaa ggagagcttc cctctgacag tgacatctgc ccagaagaat cctaccgcct     360
tctacctttg tgccagctct ctgaatcggg gcagatacgg atacaccttt ggatctggca     420
ccagactgac agtggtggaa gatctgaaca aggtgttccc cccagaggtg gccgtgttcg     480
agccttctga ggccgagatc tcccacaccc agaaagccac cctcgtgtgc ctggccaccg     540
gctttttccc cgaccacgtg gaactgtctt ggtgggtcaa cggcaaagag gtgcactccg     600
gcgtgtgcac cgatccccag cctctgaaag aacagcccgc cctgaacgac agccggtact     660
gcctgagcag cagactgaga gtgtccgcca ccttctggca gaacccccgg aaccacttca     720
gatgccaggt gcagttctac ggcctgagcg agaacgacga gtggacccag gacagagcca     780
agcccgtgac acagatcgtg tctgccgaag cctggggcag agccgattgc ggctttacct     840
ccgtgtccta tcagcagggc gtgctgagcg ccacaatcct gtacgagatc ctgctgggca     900
aggccaccct gtacgccgtg ctggtgtctg ccctggtgct gatggccatg gtcaagcgga     960
aggacttcgg ttccggagcc acgaacttct ctctgttaaa gcaagcagga gacgtggaag    1020
aaaaccccgg tcccatggag aagaaccccc ttgcagcacc tctgcttatt ctgtggttcc    1080
acctggattg cgtgagctct atcctgaatg tggagcagtc tcctcagtct ctgcatgttc    1140
aggaaggcga tagcaccaac ttcacctgta gctttcccag cagcaacttc tatgccctgc    1200
actggtacag atgggaaaca gccaaaagcc ctgaagccct gttcgtgatg acccttaatg    1260
gcgatgagaa gaagaagggc cggatttctg ccaccctgaa tacaaaagag ggctacagct    1320
acctgtacat caagggatct cagcctgagg atagcgccac atatctgtgt gcctatctgg    1380
gagccggcaa tcagttctat ttcggaacag gcaccagcct gaccgtgatt cctaatatcc    1440
agaaccccga tcctgccgtg taccagctgc gggacagcaa gagcagcgac               1490

<210> 73
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 7 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 73
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Ser Asn Gln Val
 1               5                  10                  15
Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala Asn Thr Val Asp Gly
            20                  25                  30
Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn
        35                  40                  45
Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp
    50                  55                  60
Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln
65                  70                  75                  80
Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val
                85                  90                  95
Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln
            100                 105                 110
Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Leu Asn Arg Gly
        115                 120                 125
Arg Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val Glu
    130                 135                 140
Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
145                 150                 155                 160
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
                165                 170                 175
Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
            180                 185                 190
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
        195                 200                 205
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
    210                 215                 220
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
225                 230                 235                 240
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
                245                 250                 255
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
            260                 265                 270
Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala
        275                 280                 285
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
    290                 295                 300
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe
305                 310                 315                 320
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
                325                 330                 335
Glu Glu Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu
            340                 345                 350
Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val
        355                 360                 365
Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn
    370                 375                 380
Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr
385                 390                 395                 400
Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu
                405                 410                 415
Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr
            420                 425                 430
Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp
        435                 440                 445
Ser Ala Thr Tyr Leu Cys Ala Tyr Leu Gly Ala Gly Asn Gln Phe Tyr
    450                 455                 460
Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro Asn Ile Gln Asn Pro
465                 470                 475                 480
Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
                485                 490

<210> 74
<211> 837
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 8 alpha chain

<400> 74
atgctgactg ccagcctgtt gagggcagtc atagcctcca tctgtgttgt atccagcatg      60
gctcagaagg taactcaagc gcagactgaa atttctgtgg tggagaagga ggatgtgacc     120
ttggactgtg tgtatgaaac ccgtgatact acttattact tattctggta caagcaacca     180
ccaagtggag aattggtttt ccttattcgt cggaactctt ttgatgagca aaatgaaata     240
agtggtcggt attcttggaa cttccagaaa tccaccagtt ccttcaactt caccatcaca     300
gcctcacaag tcgtggactc agcagtatac ttctgtgctc tgagtgagct agcatcagga     360
ggaagctaca tacctacatt tggaagagga accagcctta ttgttcatcc gtatatccag     420
aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa gtctgtctgc     480
ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat     540
atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg     600
gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca     660
gaagacacct tcttccccag cccagaaagt tcctgtgatg tcaagctggt cgagaaaagc     720
tttgaaacag atacgaacct aaactttcaa aacctgtcag tgattgggtt ccgaatcctc     780
ctcctgaaag tggccgggtt taatctgctc atgacgctgc ggctgtggtc cagctga        837

<210> 75
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 alpha chain

<400> 75
Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val
 1               5                  10                  15
Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser
            20                  25                  30
Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg
        35                  40                  45
Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu
    50                  55                  60
Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile
65                  70                  75                  80
Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn
                85                  90                  95
Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys
            100                 105                 110
Ala Leu Ser Glu Leu Ala Ser Gly Gly Ser Tyr Ile Pro Thr Phe Gly
        115                 120                 125
Arg Gly Thr Ser Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro
    130                 135                 140
Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys
145                 150                 155                 160
Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
                165                 170                 175
Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met
            180                 185                 190
Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe
        195                 200                 205
Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe
    210                 215                 220
Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser
225                 230                 235                 240
Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly
                245                 250                 255
Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr
            260                 265                 270
Leu Arg Leu Trp Ser Ser
        275

<210> 76
<211> 948
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 8 beta chain

<400> 76
atgggccccg ggctcctctg ctgggcactg ctttgtctcc tgggagcagg cttagtggac      60
gctggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg     120
agatgctctc ctaagtctgg gcatgacact gtgtcctggt accaacaggc cctgggtcag     180
gggccccagt ttatctttca gtattatgag gaggaagaga gacagagagg caacttccct     240
gatcgattct caggtcacca gttccctaac tatagctctg agctgaatgt gaacgccttg     300
ttgctggggg actcggccct ctatctctgt gccagcagct ttaggctagc gggggggcct     360
agcacagata cgcagtattt tggcccaggc acccggctga cagtgctcga ggacctgaaa     420
aacgtgttcc cacccgaggt cgctgtgttt gagccatcag aagcagagat ctcccacacc     480
caaaaggcca cactggtgtg cctggccaca ggcttctacc ccgaccacgt ggagctgagc     540
tggtgggtga atgggaagga ggtgcacagt ggggtcagca cagacccgca gcccctcaag     600
gagcagcccg ccctcaatga ctccagatac tgcctgagca gccgcctgag ggtctcggcc     660
accttctggc agaacccccg caaccacttc cgctgtcaag tccagttcta cgggctctcg     720
gagaatgacg agtggaccca ggatagggcc aaacctgtca cccagatcgt cagcgccgag     780
gcctggggta gagcagactg tggcttcacc tccgagtctt accagcaagg ggtcctgtct     840
gccaccatcc tctatgagat cttgctaggg aaggccacct tgtatgccgt gctggtcagt     900
gccctcgtgc tgatggccat ggtcaagaga aaggattcca gaggctag                  948

<210> 77
<211> 315
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 beta chain

<400> 77
Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His
        35                  40                  45
Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro
65                  70                  75                  80
Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Phe Arg Leu Ala Gly Gly Pro Ser Thr Asp Thr Gln Tyr Phe Gly
        115                 120                 125
Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro
    130                 135                 140
Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr
145                 150                 155                 160
Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His
                165                 170                 175
Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val
            180                 185                 190
Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser
        195                 200                 205
Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln
    210                 215                 220
Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser
225                 230                 235                 240
Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile
                245                 250                 255
Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu
            260                 265                 270
Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu
        275                 280                 285
Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu
    290                 295                 300
Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310                 315

<210> 78
<211> 1520
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 8 construct;  beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 78
ctcaataaaa gagcccacaa cccctcactc ggcgcgccac catgggacct ggactgcttt      60
gttgggctct tctgtgtctg cttggagctg gactggttga tgctggagtt acacagagcc     120
ctacacacct gatcaagaca agaggacagc aggtgaccct gagatgtagc cctaaatctg     180
gccacgatac cgtgagctgg tatcaacagg ctctgggaca aggacctcag ttcatcttcc     240
agtactacga ggaggaggag agacagagag gcaatttccc tgacaggttt agcggacacc     300
agttccccaa ttacagctct gagctgaacg tgaatgccct tcttctggga gattctgccc     360
tgtatctgtg tgccagcagc tttagactgg ctggaggacc tagcaccgat acacagtatt     420
ttggacctgg caccaggctg acagtgttag aagacctgaa gaacgtgttc cccccagagg     480
tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc accctcgtgt     540
gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc aacggcaaag     600
aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc gccctgaacg     660
acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg cagaaccccc     720
ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac gagtggaccc     780
aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc agagccgatt     840
gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc ctgtacgaga     900
tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg ctgatggcca     960
tggtcaagcg gaaggacagc cggggcggtt ccggagccac gaacttctct ctgttaaagc    1020
aagcaggaga cgtggaagaa aaccccggtc ccatgttgac cgcttctctc ttacgtgccg    1080
tgattgccag catctgtgtg gttagctcta tggcccagaa ggtgacacaa gctcagacag    1140
agatcagcgt ggtggagaaa gaggatgtga ccctggattg cgtgtacgag accagagata    1200
ccacctacta cctgttctgg tacaagcagc ctccttctgg agaactggtg ttcctgatca    1260
gacggaacag cttcgatgag cagaacgaga ttagcggcag gtatagctgg aacttccaga    1320
agagcaccag cagcttcaac ttcaccatca cagcctctca ggtggtggat tctgccgtgt    1380
acttttgtgc cctgtctgaa ctggcctctg gaggaagcta tatccctaca ttcggcagag    1440
gcacaagcct gattgtgcac ccttacatcc agaaccctga tcctgctgtg taccagctgc    1500
gggacagcaa gagcagcgac                                                1520

<210> 79
<211> 504
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 8 construct
      polypeptide;  beta chain-P2A-alpha chain with
      cysteine substitutions in beta and alpha chain
      constant domains (partial sequence)

<400> 79
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Gly Pro Gly Leu
 1               5                  10                  15
Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala Gly Leu Val Asp Ala
            20                  25                  30
Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln
        35                  40                  45
Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His Asp Thr Val Ser Trp
    50                  55                  60
Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr
65                  70                  75                  80
Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro Asp Arg Phe Ser Gly
                85                  90                  95
His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Leu
            100                 105                 110
Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Phe Arg Leu Ala
        115                 120                 125
Gly Gly Pro Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
    130                 135                 140
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
145                 150                 155                 160
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
                165                 170                 175
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
            180                 185                 190
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
        195                 200                 205
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
    210                 215                 220
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
225                 230                 235                 240
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
                245                 250                 255
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
            260                 265                 270
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
        275                 280                 285
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
    290                 295                 300
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
305                 310                 315                 320
Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                325                 330                 335
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Thr Ala
            340                 345                 350
Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val Val Ser Ser Met
        355                 360                 365
Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser Val Val Glu Lys
    370                 375                 380
Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg Asp Thr Thr Tyr
385                 390                 395                 400
Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu Leu Val Phe Leu
                405                 410                 415
Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile Ser Gly Arg Tyr
            420                 425                 430
Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn Phe Thr Ile Thr
        435                 440                 445
Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser Glu
    450                 455                 460
Leu Ala Ser Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser
465                 470                 475                 480
Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
                485                 490                 495
Leu Arg Asp Ser Lys Ser Ser Asp
            500

<210> 80
<211> 1836
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 4 construct; beta chain-P2A-alpha chain

<400> 80
accatgggca ccaggctcct cttctgggtg gccttctgtc tcctgggggc agatcacaca      60
ggagctggag tctcccagtc ccccagtaac aaggtcacag agaagggaaa ggatgtagag     120
ctcaggtgtg atccaatttc aggtcatact gccctttact ggtaccgaca gagcctgggg     180
cagggcctgg agtttttaat ttacttccaa ggcaacagtg caccagacaa atcagggctg     240
cccagtgatc gcttctctgc agagaggact gggggatccg tctccactct gacgatccag     300
cgcacacagc aggaggactc ggccgtgtat ctctgtgcca gcagcttagt ggtcggctcc     360
tacgagcagt acttcgggcc gggcaccagg ctcacggtca cagaggacct gaaaaacgtg     420
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     480
gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg     540
gtgaatggga aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag     600
cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     660
tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     720
gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg     780
ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc     840
atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc     900
gtgctgatgg ccatggtcaa gagaaaggat tccagaggcg gttccggagc cacgaacttc     960
tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatgga aactctcctg    1020
ggagtgtctt tggtgattct atggcttcaa ctggctaggg tgaacagtca acagggagaa    1080
gaggatcctc aggccttgag catccaggag ggtgaaaatg ccaccatgaa ctgcagttac    1140
aaaactagta taaacaattt acagtggtat agacaaaatt caggtagagg ccttgtccac    1200
ctaattttaa tacgttcaaa tgaaagagag aaacacagtg gaagattaag agtcacgctt    1260
gacacttcca agaaaagcag ttccttgttg atcacggctt cccgggcagc agacactgct    1320
tcttacttct gtgctacgga cgcgtgggaa tctaactttg gaaatgagaa attaaccttt    1380
gggactggaa caagactcac catcataccc aatatccaga accctgaccc tgccgtgtac    1440
cagctgagag actctaaatc cagtgacaag tctgtctgcc tattcaccga ttttgattct    1500
caaacaaatg tgtcacaaag taaggattct gatgtgtata tcacagacaa aactgtgcta    1560
gacatgaggt ctatggactt caagagcaac agtgctgtgg cctggagcaa caaatctgac    1620
tttgcatgtg caaacgcctt caacaacagc attattccag aagacacctt cttccccagc    1680
ccagaaagtt cctgtgatgt caagctggtc gagaaaagct ttgaaacaga tacgaaccta    1740
aactttcaaa acctgtcagt gattgggttc cgaatcctcc tcctgaaagt ggccgggttt    1800
aatctgctca tgacgctgcg gctgtggtcc agctga                              1836

<210> 81
<211> 611
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 construct; beta chain-P2A-alpha chain

<400> 81
Thr Met Gly Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly
 1               5                  10                  15
Ala Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val
            20                  25                  30
Thr Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly
        35                  40                  45
His Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu
    50                  55                  60
Phe Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu
65                  70                  75                  80
Pro Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr
                85                  90                  95
Leu Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys
            100                 105                 110
Ala Ser Ser Leu Val Val Gly Ser Tyr Glu Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe
305                 310                 315                 320
Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met
                325                 330                 335
Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu Ala
            340                 345                 350
Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile
        355                 360                 365
Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile
    370                 375                 380
Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His
385                 390                 395                 400
Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu
                405                 410                 415
Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr
            420                 425                 430
Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Ala
        435                 440                 445
Trp Glu Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr
    450                 455                 460
Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
465                 470                 475                 480
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
                485                 490                 495
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
            500                 505                 510
Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys
        515                 520                 525
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
    530                 535                 540
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
545                 550                 555                 560
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
                565                 570                 575
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
            580                 585                 590
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
        595                 600                 605
Trp Ser Ser
    610

<210> 82
<211> 1837
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 4 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 82
caccatgggc accagactgc tgttctgggt ggccttctgt ctgctgggcg ccgatcatac      60
aggcgctggc gtgtcccaga gccccagcaa caaagtgacc gagaagggca aggacgtgga     120
actgagatgc gaccccatca gcggccacac cgccctgtac tggtacagac agtctctggg     180
ccagggcctg gaattcctga tatattttca gggcaacagc gcccctgaca agagcggcct     240
gccctccgat agattcagcg ccgagagaac aggcggcagc gtgtccaccc tgaccatcca     300
gagaacccag caggaagata gcgccgtgta cctgtgcgcc agcagcctgg tcgtgggcag     360
ctacgagcag tactttggcc caggcacccg gctgaccgtg accgaggatc tgaagaacgt     420
gttcccccca gaggtggccg tgttcgagcc ttctgaggcc gagatcagcc acacccagaa     480
agccaccctc gtgtgtctgg ccaccggctt ctaccccgac catgtggaac tgtcttggtg     540
ggtcaacggc aaagaggtgc actccggcgt gtgcaccgat ccccagcctc tgaaagaaca     600
gcccgccctg aacgacagcc ggtactgcct gagcagcaga ctgagagtgt ccgccacctt     660
ctggcagaac ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa     720
cgacgagtgg acccaggaca gagccaagcc cgtgacccag atcgtgtctg ccgaagcctg     780
gggcagagcc gattgcggct ttaccagcga gagctaccag cagggcgtgc tgagcgccac     840
catcctgtac gagattctgc tgggaaaggc cacactgtac gccgtgctgg tgtctgccct     900
ggtgctgatg gccatggtca agcggaagga cagcagaggc ggttccggag ccacgaactt     960
ctctctgtta aagcaagcag gagacgtgga agaaaacccc ggtcccatgg aaaccctgct    1020
gggagtgtcc ctcgtgatcc tgtggctgca gctggccaga gtgaacagcc agcaggggga    1080
agaggatcca caggccctga gcattcagga aggcgagaac gccaccatga actgcagcta    1140
caagaccagc atcaacaacc tgcagtggta caggcagaac tccggcagag gcctggtgca    1200
cctgatcctg atcagaagca acgagagaga gaagcacagc ggacggctga gagtgaccct    1260
ggacacctcc aagaagtcca gctccctgct gatcaccgcc agcagagccg ccgataccgc    1320
cagctacttc tgtgccacag acgcctggga gagcaacttc ggcaacgaga agctgacctt    1380
cggcaccggc acaagactga ccatcatccc caacatccag aaccccgacc ccgccgtgta    1440
tcagctgaga gacagcaaga gcagcgacaa gtccgtgtgc ctgttcaccg acttcgacag    1500
ccagaccaat gtgtcccagt ccaaggacag cgacgtgtac atcaccgata agtgcgtgct    1560
ggacatgcgc agcatggact tcaagagcaa ctccgccgtg gcctggtcca acaagagcga    1620
tttcgcctgc gccaacgcct tcaacaacag cattatcccc gaggacacat tcttcccaag    1680
ccccgagagc agctgcgacg tgaagctggt ggaaaagagc ttcgagacag acaccaacct    1740
gaacttccag aacctgagcg tgatcggctt ccggatcctg ctgctgaagg tggccggctt    1800
caacctgctg atgaccctga gactgtggtc cagctga                             1837

<210> 83
<211> 611
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 4 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 83
Thr Met Gly Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly
 1               5                  10                  15
Ala Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val
            20                  25                  30
Thr Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly
        35                  40                  45
His Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu
    50                  55                  60
Phe Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu
65                  70                  75                  80
Pro Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr
                85                  90                  95
Leu Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys
            100                 105                 110
Ala Ser Ser Leu Val Val Gly Ser Tyr Glu Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe
305                 310                 315                 320
Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met
                325                 330                 335
Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu Ala
            340                 345                 350
Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile
        355                 360                 365
Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile
    370                 375                 380
Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His
385                 390                 395                 400
Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu
                405                 410                 415
Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr
            420                 425                 430
Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Ala
        435                 440                 445
Trp Glu Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr
    450                 455                 460
Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
465                 470                 475                 480
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
                485                 490                 495
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
            500                 505                 510
Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys
        515                 520                 525
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
    530                 535                 540
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
545                 550                 555                 560
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
                565                 570                 575
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
            580                 585                 590
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
        595                 600                 605
Trp Ser Ser
    610

<210> 84
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta2 constant domain

<400> 84
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly


<210> 85
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> truncated EGFR polypeptide lacking signal peptide

<400> 85
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu
 1               5                  10                  15
Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile
            20                  25                  30
Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe
        35                  40                  45
Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr
    50                  55                  60
Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn
65                  70                  75                  80
Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg
                85                  90                  95
Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile
            100                 105                 110
Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val
        115                 120                 125
Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp
    130                 135                 140
Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn
145                 150                 155                 160
Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu
                165                 170                 175
Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser
            180                 185                 190
Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu
        195                 200                 205
Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln
    210                 215                 220
Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly
225                 230                 235                 240
Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro
                245                 250                 255
His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr
            260                 265                 270
Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His
        275                 280                 285
Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro
    290                 295                 300
Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala
305                 310                 315                 320
Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met
                325                 330                 335

<210> 86
<211> 497
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 6 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains (partial
      sequence)

<400> 86
Lys Ser Pro Gln Pro Leu Thr Arg Arg Ala Thr Met Ser Ile Ser Leu
 1               5                  10                  15
Leu Cys Cys Ala Ala Phe Pro Leu Leu Trp Ala Gly Pro Val Asn Ala
            20                  25                  30
Gly Val Thr Gln Thr Pro Lys Phe Arg Ile Leu Lys Ile Gly Gln Ser
        35                  40                  45
Met Thr Leu Gln Cys Thr Gln Asp Met Asn His Asn Tyr Met Tyr Trp
    50                  55                  60
Tyr Arg Gln Asp Pro Gly Met Gly Leu Lys Leu Ile Tyr Tyr Ser Val
65                  70                  75                  80
Gly Ala Gly Ile Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr Asn Val
                85                  90                  95
Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Glu Leu Ala Ala
            100                 105                 110
Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Asp Arg Ser Asn
        115                 120                 125
Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr Val Leu Glu
    130                 135                 140
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
145                 150                 155                 160
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
                165                 170                 175
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
            180                 185                 190
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu
        195                 200                 205
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
    210                 215                 220
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
225                 230                 235                 240
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
                245                 250                 255
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
            260                 265                 270
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
        275                 280                 285
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
    290                 295                 300
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
305                 310                 315                 320
Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly
                325                 330                 335
Asp Val Glu Glu Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala
            340                 345                 350
Pro Leu Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu
        355                 360                 365
Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser
    370                 375                 380
Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His
385                 390                 395                 400
Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met
                405                 410                 415
Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu
            420                 425                 430
Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro
        435                 440                 445
Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Gly Pro Tyr Asn Asp Tyr
    450                 455                 460
Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala Asn Ile
465                 470                 475                 480
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
                485                 490                 495
Asp


<210> 87
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Valpha CDR1

<400> 87
Lys Ala Leu Tyr Ser
 1               5

<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Valpha CDR2

<400> 88
Leu Leu Lys Gly Gly Glu Gln
 1               5

<210> 89
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Valpha CDR3

<400> 89
Gly Thr Glu Glu Ala Asn Asp Tyr Lys Leu Ser
 1               5                  10

<210> 90
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Valpha variable region

<400> 90
Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile Leu Arg Glu Gly Glu
 1               5                  10                  15
Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala Leu Tyr Ser Val His
            20                  25                  30
Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val Phe Leu Met Ile Leu
        35                  40                  45
Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys Ile Ser Ala Ser Phe
    50                  55                  60
Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu Thr Ala Ser Gln Leu
65                  70                  75                  80
Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Glu Glu Ala Asn Asp Tyr
                85                  90                  95
Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg
            100                 105

<210> 91
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Vbeta CDR1

<400> 91
Ser Gly Asp Leu Ser
 1               5

<210> 92
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Vbeta CDR2

<400> 92
Tyr Tyr Asn Gly Glu Glu
 1               5

<210> 93
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Vbeta CDR3

<400> 93
Ala Ser Ser Val Gly Gln Gly Ser Ser Tyr
 1               5                  10

<210> 94
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 5 Vbeta variable region

<400> 94
Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr Ala Thr Gly
 1               5                  10                  15
Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp Leu Ser Val
            20                  25                  30
Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile Gln
        35                  40                  45
Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu Glu Arg Phe
    50                  55                  60
Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn Leu Ser Ser
65                  70                  75                  80
Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Val Gly
                85                  90                  95
Gln Gly Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr
            100                 105                 110
Val Thr


<210> 95
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 and TCR number 11 Valpha CDR1

<400> 95
Val Ser Pro Phe Ser Asn
 1               5

<210> 96
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 and TCR number 11 Valpha CDR2

<400> 96
Thr Phe Ser Glu Asn Thr
 1               5

<210> 97
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 and TCR number 11 Valpha CDR3

<400> 97
Val Val Trp Gly Gly Asp Thr Asp Lys Leu Ile
 1               5                  10

<210> 98
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 and TCR number 11 Valpha variable
      region

<400> 98
Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly
 1               5                  10                  15
Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn
            20                  25                  30
Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr
        35                  40                  45
Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala
    50                  55                  60
Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser
65                  70                  75                  80
Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Trp Gly Gly Asp
                85                  90                  95
Thr Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe
            100                 105                 110

<210> 99
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 11 Vbeta CDR1

<400> 99
Trp Ser His Ser Tyr
 1               5

<210> 100
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 11 Vbeta CDR2

<400> 100
Ser Ala Ala Ala Asp Ile
 1               5

<210> 101
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 11 Vbeta CDR3

<400> 101
Ala Ser Ser Asp Gly Gly Gly Gln Tyr
 1               5

<210> 102
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 11 Vbeta variable region

<400> 102
Asp Ala Gly Ile Thr Gln Ser Pro Arg Tyr Lys Ile Thr Glu Thr Gly
 1               5                  10                  15
Arg Gln Val Thr Leu Met Cys His Gln Thr Trp Ser His Ser Tyr Met
            20                  25                  30
Phe Trp Tyr Arg Gln Asp Leu Gly His Gly Leu Arg Leu Ile Tyr Tyr
        35                  40                  45
Ser Ala Ala Ala Asp Ile Thr Asp Lys Gly Glu Val Pro Asp Gly Tyr
    50                  55                  60
Val Val Ser Arg Ser Lys Thr Glu Asn Phe Pro Leu Thr Leu Glu Ser
65                  70                  75                  80
Ala Thr Arg Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Asp Gly
                85                  90                  95
Gly Gly Gln Tyr Phe Pro Gly Thr Arg Leu Thr Val Thr
            100                 105

<210> 103
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 and TCR number 7  Valpha CDR1

<400> 103
Ser Ser Asn Phe Tyr Ala
 1               5

<210> 104
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Valpha CDR2

<400> 104
Met Thr Leu Asn Gly Asp Glu
 1               5

<210> 105
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Valpha CDR3

<400> 105
Cys Ala Leu Gly Pro Tyr Asn Asp Tyr Lys Leu Ser Phe
 1               5                  10

<210> 106
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Valpha variant region

<400> 106
Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly
 1               5                  10                  15
Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala
            20                  25                  30
Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe
        35                  40                  45
Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala
    50                  55                  60
Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser
65                  70                  75                  80
Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Gly Pro Tyr Asn
                85                  90                  95
Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala
            100                 105                 110

<210> 107
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Vbeta CDR1

<400> 107
Met Asn His Asn Tyr
 1               5

<210> 108
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Vbeta CDR2

<400> 108
Ser Val Gly Ala Gly Ile
 1               5

<210> 109
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Vbeta CDR3

<400> 109
Ala Ser Ser Asp Arg Ser Asn Thr Gly Glu Leu Phe
 1               5                  10

<210> 110
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 6 Vbeta variable region

<400> 110
Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Ile Leu Lys Ile Gly
 1               5                  10                  15
Gln Ser Met Thr Leu Gln Cys Thr Gln Asp Met Asn His Asn Tyr Met
            20                  25                  30
Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Lys Leu Ile Tyr Tyr
        35                  40                  45
Ser Val Gly Ala Gly Ile Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr
    50                  55                  60
Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Glu Leu
65                  70                  75                  80
Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Asp Arg
                85                  90                  95
Ser Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr Val
            100                 105                 110
Leu


<210> 111
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 and TCR number 2 Valpha CDR1

<400> 111
Asp Ser Ala Ile Tyr Asn
 1               5

<210> 112
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 and TCR number 2 Valpha CDR2

<400> 112
Ile Gln Ser Ser Gln Arg Glu
 1               5

<210> 113
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 Valpha CDR3

<400> 113
Ala Val Glu Gly Asp Ser Ser Tyr Lys Leu Ile
 1               5                  10

<210> 114
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 Valpha variable region

<400> 114
Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly
 1               5                  10                  15
Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn
            20                  25                  30
Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu
        35                  40                  45
Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala
    50                  55                  60
Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser
65                  70                  75                  80
Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Glu Gly Asp Ser
                85                  90                  95
Ser Tyr Lys Leu Ile Phe Gly Ser Gly Thr Arg Leu Leu Val Arg Pro
            100                 105                 110

<210> 115
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 and TCR number 8 Vbeta CDR1

<400> 115
Ser Gly His Asp Thr
 1               5

<210> 116
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 and TCR number 8 Vbeta CDR2

<400> 116
Tyr Tyr Glu Glu Glu Glu
 1               5

<210> 117
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 Vbeta CDR3

<400> 117
Ala Ser Ser Phe Phe Ser Gln Glu Thr Gln Tyr
 1               5                  10

<210> 118
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 1 Vbeta variable region

<400> 118
Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly
 1               5                  10                  15
Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His Asp Thr Val
            20                  25                  30
Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln
        35                  40                  45
Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro Asp Arg Phe
    50                  55                  60
Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala
65                  70                  75                  80
Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Phe Phe
                85                  90                  95
Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu
            100                 105                 110

<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 Valpha CDR3

<400> 119
Ala Val Ile Gly Glu Gln Asn Phe Val
 1               5

<210> 120
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 Valpha variable region

<400> 120
Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly
 1               5                  10                  15
Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn
            20                  25                  30
Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu
        35                  40                  45
Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala
    50                  55                  60
Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser
65                  70                  75                  80
Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Ile Gly Glu Gln
                85                  90                  95
Asn Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val Leu Pro
            100                 105                 110

<210> 121
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2, TCR number 3, and TCR number 10
      Vbeta CDR1

<400> 121
Ser Gly His Thr Ala
 1               5

<210> 122
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2, TCR number 3, and TCR number 10
      Vbeta CDR2

<400> 122
Phe Gln Gly Thr Gly Ala
 1               5

<210> 123
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 Vbeta CDR3

<400> 123
Ala Ser Ser Leu Ser Gly Leu Gly Ser Gly Ala Asn Val Leu Thr
 1               5                  10                  15

<210> 124
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 2 Vbeta variable region

<400> 124
Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly
 1               5                  10                  15
Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu
            20                  25                  30
Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr
        35                  40                  45
Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg
    50                  55                  60
Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln
65                  70                  75                  80
Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu
                85                  90                  95
Ser Gly Leu Gly Ser Gly Ala Asn Val Leu Thr Phe Gly Ala Gly Ser
            100                 105                 110
Arg Leu Thr Val Leu
        115

<210> 125
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Valpha CDR1

<400> 125
Asp Arg Gly Ser Gln Ser
 1               5

<210> 126
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Valpha CDR2

<400> 126
Ile Tyr Ser Asn Gly Asp
 1               5

<210> 127
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Valpha CDR3

<400> 127
Ala Val Asp Ser Gly Gly Tyr Gln Lys Val Thr
 1               5                  10

<210> 128
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Valpha variable region

<400> 128
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
 1               5                  10                  15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser
            20                  25                  30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
        35                  40                  45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
    50                  55                  60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65                  70                  75                  80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asp Ser Gly Gly Tyr
                85                  90                  95
Gln Lys Val Thr Phe Gly Thr Gly Thr Lys Leu Gln Val Ile
            100                 105                 110

<210> 129
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Vbeta CDR3

<400> 129
Ala Ser Ser Leu Asn Met Asn Thr Glu Ala Phe
 1               5                  10

<210> 130
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 3 Vbeta variable region

<400> 130
Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly
 1               5                  10                  15
Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu
            20                  25                  30
Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr
        35                  40                  45
Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg
    50                  55                  60
Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln
65                  70                  75                  80
Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu
                85                  90                  95
Asn Met Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val
            100                 105                 110
Val


<210> 131
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 and TCR number 4 Valpha CDR1

<400> 131
Thr Ser Ile Asn Asn
 1               5

<210> 132
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 and TCR number 4 Valpha CDR2

<400> 132
Ile Arg Ser Asn Glu Arg Glu
 1               5

<210> 133
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 Valpha CDR3

<400> 133
Ala Thr Asp Glu Ser Ser Asn Tyr Lys Leu Thr
 1               5                  10

<210> 134
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 Valpha variable region

<400> 134
Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly
 1               5                  10                  15
Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu
            20                  25                  30
Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu
        35                  40                  45
Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr
    50                  55                  60
Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg
65                  70                  75                  80
Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Glu Ser Ser Asn
                85                  90                  95
Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu Thr Val Asn
            100                 105                 110

<210> 135
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta2 constant domain, cysteine modified

<400> 135
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly


<210> 136
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 10 Vbeta variable region

<400> 136
Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr Glu Lys Gly
 1               5                  10                  15
Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu
            20                  25                  30
Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr
        35                  40                  45
Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg
    50                  55                  60
Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu Lys Ile Gln
65                  70                  75                  80
Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu
                85                  90                  95
Asn Met Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val
            100                 105                 110
Val


<210> 137
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 Valpha CDR3

<400> 137
Ala Thr Asp Ala Trp Glu Ser Asn Phe Gly Asn Glu Lys Leu Thr
 1               5                  10                  15

<210> 138
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 Valpha variable region

<400> 138
Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly
 1               5                  10                  15
Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu
            20                  25                  30
Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu
        35                  40                  45
Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr
    50                  55                  60
Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg
65                  70                  75                  80
Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Ala Trp Glu Ser
                85                  90                  95
Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr
            100                 105                 110
Ile Ile


<210> 139
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 Vbeta CDR2

<400> 139
Phe Gln Gly Asn Ser Ala
 1               5

<210> 140
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 Vbeta CDR3

<400> 140
Ala Ser Ser Leu Val Val Gly Ser Tyr Glu Gln Tyr
 1               5                  10

<210> 141
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 4 Vbeta variable region

<400> 141
Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly
 1               5                  10                  15
Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu
            20                  25                  30
Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr
        35                  40                  45
Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg
    50                  55                  60
Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln
65                  70                  75                  80
Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu
                85                  90                  95
Val Val Gly Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr
            100                 105                 110
Val Thr


<210> 142
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Valpha CDR2

<400> 142
Met Thr Leu Asn Gly Asp Glu
 1               5

<210> 143
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Valpha CDR3

<400> 143
Ala Tyr Leu Gly Ala Gly Asn Gln Phe Tyr
 1               5                  10

<210> 144
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Valpha variable region

<400> 144
Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly
 1               5                  10                  15
Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala
            20                  25                  30
Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe
        35                  40                  45
Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala
    50                  55                  60
Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser
65                  70                  75                  80
Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Tyr Leu Gly Ala Gly
                85                  90                  95
Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile
            100                 105                 110

<210> 145
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Vbeta CDR1

<400> 145
Leu Asn His Asp Ala
 1               5

<210> 146
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Vbeta CDR2

<400> 146
Ser Gln Ile Val Asn Asp
 1               5

<210> 147
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Vbeta CDR3

<400> 147
Ala Ser Ser Leu Asn Arg Gly Arg Tyr Gly Tyr Thr
 1               5                  10

<210> 148
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 7 Vbeta variable region

<400> 148
Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly
 1               5                  10                  15
Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met
            20                  25                  30
Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr
        35                  40                  45
Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr
    50                  55                  60
Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser
65                  70                  75                  80
Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Leu Asn
                85                  90                  95
Arg Gly Arg Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val
            100                 105                 110
Val


<210> 149
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Valpha CDR1

<400> 149
Thr Arg Asp Thr Thr Tyr Tyr
 1               5

<210> 150
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Valpha CDR2

<400> 150
Arg Asn Ser Phe Asp Glu Gln Asn
 1               5

<210> 151
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Valpha CDR3

<400> 151
Ala Leu Ser Glu Leu Ala Ser Gly Gly Ser Tyr Ile Pro Thr
 1               5                  10

<210> 152
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Valpha variable region

<400> 152
Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser Val Val Glu Lys
 1               5                  10                  15
Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg Asp Thr Thr Tyr
            20                  25                  30
Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu Leu Val Phe Leu
        35                  40                  45
Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile Ser Gly Arg Tyr
    50                  55                  60
Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn Phe Thr Ile Thr
65                  70                  75                  80
Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser Glu
                85                  90                  95
Leu Ala Ser Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser
            100                 105                 110
Leu Ile Val His Pro
        115

<210> 153
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Vbeta CDR1

<400> 153
Ala Ser Ser Phe Arg Leu Ala Gly Gly Pro Ser Thr Asp Thr Gln Tyr
 1               5                  10                  15

<210> 154
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 8 Vbeta variable region

<400> 154
Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly
 1               5                  10                  15
Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His Asp Thr Val
            20                  25                  30
Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln
        35                  40                  45
Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro Asp Arg Phe
    50                  55                  60
Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala
65                  70                  75                  80
Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Phe Arg
                85                  90                  95
Leu Ala Gly Gly Pro Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr
            100                 105                 110
Arg Leu Thr Val Leu
        115

<210> 155
<211> 177
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta1 constant domain, cysteine modified

<400> 155
Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro
 1               5                  10                  15
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu
            20                  25                  30
Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn
        35                  40                  45
Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys
    50                  55                  60
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu
65                  70                  75                  80
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys
                85                  90                  95
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp
            100                 105                 110
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg
        115                 120                 125
Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser
    130                 135                 140
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala
145                 150                 155                 160
Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp
                165                 170                 175
Phe


<210> 156
<211> 141
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha constant domain

<400> 156
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
 1               5                  10                  15
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
            20                  25                  30
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr
        35                  40                  45
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
    50                  55                  60
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
65                  70                  75                  80
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
                85                  90                  95
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
            100                 105                 110
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
        115                 120                 125
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 157
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha constant domain

<400> 157
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 158
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha constant domain, cysteine modified

<400> 158
Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
 1               5                  10                  15
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
            20                  25                  30
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
        35                  40                  45
Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
    50                  55                  60
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
65                  70                  75                  80
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
                85                  90                  95
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
            100                 105                 110
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
        115                 120                 125
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 159
<211> 141
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha constant domain, cysteine modified

<400> 159
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
 1               5                  10                  15
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
            20                  25                  30
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
        35                  40                  45
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
    50                  55                  60
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
65                  70                  75                  80
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
                85                  90                  95
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
            100                 105                 110
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
        115                 120                 125
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 160
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha constant domain, cysteine modified

<400> 160
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 161
<211> 1821
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 5 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 161
atgggcttca gactgttgtg ttgcgtggcc ttttgccttc ttggagctgg acctgtggat      60
tctggagtta cacagacccc taagcacctg attacagcca caggacagag agtgaccctg     120
agatgtagcc ctagaagcgg agatctgagc gtgtattggt accagcagag cctggatcaa     180
ggactccagt ttctgatcca gtactacaac ggcgaggaga gagccaaggg caatattctg     240
gagaggtttt ctgcccagca gttccctgat ctgcactctg aactgaacct gtctagcctg     300
gaactgggag attctgccct gtacttttgt gcctctagcg ttggacaggg cagctcttat     360
gagcagtact ttggacctgg caccagactg acagtgacag aagacctgaa gaacgtgttc     420
cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc     480
accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc     600
gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc     780
agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg     900
ctgatggcca tggtcaagcg gaaggacagc cggggcggtt ccggagccac gaacttctct     960
ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatggaaac cctgctgaaa    1020
gtgctgagcg gaacactgtt atggcagctt acatgggtga ggtctcagca acctgtgcaa    1080
tctccacagg ccgttatcct gagagaagga gaagatgccg tgatcaactg ctctagctct    1140
aaagccctgt acagcgtgca ctggtacaga cagaaacacg gagaagctcc cgtgttcctg    1200
atgattctgc tgaaaggagg cgagcagaag ggacacgaga agatttctgc cagcttcaac    1260
gagaagaagc agcagtctag cctgtacctg acagcttctc agctgagcta tagcggcacc    1320
tacttttgtg gcacagagga agccaacgac tacaaactga gctttggagc cggcacaaca    1380
gtgacagtta gagccaatat ccagaacccc gatcctgctg tgtaccagct gcgggacagc    1440
aagagcagcg acaagagcgt gtgcctgttc accgacttcg acagccagac caacgtgtcc    1500
cagagcaagg acagcgacgt gtacatcacc gataagtgcg tgctggacat gcggagcatg    1560
gacttcaaga gcaacagcgc cgtggcctgg tccaacaaga gcgacttcgc ctgcgccaac    1620
gccttcaaca acagcattat ccccgaggac acattcttcc caagccccga gagcagctgc    1680
gacgtgaagc tggtggaaaa gagcttcgag acagacacca acctgaactt ccagaacctc    1740
agcgtgatcg gcttccggat cctgctgctg aaggtggccg gcttcaacct gctgatgacc    1800
ctgcggctgt ggtccagctg a                                              1821

<210> 162
<211> 606
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 5 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 162
Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr
            20                  25                  30
Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp
        35                  40                  45
Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe
    50                  55                  60
Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu
65                  70                  75                  80
Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn
                85                  90                  95
Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Val Gly Gln Gly Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser
305                 310                 315                 320
Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu
                325                 330                 335
Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu Thr Trp
            340                 345                 350
Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile Leu Arg
        355                 360                 365
Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala Leu Tyr
    370                 375                 380
Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val Phe Leu
385                 390                 395                 400
Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys Ile Ser
                405                 410                 415
Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu Thr Ala
            420                 425                 430
Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Glu Glu Ala
        435                 440                 445
Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg
    450                 455                 460
Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
465                 470                 475                 480
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
                485                 490                 495
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
            500                 505                 510
Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
        515                 520                 525
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
    530                 535                 540
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
545                 550                 555                 560
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
                565                 570                 575
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
            580                 585                 590
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 163
<211> 1818
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 9 construct; beta chain-P2A-alpha chain

<400> 163
atggatacct ggctcgtatg ctgggcaatt tttagtctct tgaaagcagg actcacagaa      60
cctgaagtca cccagactcc cagccatcag gtcacacaga tgggacagga agtgatcttg     120
cgctgtgtcc ccatctctaa tcacttatac ttctattggt acagacaaat cttggggcag     180
aaagtcgagt ttctggtttc cttttataat aatgaaatct cagagaagtc tgaaatattc     240
gatgatcaat tctcagttga aaggcctgat ggatcaaatt tcactctgaa gatccggtcc     300
acaaagctgg aggactcagc catgtacttc tgtgccatcc tggatggaga aggttcaccc     360
ctccactttg ggaatgggac caggctcact gtgacagagg acctgaacaa ggtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttcttccct gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg     900
atggccatgg tcaagagaaa ggatttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatgaaaa agcatctgac gaccttcttg    1020
gtgattttgt ggctttattt ttataggggg aatggcaaaa accaagtgga gcagagtcct    1080
cagtccctga tcatcctgga gggaaagaac tgcactcttc aatgcaatta tacagtgagc    1140
cccttcagca acttaaggtg gtataagcaa gatactggga gaggtcctgt ttccctgaca    1200
atcatgactt tcagtgagaa cacaaagtcg aacggaagat atacagcaac tctggatgca    1260
gacacaaagc aaagctctct gcacatcaca gcctcccagc tcagcgattc agcctcctac    1320
atctgtgtgg tgtggggggg ggacaccgac aagctcatct ttgggactgg gaccagatta    1380
caagtctttc caaatatcca gaaccctgac cctgccgtgt accagctgag agactctaaa    1440
tccagtgaca agtctgtctg cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa    1500
agtaaggatt ctgatgtgta tatcacagac aaaactgtgc tagacatgag gtctatggac    1560
ttcaagagca acagtgctgt ggcctggagc aacaaatctg actttgcatg tgcaaacgcc    1620
ttcaacaaca gcattattcc agaagacacc ttcttcccca gcccagaaag ttcctgtgat    1680
gtcaagctgg tcgagaaaag ctttgaaaca gatacgaacc taaactttca aaacctgtca    1740
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg    1800
cggctgtggt ccagctga                                                  1818

<210> 164

<400> 164
 000

<210> 165
<211> 605
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 construct; beta chain-P2A-alpha chain

<400> 165
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala
 1               5                  10                  15
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr
            20                  25                  30
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His
        35                  40                  45
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe
    50                  55                  60
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe
65                  70                  75                  80
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu
                85                  90                  95
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala
            100                 105                 110
Ile Leu Asp Gly Glu Gly Ser Pro Leu His Phe Gly Asn Gly Thr Arg
        115                 120                 125
Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Lys His Leu
                325                 330                 335
Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly
            340                 345                 350
Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly
        355                 360                 365
Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn
    370                 375                 380
Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr
385                 390                 395                 400
Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala
                405                 410                 415
Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser
            420                 425                 430
Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Trp Gly Gly Asp
        435                 440                 445
Thr Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro
    450                 455                 460
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
465                 470                 475                 480
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
                485                 490                 495
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr
            500                 505                 510
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
        515                 520                 525
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
    530                 535                 540
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
545                 550                 555                 560
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
                565                 570                 575
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
            580                 585                 590
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 166
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 Vbeta variable region

<400> 166
Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly
 1               5                  10                  15
Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe
            20                  25                  30
Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser
        35                  40                  45
Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln
    50                  55                  60
Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg
65                  70                  75                  80
Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ile Leu Asp
                85                  90                  95
Gly Glu Gly Ser Pro Leu His Phe Gly Asn Gly Thr Arg Leu Thr Val
            100                 105                 110
Thr


<210> 167
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 Vbeta CDR1

<400> 167
Ser Asn His Leu Tyr Phe
 1               5

<210> 168
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 Vbeta CDR2

<400> 168
Phe Tyr Asn Asn Glu Ile
 1               5

<210> 169
<211> 1818
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 9 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 169
atggatacct ggctcgtgtg ttgggccatc ttttctctgc tgaaagccgg actgaccgaa      60
cctgaagtta cacaaacccc tagccaccag gtgacacaaa tgggacagga ggtgatcctg     120
agatgtgtgc ctatcagcaa ccacctgtac ttctactggt accggcagat tctgggccag     180
aaagtggagt ttctggtgag cttctacaac aacgagatca gcgagaagag cgagatcttc     240
gatgaccagt tcagcgtgga gagaccagat ggaagcaact ttaccctgaa gatccggagc     300
accaagctgg aagattctgc catgtacttc tgcgccatcc tggatggaga gggatctcct     360
ctgcactttg gcaatggcac aagactgacc gtgacagaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatct cccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcactccgg cgtgtgcacc gatccccagc ctctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc cacaatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatgaaga agcacctgac cacgttcctg    1020
gtgattcttt ggctgtactt ctaccggggc aacggcaaaa atcaggtgga acaaagcccc    1080
cagagcctga ttattctgga gggcaagaac tgcaccctcc agtgtaatta caccgtgagc    1140
cctttcagca acctgagatg gtacaagcag gataccggaa gaggacctgt gtctctgacc    1200
atcatgacct ttagcgagaa caccaagagc aacggcaggt atacagccac actggatgcc    1260
gataccaagc agtcttctct gcacattacc gcctctcagc tgtctgattc tgccagctac    1320
atctgtgtgg tgtggggagg agataccgat aagctgatct ttggcacagg caccagactg    1380
caagtgttcc ctaacatcca gaaccctgat cctgccgtgt accagctgcg ggacagcaag    1440
agcagcgaca agagcgtgtg cctgttcacc gacttcgaca gccagaccaa cgtgtcccag    1500
agcaaggaca gcgacgtgta catcaccgat aagtgcgtgc tggacatgcg gagcatggac    1560
ttcaagagca acagcgccgt ggcctggtcc aacaagagcg acttcgcctg cgccaacgcc    1620
ttcaacaaca gcattatccc cgaggacaca ttcttcccaa gccccgagag cagctgcgac    1680
gtgaagctgg tggaaaagag cttcgagaca gacaccaacc tgaacttcca gaacctcagc    1740
gtgatcggct tccggatcct gctgctgaag gtggccggct tcaacctgct gatgaccctg    1800
cggctgtggt ccagctga                                                  1818

<210> 170
<211> 605
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 9 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 170
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala
 1               5                  10                  15
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr
            20                  25                  30
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His
        35                  40                  45
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe
    50                  55                  60
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe
65                  70                  75                  80
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu
                85                  90                  95
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala
            100                 105                 110
Ile Leu Asp Gly Glu Gly Ser Pro Leu His Phe Gly Asn Gly Thr Arg
        115                 120                 125
Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Lys His Leu
                325                 330                 335
Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly
            340                 345                 350
Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly
        355                 360                 365
Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn
    370                 375                 380
Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr
385                 390                 395                 400
Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala
                405                 410                 415
Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser
            420                 425                 430
Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Trp Gly Gly Asp
        435                 440                 445
Thr Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro
    450                 455                 460
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
465                 470                 475                 480
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
                485                 490                 495
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
            500                 505                 510
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
        515                 520                 525
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
    530                 535                 540
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
545                 550                 555                 560
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
                565                 570                 575
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
            580                 585                 590
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 171
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 6 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 171
atgagcatca gcctcctgtg ctgtgcagcc tttcctctcc tgtgggcagg tccagtgaat      60
gctggtgtca ctcagacccc aaaattccgc atcctgaaga taggacagag catgacactg     120
cagtgtaccc aggatatgaa ccataactac atgtactggt atcgacaaga cccaggcatg     180
gggctgaagc tgatttatta ttcagttggt gctggtatca ctgataaagg agaagtcccg     240
aatggctaca acgtctccag atcaaccaca gaggatttcc cgctcaggct ggagttggct     300
gctccctccc agacatctgt gtacttctgt gccagcagtg acaggtctaa caccggggag     360
ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca     420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca     480
ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat     540
gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc     600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     720
tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga     780
gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc     840
tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg     900
atggccatgg tcaagagaaa ggattccaga ggcggttccg gagccacgaa cttctctctg     960
ttaaagcaag caggagacgt ggaagaaaac cccggtccca tggagaagaa tcctttggca    1020
gccccattac taatcctctg gtttcatctt gactgcgtga gcagcatact gaacgtggaa    1080
caaagtcctc agtcactgca tgttcaggag ggagacagca ccaatttcac ctgcagcttc    1140
ccttccagca atttttatgc cttacactgg tacagatggg aaactgcaaa aagccccgag    1200
gccttgtttg taatgacttt aaatggggat gaaaagaaga aaggacgaat aagtgccact    1260
cttaatacca aggagggtta cagctatttg tacatcaaag gatcccagcc tgaagactca    1320
gccacatacc tctgtgcctt agggccttat aacgactaca agctcagctt tggagccgga    1380
accacagtaa ctgtaagagc aaatatccag aaccctgacc ctgccgtgta ccagctgcgg    1440
gacagcaaga gcagcgacaa gagcgtgtgc ctgttcaccg acttcgacag ccagaccaac    1500
gtgtcccaga gcaaggacag cgacgtgtac atcaccgata agtgcgtgct ggacatgcgg    1560
agcatggact tcaagagcaa cagcgccgtg gcctggtcca acaagagcga cttcgcctgc    1620
gccaacgcct tcaacaacag cattatcccc gaggacacat tcttcccaag ccccgagagc    1680
agctgcgacg tgaagctggt ggaaaagagc ttcgagacag acaccaacct gaacttccag    1740
aacctcagcg tgatcggctt ccggatcctg ctgctgaagg tggccggctt caacctgctg    1800
atgaccctgc ggctgtggtc cagctga                                        1827

<210> 172
<211> 608
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 6 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 172
Met Ser Ile Ser Leu Leu Cys Cys Ala Ala Phe Pro Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Ile Leu
            20                  25                  30
Lys Ile Gly Gln Ser Met Thr Leu Gln Cys Thr Gln Asp Met Asn His
        35                  40                  45
Asn Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Lys Leu
    50                  55                  60
Ile Tyr Tyr Ser Val Gly Ala Gly Ile Thr Asp Lys Gly Glu Val Pro
65                  70                  75                  80
Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg
                85                  90                  95
Leu Glu Leu Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Asp Arg Ser Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg
        115                 120                 125
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu
305                 310                 315                 320
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Lys
                325                 330                 335
Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His Leu Asp Cys
            340                 345                 350
Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val
        355                 360                 365
Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn
    370                 375                 380
Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu
385                 390                 395                 400
Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg
                405                 410                 415
Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile
            420                 425                 430
Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Gly
        435                 440                 445
Pro Tyr Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr
    450                 455                 460
Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
465                 470                 475                 480
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
                485                 490                 495
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
            500                 505                 510
Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
        515                 520                 525
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
    530                 535                 540
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
545                 550                 555                 560
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
                565                 570                 575
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
            580                 585                 590
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 173
<211> 1815
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 1 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 173
atgggacctg gactgctttg ttgggctctt ctgtgtctgc ttggagctgg actggttgat      60
gctggagtta cacagagccc tacacacctg atcaagacaa gaggacagca ggtgaccctg     120
agatgtagcc ctaaatctgg ccacgatacc gtgagctggt atcaacaggc tctgggacaa     180
ggacctcagt tcatcttcca gtactacgag gaggaggaga gacagagagg caatttccct     240
gacaggttta gcggacacca gttccccaat tacagctctg agctgaacgt gaatgccctt     300
cttctgggag attctgccct gtatctgtgt gccagcagct tctttagcca ggaaacccag     360
tacttcggcc caggaacaag actgctggtt cttgaagacc tgaagaacgt gttcccccca     420
gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc     480
gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg     600
aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac     660
ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg     720
acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc     780
gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac     840
gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg     900
gccatggtca agcggaagga cagccggggc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatgg aaaccctgtt aggcctgctc    1020
attctgtggt tacagctcca atgggtgagc agcaaacagg aagtgaccca gattcctgct    1080
gccttatctg tgcctgaagg cgaaaatctg gtgctgaatt gcagcttcac cgattctgcc    1140
atctacaacc tccagtggtt cagacaggat ccaggaaaag gcctgacatc tcttctgctg    1200
atccagtcta gccagagaga gcagacaagc ggaagactga atgcctctct ggacaagagc    1260
agcggaagat ctaccctgta tattgccgcc tctcagcctg gagattctgc cacatatctg    1320
tgtgccgtgg agggagatag cagctataag ctgatcttcg gcagcggcac aagattactg    1380
gtgagacctg acatccagaa ccctgatcct gctgtgtacc agctgcggga cagcaagagc    1440
agcgacaaga gcgtgtgcct gttcaccgac ttcgacagcc agaccaacgt gtcccagagc    1500
aaggacagcg acgtgtacat caccgataag tgcgtgctgg acatgcggag catggacttc    1560
aagagcaaca gcgccgtggc ctggtccaac aagagcgact tcgcctgcgc caacgccttc    1620
aacaacagca ttatccccga ggacacattc ttcccaagcc ccgagagcag ctgcgacgtg    1680
aagctggtgg aaaagagctt cgagacagac accaacctga acttccagaa cctcagcgtg    1740
atcggcttcc ggatcctgct gctgaaggtg gccggcttca acctgctgat gaccctgcgg    1800
ctgtggtcca gctga                                                     1815

<210> 174
<211> 604
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 1 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 174
Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His
        35                  40                  45
Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro
65                  70                  75                  80
Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Phe Phe Ser Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
305                 310                 315                 320
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Leu
                325                 330                 335
Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp Val Ser Ser Lys
            340                 345                 350
Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly Glu
        355                 360                 365
Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn Leu
    370                 375                 380
Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu Leu
385                 390                 395                 400
Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala Ser
                405                 410                 415
Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser Gln
            420                 425                 430
Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Glu Gly Asp Ser Ser
        435                 440                 445
Tyr Lys Leu Ile Phe Gly Ser Gly Thr Arg Leu Leu Val Arg Pro Asp
    450                 455                 460
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
465                 470                 475                 480
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
                485                 490                 495
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
            500                 505                 510
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
        515                 520                 525
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
    530                 535                 540
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
545                 550                 555                 560
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
                565                 570                 575
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
            580                 585                 590
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 175
<211> 1824
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 2 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 175
atgggcacca gactgctgtg ttgggctgct ctgtgtctgc tgggagccga tcatacaggt      60
gccggtgtca gccagacacc tagcaacaaa gtgaccgaga agggcaaata cgtggaactg     120
agatgcgacc ccatcagcgg acacacagcc ctgtactggt acagacagtc tctcggccag     180
ggacctgagt tcctgatcta cttccaaggc accggcgctg ccgatgatag cggcctgcct     240
aacgatagat tcttcgccgt cagacccgag ggcagcgtgt ccacactgaa gatccagaga     300
accgagaggg gcgacagcgc cgtgtatctg tgtgcctctt ctctgtctgg cctcggctct     360
ggcgctaacg tgctgacatt tggcgccgga agcagactga ccgtgctgga agatctgaag     420
aacgtgttcc cacctgaggt ggccgtgttc gagccttctg aggccgagat cagccacaca     480
cagaaagcca cactcgtgtg tctggccacc ggcttctatc ccgaccatgt ggaactgtct     540
tggtgggtca acggcaaaga ggtgcacagc ggcgtctgta cagatcccca gcctctgaaa     600
gaacagcccg ctctgaacga cagccggtac tgtctgtcct ccagactgag agtgtccgcc     660
accttctggc agaaccccag aaaccacttc agatgccagg tgcagttcta cggcctgagc     720
gagaacgatg agtggaccca ggatagagcc aagcctgtga cacagatcgt gtctgccgaa     780
gcctggggca gagccgattg tggctttacc agcgagagct accagcaggg cgtgctgtct     840
gccacaatcc tgtacgagat cctgctgggc aaagccactc tgtacgccgt gctggtgtct     900
gccctggtgc tgatggccat ggtcaagcgg aaggacagca gaggcggttc cggagccacg     960
aacttctctc tgttaaagca agcaggagac gtggaagaaa accccggtcc catggaaaca    1020
ctgctgggcc tgctgatcct gtggctgcaa ctgcaatggg tgtccagcaa gcaagaagtg    1080
acacagatcc ctgccgctct gtctgtgcct gagggcgaaa acctggtgct gaactgcagc    1140
ttcaccgaca gcgccatcta caacctgcag tggttcagac aggaccccgg caagggactg    1200
acaagcctgc tgctgattca gagcagccag agagagcaga ccagcggcag actgaatgcc    1260
agcctggata agtcctccgg cagaagcacc ctgtatatcg ccgcttctca gcctggcgat    1320
agcgccacat atctgtgtgc cgtgatcggc gagcagaact tcgtgtttgg ccctggcaca    1380
agactgagcg tgctgcccta cattcagaac cccgatcctg ccgtgtacca gctgcgggac    1440
agcaagagca gcgacaagag cgtgtgcctg ttcaccgact tcgacagcca gaccaacgtg    1500
tcccagagca aggacagcga cgtgtacatc accgataagt gcgtgctgga catgcggagc    1560
atggacttca agagcaacag cgccgtggcc tggtccaaca agagcgactt cgcctgcgcc    1620
aacgccttca acaacagcat tatccccgag gacacattct tcccaagccc cgagagcagc    1680
tgcgacgtga agctggtgga aaagagcttc gagacagaca ccaacctgaa cttccagaac    1740
ctcagcgtga tcggcttccg gatcctgctg ctgaaggtgg ccggcttcaa cctgctgatg    1800
accctgcggc tgtggtccag ctga                                           1824

<210> 176
<211> 607
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 2 construct
      polypeptide; beta chain-P2A-alpha chain with
      cysteine substitutions in beta and alpha chain
      constant domains

<400> 176
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr
            20                  25                  30
Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu
                85                  90                  95
Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Ser Gly Leu Gly Ser Gly Ala Asn Val Leu Thr Phe Gly
        115                 120                 125
Ala Gly Ser Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro
    130                 135                 140
Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr
145                 150                 155                 160
Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His
                165                 170                 175
Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val
            180                 185                 190
Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser
        195                 200                 205
Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln
    210                 215                 220
Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser
225                 230                 235                 240
Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile
                245                 250                 255
Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu
            260                 265                 270
Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu
        275                 280                 285
Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu
    290                 295                 300
Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr
305                 310                 315                 320
Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly
                325                 330                 335
Pro Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln
            340                 345                 350
Trp Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser
        355                 360                 365
Val Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser
    370                 375                 380
Ala Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu
385                 390                 395                 400
Thr Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly
                405                 410                 415
Arg Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr
            420                 425                 430
Ile Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val
        435                 440                 445
Ile Gly Glu Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val
    450                 455                 460
Leu Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp
465                 470                 475                 480
Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser
                485                 490                 495
Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp
            500                 505                 510
Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala
        515                 520                 525
Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn
    530                 535                 540
Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser
545                 550                 555                 560
Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu
                565                 570                 575
Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys
            580                 585                 590
Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 177
<211> 1818
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 3 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 177
atgggcacca gactgctgtg ttgggccgct ctgtgtctgc tgggcgccga tcatacaggc      60
gctggcgtgt cccagacccc cagcaacaaa gtgaccgaga agggcaaata cgtggaactg     120
agatgcgacc ccatcagcgg ccacaccgcc ctgtactggt acagacagtc tctgggccag     180
ggccccgagt tcctgatata ttttcagggc accggcgctg ccgacgacag cggcctgcct     240
aacgatagat tcttcgccgt gcggcccgag ggcagcgtgt ccacactgaa gatccagaga     300
accgagcggg gcgacagcgc cgtgtatctg tgtgccagca gcctgaatat gaacaccgag     360
gcattctttg ggcagggcac ccggctgacc gtggtggaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatca gccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccatgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg agtgtgcacc gaccctcagc ccctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgacc cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc caccatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatgatga agtccctgcg ggtgctgctc    1020
gtgatcctgt ggctgcagct gtcttgggtg tggtcccagc agaaagaggt ggaacagaac    1080
agcggccctc tgagcgtgcc agagggcgcc attgctagcc tgaattgcac ctacagcgac    1140
cggggcagcc agagcttctt ctggtatcgg cagtacagcg gcaagagccc cgagctgatc    1200
atgagcatct acagcaacgg cgacaaagag gacggccggt tcaccgccca gctgaacaaa    1260
gccagccagt acgtgtcact gctgatccgg gacagccagc ccagcgatag cgccacatac    1320
ctgtgcgccg tggatagcgg cggctaccag aaagtgacct tcggcaccgg caccaagctg    1380
caagtgatcc ccaacatcca gaaccccgac cccgctgtgt accagctgcg ggacagcaag    1440
agcagcgaca agagcgtgtg cctgttcacc gacttcgaca gccagaccaa cgtgtcccag    1500
agcaaggaca gcgacgtgta catcaccgat aagtgcgtgc tggacatgcg gagcatggac    1560
ttcaagagca acagcgccgt ggcctggtcc aacaagagcg acttcgcctg cgccaacgcc    1620
ttcaacaaca gcattatccc cgaggacaca ttcttcccaa gccccgagag cagctgcgac    1680
gtgaagctgg tggaaaagag cttcgagaca gacaccaacc tgaacttcca gaacctcagc    1740
gtgatcggct tccggatcct gctgctgaag gtggccggct tcaacctgct gatgaccctg    1800
cggctgtggt ccagctga                                                  1818

<210> 178
<211> 605
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 3 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 178
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr
            20                  25                  30
Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu
                85                  90                  95
Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Asn Met Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Met Lys Ser Leu
                325                 330                 335
Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser
            340                 345                 350
Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu
        355                 360                 365
Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln
    370                 375                 380
Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile
385                 390                 395                 400
Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala
                405                 410                 415
Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser
            420                 425                 430
Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asp Ser Gly Gly
        435                 440                 445
Tyr Gln Lys Val Thr Phe Gly Thr Gly Thr Lys Leu Gln Val Ile Pro
    450                 455                 460
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
465                 470                 475                 480
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
                485                 490                 495
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
            500                 505                 510
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
        515                 520                 525
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
    530                 535                 540
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
545                 550                 555                 560
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
                565                 570                 575
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
            580                 585                 590
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 179
<211> 1812
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 10 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 179
atgggcacca gactgctgtg ttgggccgct ctgtgtctgc tgggcgccga tcatacaggc      60
gctggcgtgt cccagacccc cagcaacaaa gtgaccgaga agggcaaata cgtggaactg     120
agatgcgacc ccatcagcgg ccacaccgcc ctgtactggt acagacagtc tctgggccag     180
ggccccgagt tcctgatata ttttcagggc accggcgctg ccgacgacag cggcctgcct     240
aacgatagat tcttcgccgt gcggcccgag ggcagcgtgt ccacactgaa gatccagaga     300
accgagcggg gcgacagcgc cgtgtatctg tgtgccagca gcctgaatat gaacaccgag     360
gcattctttg ggcagggcac ccggctgacc gtggtggaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatca gccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccatgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcacagcgg agtgtgcacc gaccctcagc ccctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgacc cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc caccatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatggaaa ccctgctggg agtgtccctc    1020
gtgatcctgt ggctgcagct ggccagagtg aacagccagc agggggaaga ggatccccag    1080
gccctgagca ttcaggaagg cgagaacgcc accatgaact gcagctacaa gaccagcatc    1140
aacaacctgc agtggtacag gcagaacagc ggcagaggcc tggtgcacct gatcctgatc    1200
agaagcaacg agagagagaa gcactccgga cggctgagag tgaccctgga cacctccaag    1260
aagtcctcca gcctgctgat caccgccagc agagccgccg ataccgccag ctacttctgc    1320
gccacagacg agagcagcaa ctacaagctg accttcggca agggcacact gctgacagtg    1380
aaccccaaca tccagaaccc cgaccccgct gtgtaccagc tgcgggacag caagagcagc    1440
gacaagagcg tgtgcctgtt caccgacttc gacagccaga ccaacgtgtc ccagagcaag    1500
gacagcgacg tgtacatcac cgataagtgc gtgctggaca tgcggagcat ggacttcaag    1560
agcaacagcg ccgtggcctg gtccaacaag agcgacttcg cctgcgccaa cgccttcaac    1620
aacagcatta tccccgagga cacattcttc ccaagccccg agagcagctg cgacgtgaag    1680
ctggtggaaa agagcttcga gacagacacc aacctgaact tccagaacct cagcgtgatc    1740
ggcttccgga tcctgctgct gaaggtggcc ggcttcaacc tgctgatgac cctgcggctg    1800
tggtccagct ga                                                        1812

<210> 180
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 10 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 180
Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr
            20                  25                  30
Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His
        35                  40                  45
Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro
65                  70                  75                  80
Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu
                85                  90                  95
Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Leu Asn Met Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Leu Leu
                325                 330                 335
Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu Ala Arg Val Asn Ser
            340                 345                 350
Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu
        355                 360                 365
Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln
    370                 375                 380
Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile
385                 390                 395                 400
Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr Leu
                405                 410                 415
Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala
            420                 425                 430
Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Glu Ser Ser Asn Tyr
        435                 440                 445
Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu Thr Val Asn Pro Asn Ile
    450                 455                 460
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
465                 470                 475                 480
Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val
                485                 490                 495
Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu
            500                 505                 510
Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser
        515                 520                 525
Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile
    530                 535                 540
Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys
545                 550                 555                 560
Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn
                565                 570                 575
Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe
            580                 585                 590
Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 181
<211> 1818
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 7 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 181
atgagcaacc aggtcttgtg ctgtgtggtg ctgtgctttc ttggcgccaa tacagtggat      60
ggcggcatta cacagagccc taagtacctg ttccggaaag aaggccagaa cgtgacactg     120
tcttgcgagc aaaacctgaa ccacgatgcc atgtactggt acagacagga tcctggacag     180
ggacttaggc tgatctacta tagccagatc gtgaacgact tccagaaggg cgatattgcc     240
gagggctatt ctgtgtctcg ggagaaaaag gagagcttcc ctctgacagt gacatctgcc     300
cagaagaatc ctaccgcctt ctacctttgt gccagctctc tgaatcgggg cagatacgga     360
tacacctttg gatctggcac cagactgaca gtggtggaag atctgaacaa ggtgttcccc     420
ccagaggtgg ccgtgttcga gccttctgag gccgagatct cccacaccca gaaagccacc     480
ctcgtgtgcc tggccaccgg ctttttcccc gaccacgtgg aactgtcttg gtgggtcaac     540
ggcaaagagg tgcactccgg cgtgtgcacc gatccccagc ctctgaaaga acagcccgcc     600
ctgaacgaca gccggtactg cctgagcagc agactgagag tgtccgccac cttctggcag     660
aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag     720
tggacccagg acagagccaa gcccgtgaca cagatcgtgt ctgccgaagc ctggggcaga     780
gccgattgcg gctttacctc cgtgtcctat cagcagggcg tgctgagcgc cacaatcctg     840
tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtctgc cctggtgctg     900
atggccatgg tcaagcggaa ggacttcggt tccggagcca cgaacttctc tctgttaaag     960
caagcaggag acgtggaaga aaaccccggt cccatggaga agaaccccct tgcagcacct    1020
ctgcttattc tgtggttcca cctggattgc gtgagctcta tcctgaatgt ggagcagtct    1080
cctcagtctc tgcatgttca ggaaggcgat agcaccaact tcacctgtag ctttcccagc    1140
agcaacttct atgccctgca ctggtacaga tgggaaacag ccaaaagccc tgaagccctg    1200
ttcgtgatga cccttaatgg cgatgagaag aagaagggcc ggatttctgc caccctgaat    1260
acaaaagagg gctacagcta cctgtacatc aagggatctc agcctgagga tagcgccaca    1320
tatctgtgtg cctatctggg agccggcaat cagttctatt tcggaacagg caccagcctg    1380
accgtgattc ctaatatcca gaaccccgat cctgccgtgt accagctgcg ggacagcaag    1440
agcagcgaca agagcgtgtg cctgttcacc gacttcgaca gccagaccaa cgtgtcccag    1500
agcaaggaca gcgacgtgta catcaccgat aagtgcgtgc tggacatgcg gagcatggac    1560
ttcaagagca acagcgccgt ggcctggtcc aacaagagcg acttcgcctg cgccaacgcc    1620
ttcaacaaca gcattatccc cgaggacaca ttcttcccaa gccccgagag cagctgcgac    1680
gtgaagctgg tggaaaagag cttcgagaca gacaccaacc tgaacttcca gaacctcagc    1740
gtgatcggct tccggatcct gctgctgaag gtggccggct tcaacctgct gatgaccctg    1800
cggctgtggt ccagctga                                                  1818

<210> 182
<211> 605
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 7 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 182
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Leu Asn Arg Gly Arg Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg
        115                 120                 125
Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala
    130                 135                 140
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160
Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser
                165                 170                 175
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
            180                 185                 190
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300
Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys
305                 310                 315                 320
Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Lys Asn Pro
                325                 330                 335
Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser
            340                 345                 350
Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu
        355                 360                 365
Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr
    370                 375                 380
Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu
385                 390                 395                 400
Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser
                405                 410                 415
Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly
            420                 425                 430
Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Tyr Leu Gly Ala
        435                 440                 445
Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro
    450                 455                 460
Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys
465                 470                 475                 480
Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr
                485                 490                 495
Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys
            500                 505                 510
Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala
        515                 520                 525
Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser
    530                 535                 540
Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp
545                 550                 555                 560
Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe
                565                 570                 575
Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala
            580                 585                 590
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 183
<211> 1848
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 8 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 183
atgggacctg gactgctttg ttgggctctt ctgtgtctgc ttggagctgg actggttgat      60
gctggagtta cacagagccc tacacacctg atcaagacaa gaggacagca ggtgaccctg     120
agatgtagcc ctaaatctgg ccacgatacc gtgagctggt atcaacaggc tctgggacaa     180
ggacctcagt tcatcttcca gtactacgag gaggaggaga gacagagagg caatttccct     240
gacaggttta gcggacacca gttccccaat tacagctctg agctgaacgt gaatgccctt     300
cttctgggag attctgccct gtatctgtgt gccagcagct ttagactggc tggaggacct     360
agcaccgata cacagtattt tggacctggc accaggctga cagtgttaga agacctgaag     420
aacgtgttcc ccccagaggt ggccgtgttc gagcctagcg aggccgagat cagccacacc     480
cagaaagcca ccctcgtgtg cctggccacc ggcttttacc ccgaccacgt ggaactgtct     540
tggtgggtca acggcaaaga ggtgcacagc ggcgtctgca ccgaccccca gcccctgaaa     600
gagcagcccg ccctgaacga cagccggtac tgtctgagca gcagactgag agtgtccgcc     660
accttctggc agaacccccg gaaccacttc agatgccagg tgcagttcta cggcctgagc     720
gagaacgacg agtggaccca ggaccgggcc aagcccgtga cccagatcgt gtctgctgag     780
gcctggggca gagccgattg cggcttcacc agcgagagct accagcaggg cgtgctgagc     840
gccaccatcc tgtacgagat cctgctgggc aaggccaccc tgtacgccgt gctggtgtcc     900
gccctggtgc tgatggccat ggtcaagcgg aaggacagcc ggggcggttc cggagccacg     960
aacttctctc tgttaaagca agcaggagac gtggaagaaa accccggtcc catgttgacc    1020
gcttctctct tacgtgccgt gattgccagc atctgtgtgg ttagctctat ggcccagaag    1080
gtgacacaag ctcagacaga gatcagcgtg gtggagaaag aggatgtgac cctggattgc    1140
gtgtacgaga ccagagatac cacctactac ctgttctggt acaagcagcc tccttctgga    1200
gaactggtgt tcctgatcag acggaacagc ttcgatgagc agaacgagat tagcggcagg    1260
tatagctgga acttccagaa gagcaccagc agcttcaact tcaccatcac agcctctcag    1320
gtggtggatt ctgccgtgta cttttgtgcc ctgtctgaac tggcctctgg aggaagctat    1380
atccctacat tcggcagagg cacaagcctg attgtgcacc cttacatcca gaaccctgat    1440
cctgctgtgt accagctgcg ggacagcaag agcagcgaca agagcgtgtg cctgttcacc    1500
gacttcgaca gccagaccaa cgtgtcccag agcaaggaca gcgacgtgta catcaccgat    1560
aagtgcgtgc tggacatgcg gagcatggac ttcaagagca acagcgccgt ggcctggtcc    1620
aacaagagcg acttcgcctg cgccaacgcc ttcaacaaca gcattatccc cgaggacaca    1680
ttcttcccaa gccccgagag cagctgcgac gtgaagctgg tggaaaagag cttcgagaca    1740
gacaccaacc tgaacttcca gaacctcagc gtgatcggct tccggatcct gctgctgaag    1800
gtggccggct tcaacctgct gatgaccctg cggctgtggt ccagctga                 1848

<210> 184
<211> 615
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 8 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 184
Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys
            20                  25                  30
Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His
        35                  40                  45
Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe
    50                  55                  60
Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro
65                  70                  75                  80
Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn
                85                  90                  95
Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Phe Arg Leu Ala Gly Gly Pro Ser Thr Asp Thr Gln Tyr Phe Gly
        115                 120                 125
Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro
    130                 135                 140
Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr
145                 150                 155                 160
Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His
                165                 170                 175
Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val
            180                 185                 190
Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser
        195                 200                 205
Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln
    210                 215                 220
Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser
225                 230                 235                 240
Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile
                245                 250                 255
Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu
            260                 265                 270
Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu
        275                 280                 285
Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu
    290                 295                 300
Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr
305                 310                 315                 320
Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly
                325                 330                 335
Pro Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys
            340                 345                 350
Val Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile
        355                 360                 365
Ser Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr
    370                 375                 380
Arg Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly
385                 390                 395                 400
Glu Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu
                405                 410                 415
Ile Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe
            420                 425                 430
Asn Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe
        435                 440                 445
Cys Ala Leu Ser Glu Leu Ala Ser Gly Gly Ser Tyr Ile Pro Thr Phe
    450                 455                 460
Gly Arg Gly Thr Ser Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp
465                 470                 475                 480
Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val
                485                 490                 495
Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys
            500                 505                 510
Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser
        515                 520                 525
Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp
    530                 535                 540
Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr
545                 550                 555                 560
Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys
                565                 570                 575
Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile
            580                 585                 590
Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met
        595                 600                 605
Thr Leu Arg Leu Trp Ser Ser
    610                 615

<210> 185
<211> 1815
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR number 11 construct; beta chain-P2A-alpha
      chain

<400> 185
atgggcacca ggctcttctt ctatgtggcc ctttgtctgc tgtgggcagg acacagggat      60
gctggaatca cccagagccc aagatacaag atcacagaga caggaaggca ggtgaccttg     120
atgtgtcacc agacttggag ccacagctat atgttctggt atcgacaaga cctgggacat     180
gggctgaggc tgatctatta ctcagcagct gctgatatta cagataaagg agaagtcccc     240
gatggctatg ttgtctccag atccaagaca gagaatttcc ccctcactct ggagtcagct     300
acccgctccc agacatctgt gtatttctgc gccagcagtg acgggggcgg gcagtacttc     360
gggccgggca ccaggctcac ggtcacagag gacctgaaaa acgtgttccc acccgaggtc     420
gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc     480
ctggccacag gcttctaccc cgaccacgtg gagctgagct ggtgggtgaa tgggaaggag     540
gtgcacagtg gggtcagcac agacccgcag cccctcaagg agcagcccgc cctcaatgac     600
tccagatact gcctgagcag ccgcctgagg gtctcggcca ccttctggca gaacccccgc     660
aaccacttcc gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag     720
gatagggcca aacctgtcac ccagatcgtc agcgccgagg cctggggtag agcagactgt     780
ggcttcacct ccgagtctta ccagcaaggg gtcctgtctg ccaccatcct ctatgagatc     840
ttgctaggga aggccacctt gtatgccgtg ctggtcagtg ccctcgtgct gatggccatg     900
gtcaagagaa aggattccag aggcggttcc ggagccacga acttctctct gttaaagcaa     960
gcaggagacg tggaagaaaa ccccggtccc atgaaaaagc atctgacgac cttcttggtg    1020
attttgtggc tttattttta tagggggaat ggcaaaaacc aagtggagca gagtcctcag    1080
tccctgatca tcctggaggg aaagaactgc actcttcaat gcaattatac agtgagcccc    1140
ttcagcaact taaggtggta taagcaagat actgggagag gtcctgtttc cctgacaatc    1200
atgactttca gtgagaacac aaagtcgaac ggaagatata cagcaactct ggatgcagac    1260
acaaagcaaa gctctctgca catcacagcc tcccagctca gcgattcagc ctcctacatc    1320
tgtgtggtgt ggggggggga caccgacaag ctcatctttg ggactgggac cagattacaa    1380
gtctttccaa atatccagaa ccctgaccct gccgtgtacc agctgagaga ctctaaatcc    1440
agtgacaagt ctgtctgcct attcaccgat tttgattctc aaacaaatgt gtcacaaagt    1500
aaggattctg atgtgtatat cacagacaaa acttggctag acatgaggtc tatggacttc    1560
aagagcaaca gtgctgtggc ctggagcaac aaatctgact ttgcatgtgc aaacgccttc    1620
aacaacagca ttattccaga agacaccttc ttccccagcc cagaaagttc ctgtgatgtc    1680
aagctggtcg agaaaagctt tgaaacagat acgaacctaa actttcaaaa cctgtcagtg    1740
attgggttcc gaatcctcct cctgaaagtg gccgggttta atctgctcat gacgctgcgg    1800
ctgtggtcca gctga                                                     1815

<210> 186
<211> 604
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 11 construct; beta chain-P2A-alpha
      chain

<400> 186
Met Gly Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Ala
 1               5                  10                  15
Gly His Arg Asp Ala Gly Ile Thr Gln Ser Pro Arg Tyr Lys Ile Thr
            20                  25                  30
Glu Thr Gly Arg Gln Val Thr Leu Met Cys His Gln Thr Trp Ser His
        35                  40                  45
Ser Tyr Met Phe Trp Tyr Arg Gln Asp Leu Gly His Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Ala Ala Ala Asp Ile Thr Asp Lys Gly Glu Val Pro
65                  70                  75                  80
Asp Gly Tyr Val Val Ser Arg Ser Lys Thr Glu Asn Phe Pro Leu Thr
                85                  90                  95
Leu Glu Ser Ala Thr Arg Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Asp Gly Gly Gly Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val
        115                 120                 125
Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu
    130                 135                 140
Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys
145                 150                 155                 160
Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val
                165                 170                 175
Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu
            180                 185                 190
Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg
        195                 200                 205
Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg
    210                 215                 220
Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln
225                 230                 235                 240
Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly
                245                 250                 255
Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu
            260                 265                 270
Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr
        275                 280                 285
Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys
    290                 295                 300
Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln
305                 310                 315                 320
Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Lys His Leu Thr
                325                 330                 335
Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly Lys
            340                 345                 350
Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly Lys
        355                 360                 365
Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn Leu
    370                 375                 380
Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr Ile
385                 390                 395                 400
Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala Thr
                405                 410                 415
Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser Gln
            420                 425                 430
Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Trp Gly Gly Asp Thr
        435                 440                 445
Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn
    450                 455                 460
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
465                 470                 475                 480
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
                485                 490                 495
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Trp
            500                 505                 510
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
        515                 520                 525
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
    530                 535                 540
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
545                 550                 555                 560
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
                565                 570                 575
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
            580                 585                 590
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 187
<211> 1812
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 11 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 187
atgggcacac ggcttttctt ctacgttgcc ctttgcctgc tgtgggctgg acatagagat      60
gctggaatca cacagagccc caggtacaag atcacagaga caggaagaca ggtgaccctg     120
atgtgtcacc aaacatggag ccacagctac atgttctggt acagacagga tctgggacac     180
ggactgagac tgatctacta ttctgctgcc gccgacatca ccgataaagg agaagttcct     240
gacggctacg tggtgtctag aagcaaaacc gagaacttcc ccctgacact ggaatctgcc     300
acaagatctc agaccagcgt gtacttttgc gcctcttctg atggaggagg ccagtatttt     360
ccaggcacaa gactgacagt gaccgaggac ctgaagaacg tgttcccccc agaggtggcc     420
gtgttcgagc ctagcgaggc cgagatcagc cacacccaga aagccaccct cgtgtgcctg     480
gccaccggct tttaccccga ccacgtggaa ctgtcttggt gggtcaacgg caaagaggtg     540
cacagcggcg tctgcaccga cccccagccc ctgaaagagc agcccgccct gaacgacagc     600
cggtactgtc tgagcagcag actgagagtg tccgccacct tctggcagaa cccccggaac     660
cacttcagat gccaggtgca gttctacggc ctgagcgaga acgacgagtg gacccaggac     720
cgggccaagc ccgtgaccca gatcgtgtct gctgaggcct ggggcagagc cgattgcggc     780
ttcaccagcg agagctacca gcagggcgtg ctgagcgcca ccatcctgta cgagatcctg     840
ctgggcaagg ccaccctgta cgccgtgctg gtgtccgccc tggtgctgat ggccatggtc     900
aagcggaagg acagccgggg cggttccgga gccacgaact tctctctgtt aaagcaagca     960
ggagacgtgg aagaaaaccc cggtcccatg aagaagcacc tgaccacgtt cctggtgatt    1020
ctttggctgt acttctaccg gggcaacggc aaaaatcagg tggaacaaag cccccagagc    1080
ctgattattc tggagggcaa gaactgcacc ctccagtgta attacaccgt gagccctttc    1140
agcaacctga gatggtacaa gcaggatacc ggaagaggac ctgtgtctct gaccatcatg    1200
acctttagcg agaacaccaa gagcaacggc aggtatacag ccacactgga tgccgatacc    1260
aagcagtctt ctctgcacat taccgcctct cagctgtctg attctgccag ctacatctgt    1320
gtggtgtggg gaggagatac cgataagctg atctttggca caggcaccag actgcaagtg    1380
ttccctaaca tccagaaccc tgatcctgcc gtgtaccagc tgcgggacag caagagcagc    1440
gacaagagcg tgtgcctgtt caccgacttc gacagccaga ccaacgtgtc ccagagcaag    1500
gacagcgacg tgtacatcac cgataagtgc gtgctggaca tgcggagcat ggacttcaag    1560
agcaacagcg ccgtggcctg gtccaacaag agcgacttcg cctgcgccaa cgccttcaac    1620
aacagcatta tccccgagga cacattcttc ccaagccccg agagcagctg cgacgtgaag    1680
ctggtggaaa agagcttcga gacagacacc aacctgaact tccagaacct cagcgtgatc    1740
ggcttccgga tcctgctgct gaaggtggcc ggcttcaacc tgctgatgac cctgcggctg    1800
tggtccagct ga                                                        1812

<210> 188
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> codon optimized TCR number 11 construct; beta
      chain-P2A-alpha chain with cysteine substitutions
      in beta and alpha chain constant domains

<400> 188
Met Gly Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Ala
 1               5                  10                  15
Gly His Arg Asp Ala Gly Ile Thr Gln Ser Pro Arg Tyr Lys Ile Thr
            20                  25                  30
Glu Thr Gly Arg Gln Val Thr Leu Met Cys His Gln Thr Trp Ser His
        35                  40                  45
Ser Tyr Met Phe Trp Tyr Arg Gln Asp Leu Gly His Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Ala Ala Ala Asp Ile Thr Asp Lys Gly Glu Val Pro
65                  70                  75                  80
Asp Gly Tyr Val Val Ser Arg Ser Lys Thr Glu Asn Phe Pro Leu Thr
                85                  90                  95
Leu Glu Ser Ala Thr Arg Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Asp Gly Gly Gly Gln Tyr Phe Pro Gly Thr Arg Leu Thr Val Thr
        115                 120                 125
Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro
    130                 135                 140
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu
145                 150                 155                 160
Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn
                165                 170                 175
Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys
            180                 185                 190
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu
        195                 200                 205
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys
    210                 215                 220
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp
225                 230                 235                 240
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg
                245                 250                 255
Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser
            260                 265                 270
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala
        275                 280                 285
Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp
    290                 295                 300
Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala
305                 310                 315                 320
Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Lys His Leu Thr Thr
                325                 330                 335
Phe Leu Val Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly Lys Asn
            340                 345                 350
Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly Lys Asn
        355                 360                 365
Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn Leu Arg
    370                 375                 380
Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr Ile Met
385                 390                 395                 400
Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala Thr Leu
                405                 410                 415
Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser Gln Leu
            420                 425                 430
Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Trp Gly Gly Asp Thr Asp
        435                 440                 445
Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn Ile
    450                 455                 460
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
465                 470                 475                 480
Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val
                485                 490                 495
Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu
            500                 505                 510
Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser
        515                 520                 525
Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile
    530                 535                 540
Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys
545                 550                 555                 560
Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn
                565                 570                 575
Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe
            580                 585                 590
Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 189
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 11 Vbeta CDR3

<400> 189
Cys Ala Ser Ser Asp Gly Gly Gly Gln Tyr Phe
 1               5                  10

<210> 190
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR number 9 Vbeta CDR3

<400> 190
Ala Ile Leu Asp Gly Glu Gly Ser Pro Leu His
 1               5                  10
