                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
 
<120>  NANOPARTICLE-HYDROGEL COMPOSITE FOR NUCLEIC ACID MOLECULE 
       DELIVERY

<130>  4239-100294-02

<150>  US 62/628,961
<151>  2018-02-10

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-hairpin peptide sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any one of H, K, Ornithine, and R, or is not present 
       if X1 is not present

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any one of H, K, Ornithine, and R, or is not present 
       if X3 is not present

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any one of H, K, Ornithine, and R

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any one of H, K, Ornithine, and R

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any one of H, K, Ornithine, and R

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any one of H, K, Ornithine, and R

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any one of H, K, Ornithine, and R

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any one of H, K, Ornithine, and R

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any one of H, K, Ornithine, and R, or is not present 
       if X3 is not present

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present if X3 is not present

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any one of H, K, Ornithine, and R, or is not present 
       if X1 is not present

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present if X1 is not present

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Gly Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-hairpin peptide sequence

<400>  2

Val Lys Val Lys Val Lys Val Lys Val Asn Gly Thr Lys Val Lys Val 
1               5                   10                  15      


Lys Val Lys Val 
            20  


<210>  3
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  3
acauacuucu uuauaugccc au                                                22


<210>  4
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  4
uggaagacua gugauuuugu ugu                                               23


<210>  5
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  5
uacccuguag auccgaauuu gug                                               23


<210>  6
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  6
uagcagcaca uaaugguuug ug                                                22


<210>  7
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  7
uagcagcacg uaaauauugg cg                                                22


<210>  8
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  8
aucacauugc cagggauuuc c                                                 21


<210>  9
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  9
ugccuacuga gcugauauca gu                                                22


<210>  10
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  10
ugccuacuga gcugaaacac ag                                                22


<210>  11
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  11
uucaaguaau ccaggauagg cu                                                22


<210>  12
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  12
uucaaguaau ucaggauagg u                                                 21


<210>  13
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  13
agggcuuagc ugcuugugag ca                                                22


<210>  14
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  14
agagcuuagc ugauugguga ac                                                22


<210>  15
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  15
uucacagugg cuaaguucug c                                                 21


<210>  16
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  16
acugauuucu uuugguguuc ag                                                22


<210>  17
<211>  24
<212>  RNA
<213>  HOMO SAPIENS

<400>  17
gcugguuuca uauggugguu uaga                                              24


<210>  18
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  18
ugaccgauuu cuccuggugu uc                                                22


<210>  19
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  19
uguaaacauc cuacacucag cu                                                22


<210>  20
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  20
uguaaacauc cuacacucuc agc                                               23


<210>  21
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  21
gugcauugua guugcauugc a                                                 21


<210>  22
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  22
uggcaguguc uuagcugguu gu                                                22


<210>  23
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  23
ucaauaaaug ucuguugaau u                                                 21


<210>  24
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  24
uuuggcacua gcacauuuuu gcu                                               23


<210>  25
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  25
aacccguaga uccgaacuug ug                                                22


<210>  26
<211>  24
<212>  RNA
<213>  HOMO SAPIENS

<400>  26
ucccugagac ccuuuaaccu guga                                              24


<210>  27
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  27
cugaagcuca gagggcucug au                                                22


<210>  28
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  28
uucacauugu gcuacugucu gc                                                22


<210>  29
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  29
acucuuuccc uguugcacua c                                                 21


<210>  30
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  30
uaacagucua cagccauggu cg                                                22


<210>  31
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  31
uuuggucccc uucaaccagc ua                                                22


<210>  32
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  32
ugugacuggu ugaccagagg gg                                                22


<210>  33
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  33
uauggcuuuu uauuccuaug uga                                               23


<210>  34
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  34
acuccauuug uuuugaugau gga                                               23


<210>  35
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  35
ucuacagugc acgugucucc agu                                               23


<210>  36
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  36
ggugcagugc ugcaucucug gu                                                22


<210>  37
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  37
guccaguuuu cccaggaauc ccu                                               23


<210>  38
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  38
aaaguucuga gacacuccga cu                                                22


<210>  39
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  39
ucuggcuccg ugucuucacu ccc                                               23


<210>  40
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  40
aacauucaac cugucgguga gu                                                22


<210>  41
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  41
aacauucauu guugucggug ggu                                               23


<210>  42
<211>  24
<212>  RNA
<213>  HOMO SAPIENS

<400>  42
uuuggcaaug guagaacuca cacu                                              24


<210>  43
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  43
uauggcacug guagaauuca cu                                                22


<210>  44
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  44
ugauauguuu gauauauuag gu                                                22


<210>  45
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  45
ugauauguuu gauauugggu u                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  46
cugaccuaug aauugacagc c                                                 21


<210>  47
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  47
uagcagcaca gaaauauugg c                                                 21


<210>  48
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  48
uguaacagca acuccaugug ga                                                22


<210>  49
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  49
caucuuaccg gacagugcug ga                                                22


<210>  50
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  50
uggaauguaa ggaagugugu gg                                                22


<210>  51
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  51
accuuggcuc uagacugcuu acu                                               23


<210>  52
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  52
augaccuaug aauugacaga c                                                 21


<210>  53
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  53
accuggcaua caauguagau uu                                                22


<210>  54
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  54
agcuacaucu ggcuacuggg u                                                 21


<210>  55
<211>  19
<212>  RNA
<213>  HOMO SAPIENS

<400>  55
aaaagcuggg uugagagga                                                    19


<210>  56
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  56
caggucacgu cucugcaguu ac                                                22


<210>  57
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  57
uuuguucguu cggcucgcgu ga                                                22


<210>  58
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  58
aggggugcua ucugugauug a                                                 21


<210>  59
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  59
guagauucuc cuucuaugag ua                                                22


<210>  60
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  60
cguggauauu ccuucuaugu uu                                                22


<210>  61
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  61
aguggggaac ccuuccauga gg                                                22


<210>  62
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  62
cagcagcaca cugugguuug u                                                 21


<210>  63
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  63
auccuugcua ucugggugcu a                                                 21


<210>  64
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  64
uauucaggaa gguguuacuu aa                                                22


<210>  65
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  65
uacugcagac aguggcaauc a                                                 21


<210>  66
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  66
caaaacuggc aauuacuuuu gc                                                22


<210>  67
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  67
acuuguaugc uagcucaggu ag                                                22


<210>  68
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  68
guguugaaac aaucucuacu g                                                 21


<210>  69
<211>  24
<212>  RNA
<213>  HOMO SAPIENS

<400>  69
acuggcuagg gaaaaugauu ggau                                              24


<210>  70
<211>  19
<212>  RNA
<213>  HOMO SAPIENS

<400>  70
ugcgccucgg gugagcaug                                                    19


<210>  71
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  71
ucuucaaccu caggacuugc a                                                 21


<210>  72
<211>  24
<212>  RNA
<213>  HOMO SAPIENS

<400>  72
uggggagcug aggcucuggg ggug                                              24


<210>  73
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  73
aagugaucua aaggccuaca u                                                 21


<210>  74
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  74
ugcuggauca gugguucgag uc                                                22


<210>  75
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  75
uggguggucu ggagauuugu gc                                                22


<210>  76
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  76
ugugagguug gcauuguugu cu                                                22


<210>  77
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  77
cggcccgggc ugcugcuguu ccu                                               23


<210>  78
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  78
uagucccuuc cuugaagcgg uc                                                22


<210>  79
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  79
aacuccaaac acucaaaacu ca                                                22


<210>  80
<211>  20
<212>  RNA
<213>  HOMO SAPIENS

<400>  80
gaaucggaaa ggaggcgccg                                                   20


<210>  81
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  81
caguggccag agcccugcag ug                                                22


<210>  82
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  B-hairpin peptide sequence

<400>  82

Val Leu Thr Lys Val Lys Thr Lys Val Asn Gly Thr Lys Val Glu Val 
1               5                   10                  15      


Lys Val Leu Val 
            20  


<210>  83
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  83
acacacuucc uuacauucca uu                                                22


<210>  84
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  84
cugucaauuc auaggucauu u                                                 21


<210>  85
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  85
ugagguagua gguuguaugg uu                                                22


<210>  86
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  86
uaauuuuaug uauaagcuag u                                                 21


<210>  87
<211>  18
<212>  RNA
<213>  HOMO SAPIENS

<400>  87
gguggggggu guuguuuu                                                     18


<210>  88
<211>  23
<212>  RNA
<213>  HOMO SAPIENS

<400>  88
ggucuaggcc cggugagaga cuc                                               23


<210>  89
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  89
ggggcuguga uugaccagca gg                                                22


<210>  90
<211>  24
<212>  RNA
<213>  HOMO SAPIENS

<400>  90
uuaaugcuaa ucgugauagg gguu                                              24


<210>  91
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  91
uagguaguuu ccuguuguug gg                                                22


<210>  92
<211>  22
<212>  RNA
<213>  HOMO SAPIENS

<400>  92
auagcagcau gaaccugucu ca                                                22


<210>  93
<211>  21
<212>  RNA
<213>  HOMO SAPIENS

<400>  93
auagcagcau aagccugucu c                                                 21


<210>  94
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-hairpin peptide sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any amino acid, or is not present if X1 is not present

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any amino acid, or is not present if X3 is not present

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any amino acid, or is not present if X3 is not present

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present if X3 is not present

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any amino acid, or is not present if X1 is not present

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any one of F, I, L, M, T, V, W, and Y, or is not 
       present if X1 is not present

<400>  94

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Gly Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


