                         SEQUENCE LISTING

<110>  L.E.A.F. HOLDINGS GROUP LLC
       NIYIKIZA, Clet
       MOYO, Victor M.
 
<120>  GAMMA POLYGLUTAMATED ANTIFOLATES AND USES THEREOF

<130>  6155.0112

<140>  To be assigned
<141>  Herewith

<150>  US 62/627,732
<151>  2018-02-07

<150>  US 62/627,733
<151>  2018-02-07

<150>  US 62/630,613
<151>  2018-02-14

<150>  US 62/630,620
<151>  2018-02-14

<150>  US 62/630,625
<151>  2018-02-14

<150>  US 62/630,652
<151>  2018-02-14

<150>  US 62/630,751
<151>  2018-02-14

<150>  US 62/630,824
<151>  2018-02-14

<150>  US 62/636,289
<151>  2018-02-28

<150>  US 62/662,372
<151>  2018-04-25

<150>  US 62/702,774
<151>  2018-07-24

<150>  US 62/702,779
<151>  2018-07-24

<150>  US 62/764,945
<151>  2018-08-17

<150>  US 62/764,951
<151>  2018-08-17

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Arg Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  25  


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Arg Lys Lys Arg Arg Xaa Arg Arg Arg Gly Cys 
1               5                   10      


<210>  3
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3
ccgccaagaa gcg                                                          13


<210>  4
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4
gcgtgcacac gcgcgtagac ttcccccgca agtcactcgt tagcccgcca agaagcgacc       60

cctccggggc gagctgagcg gcgtggcgcg ggggcgtcat                            100


<210>  5
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
acgtgcatac gcacgtagac attccccgct tcccactcca aagtccgcca agaagcgtat       60

cccgctgagc ggcgtggcgc gggggcgtca tccgtcagct c                          101


<210>  6
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6
acttcccccg caagtcactc gttagcccgc caagaagcga cccctccggg gcgagctg         58


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Thr Pro Gln 
1               5                   10              


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
1               5                   10                  15  


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Arg Val Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Gly Leu Phe Glu Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly 
            20  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18

Arg Ser Gln Ser Arg Ser Arg Tyr Tyr Arg Gln Arg Gln Arg Ser 
1               5                   10                  15  


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19

Leu Ala Ile Pro Glu Gln Glu Tyr 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20

Leu Gly Ile Ala Glu Gln Glu Tyr 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Leu Gly Ile Pro Ala Gln Glu Tyr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Leu Gly Ile Pro Glu Ala Glu Tyr 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Leu Gly Ile Pro Glu Gln Ala Tyr 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Leu Gly Ile Ala Glu Ala Glu Tyr 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25

Leu Gly Ile Pro Glu Ala Ala Tyr 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26

Leu Gly Ile Ala Glu Gln Ala Tyr 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27

Leu Gly Ile Ala Glu Ala Ala Tyr 
1               5               


<210>  28
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
1               5                   10          


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Asp His Gln Leu Asn Pro Ala Phe 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33

Asp Pro Lys Gly Asp Pro Lys Gly 
1               5               


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34

Val Thr Val Thr Val Thr Val Thr Val Thr Gly Lys Gly Asp Pro Lys 
1               5                   10                  15      


Pro Asp 
        


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  37
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210>  44
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa can be 2 to 15 Arg independently in the L and/or D form

<400>  44

Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly Gly Gly Gly 
            20                  25                  30          


Xaa 
    


