                         SEQUENCE LISTING

<110>  National University of Singapore
 
<120>  ACTIVATING CHIMERIC RECEPTORS AND USES THEREOF IN NATURAL KILLER 
       CELL IMMUNOTHERAPY

<130>  4459.1147002 (NKT.0018WO)

<150>  62/628788
<151>  2018-02-09

<150>  62/736879
<151>  2018-09-26

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  645
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Full length NKG2D

<400>  1
gggtggattc gtggtcggag gtctcgacac agctgggaga tgagtgaatt tcataattat       60

aacttggatc tgaagaagag tgatttttca acacgatggc aaaagcaaag atgtccagta      120

gtcaaaagca aatgtagaga aaatgcatct ccattttttt tctgctgctt catcgctgta      180

gccatgggaa tccgtttcat tattatggta acaatatgga gtgctgtatt cctaaactca      240

ttattcaacc aagaagttca aattcccttg accgaaagtt actgtggccc atgtcctaaa      300

aactggatat gttacaaaaa taactgctac caattttttg atgagagtaa aaactggtat      360

gagagccagg cttcttgtat gtctcaaaat gccagccttc tgaaagtata cagcaaagag      420

gaccaggatt tacttaaact ggtgaagtca tatcattgga tgggactagt acacattcca      480

acaaatggat cttggcagtg ggaagatggc tccattctct cacccaacct actaacaata      540

attgaaatgc agaagggaga ctgtgcactc tatgcctcga gctttaaagg ctatatagaa      600

aactgttcaa ctccaaatac gtacatctgc atgcaaagga ctgtg                      645


<210>  2
<211>  405
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Truncated NKG2D

<400>  2
ttattcaacc aagaagttca aattcccttg accgaaagtt actgtggccc atgtcctaaa       60

aactggatat gttacaaaaa taactgctac caattttttg atgagagtaa aaactggtat      120

gagagccagg cttcttgtat gtctcaaaat gccagccttc tgaaagtata cagcaaagag      180

gaccaggatt tacttaaact ggtgaagtca tatcattgga tgggactagt acacattcca      240

acaaatggat cttggcagtg ggaagatggc tccattctct cacccaacct actaacaata      300

attgaaatgc agaagggaga ctgtgcactc tatgcctcga gctttaaagg ctatatagaa      360

aactgttcaa ctccaaatac gtacatctgc atgcaaagga ctgtg                      405


<210>  3
<211>  405
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Codon Optimized Truncated NKG2D

<400>  3
ctgttcaatc aggaagtcca gatccccctg acagagtctt actgcggccc atgtcccaag       60

aactggatct gctacaagaa caattgttat cagttctttg acgagagcaa gaactggtat      120

gagtcccagg cctcttgcat gagccagaat gcctctctgc tgaaggtgta cagcaaggag      180

gaccaggatc tgctgaagct ggtgaagtcc tatcactgga tgggcctggt gcacatccct      240

acaaacggct cttggcagtg ggaggacggc tccatcctgt ctccaaatct gctgaccatc      300

atcgagatgc agaagggcga ttgcgccctg tacgccagct ccttcaaggg ctatatcgag      360

aactgctcca cacccaatac ctacatctgt atgcagagga ccgtg                      405


<210>  4
<211>  63
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD8 Signaling Sequence

<400>  4
atggctctgc ccgtcaccgc actgctgctg cctctggctc tgctgctgca cgccgcacga       60

cca                                                                     63


<210>  5
<211>  135
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD8 alpha hinge

<400>  5
accacaaccc ctgcaccacg cccccctaca ccagcaccta ccatcgcaag ccagcctctg       60

tccctgcggc cagaggcatg tagaccagca gcaggaggag cagtgcacac aagaggcctg      120

gacttcgcct gcgat                                                       135


<210>  6
<211>  1722
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD8 beta

<220>
<221>  misc_feature
<222>  (674)..(773)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (859)..(958)
<223>  n is a, c, g, or t

<400>  6
atctaggtct tgctgcaccc gcacaaccta caaacagcgt cggggccttc tctgcacctc       60

cagttcccag ctcacctccc tcagtgtcac agccggttac ctttccttcc tccctggggg      120

agggcaagac ttggggcttg ctgactccag gcccagccca gcccggggca cccaggagcc      180

cctcaattgc tactcaaaca gacaagaagc ggcccgagtt agtggccagc tccaccatgc      240

actacacatc ctgacctctc tgagcctcta ctgtcactcg gggtcacaac cctttcctga      300

gcacctcccg gggcaggggg cgatgacaca catgcagctg cctgggggag gccggcggtg      360

tcccctcctt tctggaacgc ggagggtcct ggtgggctct ggaaacgcag cccagacctt      420

tgcaatgcta ggaggatgag ggcggagacc tcgcggtccc caacaccaga ctcccgcagc      480

caccgcgccc ggtcccgccc tccccactgc ccccccagct ccccgaccca ggcgccccgc      540

ccggccagct cctcacccac cccagccgcg actgtctccg ccgagccccc ggggccaggt      600

gtcccgggcg cgccacgatg cggccgcggc tgtggctcct cctggccgcg cagctgacag      660

gtaaggcggc ggcnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      720

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnttgcttt      780

cctcttccag gccggcggag gagagcccgg cttcgtttca tgaaacagta agtgtataac      840

ctgggtgtgg ccttgggann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      900

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnct      960

tgctgttgtt ttcagatttt acaaatgagc agagaatacg gttttggtgt cctgctacaa     1020

aaagacatcg gtcagtaacg agcacgatgt ggaaaaatga gagaagggac acattcaacc     1080

ctggagagtt caatggctgc tgaagctgcc tgcttttcac tgctgcaagg cctttctgtg     1140

tgtgacgtgc atgggagcaa cttgttcgtg ggtcatcggg aatactaggg agaaggtttc     1200

attgccccca gggcacttca cagagtgtgc tggaggactg agtaagaaat gctgcccatg     1260

ccaccgcttc cggctcctgt gctttccctg aactgggacc tttagtggtg gccatttagc     1320

caccatcttt gcaggttgct ttgccctggt agggcagtaa cattgggtcc tgggtctttc     1380

atggggtgat gctgggctgg ctccctgttg gtcttcccag gctggggctg accttcctcg     1440

cagagaggcc aggtgcaggt tgggaatgag gcttgctgag aggggctgtc cagttcccag     1500

aaggcatatc agtctctgag ggcttccttt ggggccggga acttgcgggt ttgaggatag     1560

gagttcactt catcttctca gctcccattt ctactcttaa gtttctcagc tcccatttct     1620

actctcccat ggcttaatgc ttctttcatt ttctgtttgt tttatacaaa tgtcttagtt     1680

gtaaaaataa agtcccaggt taaagataac aaacgggtcc tg                        1722


<210>  7
<211>  2415
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD16 alpha

<400>  7
attcttggtg ctgggtggat ccaaatccag gagatggggc aagcatcctg ggatggctga       60

gggcacactc tggcagattc tgtgtgtgtc ctcagatgct cagccacaga cctttgaggg      120

agtaaagggg gcagacccac ccaccttgcc tccaggctct ttccttcctg gtcctgttct      180

atggtggggc tcccttgcca gacttcagac tgagaagtca gatgaagttt caagaaaagg      240

aaattggtgg gtgacagaga tgggtggagg ggctggggaa aggctgttta cttcctcctg      300

tctagtcggt ttggtccctt tagggctccg gatatctttg gtgacttgtc cactccagtg      360

tggcatcatg tggcagctgc tcctcccaac tgctctgcta cttctagttt cagctggcat      420

gcggactgaa gatctcccaa aggctgtggt gttcctggag cctcaatggt acagggtgct      480

cgagaaggac agtgtgactc tgaagtgcca gggagcctac tcccctgagg acaattccac      540

acagtggttt cacaatgaga gcctcatctc aagccaggcc tcgagctact tcattgacgc      600

tgccacagtc gacgacagtg gagagtacag gtgccagaca aacctctcca ccctcagtga      660

cccggtgcag ctagaagtcc atatcggctg gctgttgctc caggcccctc ggtgggtgtt      720

caaggaggaa gaccctattc acctgaggtg tcacagctgg aagaacactg ctctgcataa      780

ggtcacatat ttacagaatg gcaaaggcag gaagtatttt catcataatt ctgacttcta      840

cattccaaaa gccacactca aagacagcgg ctcctacttc tgcagggggc tttttgggag      900

taaaaatgtg tcttcagaga ctgtgaacat caccatcact caaggtttgg cagtgtcaac      960

catctcatca ttctttccac ctgggtacca agtctctttc tgcttggtga tggtactcct     1020

ttttgcagtg gacacaggac tatatttctc tgtgaagaca aacattcgaa gctcaacaag     1080

agactggaag gaccataaat ttaaatggag aaaggaccct caagacaaat gacccccatc     1140

ccatgggggt aataagagca gtagcagcag catctctgaa catttctctg gatttgcaac     1200

cccatcatcc tcaggcctct ctacaagcag caggaaacat agaactcaga gccagatccc     1260

ttatccaact ctcgactttt ccttggtctc cagtggaagg gaaaagccca tgatcttcaa     1320

gcagggaagc cccagtgagt agctgcattc ctagaaattg aagtttcaga gctacacaaa     1380

cactttttct gtcccaaccg ttccctcaca gcaaagcaac aatacaggct agggatggta     1440

atcctttaaa catacaaaaa ttgctcgtgt tataaattac ccagtttaga ggggaaaaaa     1500

aaacaattat tcctaaataa atggataagt agaattaatg gttgaggcag gaccatacag     1560

agtgtgggaa ctgctgggga tctagggaat tcagtgggac caatgaaagc atggctgaga     1620

aatagcaggt agtccaggat agtctaaggg aggtgttccc atctgagccc agagataagg     1680

gtgtcttcct agaacattag ccgtagtgga attaacagga aatcatgagg gtgacgtaga     1740

attgagtctt ccaggggact ctatcagaac tggaccatct ccaagtatat aacgatgagt     1800

cctcttaatg ctaggagtag aaaatggtcc taggaagggg actgaggatt gcggtggggg     1860

gtggggtgga aaagaaagta cagaacaaac cctgtgtcac tgtcccaagt tgctaagtga     1920

acagaactat ctcagcatca gaatgagaaa gcctgagaag aaagaaccaa ccacaagcac     1980

acaggaagga aagcgcagga ggtgaaaatg ctttcttggc cagggtagta agaattagag     2040

gttaatgcag ggactgtaaa accacctttt ctgcttcaat atctaattcc tgtgtagctt     2100

tgttcattgc atttattaaa caaatgttgt ataaccaata ctaaatgtac tactgagctt     2160

cgctgagtta agttatgaaa ctttcaaatc cttcatcatg tcagttccaa tgaggtgggg     2220

atggagaaga caattgttgc ttatgaaaga aagctttagc tgtctctgtt ttgtaagctt     2280

taagcgcaac atttcttggt tccaataaag cattttacaa gatcttgcat gctactctta     2340

gatagaagat gggaaaacca tggtaataaa atatgaatga taaaaaaaaa aaaaaaaaaa     2400

aaaaaaaaaa aaaaa                                                      2415


<210>  8
<211>  2473
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD16 beta

<220>
<221>  misc_feature
<222>  (211)..(310)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (537)..(636)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (968)..(1067)
<223>  n is a, c, g, or t

<400>  8
aaagatgggt ggagggactg gggaaaggct gtttactccc tcctgtctag tcggcttggt       60

ccctttaggg gtccggatat ctttggtgac ttgtccactc cagtgtggca tcatgtggca      120

gctgctcctc ccaactgctc tgctacttct aggtaagtag gatctccctg gttgagggag      180

aagtttgaga tgccttgggt tcagcagaga nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      300

nnnnnnnnnn aagaggcatg aacagtggaa gaccagagag caggtagcaa ggtttccacc      360

agaaacatcc tgattcttgg gaaaattggg ctcctggggc agaggagggc aggggagttt      420

taaactcact ctatgttcta atcactctga tctctgcccc tactcaatat ttgatttact      480

cttttttctt gcagtttcag ctggcatgcg gactggtgag tcagcttcat ggtcttnnnn      540

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      600

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncact gagagctgag ctcccgggcc      660

tggggtgtct ctgtgtcttt caggctggct gttgctccag gcccctcggt gggtgttcaa      720

ggaggaagac cctattcacc tgaggtgtca cagctggaag aacactgctc tgcataaggt      780

cacatattta cagaatggca aagacaggaa gtattttcat cataattctg acttccacat      840

tccaaaagcc acactcaaag atagcggctc ctacttctgc agggggcttg ttgggagtaa      900

aaatgtgtct tcagagactg tgaacatcac catcactcaa ggtgagacat gtgccaccct      960

ggaatgcnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1020

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnttt ttcatctctc     1080

cacttctcct aataggtttg gcagtgtcaa ccatctcatc attctctcca cctgggtacc     1140

aagtctcttt ctgcttggtg atggtactcc tttttgcagt ggacacagga ctatatttct     1200

ctgtgaagac aaacatttga agctcaacaa gagactggaa ggaccataaa cttaaatgga     1260

gaaaggaccc tcaagacaaa tgacccccat cccatgggag taataagagc agtggcagca     1320

gcatctctga acatttctct ggatttgcaa ccccatcatc ctcaggcctc tctacaagca     1380

gcaggaaaca tagaactcag agccagatcc tttatccaac tctcgatttt tccttggtct     1440

ccagtggaag ggaaaagccc atgatcttca agcagggaag ccccagtgag tagctgcatt     1500

cctagaaatt gaagtttcag agctacacaa acactttttc tgtcccaacc attccctcac     1560

agtaaaacaa caatacaggc tagggatggt aatcctttaa acatacaaaa attgctcgta     1620

ttataaatta cccagtttag accggaaaaa agaaaataat tattcctaaa caaatggata     1680

agtagaatta atgattgagg caggacccta cagagtgtgg gaactgctgg ggatctagag     1740

aattcagtgg gaccaatgaa agcatggctg agaaatagca gggtagtcca ggagagtcta     1800

agggaggtgt tcccatctga gcccagagat aagggtgtct tcctagaaca ttagccgtag     1860

tggaattaac aggaaatcat gagggtgacg tagaattgag tcttccaggg gactctatca     1920

gaactggacc atttccaagt atataacgat gagccctcta atgctaggag tagcaaatgg     1980

tcctaggaag gggactgagg attggggtgg gggtggggtg gaaaagaaag tacagaacaa     2040

accctgtgtc actgtcccaa gttaagctaa gtgaacagaa ctatctcagc atcagaatga     2100

gaaagcctga gaagaaagaa ccaaccacaa gcacacagga aggaaagcgc aggaggtgaa     2160

aatgctttct tggccagggt agtaagaatt agaggttaat gcagggactg taaaaccacc     2220

ttttctgctt caatgtctag ttcctgtata gctttgttca ttgcatttat taaacaaatg     2280

ttgtataacc aatactaaat gtactactga gcttcactga gttacgctgt gaaactttca     2340

aatccttctt catgtcagtt ccaatgaggt ggggatggag aagacaattg ttgcttatga     2400

aaaaaagctt tagctgtctc tgttttgtaa gctttcagtg caacatttct tggttccaat     2460

aaagcatttt aca                                                        2473


<210>  9
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  2B4

<400>  9

Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Glu Ser 
        115                 120                 125             


Leu Leu Pro Asp Lys Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys 
    130                 135                 140                 


Ile Leu Asp Arg Gly Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser 
145                 150                 155                 160 


Arg Asp Gly Asn Val Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile 
                165                 170                 175     


Gln Thr Ala Gly Asn Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn 
            180                 185                 190         


Gly Thr His Thr Tyr Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu 
        195                 200                 205             


Ser His Thr Leu Asn Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu 
    210                 215                 220                 


Phe Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys 
                245                 250                 255     


Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu 
            260                 265                 270         


Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr 
        275                 280                 285             


Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser 
    290                 295                 300                 


Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile 
305                 310                 315                 320 


Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser 
                325                 330                 335     


Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala 
            340                 345                 350         


Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val 
        355                 360                 365             


Tyr Ser 
    370 


<210>  10
<211>  279
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  DAP10

<400>  10
atgatccatc tgggtcacat cctcttcctg cttttgctcc cagtggctgc agctcagacg       60

actccaggag agagatcatc actccctgcc ttttaccctg gcacttcagg ctcttgttcc      120

ggatgtgggt ccctctctct gccgctcctg gcaggcctcg tggctgctga tgcggtggca      180

tcgctgctca tcgtgggggc ggtgttcctg tgcgcacgcc cacgccgcag ccccgcccaa      240

gatggcaaag tctacatcaa catgccaggc aggggctga                             279


<210>  11
<211>  575
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  DAP12

<400>  11
agacttcctc cttcacttgc ctggacgctg cgccacatcc caccggccct tacactgtgg       60

tgtccagcag catccggctt catgggggga cttgaaccct gcagcaggct cctgctcctg      120

cctctcctgc tggctgtaag tgattgcagt tgctctacgg tgagcccggg cgtgctggca      180

gggatcgtga tgggagacct ggtgctgaca gtgctcattg ccctggccgt gtacttcctg      240

ggccggctgg tccctcgggg gcgaggggct gcggaggcag cgacccggaa acagcgtatc      300

actgagaccg agtcgcctta tcaggagctc cagggtcaga ggtcggatgt ctacagcgac      360

ctcaacacac agaggccgta ttacaaatga gcccgaatca tgacagtcag caacatgata      420

cctggatcca gccattcctg aagcccaccc tgcacctcat tccaactcct accgcgatac      480

agacccacag agtgccatcc ctgagagacc agaccgctcc ccaatactct cctaaaataa      540

acatgaagca caaaaacaaa aaaaaaaaaa aaaaa                                 575


<210>  12
<211>  126
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  4-1BB

<400>  12
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  13
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD3-zeta

<400>  13
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  14
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Canonical hemi-tam

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X = any amino acid

<400>  14

Asp Gly Tyr Xaa Xaa Leu 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ITSM Motif

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N = S or T

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  x = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  x = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N = L or I

<400>  15

Asn Xaa Tyr Xaa Xaa Asn 
1               5       


<210>  16
<211>  614
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Membrane-bound IL15

<400>  16
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgaactggg tgaatgtaat aagtgatttg aaaaaaattg aagatcttat tcaatctatg      120

catattgatg ctactttata tacggaaagt gatgttcacc ccagttgcaa agtaacagca      180

atgaagtgct ttctcttgga gttacaagtt atttcacttg agtccggaga tgcaagtatt      240

catgatacag tagaaaatct gatcatccta gcaaacaaca gtttgtcttc taatgggaat      300

gtaacagaat ctggatgcaa agaatgtgag gaactggagg aaaaaaatat taaagaattt      360

ttgcagagtt ttgtacatat tgtccaaatg ttcatcaaca cttctaccac gacgccagcg      420

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      480

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      540

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggtatca      600

ccctttactg ctaa                                                        614


<210>  17
<211>  204
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Membrane-bound IL15

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    130                 135                 140                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
145                 150                 155                 160 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                165                 170                 175     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            180                 185                 190         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        195                 200                 


<210>  18
<211>  1140
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NKG2D/CD8a/4-1BB/CD3z

<400>  18
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgttattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      120

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      180

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      240

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt      300

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca      360

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata      420

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtgac cacgacgcca      480

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      540

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      600

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt      660

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt      720

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa      780

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      840

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat      900

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac      960

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1020

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1080

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     1140


<210>  19
<211>  379
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence of NKG2D/CD8a/4-1BB/CD3z

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
        195                 200                 205             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    210                 215                 220                 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
225                 230                 235                 240 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                245                 250                 255     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            260                 265                 270         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        275                 280                 285             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    290                 295                 300                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
305                 310                 315                 320 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                325                 330                 335     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            340                 345                 350         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        355                 360                 365             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 


<210>  20
<211>  46
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino acid for NCR1 TM/IC

<400>  20

Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe Leu Val 
1               5                   10                  15      


Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser Arg Ala 
            20                  25                  30          


Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
        35                  40                  45      


<210>  21
<211>  276
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Full length NCR2

<400>  21

Met Ala Trp Arg Ala Leu His Pro Leu Leu Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Pro Gly Ser Gln Ala Gln Ser Lys Ala Gln Val Leu Gln Ser Val Ala 
            20                  25                  30          


Gly Gln Thr Leu Thr Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser Leu 
        35                  40                  45              


Tyr Glu Lys Lys Gly Trp Cys Lys Glu Ala Ser Ala Leu Val Cys Ile 
    50                  55                  60                  


Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg 
65                  70                  75                  80  


Phe Thr Ile Trp Asp Asp Pro Asp Ala Gly Phe Phe Thr Val Thr Met 
                85                  90                  95      


Thr Asp Leu Arg Glu Glu Asp Ser Gly His Tyr Trp Cys Arg Ile Tyr 
            100                 105                 110         


Arg Pro Ser Asp Asn Ser Val Ser Lys Ser Val Arg Phe Tyr Leu Val 
        115                 120                 125             


Val Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
    130                 135                 140                 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
145                 150                 155                 160 


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
                165                 170                 175     


Gln Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala 
            180                 185                 190         


Leu Val Pro Val Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu 
        195                 200                 205             


Ser Ala Leu Leu Val Trp Trp Gly Asp Ile Trp Trp Lys Thr Met Met 
    210                 215                 220                 


Glu Leu Arg Ser Leu Asp Thr Gln Lys Ala Thr Cys His Leu Gln Gln 
225                 230                 235                 240 


Val Thr Asp Leu Pro Trp Thr Ser Val Ser Ser Pro Val Glu Arg Glu 
                245                 250                 255     


Ile Leu Tyr His Thr Val Ala Arg Thr Lys Ile Ser Asp Asp Asp Asp 
            260                 265                 270         


Glu His Thr Leu 
        275     


<210>  22
<211>  66
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NCR3 TM/IC domains

<400>  22

Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe Tyr Ala Val Ser Phe 
1               5                   10                  15      


Leu Ser Val Ala Val Gly Ser Thr Val Tyr Tyr Gln Gly Lys Cys Leu 
            20                  25                  30          


Thr Trp Lys Gly Pro Arg Arg Gln Leu Pro Ala Val Val Pro Ala Pro 
        35                  40                  45              


Leu Pro Pro Pro Cys Gly Ser Ser Ala His Leu Leu Pro Pro Val Pro 
    50                  55                  60                  


Gly Gly 
65      


<210>  23
<211>  741
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NKG2D/CD16

<400>  23
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgcccgc       60

cccctgttca accaggaagt gcagatcccc ctgaccgagt cctattgtgg cccttgccct      120

aagaattgga tttgctataa aaacaactgc taccagttct ttgacgagtc taagaattgg      180

tatgagtccc aggcctcttg tatgagccag aacgcctctc tgctgaaggt gtacagcaag      240

gaggaccagg atctgctgaa gctggtgaag tcctatcact ggatgggcct ggtgcacatc      300

cccacaaacg gctcttggca gtgggaggac ggctccatcc tgtctcctaa tctgctgacc      360

atcatcgaga tgcagaaggg cgattgcgcc ctgtacgcca gctccttcaa gggctatatc      420

gagaactgca gcacacccaa tacctacatc tgtatgcagc ggacagtgac cacaacccca      480

gcacccaggc cccctacacc tgcaccaacc atcgcaagcc agccactgtc cctgaggcct      540

gaggcatgta ggccagcagc aggaggagca gtgcacacac ggggcctgga cttcgcctgc      600

gatgtgagct tttgtctggt catggtgctg ctgttcgccg tggataccgg cctgtatttt      660

tccgtgaaga caaatatccg gtctagcacc agagactgga aggatcacaa gttcaaatgg      720

aggaaggacc cacaggacaa g                                                741


<210>  24
<211>  247
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NKG2D/CD16

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Val Ser Phe Cys Leu Val Met 
        195                 200                 205             


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
    210                 215                 220                 


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
225                 230                 235                 240 


Arg Lys Asp Pro Gln Asp Lys 
                245         


<210>  25
<211>  870
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD8/NKG2DOpt/CD8a/CD16 TM/IC/4-1BB

<400>  25
atggctctgc ccgtcaccgc actgctgctg cctctggctc tgctgctgca cgccgcacga       60

ccactgttca atcaggaagt ccagatcccc ctgacagagt cttactgcgg cccatgtccc      120

aagaactgga tctgctacaa gaacaattgt tatcagttct ttgacgagag caagaactgg      180

tatgagtccc aggcctcttg catgagccag aatgcctctc tgctgaaggt gtacagcaag      240

gaggaccagg atctgctgaa gctggtgaag tcctatcact ggatgggcct ggtgcacatc      300

cctacaaacg gctcttggca gtgggaggac ggctccatcc tgtctccaaa tctgctgacc      360

atcatcgaga tgcagaaggg cgattgcgcc ctgtacgcca gctccttcaa gggctatatc      420

gagaactgct ccacacccaa tacctacatc tgtatgcaga ggaccgtgac cacaacccct      480

gcaccacgcc cccctacacc agcacctacc atcgcaagcc agcctctgtc cctgcggcca      540

gaggcatgta gaccagcagc aggaggagca gtgcacacaa gaggcctgga cttcgcctgc      600

gatgtgagct tttgtctggt catggtgctg ctgttcgccg tggataccgg cctgtacttt      660

tccgtgaaga caaatatcag gtctagcacc cgcgactgga aggatcacaa gtttaagtgg      720

cggaaggacc ctcaggataa gaagcggggc agaaagaagc tgctgtatat cttcaagcag      780

cccttcatgc ggcccgtgca gacaacccag gaggaagacg gctgctcatg tagatttcct      840

gaagaagaag aagggggctg tgaactgtaa                                       870


<210>  26
<211>  289
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8/NKG2DOpt/CD8a/CD16 TM/IC/4-1BB

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Val Ser Phe Cys Leu Val Met 
        195                 200                 205             


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
    210                 215                 220                 


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
225                 230                 235                 240 


Arg Lys Asp Pro Gln Asp Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                245                 250                 255     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            260                 265                 270         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        275                 280                 285             


Leu 
    


<210>  27
<211>  741
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NKG2D/NCR1

<400>  27
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgcccgc       60

cctctgttca accaggaagt gcagatccct ctgaccgaaa gctattgcgg accttgccct      120

aagaattgga tttgctataa aaacaactgc taccagttct ttgacgagtc taagaattgg      180

tatgagtctc aggccagctg tatgtcccag aacgcctctc tgctgaaggt gtacagcaag      240

gaggaccagg atctgctgaa gctggtgaag tcctatcact ggatgggcct ggtgcacatc      300

cccacaaacg gctcttggca gtgggaggac ggctctatcc tgagccctaa tctgctgacc      360

atcatcgaga tgcagaaggg cgattgcgcc ctgtacgcca gctccttcaa gggctatatc      420

gagaactgca gcacacccaa tacctacatc tgtatgcaga ggacagtgac cacaacccca      480

gcaccccgcc cccctacacc tgcaccaacc atcgcaagcc agccactgtc cctgcggcct      540

gaggcctgca gaccagcagc aggaggagca gtgcacaccc ggggcctgga cttcgcctgt      600

gatatgggcc tggcctttct ggtgctggtg gccctggtgt ggtttctggt ggaggattgg      660

ctgtcccgga agagaacaag ggagagggcc tcccgggcct ctacctggga aggaagaagg      720

agactgaaca cccagacact g                                                741


<210>  28
<211>  247
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NKG2D/NCR1

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Met Gly Leu Ala Phe Leu Val 
        195                 200                 205             


Leu Val Ala Leu Val Trp Phe Leu Val Glu Asp Trp Leu Ser Arg Lys 
    210                 215                 220                 


Arg Thr Arg Glu Arg Ala Ser Arg Ala Ser Thr Trp Glu Gly Arg Arg 
225                 230                 235                 240 


Arg Leu Asn Thr Gln Thr Leu 
                245         


<210>  29
<211>  801
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NKG2D/NCR3

<400>  29
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccaga       60

cccctgttca accaggaggt gcagattccc ctgacagaaa gctattgtgg cccttgccct      120

aaaaattgga tttgctataa aaacaactgc taccagttct ttgacgagtc taagaattgg      180

tatgagtctc aggccagctg tatgtcccag aacgcctctc tgctgaaggt gtacagcaag      240

gaggaccagg atctgctgaa gctggtgaag tcctatcact ggatgggcct ggtgcacatc      300

cctacaaacg gctcttggca gtgggaggac ggctctatcc tgagcccaaa tctgctgacc      360

atcatcgaga tgcagaaggg cgattgcgcc ctgtacgcca gctccttcaa gggctatatc      420

gagaactgca gcacacccaa tacctacatc tgtatgcagc ggacagtgac cacaacccca      480

gcacccagac cccctacacc tgcaccaacc atcgccagcc agccactgtc cctgaggccc      540

gaggcatgca ggcctgcagc aggaggcgcc gtgcacacaa ggggcctgga ctttgcctgt      600

gatgcaggaa ccgtgctgct gctgagagca ggcttctatg ccgtgtcctt tctgtctgtg      660

gccgtgggct ccacagtgta ctatcagggc aagtgcctga cctggaaggg cccacggaga      720

cagctgcccg ccgtggtgcc cgcccctctg ccaccccctt gtggcagtag cgcccacctg      780

ctgccacccg tgcccggagg a                                                801


<210>  30
<211>  267
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NKG2D/NCR3

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            20                  25                  30          


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        35                  40                  45              


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    50                  55                  60                  


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
65                  70                  75                  80  


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                85                  90                  95      


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            100                 105                 110         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        115                 120                 125             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    130                 135                 140                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Thr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                165                 170                 175     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            180                 185                 190         


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ala Gly Thr Val Leu Leu Leu 
        195                 200                 205             


Arg Ala Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser 
    210                 215                 220                 


Thr Val Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg 
225                 230                 235                 240 


Gln Leu Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser 
                245                 250                 255     


Ser Ala His Leu Leu Pro Pro Val Pro Gly Gly 
            260                 265         


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N is an integer indicating the number of GGGGS repeated

<400>  31

Gly Gly Gly Gly Ser Asn 
1               5       


<210>  32
<211>  60
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GS3/CD8a

<400>  32

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
1               5                   10                  15      


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            20                  25                  30          


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        35                  40                  45              


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    50                  55                  60  


<210>  33
<211>  45
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GS9

<400>  33

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GS3

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  2B4 ICR

<400>  35

Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210>  36
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  2B4 ICR

<400>  36
tggaggagga aaaggaagga gaaacagagc gagacctccc ctaaggagtt cctgaccatc       60

tacgaggacg tgaaggacct gaagaccagg aggaaccacg agcaggaaca gacctttcct      120

ggcggaggca gcaccatcta cagcatgatc cagagccaga gcagcgcccc taccagccaa      180

gagcctgcct acaccctgta cagcctgatc cagcccagca ggaaaagcgg ctccaggaag      240

aggaaccaca gccccagctt caacagcacc atctatgagg tgatcggcaa gagccagccc      300

aaggcccaga accctgccag gctgtccagg aaggagctgg agaacttcga cgtgtacagc      360


<210>  37
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NKp80 ICR

<400>  37

Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys 
        35              


<210>  38
<211>  114
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NKp80 ICR

<400>  38
atgcaggatg aggacggcta tatgaccctg aacgtccagt ccaagaagag gtccagcgct       60

cagaccagcc agctgacctt caaggactac tccgtgaccc tgcactggta caag            114


<210>  39
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  B2Ad N-term ECD

<400>  39

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu 
            20                  25                  30  


<210>  40
<211>  90
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  B2 AdR N-term ECD

<400>  40
atggggcaac ccgggaacgg cagcgccttc ttgctggcac ccaatagaag ccatgcgccg       60

gaccacgacg tcacgcagca aagggacgag                                        90


<210>  41
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  B2 AdR TM helix

<400>  41

Val Trp Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala 
1               5                   10                  15      


Ile Val Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu 
            20                  25                  30          


Arg 
    


<210>  42
<211>  99
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  B2AdR TM helix

<400>  42
gtgtgggtgg tgggcatggg catcgtcatg tctctcatcg tcctggccat cgtgtttggc       60

aatgtgctgg tcatcacagc cattgccaag ttcgagcgt                              99


<210>  43
<211>  924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_1

<400>  43
gccgccacca tggctctgcc cgtcaccgca ctgctgctgc ctctggctct gctgctgcac       60

gccgcacgac cactgttcaa tcaggaagtc cagatccccc tgacagagtc ttactgcggc      120

ccatgtccca agaactggat ctgctacaag aacaattgtt atcagttctt tgacgagagc      180

aagaactggt atgagtccca ggcctcttgc atgagccaga atgcctctct gctgaaggtg      240

tacagcaagg aggaccagga tctgctgaag ctggtgaagt cctatcactg gatgggcctg      300

gtgcacatcc ctacaaacgg ctcttggcag tgggaggacg gctccatcct gtctccaaat      360

ctgctgacca tcatcgagat gcagaagggc gattgcgccc tgtacgccag ctccttcaag      420

ggctatatcg agaactgctc cacacccaat acctacatct gtatgcagag gaccgtgggt      480

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctaccacaac ccctgcacca      540

cgccccccta caccagcacc taccatcgca agccagcctc tgtccctgcg gccagaggca      600

tgtagaccag cagcaggagg agcagtgcac acaagaggcc tggacttcgc ctgcgatgtg      660

agcttttgtc tggtcatggt gctgctgttc gccgtggata ccggcctgta cttttccgtg      720

aagacaaata tcaggtctag cacccgcgac tggaaggatc acaagtttaa gtggcggaag      780

gaccctcagg ataagaagcg gggcagaaag aagctgctgt atatcttcaa gcagcccttc      840

atgcggcccg tgcagacaac ccaggaggaa gacggctgct catgtagatt tcctgaagaa      900

gaagaagggg gctgtgaact gtaa                                             924


<210>  44
<211>  789
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_2

<400>  44
gccgccacca tggctctgcc cgtcaccgca ctgctgctgc ctctggctct gctgctgcac       60

gccgcacgac cactgttcaa tcaggaagtc cagatccccc tgacagagtc ttactgcggc      120

ccatgtccca agaactggat ctgctacaag aacaattgtt atcagttctt tgacgagagc      180

aagaactggt atgagtccca ggcctcttgc atgagccaga atgcctctct gctgaaggtg      240

tacagcaagg aggaccagga tctgctgaag ctggtgaagt cctatcactg gatgggcctg      300

gtgcacatcc ctacaaacgg ctcttggcag tgggaggacg gctccatcct gtctccaaat      360

ctgctgacca tcatcgagat gcagaagggc gattgcgccc tgtacgccag ctccttcaag      420

ggctatatcg agaactgctc cacacccaat acctacatct gtatgcagag gaccgtgggt      480

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctgtgagctt ttgtctggtc      540

atggtgctgc tgttcgccgt ggataccggc ctgtactttt ccgtgaagac aaatatcagg      600

tctagcaccc gcgactggaa ggatcacaag tttaagtggc ggaaggaccc tcaggataag      660

aagcggggca gaaagaagct gctgtatatc ttcaagcagc ccttcatgcg gcccgtgcag      720

acaacccagg aggaagacgg ctgctcatgt agatttcctg aagaagaaga agggggctgt      780

gaactgtaa                                                              789


<210>  45
<211>  744
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_3

<400>  45
gccgccacca tggctctgcc cgtcaccgca ctgctgctgc ctctggctct gctgctgcac       60

gccgcacgac cactgttcaa tcaggaagtc cagatccccc tgacagagtc ttactgcggc      120

ccatgtccca agaactggat ctgctacaag aacaattgtt atcagttctt tgacgagagc      180

aagaactggt atgagtccca ggcctcttgc atgagccaga atgcctctct gctgaaggtg      240

tacagcaagg aggaccagga tctgctgaag ctggtgaagt cctatcactg gatgggcctg      300

gtgcacatcc ctacaaacgg ctcttggcag tgggaggacg gctccatcct gtctccaaat      360

ctgctgacca tcatcgagat gcagaagggc gattgcgccc tgtacgccag ctccttcaag      420

ggctatatcg agaactgctc cacacccaat acctacatct gtatgcagag gaccgtggtg      480

agcttttgtc tggtcatggt gctgctgttc gccgtggata ccggcctgta cttttccgtg      540

aagacaaata tcaggtctag cacccgcgac tggaaggatc acaagtttaa gtggcggaag      600

gaccctcagg ataagaagcg gggcagaaag aagctgctgt atatcttcaa gcagcccttc      660

atgcggcccg tgcagacaac ccaggaggaa gacggctgct catgtagatt tcctgaagaa      720

gaagaagggg gctgtgaact gtaa                                             744


<210>  46
<211>  1164
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_4

<400>  46
gccgccacca tggccctgcc tgtgacagcc ctgctgctgc ctctggctct gctgctgcac       60

gctgccagac ccttattcaa ccaagaagtt caaattccct tgaccgaaag ttactgtggc      120

ccatgtccta aaaactggat atgttacaaa aataactgct accaattttt tgatgagagt      180

aaaaactggt atgagagcca ggcttcttgt atgtctcaaa atgccagcct tctgaaagta      240

tacagcaaag aggaccagga tttacttaaa ctggtgaagt catatcattg gatgggacta      300

gtacacattc caacaaatgg atcttggcag tgggaagatg gctccattct ctcacccaac      360

ctactaacaa taattgaaat gcagaaggga gactgtgcac tctatgcctc gagctttaaa      420

ggctatatag aaaactgttc aactccaaat acgtacatct gcatgcaaag gactgtgacc      480

acaacccccg ctcccagacc tcctacccct gcccctacaa tcgccagcca gcccctgagc      540

ctgagacccg aagcctgtag acctgctgcc ggaggcgctg tgcacacaag aggcctggac      600

ttcgcctgcg atatctatat ctgggcccct ctggctggaa cctgtggcgt gctgctgctg      660

agcctggtga ttaccaagag gggcaggaag aagctgctgt acatcttcaa gcagcctttc      720

atgaggcccg tgcaaaccac ccaggaggag gacggctgca gctgcagatt ccctgaggag      780

gaggagggcg gatgcgagct gtggaggagg aaaaggaagg agaaacagag cgagacctcc      840

cctaaggagt tcctgaccat ctacgaggac gtgaaggacc tgaagaccag gaggaaccac      900

gagcaggaac agacctttcc tggcggaggc agcaccatct acagcatgat ccagagccag      960

agcagcgccc ctaccagcca agagcctgcc tacaccctgt acagcctgat ccagcccagc     1020

aggaaaagcg gctccaggaa gaggaaccac agccccagct tcaacagcac catctatgag     1080

gtgatcggca agagccagcc caaggcccag aaccctgcca ggctgtccag gaaggagctg     1140

gagaacttcg acgtgtacag ctga                                            1164


<210>  47
<211>  1155
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_5

<400>  47
gccgccacca tggccctgcc tgtgacagcc ctgctgctgc ctctggctct gctgctgcac       60

gctgccagac ccttattcaa ccaagaagtt caaattccct tgaccgaaag ttactgtggc      120

ccatgtccta aaaactggat atgttacaaa aataactgct accaattttt tgatgagagt      180

aaaaactggt atgagagcca ggcttcttgt atgtctcaaa atgccagcct tctgaaagta      240

tacagcaaag aggaccagga tttacttaaa ctggtgaagt catatcattg gatgggacta      300

gtacacattc caacaaatgg atcttggcag tgggaagatg gctccattct ctcacccaac      360

ctactaacaa taattgaaat gcagaaggga gactgtgcac tctatgcctc gagctttaaa      420

ggctatatag aaaactgttc aactccaaat acgtacatct gcatgcaaag gactgtgatg      480

ggacagcctg gaaacggcag cgccttcctg ctggccccta acagaagcca cgcccccgat      540

cacgatgtga cccagcagag ggacgaggtg tgggtggtgg gcatgggcat cgtgatgagc      600

ctgatcgtgc tggctatcgt gttcggcaac gtgctggtga tcaccgccat cgccaagttc      660

gagaggaaga ggggcaggaa aaagctgctc tacatcttca agcagccctt catgaggccc      720

gtgcagacca cccaggaaga ggatggctgc tcctgtaggt ttcccgagga ggaggagggc      780

ggctgtgagc tgtggaggag aaaaaggaag gagaagcaga gcgagaccag ccccaaggag      840

ttcctgacca tctacgagga cgtgaaggac ctgaagacca ggaggaacca cgagcaggaa      900

cagaccttcc ccggcggagg cagcaccatc tacagcatga tccagagcca gtccagcgcc      960

cccacaagcc aggaacccgc ctacacactg tatagcctga tccagccctc caggaagagc     1020

ggcagcagga agaggaacca cagccccagc ttcaacagca ccatttacga ggtgatcgga     1080

aagagccagc ccaaggctca gaaccccgcc aggctgagca ggaaggagct cgaaaacttc     1140

gacgtgtaca gctga                                                      1155


<210>  48
<211>  1349
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_6

<400>  48
ggatccgaat tcgccgccac catggccctg cctgtgacag ccctgctgct gcctctggct       60

ctgctgctgc acgctgccag acccttattc aaccaagaag ttcaaattcc cttgaccgaa      120

agttactgtg gcccatgtcc taaaaactgg atatgttaca aaaataactg ctaccaattt      180

tttgatgaga gtaaaaactg gtatgagagc caggcttctt gtatgtctca aaatgccagc      240

cttctgaaag tatacagcaa agaggaccag gatttactta aactggtgaa gtcatatcat      300

tggatgggac tagtacacat tccaacaaat ggatcttggc agtgggaaga tggctccatt      360

ctctcaccca acctactaac aataattgaa atgcagaagg gagactgtgc actctatgcc      420

tcgagcttta aaggctatat agaaaactgt tcaactccaa atacgtacat ctgcatgcaa      480

aggactgtga ccacaacccc tgctcccaga cctcccacac ccgcccctac aatcgcctcc      540

cagcctctga gcctgagacc cgaagcctgt agacctgccg ccggcggagc tgtgcataca      600

agaggcctgg acttcgcctg cgacatctac atctgggccc ctctggctgg cacatgcgga      660

gtcctgctgc tgagcctggt gatcaccaag aggggcagga agaagctgct gtacatcttc      720

aagcagccct tcatgaggcc tgtgcagacc acacaggagg aggacggctg ctcctgcagg      780

ttccctgagg aggaggaggg aggctgcgag ctgtggagga ggaagagaaa ggagaagcag      840

tccgagacct cccccaagga gttcctcacc atttacgagg acgtgaagga cctgaagacc      900

aggagaaacc acgagcagga acaaaccttc cccggcggcg gcagcaccat ctacagcatg      960

atccagagcc agtcctccgc ccctacaagc caggagcctg cctacaccct gtacagcctg     1020

atccagccta gcaggaagag cggctccagg aagaggaacc actcccccag cttcaacagc     1080

accatttatg aggtgatcgg caagtcccag cccaaggccc agaaccctgc cagactgtcc     1140

aggaaggagc tggagaactt cgacgtctac tccggcggcg gcggcagcgg cggaggaggc     1200

tccggaggag gcggcagcat gcaggatgag gacggctata tgaccctgaa cgtccagtcc     1260

aagaagaggt ccagcgctca gaccagccag ctgaccttca aggactactc cgtgaccctg     1320

cactggtaca agtgagcggc cgcgtcgac                                       1349


<210>  49
<211>  989
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_7

<400>  49
ggatccgaat tcgccgccac catggccctg cctgtgacag ccctgctgct gcctctggct       60

ctgctgctgc atgccgccag acccttattc aaccaagaag ttcaaattcc cttgaccgaa      120

agttactgtg gcccatgtcc taaaaactgg atatgttaca aaaataactg ctaccaattt      180

tttgatgaga gtaaaaactg gtatgagagc caggcttctt gtatgtctca aaatgccagc      240

cttctgaaag tatacagcaa agaggaccag gatttactta aactggtgaa gtcatatcat      300

tggatgggac tagtacacat tccaacaaat ggatcttggc agtgggaaga tggctccatt      360

ctctcaccca acctactaac aataattgaa atgcagaagg gagactgtgc actctatgcc      420

tcgagcttta aaggctatat agaaaactgt tcaactccaa atacgtacat ctgcatgcaa      480

aggactgtga ccaccacccc tgctcccaga ccccctacac ctgcccctac aatcgccagc      540

cagcccctga gcctgagacc tgaggcctgc agacctgctg ctggaggcgc tgtgcacaca      600

aggggcctcg acttcgcctg cgacatctac atctgggccc ctctggccgg cacatgtgga      660

gtgctgctgc tgtccctggt gatcaccaag aggggcagga agaagctgct gtacatcttc      720

aagcagccct tcatgaggcc cgtgcagacc acccaggagg aggacggctg ctcctgcaga      780

ttccccgagg aggaggaggg cggatgtgaa ctgggcggag gaggcagcgg cggcggcggc      840

agcggcggcg gcggcagcat gcaggatgag gacggctaca tgaccctgaa cgtgcagagc      900

aagaagagga gcagcgccca gaccagccag ctgaccttca aggactacag cgtgaccctg      960

cactggtaca agtgagcggc cgcgtcgac                                        989


<210>  50
<211>  1430
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_8

<400>  50
ggatccgaat tcgccgccac catggccctg cccgtgacag ctctgctgct gcctctggcc       60

ctgctgctgc atgccgctag acccctgttc aaccaggagg tgcagatccc cctgaccgaa      120

agctactgcg gcccctgccc caagaactgg atctgttaca agaacaactg ctatcagttc      180

ttcgacgaga gcaagaactg gtacgagagc caggccagct gtatgagcca gaacgccagc      240

ctgctgaaag tgtatagcaa ggaggaccag gacctgctga agctggtgaa gagctaccac      300

tggatgggcc tggtgcacat ccccaccaac ggaagctggc agtgggagga cggcagcatc      360

ctgagcccca acctgctgac catcatcgag atgcagaagg gcgactgcgc cctgtatgcc      420

agcagcttca agggctacat cgagaactgt agcaccccca acacctacat ctgcatgcag      480

aggaccgtgg gcggcggcgg cagcggcgga ggcggctccg gcggcggcgg cagcttattc      540

aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg      600

atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc      660

caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag      720

gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat      780

ggatcttggc agtgggaaga tggctccatt ctctcaccca acctactaac aataattgaa      840

atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt      900

tcaactccaa atacgtacat ctgcatgcaa aggactgtga tgggccagcc tggcaacggc      960

agcgcctttc tgctggcccc caacaggagc catgcccctg accacgacgt gacccagcag     1020

agggacgagg tgtgggtggt gggcatgggc atcgtgatga gcctgatcgt gctggccatc     1080

gtgttcggca acgtgctggt gatcaccgcc atcgccaagt tcgagaggaa gaggggcagg     1140

aagaagctgc tgtacatctt caagcagccc ttcatgagac ccgtgcaaac cacccaggag     1200

gaggacggct gcagctgcag gtttcccgag gaggaggagg gcggatgcga actgggaggc     1260

ggaggaagcg gaggaggagg atccggagga ggcggaagca tgcaggacga ggacggctac     1320

atgaccctga acgtccagag caagaagagg agcagcgccc agacctccca gctgaccttc     1380

aaggactact ccgtgaccct gcactggtac aagtgagcgg ccgcgtcgac                1430


<210>  51
<211>  1439
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_9

<400>  51
ggatccgaat tcgccgccac catggccctg cccgtgacag ctctgctgct gcctctggcc       60

ctgctgctgc atgccgctag acccctgttc aaccaggagg tgcagatccc cctgaccgaa      120

agctactgcg gcccctgccc caagaactgg atctgttaca agaacaactg ctatcagttc      180

ttcgacgaga gcaagaactg gtacgagagc caggccagct gtatgagcca gaacgccagc      240

ctgctgaaag tgtatagcaa ggaggaccag gacctgctga agctggtgaa gagctaccac      300

tggatgggcc tggtgcacat ccccaccaac ggaagctggc agtgggagga cggcagcatc      360

ctgagcccca acctgctgac catcatcgag atgcagaagg gcgactgcgc cctgtatgcc      420

agcagcttca agggctacat cgagaactgt agcaccccca acacctacat ctgcatgcag      480

aggaccgtgg gcggcggcgg cagcggcgga ggcggctccg gcggcggcgg cagcttattc      540

aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg      600

atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc      660

caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag      720

gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat      780

ggatcttggc agtgggaaga tggctccatt ctctcaccca acctactaac aataattgaa      840

atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt      900

tcaactccaa atacgtacat ctgcatgcaa aggactgtga ccaccacccc tgctcccaga      960

ccccctacac ctgcccctac aatcgccagc cagcccctga gcctgagacc tgaggcctgc     1020

agacctgctg ctggaggcgc tgtgcacaca aggggcctcg acttcgcctg cgacatctac     1080

atctgggccc ctctggccgg cacatgtgga gtgctgctgc tgtccctggt gatcaccaag     1140

aggggcagga agaagctgct gtacatcttc aagcagccct tcatgaggcc cgtgcagacc     1200

acccaggagg aggacggctg ctcctgcaga ttccccgagg aggaggaggg cggatgtgaa     1260

ctgggcggag gaggcagcgg cggcggcggc agcggcggcg gcggcagcat gcaggatgag     1320

gacggctaca tgaccctgaa cgtgcagagc aagaagagga gcagcgccca gaccagccag     1380

ctgaccttca aggactacag cgtgaccctg cactggtaca agtgagcggc cgcgtcgac      1439


<210>  52
<211>  1329
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_10

<400>  52
gccgccacaa tggccctgcc tgtgacagcc ctgctgctgc ctctggccct gctgctgcat       60

gctgccaggc ctctgttcaa ccaggaggtg cagatccctc tgaccgagag ctactgcggc      120

ccctgcccca agaactggat ctgctacaag aacaactgct accagttctt cgacgagagc      180

aagaactggt acgagagcca ggccagctgc atgtcccaga acgctagcct gctgaaggtg      240

tatagcaagg aggaccagga cctgctgaag ctggtgaaga gctaccactg gatgggcctg      300

gtgcacatcc ccaccaacgg ctcctggcag tgggaggacg gcagcatcct gagccctaac      360

ctgctgacca tcatcgagat gcagaaggga gactgcgccc tgtacgccag ctcctttaag      420

ggctacatcg agaactgcag cacccccaac acctacatct gtatgcagag gaccgtggga      480

ggcggcggca gcggcggcgg cggcagcggc ggcggcggca gcttattcaa ccaagaagtt      540

caaattccct tgaccgaaag ttactgtggc ccatgtccta aaaactggat atgttacaaa      600

aataactgct accaattttt tgatgagagt aaaaactggt atgagagcca ggcttcttgt      660

atgtctcaaa atgccagcct tctgaaagta tacagcaaag aggaccagga tttacttaaa      720

ctggtgaagt catatcattg gatgggacta gtacacattc caacaaatgg atcttggcag      780

tgggaagatg gctccattct ctcacccaac ctactaacaa taattgaaat gcagaaggga      840

gactgtgcac tctatgcctc gagctttaaa ggctatatag aaaactgttc aactccaaat      900

acgtacatct gcatgcaaag gactgtgacc accacccctg cccctagacc ccctacacct      960

gcccctacca tcgccagcca gcctctgagc ctgagacccg aggcctgtag acctgctgcc     1020

ggaggagccg tgcacacaag aggcctggac ttcgcctgcg acgtgagctt ctgcctggtg     1080

atggtgctgc tgttcgccgt ggacaccggc ctgtacttca gcgtgaagac caacatcagg     1140

agcagcacca gggactggaa ggaccacaaa ttcaagtgga ggaaggaccc ccaggacaag     1200

aagaggggca ggaagaagct gctgtacatc ttcaagcagc ccttcatgag gcctgtgcag     1260

accacccagg aggaggacgg ctgcagctgc aggttccctg aggaggaaga gggcggctgc     1320

gagctgtga                                                             1329


<210>  53
<211>  1239
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_11

<400>  53
gccgccacca tggctctgcc cgtcaccgca ctgctgctgc ctctggctct gctgctgcac       60

gccgcacgac cactgttcaa tcaggaagtc cagatccccc tgacagagtc ttactgcggc      120

ccatgtccca agaactggat ctgctacaag aacaattgtt atcagttctt tgacgagagc      180

aagaactggt atgagtccca ggcctcttgc atgagccaga atgcctctct gctgaaggtg      240

tacagcaagg aggaccagga tctgctgaag ctggtgaagt cctatcactg gatgggcctg      300

gtgcacatcc ctacaaacgg ctcttggcag tgggaggacg gctccatcct gtctccaaat      360

ctgctgacca tcatcgagat gcagaagggc gattgcgccc tgtacgccag ctccttcaag      420

ggctatatcg agaactgctc cacacccaat acctacatct gtatgcagag gaccgtgacc      480

acaacccctg caccacgccc ccctacacca gcacctacca tcgcaagcca gcctctgtcc      540

ctgcggccag aggcatgtag accagcagca ggaggagcag tgcacacaag aggcctggac      600

ttcgcctgcg atgtgagctt ttgtctggtc atggtgctgc tgttcgccgt ggataccggc      660

ctgtactttt ccgtgaagac aaatatcagg tctagcaccc gcgactggaa ggatcacaag      720

tttaagtggc ggaaggaccc tcaggataag aagcggggca gaaagaagct gctgtatatc      780

ttcaagcagc ccttcatgcg gcccgtgcag acaacccagg aggaagacgg ctgctcatgt      840

agatttcctg aagaagaaga agggggctgt gaactgtgga ggaggaaaag gaaggagaaa      900

cagagcgaga cctcccctaa ggagttcctg accatctacg aggacgtgaa ggacctgaag      960

accaggagga accacgagca ggaacagacc tttcctggcg gaggcagcac catctacagc     1020

atgatccaga gccagagcag cgcccctacc agccaagagc ctgcctacac cctgtacagc     1080

ctgatccagc ccagcaggaa aagcggctcc aggaagagga accacagccc cagcttcaac     1140

agcaccatct atgaggtgat cggcaagagc cagcccaagg cccagaaccc tgccaggctg     1200

tccaggaagg agctggagaa cttcgacgtg tacagctga                            1239


<210>  54
<211>  1064
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  NK15_12

<400>  54
ggatccgaat tcgccgccac catggctctg cccgtcaccg cactgctgct gcctctggct       60

ctgctgctgc acgccgcacg accactgttc aatcaggaag tccagatccc cctgacagag      120

tcttactgcg gcccatgtcc caagaactgg atctgctaca agaacaattg ttatcagttc      180

tttgacgaga gcaagaactg gtatgagtcc caggcctctt gcatgagcca gaatgcctct      240

ctgctgaagg tgtacagcaa ggaggaccag gatctgctga agctggtgaa gtcctatcac      300

tggatgggcc tggtgcacat ccctacaaac ggctcttggc agtgggagga cggctccatc      360

ctgtctccaa atctgctgac catcatcgag atgcagaagg gcgattgcgc cctgtacgcc      420

agctccttca agggctatat cgagaactgc tccacaccca atacctacat ctgtatgcag      480

aggaccgtga ccacaacccc tgcaccacgc ccccctacac cagcacctac catcgcaagc      540

cagcctctgt ccctgcggcc agaggcatgt agaccagcag caggaggagc agtgcacaca      600

agaggcctgg acttcgcctg cgatgtgagc ttttgtctgg tcatggtgct gctgttcgcc      660

gtggataccg gcctgtactt ttccgtgaag acaaatatca ggtctagcac ccgcgactgg      720

aaggatcaca agtttaagtg gcggaaggac cctcaggata agaagcgggg cagaaagaag      780

ctgctgtata tcttcaagca gcccttcatg cggcccgtgc agacaaccca ggaggaagac      840

ggctgctcat gtagatttcc tgaagaagaa gaagggggct gtgaactggg cggaggaggc      900

agcggcggcg gcggcagcgg cggcggcggc agcatgcagg atgaggacgg ctacatgacc      960

ctgaacgtgc agagcaagaa gaggagcagc gcccagacca gccagctgac cttcaaggac     1020

tacagcgtga ccctgcactg gtacaagtga gcggccgcgt cgac                      1064


<210>  55
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  FLAG tag

<400>  55

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  His tag

<400>  56

His His His His His His 
1               5       


<210>  57
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Myc tag

<400>  57

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  58
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino Acid NKG2C high affinity modification

<400>  58

Ser Ile Ile Ser 
1               


<210>  59
<211>  1137
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  DNA Sequence Chimeric CD94-CD8a TM-4-1BB/CD3zeta

<400>  59
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgccaggac ccaacataga actccagaaa gactctgact gctgttcttg ccaagaaaaa      120

tgggttgggt accggtgcaa ctgttacttc atttccagtg aacagaaaac ttggaacgaa      180

agtcggcatc tctgtgcttc tcagaaatcc agcctgcttc agcttcaaaa cacagatgaa      240

ctggatttta tgagctccag tcaacaattt tactggattg gactctctta cagtgaggag      300

cacaccgcct ggttgtggga gaatggctct gcactctccc agtatctatt tccatcattt      360

gaaactttta atacaaagaa ctgcatagcg tataatccaa atggaaatgc tttagatgaa      420

tcctgtgaag ataaaaatcg ttatatctgt aagcaacagc tcattaccac gacgccagcg      480

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      540

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      600

atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc      660

accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg      720

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa      780

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag      840

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt      900

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct      960

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1020

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1080

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa        1137


<210>  60
<211>  378
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino Acid Sequence Chimeric CD94-CD8a TM-4-1BB/CD3zeta

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
            20                  25                  30          


Asp Cys Cys Ser Cys Gln Glu Lys Trp Val Gly Tyr Arg Cys Asn Cys 
        35                  40                  45              


Tyr Phe Ile Ser Ser Glu Gln Lys Thr Trp Asn Glu Ser Arg His Leu 
    50                  55                  60                  


Cys Ala Ser Gln Lys Ser Ser Leu Leu Gln Leu Gln Asn Thr Asp Glu 
65                  70                  75                  80  


Leu Asp Phe Met Ser Ser Ser Gln Gln Phe Tyr Trp Ile Gly Leu Ser 
                85                  90                  95      


Tyr Ser Glu Glu His Thr Ala Trp Leu Trp Glu Asn Gly Ser Ala Leu 
            100                 105                 110         


Ser Gln Tyr Leu Phe Pro Ser Phe Glu Thr Phe Asn Thr Lys Asn Cys 
        115                 120                 125             


Ile Ala Tyr Asn Pro Asn Gly Asn Ala Leu Asp Glu Ser Cys Glu Asp 
    130                 135                 140                 


Lys Asn Arg Tyr Ile Cys Lys Gln Gln Leu Ile Thr Thr Thr Pro Ala 
145                 150                 155                 160 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
                165                 170                 175     


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
            180                 185                 190         


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
        195                 200                 205             


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
    210                 215                 220                 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
225                 230                 235                 240 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
                245                 250                 255     


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
            260                 265                 270         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        275                 280                 285             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    290                 295                 300                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
305                 310                 315                 320 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                325                 330                 335     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            340                 345                 350         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        355                 360                 365             


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375             


<210>  61
<211>  1119
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  DNA Sequence chimeric NKG2A Receptor - CD8a TM-4-1BB/CD3zeta

<400>  61
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgctgaata caagaactca gaaagcacgt cattgtggcc attgtcctga ggagtggatt      120

acatattcca acagttgtta ctacattggt aaggaaagaa gaacttggga agagagtttg      180

ctggcctgta cttcgaagaa ctccagtctg ctttctatag ataatgaaga agaaatgaaa      240

tttctgtcca tcatttcacc atcctcatgg attggtgtgt ttcgtaacag cagtcatcat      300

ccatgggtga caatgaatgg tttggctttc aaacatgaga taaaagactc agataatgct      360

gaacttaact gtgcagtgct acaagtaaat cgacttaaat cagcccagtg tggatcttca      420

ataatatatc attgtaagca taagcttacc acgacgccag cgccgcgacc accaacaccg      480

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      540

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      600

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg      660

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact      720

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg      780

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      840

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      900

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      960

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1020

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1080

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                            1119


<210>  62
<211>  372
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino Acid Sequence chimeric NKG2A Receptor - CD8a 
       TM-4-1BB/CD3zeta

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys 
            20                  25                  30          


Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys Tyr Tyr 
        35                  40                  45              


Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala Cys Thr 
    50                  55                  60                  


Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu Met Lys 
65                  70                  75                  80  


Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly Val Phe Arg Asn 
                85                  90                  95      


Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu Ala Phe Lys His 
            100                 105                 110         


Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val Leu Gln 
        115                 120                 125             


Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Ile Ile Tyr His 
    130                 135                 140                 


Cys Lys His Lys Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg 
    370         


<210>  63
<211>  690
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  DNA Sequence Engineered NKG2C

<400>  63
aataaacaaa gaggaacctt ctcagaagtg agtctggccc aggacccaaa gcggcagcaa       60

aggaaaccta aaggcaataa aagctccatt tcaggaaccg aacaggaaat attccaagta      120

gaattaaatc ttcaaaatcc ttccctgaat catcaaggga ttgataaaat atatgactgc      180

caaggtttac tgccacctcc agagaagctc actgccgagg tcctaggaat catttgcatt      240

gtcctgatgg ccactgtgtt aaaaacaata gttcttattc ctttcctgga gcagaacaat      300

ttttccccga atacaagaac gcagaaagca cgtcattgtg gccattgtcc tgaggagtgg      360

attacatatt ccaacagttg ttattacatt ggtaaggaaa gaagaacttg ggaagagagt      420

ttgctggcct gtacttcgaa gaactccagt ctgctttcta tagataatga agaagaaatg      480

aaatttctgt ccatcatttc accttcctca tggattggtg tgtttcgtaa cagcagtcat      540

catccatggg tgacaataaa tggtttggct ttcaaacata agataaaaga ctcagataat      600

gctgaactta actgtgcagt gctacaagta aatcgactta aatcagccca gtgtggatct      660

tcaatgatat atcattgtaa gcataagctt                                       690


<210>  64
<211>  231
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence engineered NKG2C

<400>  64

Met Asn Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Phe Ser Pro Asn Thr Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
    130                 135                 140                 


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
145                 150                 155                 160 


Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly Val Phe 
                165                 170                 175     


Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala Phe 
            180                 185                 190         


Lys His Lys Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
        195                 200                 205             


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Met Ile 
    210                 215                 220                 


Tyr His Cys Lys His Lys Leu 
225                 230     


<210>  65
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  DNA sequence NKG2A fragment

<400>  65
ctgaatacaa gaactcagaa agcacgtcat tgtggccatt gtcctgagga gtggattaca       60

tattccaaca gttgttacta cattggtaag gaaagaagaa cttgggaaga gagtttgctg      120

gcctgtactt cgaagaactc cagtctgctt tctatagata atgaagaaga aatgaaattt      180

ctgtccatca tttcaccatc ctcatggatt ggtgtgtttc gtaacagcag tcatcatcca      240

tgggtgacaa tgaatggttt ggctttcaaa catgagataa aagactcaga taatgctgaa      300

cttaactgtg cagtgctaca agtaaatcga cttaaatcag cccagtgtgg atcttcaata      360

atatatcatt gtaagcataa gctt                                             384


<210>  66
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino Acid sequence NKG2A fragment

<400>  66

Leu Asn Thr Arg Thr Gln Lys Ala Arg His Cys Gly His Cys Pro Glu 
1               5                   10                  15      


Glu Trp Ile Thr Tyr Ser Asn Ser Cys Tyr Tyr Ile Gly Lys Glu Arg 
            20                  25                  30          


Arg Thr Trp Glu Glu Ser Leu Leu Ala Cys Thr Ser Lys Asn Ser Ser 
        35                  40                  45              


Leu Leu Ser Ile Asp Asn Glu Glu Glu Met Lys Phe Leu Ser Ile Ile 
    50                  55                  60                  


Ser Pro Ser Ser Trp Ile Gly Val Phe Arg Asn Ser Ser His His Pro 
65                  70                  75                  80  


Trp Val Thr Met Asn Gly Leu Ala Phe Lys His Glu Ile Lys Asp Ser 
                85                  90                  95      


Asp Asn Ala Glu Leu Asn Cys Ala Val Leu Gln Val Asn Arg Leu Lys 
            100                 105                 110         


Ser Ala Gln Cys Gly Ser Ser Ile Ile Tyr His Cys Lys His Lys Leu 
        115                 120                 125             


<210>  67
<211>  402
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  DNA sequence CD94 fragment

<400>  67
ccaggaccca acatagaact ccagaaagac tctgactgct gttcttgcca agaaaaatgg       60

gttgggtacc ggtgcaactg ttacttcatt tccagtgaac agaaaacttg gaacgaaagt      120

cggcatctct gtgcttctca gaaatccagc ctgcttcagc ttcaaaacac agatgaactg      180

gattttatga gctccagtca acaattttac tggattggac tctcttacag tgaggagcac      240

accgcctggt tgtgggagaa tggctctgca ctctcccagt atctatttcc atcatttgaa      300

acttttaata caaagaactg catagcgtat aatccaaatg gaaatgcttt agatgaatcc      360

tgtgaagata aaaatcgtta tatctgtaag caacagctca tt                         402


<210>  68
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence CD94 fragment

<400>  68

Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys 
1               5                   10                  15      


Gln Glu Lys Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser 
            20                  25                  30          


Glu Gln Lys Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys 
        35                  40                  45              


Ser Ser Leu Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser 
    50                  55                  60                  


Ser Ser Gln Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His 
65                  70                  75                  80  


Thr Ala Trp Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe 
                85                  90                  95      


Pro Ser Phe Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro 
            100                 105                 110         


Asn Gly Asn Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile 
        115                 120                 125             


Cys Lys Gln Gln Leu Ile 
    130                 


<210>  69
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HLA-E Signal Peptide

<400>  69

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala 
            20      


<210>  70
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HLA-G Signal Peptide

<400>  70

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala 
            20                  


