                         SEQUENCE LISTING

<110>  Autolus Limited
 
<120>  POLYPEPTIDES AND METHODS

<130>  |P10494GBWO|

<140>  PCT/GB2019/050286
<141>  2019-02-01

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 
1               5                   10                  15      


Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 
            20                  25                  30          


Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 
        35                  40                  45              


Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 
    50                  55                  60                  


Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro 
65                  70                  75                  80  


Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro Ser 
                85                  90                  95      


Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr Gly Pro Gly 
            100                 105                 110         


Ala Glu Gly His Ser Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 
        115                 120                 125             


Ala Ser Thr Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 
    130                 135                 140                 


Gly Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 
145                 150                 155                 160 


Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 
                165                 170                 175     


Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly 
            180                 185                 190         


Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala Thr 
        195                 200                 205             


Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly Asp Thr Pro 
    210                 215                 220                 


Pro Gly Arg Lys Pro Gly Ser Pro Val Trp Gly Glu Gly Ser Tyr Leu 
225                 230                 235                 240 


Ser Ser Tyr Pro Thr Cys Pro Ala Gln Ala Trp Cys Ser Arg Ser Ala 
                245                 250                 255     


Leu Arg Ala Pro Ser Ser Ser Leu Gly Ala Phe Phe Ala Gly Asp Leu 
            260                 265                 270         


Pro Pro Pro Leu Gln Ala Gly Ala Ala 
        275                 280     


<210>  2
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 
1               5                   10                  15      


Leu Pro Thr Gly Val Gly Gly 
            20              


<210>  3
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly 
1               5                   10                  15      


Lys Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro 
            20                  25                  30          


Gly Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu 
        35                  40                  45              


Asp Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr 
    50                  55                  60                  


Asn Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu 
65                  70                  75                  80  


Pro Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser 
                85                  90                  95      


Thr Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys 
            100                 105                 110         


Pro Gln Glu Pro Leu Arg Gly Thr Pro Gly Gly 
        115                 120             


<210>  4
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu 
1               5                   10                  15      


Phe Asp Leu Leu Leu 
            20      


<210>  5
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  5

Thr Cys Ser Cys Leu Cys Asp Pro Ala Gly Pro Leu Pro Ser Pro Ala 
1               5                   10                  15      


Thr Thr Thr Arg Leu Arg Ala Leu Gly Ser His Arg Leu His Pro Ala 
            20                  25                  30          


Thr Glu Thr Gly Gly Arg Glu Ala Thr Ser Ser Pro Arg Pro Gln Pro 
        35                  40                  45              


Arg Asp Arg Arg Trp Gly Asp Thr Pro Pro Gly Arg Lys Pro Gly Ser 
    50                  55                  60                  


Pro Val Trp Gly Glu Gly Ser Tyr Leu Ser Ser Tyr Pro Thr Cys Pro 
65                  70                  75                  80  


Ala Gln Ala Trp Cys Ser Arg Ser Ala Leu Arg Ala Pro Ser Ser Ser 
                85                  90                  95      


Leu Gly Ala Phe Phe Ala Gly Asp Leu Pro Pro Pro Leu Gln Ala Gly 
            100                 105                 110         


Ala Ala 
        


<210>  6
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fmc63-dPreTalpha (figure 5b)

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys 
        115                 120                 125             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Thr 
            260                 265                 270         


Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly Lys 
        275                 280                 285             


Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro Gly 
    290                 295                 300                 


Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu Asp 
305                 310                 315                 320 


Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr Asn 
                325                 330                 335     


Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu Pro 
            340                 345                 350         


Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser Thr 
        355                 360                 365             


Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys Pro 
    370                 375                 380                 


Gln Glu Pro Leu Arg Gly Thr Pro Gly Gly Ala Leu Trp Leu Gly Val 
385                 390                 395                 400 


Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu Phe Asp Leu Leu Leu Gln 
                405                 410                 415     


Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr Asp Pro Thr 
            420                 425                 430         


Arg Arg 
        


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fmc63-dPreTalpha (figure 5b)

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  8
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fmc63-dPreTalpha (figure 5b)

<400>  8

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
    130                 135                 140                 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
145                 150                 155                 160 


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
            180                 185                 190         


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
        195                 200                 205             


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
    210                 215                 220                 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro 
                245                 250     


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated inert endodomain anchor derived from CD19

<400>  9

Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr Asp Pro 
1               5                   10                  15      


Thr Arg Arg 
            


<210>  10
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fmc63-PreTalpha-CD28 (figure 6a)

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys 
        115                 120                 125             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Thr 
            260                 265                 270         


Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly Lys 
        275                 280                 285             


Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro Gly 
    290                 295                 300                 


Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu Asp 
305                 310                 315                 320 


Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr Asn 
                325                 330                 335     


Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu Pro 
            340                 345                 350         


Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser Thr 
        355                 360                 365             


Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys Pro 
    370                 375                 380                 


Gln Glu Pro Leu Arg Gly Thr Pro Gly Gly Ala Leu Trp Leu Gly Val 
385                 390                 395                 400 


Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu Phe Asp Leu Leu Leu Arg 
                405                 410                 415     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            420                 425                 430         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        435                 440                 445             


Arg Asp Phe Ala Ala Tyr Arg Ser 
    450                 455     


<210>  11
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain CD28

<400>  11

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  12
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fmc63-PreTalpha-CD28 (figure 6b)

<400>  12

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys 
        115                 120                 125             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Thr 
            260                 265                 270         


Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly Lys 
        275                 280                 285             


Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro Gly 
    290                 295                 300                 


Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu Asp 
305                 310                 315                 320 


Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr Asn 
                325                 330                 335     


Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu Pro 
            340                 345                 350         


Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser Thr 
        355                 360                 365             


Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys Pro 
    370                 375                 380                 


Gln Glu Pro Leu Arg Gly Thr Pro Gly Gly Ala Leu Trp Leu Gly Val 
385                 390                 395                 400 


Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu Phe Asp Leu Leu Leu Arg 
                405                 410                 415     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            420                 425                 430         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        435                 440                 445             


Arg Asp Phe Ala Ala Tyr Arg Ser 
    450                 455     


<210>  13
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3e-41BB-2A (figure 6b)

<400>  13

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr 
            20                  25                  30          


Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro 
        35                  40                  45              


Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile 
    50                  55                  60                  


Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu 
65                  70                  75                  80  


Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys 
                85                  90                  95      


Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu 
            100                 105                 110         


Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val 
        115                 120                 125             


Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu 
    130                 135                 140                 


Leu Val Tyr Tyr Trp Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
145                 150                 155                 160 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                165                 170                 175     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            180                 185                 190         


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
        195                 200                 205             


Gly Pro 
    210 


<210>  14
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ectodomain CD3e

<400>  14

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp 
            100                 


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane CD3e

<400>  15

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain 41BB

<400>  16

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A

<400>  17

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  18
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fmc63-PreTalpha-TetRB (figure 7a)

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys 
        115                 120                 125             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Thr 
            260                 265                 270         


Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly Lys 
        275                 280                 285             


Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro Gly 
    290                 295                 300                 


Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu Asp 
305                 310                 315                 320 


Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr Asn 
                325                 330                 335     


Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu Pro 
            340                 345                 350         


Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser Thr 
        355                 360                 365             


Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys Pro 
    370                 375                 380                 


Gln Glu Pro Leu Arg Gly Thr Pro Gly Gly Ala Leu Trp Leu Gly Val 
385                 390                 395                 400 


Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu Phe Asp Leu Leu Leu Arg 
                405                 410                 415     


Ser Lys Arg Ser Arg Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn 
            420                 425                 430         


Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr 
        435                 440                 445             


Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp 
    450                 455                 460                 


His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met 
465                 470                 475                 480 


Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp 
                485                 490                 495     


Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu 
            500                 505                 510         


Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu 
        515                 520                 525             


Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln 
    530                 535                 540                 


Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His 
545                 550                 555                 560 


Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys 
                565                 570                 575     


Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg 
            580                 585                 590         


Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu 
        595                 600                 605             


Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys 
    610                 615                 620                 


Glu Ser Gly Ser 
625             


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Anchor

<400>  19

Arg Ser Lys Arg Ser Arg 
1               5       


<210>  20
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetRB

<400>  20

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser 
        195                 200                 205         


<210>  21
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIP-CD148-2A (figure 7a)

<400>  21

Met Trp Thr Trp Asn Ala Tyr Ala Phe Ala Ala Pro Ser Gly Gly Gly 
1               5                   10                  15      


Ser Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu Val Ser Phe Ser 
            20                  25                  30          


Gln Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val Glu Asn Phe Glu 
        35                  40                  45              


Ala Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys Gly Phe Ala Glu 
    50                  55                  60                  


Glu Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln Pro Lys Tyr Ala 
65                  70                  75                  80  


Ala Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr Asn Asn Val Leu 
                85                  90                  95      


Pro Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln Thr His Ser Thr 
            100                 105                 110         


Asp Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr His Ser Lys Lys 
        115                 120                 125             


Asp Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr Leu Lys Asp Phe 
    130                 135                 140                 


Trp Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile Ile Met Leu Thr 
145                 150                 155                 160 


Lys Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu Tyr Trp Pro Ser 
                165                 170                 175     


Lys Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala Met Thr Ser Glu 
            180                 185                 190         


Ile Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr Val Lys Asn Ile 
        195                 200                 205             


Gln Thr Ser Glu Ser His Pro Leu Arg Gln Phe His Phe Thr Ser Trp 
    210                 215                 220                 


Pro Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu Ile Asn Phe Arg 
225                 230                 235                 240 


Tyr Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro Glu Ser Pro Ile 
                245                 250                 255     


Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala 
            260                 265                 270         


Ile Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn Thr Val Asp Val 
        275                 280                 285             


Tyr Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro Leu Met Val Gln 
    290                 295                 300                 


Thr Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val Leu Asp Ile Val 
305                 310                 315                 320 


Arg Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr Gln Asn Thr Thr 
                325                 330                 335     


Ala Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr Thr Phe Gly Lys 
            340                 345                 350         


Thr Asn Gly Tyr Ile Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
        355                 360                 365             


Asp Val Glu Glu Asn Pro Gly Pro 
    370                 375     


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIP

<400>  22

Met Trp Thr Trp Asn Ala Tyr Ala Phe Ala Ala Pro 
1               5                   10          


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Ser Gly Gly Gly Ser 
1               5   


<210>  24
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endodomain CD148

<400>  24

Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu Val Ser Phe Ser Gln 
1               5                   10                  15      


Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val Glu Asn Phe Glu Ala 
            20                  25                  30          


Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys Gly Phe Ala Glu Glu 
        35                  40                  45              


Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln Pro Lys Tyr Ala Ala 
    50                  55                  60                  


Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr Asn Asn Val Leu Pro 
65                  70                  75                  80  


Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln Thr His Ser Thr Asp 
                85                  90                  95      


Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr His Ser Lys Lys Asp 
            100                 105                 110         


Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr Leu Lys Asp Phe Trp 
        115                 120                 125             


Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile Ile Met Leu Thr Lys 
    130                 135                 140                 


Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu Tyr Trp Pro Ser Lys 
145                 150                 155                 160 


Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala Met Thr Ser Glu Ile 
                165                 170                 175     


Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr Val Lys Asn Ile Gln 
            180                 185                 190         


Thr Ser Glu Ser His Pro Leu Arg Gln Phe His Phe Thr Ser Trp Pro 
        195                 200                 205             


Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu Ile Asn Phe Arg Tyr 
    210                 215                 220                 


Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro Glu Ser Pro Ile Leu 
225                 230                 235                 240 


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala Ile 
                245                 250                 255     


Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn Thr Val Asp Val Tyr 
            260                 265                 270         


Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro Leu Met Val Gln Thr 
        275                 280                 285             


Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val Leu Asp Ile Val Arg 
    290                 295                 300                 


Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr Gln Asn Thr Thr Ala 
305                 310                 315                 320 


Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr Thr Phe Gly Lys Thr 
                325                 330                 335     


Asn Gly Tyr Ile Ala 
            340     


<210>  25
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fmc63-PreTalpha-FRB (figure 7b)

<400>  25

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys 
        115                 120                 125             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Thr 
            260                 265                 270         


Pro Phe Pro Ser Leu Ala Pro Pro Ile Met Leu Leu Val Asp Gly Lys 
        275                 280                 285             


Gln Gln Met Val Val Val Cys Leu Val Leu Asp Val Ala Pro Pro Gly 
    290                 295                 300                 


Leu Asp Ser Pro Ile Trp Phe Ser Ala Gly Asn Gly Ser Ala Leu Asp 
305                 310                 315                 320 


Ala Phe Thr Tyr Gly Pro Ser Pro Ala Thr Asp Gly Thr Trp Thr Asn 
                325                 330                 335     


Leu Ala His Leu Ser Leu Pro Ser Glu Glu Leu Ala Ser Trp Glu Pro 
            340                 345                 350         


Leu Val Cys His Thr Gly Pro Gly Ala Glu Gly His Ser Arg Ser Thr 
        355                 360                 365             


Gln Pro Met His Leu Ser Gly Glu Ala Ser Thr Ala Arg Thr Cys Pro 
    370                 375                 380                 


Gln Glu Pro Leu Arg Gly Thr Pro Gly Gly Ala Leu Trp Leu Gly Val 
385                 390                 395                 400 


Leu Arg Leu Leu Leu Phe Lys Leu Leu Leu Phe Asp Leu Leu Leu Arg 
                405                 410                 415     


Ser Lys Arg Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu 
            420                 425                 430         


Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met 
        435                 440                 445             


Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln 
    450                 455                 460                 


Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met 
465                 470                 475                 480 


Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys 
                485                 490                 495     


Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile 
            500                 505                 510         


Ser Lys 
        


<210>  26
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB

<400>  26

Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90              


<210>  27
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12-CD148-2A (figure 7b)

<400>  27

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu Val Ser 
        115                 120                 125             


Phe Ser Gln Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val Glu Asn 
    130                 135                 140                 


Phe Glu Ala Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys Gly Phe 
145                 150                 155                 160 


Ala Glu Glu Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln Pro Lys 
                165                 170                 175     


Tyr Ala Ala Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr Asn Asn 
            180                 185                 190         


Val Leu Pro Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln Thr His 
        195                 200                 205             


Ser Thr Asp Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr His Ser 
    210                 215                 220                 


Lys Lys Asp Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr Leu Lys 
225                 230                 235                 240 


Asp Phe Trp Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile Ile Met 
                245                 250                 255     


Leu Thr Lys Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu Tyr Trp 
            260                 265                 270         


Pro Ser Lys Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala Met Thr 
        275                 280                 285             


Ser Glu Ile Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr Val Lys 
    290                 295                 300                 


Asn Ile Gln Thr Ser Glu Ser His Pro Leu Arg Gln Phe His Phe Thr 
305                 310                 315                 320 


Ser Trp Pro Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu Ile Asn 
                325                 330                 335     


Phe Arg Tyr Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro Glu Ser 
            340                 345                 350         


Pro Ile Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe 
        355                 360                 365             


Ile Ala Ile Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn Thr Val 
    370                 375                 380                 


Asp Val Tyr Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro Leu Met 
385                 390                 395                 400 


Val Gln Thr Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val Leu Asp 
                405                 410                 415     


Ile Val Arg Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr Gln Asn 
            420                 425                 430         


Thr Thr Ala Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr Thr Phe 
        435                 440                 445             


Gly Lys Thr Asn Gly Tyr Ile Ala Glu Gly Arg Gly Ser Leu Leu Thr 
    450                 455                 460                 


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
465                 470                 


<210>  28
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12

<400>  28

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105                 110 


