                         SEQUENCE LISTING

<110>  Aarhus Universitet
 
<120>  Modified immunomodulatory peptide

<130>  P4813PC00

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Val Lys Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys 
1               5                   10                  15      


Gly Leu Glu Val Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu 
            20                  25                  30          


Leu Ser Asn Asp Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp 
        35                  40                  45              


Lys Ile Gln Ile Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala 
    50                  55                  60                  


Gly Leu Gly Lys Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Ala Glu Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro 
                85                  90                  95      


Ala Leu Ser Arg Lys Arg Lys Lys 
            100                 


<210>  2
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Val Lys Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys 
1               5                   10                  15      


Gly Leu Glu Val Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu 
            20                  25                  30          


Leu Ser Asn Asp Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp 
        35                  40                  45              


Lys Ile Gln Ile Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala 
    50                  55                  60                  


Gly Leu Gly Lys Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Ala Glu Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro 
                85                  90                  95      


Ala Leu Ser Arg Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala 
            100                 105                 110         


Pro Ser Thr Ser Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro 
        115                 120                 125             


Gly Ala Gln Lys Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys 
    130                 135                 140                 


Gly Ser Lys Val Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly 
145                 150                 155                 160 


Ala Gly Met Ser Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser 
                165                 170                 175     


Leu Ser Ala Pro Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val 
            180                 185                 190         


Ala Lys Cys Gln Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro 
        195                 200                 205             


Val Ile Val Lys Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr 
    210                 215                 220                 


Pro Glu Met Glu Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln 
225                 230                 235                 240 


Thr Gln Phe Phe His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys 
                245                 250                 255     


Phe Asn Gly Lys Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp 
            260                 265                 270         


Ser Leu Leu Glu Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro 
        275                 280                 285             


Asn Gln Thr Phe Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu 
    290                 295                 300                 


Thr Leu Lys Ile Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val 
305                 310                 315                 320 


Tyr Gly Val Phe Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr 
                325                 330                 335     


Ile Tyr Glu Ile Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr 
            340                 345                 350         


Gly Gln Cys His Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu 
        355                 360                 365             


Phe Cys Phe Arg Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser 
    370                 375                 380                 


Glu Met His Ser Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn 
385                 390                 395                 400 


Asn Asp Pro Lys Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro 
                405                 410                 415     


Tyr Pro Ser Glu Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr 
            420                 425                 430         


Pro Gln Met Pro Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys 
        435                 440                 445             


Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile 
    450                 455                 460                 


Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly 
465                 470                 475                 480 


Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro 
                485                 490                 495     


Ser Ser Ser Phe Leu Thr Thr Lys Ser Glu Asp Thr Ile Ser Lys Met 
            500                 505                 510         


Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro 
        515                 520                 525             


Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr 
    530                 535                 540                 


Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Leu 
545                 550                 555                 560 


Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser Ile Glu Asp Ser 
                565                 570                 575     


Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn Ala Thr Glu Ser 
            580                 585                 590         


Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe His Ala Thr Val 
        595                 600                 605             


Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe Asn Ile Asp Leu 
    610                 615                 620                 


Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile Ala Asn Tyr Val 
625                 630                 635                 640 


Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr Leu Val Ala Asp 
                645                 650                 655     


Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly Leu Ile Arg Ser 
            660                 665                 670         


Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser Gln Thr Lys Gly 
        675                 680                 685             


Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys Asn Val Arg Gly 
    690                 695                 700                 


Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly Lys Met Glu Val 
705                 710                 715                 720 


Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu Glu Gly Asp Lys 
                725                 730                 735     


Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser Gly Asn Thr Gly 
            740                 745                 750         


Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val Ile Lys Thr Arg 
        755                 760                 765             


Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser Met Glu Thr Ser 
    770                 775                 780                 


Pro Asp Phe Phe Phe 
785                 


<210>  3
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Gly Asp His Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asp Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala Asp Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala Val Pro 
            340                 345                 350         


Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Lys Pro Leu Pro Leu Arg Thr Asp Phe Ser 
    370                 375                 


<210>  4
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

       X is selected from any natural and unnatural amino acid residues,
       with the proviso that X is not tyrosine (Y).

<400>  4

Lys Lys Xaa Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

       X is selected from any natural and unnatural amino acid residues,
       with the proviso that X is not lysine (K).

<400>  5

Lys Lys Tyr Lys Asn Ile Val Leu Leu Xaa Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  7

Ala Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  8

Lys Ala Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  9

Lys Lys Ala Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  10

Lys Lys Tyr Ala Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  11

Lys Lys Tyr Lys Ala Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  12

Lys Lys Tyr Lys Asn Ala Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  13

Lys Lys Tyr Lys Asn Ile Ala Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  14

Lys Lys Tyr Lys Asn Ile Val Ala Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  15

Lys Lys Tyr Lys Asn Ile Val Leu Ala Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  16

Lys Lys Tyr Lys Asn Ile Val Leu Leu Ala Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  17

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Ala Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  18

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Ala Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  19

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Ala Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  20

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Ala Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  21

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ala Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  22

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Ala 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  23

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Ala Tyr His Phe 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  24

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Ala His Phe 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  25

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr Ala Phe 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  26

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Ala 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

<400>  27

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Ala Val Ile Asn 
1               5                   10                  15      


Asp Tyr Ala Ala 
            20  


<210>  28
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu Thr Leu Lys Lys Glu 
1               5                   10                  15      


Lys Leu Lys Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30      


<210>  29
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

       X is selected from any natural and unnatural amino acid residues,
       with the proviso that X is not Glutamic Acid (E).

<400>  29

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Xaa Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  An immunomodulatory polypeptide derived from the pyrin domain of 
       human IFI16 with amino acid residue changes.

       X is selected from any natural and unnatural amino acid residues,
       with the proviso that X is not aspartic acid (D).

<400>  30

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Xaa Tyr His Phe 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Immunomodulatory peptide.

       X is selected from any natural and unnatural amino acid residues,
       with the proviso that X3 is not tyrosine (Y) and X10 is not 
       lysine (K) and X13 is not glutamic acid (E) and X17 is not aspartic acid (D).
       

<400>  31

Lys Lys Xaa Lys Asn Ile Val Leu Leu Xaa Gly Leu Xaa Val Ile Asn 
1               5                   10                  15      


Xaa Tyr His Phe 
            20  


