                         SEQUENCE LISTING

<110>  Lonza Ltd
 
<120>  HOST CELL FOR PRODUCING A PROTEIN OF INTEREST

<130>  LO007P

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  587
<212>  PRT
<213>  Komagataella phaffii

<400>  1

Met Lys Phe Ala Ile Ser Thr Leu Leu Ile Ile Leu Gln Ala Ala Ala 
1               5                   10                  15      


Val Phe Ala Ala Phe Pro Ile Ser Asp Ile Thr Val Val Ser Glu Arg 
            20                  25                  30          


Thr Asp Ala Ser Thr Ala Tyr Leu Ser Asp Trp Phe Val Val Ser Phe 
        35                  40                  45              


Val Phe Ser Thr Ala Gly Ser Asp Glu Thr Ile Ala Gly Asp Ala Thr 
    50                  55                  60                  


Ile Glu Val Ser Ile Pro Asn Glu Leu Glu Phe Val Gln Tyr Pro Asp 
65                  70                  75                  80  


Ser Val Asp Pro Ser Val Ser Glu Phe Phe Thr Thr Ala Gly Val Gln 
                85                  90                  95      


Val Leu Ser Thr Ala Phe Asp Tyr Asp Ser His Val Leu Thr Phe Thr 
            100                 105                 110         


Phe Ser Asp Pro Gly Gln Val Ile Thr Asp Leu Glu Gly Val Val Phe 
        115                 120                 125             


Phe Thr Leu Lys Leu Ser Glu Gln Phe Thr Glu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Gln His Thr Phe Asp Phe Glu Thr Ser Asp Gln Thr Tyr Ser Pro Ser 
145                 150                 155                 160 


Val Asp Leu Val Ala Leu Asp Arg Ser Gln Pro Ile Lys Leu Ser Asn 
                165                 170                 175     


Ala Val Thr Gly Gly Val Glu Trp Phe Val Asp Ile Pro Gly Ala Phe 
            180                 185                 190         


Gly Asp Ile Thr Asn Ile Asp Ile Ser Thr Val Gln Thr Pro Gly Thr 
        195                 200                 205             


Phe Asp Cys Ser Glu Val Lys Tyr Ala Val Gly Ser Ser Leu Asn Glu 
    210                 215                 220                 


Phe Gly Asp Phe Thr Pro Gln Asp Arg Thr Thr Phe Phe Ser Asn Ser 
225                 230                 235                 240 


Ser Ser Gly Glu Trp Ile Pro Ile Thr Pro Ala Ser Gly Leu Pro Val 
                245                 250                 255     


Glu Ser Phe Glu Cys Gly Asp Gly Thr Ile Ser Leu Ser Phe Ala Gly 
            260                 265                 270         


Glu Leu Ala Asp Asp Glu Val Leu Arg Val Ser Phe Leu Ser Asn Leu 
        275                 280                 285             


Ala Asp Asp Val Leu Glu Val Gln Asn Val Val Asn Val Asp Leu Thr 
    290                 295                 300                 


Thr Ala Asp Ser Arg Lys Arg Ala Leu Thr Ser Phe Val Leu Asp Glu 
305                 310                 315                 320 


Pro Phe Tyr Arg Ala Ser Arg Thr Asp Thr Ala Ala Phe Glu Ala Phe 
                325                 330                 335     


Ala Ala Val Pro Ala Asp Gly Asp Ile Thr Ser Thr Ser Thr Ala Ile 
            340                 345                 350         


Thr Ser Val Thr Ala Thr Val Thr His Thr Thr Val Thr Ser Val Cys 
        355                 360                 365             


Tyr Val Cys Ala Glu Thr Pro Val Thr Val Thr Tyr Thr Ala Pro Val 
    370                 375                 380                 


Ile Thr Asn Pro Ile Tyr Tyr Thr Thr Lys Val His Val Cys Asn Val 
385                 390                 395                 400 


Cys Ala Glu Thr Pro Ile Thr Tyr Thr Val Thr Ile Pro Cys Glu Thr 
                405                 410                 415     


Asp Glu Tyr Ala Pro Ala Lys Pro Thr Gly Thr Glu Gly Glu Lys Ile 
            420                 425                 430         


Val Thr Val Ile Thr Lys Glu Gly Gly Asp Lys Tyr Thr Lys Thr Tyr 
        435                 440                 445             


Glu Glu Val Thr Tyr Thr Lys Thr Tyr Pro Lys Gly Gly His Glu Asp 
    450                 455                 460                 


His Ile Val Thr Val Lys Thr Lys Glu Gly Gly Glu Lys Val Thr Lys 
465                 470                 475                 480 


Thr Tyr Glu Glu Val Thr Tyr Thr Lys Gly Pro Glu Ile Val Thr Val 
                485                 490                 495     


Val Thr Lys Glu Gly Gly Glu Lys Val Thr Thr Thr Tyr His Asp Val 
            500                 505                 510         


Pro Glu Val Val Thr Val Ile Thr Lys Glu Gly Gly Glu Lys Val Thr 
        515                 520                 525             


Thr Thr Tyr Pro Ala Thr Tyr Pro Ala Thr Tyr Thr Glu Gly His Ser 
    530                 535                 540                 


Ala Gly Val Pro Thr Ser Ala Ser Thr Pro Pro Gln Ala Thr Tyr Thr 
545                 550                 555                 560 


Val Ser Glu Ala Gln Val Asn Leu Gly Ser Lys Ser Ala Val Gly Leu 
                565                 570                 575     


Leu Ala Ile Val Pro Met Leu Phe Leu Ala Ile 
            580                 585         


<210>  2
<211>  1764
<212>  DNA
<213>  Komagataella phaffii

<400>  2
atgaagttcg caatttcaac acttcttatt atcctacagg ctgccgctgt ttttgctgcc       60

ttccctatat ctgatatcac agttgtcagt gaaagaactg acgcatcgac tgcctatctg      120

tcggactggt ttgttgtttc attcgttttt agcactgctg gcagtgacga aacaatcgct      180

ggtgacgcta ctattgaagt ctctattcct aatgagctag agtttgttca ataccctgat      240

tccgttgacc catccgtttc cgaattcttt acaaccgctg gtgttcaagt tttgagtacc      300

gcatttgatt atgacagcca tgttttgact ttcactttct ctgacccagg tcaagttatt      360

actgaccttg aaggagttgt tttctttaca ctcaaactca gtgagcagtt caccgagtct      420

gcttcccctg gccaacacac cttcgacttc gaaacctctg atcagaccta cagtccttct      480

gtcgacttgg tcgcacttga cagatctcag ccaatcaagc tgagcaacgc tgtgaccggt      540

ggtgttgaat ggtttgttga tattccaggt gcatttggag acatcaccaa cattgacatc      600

agcactgttc agaccccagg tacctttgac tgttcggagg ttaagtatgc tgtcggaagc      660

agcctgaacg aatttggtga ctttacccca caggatagaa caactttctt cagcaattcg      720

tccagtggag aatggattcc aattactcct gcttcaggtc ttccagttga aagctttgag      780

tgtggtgatg gtaccatctc tttgagcttt gccggtgaat tagctgacga tgaagttctt      840

agagtttctt tcctatcaaa cctggctgat gatgttcttg aagttcagaa cgttgtgaat      900

gttgacctca ccactgcaga ctcgcgtaag agagcattga cttcgttcgt ccttgatgag      960

ccattttacc gtgctagcag aaccgacaca gctgccttcg aagcttttgc agccgtacca     1020

gctgacggag atattacttc tacttcaact gccattacca gtgttactgc aacagttacc     1080

cacaccactg ttacatccgt ctgttacgtt tgtgctgaaa ctcctgttac cgttacctac     1140

accgctccag tcattactaa cccaatttac tataccacta aggttcacgt ttgtaacgtc     1200

tgtgctgaaa caccaattac ctacactgtt accattcctt gtgaaactga tgaatacgct     1260

ccagctaagc caactggcac tgagggtgag aagatcgtca ccgttattac aaaagaaggt     1320

ggtgacaagt acaccaagac atacgaagaa gtcacttaca ccaagactta tcccaagggt     1380

ggtcatgagg accatattgt cactgtcaaa actaaagaag gtggtgaaaa ggtcactaag     1440

acttacgagg aagtcaccta taccaagggt cctgaaattg ttactgttgt taccaaggag     1500

ggtggggaga aagttaccac tacttaccac gatgttcctg aggttgttac tgttatcacc     1560

aaggaaggtg gagagaaagt tactactact tacccagcta cttacccagc tacctacaca     1620

gaaggccaca gtgctggagt tccaacaagt gctagcaccc ctcctcaagc tacttacact     1680

gtgagtgagg ctcaagtcaa cttgggttcc aaatctgctg ttggtctgtt agcaatcgtc     1740

ccaatgctct tcttggctat ctaa                                            1764


<210>  3
<211>  348
<212>  PRT
<213>  Komagataella phaffii

<400>  3

Met Gln Val Lys Ser Ile Val Asn Leu Leu Leu Ala Cys Ser Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Leu Glu His Ala His His Gln His Asp Lys Arg Gly 
            20                  25                  30          


Val Val Val Val Thr Lys Thr Ile Val Val Asp Gly Ser Thr Val Glu 
        35                  40                  45              


Ala Thr Ala Ala Ala Gln Val Gln Glu His Ala Glu Thr Phe Ala Glu 
    50                  55                  60                  


Ser Thr Pro Ser Ala Val Val Ser Ser Ser Ser Ala Pro Ser Ser Ala 
65                  70                  75                  80  


Ser Ser Ala Ser Ala Pro Ala Ser Ser Gly Ser Phe Ser Ala Gly Thr 
                85                  90                  95      


Lys Gly Val Thr Tyr Ser Pro Tyr Gln Ala Gly Gly Gly Cys Lys Thr 
            100                 105                 110         


Ala Glu Glu Val Ala Ser Asp Leu Ser Gln Leu Thr Gly Tyr Glu Ile 
        115                 120                 125             


Ile Arg Leu Tyr Gly Val Asp Cys Asn Gln Val Glu Asn Val Phe Lys 
    130                 135                 140                 


Ala Lys Ala Pro Gly Gln Lys Leu Phe Leu Gly Ile Phe Phe Val Asp 
145                 150                 155                 160 


Ala Ile Glu Ser Gly Val Ser Ala Ile Ala Ser Ala Val Lys Ser Tyr 
                165                 170                 175     


Gly Ser Trp Asp Asp Val His Thr Val Ser Val Gly Asn Glu Leu Val 
            180                 185                 190         


Asn Asn Gly Glu Ala Thr Val Ser Gln Ile Gly Gln Tyr Val Ser Thr 
        195                 200                 205             


Ala Lys Ser Ala Leu Arg Ser Ala Gly Phe Thr Gly Pro Val Leu Ser 
    210                 215                 220                 


Val Asp Thr Phe Ile Ala Val Ile Asn Asn Pro Gly Leu Cys Asp Phe 
225                 230                 235                 240 


Ala Asp Glu Tyr Val Ala Val Asn Ala His Ala Phe Phe Asp Gly Gly 
                245                 250                 255     


Ile Ala Ala Ser Gly Ala Gly Asp Trp Ala Ala Glu Gln Ile Gln Arg 
            260                 265                 270         


Val Ser Ser Ala Cys Gly Gly Lys Asp Val Leu Ile Val Glu Ser Gly 
        275                 280                 285             


Trp Pro Ser Lys Gly Asp Thr Asn Gly Ala Ala Val Pro Ser Lys Ser 
    290                 295                 300                 


Asn Gln Gln Ala Ala Val Gln Ser Leu Gly Gln Lys Ile Gly Ser Ser 
305                 310                 315                 320 


Cys Ile Ala Phe Asn Ala Phe Asn Asp Tyr Trp Lys Ala Asp Gly Pro 
                325                 330                 335     


Phe Asn Ala Glu Lys Tyr Trp Gly Ile Leu Asp Ser 
            340                 345             


<210>  4
<211>  1047
<212>  DNA
<213>  Komagataella phaffii

<400>  4
atgcaagtta aatctatcgt taacctactg ttggcatgtt cgttggccgt ggccagacct       60

ttggagcacg cccaccatca acatgacaag agaggtgttg tcgtcgtgac caagaccatc      120

gttgtcgatg gttccaccgt tgaggctacc gcagcagccc aggtccaaga gcacgctgaa      180

actttcgcag agtcgactcc ttcagctgtt gtttccagtt catcagctcc ttcctctgct      240

tcttctgctt ccgctcctgc ctcttccggt agcttctccg ctggaaccaa aggtgtcacc      300

tactctcctt accaagccgg tggtggctgt aagactgcag aggaggtcgc ttccgatctt      360

tcccagttga ccggctacga gatcatcaga ttgtacggtg ttgactgtaa ccaagtcgag      420

aacgtcttca aggccaaggc cccaggtcaa aagttgtttt tgggaatctt ctttgttgat      480

gctatcgaga gcggtgtcag tgctattgcc tccgctgtca agtcatacgg ttcttgggac      540

gatgtccaca ctgtctctgt tggtaacgag ttggtcaaca acggtgaggc cactgtttcc      600

caaatcggtc aatacgtttc taccgctaaa tctgccttga gatctgctgg tttcaccggt      660

ccagttcttt ctgtcgacac tttcattgct gtcatcaaca acccagggtt gtgtgacttt      720

gctgacgagt acgttgccgt taacgctcac gctttctttg acggtggcat tgctgcctct      780

ggagctggtg attgggctgc tgagcagatc caaagagttt cttccgcttg tggtggcaag      840

gatgtcctca ttgtcgagtc cggatggcct tcaaagggag acaccaacgg tgctgccgtt      900

ccttccaagt caaaccaaca ggctgctgtc caatctctag gtcagaagat cggttcttct      960

tgtattgctt tcaacgcttt caacgattac tggaaggccg atggtccttt caacgctgag     1020

aagtactggg gtatcctaga ctcctaa                                         1047


<210>  5
<211>  431
<212>  PRT
<213>  Komagataella phaffii

<400>  5

Met Lys Ile Ser Ala Leu Thr Ala Cys Ala Val Thr Leu Ala Gly Leu 
1               5                   10                  15      


Ala Ile Ala Ala Pro Ala Pro Lys Pro Glu Asp Cys Thr Thr Thr Val 
            20                  25                  30          


Gln Lys Arg His Gln His Lys Arg Ala Val Ala Tyr Asp Tyr Val Tyr 
        35                  40                  45              


Val Thr Val Thr Ile Asn Gly Gln Gly Glu Thr Ile Ser Pro Thr Val 
    50                  55                  60                  


Val Ala Glu Leu Glu Thr Val Ser Thr Pro Ala Thr Ser Ser Ser Ala 
65                  70                  75                  80  


Val Ala Thr Ser Ser Ala Pro Ala Thr Thr Ser Ser Ile Pro Glu Thr 
                85                  90                  95      


Thr Ser Ala Gln Val Thr Thr Ser Ser Val Ala Glu Ser Thr Ser Ala 
            100                 105                 110         


Gln Phe Thr Ser Ser Thr Glu Glu Ala Ser Ser Ser Val Glu Gln Thr 
        115                 120                 125             


Thr Gln Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Gly Ser Ser Ser Gly Ser Ser Ser Gly Gly Ile Asp Gly 
145                 150                 155                 160 


Asp Leu Ser Trp Tyr Ser Gly Pro Gly Asn Lys Phe Gln Asp Gly Thr 
                165                 170                 175     


Ile Lys Cys Ser Glu Phe Pro Ser Gly Asn Gly Val Val Ala Leu Asp 
            180                 185                 190         


His Leu Gly Phe Gly Gly Trp Ser Gly Leu Tyr His Pro Ser Asp Thr 
        195                 200                 205             


Ser Thr Gly Gly Ile Cys Glu Pro Asp Thr Tyr Cys Ser Tyr Ala Cys 
    210                 215                 220                 


Gln Ser Gly Met Ser Lys Thr Gln Trp Pro Ser Glu Gln Pro Asp Asn 
225                 230                 235                 240 


Gly Val Ser Val Gly Gly Leu Tyr Cys Asp Ser Asp Gly Tyr Leu Tyr 
                245                 250                 255     


Arg Ser Lys Lys Asp Thr Asp Tyr Leu Cys Glu Trp Gly Ile Asp Val 
            260                 265                 270         


Ala Tyr Val Val Ser Glu Ile Gly Lys Thr Ala Ala Ile Cys Arg Thr 
        275                 280                 285             


Asp Tyr Pro Gly Thr Glu Asn Met Val Ile Pro Thr Val Val Ser Pro 
    290                 295                 300                 


Gly Gly Glu Leu Pro Leu Thr Thr Val Asp Gln Ser Ser Tyr Tyr Thr 
305                 310                 315                 320 


Trp Arg Gly Met Lys Thr Ser Ala Gln Tyr Tyr Val Asn Asp Ala Gly 
                325                 330                 335     


Val Asp Trp Thr Thr Gly Cys Thr Trp Gly Asp Tyr Gly Thr Asp Tyr 
            340                 345                 350         


Gly Asn Trp Ala Pro Leu Asn Phe Gly Ala Gly Tyr Asp Asn Gly Ile 
        355                 360                 365             


Ser Tyr Leu Ser Leu Ile Pro Asn Pro Asn Asn Lys Asp Ser Leu Asn 
    370                 375                 380                 


Tyr Asn Val Lys Ile Val Ala Tyr Asp Asp Ser Ser Val Val Ile Gly 
385                 390                 395                 400 


Glu Cys Lys Tyr Glu Asn Gly Ser Tyr Asn Gly Asn Gly Ser Asp Gly 
                405                 410                 415     


Cys Thr Val Ala Val Asn Ser Gly Lys Ala Lys Phe Val Leu Tyr 
            420                 425                 430     


<210>  6
<211>  1296
<212>  DNA
<213>  Komagataella phaffii

<400>  6
atgaagatat ccgctcttac agcctgcgct gttactctag ctggtcttgc aattgcagca       60

ccagctccaa agcctgaaga ttgtactact acagtgcaga aacgtcacca acacaaacgt      120

gctgtcgcat acgattacgt ttatgtcaca gtgactatca atggccaagg tgaaaccatt      180

tctccaactg ttgtggcaga acttgagacg gtttccacgc ctgcaacaag ctcatccgca      240

gttgcaactt cttctgctcc tgcaaccact tcttcaatcc cagagacaac ttctgcacaa      300

gtgaccacct cttctgttgc agagtccact tcagcgcaat tcacttcatc taccgaagaa      360

gcctcttctt ctgttgagca aacgactcaa tcaagttcaa gttcaagtcc aagttccagt      420

tccagttcaa gttcgagctc aggctctagt tcaggatcca gttccggtgg aatcgatgga      480

gacctaagct ggtactcagg tcctggaaac aaattccagg atggtactat aaagtgttcc      540

gagttcccat ccggtaacgg tgttgttgcc ttggaccatc tcggattcgg aggatggtca      600

ggattatacc acccatctga tacctctact ggtgggatct gtgaaccaga cacctactgc      660

tcttatgcct gccaatcagg tatgtcgaag acacaatggc catctgaaca accggacaat      720

ggtgtttccg ttggtggtct gtattgtgat tctgatggat acctttaccg ttccaagaaa      780

gacactgact atctatgtga atggggtatt gatgtcgcct atgttgtcag tgaaattggt      840

aaaactgctg ccatctgtag aaccgactat ccaggaactg aaaacatggt tataccaact      900

gttgtgagtc cgggtggaga actccctctg acaacagttg accaatcctc ttactatacg      960

tggaggggaa tgaagacttc ggcccaatac tacgtgaacg atgctggtgt tgactggacc     1020

accggttgta cctggggaga ctatggaacc gactacggta actgggcgcc attgaacttt     1080

ggtgccggtt acgacaacgg catttcatac ctttctttaa tccctaaccc taacaacaag     1140

gactccttga actataatgt caagattgtt gcttatgatg attcttctgt cgttatcggc     1200

gagtgcaagt atgaaaatgg ttcatacaat ggaaacggtt ccgacggttg taccgttgct     1260

gtcaacagcg gtaaggccaa gtttgtgttg tattaa                               1296


<210>  7
<211>  313
<212>  PRT
<213>  Komagataella phaffii

<400>  7

Met Lys Leu Ser Thr Asn Leu Ile Leu Ala Ile Ala Ala Ala Ser Ala 
1               5                   10                  15      


Val Val Ser Ala Ala Pro Val Ala Pro Ala Glu Glu Ala Ala Asn His 
            20                  25                  30          


Leu His Lys Arg Ala Tyr Tyr Thr Asp Thr Thr Lys Thr His Thr Phe 
        35                  40                  45              


Thr Glu Val Val Thr Val Tyr Arg Thr Leu Lys Pro Gly Glu Ser Ile 
    50                  55                  60                  


Pro Thr Asp Ser Pro Ser His Gly Gly Lys Ser Thr Lys Lys Gly Lys 
65                  70                  75                  80  


Gly Ser Thr Thr His Ser Gly Ala Pro Gly Ala Thr Ser Gly Ala Pro 
                85                  90                  95      


Thr Asp Asp Thr Thr Ser Thr Ser Gly Ser Val Gly Leu Pro Thr Ser 
            100                 105                 110         


Ala Thr Ser Val Thr Ser Ser Thr Ser Ser Ala Ser Thr Thr Ser Ser 
        115                 120                 125             


Gly Thr Ser Ala Thr Ser Thr Gly Thr Gly Thr Ser Thr Ser Thr Ser 
    130                 135                 140                 


Thr Gly Thr Gly Thr Gly Thr Thr Gly Thr Gly Thr Thr Ser Ser Ser 
145                 150                 155                 160 


Thr Ser Ser Ser Ala Thr Ser Thr Pro Thr Gly Ser Ile Asp Ala Ile 
                165                 170                 175     


Ser Gln Thr Leu Leu Asp Thr His Asn Asp Lys Arg Ala Leu His Gly 
            180                 185                 190         


Val Pro Asp Leu Thr Trp Ser Thr Glu Leu Ala Asp Tyr Ala Gln Gly 
        195                 200                 205             


Tyr Ala Asp Ser Tyr Thr Cys Gly Ser Ser Leu Glu His Thr Gly Gly 
    210                 215                 220                 


Pro Tyr Gly Glu Asn Leu Ala Ser Gly Tyr Ser Pro Ala Gly Ser Val 
225                 230                 235                 240 


Glu Ala Trp Tyr Asn Glu Ile Ser Asp Tyr Asp Phe Ser Asn Pro Gly 
                245                 250                 255     


Tyr Ser Ala Gly Thr Gly His Phe Thr Gln Val Val Trp Lys Ser Thr 
            260                 265                 270         


Thr Gln Leu Gly Cys Gly Tyr Lys Glu Cys Ser Thr Asp Arg Tyr Tyr 
        275                 280                 285             


Ile Ile Cys Glu Tyr Ala Pro Arg Gly Asn Ile Val Ser Ala Gly Tyr 
    290                 295                 300                 


Phe Glu Asp Asn Val Leu Pro Pro Val 
305                 310             


<210>  8
<211>  939
<212>  DNA
<213>  Komagataella phaffii

<400>  8
atgaagctct ccaccaattt gattctagct attgcagcag cttccgccgt tgtctcagct       60

gctccagttg ctccagccga agaggcagca aaccacttgc acaagcgtgc ttactacacc      120

gacacaacca agactcacac tttcactgag gttgttactg tctaccgaac tttgaaaccg      180

ggcgaaagta tcccaactga ctctccaagc cacggtggta aaagtactaa aaagggtaag      240

ggtagtacca ctcactctgg tgctccagga gctacctctg gtgctccaac tgacgacacc      300

acttcgacta gtggctcagt agggttacca actagcgcaa cttcagttac ctcttctacc      360

tcctctgcaa gtacaacaag cagtggaact tcagccacta gcactggtac cggtactagc      420

actagcacta gcactggtac tggtactggt actacaggca caggaaccac tagttccagc      480

actagctctt ctgctacttc gactccaacc ggttctatcg acgctatcag ccagacactt      540

ctggatactc acaatgataa gcgtgctttg cacggcgtcc cagaccttac ttggtctacc      600

gaactcgctg actacgccca aggttacgcc gattcataca cttgtggctc ttcattagaa      660

cacacaggtg gaccatacgg tgaaaatttg gcctctggat actctcctgc tggcagtgta      720

gaagcatggt acaacgagat cagcgactac gatttctcta acccaggtta ttctgctggt      780

accggtcact tcacccaagt tgtctggaaa tcaactacac agctgggctg tggatacaag      840

gagtgcagta ccgacagata ctacatcatc tgcgaatacg cacctcgtgg aaatattgtt      900

tctgccggct acttcgaaga caacgtcctg cctcctgtt                             939


<210>  9
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
gagagaacta atgcccagat aaacttgc                                          28


<210>  10
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
gttgtcgacc tgcagcgtac gatcaagtga gtgagtgact gttggtg                     47


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
cactcacttg atcgtacgct gcaggtcgac aac                                    33


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
cggtgagaat ggcaaaagct tatg                                              24


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
aagcccgatg cgccagagtt g                                                 21


<210>  14
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
ggctgagatc tgagtggatc tgatatcacc taataac                                37


<210>  15
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
taggtgatat cagatccact cagatctcag ccaatcaagc tg                          42


<210>  16
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
cgcttggtaa tagacagtgt tatgtgg                                           27


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
cacaggttca tccaccccgc                                                   20


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
ccatcttaca gattccagtc tctaagctgc                                        30


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetrapeptide

<400>  19

Glu Ala Glu Ala 
1               


<210>  20
<211>  615
<212>  PRT
<213>  Komagataella pastoris

<400>  20

Met Gln Leu Arg Val Ser Phe Ser Phe Asp Tyr Lys Asn Gly Gly Tyr 
1               5                   10                  15      


Pro Trp Thr Tyr Phe Asp Phe Pro His Thr Val Thr His Leu Ile Met 
            20                  25                  30          


Lys Phe Ala Ile Pro Thr Leu Phe Val Ile Leu Gln Ala Ala Ser Val 
        35                  40                  45              


Phe Ala Ala Phe Pro Ile Thr Asp Ile Thr Val Val Ser Glu Arg Thr 
    50                  55                  60                  


Asp Ala Ser Ile Ala Tyr Leu Ser Asp Trp Phe Leu Val Ser Phe Val 
65                  70                  75                  80  


Phe Ser Thr Ala Gly Ser Asp Glu Thr Leu Ala Gly Asp Ala Thr Ile 
                85                  90                  95      


Glu Val Ser Ile Pro Asp Glu Leu Glu Phe Val Gln Tyr Pro Glu Ser 
            100                 105                 110         


Val Asp Pro Ser Val Ser Glu Phe Phe Thr Thr Ala Gly Val Gln Val 
        115                 120                 125             


Leu Ser Thr Ala Phe Asp Tyr Asp Ser His Val Leu Thr Phe Thr Phe 
    130                 135                 140                 


Ser Asp Pro Gly Gln Val Ile Thr Glu Leu Glu Gly Val Val Tyr Phe 
145                 150                 155                 160 


Thr Leu Lys Leu Ser Glu Gln Phe Thr Glu Ser Ala Thr Pro Gly Gln 
                165                 170                 175     


His Thr Phe Asp Phe Glu Thr Ser Asp Gln Val Tyr Ser Pro Ser Val 
            180                 185                 190         


Asp Leu Val Ala Leu Asp Arg Thr Gln Pro Ile Lys Leu Ser Asn Ala 
        195                 200                 205             


Val Thr Gly Gly Val Glu Trp Phe Val Asp Ile Pro Gly Ala Phe Gly 
    210                 215                 220                 


Asp Ile Thr Asn Ile Asp Ile Ser Thr Val Gln Thr Pro Gly Thr Phe 
225                 230                 235                 240 


Asp Cys Ser Glu Val Lys Tyr Ala Val Gly Ser Ser Leu Asn Glu Phe 
                245                 250                 255     


Gly Asp Phe Thr Pro Gln Asp Arg Thr Thr Phe Phe Ser Asn Ser Ser 
            260                 265                 270         


Ser Gly Glu Trp Ile Pro Ile Thr Pro Ala Ser Gly Leu Pro Val Glu 
        275                 280                 285             


Ser Phe Glu Cys Gly Asp Gly Thr Ile Ser Leu Ser Phe Ala Gly Glu 
    290                 295                 300                 


Leu Ala Asp Asp Glu Val Leu Arg Val Ser Phe Leu Ser Asn Leu Asp 
305                 310                 315                 320 


Asp Asp Val Leu Glu Val Gln Asn Val Val Asn Val Asp Leu Thr Thr 
                325                 330                 335     


Ala Asp Ser Arg Lys Arg Ala Leu Thr Ser Phe Val Leu Asp Glu Pro 
            340                 345                 350         


Phe Tyr Arg Ala Ser Arg Thr Asp Pro Ala Ala Phe Glu Ala Phe Ala 
        355                 360                 365             


Ala Val Pro Ala Asp Gly Asp Ile Thr Thr Thr Ser Thr Ala Thr Thr 
    370                 375                 380                 


Ser Val Thr Ala Thr Val Thr Glu Thr Thr Val Thr Ser Val Cys Tyr 
385                 390                 395                 400 


Val Cys Ala Glu Thr Pro Val Thr Val Thr Tyr Thr Ala Pro Val Ile 
                405                 410                 415     


Thr Asn Pro Ile Tyr Tyr Thr Thr Lys Val His Val Cys Asn Val Cys 
            420                 425                 430         


Ala Glu Thr Pro Ile Thr Tyr Thr Val Thr Ile Pro Cys Glu Ser Asp 
        435                 440                 445             


Glu Tyr Ala Pro Ala Lys Pro Thr Gly Thr Lys Gly Glu Lys Ile Val 
    450                 455                 460                 


Thr Val Val Thr Lys Glu Gly Gly Asp Lys Tyr Thr Lys Thr Tyr Glu 
465                 470                 475                 480 


Glu Val Thr Tyr Thr Lys Thr Tyr Pro Lys Glu Gly Gly His Glu Asp 
                485                 490                 495     


His Ile Val Thr Val Thr Thr Lys Glu Gly Gly Glu Lys Val Thr Lys 
            500                 505                 510         


Thr Tyr Glu Glu Val Thr Tyr Thr Lys Gly Pro Glu Ile Val Thr Val 
        515                 520                 525             


Val Thr Lys Glu Gly Gly Glu Glu Val Thr Lys Thr Tyr His Asp Val 
    530                 535                 540                 


Pro Glu Val Val Thr Val Val Thr Lys Glu Gly Gly Glu Lys Val Thr 
545                 550                 555                 560 


Thr Thr Tyr Pro Ala Thr Tyr Thr Glu Gly Pro Gly Ala Val Pro Thr 
                565                 570                 575     


Ser Val Ser Ala Pro Pro Lys Ala Thr Tyr Thr Val Ser Glu Ala Asp 
            580                 585                 590         


Val Asn Leu Gly Ser Arg Ser Ala Ala Val Gly Leu Leu Ala Ile Leu 
        595                 600                 605             


Pro Met Leu Phe Leu Ala Val 
    610                 615 


<210>  21
<211>  348
<212>  PRT
<213>  Komagataella pastoris

<400>  21

Met Gln Val Lys Ser Ile Val Asn Leu Leu Leu Ala Cys Ser Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Leu Glu His Ala His His Gln His Asp Lys Arg Gly 
            20                  25                  30          


Val Val Val Val Thr Lys Thr Ile Ile Val Asp Gly Ser Thr Val Glu 
        35                  40                  45              


Ala Thr Ala Ala Ala Gln Val Gln Glu His Ala Glu Thr Ile Ala Glu 
    50                  55                  60                  


Ser Thr Pro Ser Ala Val Val Ala Ser Ser Ala Ala Pro Ser Ala Ala 
65                  70                  75                  80  


Ser Ser Ala Ser Ala Pro Ala Ser Ser Gly Ser Phe Ser Ala Gly Thr 
                85                  90                  95      


Lys Gly Val Thr Tyr Ser Pro Tyr Gln Ala Gly Gly Gly Cys Lys Thr 
            100                 105                 110         


Ala Glu Glu Val Ala Ser Asp Leu Ser Gln Leu Thr Asp Tyr Glu Ile 
        115                 120                 125             


Ile Arg Leu Tyr Gly Val Asp Cys Asn Gln Val Glu Asn Val Phe Lys 
    130                 135                 140                 


Ala Lys Ala Pro Gly Gln Lys Leu Phe Leu Gly Ile Phe Phe Val Asp 
145                 150                 155                 160 


Ala Ile Glu Ser Gly Val Ser Ala Ile Ala Ser Ala Val Ser Ser Tyr 
                165                 170                 175     


Gly Ser Trp Asn Asp Val His Thr Val Ser Val Gly Asn Glu Leu Val 
            180                 185                 190         


Asn Asn Gly Glu Ala Thr Val Ser Gln Ile Gly Gln Tyr Val Ser Thr 
        195                 200                 205             


Ala Lys Ser Ala Leu Arg Ser Ala Gly Phe Thr Gly Pro Val Leu Ser 
    210                 215                 220                 


Val Asp Thr Phe Ile Ala Val Ile Asn Asn Pro Gly Leu Cys Asp Phe 
225                 230                 235                 240 


Ala Asp Glu Tyr Val Ala Val Asn Ala His Ala Phe Phe Asp Gly His 
                245                 250                 255     


Ile Ala Ala Ser Gly Ala Gly Asp Trp Ala Ala Glu Gln Ile Gln Arg 
            260                 265                 270         


Val Ser Ser Ala Cys Gly Gly Lys Asp Val Leu Ile Val Glu Ser Gly 
        275                 280                 285             


Trp Pro Ser Lys Gly Asp Thr Asn Gly Ala Ala Val Pro Ser Lys Ser 
    290                 295                 300                 


Asn Gln Gln Ala Ala Val Gln Ser Leu Gly Gln Lys Ile Gly Ser Ser 
305                 310                 315                 320 


Cys Ile Ala Phe Asn Ala Phe Asn Asp Tyr Trp Lys Ala Asp Gly Pro 
                325                 330                 335     


Phe Asn Ala Glu Lys Tyr Trp Gly Ile Leu Asp Ser 
            340                 345             


<210>  22
<211>  430
<212>  PRT
<213>  Komagataella pastoris

<400>  22

Met Lys Ile Ser Ala Leu Thr Ala Cys Ala Val Thr Leu Ala Gly Leu 
1               5                   10                  15      


Ala Ile Ala Ala Pro Ala Pro Lys Pro Glu Asp Cys Thr Thr Thr Val 
            20                  25                  30          


Gln Lys Arg His Gln His Lys Arg Ala Val Ala Tyr Asp Tyr Val Tyr 
        35                  40                  45              


Val Thr Val Thr Ile Asn Gly Gln Gly Glu Thr Ile Ser Pro Thr Val 
    50                  55                  60                  


Val Ala Glu Leu Glu Thr Ala Ser Thr Pro Ala Thr Ser Ser Ser Ala 
65                  70                  75                  80  


His Val Glu Thr Ser Ser Ala Pro Ala Thr Thr Ser Ser Val Pro Glu 
                85                  90                  95      


Thr Thr Ser Ala Glu Gln Thr Thr Ser Ser Ala Glu Thr Thr Ser Ala 
            100                 105                 110         


Gln Val Thr Ser Ser Val Gln Glu Thr Ser Ser Ser Ala Glu Glu Gln 
        115                 120                 125             


Val Thr Gln Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ser Ser Ser Gly Ser Ser Ser Gly Gly Ile Asp Gly Asp 
145                 150                 155                 160 


Leu Ser Trp Tyr Ser Gly Pro Gly Asn Lys Phe Gln Asp Gly Thr Ile 
                165                 170                 175     


Lys Cys Ser Glu Phe Pro Ser Gly Asn Gly Val Val Ala Leu Asp His 
            180                 185                 190         


Leu Gly Phe Gly Gly Trp Ser Gly Leu Tyr His Pro Ser Asp Thr Ser 
        195                 200                 205             


Thr Gly Gly Ile Cys Glu Pro Asp Thr Tyr Cys Ser Tyr Ala Cys Gln 
    210                 215                 220                 


Ser Gly Met Ser Lys Thr Gln Trp Pro Ser Glu Gln Pro Asp Asn Gly 
225                 230                 235                 240 


Val Ser Val Gly Gly Leu Tyr Cys Asp Ser Asp Gly Tyr Leu Tyr Arg 
                245                 250                 255     


Ser Lys Thr Asp Thr Asp Tyr Leu Cys Glu Trp Gly Ile Asp Val Ala 
            260                 265                 270         


Tyr Val Val Ser Glu Ile Gly Lys Thr Ala Ala Ile Cys Arg Thr Asp 
        275                 280                 285             


Tyr Pro Gly Thr Glu Asn Met Val Ile Pro Thr Val Val Thr Pro Gly 
    290                 295                 300                 


Gly Glu Leu Pro Leu Thr Thr Val Asp Gln Ser Ser Tyr Tyr Thr Trp 
305                 310                 315                 320 


Arg Gly Met Lys Thr Ser Ala Gln Tyr Tyr Val Asn Asp Ala Gly Val 
                325                 330                 335     


Asp Trp Thr Thr Gly Cys Thr Trp Gly Asp Tyr Gly Thr Asp Tyr Gly 
            340                 345                 350         


Asn Trp Ala Pro Leu Asn Phe Gly Ala Gly Tyr Asp Asn Gly Ile Ser 
        355                 360                 365             


Tyr Leu Ser Leu Ile Pro Asn Pro Asn Asn Lys Asp Thr Met Asn Tyr 
    370                 375                 380                 


Asn Val Lys Ile Val Ala Tyr Asp Asp Ser Ser Val Val Ile Gly Glu 
385                 390                 395                 400 


Cys Lys Tyr Glu Asn Gly Ser Tyr Asn Gly Asn Gly Ser Asp Gly Cys 
                405                 410                 415     


Thr Val Ala Val Asn Ser Gly Lys Ala Lys Phe Val Leu Tyr 
            420                 425                 430 


<210>  23
<211>  313
<212>  PRT
<213>  Komagataella pastoris

<400>  23

Met Lys Phe Ser Thr Asn Leu Ile Leu Ala Ile Ala Ala Ala Ser Thr 
1               5                   10                  15      


Val Val Ser Ala Ala Pro Val Ala Pro Ala Glu Glu Ala Ala Asn His 
            20                  25                  30          


Leu His Lys Arg Ala Tyr Tyr Thr Asp Thr Thr Lys Thr His Thr Phe 
        35                  40                  45              


Thr Glu Val Val Thr Val Tyr Arg Thr Leu Lys Pro Gly Glu Ser Ile 
    50                  55                  60                  


Pro Thr Gly Ser Pro Ser His Gly Gly Lys Gly Ser Lys Thr Gly Lys 
65                  70                  75                  80  


Gly Lys Gly Ser Thr Thr Asp Ala Gly Val Pro Gly Thr Thr Ser Val 
                85                  90                  95      


Ala Pro Thr Ala Asp Ser Thr Ser Ala Ser Gly Ser Ile Gly Leu Pro 
            100                 105                 110         


Thr Ser Ala Ser Ser Ala Thr Ser Ala Thr Ser Ser Ala Ser Thr Thr 
        115                 120                 125             


Thr Ser Gly Thr Ser Thr Ser Ser Thr Gly Thr Gly Thr Thr Thr Gly 
    130                 135                 140                 


Ala Thr Thr Gly Thr Gly Thr Ser Ser Thr Gly Thr Thr Ser Ser Ser 
145                 150                 155                 160 


Thr Ser Ser Ser Ala Thr Ser Thr Pro Thr Gly Ser Leu Asp Ala Ile 
                165                 170                 175     


Ser Gln Ser Leu Leu Asp Thr His Asn Glu Lys Arg Ala Leu His Gly 
            180                 185                 190         


Val Ser Asp Leu Thr Trp Ser Thr Glu Leu Ala Asp Tyr Ala Gln Gly 
        195                 200                 205             


Tyr Ala Asp Ser Phe Thr Cys Gly Ser Ser Leu Val His Thr Gly Gly 
    210                 215                 220                 


Pro Tyr Gly Glu Asn Leu Ala Ser Gly Tyr Ser Pro Ala Gly Ser Val 
225                 230                 235                 240 


Glu Ala Trp Tyr Asn Glu Ile Ser Asp Tyr Asp Phe Ser Asn Pro Gly 
                245                 250                 255     


Tyr Ser Ala Gly Thr Gly His Phe Thr Gln Val Val Trp Lys Ser Thr 
            260                 265                 270         


Thr Gln Leu Gly Cys Gly Tyr Lys Glu Cys Gly Thr Asn Arg Tyr Tyr 
        275                 280                 285             


Ile Ile Cys Glu Tyr Ala Pro Arg Gly Asn Ile Val Ser Ala Gly Tyr 
    290                 295                 300                 


Phe Glu Asp Asn Val Leu Pro Leu Val 
305                 310             


<210>  24
<211>  389
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Arg Phe Ser Asn Phe Leu Thr Val Ser Ala Leu Leu Thr Gly Ala 
1               5                   10                  15      


Leu Gly Ala Pro Ala Val Arg His Lys His Glu Lys Arg Asp Val Val 
            20                  25                  30          


Thr Ala Thr Val His Ala Gln Val Thr Val Val Val Ser Gly Asn Ser 
        35                  40                  45              


Gly Glu Thr Ile Val Pro Val Asn Glu Asn Ala Val Val Ala Thr Thr 
    50                  55                  60                  


Ser Ser Thr Ala Val Ala Ser Gln Ala Thr Thr Ser Thr Leu Glu Pro 
65                  70                  75                  80  


Thr Thr Ser Ala Asn Val Val Thr Ser Gln Gln Gln Thr Ser Thr Leu 
                85                  90                  95      


Gln Ser Ser Glu Ala Ala Ser Thr Val Gly Ser Ser Thr Ser Ser Ser 
            100                 105                 110         


Pro Ser Ser Ser Ser Ser Thr Ser Ser Ser Ala Ser Ser Ser Ala Ser 
        115                 120                 125             


Ser Ser Ile Ser Ala Ser Gly Ala Lys Gly Ile Thr Tyr Ser Pro Tyr 
    130                 135                 140                 


Asn Asp Asp Gly Ser Cys Lys Ser Thr Ala Gln Val Ala Ser Asp Leu 
145                 150                 155                 160 


Glu Gln Leu Thr Gly Phe Asp Asn Ile Arg Leu Tyr Gly Val Asp Cys 
                165                 170                 175     


Ser Gln Val Glu Asn Val Leu Gln Ala Lys Thr Ser Ser Gln Lys Leu 
            180                 185                 190         


Phe Leu Gly Ile Tyr Tyr Val Asp Lys Ile Gln Asp Ala Val Asp Thr 
        195                 200                 205             


Ile Lys Ser Ala Val Glu Ser Tyr Gly Ser Trp Asp Asp Ile Thr Thr 
    210                 215                 220                 


Val Ser Val Gly Asn Glu Leu Val Asn Gly Gly Ser Ala Thr Thr Thr 
225                 230                 235                 240 


Gln Val Gly Glu Tyr Val Ser Thr Ala Lys Ser Ala Leu Thr Ser Ala 
                245                 250                 255     


Gly Tyr Thr Gly Ser Val Val Ser Val Asp Thr Phe Ile Ala Val Ile 
            260                 265                 270         


Asn Asn Pro Asp Leu Cys Asn Tyr Ser Asp Tyr Met Ala Val Asn Ala 
        275                 280                 285             


His Ala Tyr Phe Asp Glu Asn Thr Ala Ala Gln Asp Ala Gly Pro Trp 
    290                 295                 300                 


Val Leu Glu Gln Ile Glu Arg Val Tyr Thr Ala Cys Gly Gly Lys Lys 
305                 310                 315                 320 


Asp Val Val Ile Thr Glu Thr Gly Trp Pro Ser Lys Gly Asp Thr Tyr 
                325                 330                 335     


Gly Glu Ala Val Pro Ser Lys Ala Asn Gln Glu Ala Ala Ile Ser Ser 
            340                 345                 350         


Ile Lys Ser Ser Cys Gly Ser Ser Ala Tyr Leu Phe Thr Ala Phe Asn 
        355                 360                 365             


Asp Leu Trp Lys Asp Asp Gly Gln Tyr Gly Val Glu Lys Tyr Trp Gly 
    370                 375                 380                 


Ile Leu Ser Ser Asp 
385                 


<210>  25
<211>  386
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Arg Leu Ser Asn Leu Ile Ala Ser Ala Ser Leu Leu Ser Ala Ala 
1               5                   10                  15      


Thr Leu Ala Ala Pro Ala Asn His Glu His Lys Asp Lys Arg Ala Val 
            20                  25                  30          


Val Thr Thr Thr Val Gln Lys Gln Thr Thr Ile Ile Val Asn Gly Ala 
        35                  40                  45              


Ala Ser Thr Pro Val Ala Ala Leu Glu Glu Asn Ala Val Val Asn Ser 
    50                  55                  60                  


Ala Pro Ala Ala Ala Thr Ser Thr Thr Ser Ser Ala Ala Ser Val Ala 
65                  70                  75                  80  


Thr Ala Ala Ala Ser Ser Ser Glu Asn Asn Ser Gln Val Ser Ala Ala 
                85                  90                  95      


Ala Ser Pro Ala Ser Ser Ser Ala Ala Thr Ser Thr Gln Ser Ser Ser 
            100                 105                 110         


Ser Ser Gln Ala Ser Ser Ser Ser Ser Ser Gly Glu Asp Val Ser Ser 
        115                 120                 125             


Phe Ala Ser Gly Val Arg Gly Ile Thr Tyr Thr Pro Tyr Glu Ser Ser 
    130                 135                 140                 


Gly Ala Cys Lys Ser Ala Ser Glu Val Ala Ser Asp Leu Ala Gln Leu 
145                 150                 155                 160 


Thr Asp Phe Pro Val Ile Arg Leu Tyr Gly Thr Asp Cys Asn Gln Val 
                165                 170                 175     


Glu Asn Val Phe Lys Ala Lys Ala Ser Asn Gln Lys Val Phe Leu Gly 
            180                 185                 190         


Ile Tyr Tyr Val Asp Gln Ile Gln Asp Gly Val Asn Thr Ile Lys Ser 
        195                 200                 205             


Ala Val Glu Ser Tyr Gly Ser Trp Asp Asp Val Thr Thr Val Ser Ile 
    210                 215                 220                 


Gly Asn Glu Leu Val Asn Gly Asn Gln Ala Thr Pro Ser Gln Val Gly 
225                 230                 235                 240 


Gln Tyr Ile Asp Ser Gly Arg Ser Ala Leu Lys Ala Ala Gly Tyr Thr 
                245                 250                 255     


Gly Pro Val Val Ser Val Asp Thr Phe Ile Ala Val Ile Asn Asn Pro 
            260                 265                 270         


Glu Leu Cys Asp Tyr Ser Asp Tyr Met Ala Val Asn Ala His Ala Tyr 
        275                 280                 285             


Phe Asp Lys Asn Thr Val Ala Gln Asp Ser Gly Lys Trp Leu Leu Glu 
    290                 295                 300                 


Gln Ile Gln Arg Val Trp Thr Ala Cys Asp Gly Lys Lys Asn Val Val 
305                 310                 315                 320 


Ile Thr Glu Ser Gly Trp Pro Ser Lys Gly Glu Thr Tyr Gly Val Ala 
                325                 330                 335     


Val Pro Ser Lys Glu Asn Gln Lys Asp Ala Val Ser Ala Ile Thr Ser 
            340                 345                 350         


Ser Cys Gly Ala Asp Thr Phe Leu Phe Thr Ala Phe Asn Asp Tyr Trp 
        355                 360                 365             


Lys Ala Asp Gly Ala Tyr Gly Val Glu Lys Tyr Trp Gly Ile Leu Ser 
    370                 375                 380                 


Asn Glu 
385     


<210>  26
<211>  420
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  26

Met Lys Leu Ser Ala Thr Thr Leu Thr Ala Ala Ser Leu Ile Gly Tyr 
1               5                   10                  15      


Ser Thr Ile Val Ser Ala Leu Pro Tyr Ala Ala Asp Ile Asp Thr Gly 
            20                  25                  30          


Cys Thr Thr Thr Ala His Gly Ser His Gln His Lys Arg Ala Val Ala 
        35                  40                  45              


Val Thr Tyr Val Tyr Glu Thr Val Thr Val Asp Lys Asn Gly Gln Thr 
    50                  55                  60                  


Val Thr Pro Thr Ser Thr Glu Ala Ser Ser Thr Val Ala Ser Thr Thr 
65                  70                  75                  80  


Thr Leu Ile Ser Glu Ser Ser Val Thr Lys Ser Ser Ser Lys Val Ala 
                85                  90                  95      


Ser Ser Ser Glu Ser Thr Glu Gln Ile Ala Thr Thr Ser Ser Ser Ala 
            100                 105                 110         


Gln Thr Thr Leu Thr Ser Ser Glu Thr Ser Thr Ser Glu Ser Ser Val 
        115                 120                 125             


Pro Ile Ser Thr Ser Gly Ser Ala Ser Thr Ser Ser Ala Ala Ser Ser 
    130                 135                 140                 


Ala Thr Gly Ser Ile Tyr Gly Asp Leu Ala Asp Phe Ser Gly Pro Tyr 
145                 150                 155                 160 


Glu Lys Phe Glu Asp Gly Thr Ile Pro Cys Gly Gln Phe Pro Ser Gly 
                165                 170                 175     


Gln Gly Val Ile Pro Ile Ser Trp Leu Asp Glu Gly Gly Trp Ser Gly 
            180                 185                 190         


Val Glu Asn Thr Asp Thr Ser Thr Gly Gly Ser Cys Lys Glu Gly Ser 
        195                 200                 205             


Tyr Cys Ser Tyr Ala Cys Gln Pro Gly Met Ser Lys Thr Gln Trp Pro 
    210                 215                 220                 


Ser Asp Gln Pro Ser Asp Gly Arg Ser Ile Gly Gly Leu Leu Cys Lys 
225                 230                 235                 240 


Asp Gly Tyr Leu Tyr Arg Ser Asn Thr Asp Thr Asp Tyr Leu Cys Glu 
                245                 250                 255     


Trp Gly Val Asp Ala Ala Tyr Val Val Ser Glu Leu Ser Asn Asp Val 
            260                 265                 270         


Ala Ile Cys Arg Thr Asp Tyr Pro Gly Thr Glu Asn Met Val Ile Pro 
        275                 280                 285             


Thr Tyr Val Gln Ala Gly Asp Ser Leu Pro Leu Thr Val Val Asp Gln 
    290                 295                 300                 


Asp Thr Tyr Tyr Thr Trp Gln Gly Leu Lys Thr Ser Ala Gln Tyr Tyr 
305                 310                 315                 320 


Val Asn Asn Ala Gly Ile Ser Val Glu Asp Ala Cys Val Trp Gly Ser 
                325                 330                 335     


Ser Ser Ser Gly Val Gly Asn Trp Ala Pro Leu Asn Phe Gly Ala Gly 
            340                 345                 350         


Ser Ser Asp Gly Val Ala Tyr Leu Ser Leu Ile Pro Asn Pro Asn Asn 
        355                 360                 365             


Gly Asn Ala Leu Asn Phe Asn Val Lys Ile Val Ala Ala Asp Asp Ser 
    370                 375                 380                 


Ser Thr Val Asn Gly Glu Cys Ile Tyr Glu Asn Gly Ser Phe Ser Gly 
385                 390                 395                 400 


Gly Ser Asp Gly Cys Thr Val Ser Val Thr Ala Gly Lys Ala Lys Phe 
                405                 410                 415     


Val Leu Tyr Asn 
            420 


<210>  27
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  27
cgcctcgaca tcatctgccc agatgc                                            26


<210>  28
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  28
cgggcgacag tcacatcatg cccctg                                            26


<210>  29
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  29
ggccagaatg taaacaaatg cagataagg                                         29


<210>  30
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
cgtcactgcc agcagtg                                                      17


<210>  31
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
gctgccttcc ctatatctga tatcac                                            26


