                         SEQUENCE LISTING

<110>  Ϻԭϸҽѧ޹˾ݼ
 
<120>  IL17弰Ӧ

<130>  0065-PA-011

<160>  139   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008/011 HCDR1

<400>  1

Asp Tyr Ala Met Ser 
1               5   


<210>  2
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008/011 HCDR2

<400>  2

Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  3
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008/011 HCDR3

<400>  3

Asp Gly Ser Asp Gly Ile Arg Tyr Phe Asp Trp Leu Phe Asn Tyr Trp 
1               5                   10                  15      


Tyr Phe Asp Leu 
            20  


<210>  4
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008/011 LCDR1

<400>  4

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008/011 LCDR2

<400>  5

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008/011 LCDR3

<400>  6

Met Gln Ala Leu Gln Thr Pro Thr 
1               5               


<210>  7
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 H-FR1

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly 
            20                  25                  30  


<210>  8
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 H-FR2

<400>  8

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  9
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 H-FR3

<400>  9

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  10
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 H-FR4

<400>  10

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  11
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 L-FR1

<400>  11

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  12
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 L-FR2

<400>  12

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  13
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 L-FR3

<400>  13

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  14
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 L-FR4

<400>  14

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  15
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008 VH

<400>  15

Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Pro Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Gly Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  16
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008 VL

<400>  16

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  17
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 VH

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Gly Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  18
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 VL

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  19
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009/012 HCDR1

<400>  19

Ser Tyr Ala Met Asn 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009/012 HCDR2

<400>  20

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009/012 HCDR3

<400>  21

Asp Gly Ser Gly Tyr Tyr Gly Gly Ser Gly Ala Phe Asp Ile 
1               5                   10                  


<210>  22
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009/012 LCDR1

<400>  22

Ser Gly Asp Asn Leu Gly Ser Lys Tyr Ala Ser 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009/012 LCDR2

<400>  23

Gln Asp Asn Lys Arg Pro Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009/012 LCDR3

<400>  24

Gln Ala Trp Asp Ser Ser Thr Tyr Val 
1               5                   


<210>  25
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 H-FR1

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  26
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 H-FR2

<400>  26

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  27
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 H-FR3

<400>  27

Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 H-FR4

<400>  28

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 L-FR1

<400>  29

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys 
            20          


<210>  30
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 L-FR2

<400>  30

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210>  31
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 L-FR3

<400>  31

Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  32
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 L-FR4

<400>  32

Phe Gly Ser Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  33
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 VH

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Gly Tyr Tyr Gly Gly Ser Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  34
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 VL

<400>  34

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile His 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Tyr Val 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105         


<210>  35
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 VH

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Gly Tyr Tyr Gly Gly Ser Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  36
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 VL

<400>  36

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Tyr Val 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105         


<210>  37
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010/013 HCDR1

<400>  37

Ser Asn His Met Ser 
1               5   


<210>  38
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010/013 HCDR2

<400>  38

Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  39
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010/013 HCDR3

<400>  39

Gly Arg Tyr Ser Gly Trp Tyr Phe Asp Tyr 
1               5                   10  


<210>  40
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010/013 LCDR1

<400>  40

Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala Ser 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010/013 LCDR2

<400>  41

Gln Asp Asp Gln Arg Pro Ser 
1               5           


<210>  42
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010/013 LCDR3

<400>  42

Gln Thr Trp Asp His Gly Thr Ser Lys Tyr Val 
1               5                   10      


<210>  43
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 H-FR1

<400>  43

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  44
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 H-FR2

<400>  44

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  45
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 H-FR3

<400>  45

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  46
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 H-FR4

<400>  46

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  47
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 L-FR1

<400>  47

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys 
            20          


<210>  48
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 L-FR2

<400>  48

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210>  49
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 L-FR3

<400>  49

Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  50
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 L-FR4

<400>  50

Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  51
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 VH

<400>  51

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Tyr Ser Gly Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  52
<211>  109
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 VL

<400>  52

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Met Arg 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Val Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp His Gly Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  53
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 VH

<400>  53

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Tyr Ser Gly Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  54
<211>  109
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 VL

<400>  54

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp His Gly Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  55
<211>  393
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008 VH ()

<400>  55
cagctgcagc tgcaggagtc tgggggaggc ttggtacagc cagggcggtc cccgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgcta tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtgcgaga      300

gatggttctg atgggatacg atattttgac tggttattca actactggta cttcgatctc      360

tggggccgtg gcaccctggt cactgtctcc tca                                   393


<210>  56
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008 VL ᣩ

<400>  56
gaaattgtga tgacacaatc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg ggtacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg      300

actttcggcg gagggaccaa gctggagatc aaacgt                                336


<210>  57
<211>  369
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 VHᣩ

<400>  57
caggtgcagc tggtacagtc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatggt      300

agtggttatt acgggggcag cggtgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210>  58
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 VLᣩ

<400>  58
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataactt ggggagtaaa tatgcttcct ggtatcaaca aaagccaggc      120

cagtcccctg tgctggtcat ccatcaagat aacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagta cttatgtctt cggatctggg      300

accaagctga ccgtcctagg t                                                321


<210>  59
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 VHᣩ

<400>  59
caggtcacct tgaaggagtc tgggggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcaa cctctgggtt caccgtcagt agcaaccaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagcg atggtaccac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtctctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agggcgatac      300

agtggctggt actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  60
<211>  327
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 VLᣩ

<400>  60
tcctatgagc tgactcagcc accctctgtg tctgtgtccc caggacagac agccacaatc       60

acctgctctg gagatgattt gggtagcaaa tatgcttcct ggtatcaaca gaggccaggc      120

cagtcccctg tcttggtcat gcgtcaggat gaccagcggc cctcagggat ccctgagcgg      180

ttctctggct ccaactctgg gaacactgcc accctgacca tcagcgggac tcaggttatg      240

gatgaggctg actattactg tcagacgtgg gaccacggca cctccaagta tgtcttcgga      300

cctgggacca agctcaccgt cctaggt                                          327


<210>  61
<211>  1383
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008  ᣩ

<400>  61
cagctgcagc tgcaggagtc tgggggaggc ttggtacagc cagggcggtc cccgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgcta tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtgcgaga      300

gatggttctg atgggatacg atattttgac tggttattca actactggta cttcgatctc      360

tggggccgtg gcaccctggt cactgtctcc tcagcgtcga ccaagggccc atcggtcttc      420

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      480

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      540

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      600

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      660

agcaacacca aggtggacaa gaaagttgag cccaaatctt gtgacaaaac tcacacatgc      720

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      780

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      840

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      900

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      960

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1020

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1080

caggtgtaca ccctgccccc atcccgggaa gagatgacca agaaccaggt cagcctgacc     1140

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1200

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1260

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1320

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1380

aaa                                                                   1383


<210>  62
<211>  461
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008 

<400>  62

Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Pro Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Gly Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  63
<211>  654
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008 ᣩ

<400>  63
gaaattgtga tgacacaatc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg ggtacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg      300

actttcggcg gagggaccaa gctggagatc aaacgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct accccagaga agccaaagtg cagtggaagg tggacaacgc cctgcagagc      480

ggaaacagcc aggaaagcgt gacagagcag gattccaagg attccacata cagcctgagc      540

agcacactga cactgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acacaccagg gactgtcctc ccctgtgaca aagagcttca acagaggaga atgc            654


<210>  64
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-008 

<400>  64

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  65
<211>  1359
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 ᣩ

<400>  65
caggtgcagc tggtacagtc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatggt      300

agtggttatt acgggggcag cggtgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcctcag cgtcgaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaagaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  66
<211>  453
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Gly Tyr Tyr Gly Gly Ser Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  67
<211>  639
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 ᣩ

<400>  67
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataactt ggggagtaaa tatgcttcct ggtatcaaca aaagccaggc      120

cagtcccctg tgctggtcat ccatcaagat aacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagta cttatgtctt cggatctggg      300

accaagctga ccgtcctagg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctacccc      420

agagaagcca aagtgcagtg gaaggtggac aacgccctgc agagcggaaa cagccaggaa      480

agcgtgacag agcaggattc caaggattcc acatacagcc tgagcagcac actgacactg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgacaca ccagggactg      600

tcctcccctg tgacaaagag cttcaacaga ggagaatgc                             639


<210>  68
<211>  213
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-009 

<400>  68

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile His 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Tyr Val 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Thr Val Leu Gly Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  69
<211>  1344
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 ᣩ

<400>  69
caggtcacct tgaaggagtc tgggggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcaa cctctgggtt caccgtcagt agcaaccaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagcg atggtaccac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtctctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agggcgatac      300

agtggctggt actttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagcgtcg      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga agagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  70
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 

<400>  70

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Tyr Ser Gly Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  71
<211>  645
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 ᣩ

<400>  71
tcctatgagc tgactcagcc accctctgtg tctgtgtccc caggacagac agccacaatc       60

acctgctctg gagatgattt gggtagcaaa tatgcttcct ggtatcaaca gaggccaggc      120

cagtcccctg tcttggtcat gcgtcaggat gaccagcggc cctcagggat ccctgagcgg      180

ttctctggct ccaactctgg gaacactgcc accctgacca tcagcgggac tcaggttatg      240

gatgaggctg actattactg tcagacgtgg gaccacggca cctccaagta tgtcttcgga      300

cctgggacca agctcaccgt cctaggtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

taccccagag aagccaaagt gcagtggaag gtggacaacg ccctgcagag cggaaacagc      480

caggaaagcg tgacagagca ggattccaag gattccacat acagcctgag cagcacactg      540

acactgtcca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacacaccag      600

ggactgtcct cccctgtgac aaagagcttc aacagaggag aatgc                      645


<210>  72
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-010 

<400>  72

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Met Arg 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Val Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp His Gly Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  73
<211>  393
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 VHᣩ

<400>  73
caggtgcagc tggtggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgcta tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtgcgaga      300

gatggttctg atgggatacg atattttgac tggttattca actactggta cttcgatctc      360

tggggccgtg gcaccctggt cactgtctcc tca                                   393


<210>  74
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 VLᣩ

<400>  74
gacattgtga tgacacaatc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg ggtacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg      300

actttcggcg gagggaccaa gctggagatc aaacgt                                336


<210>  75
<211>  1383
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 ᣩ

<400>  75
caggtgcagc tggtggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgcta tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtgcgaga      300

gatggttctg atgggatacg atattttgac tggttattca actactggta cttcgatctc      360

tggggccgtg gcaccctggt cactgtctcc tcagcgtcga ccaagggccc atcggtcttc      420

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      480

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      540

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      600

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      660

agcaacacca aggtggacaa gaaagttgag cccaaatctt gtgacaaaac tcacacatgc      720

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      780

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      840

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      900

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      960

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1020

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1080

caggtgtaca ccctgccccc atcccgggaa gagatgacca agaaccaggt cagcctgacc     1140

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1200

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1260

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1320

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1380

aaa                                                                   1383


<210>  76
<211>  461
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Gly Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  77
<211>  654
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 ᣩ

<400>  77
gacattgtga tgacacaatc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg ggtacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg      300

actttcggcg gagggaccaa gctggagatc aaacgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct accccagaga agccaaagtg cagtggaagg tggacaacgc cctgcagagc      480

ggaaacagcc aggaaagcgt gacagagcag gattccaagg attccacata cagcctgagc      540

agcacactga cactgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acacaccagg gactgtcctc ccctgtgaca aagagcttca acagaggaga atgc            654


<210>  78
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011 

<400>  78

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  79
<211>  369
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 VHᣩ

<400>  79
caggtgcagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatggt      300

agtggttatt acgggggcag cggtgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210>  80
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 VLᣩ

<400>  80
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataactt ggggagtaaa tatgcttcct ggtatcaaca aaagccaggc      120

cagtcccctg tgctggtcat ctatcaagat aacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagta cttatgtctt cggatctggg      300

accaagctga ccgtcctagg t                                                321


<210>  81
<211>  1359
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 ᣩ

<400>  81
caggtgcagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatggt      300

agtggttatt acgggggcag cggtgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcctcag cgtcgaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaagaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  82
<211>  453
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Gly Tyr Tyr Gly Gly Ser Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  83
<211>  639
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 ᣩ

<400>  83
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataactt ggggagtaaa tatgcttcct ggtatcaaca aaagccaggc      120

cagtcccctg tgctggtcat ctatcaagat aacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagta cttatgtctt cggatctggg      300

accaagctga ccgtcctagg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctacccc      420

agagaagcca aagtgcagtg gaaggtggac aacgccctgc agagcggaaa cagccaggaa      480

agcgtgacag agcaggattc caaggattcc acatacagcc tgagcagcac actgacactg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgacaca ccagggactg      600

tcctcccctg tgacaaagag cttcaacaga ggagaatgc                             639


<210>  84
<211>  213
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-012 

<400>  84

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Tyr Val 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Thr Val Leu Gly Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  85
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 VHᣩ

<400>  85
caggtcacct tgaaggagtc tgggggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaaccaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagcg atggtaccac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agggcgatac      300

agtggctggt actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  86
<211>  327
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 VLᣩ

<400>  86
tcctatgagc tgactcagcc accctctgtg tctgtgtccc caggacagac agcctcaatc       60

acctgctctg gagatgattt gggtagcaaa tatgcttcct ggtatcaaca gaagccaggc      120

cagtcccctg tcttggtcat ttaccaggat gaccagcggc cctcagggat ccctgagcgg      180

ttctctggct ccaactctgg gaacactgcc accctgacca tcagcgggac tcaggctatg      240

gatgaggctg actattactg tcagacgtgg gaccacggca cctccaagta tgtcttcgga      300

cctgggacca agctcaccgt cctaggt                                          327


<210>  87
<211>  1344
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 ᣩ

<400>  87
caggtcacct tgaaggagtc tgggggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaaccaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagcg atggtaccac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agggcgatac      300

agtggctggt actttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagcgtcg      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga agagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  88
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 

<400>  88

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Tyr Ser Gly Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  89
<211>  645
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 ᣩ

<400>  89
tcctatgagc tgactcagcc accctctgtg tctgtgtccc caggacagac agcctcaatc       60

acctgctctg gagatgattt gggtagcaaa tatgcttcct ggtatcaaca gaagccaggc      120

cagtcccctg tcttggtcat ttaccaggat gaccagcggc cctcagggat ccctgagcgg      180

ttctctggct ccaactctgg gaacactgcc accctgacca tcagcgggac tcaggctatg      240

gatgaggctg actattactg tcagacgtgg gaccacggca cctccaagta tgtcttcgga      300

cctgggacca agctcaccgt cctaggtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

taccccagag aagccaaagt gcagtggaag gtggacaacg ccctgcagag cggaaacagc      480

caggaaagcg tgacagagca ggattccaag gattccacat acagcctgag cagcacactg      540

acactgtcca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacacaccag      600

ggactgtcct cccctgtgac aaagagcttc aacagaggag aatgc                      645


<210>  90
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013 

<400>  90

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp His Gly Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  91
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067/070 HCDR1

<400>  91

Asp Tyr Ala Met Asn 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-069 HCDR1

<400>  92

Asp Tyr Ala Ile Asn 
1               5   


<210>  93
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-070 HCDR2

<400>  93

Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Thr Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  94
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067/069/070 HCDR3

<400>  94

Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu Phe Asn Tyr Trp 
1               5                   10                  15      


Tyr Phe Asp Leu 
            20  


<210>  95
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-068 HCDR3

<400>  95

Asp Gly Ser Asp Glu Ile Arg Tyr Leu Asp Trp Leu Phe Asn Tyr Trp 
1               5                   10                  15      


Tyr Phe Asp Leu 
            20  


<210>  96
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067/068/069/070 LCDR1

<400>  96

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Glu 
1               5                   10                  15      


<210>  97
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067/068/069/070 LFR1

<400>  97

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu His Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  98
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067/068/069/070 LFR2

<400>  98

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Pro 
1               5                   10          


<210>  99
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-070 HFR3

<400>  99

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Gln Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  100
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-065 HCDR3

<400>  100

Gly Gly Asn Ser Asp Trp Asn Phe Asp Tyr 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-066 HCDR3

<400>  101

Gly Arg Asn Ser Gly Phe Ser Phe Asp Tyr 
1               5                   10  


<210>  102
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-065/YN-066 LCDR3

<400>  102

Gln Thr Trp Asp Tyr Trp Thr Ser Lys Tyr Val 
1               5                   10      


<210>  103
<211>  109
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-065/YN-066 VL

<400>  103

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp Tyr Trp Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  104
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-065/YN-066 

<400>  104

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp Tyr Trp Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  105
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-065 VH

<400>  105

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Asn Ser Asp Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  106
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-065 

<400>  106

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Asn Ser Asp Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  107
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-066 VH

<400>  107

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Asn Ser Gly Phe Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  108
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-066 

<400>  108

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Asn Ser Gly Phe Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  109
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067/YN-068/YN-069/YN-070 VL

<400>  109

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu His Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Pro Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  110
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067/YN-067 Fab/YN-068/YN-068 
       Fab/YN-069/YN-069Fab/YN-070/YN-070 Fab 

<400>  110

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu His Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Pro Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  111
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067 VH

<400>  111

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  112
<211>  461
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067 

<400>  112

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  113
<211>  236
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-067 Fab 

<400>  113

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235     


<210>  114
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-068 VH

<400>  114

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Leu Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  115
<211>  461
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-068 

<400>  115

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Leu Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  116
<211>  236
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-068 Fab 

<400>  116

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Leu Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235     


<210>  117
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-069 VH

<400>  117

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Ile Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  118
<211>  461
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-069 

<400>  118

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Ile Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  119
<211>  236
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-069 Fab 

<400>  119

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Ile Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235     


<210>  120
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-070 VH

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Thr 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Gln Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  121
<211>  461
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-070 

<400>  121

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Thr 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Gln Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  122
<211>  236
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN070 Fab 

<400>  122

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Thr 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Gln Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Glu Ile Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235     


<210>  123
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 HCDR1 ͨʽ


<220>
<221>  X4
<222>  (4)..(4)
<223>  X4 = M or I

<220>
<221>  X5
<222>  (5)..(5)
<223>  X5 = S or N

<220>
<221>  X5
<222>  (5)..(5)
<223>  X5 = S  N

<400>  123

Asp Tyr Ala Xaa Xaa 
1               5   


<210>  124
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 HCDR2 ͨʽ


<220>
<221>  X15
<222>  (15)..(15)
<223>  X15 = T  A

<400>  124

Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Xaa Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  125
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 HCDR3 ͨʽ


<220>
<221>  X5
<222>  (5)..(5)
<223>  X5 = G  E

<220>
<221>  X9
<222>  (9)..(9)
<223>  X9 = F  L

<400>  125

Asp Gly Ser Asp Xaa Ile Arg Tyr Xaa Asp Trp Leu Phe Asn Tyr Trp 
1               5                   10                  15      


Tyr Phe Asp Leu 
            20  


<210>  126
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 LCDR1 ͨʽ


<220>
<221>  X16
<222>  (16)..(16)
<223>  X16 = D  E

<400>  126

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Xaa 
1               5                   10                  15      


<210>  127
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 LFR1 ͨʽ


<220>
<221>  X12
<222>  (12)..(12)
<223>  X12 = P  H

<400>  127

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Xaa Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  128
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 LFR2 ͨʽ


<220>
<221>  X12
<222>  (12)..(12)
<223>  X12 = LP

<400>  128

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Xaa Leu Ile Tyr 
1               5                   10                  15  


<210>  129
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 HFR3 ͨʽ


<220>
<221>  X23
<222>  (23)..(23)
<223>  X23 = E  Q

<400>  129

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Xaa Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  130
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013/065/YN-066 HCDR3 ͨʽ


<220>
<221>  X2
<222>  (2)..(2)
<223>  X2 = RG

<220>
<221>  X3
<222>  (3)..(3)
<223>  X3 = YN

<220>
<221>  X5
<222>  (5)..(5)
<223>  X5 = GD

<220>
<221>  X6
<222>  (6)..(6)
<223>  X6 = WF

<220>
<221>  X7
<222>  (7)..(7)
<223>  X7 = YNS

<400>  130

Gly Xaa Xaa Ser Xaa Xaa Xaa Phe Asp Tyr 
1               5                   10  


<210>  131
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013/065/YN-066 LCDR3 ͨʽ


<220>
<221>  X5
<222>  (5)..(5)
<223>  X5 = HY

<220>
<221>  X6
<222>  (6)..(6)
<223>  X6 = GW

<400>  131

Gln Thr Trp Asp Xaa Xaa Thr Ser Lys Tyr Val 
1               5                   10      


<210>  132
<211>  109
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013/065/YN-066 VLͨʽ


<220>
<221>  X92
<222>  (92)..(92)
<223>  X92 = H  Y

<220>
<221>  X93
<222>  (93)..(93)
<223>  X93 = GW

<400>  132

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp Xaa Xaa Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  133
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013/065/YN-066 VHͨʽ


<220>
<221>  X99
<222>  (99)..(99)
<223>  X99 = R  G

<220>
<221>  X100
<222>  (100)..(100)
<223>  X100 = Y  N

<220>
<221>  X102
<222>  (102)..(102)
<223>  X102 = G  D

<220>
<221>  X103
<222>  (103)..(103)
<223>  X103 =W  F

<220>
<221>  X104
<222>  (104)..(104)
<223>  X104 =Y  NS

<400>  133

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Xaa Xaa Ser Xaa Xaa Xaa Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  134
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 VLͨʽ


<220>
<221>  X12
<222>  (12)..(12)
<223>  X12 = PH

<220>
<221>  X39
<222>  (39)..(39)
<223>  X39 = DE

<220>
<221>  X51
<222>  (51)..(51)
<223>  X51 = LP

<400>  134

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Xaa Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Xaa Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Xaa Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  135
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 VHͨʽ


<220>
<221>  X34
<222>  (34)..(34)
<223>  X34=MI

<220>
<221>  X35
<222>  (35)..(35)
<223>  X35=SN

<220>
<221>  X54
<222>  (54)..(54)
<223>  X54=AT

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  X91
<222>  (91)..(91)
<223>  X91=EQ

<220>
<221>  X105
<222>  (105)..(105)
<223>  X105=GE

<220>
<221>  X109
<222>  (109)..(109)
<223>  X109=FL

<400>  135

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Xaa 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Xaa Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Xaa Ile Arg Tyr Xaa Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  136
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013/065/YN-066 ͨʽ


<220>
<221>  92
<222>  (92)..(92)
<223>  X92=HY

<220>
<221>  93
<222>  (93)..(93)
<223>  X93=GW

<400>  136

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asp Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp Xaa Xaa Thr Ser Lys 
                85                  90                  95      


Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  137
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-013/065/YN-066 ͨʽ


<220>
<221>  X99
<222>  (99)..(99)
<223>  X99=RG

<220>
<221>  X100
<222>  (100)..(100)
<223>  X100=YN

<220>
<221>  X102
<222>  (102)..(102)
<223>  X102=GD

<220>
<221>  X103
<222>  (103)..(103)
<223>  X103=WF

<220>
<221>  X104
<222>  (104)..(104)
<223>  X104=YNS

<400>  137

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Xaa Xaa Ser Xaa Xaa Xaa Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  138
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 ͨʽ


<220>
<221>  X12
<222>  (12)..(12)
<223>  X12=PH

<220>
<221>  X39
<222>  (39)..(39)
<223>  X39=DE

<220>
<221>  X51
<222>  (51)..(51)
<223>  X51=LP

<400>  138

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Xaa Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Xaa Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Xaa Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  139
<211>  461
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  YN-011/067/068/069/070 ͨʽ


<220>
<221>  X34
<222>  (34)..(34)
<223>  X34=MI

<220>
<221>  X35
<222>  (35)..(35)
<223>  X35=SN

<220>
<221>  X54
<222>  (54)..(54)
<223>  X54=AT

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  X91
<222>  (91)..(91)
<223>  X91=EQ

<220>
<221>  X105
<222>  (105)..(105)
<223>  X105=GE

<220>
<221>  X109
<222>  (109)..(109)
<223>  X109=FL

<400>  139

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Xaa 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Xaa Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Gly Ser Asp Xaa Ile Arg Tyr Xaa Asp Trp Leu 
            100                 105                 110         


Phe Asn Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


