                         б

<110>  ҩƷ޹˾
 
<120>  PD-1/VEGFȻṹԴʽ˫쿹弰Ʊ

<130>  LZ1708848CN01

<160>  22    

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  321
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  1
gacatccaga tgacccagtc cccttcctcc ctgtccgctt ccgtgggcga cagggtgacc     60

atcacctgca gcgccagcca ggacatctcc aactacctga actggtatca acagaagccc    120

ggcaaggccc ccaaggtgct gatctacttc acctcctccc tgcactccgg cgtgccttcc    180

aggttttccg gctccggctc cggcacagac ttcacactga caatctcctc cctgcagcct    240

gaggacttcg ccacctacta ctgtcagcag tactccacag tgccctggac cttcggccag    300

ggcaccaagg tggagatcaa g                                              321


<210>  2
<211>  107
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  321
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  VEGF㶨

<400>  3
cgaactgtgg ccgctccaag cgtcttcatt tttccaccct ctgacgaaca gctgaagtca     60

gggacagctt ccgtggtctg tctgctgaac aatttttacc ccagggaggc caaagtgcag    120

tggaaggtcg ataacgctct gcagagcgga aattctcagg agagtgtgac agaacaggac    180

tcaaaagatt ccacttatag cctgtctagt accctgacac tgtccaaggc agactacgaa    240

aagcataaag tgtatgcctg tgaggtcaca catcagggtc tgtcaagccc cgtcactaag    300

tccttcaatc gtggcgaatg c                                              321


<210>  4
<211>  107
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  VEGF㶨

<400>  4

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  369
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  5
gaggtgcagc tggtggagtc cggaggaggc ctggtgcagc ctggaggttc tctgaggctg     60

tcctgtgccg cctccggcta caccttcacc aactacggca tgaactgggt gaggcaggcc    120

cctggaaagg gcctggaatg ggtgggctgg atcaacacct acaccggcga gcccacctat    180

gccgccgact tcaagaggag gttcaccttc tccctcgaca cctccaagag caccgcctac    240

ctgcagatga actccctgag ggctgaggac accgccgtgt actactgcgc caagtacccc    300

cactactacg gctcctccca ttggtacttc gacgtgtggg gccagggcac cctggtgaca    360

gtgtcctcc                                                            369


<210>  6
<211>  123
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  7
<211>  321
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  7
gacatccaga tgacacagag ccctagcagc ctgtccgcca gcgtgggcga cagagtgacc     60

atcacctgca gagcctccca ggacgtgagc acagccgtcg cctggtatca acagaagccc    120

ggcaaggccc ccaagctgct gatctactcc gccagcttcc tgtactccgg cgtgcccagc    180

agattcagcg gcagcggaag cggcaccgac ttcaccctga ccatcagcag cctgcagccc    240

gaggacttcg ccacctacta ctgccagcag ggctacggca accccttcac cttcggccag    300

ggcaccaagg tggagatcaa g                                              321


<210>  8
<211>  107
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Asn Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  333
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  PD-1ɱ

<400>  9
gagatcgtgc tgacccagag ccctgccaca ctgagcctga gccctggcga aagggccacc     60

ctgagctgca gggctagcaa gggcgtgagc accagcggct acagctacct gcactggtat    120

caacagaagc ccggccaggc tcctaggctg ctgatctacc tggccagcta tctggagagc    180

ggcgtgcccg ctagattcag cggaagcggc agcggcaccg acttcaccct gaccatcagc    240

agcctggagc ccgaggactt cgccgtgtac tactgccagc acagcaggga cctgcctctg    300

accttcggag gcggcaccaa ggtggagatc aag                                 333


<210>  10
<211>  111
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  11
<211>  360
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  PD-1ɱ

<400>  11
caggtgcagc tggtgcagag cggcgtggag gtgaagaagc ctggcgccag cgtgaaggtg     60

agctgcaagg ccagcggcta caccttcacc aactactaca tgtactgggt gaggcaggcc    120

cctggccaag gactggagtg gatgggcggc atcaacccca gcaacggcgg caccaacttc    180

aacgagaagt tcaagaacag ggtgaccctg accaccgaca gcagcaccac caccgcctac    240

atggagctga agagcctgca gttcgacgac accgccgtgt actactgcgc caggagggac    300

tacaggttcg acatgggctt cgactactgg ggccagggca ccacagtgac cgtgtccagc    360


<210>  12
<211>  120
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  PD-1ɱ

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  990
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  PD-1㶨

<400>  13
gctagcacaa aaggaccttc cgtgtttcca ctggcaccct ctagtaagag tacttcagga     60

ggaaccgcag cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct    120

tggaacagtg gagcactgac ctccggggtc catacatttc ctgccgtgct gcagtcatcc    180

ggtctgtata gcctgagctc tgtggtcaca gtcccaagtt catccctggg cacccagaca    240

tacatctgca acgtgaatca caaaccttcc aatactaagg tcgacaagaa agtggaaccc    300

aagtcctgcg ataagaccca cacatgccct ccctgtcctg ctcccgaact gctgggagga    360

ccctccgtct tcctgttccc ccccaagccc aaagacacac tgatgatcag caggacccct    420

gaagtgacct gcgtggtcgt ggacgtgagc cacgaggacc ccgaggtcaa gtttaactgg    480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaagc ccagggagga gcagtacgcc    540

agcacctaca gggtcgtgtc cgtgctgacc gtgctccacc aagattggct caacggcaag    600

gagtataagt gcaaagtcag caacaaggcc ctccccgccc ccatcgagaa aaccatcagc    660

aaggccaagg gccaaccgcg ggaacctcaa gtgtataccc tccctcccag ccgggatgag    720

ctgaccaaga accaagtctc cctcttgtgc ctggtcaagg gattctaccc ttccgacatt    780

gccgtcgaat gggagagcaa tggccagccc gagaacaact acaagacaac cccccccgtc    840

ctgcgcagcg acggatcctt cttcctgtac tccaagctca ccgtggacaa gagccggtgg    900

caacagggca acgtgttctc ctgtagcgtg atgcacgaag ccctccacaa ccactatacc    960

cagaagagcc tgagcctcag ccccggcaaa                                     990


<210>  14
<211>  330
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  PD-1㶨

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Arg Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  321
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  PD-1ɱ

<400>  15
gacatcgtcc tgacccagag tcccgccacc ctgagcctga gtcccggaga aagagcaaca     60

ctgagctgcc gagccagcca gagcattagc aacaatctgc actggtacca gcagaagcca    120

ggacaggcac ctcgactgct gatcagattc gcttctcaga gtatctcagg gattccagca    180

aggttcagcg gctccgggtc tggaaccgac tttaccctga caattagctc cctggagccc    240

gaagatttcg ccgtgtattt ttgccagcag agcgataatt ggcccctgac attcggaggc    300

ggaactaaag tggaaatcaa a                                              321


<210>  16
<211>  107
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  PD-1ɱ

<400>  16

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asp Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  351
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  PD-1ɱ

<400>  17
gaggtcaatc tggtggagag cggcggcggc ctggtgcagc ctggcggcag cctgagactg     60

agttgtgcag caagcgggtt cacttttagc tcctacggaa tgagctgggt gaggcaggca    120

ccaggcaagg gactggagtg ggtcgcctct atcagtggcg ggggacgcta cacctactat    180

cctgactcca tgaagggccg gttcacaatc tcaagagata acagcaagaa caatctgtat    240

ctgcagatga attctctgcg agccgaagac accgctgtgt actattgcgt ctacgaatac    300

ttttacacta tggactactg ggggcagggc actctggtga ccgtctcctc a             351


<210>  18
<211>  117
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  PD-1ɱ

<400>  18

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Tyr Glu Tyr Phe Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  990
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  PD-1㶨

<400>  19
gctagcacaa aaggaccttc cgtgtttcca ctggcaccct ctagtaagag tacttcagga     60

ggaaccgcag cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct    120

tggaacagtg gagcactgac ctccggggtc catacatttc ctgccgtgct gcagtcatcc    180

ggtctgtata gcctgagctc tgtggtcaca gtcccaagtt catccctggg cacccagaca    240

tacatctgca acgtgaatca caaaccttcc aatactaagg tcgacaagaa agtggaaccc    300

aagtcctgcg ataagaccca cacatgccct ccctgtcctg ctcccgaact gctgggagga    360

ccctccgtct tcctgttccc ccccaagccc aaagacacac tgatgatcag caggacccct    420

gaagtgacct gcgtggtcgt ggacgtgagc cacgaggacc ccgaggtcaa gtttaactgg    480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaagc ccagggagga gcagtacgcc    540

agcacctaca gggtggtcag cgtgctgacc gtgctgcacc aggattggct caacggcaag    600

gagtacaagt gcaaagtctc caacaaggcc ctgcccgccc ccatcgagaa gaccatctcc    660

aaggctaagg gacagcccag ggagccccaa gtgtacaccg agcctcccag ccgggatgag    720

ctgaccaaga accaagtctc cctcacctgc ctggtcaagg gattctaccc ttccgacatt    780

gccgtcgaat gggagagcaa tggccagccc gagaacaact acaagacaac cccccccgtc    840

ctggatagcg acggatcctt cttcctgctc tccgtgctca ccgtcgacaa gagcagatgg    900

cagcagggca acgtgttcag ctgtagcgtg atgcacgagg ccctgcacaa ccactacacc    960

cagaagagcc tgtccctcag ccccggcaag                                     990


<210>  20
<211>  330
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  PD-1㶨

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Glu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Leu Ser Val Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  21
<211>  360
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  21
gaggtgcagc tggtggagag cggaggcgga ctggtgcaac ctggcggatc cctgagactg     60

agctgtgccg ccagcggctt caccatctcc gactactgga tccactgggt gaggcaggcc    120

cctggaaagg gcctggaatg ggtggccgga atcacccctg ccggcggcta tacctactac    180

gccgacagcg tgaagggcag gttcaccatc agcgccgaca ccagcaagaa caccgcctac    240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caggttcgtg    300

ttcttcctgc cctacgccat ggactactgg ggccagggaa ccctggtgac cgtgagcagc    360


<210>  22
<211>  120
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  VEGFɱ

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Phe Phe Leu Pro Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 




