                         SEQUENCE LISTING

<110>  IBEX BIOSCIENCES, LLC
 
<120>  USE OF PCBP1 TO TREAT HYPERPROLIFERATIVE DISEASE

<130>  IBEX-003/01WO 325614-2014

<150>  US 62/626,424
<151>  2018-02-05

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1071
<212>  DNA
<213>  Homo sapiens

<400>  1
atggatgccg gtgtgactga aagtggacta aatgtgactc tcaccattcg gcttcttatg       60

cacggaaagg aagtaggaag catcattggg aagaaagggg agtcggttaa gaggatccgc      120

gaggagagtg gcgcgcggat caacatctcg gaggggaatt gtccggagag aatcatcact      180

ctgaccggcc ccaccaatgc catctttaag gctttcgcta tgatcatcga caagctggag      240

gaagatatca acagctccat gaccaacagt accgcggcca gcaggccccc ggtcaccctg      300

aggctggtgg tgccggccac ccagtgcggc tccctgattg ggaaaggcgg gtgtaagatc      360

aaagagatcc gcgagagtac gggggcgcag gtccaggtgg cgggggatat gctgcccaac      420

tccaccgagc gggccatcac catcgctggc gtgccgcagt ctgtcaccga gtgtgtcaag      480

cagatttgcc tggtcatgct ggagacgctc tcccagtctc cgcaagggag agtcatgacc      540

attccgtacc agcccatgcc ggccagctcc ccagtcatct gcgcgggcgg ccaagatcgg      600

tgcagcgacg ctgcgggcta cccccatgcc acccatgacc tggagggacc acctctagat      660

gcctactcga ttcaaggaca acacaccatt tctccgctcg atctggccaa gctgaaccag      720

gtggcaagac aacagtctca ctttgccatg atgcacggcg ggaccggatt cgccggaatt      780

gactccagct ctccagaggt gaaaggctat tgggcaagtt tggatgcatc tactcaaacc      840

acccatgaac tcaccattcc aaataactta attggctgca taatcgggcg ccaaggcgcc      900

aacattaatg agatccgcca gatgtccggg gcccagatca aaattgccaa cccagtggaa      960

ggctcctctg gtaggcaggt tactatcact ggctctgctg ccagtattag tctggcccag     1020

tatctaatca atgccaggct ttcctctgag aagggcatgg ggtgcagcta g              1071


<210>  2
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ala Gly Val Thr Glu Ser Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Arg Ile Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Thr Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Asn Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Thr Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Val Pro Gln Ser Val Thr Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Leu Val Met Leu Glu Thr Leu Ser Gln Ser Pro Gln Gly 
                165                 170                 175     


Arg Val Met Thr Ile Pro Tyr Gln Pro Met Pro Ala Ser Ser Pro Val 
            180                 185                 190         


Ile Cys Ala Gly Gly Gln Asp Arg Cys Ser Asp Ala Ala Gly Tyr Pro 
        195                 200                 205             


His Ala Thr His Asp Leu Glu Gly Pro Pro Leu Asp Ala Tyr Ser Ile 
    210                 215                 220                 


Gln Gly Gln His Thr Ile Ser Pro Leu Asp Leu Ala Lys Leu Asn Gln 
225                 230                 235                 240 


Val Ala Arg Gln Gln Ser His Phe Ala Met Met His Gly Gly Thr Gly 
                245                 250                 255     


Phe Ala Gly Ile Asp Ser Ser Ser Pro Glu Val Lys Gly Tyr Trp Ala 
            260                 265                 270         


Ser Leu Asp Ala Ser Thr Gln Thr Thr His Glu Leu Thr Ile Pro Asn 
        275                 280                 285             


Asn Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly Ala Asn Ile Asn Glu 
    290                 295                 300                 


Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Pro Val Glu 
305                 310                 315                 320 


Gly Ser Ser Gly Arg Gln Val Thr Ile Thr Gly Ser Ala Ala Ser Ile 
                325                 330                 335     


Ser Leu Ala Gln Tyr Leu Ile Asn Ala Arg Leu Ser Ser Glu Lys Gly 
            340                 345                 350         


Met Gly Cys Ser 
        355     


<210>  3
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPCBP1_1 (c668t)

<400>  3
atggatgccg gtgtgactga aagtggacta aatgtgactc tcaccattcg gcttcttatg       60

cacggaaagg aagtaggaag catcattggg aagaaagggg agtcggttaa gaggatccgc      120

gaggagagtg gcgcgcggat caacatctcg gaggggaatt gtccggagag aatcatcact      180

ctgaccggcc ccaccaatgc catctttaag gctttcgcta tgatcatcga caagctggag      240

gaagatatca acagctccat gaccaacagt accgcggcca gcaggccccc ggtcaccctg      300

aggctggtgg tgccggccac ccagtgcggc tccctgattg ggaaaggcgg gtgtaagatc      360

aaagagatcc gcgagagtac gggggcgcag gtccaggtgg cgggggatat gctgcccaac      420

tccaccgagc gggccatcac catcgctggc gtgccgcagt ctgtcaccga gtgtgtcaag      480

cagatttgcc tggtcatgct ggagacgctc tcccagtctc cgcaagggag agtcatgacc      540

attccgtacc agcccatgcc ggccagctcc ccagtcatct gcgcgggcgg ccaagatcgg      600

tgcagcgacg ctgcgggcta cccccatgcc acccatgacc tggagggacc acctctagat      660

gcctacttga ttcaaggaca acacaccatt tctccgctcg atctggccaa gctgaaccag      720

gtggcaagac aacagtctca ctttgccatg atgcacggcg ggaccggatt cgccggaatt      780

gactccagct ctccagaggt gaaaggctat tgggcaagtt tggatgcatc tactcaaacc      840

acccatgaac tcaccattcc aaataactta attggctgca taatcgggcg ccaaggcgcc      900

aacattaatg agatccgcca gatgtccggg gcccagatca aaattgccaa cccagtggaa      960

ggctcctctg gtaggcaggt tactatcact ggctctgctg ccagtattag tctggcccag     1020

tatctaatca atgccaggct ttcctctgag aagggcatgg ggtgcagcta g              1071


<210>  4
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mPCBP1_1 (S223L)

<400>  4

Met Asp Ala Gly Val Thr Glu Ser Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Arg Ile Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Thr Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Asn Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Thr Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Val Pro Gln Ser Val Thr Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Leu Val Met Leu Glu Thr Leu Ser Gln Ser Pro Gln Gly 
                165                 170                 175     


Arg Val Met Thr Ile Pro Tyr Gln Pro Met Pro Ala Ser Ser Pro Val 
            180                 185                 190         


Ile Cys Ala Gly Gly Gln Asp Arg Cys Ser Asp Ala Ala Gly Tyr Pro 
        195                 200                 205             


His Ala Thr His Asp Leu Glu Gly Pro Pro Leu Asp Ala Tyr Leu Ile 
    210                 215                 220                 


Gln Gly Gln His Thr Ile Ser Pro Leu Asp Leu Ala Lys Leu Asn Gln 
225                 230                 235                 240 


Val Ala Arg Gln Gln Ser His Phe Ala Met Met His Gly Gly Thr Gly 
                245                 250                 255     


Phe Ala Gly Ile Asp Ser Ser Ser Pro Glu Val Lys Gly Tyr Trp Ala 
            260                 265                 270         


Ser Leu Asp Ala Ser Thr Gln Thr Thr His Glu Leu Thr Ile Pro Asn 
        275                 280                 285             


Asn Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly Ala Asn Ile Asn Glu 
    290                 295                 300                 


Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Pro Val Glu 
305                 310                 315                 320 


Gly Ser Ser Gly Arg Gln Val Thr Ile Thr Gly Ser Ala Ala Ser Ile 
                325                 330                 335     


Ser Leu Ala Gln Tyr Leu Ile Asn Ala Arg Leu Ser Ser Glu Lys Gly 
            340                 345                 350         


Met Gly Cys Ser 
        355     


<210>  5
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPCBP1_2 cDNA (a178g and a379g)

<400>  5
atggatgccg gtgtgactga aagtggacta aatgtgactc tcaccattcg gcttcttatg       60

cacggaaagg aagtaggaag catcattggg aagaaagggg agtcggttaa gaggatccgc      120

gaggagagtg gcgcgcggat caacatctcg gaggggaatt gtccggagag aatcatcgct      180

ctgaccggcc ccaccaatgc catctttaag gctttcgcta tgatcatcga caagctggag      240

gaagatatca acagctccat gaccaacagt accgcggcca gcaggccccc ggtcaccctg      300

aggctggtgg tgccggccac ccagtgcggc tccctgattg ggaaaggcgg gtgtaagatc      360

aaagagatcc gcgagagtgc gggggcgcag gtccaggtgg cgggggatat gctgcccaac      420

tccaccgagc gggccatcac catcgctggc gtgccgcagt ctgtcaccga gtgtgtcaag      480

cagatttgcc tggtcatgct ggagacgctc tcccagtctc cgcaagggag agtcatgacc      540

attccgtacc agcccatgcc ggccagctcc ccagtcatct gcgcgggcgg ccaagatcgg      600

tgcagcgacg ctgcgggcta cccccatgcc acccatgacc tggagggacc acctctagat      660

gcctactcga ttcaaggaca acacaccatt tctccgctcg atctggccaa gctgaaccag      720

gtggcaagac aacagtctca ctttgccatg atgcacggcg ggaccggatt cgccggaatt      780

gactccagct ctccagaggt gaaaggctat tgggcaagtt tggatgcatc tactcaaacc      840

acccatgaac tcaccattcc aaataactta attggctgca taatcgggcg ccaaggcgcc      900

aacattaatg agatccgcca gatgtccggg gcccagatca aaattgccaa cccagtggaa      960

ggctcctctg gtaggcaggt tactatcact ggctctgctg ccagtattag tctggcccag     1020

tatctaatca atgccaggct ttcctctgag aagggcatgg ggtgcagcta g              1071


<210>  6
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   mPCBP1_2 (T60A and T127A)

<400>  6

Met Asp Ala Gly Val Thr Glu Ser Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Arg Ile Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Ala Leu Thr Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Asn Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Thr Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Ala Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Val Pro Gln Ser Val Thr Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Leu Val Met Leu Glu Thr Leu Ser Gln Ser Pro Gln Gly 
                165                 170                 175     


Arg Val Met Thr Ile Pro Tyr Gln Pro Met Pro Ala Ser Ser Pro Val 
            180                 185                 190         


Ile Cys Ala Gly Gly Gln Asp Arg Cys Ser Asp Ala Ala Gly Tyr Pro 
        195                 200                 205             


His Ala Thr His Asp Leu Glu Gly Pro Pro Leu Asp Ala Tyr Leu Ile 
    210                 215                 220                 


Gln Gly Gln His Thr Ile Ser Pro Leu Asp Leu Ala Lys Leu Asn Gln 
225                 230                 235                 240 


Val Ala Arg Gln Gln Ser His Phe Ala Met Met His Gly Gly Thr Gly 
                245                 250                 255     


Phe Ala Gly Ile Asp Ser Ser Ser Pro Glu Val Lys Gly Tyr Trp Ala 
            260                 265                 270         


Ser Leu Asp Ala Ser Thr Gln Thr Thr His Glu Leu Thr Ile Pro Asn 
        275                 280                 285             


Asn Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly Ala Asn Ile Asn Glu 
    290                 295                 300                 


Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Pro Val Glu 
305                 310                 315                 320 


Gly Ser Ser Gly Arg Gln Val Thr Ile Thr Gly Ser Ala Ala Ser Ile 
                325                 330                 335     


Ser Leu Ala Gln Tyr Leu Ile Asn Ala Arg Leu Ser Ser Glu Lys Gly 
            340                 345                 350         


Met Gly Cys Ser 
        355     


<210>  7
<211>  63
<212>  DNA
<213>  Unknown

<220>
<223>  T2A sequence in AAV vector

<400>  7
ggaagcggag agggcagggg aagtcttcta acatgcgggg acgtggagga aaatcccggc       60

ccc                                                                     63


<210>  8
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant PCBP1 mutation region sequence

<400>  8
gcctacttga ttcaa                                                        15


<210>  9
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant PCBP1 mutation region sequence

<400>  9
atcatcgctc tg                                                           12


<210>  10
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant PCBP1 mutation region sequence

<400>  10
gagagtgcgg gggcg                                                        15


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant PCBP1 mutation region sequence

<400>  11

Ala Tyr Leu Ile Gln 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant PCBP1 mutation region sequence

<400>  12

Ile Ile Ala Leu Thr 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant PCBP1 mutation region sequence

<400>  13

Glu Ser Ala Gly Ala 
1               5   


