                         SEQUENCE LISTING

<110>  BIOVERATIV THERAPEUTICS INC.
 
<120>  USE OF LENTIVIRAL VECTOR EXPRESSING FACTOR VIII

<130>  609628: SA9-460PC

<150>  62/625,145
<151>  2018-02-01

<150>  62/671,915
<151>  2018-05-15

<150>  62/793,158
<151>  2019-01-16

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-5

<400>  1
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg     1860

cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg     1920

ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc     1980

attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag     2040

atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc     2100

atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga     2160

atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac     2220

tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc     2280

ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg     2340

cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag     2400

gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc     2460

cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg     2520

cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc     2580

caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat     2640

ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc     2700

cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac     2760

cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg     2880

gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg     2940

ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag     3000

ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg     3060

gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac     3120

taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc     3180

caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct     3240

attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg     3300

tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt     3360

tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg     3420

gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc     3480

cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac     3540

tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt     3600

ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca     3660

ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac     3720

agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt     3780

aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac     3840

tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc     3900

atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac     3960

tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga     4020

tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag     4080

aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg     4140

tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc     4200

caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac     4260

tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac     4320

cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga           4374


<210>  2
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-4

<400>  2
atgcagatcg agctgagcac gtgcttcttc ctgtgcctgc tgaggttctg cttcagcgcc       60

accaggaggt actacctggg cgccgtggag ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc caggttcccc cccagggtgc ccaagagctt ccccttcaac      180

acgagcgtgg tgtacaagaa gaccctgttc gtggagttca ccgaccatct gttcaatatc      240

gccaagccca ggcccccctg gatggggctg ctggggccca cgatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagagg      420

gagaaggagg acgacaaggt gttccccggc ggcagccaca cctacgtgtg gcaggtgctg      480

aaggagaatg ggcccatggc cagcgacccc ctgtgcctga cctactctta cctgagccac      540

gtggatctgg tgaaggacct gaacagcggc ctgatcggcg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag accaagaaca gcctgatgca ggatagggac      720

gccgccagcg ccagggcctg gcccaagatg cacaccgtga acggctacgt gaacaggtct      780

ctgcccggcc tgatcggctg ccacaggaag agcgtgtact ggcacgtgat cggcatgggg      840

accacccccg aggtgcacag catcttcctg gagggccaca cgttcctggt gaggaatcac      900

aggcaggcca gcctggagat cagcccgatc accttcctga ccgcccagac cctgctgatg      960

gacctggggc agttcctgct gttctgccat atcagctctc accagcacga cggcatggag     1020

gcctacgtga aggtggatag ctgccccgag gagccccagc tgaggatgaa gaacaacgag     1080

gaggccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gaggttcgac     1140

gacgacaata gcccgagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcatt acatcgccgc cgaggaggag gattgggact acgcccccct ggtgctggcc     1260

cccgacgaca ggtcttacaa gagccagtac ctgaacaacg ggccccagag gatcggcagg     1320

aagtacaaga aggtgaggtt catggcctac accgacgaga ccttcaagac cagggaggcg     1380

atccagcacg agagcgggat cctggggccc ctgctgtacg gcgaggtggg cgacacgctg     1440

ctgatcatct tcaagaacca ggccagcagg ccgtacaata tctaccccca cgggatcacc     1500

gacgtgaggc ccctgtactc taggaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacgggccc     1620

acgaagagcg accccaggtg cctgaccagg tactacagct ctttcgtgaa catggagagg     1680

gacctggcca gcggcctgat cgggcccctg ctgatctgct acaaggagag cgtggatcag     1740

aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttcagcgt gttcgacgag     1800

aataggtctt ggtacctgac cgagaatatc cagaggttcc tgcccaaccc cgccggcgtg     1860

cagctggagg atcccgagtt ccaggccagc aacatcatgc acagcatcaa cggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttcagcg gcgagaccgt gttcatgagc     2100

atggagaacc ccggcctgtg gatcctgggc tgccataact ccgacttcag gaataggggc     2160

atgaccgccc tgctgaaggt gagctcttgc gacaagaaca ccggcgacta ctacgaggat     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gcccaggtct     2280

ttcagccaga acccccccgt gctgaagagg caccagaggg agatcaccag gacgaccctg     2340

cagagcgacc aggaggagat cgactacgac gacacgatca gcgtggagat gaagaaggag     2400

gatttcgaca tctacgacga ggacgagaat cagagcccca ggtctttcca gaagaagacc     2460

aggcattact tcatcgccgc cgtggagagg ctgtgggact acggcatgag cagctctccc     2520

cacgtgctga ggaatagggc ccagagcggc agcgtgcccc agttcaagaa ggtggtgttc     2580

caggagttca ccgacggcag cttcacccag cccctgtaca ggggcgagct gaacgagcac     2640

ctgggcctgc tggggcccta catcagggcc gaggtggagg ataacatcat ggtgaccttc     2700

aggaatcagg ccagcaggcc ctatagcttc tatagctctc tgatcagcta cgaggaggat     2760

cagaggcagg gcgccgagcc caggaagaac ttcgtgaagc ccaacgagac caagacctac     2820

ttctggaagg tgcagcacca catggccccc acgaaggacg agttcgactg caaggcctgg     2880

gcctacttca gcgacgtgga tctggagaag gacgtgcaca gcggcctgat cgggcccctg     2940

ctggtgtgcc acaccaacac cctgaacccc gcccacggca ggcaggtgac cgtgcaggag     3000

ttcgccctgt tcttcaccat cttcgacgag accaagagct ggtacttcac cgagaatatg     3060

gagaggaatt gcagggcccc ctgcaatatc cagatggagg acccgacctt caaggagaat     3120

tacaggttcc acgccatcaa cggctacatc atggacacgc tgcccggcct ggtcatggcc     3180

caggatcaga ggatcaggtg gtatctgctg agcatgggga gcaacgagaa tatccacagc     3240

atccacttca gcggccacgt gttcaccgtg aggaagaagg aggagtacaa gatggccctg     3300

tacaatctgt accccggcgt gttcgagacc gtggagatgc tgcccagcaa ggccgggatc     3360

tggagggtgg agtgcctgat cggcgagcac ctgcacgccg gcatgagcac gctgttcctg     3420

gtgtactcta acaagtgcca gacccccctg gggatggcca gcggccacat cagggacttc     3480

cagatcaccg ccagcggcca gtacggccag tgggccccca agctggccag gctgcactat     3540

tccggaagca tcaacgcctg gagcacgaag gagcccttca gctggatcaa ggtggatctg     3600

ctggccccca tgatcatcca cgggatcaag acccagggcg ccaggcagaa gttcagctct     3660

ctgtatatca gccagttcat catcatgtac tctctggacg gcaagaagtg gcagacctac     3720

aggggcaaca gcaccggcac gctgatggtg ttcttcggca acgtggactc tagcgggatc     3780

aagcacaata tcttcaaccc ccccatcatc gccaggtaca tcaggctgca ccccacccat     3840

tactctatca ggtctaccct gaggatggag ctgatgggct gcgacctgaa cagctgcagc     3900

atgcccctgg ggatggagag caaggccatc agcgacgccc agatcaccgc cagctcttac     3960

ttcaccaaca tgttcgccac ctggagcccg agcaaggcca ggctgcacct gcagggcagg     4020

tctaacgcct ggaggcccca ggtgaacaac cccaaggagt ggctgcaggt ggatttccag     4080

aagaccatga aggtgaccgg cgtgaccacg cagggcgtga agagcctgct gaccagcatg     4140

tacgtgaagg agttcctgat cagctctagc caggacggcc accagtggac cctgttcttc     4200

cagaacggca aggtgaaggt gttccagggc aaccaggata gcttcacccc cgtggtgaac     4260

agcctggacc cccccctgct gaccaggtat ctgaggatcc acccccagag ctgggtgcac     4320

cagatcgccc tgaggatgga ggtgctgggc tgcgaggccc aggatctgta ttga           4374


<210>  3
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52

<400>  3
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc     2100

atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac     2220

agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc     2280

ttctctcaga accccccagt gctgaagagg caccagaggg agatcaccag gaccaccctg     2340

cagtctgacc aggaggagat cgactatgat gacaccatca gcgtggagat gaagaaggag     2400

gacttcgaca tctacgacga ggacgagaac cagagcccca ggagcttcca gaagaagacc     2460

aggcactact tcattgctgc tgtggagagg ctgtgggact atggcatgtc cagcagcccc     2520

catgtgctga ggaacagggc ccagtctggc agcgtgcccc agttcaagaa agtcgtgttc     2580

caggagttca ccgacggcag cttcacccag cccctgtaca gaggggagct gaacgagcac     2640

ctgggcctgc tgggccccta catcagggcc gaggtggagg acaacatcat ggtgaccttc     2700

aggaaccagg ccagcaggcc ctacagcttc tacagcagcc tgatcagcta cgaggaggac     2760

cagaggcagg gggctgagcc caggaagaac tttgtgaagc ccaatgaaac caagacctac     2820

ttctggaagg tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttct ctgacgtgga cctggagaag gacgtgcact ctggcctgat tggccccctg     2940

ctggtgtgcc acaccaacac cctgaaccct gcccatggca ggcaggtgac tgtgcaggag     3000

ttcgccctgt tcttcaccat cttcgatgaa accaagagct ggtacttcac tgagaacatg     3060

gagaggaact gcagggcccc ctgcaacatc cagatggagg accccacctt caaggagaac     3120

tacaggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct ggtcatggcc     3180

caggaccaga ggatcaggtg gtatctgctg agcatgggca gcaacgagaa catccacagc     3240

atccacttct ctggccacgt gttcactgtg aggaagaagg aggagtacaa gatggccctg     3300

tacaacctgt accctggggt gttcgaaacc gtggagatgc tgcccagcaa ggccggcatc     3360

tggagggtgg agtgcctgat tggggagcac ctgcacgccg gcatgagcac cctgttcctg     3420

gtgtacagca acaagtgcca gacccccctg ggcatggcct ctggccacat cagggacttc     3480

cagatcactg cctctggcca gtacggccag tgggccccca agctggccag gctgcactac     3540

tccggaagca tcaatgcctg gagcaccaag gagcccttca gctggatcaa agtggacctg     3600

ctggccccca tgatcatcca cggcatcaag acccaggggg ccaggcagaa gttctccagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

aggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatc gccagataca tcaggctgca ccccacccac     3840

tacagcatca ggagcaccct gaggatggag ctgatgggct gtgacctgaa cagctgcagc     3900

atgcccctgg gcatggagag caaggccatc tctgacgccc agatcactgc ctccagctac     3960

ttcaccaaca tgtttgccac ctggagcccc agcaaggcca ggctgcacct gcagggcagg     4020

agcaatgcct ggaggcccca ggtcaacaac cccaaggagt ggctgcaggt ggacttccag     4080

aagaccatga aggtgactgg ggtgaccacc cagggggtga agagcctgct gaccagcatg     4140

tacgtgaagg agttcctgat ctccagcagc caggacggcc accagtggac cctgttcttc     4200

cagaatggca aggtgaaggt gttccagggc aaccaggaca gcttcacccc tgtggtcaac     4260

agcctggacc cccccctgct gaccagatac ctgaggatcc acccccagag ctgggtgcac     4320

cagatcgccc tgaggatgga ggtgctgggc tgtgaggccc aggacctgta ctga           4374


<210>  4
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-62

<400>  4
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc     2100

atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac     2220

agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc     2280

ttctctcaga accccccagt gctgaagagg caccagaggg agatcaccag gaccaccctg     2340

cagtctgacc aggaggagat cgactatgat gacaccatca gcgtggagat gaagaaggag     2400

gacttcgaca tctacgacga ggacgagaac cagagcccca ggagcttcca gaagaagacc     2460

aggcactact tcattgctgc tgtggagagg ctgtgggact atggcatgtc cagcagcccc     2520

catgtgctga ggaacagggc ccagtctggc agcgtgcccc agttcaagaa agtcgtgttc     2580

caggagttca ccgacggcag cttcacccag cccctgtaca gaggggagct gaacgagcac     2640

ctgggcctgc tgggccccta catcagggcc gaggtggagg acaacatcat ggtgaccttc     2700

aggaaccagg ccagcaggcc ctacagcttc tacagcagcc tgatcagcta cgaggaggac     2760

cagaggcagg gggctgagcc caggaagaac tttgtgaagc ccaatgaaac caagacctac     2820

ttctggaagg tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttct ctgacgtgga cctggagaag gacgtgcact ctggcctgat tggccccctg     2940

ctggtgtgcc acaccaacac cctgaaccct gcccatggca ggcaggtgac tgtgcaggag     3000

ttcgccctgt tcttcaccat cttcgatgaa accaagagct ggtacttcac tgagaacatg     3060

gagaggaact gcagggcccc ctgcaacatc cagatggagg accccacctt caaggagaac     3120

tacaggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct ggtcatggcc     3180

caggaccaga ggatcaggtg gtatctgctg agcatgggca gcaacgagaa catccacagc     3240

atccacttct ctggccacgt gttcactgtg aggaagaagg aggagtacaa gatggccctg     3300

tacaacctgt accctggggt gttcgaaacc gtggagatgc tgcccagcaa ggccggcatc     3360

tggagggtgg agtgcctgat tggggagcac ctgcacgccg gcatgagcac cctgttcctg     3420

gtgtacagca acaagtgcca gacccccctg ggcatggcct ctggccacat cagggacttc     3480

cagatcactg cctctggcca gtacggccag tgggccccca agctggccag gctgcactac     3540

tccggaagca tcaatgcctg gagcaccaag gagcccttca gctggatcaa agtggacctg     3600

ctggccccca tgatcatcca cggcatcaag acccaggggg ccaggcagaa gttctccagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

aggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatc gccagataca tcaggctgca ccccacccac     3840

tacagcatca ggagcaccct gaggatggag ctgatgggct gtgacctgaa cagctgcagc     3900

atgcccctgg gcatggagag caaggccatc tctgacgccc agatcactgc ctccagctac     3960

ttcaccaaca tgtttgccac ctggagcccc agcaaggcca ggctgcacct gcagggcagg     4020

agcaatgcct ggaggcccca ggtcaacaac cccaaggagt ggctgcaggt ggacttccag     4080

aagaccatga aggtgactgg ggtgaccacc cagggggtga agagcctgct gaccagcatg     4140

tacgtgaagg agttcctgat ctccagcagc caggacggcc accagtggac cctgttcttc     4200

cagaatggca aggtgaaggt gttccagggc aaccaggaca gcttcacccc tgtggtcaac     4260

agcctggacc cccccctgct gaccagatac ctgaggatcc acccccagag ctgggtgcac     4320

cagatcgccc tgaggatgga ggtgctgggc tgtgaggccc aggacctgta ctga           4374


<210>  5
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-25

<400>  5
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc       60

accaggagat actacctggg cgccgtggag ctgagctggg actacatgca gtctgacctg      120

ggcgagctgc cagtggacgc caggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa gaccctgttc gtggagttca ctgaccacct gttcaacatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtctccct gcacgccgtg      360

ggggtgagct actggaaggc ctctgagggc gccgagtacg acgaccagac cagccagagg      420

gagaaggagg acgacaaggt gttccctggg ggcagccaca cctacgtgtg gcaggtcctg      480

aaggagaacg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggac      720

gccgcctctg ccagggcctg gcccaagatg cacaccgtca acggctacgt caacaggagc      780

ctgcctggcc tgattggctg ccacaggaag agcgtgtact ggcatgtgat cggcatgggc      840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac      900

aggcaggcca gcctggagat cagccccatc accttcctga ccgcccagac cctgctgatg      960

gacctgggcc agttcctgct gttctgccac atctccagcc accagcacga cggcatggag     1020

gcctacgtga aagtggacag ctgccctgag gagccccagc tgaggatgaa gaacaacgag     1080

gaggccgagg actatgatga cgacctgacc gacagcgaga tggacgtggt caggttcgac     1140

gacgacaaca gccccagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acatcgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc     1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg     1320

aagtacaaga aagtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc     1380

atccagcatg agtctggcat cctgggcccc ctgctgtacg gggaggtggg ggacaccctg     1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcacc     1500

gacgtgaggc ccctgtacag caggaggctg cctaaggggg tgaagcacct gaaagacttc     1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggacggcccc     1620

accaagagcg accccaggtg cctgaccaga tactacagca gcttcgtcaa catggagagg     1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag     1740

aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttctctgt cttcgacgag     1800

aacaggagct ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg     1860

cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg     1920

ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc     1980

attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag     2040

atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc     2100

atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga     2160

atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac     2220

tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc     2280

ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg     2340

cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag     2400

gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc     2460

cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg     2520

cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc     2580

caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat     2640

ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc     2700

cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac     2760

cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg     2880

gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg     2940

ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag     3000

ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg     3060

gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac     3120

taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc     3180

caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct     3240

attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg     3300

tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt     3360

tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg     3420

gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc     3480

cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac     3540

tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt     3600

ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca     3660

ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac     3720

agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt     3780

aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac     3840

tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc     3900

atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac     3960

tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga     4020

tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag     4080

aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg     4140

tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc     4200

caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac     4260

tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac     4320

cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga           4374


<210>  6
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-26

<400>  6
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc       60

accaggagat actacctggg cgccgtggag ctgagctggg actacatgca gtctgacctg      120

ggcgagctgc cagtggacgc caggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa gaccctgttc gtggagttca ctgaccacct gttcaacatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtctccct gcacgccgtg      360

ggggtgagct actggaaggc ctctgagggc gccgagtacg acgaccagac cagccagagg      420

gagaaggagg acgacaaggt gttccctggg ggcagccaca cctacgtgtg gcaggtcctg      480

aaggagaacg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggac      720

gccgcctctg ccagggcctg gcccaagatg cacaccgtca acggctacgt caacaggagc      780

ctgcctggcc tgattggctg ccacaggaag agcgtgtact ggcatgtgat cggcatgggc      840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac      900

aggcaggcca gcctggagat cagccccatc accttcctga ccgcccagac cctgctgatg      960

gacctgggcc agttcctgct gttctgccac atctccagcc accagcacga cggcatggag     1020

gcctacgtga aagtggacag ctgccctgag gagccccagc tgaggatgaa gaacaacgag     1080

gaggccgagg actatgatga cgacctgacc gacagcgaga tggacgtggt caggttcgac     1140

gacgacaaca gccccagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acatcgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc     1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg     1320

aagtacaaga aagtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc     1380

atccagcatg agtctggcat cctgggcccc ctgctgtacg gggaggtggg ggacaccctg     1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcacc     1500

gacgtgaggc ccctgtacag caggaggctg cctaaggggg tgaagcacct gaaagacttc     1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggacggcccc     1620

accaagagcg accccaggtg cctgaccaga tactacagca gcttcgtcaa catggagagg     1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag     1740

aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttctctgt cttcgacgag     1800

aacaggagct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc     2340

caatcggatc aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa     2400

gatttcgata tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact     2460

agacactact ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct     2520

cacgtccttc ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc     2580

caggagttca ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac     2640

ctgggcctgc tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc     2700

cgtaaccaag catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac     2760

cagcgccaag gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac     2820

ttctggaagg tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg     2880

gcctacttct ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg     2940

ctcgtgtgtc acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag     3000

tttgctctgt tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg     3060

gagcgaaact gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac     3120

tatagattcc acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc     3180

caggatcaga ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc     3240

attcacttct ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg     3300

tacaatctgt accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc     3360

tggagagtgg agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg     3420

gtgtactcga ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc     3480

cagatcacag caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac     3540

tccggatcga tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc     3600

ctggccccta tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc     3660

ctgtacatct cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac     3720

aggggaaact ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt     3780

aagcacaaca tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac     3840

tactcaatcc gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc     3900

atgccgttgg ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac     3960

ttcactaaca tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg     4020

tcaaatgcct ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa     4080

aagaccatga aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg     4140

tatgtgaagg agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc     4200

caaaacggaa aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac     4260

tccctggacc ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat     4320

cagattgcat tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctga           4374


<210>  7
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52-NT58

<400>  7
gcgacccgcc gatactacct gggagcagtg gagctctcct gggattacat gcagagcgac       60

cttggggagc tgcccgtgga tgccaggttc cctccccggg tgccaaagtc gtttccgttc      120

aacacctccg tggtgtacaa gaaaactctg ttcgtggagt tcaccgacca cctgttcaat      180

atcgccaagc ccagacctcc ctggatgggg ctgttgggac ctaccatcca agcggaggtg      240

tacgacactg tggtcatcac tctgaagaac atggcctcgc atcccgtgtc cctgcacgcc      300

gtgggagtgt cttactggaa agcgtccgag ggggccgaat acgacgacca gacctcgcag      360

agagaaaagg aagatgacaa ggtgttccca ggaggatcgc acacctacgt gtggcaagtg      420

ttgaaggaga acggcccaat ggcctccgac ccgctgtgcc tgacctactc gtacctgtcc      480

cacgtggacc tcgtgaagga cctcaactcg ggactgattg gagccctgct ggtctgcagg      540

gaaggctcac tggcgaaaga aaagactcag accttgcaca agttcattct gctgttcgct      600

gtgttcgacg aggggaagtc gtggcacagc gagactaaga actccctgat gcaagataga      660

gatgccgcct ccgcccgggc ctggcctaag atgcacaccg tgaacggtta cgtgaaccgc      720

tccctccctg gcctgattgg atgccaccgg aagtccgtgt actggcacgt gatcgggatg      780

gggaccaccc ccgaggtgca cagcatcttc ctggaaggtc acacatttct cgtgcgcaac      840

caccggcagg cctccctgga aatcagcccc attaccttcc tcactgccca gactctgctg      900

atggacctgg gacagttcct gctgttctgc catatctcct cccaccaaca tgacggaatg      960

gaggcatacg tgaaggtcga ttcctgccct gaggaacccc agctccgcat gaagaacaat     1020

gaggaagccg aggactacga cgacgacctg acggatagcg agatggatgt ggtccggttc     1080

gatgacgata acagcccttc cttcatccaa attcgctcgg tggcaaagaa gcaccccaag     1140

acctgggtgc attacattgc ggcggaagaa gaggactggg attatgcccc gcttgtcctc     1200

gctcctgacg accggagcta caagagccag tacctgaaca acggtccaca gaggatcggt     1260

agaaagtaca agaaggtccg cttcatggcc tataccgacg aaaccttcaa aactagagag     1320

gccatccaac acgaatccgg catcctgggc ccgctcttgt acggagaagt cggcgacacc     1380

cttctcatta tcttcaagaa ccaggcttcc cggccgtaca acatctatcc gcatgggatc     1440

actgacgtgc gcccactgta ctcgcggcgc ctgcccaagg gtgtcaaaca cctgaaggat     1500

tttccgatcc ttccgggaga aatcttcaag tacaagtgga ccgtgaccgt ggaagatggc     1560

ccaactaagt ctgaccctag atgcctcacc cgctactact catccttcgt caacatggag     1620

cgcgacctgg ccagcggact gatcggcccg ctgctgattt gctacaagga atcagtggac     1680

caacggggaa accagatcat gtcggataag aggaacgtca tcctcttctc cgtg           1734


<210>  8
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52-CT

<400>  8
tttgacgaaa accggtcgtg gtacctgacc gagaacatcc agaggttcct gcccaaccct       60

gctggggtgc agctggagga ccccgagttc caggccagca acatcatgca cagcatcaat      120

ggctacgtgt tcgacagcct gcagctgagc gtgtgcctgc acgaggtggc ctactggtac      180

atcctgagca tcggcgccca gaccgacttc ctgagcgtgt tcttctctgg ctacaccttc      240

aagcacaaga tggtgtatga ggacaccctg accctgttcc ccttcagcgg ggagactgtc      300

ttcatgagca tggagaaccc tggcctgtgg atcctgggct gccacaacag cgacttcagg      360

aacaggggca tgactgccct gctgaaagtc tccagctgtg acaagaacac cggggactac      420

tacgaggaca gctacgagga catcagcgcc tacctgctga gcaagaacaa tgccatcgag      480

cccaggagct tctctcagaa ccccccagtg ctgaagaggc accagaggga gatcaccagg      540

accaccctgc agtctgacca ggaggagatc gactatgatg acaccatcag cgtggagatg      600

aagaaggagg acttcgacat ctacgacgag gacgagaacc agagccccag gagcttccag      660

aagaagacca ggcactactt cattgctgct gtggagaggc tgtgggacta tggcatgtcc      720

agcagccccc atgtgctgag gaacagggcc cagtctggca gcgtgcccca gttcaagaaa      780

gtcgtgttcc aggagttcac cgacggcagc ttcacccagc ccctgtacag aggggagctg      840

aacgagcacc tgggcctgct gggcccctac atcagggccg aggtggagga caacatcatg      900

gtgaccttca ggaaccaggc cagcaggccc tacagcttct acagcagcct gatcagctac      960

gaggaggacc agaggcaggg ggctgagccc aggaagaact ttgtgaagcc caatgaaacc     1020

aagacctact tctggaaggt gcagcaccac atggccccca ccaaggacga gttcgactgc     1080

aaggcctggg cctacttctc tgacgtggac ctggagaagg acgtgcactc tggcctgatt     1140

ggccccctgc tggtgtgcca caccaacacc ctgaaccctg cccatggcag gcaggtgact     1200

gtgcaggagt tcgccctgtt cttcaccatc ttcgatgaaa ccaagagctg gtacttcact     1260

gagaacatgg agaggaactg cagggccccc tgcaacatcc agatggagga ccccaccttc     1320

aaggagaact acaggttcca tgccatcaat ggctacatca tggacaccct gcctggcctg     1380

gtcatggccc aggaccagag gatcaggtgg tatctgctga gcatgggcag caacgagaac     1440

atccacagca tccacttctc tggccacgtg ttcactgtga ggaagaagga ggagtacaag     1500

atggccctgt acaacctgta ccctggggtg ttcgaaaccg tggagatgct gcccagcaag     1560

gccggcatct ggagggtgga gtgcctgatt ggggagcacc tgcacgccgg catgagcacc     1620

ctgttcctgg tgtacagcaa caagtgccag acccccctgg gcatggcctc tggccacatc     1680

agggacttcc agatcactgc ctctggccag tacggccagt gggcccccaa gctggccagg     1740

ctgcactact ccggaagcat caatgcctgg agcaccaagg agcccttcag ctggatcaaa     1800

gtggacctgc tggcccccat gatcatccac ggcatcaaga cccagggggc caggcagaag     1860

ttctccagcc tgtacatcag ccagttcatc atcatgtaca gcctggacgg caagaagtgg     1920

cagacctaca ggggcaacag caccggcacc ctgatggtgt tcttcggcaa cgtggacagc     1980

agcggcatca agcacaacat cttcaacccc cccatcatcg ccagatacat caggctgcac     2040

cccacccact acagcatcag gagcaccctg aggatggagc tgatgggctg tgacctgaac     2100

agctgcagca tgcccctggg catggagagc aaggccatct ctgacgccca gatcactgcc     2160

tccagctact tcaccaacat gtttgccacc tggagcccca gcaaggccag gctgcacctg     2220

cagggcagga gcaatgcctg gaggccccag gtcaacaacc ccaaggagtg gctgcaggtg     2280

gacttccaga agaccatgaa ggtgactggg gtgaccaccc agggggtgaa gagcctgctg     2340

accagcatgt acgtgaagga gttcctgatc tccagcagcc aggacggcca ccagtggacc     2400

ctgttcttcc agaatggcaa ggtgaaggtg ttccagggca accaggacag cttcacccct     2460

gtggtcaaca gcctggaccc ccccctgctg accagatacc tgaggatcca cccccagagc     2520

tgggtgcacc agatcgccct gaggatggag gtgctgggct gtgaggccca ggacctgtac     2580

tga                                                                   2583


<210>  9
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-62-NT58

<400>  9
gccactcgcc ggtactacct tggagccgtg gagctttcat gggactacat gcagagcgac       60

ctgggcgaac tccccgtgga tgccagattc cccccccgcg tgccaaagtc cttccccttt      120

aacacctccg tggtgtacaa gaaaaccctc tttgtcgagt tcactgacca cctgttcaac      180

atcgccaagc cgcgcccacc ttggatgggc ctcctgggac cgaccattca agctgaagtg      240

tacgacaccg tggtgatcac cctgaagaac atggcgtccc accccgtgtc cctgcatgcg      300

gtcggagtgt cctactggaa ggcctccgaa ggagctgagt acgacgacca gactagccag      360

cgggaaaagg aggacgataa agtgttcccg ggcggctcgc atacttacgt gtggcaagtc      420

ctgaaggaaa acggacctat ggcatccgat cctctgtgcc tgacttactc ctacctttcc      480

catgtggacc tcgtgaagga cctgaacagc gggctgattg gtgcacttct cgtgtgccgc      540

gaaggttcgc tcgctaagga aaagacccag accctccata agttcatcct tttgttcgct      600

gtgttcgatg aaggaaagtc atggcattcc gaaactaaga actcgctgat gcaggaccgg      660

gatgccgcct cagcccgcgc ctggcctaaa atgcatacag tcaacggata cgtgaatcgg      720

tcactgcccg ggctcatcgg ttgtcacaga aagtccgtgt actggcacgt catcggcatg      780

ggcactacgc ctgaagtgca ctccatcttc ctggaagggc acaccttcct cgtgcgcaac      840

caccgccagg cctctctgga aatctccccg attacctttc tgaccgccca gactctgctc      900

atggacctgg ggcagttcct tctcttctgc cacatctcca gccatcagca cgacggaatg      960

gaggcctacg tgaaggtgga ctcatgcccg gaagaacctc agttgcggat gaagaacaac     1020

gaggaggccg aggactatga cgacgatttg actgactccg agatggacgt cgtgcggttc     1080

gatgacgaca acagccccag cttcatccag attcgcagcg tggccaagaa gcaccccaaa     1140

acctgggtgc actacatcgc ggccgaggaa gaagattggg actacgcccc gttggtgctg     1200

gcacccgatg accggtcgta caagtcccag tatctgaaca atggtccgca gcggattggc     1260

agaaagtaca agaaagtgcg gttcatggcg tacactgacg aaacgtttaa gacccgggag     1320

gccattcaac atgagagcgg cattctggga ccactgctgt acggagaggt cggcgatacc     1380

ctgctcatca tcttcaaaaa ccaggcctcc cggccttaca acatctaccc tcacggaatc     1440

accgacgtgc ggccactcta ctcgcggcgc ctgccgaagg gcgtcaagca cctgaaagac     1500

ttccctatcc tgccgggcga aatcttcaag tataagtgga ccgtcaccgt ggaggacggg     1560

cccaccaaga gcgatcctag gtgtctgact cggtactact ccagcttcgt gaacatggaa     1620

cgggacctgg catcgggact cattggaccg ctgctgatct gctacaaaga gtcggtggat     1680

caacgcggca accagatcat gtccgacaag cgcaacgtga tcctgttctc cgtg           1734


<210>  10
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-62-CT

<400>  10
tttgatgaaa acagatcctg gtacctgacc gagaacatcc agaggttcct gcccaaccct       60

gctggggtgc agctggagga ccccgagttc caggccagca acatcatgca cagcatcaat      120

ggctacgtgt tcgacagcct gcagctgagc gtgtgcctgc acgaggtggc ctactggtac      180

atcctgagca tcggcgccca gaccgacttc ctgagcgtgt tcttctctgg ctacaccttc      240

aagcacaaga tggtgtatga ggacaccctg accctgttcc ccttcagcgg ggagactgtc      300

ttcatgagca tggagaaccc tggcctgtgg atcctgggct gccacaacag cgacttcagg      360

aacaggggca tgactgccct gctgaaagtc tccagctgtg acaagaacac cggggactac      420

tacgaggaca gctacgagga catcagcgcc tacctgctga gcaagaacaa tgccatcgag      480

cccaggagct tctctcagaa ccccccagtg ctgaagaggc accagaggga gatcaccagg      540

accaccctgc agtctgacca ggaggagatc gactatgatg acaccatcag cgtggagatg      600

aagaaggagg acttcgacat ctacgacgag gacgagaacc agagccccag gagcttccag      660

aagaagacca ggcactactt cattgctgct gtggagaggc tgtgggacta tggcatgtcc      720

agcagccccc atgtgctgag gaacagggcc cagtctggca gcgtgcccca gttcaagaaa      780

gtcgtgttcc aggagttcac cgacggcagc ttcacccagc ccctgtacag aggggagctg      840

aacgagcacc tgggcctgct gggcccctac atcagggccg aggtggagga caacatcatg      900

gtgaccttca ggaaccaggc cagcaggccc tacagcttct acagcagcct gatcagctac      960

gaggaggacc agaggcaggg ggctgagccc aggaagaact ttgtgaagcc caatgaaacc     1020

aagacctact tctggaaggt gcagcaccac atggccccca ccaaggacga gttcgactgc     1080

aaggcctggg cctacttctc tgacgtggac ctggagaagg acgtgcactc tggcctgatt     1140

ggccccctgc tggtgtgcca caccaacacc ctgaaccctg cccatggcag gcaggtgact     1200

gtgcaggagt tcgccctgtt cttcaccatc ttcgatgaaa ccaagagctg gtacttcact     1260

gagaacatgg agaggaactg cagggccccc tgcaacatcc agatggagga ccccaccttc     1320

aaggagaact acaggttcca tgccatcaat ggctacatca tggacaccct gcctggcctg     1380

gtcatggccc aggaccagag gatcaggtgg tatctgctga gcatgggcag caacgagaac     1440

atccacagca tccacttctc tggccacgtg ttcactgtga ggaagaagga ggagtacaag     1500

atggccctgt acaacctgta ccctggggtg ttcgaaaccg tggagatgct gcccagcaag     1560

gccggcatct ggagggtgga gtgcctgatt ggggagcacc tgcacgccgg catgagcacc     1620

ctgttcctgg tgtacagcaa caagtgccag acccccctgg gcatggcctc tggccacatc     1680

agggacttcc agatcactgc ctctggccag tacggccagt gggcccccaa gctggccagg     1740

ctgcactact ccggaagcat caatgcctgg agcaccaagg agcccttcag ctggatcaaa     1800

gtggacctgc tggcccccat gatcatccac ggcatcaaga cccagggggc caggcagaag     1860

ttctccagcc tgtacatcag ccagttcatc atcatgtaca gcctggacgg caagaagtgg     1920

cagacctaca ggggcaacag caccggcacc ctgatggtgt tcttcggcaa cgtggacagc     1980

agcggcatca agcacaacat cttcaacccc cccatcatcg ccagatacat caggctgcac     2040

cccacccact acagcatcag gagcaccctg aggatggagc tgatgggctg tgacctgaac     2100

agctgcagca tgcccctggg catggagagc aaggccatct ctgacgccca gatcactgcc     2160

tccagctact tcaccaacat gtttgccacc tggagcccca gcaaggccag gctgcacctg     2220

cagggcagga gcaatgcctg gaggccccag gtcaacaacc ccaaggagtg gctgcaggtg     2280

gacttccaga agaccatgaa ggtgactggg gtgaccaccc agggggtgaa gagcctgctg     2340

accagcatgt acgtgaagga gttcctgatc tccagcagcc aggacggcca ccagtggacc     2400

ctgttcttcc agaatggcaa ggtgaaggtg ttccagggca accaggacag cttcacccct     2460

gtggtcaaca gcctggaccc ccccctgctg accagatacc tgaggatcca cccccagagc     2520

tgggtgcacc agatcgccct gaggatggag gtgctgggct gtgaggccca ggacctgtac     2580

tga                                                                   2583


<210>  11
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-25-NT58

<400>  11
gccaccagga gatactacct gggcgccgtg gagctgagct gggactacat gcagtctgac       60

ctgggcgagc tgccagtgga cgccaggttc ccccccagag tgcccaagag cttccccttc      120

aacaccagcg tggtgtacaa gaagaccctg ttcgtggagt tcactgacca cctgttcaac      180

atcgccaagc ccaggccccc ctggatgggc ctgctgggcc ccaccatcca ggccgaggtg      240

tacgacaccg tggtcatcac cctgaagaac atggccagcc accccgtctc cctgcacgcc      300

gtgggggtga gctactggaa ggcctctgag ggcgccgagt acgacgacca gaccagccag      360

agggagaagg aggacgacaa ggtgttccct gggggcagcc acacctacgt gtggcaggtc      420

ctgaaggaga acggccccat ggcctctgac cccctgtgcc tgacctacag ctacctgagc      480

cacgtggacc tggtgaagga cctgaactct ggcctgattg gggccctgct ggtgtgcagg      540

gagggcagcc tggccaagga gaagacccag accctgcaca agttcatcct gctgttcgcc      600

gtgttcgacg agggcaagag ctggcactct gaaaccaaga acagcctgat gcaggacagg      660

gacgccgcct ctgccagggc ctggcccaag atgcacaccg tcaacggcta cgtcaacagg      720

agcctgcctg gcctgattgg ctgccacagg aagagcgtgt actggcatgt gatcggcatg      780

ggcaccaccc ctgaggtgca cagcatcttc ctggagggcc acaccttcct ggtcaggaac      840

cacaggcagg ccagcctgga gatcagcccc atcaccttcc tgaccgccca gaccctgctg      900

atggacctgg gccagttcct gctgttctgc cacatctcca gccaccagca cgacggcatg      960

gaggcctacg tgaaagtgga cagctgccct gaggagcccc agctgaggat gaagaacaac     1020

gaggaggccg aggactatga tgacgacctg accgacagcg agatggacgt ggtcaggttc     1080

gacgacgaca acagccccag cttcatccag atcaggagcg tggccaagaa gcaccccaag     1140

acctgggtgc actacatcgc tgctgaggag gaggactggg actatgcccc cctggtgctg     1200

gcccctgatg acaggagcta caagagccag tacctgaaca atggccccca gaggattggc     1260

aggaagtaca agaaagtcag gttcatggcc tacactgatg aaaccttcaa gaccagggag     1320

gccatccagc atgagtctgg catcctgggc cccctgctgt acggggaggt gggggacacc     1380

ctgctgatca tcttcaagaa ccaggccagc aggccctaca acatctaccc ccatggcatc     1440

accgacgtga ggcccctgta cagcaggagg ctgcctaagg gggtgaagca cctgaaagac     1500

ttccccatcc tgcctgggga gatcttcaag tacaagtgga ctgtgactgt ggaggacggc     1560

cccaccaaga gcgaccccag gtgcctgacc agatactaca gcagcttcgt caacatggag     1620

agggacctgg cctctggcct gattggcccc ctgctgatct gctacaagga gtctgtggac     1680

cagaggggca accagatcat gagcgacaag aggaacgtga tcctgttctc tgtc           1734


<210>  12
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-25-CT

<400>  12
ttcgacgaga acaggagctg gtacctgact gaaaacatcc agcggttcct ccccaacccc       60

gcgggcgtgc agctggaaga tcctgagttt caggcatcaa acatcatgca ctccattaac      120

ggctacgtgt tcgattcgct gcagctgagc gtgtgtctgc acgaagtggc ctactggtac      180

atcctgtcca ttggtgccca gactgacttc ctgtccgtgt ttttctccgg ctacacgttc      240

aagcacaaga tggtgtacga ggacaccctg accctcttcc ctttttccgg cgaaactgtg      300

tttatgagca tggagaatcc cggcctgtgg atcttgggct gccacaacag cgacttccgt      360

aacagaggaa tgactgcgct gctcaaggtg tccagctgcg acaagaacac cggagactat      420

tatgaggact catacgagga catctccgcc tacctcctgt ccaagaataa cgccattgaa      480

cctcggagct tcagccagaa cccacccgtg cttaagagac atcaacggga gatcactagg      540

accaccctgc agtcagacca ggaggaaatc gactacgatg acaccatctc ggtcgagatg      600

aagaaggagg actttgacat ctacgacgaa gatgaaaacc agagcccgag gtcgttccaa      660

aagaaaaccc gccactactt tattgctgct gtcgagcggc tgtgggacta cggaatgtcg      720

tcctcgccgc acgtgctccg caaccgagcc cagagcggct cggtgccgca attcaagaag      780

gtcgtgttcc aggagttcac tgacgggagc ttcactcagc ctttgtaccg gggagaactc      840

aatgaacatc tcggcctcct cggaccttac atcagagcag aagtggaaga taacatcatg      900

gtcactttcc gtaaccaagc cagccgcccg tactcgttct actcctccct catttcttac      960

gaagaggacc agcggcaggg cgcagaaccg cgcaagaact tcgtgaagcc caacgaaacc     1020

aagacctact tctggaaagt gcagcatcat atggccccga ctaaggacga gtttgactgc     1080

aaagcctggg cctacttctc cgatgtggac ttggagaagg acgtccactc cggcctcatc     1140

ggtcccctgc tcgtgtgcca taccaatacc ctgaaccccg cacacggtcg ccaggtcacc     1200

gtgcaggagt tcgctctgtt cttcactatc ttcgacgaaa ctaagtcctg gtacttcacc     1260

gagaacatgg agaggaactg cagagccccc tgtaacatcc agatggagga cccgacgttc     1320

aaggaaaact accggttcca cgccattaac ggatacatca tggatacgct gccgggtctt     1380

gtgatggccc aggatcaacg gatcagatgg tacttattgt cgatgggcag caacgagaac     1440

atccactcta ttcacttctc cggtcatgtg ttcactgtgc ggaagaagga agagtacaag     1500

atggccctgt acaaccttta tcccggagtg ttcgaaactg tggaaatgct gccgtcgaag     1560

gccggcattt ggcgcgtgga gtgtttgatt ggagaacatc tccatgcggg gatgtcaacc     1620

ctgttcctgg tgtatagcaa caagtgccag actccgcttg ggatggcgtc aggacacatt     1680

agggatttcc agatcactgc gtccggccag tacggccaat gggcccctaa gctggcccgc     1740

ctgcattact ccggatccat taacgcctgg tcaaccaagg agccattctc ctggatcaag     1800

gtggaccttc tggcccccat gattatccac ggaattaaga cccagggggc ccggcagaag     1860

ttctcctcac tgtacatcag ccagttcata atcatgtact ccctggacgg aaagaagtgg     1920

caaacctaca gggggaacag caccggcaca ctgatggtct ttttcggaaa tgtggactcc     1980

tccgggatta agcataacat cttcaaccct ccgattatcg ctcggtacat tagacttcac     2040

cctacccact acagcattcg ctccaccctg cggatggaac tgatgggctg cgatctgaac     2100

tcgtgcagca tgccgttggg aatggagtcc aaagcaattt ccgacgcgca gatcaccgcc     2160

tcgtcctact ttaccaacat gttcgccacg tggtcaccgt ccaaggcccg gctgcacctc     2220

cagggaagat ccaacgcatg gcggccacag gtcaacaacc ctaaggagtg gctccaggtg     2280

gacttccaga aaaccatgaa ggtcaccgga gtcacaaccc agggagtgaa gtcgctgctg     2340

acttctatgt acgtcaagga gttcctgatc tccagcagcc aggacgggca ccagtggacc     2400

ctgttcttcc aaaatggaaa ggtcaaggtg tttcagggca atcaggattc attcaccccg     2460

gtggtgaact cccttgatcc acccctcctg acccgctacc ttcgcatcca cccacagtcc     2520

tgggtgcacc agatcgcgct gaggatggag gtcctgggat gcgaagccca ggacctgtac     2580

tga                                                                   2583


<210>  13
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-26-NT58

<400>  13
gccaccagga gatactacct gggcgccgtg gagctgagct gggactacat gcagtctgac       60

ctgggcgagc tgccagtgga cgccaggttc ccccccagag tgcccaagag cttccccttc      120

aacaccagcg tggtgtacaa gaagaccctg ttcgtggagt tcactgacca cctgttcaac      180

atcgccaagc ccaggccccc ctggatgggc ctgctgggcc ccaccatcca ggccgaggtg      240

tacgacaccg tggtcatcac cctgaagaac atggccagcc accccgtctc cctgcacgcc      300

gtgggggtga gctactggaa ggcctctgag ggcgccgagt acgacgacca gaccagccag      360

agggagaagg aggacgacaa ggtgttccct gggggcagcc acacctacgt gtggcaggtc      420

ctgaaggaga acggccccat ggcctctgac cccctgtgcc tgacctacag ctacctgagc      480

cacgtggacc tggtgaagga cctgaactct ggcctgattg gggccctgct ggtgtgcagg      540

gagggcagcc tggccaagga gaagacccag accctgcaca agttcatcct gctgttcgcc      600

gtgttcgacg agggcaagag ctggcactct gaaaccaaga acagcctgat gcaggacagg      660

gacgccgcct ctgccagggc ctggcccaag atgcacaccg tcaacggcta cgtcaacagg      720

agcctgcctg gcctgattgg ctgccacagg aagagcgtgt actggcatgt gatcggcatg      780

ggcaccaccc ctgaggtgca cagcatcttc ctggagggcc acaccttcct ggtcaggaac      840

cacaggcagg ccagcctgga gatcagcccc atcaccttcc tgaccgccca gaccctgctg      900

atggacctgg gccagttcct gctgttctgc cacatctcca gccaccagca cgacggcatg      960

gaggcctacg tgaaagtgga cagctgccct gaggagcccc agctgaggat gaagaacaac     1020

gaggaggccg aggactatga tgacgacctg accgacagcg agatggacgt ggtcaggttc     1080

gacgacgaca acagccccag cttcatccag atcaggagcg tggccaagaa gcaccccaag     1140

acctgggtgc actacatcgc tgctgaggag gaggactggg actatgcccc cctggtgctg     1200

gcccctgatg acaggagcta caagagccag tacctgaaca atggccccca gaggattggc     1260

aggaagtaca agaaagtcag gttcatggcc tacactgatg aaaccttcaa gaccagggag     1320

gccatccagc atgagtctgg catcctgggc cccctgctgt acggggaggt gggggacacc     1380

ctgctgatca tcttcaagaa ccaggccagc aggccctaca acatctaccc ccatggcatc     1440

accgacgtga ggcccctgta cagcaggagg ctgcctaagg gggtgaagca cctgaaagac     1500

ttccccatcc tgcctgggga gatcttcaag tacaagtgga ctgtgactgt ggaggacggc     1560

cccaccaaga gcgaccccag gtgcctgacc agatactaca gcagcttcgt caacatggag     1620

agggacctgg cctctggcct gattggcccc ctgctgatct gctacaagga gtctgtggac     1680

cagaggggca accagatcat gagcgacaag aggaacgtga tcctgttctc tgtc           1734


<210>  14
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-26-CT

<400>  14
ttcgacgaga acaggagctg gtacctcact gaaaacatcc agaggttcct cccaaacccc       60

gcaggagtgc aactggagga ccctgagttt caggcctcga atatcatgca ctcgattaac      120

ggttacgtgt tcgactcgct gcagctgagc gtgtgcctcc atgaagtcgc ttactggtac      180

attctgtcca tcggcgccca gactgacttc ctgagcgtgt tcttttccgg ttacaccttt      240

aagcacaaga tggtgtacga agataccctg accctgttcc ctttctccgg cgaaacggtg      300

ttcatgtcga tggagaaccc gggtctgtgg attctgggat gccacaacag cgactttcgg      360

aaccgcggaa tgactgccct gctgaaggtg tcctcatgcg acaagaacac cggagactac      420

tacgaggact cctacgagga tatctcagcc tacctcctgt ccaagaacaa cgcgatcgag      480

ccgcgcagct tcagccagaa cccgcctgtg ctgaagaggc accagcgaga aattacccgg      540

accaccctcc aatcggatca ggaggaaatc gactacgacg acaccatctc ggtggaaatg      600

aagaaggaag atttcgatat ctacgacgag gacgaaaatc agtcccctcg ctcattccaa      660

aagaaaacta gacactactt tatcgccgcg gtggaaagac tgtgggacta tggaatgtca      720

tccagccctc acgtccttcg gaaccgggcc cagagcggat cggtgcctca gttcaagaaa      780

gtggtgttcc aggagttcac cgacggcagc ttcacccagc cgctgtaccg gggagaactg      840

aacgaacacc tgggcctgct cggtccctac atccgcgcgg aagtggagga taacatcatg      900

gtgaccttcc gtaaccaagc atccagacct tactccttct attcctccct gatctcatac      960

gaggaggacc agcgccaagg cgccgagccc cgcaagaact tcgtcaagcc caacgagact     1020

aagacctact tctggaaggt ccaacaccat atggccccga ccaaggatga gtttgactgc     1080

aaggcctggg cctacttctc cgacgtggac cttgagaagg atgtccattc cggcctgatc     1140

gggccgctgc tcgtgtgtca caccaacacc ctgaacccag cgcatggacg ccaggtcacc     1200

gtccaggagt ttgctctgtt cttcaccatt tttgacgaaa ctaagtcctg gtacttcacc     1260

gagaatatgg agcgaaactg tagagcgccc tgcaatatcc agatggaaga tccgactttc     1320

aaggagaact atagattcca cgccatcaac gggtacatca tggatactct gccggggctg     1380

gtcatggccc aggatcagag gattcggtgg tacttgctgt caatgggatc gaacgaaaac     1440

attcactcca ttcacttctc cggtcacgtg ttcactgtgc gcaagaagga ggagtacaag     1500

atggcgctgt acaatctgta ccccggggtg ttcgaaactg tggagatgct gccgtccaag     1560

gccggcatct ggagagtgga gtgcctgatc ggagagcacc tccacgcggg gatgtccacc     1620

ctcttcctgg tgtactcgaa taagtgccag accccgctgg gcatggcctc gggccacatc     1680

agagacttcc agatcacagc aagcggacaa tacggccaat gggcgccgaa gctggcccgc     1740

ttgcactact ccggatcgat caacgcatgg tccaccaagg aaccgttctc gtggattaag     1800

gtggacctcc tggcccctat gattatccac ggaattaaga cccagggcgc caggcagaag     1860

ttctcctccc tgtacatctc gcaattcatc atcatgtaca gcctggacgg gaagaagtgg     1920

cagacttaca ggggaaactc caccggcacc ctgatggtct ttttcggcaa cgtggattcc     1980

tccggcatta agcacaacat cttcaaccca ccgatcatag ccagatatat taggctccac     2040

cccactcact actcaatccg ctcaactctt cggatggaac tcatggggtg cgacctgaac     2100

tcctgctcca tgccgttggg gatggaatca aaggctatta gcgacgccca gatcaccgcg     2160

agctcctact tcactaacat gttcgccacc tggagcccct ccaaggccag gctgcacttg     2220

cagggacggt caaatgcctg gcggccgcaa gtgaacaatc cgaaggaatg gcttcaagtg     2280

gatttccaaa agaccatgaa agtgaccgga gtcaccaccc agggagtgaa gtcccttctg     2340

acctcgatgt atgtgaagga gttcctgatt agcagcagcc aggacgggca ccagtggacc     2400

ctgttcttcc aaaacggaaa ggtcaaggtg ttccagggga accaggactc gttcacaccc     2460

gtggtgaact ccctggaccc cccactgctg acgcggtact tgaggattca tcctcagtcc     2520

tgggtccatc agattgcatt gcgaatggaa gtcctgggct gcgaggccca ggacctgtac     2580

tga                                                                   2583


<210>  15
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  16
<211>  4371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BDD-FVIII (non-optimized; "parental"), Nucleotide Sequence

<400>  16
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt     2340

cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400

gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460

cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520

catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580

caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640

ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700

agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760

cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820

ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880

gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940

ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000

tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060

gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120

tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180

caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240

attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg     3300

tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360

tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420

gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480

cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540

tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600

ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660

ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720

cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780

aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840

tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900

atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960

tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020

agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080

aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140

tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200

cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260

tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320

cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta c              4371


<210>  17
<211>  1438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDD-FVIII (non-optimized; "parental"), Amino Acid Sequence

<400>  17

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1295                 1300                 1305             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1310                 1315                 1320             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1325                 1330                 1335             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1340                 1345                 1350             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1355                 1360                 1365             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1370                 1375                 1380             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1385                 1390                 1395             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1400                 1405                 1410             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1415                 1420                 1425             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    1430                 1435             


<210>  18
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN nucleotide sequence

<400>  18
ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca       60

tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc      120

gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc      180

ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct      240

cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct      300

gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt      360

gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg      420

cccaccagca ctgaagaagg tgcctcgagc                                       450


<210>  19
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-52-XTEN

<400>  19
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc     2100

atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac     2220

agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc     2280

ttctctcaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gccccccagt gctgaagagg     2760

caccagaggg agatcaccag gaccaccctg cagtctgacc aggaggagat cgactatgat     2820

gacaccatca gcgtggagat gaagaaggag gacttcgaca tctacgacga ggacgagaac     2880

cagagcccca ggagcttcca gaagaagacc aggcactact tcattgctgc tgtggagagg     2940

ctgtgggact atggcatgtc cagcagcccc catgtgctga ggaacagggc ccagtctggc     3000

agcgtgcccc agttcaagaa agtcgtgttc caggagttca ccgacggcag cttcacccag     3060

cccctgtaca gaggggagct gaacgagcac ctgggcctgc tgggccccta catcagggcc     3120

gaggtggagg acaacatcat ggtgaccttc aggaaccagg ccagcaggcc ctacagcttc     3180

tacagcagcc tgatcagcta cgaggaggac cagaggcagg gggctgagcc caggaagaac     3240

tttgtgaagc ccaatgaaac caagacctac ttctggaagg tgcagcacca catggccccc     3300

accaaggacg agttcgactg caaggcctgg gcctacttct ctgacgtgga cctggagaag     3360

gacgtgcact ctggcctgat tggccccctg ctggtgtgcc acaccaacac cctgaaccct     3420

gcccatggca ggcaggtgac tgtgcaggag ttcgccctgt tcttcaccat cttcgatgaa     3480

accaagagct ggtacttcac tgagaacatg gagaggaact gcagggcccc ctgcaacatc     3540

cagatggagg accccacctt caaggagaac tacaggttcc atgccatcaa tggctacatc     3600

atggacaccc tgcctggcct ggtcatggcc caggaccaga ggatcaggtg gtatctgctg     3660

agcatgggca gcaacgagaa catccacagc atccacttct ctggccacgt gttcactgtg     3720

aggaagaagg aggagtacaa gatggccctg tacaacctgt accctggggt gttcgaaacc     3780

gtggagatgc tgcccagcaa ggccggcatc tggagggtgg agtgcctgat tggggagcac     3840

ctgcacgccg gcatgagcac cctgttcctg gtgtacagca acaagtgcca gacccccctg     3900

ggcatggcct ctggccacat cagggacttc cagatcactg cctctggcca gtacggccag     3960

tgggccccca agctggccag gctgcactac tccggaagca tcaatgcctg gagcaccaag     4020

gagcccttca gctggatcaa agtggacctg ctggccccca tgatcatcca cggcatcaag     4080

acccaggggg ccaggcagaa gttctccagc ctgtacatca gccagttcat catcatgtac     4140

agcctggacg gcaagaagtg gcagacctac aggggcaaca gcaccggcac cctgatggtg     4200

ttcttcggca acgtggacag cagcggcatc aagcacaaca tcttcaaccc ccccatcatc     4260

gccagataca tcaggctgca ccccacccac tacagcatca ggagcaccct gaggatggag     4320

ctgatgggct gtgacctgaa cagctgcagc atgcccctgg gcatggagag caaggccatc     4380

tctgacgccc agatcactgc ctccagctac ttcaccaaca tgtttgccac ctggagcccc     4440

agcaaggcca ggctgcacct gcagggcagg agcaatgcct ggaggcccca ggtcaacaac     4500

cccaaggagt ggctgcaggt ggacttccag aagaccatga aggtgactgg ggtgaccacc     4560

cagggggtga agagcctgct gaccagcatg tacgtgaagg agttcctgat ctccagcagc     4620

caggacggcc accagtggac cctgttcttc cagaatggca aggtgaaggt gttccagggc     4680

aaccaggaca gcttcacccc tgtggtcaac agcctggacc cccccctgct gaccagatac     4740

ctgaggatcc acccccagag ctgggtgcac cagatcgccc tgaggatgga ggtgctgggc     4800

tgtgaggccc aggacctgta ctga                                            4824


<210>  20
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-1-XTEN

<400>  20
atgcagattg agctgtctac ttgctttttc ctgtgcctgc tgaggttttg cttttccgct       60

acacgaaggt attatctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc aaggtttccc cctagagtcc ctaagtcatt ccccttcaac      180

actagcgtgg tctacaagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gcaaagccta ggccaccctg gatgggactg ctggggccaa caatccaggc cgaggtgtac      300

gacaccgtgg tcattacact taagaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaagga gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc ggatctcata cctacgtgtg gcaggtcctg      480

aaagagaatg gccctatggc ctccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcggc ctgatcggag ccctgctggt gtgcagggaa      600

ggaagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag ggaaatcatg gcacagcgag acaaagaata gtctgatgca ggacagggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctgggc tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cgggatgggc      840

accacacctg aagtgcactc cattttcctg gagggacata cctttctggt ccgcaaccac      900

cgacaggctt ccctggagat ctctccaatt accttcctga cagcacagac tctgctgatg      960

gacctggggc agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcttacgtga aagtggactc ttgtcccgag gaacctcagc tgcggatgaa gaacaatgag     1080

gaagcagaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gctcctacaa atctcagtat ctgaacaatg ggccacagag gattggcaga     1320

aagtacaaga aagtgcggtt catggcatat accgatgaga ccttcaagac tcgcgaagcc     1380

atccagcacg agagcggcat cctgggacca ctgctgtacg gagaagtggg agacaccctg     1440

ctgatcattt tcaagaacca ggccagccgg ccttacaata tctatccaca tgggattaca     1500

gatgtgcgcc ctctgtacag caggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggagaaat cttcaagtac aagtggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctcggtg cctgacccgc tactattcta gtttcgtgaa tatggaaaga     1680

gatctggcaa gcggactgat cggaccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagcgg aatgtgattc tgttcagtgt ctttgacgaa     1800

aacaggtcat ggtacctgac cgagaacatc cagagattcc tgcctaatcc agctggggtg     1860

cagctggaag atcctgagtt tcaggcatct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtt tgcagctgag cgtgtgcctg cacgaggtcg cttactggta tatcctgagc     1980

attggggcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtctatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgagc     2100

atggagaatc ccggactgtg gattctgggg tgccacaaca gcgatttcag aaatcgcgga     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggggacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga accccggtct     2280

tttagtcaga atggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gccctccagt gctgaagcgg     2760

caccagcgcg agatcacccg cactaccctg cagagtgatc aggaagagat cgactacgac     2820

gatacaattt ctgtggaaat gaagaaagag gacttcgata tctatgacga agatgagaac     2880

cagagtcctc gatcattcca gaagaaaacc aggcattact ttattgccgc agtggagcgg     2940

ctgtgggatt atggcatgtc ctctagtcct cacgtgctgc gaaatagggc ccagtcagga     3000

agcgtcccac agttcaagaa agtggtcttc caggagttta cagacgggtc ctttactcag     3060

ccactgtaca ggggcgaact gaacgagcac ctgggactgc tggggcccta tatcagagca     3120

gaagtggagg ataacattat ggtcaccttc agaaatcagg cctctcggcc ttacagtttt     3180

tattcaagcc tgatctctta cgaagaggac cagcgacagg gagctgaacc acgaaaaaac     3240

ttcgtgaagc ctaatgagac caaaacatac ttttggaagg tgcagcacca tatggcccca     3300

acaaaagacg agttcgattg caaggcatgg gcctattttt ctgacgtgga tctggagaag     3360

gacgtgcaca gtggcctgat tggcccactg ctggtgtgcc atactaacac cctgaatcca     3420

gcccacggcc ggcaggtcac tgtccaggag ttcgctctgt tctttaccat ctttgatgag     3480

acaaagagct ggtacttcac cgaaaacatg gagcgaaatt gcagggctcc atgtaacatt     3540

cagatggaag accccacatt caaggagaac taccgctttc atgctatcaa tggatacatc     3600

atggatactc tgcccgggct ggtcatggca caggaccaga gaatccggtg gtatctgctg     3660

agcatgggca gcaacgagaa tatccactca attcatttca gcgggcacgt gtttactgtc     3720

aggaagaaag aagagtacaa gatggccctg tacaacctgt atcccggcgt gttcgaaacc     3780

gtcgagatgc tgcctagcaa ggccggaatc tggagagtgg aatgcctgat tggagagcac     3840

ctgcatgctg ggatgtctac cctgtttctg gtgtacagta ataagtgtca gacacccctg     3900

ggaatggcat ccgggcatat cagggatttc cagattaccg catctggaca gtacggacag     3960

tgggcaccta agctggctag actgcactat tccggatcta tcaacgcttg gtccacaaaa     4020

gagcctttct cttggattaa ggtggacctg ctggccccaa tgatcattca tggcatcaaa     4080

actcagggag ctcggcagaa gttctcctct ctgtacatct cacagtttat catcatgtac     4140

agcctggatg ggaagaaatg gcagacatac cgcggcaata gcacaggaac tctgatggtg     4200

ttctttggca acgtggacag cagcggaatc aagcacaaca ttttcaatcc ccctatcatt     4260

gctagataca tccggctgca cccaacccat tattctattc gaagtacact gaggatggaa     4320

ctgatgggat gcgatctgaa cagttgttca atgcccctgg ggatggagtc caaggcaatc     4380

tctgacgccc agattaccgc cagctcctac ttcactaata tgtttgctac ctggagccct     4440

tccaaagcaa gactgcacct gcaaggccgc agcaacgcat ggcgaccaca ggtgaacaat     4500

cccaaggagt ggttgcaggt cgattttcag aaaactatga aggtgaccgg ggtcacaact     4560

cagggcgtga aaagtctgct gacctcaatg tacgtcaagg agttcctgat ctctagttca     4620

caggacggac atcagtggac actgttcttt cagaacggga aggtgaaagt cttccagggc     4680

aatcaggatt cctttacacc tgtggtcaac agtctagacc ctccactgct gaccagatac     4740

ctgagaatcc accctcagtc ctgggtgcac cagattgccc tgagaatgga agtgctggga     4800

tgcgaggccc aggatctgta ctga                                            4824


<210>  21
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAR/ARS

<400>  21
atattt                                                                   6


<210>  22
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAR/ARS

<400>  22
aaatat                                                                   6


<210>  23
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  destabilizing element

<400>  23
attta                                                                    5


<210>  24
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  destabilizing element

<400>  24
taaat                                                                    5


<210>  25
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly-T site

<400>  25
tttttt                                                                   6


<210>  26
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly-A site

<400>  26
aaaaaaa                                                                  7


<210>  27
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice site

<400>  27
ggtgat                                                                   6


<210>  28
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TATA box

<400>  28
tataa                                                                    5


<210>  29
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TATA box

<400>  29
ttata                                                                    5


<210>  30
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AU rich sequence element

<400>  30
attttatt                                                                 8


<210>  31
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AU rich sequence element

<400>  31
atttttaa                                                                 8


<210>  32
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  kozak consensus sequence

<400>  32
gccgccacca tgc                                                          13


<210>  33
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP peptide

<400>  33

Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
            20                  25                  30          


<210>  34
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP peptide

<400>  34

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  albumin-binding peptide core sequence

<400>  35

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  36

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  37

Ala Ala Pro Ala Ser Pro Ala Pro Ala Ala Pro Ser Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ser 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  38

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser Ser 
            20  


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  39

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  40

Ser Ser Pro Ser Ala Pro Ser Pro Ser Ser Pro Ala Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ser Pro Ala 
            20  


<210>  41
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  41

Ala Ala Ser Pro Ala Ala Pro Ser Ala Pro Pro Ala Ala Ala Ser Pro 
1               5                   10                  15      


Ala Ala Pro Ser Ala Pro Pro Ala 
            20                  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  42

Ala Ser Ala Ala Ala Pro Ala Ala Ala Ser Ala Ala Ala Ser Ala Pro 
1               5                   10                  15      


Ser Ala Ala Ala 
            20  


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR142 target

<400>  43
tccataaagt aggaaacact aca                                               23


<210>  44
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 233-236 of human IgG1

<400>  45

Glu Leu Leu Gly 
1               


<210>  46
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE42-4, protein sequence

<400>  46

Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
1               5                   10                  15      


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
            20                  25                  30          


Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser 
        35                  40          


<210>  47
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE42-4, DNA sequence

<400>  47
ggcgcgccag gttctcctgc tggctccccc acctcaacag aagaggggac aagcgaaagc       60

gctacgcctg agagtggccc tggctctgag ccagccacct ccggctctga aacccctgcc      120

tcgagc                                                                 126


<210>  48
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-2A, protein sequence

<400>  48

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
    130                 135                 140                 


<210>  49
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-2A, DNA sequence

<400>  49
ggcgcgccaa ccagtacgga gccgtccgag gggagcgcac caggaagccc ggctgggagc       60

ccgacttcta ccgaagaggg tacatctacc gaaccaagtg aaggttcagc accaggcacc      120

tcaacagaac cctctgaggg ctcggcgcct ggtacaagtg agtccgccac cccagaatcc      180

gggcctggga caagcacaga accttcggaa gggagtgccc ctggaacatc cgaatcggca      240

accccagaat cagggccagg atctgagccc gcgacttcgg gctccgagac gcctgggaca      300

tccaccgagc cctccgaagg atcagcccca ggcaccagca cggagccctc tgagggaagc      360

gcacctggta ccagcgaaag cgcaactccc gaatcaggtc ccggtacgag cgagtcggcg      420

accccggaga gcgggccagg tgcctcgagc                                       450


<210>  50
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-3B, protein sequence

<400>  50

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
65                  70                  75                  80  


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 
            100                 105                 110         


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  51
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-3B, DNA sequence

<400>  51
ggcgcgccaa gtcccgctgg aagcccaact agcaccgaag aggggacctc agagtccgcc       60

acccccgagt ccggccctgg ctctgagcct gccactagcg gctccgagac tcctggcaca      120

tccgaaagcg ctacacccga gagtggaccc ggcacctcta ccgagcccag tgagggctcc      180

gcccctggaa caagcaccga gcccagcgaa ggcagcgccc cagggacctc cacagagccc      240

agtgaaggca gtgctcctgg caccagcacc gaaccaagcg agggctctgc acccgggacc      300

tccaccgagc caagcgaagg ctctgcccct ggcacttcca ccgagcccag cgaaggcagc      360

gcccctggga gccccgctgg ctctcccacc agcactgagg agggcacatc taccgaacca      420

agtgaaggct ctgcaccagg tgcctcgagc                                       450


<210>  52
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-4A, protein sequence

<400>  52

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
65                  70                  75                  80  


Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
                85                  90                  95      


Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 
            100                 105                 110         


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  53
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-4A, DNA sequence

<400>  53
ggcgcgccaa cgtccgaaag tgctacccct gagtcaggcc ctggtagtga gcctgccaca       60

agcggaagcg aaactccggg gacctcagag tctgccactc ccgaatcggg gccaggctct      120

gaaccggcca cttcagggag cgaaacacca ggaacatcgg agagcgctac cccggagagc      180

gggccaggaa ctagtactga gcctagcgag ggaagtgcac ctggtacaag cgagtccgcc      240

acacccgagt ctggccctgg ctctccagcg ggctcaccca cgagcactga agagggctct      300

cccgctggca gcccaacgtc gacagaagaa ggatcaccag caggctcccc cacatcaaca      360

gaggagggta catcagaatc tgctactccc gagagtggac ccggtacctc cactgagccc      420

agcgagggga gtgcaccagg tgcctcgagc                                       450


<210>  54
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-5A, protein sequence

<400>  54

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
    50                  55                  60                  


Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
                85                  90                  95      


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            100                 105                 110         


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
        115                 120                 125             


Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
    130                 135                 140                 


<210>  55
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-5A, DNA sequence

<400>  55
ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca       60

tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc      120

gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc      180

ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct      240

cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct      300

gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt      360

gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg      420

cccaccagca ctgaagaagg tgcctcgagc                                       450


<210>  56
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-6B, protein sequence

<400>  56

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
        35                  40                  45              


Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
    50                  55                  60                  


Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
65                  70                  75                  80  


Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
                85                  90                  95      


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 
            100                 105                 110         


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        115                 120                 125             


Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    130                 135                 140                 


<210>  57
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AE144-6B, DNA sequence

<400>  57
ggcgcgccaa catctaccga gccttccgaa ggctctgccc ctgggacctc agaatctgca       60

acccctgaaa gcggccctgg aacctccgaa agtgccactc ccgagagcgg cccagggaca      120

agcgagtcag caacccctga gtctggaccc ggcagcgagc ctgcaacctc tggctcagag      180

actcccggct cagaacccgc tacctcaggc tccgagacac ccggctctcc tgctgggagt      240

cccacttcca ccgaggaagg aacatccact gagcctagtg agggctctgc ccctggaacc      300

agcacagagc caagtgaggg cagtgcacca ggatccgagc cagcaaccag cgggtccgag      360

actcccggga cctctgagtc tgccacccca gagagcggac ccggcacttc aaccgagccc      420

tccgaaggat cagcaccagg tgcctcgagc                                       450


<210>  58
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-1, protein sequence

<400>  58

Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser 
1               5                   10                  15      


Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 
            20                  25                  30          


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
        35                  40                  45              


Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser 
    50                  55                  60                  


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 
65                  70                  75                  80  


Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 
                85                  90                  95      


Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser 
            100                 105                 110         


Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 
        115                 120                 125             


Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 
    130                 135                 140                 


<210>  59
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-1, DNA sequence

<400>  59
ggcgcgccac ccgggtcgtc cccgtcggcg tccaccggaa cagggccagg gtcatccccg       60

tcagcgtcga ctgggacggg acccgggaca cccggttcgg ggactgcatc ctcctcgcct      120

ggttcgtcca ccccgtcagg agccacgggt tcgccgggaa gcagcccaag cgcatccact      180

ggtacagggc ctggggcttc accgggtact tcatccacgg ggtcaccggg aacgcccgga      240

tcggggacgg cttcctcatc accaggatcg tcaacaccct cgggcgcaac gggcagcccc      300

ggaacccctg gttcgggtac ggcgtcgtcg agccccggtg cgagcccggg aacaagctcg      360

acaggatcgc ctggggcgtc acccggcacg tcgagcacag gcagccccgg aacccctgga      420

tcgggaaccg cgtcgtcaag cgcctcgagc                                       450


<210>  60
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-A, protein sequence

<400>  60

Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
            20                  25                  30          


Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 
            100                 105                 110         


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  61
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-A, DNA sequence

<400>  61
ggcgcgccag gtgcctcgcc gggaacatca tcaactggtt cacccgggtc atccccctcg       60

gcctcaaccg ggacgggtcc cggctcatcc cccagcgcca gcactggaac aggtcctggc      120

actcctggtt ccggtacggc atcgtcatcc ccgggaagct caacaccgtc cggagcgaca      180

ggatcacctg gctcgtcacc ttcggcgtca actggaacgg ggccaggggc ctcacccgga      240

acgtcctcga ctgggtcgcc tggtacgccg ggatcaggaa cggcctcatc ctcgcctggg      300

tcctcaacgc cctcgggtgc gactggttcg ccgggaactc ctggctcggg gacggcctcg      360

tcgtcgcctg gggcatcacc ggggacgagc tccacggggt cccctggagc gtcaccgggg      420

acctcctcga caggtagccc ggcctcgagc                                       450


<210>  62
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-B, protein sequence

<400>  62

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
1               5                   10                  15      


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 
65                  70                  75                  80  


Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
                85                  90                  95      


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 
            100                 105                 110         


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  63
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-B, DNA sequence

<400>  63
ggcgcgccag gtacaccggg cagcggcacg gcttcgtcgt cacccggctc gtccacaccg       60

tcgggagcta cgggaagccc aggagcgtca ccgggaacgt cgtcaacggg gtcaccgggt      120

acgccaggta gcggcacggc cagcagctcg ccaggttcat cgaccccgtc gggagcgact      180

gggtcgcccg gatcaagccc gtcagcttcc actggaacag gacccgggtc gtcgccgtca      240

gcctcaacgg ggacaggacc tggttcatcg acgccgtcag gggcgacagg ctcgcccgga      300

tcgtcaacac cctcgggggc aacggggagc cctggtgcgt cgcctggaac ctcatccacc      360

ggaagcccgg gggcctcgcc gggtacgagc tccacgggat cgcccggagc gtcccccgga      420

acttcaagca cagggagccc tgcctcgagc                                       450


<210>  64
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-C, protein sequence

<400>  64

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 
1               5                   10                  15      


Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        35                  40                  45              


Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 
    50                  55                  60                  


Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
                85                  90                  95      


Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 
            100                 105                 110         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  65
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-C, DNA sequence

<400>  65
ggcgcgccag gtacacccgg atcgggtaca gcgtcatcga gccccggtgc gtcacctggt       60

acgtcgagca cggggtcgcc aggggcgtcc cctgggacgt cctcaacagg ctcgcccggt      120

gcgtcacccg gcacgtcgtc cacgggttca cctggtagct ccccttccgc gtccactggc      180

accgggcctg gaactccggg gagcggcaca gcgagctcgt cgccgggagc atcgcctggg      240

acatcgagca ccgggtcgcc aggagcatcg cccggaacat ccagcacagg aagccccggc      300

gcgtcgcccg ggacatcaag cacaggttcc ccgggatcga gcacgccgtc cggagccact      360

ggatcaccag ggagctcgac accttccggc gcaacgggat cgcccggagc cagcccgggt      420

acgtcaagca ctggctcccc tgcctcgagc                                       450


<210>  66
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-F, protein sequence

<400>  66

Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 
1               5                   10                  15      


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
            20                  25                  30          


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
        35                  40                  45              


Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 
    50                  55                  60                  


Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 
65                  70                  75                  80  


Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
                85                  90                  95      


Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 
            100                 105                 110         


Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 
        115                 120                 125             


Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
    130                 135                 140                 


<210>  67
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XTEN AG144-F, DNA sequence

<400>  67
ggcgcgccag gctccagccc ctccgcgagc acgggaaccg gaccaggttc gtcaccctca       60

gcatcaacgg ggacgggacc gggggcgtca ccaggaacgt cctccaccgg ctcgccgggt      120

gcatcacccg gaacgtcatc gaccggatcg ccagggagct cgacgccatc aggcgcaaca      180

ggatcacctg gctcaagccc tagcgcgtca accggcacgg gtccgggtgc ctcccctggc      240

acgtccagca ccggatcacc cggatcgagc ccatccgcct caaccggaac cggacccggt      300

acaccagggt cgggaacagc ctcctcgtca ccaggctcct caaccccctc gggagccacg      360

ggttcgcccg gttcgtcaac gccttccgga gcaactggta gccccggagc atcgccagga      420

acttcgagca cggggtcgcc cgcctcgagc                                       450


<210>  68
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-1  DNA Sequence

<400>  68
atgcagattg agctgtctac ttgctttttc ctgtgcctgc tgaggttttg cttttccgct       60

acacgaaggt attatctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc aaggtttccc cctagagtcc ctaagtcatt ccccttcaac      180

actagcgtgg tctacaagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gcaaagccta ggccaccctg gatgggactg ctggggccaa caatccaggc cgaggtgtac      300

gacaccgtgg tcattacact taagaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaagga gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc ggatctcata cctacgtgtg gcaggtcctg      480

aaagagaatg gccctatggc ctccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcggc ctgatcggag ccctgctggt gtgcagggaa      600

ggaagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag ggaaatcatg gcacagcgag acaaagaata gtctgatgca ggacagggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctgggc tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cgggatgggc      840

accacacctg aagtgcactc cattttcctg gagggacata cctttctggt ccgcaaccac      900

cgacaggctt ccctggagat ctctccaatt accttcctga cagcacagac tctgctgatg      960

gacctggggc agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcttacgtga aagtggactc ttgtcccgag gaacctcagc tgcggatgaa gaacaatgag     1080

gaagcagaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gctcctacaa atctcagtat ctgaacaatg ggccacagag gattggcaga     1320

aagtacaaga aagtgcggtt catggcatat accgatgaga ccttcaagac tcgcgaagcc     1380

atccagcacg agagcggcat cctgggacca ctgctgtacg gagaagtggg agacaccctg     1440

ctgatcattt tcaagaacca ggccagccgg ccttacaata tctatccaca tgggattaca     1500

gatgtgcgcc ctctgtacag caggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggagaaat cttcaagtac aagtggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctcggtg cctgacccgc tactattcta gtttcgtgaa tatggaaaga     1680

gatctggcaa gcggactgat cggaccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagcgg aatgtgattc tgttcagtgt ctttgacgaa     1800

aacaggtcat ggtacctgac cgagaacatc cagagattcc tgcctaatcc agctggggtg     1860

cagctggaag atcctgagtt tcaggcatct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtt tgcagctgag cgtgtgcctg cacgaggtcg cttactggta tatcctgagc     1980

attggggcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtctatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgagc     2100

atggagaatc ccggactgtg gattctgggg tgccacaaca gcgatttcag aaatcgcgga     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggggacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga accccggtct     2280

tttagtcaga atcctccagt gctgaagagg caccagaggg agatcacccg cactaccctg     2340

cagagtgatc aggaagagat cgactacgac gatacaattt ctgtggaaat gaagaaagag     2400

gacttcgata tctatgacga agatgagaac cagagtcctc gatcattcca gaagaaaacc     2460

aggcattact ttattgccgc agtggagcgg ctgtgggatt atggcatgtc ctctagtcct     2520

cacgtgctgc gaaatagggc ccagtcagga agcgtcccac agttcaagaa agtggtcttc     2580

caggagttta cagacgggtc ctttactcag ccactgtaca ggggcgaact gaacgagcac     2640

ctgggactgc tggggcccta tatcagagca gaagtggagg ataacattat ggtcaccttc     2700

agaaatcagg cctctcggcc ttacagtttt tattcaagcc tgatctctta cgaagaggac     2760

cagcgacagg gagctgaacc acgaaaaaac ttcgtgaagc ctaatgagac caaaacatac     2820

ttttggaagg tgcagcacca tatggcccca acaaaagacg agttcgattg caaggcatgg     2880

gcctattttt ctgacgtgga tctggagaag gacgtgcaca gtggcctgat tggcccactg     2940

ctggtgtgcc atactaacac cctgaatcca gcccacggcc ggcaggtcac tgtccaggag     3000

ttcgctctgt tctttaccat ctttgatgag acaaagagct ggtacttcac cgaaaacatg     3060

gagcgaaatt gcagggctcc atgtaacatt cagatggaag accccacatt caaggagaac     3120

taccgctttc atgctatcaa tggatacatc atggatactc tgcccgggct ggtcatggca     3180

caggaccaga gaatccggtg gtatctgctg agcatgggca gcaacgagaa tatccactca     3240

attcatttca gcgggcacgt gtttactgtc aggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt atcccggcgt gttcgaaacc gtcgagatgc tgcctagcaa ggccggaatc     3360

tggagagtgg aatgcctgat tggagagcac ctgcatgctg ggatgtctac cctgtttctg     3420

gtgtacagta ataagtgtca gacacccctg ggaatggcat ccgggcatat cagggatttc     3480

cagattaccg catctggaca gtacggacag tgggcaccta agctggctag actgcactat     3540

tccggatcta tcaacgcttg gtccacaaaa gagcctttct cttggattaa ggtggacctg     3600

ctggccccaa tgatcattca tggcatcaaa actcagggag ctcggcagaa gttctcctct     3660

ctgtacatct cacagtttat catcatgtac agcctggatg ggaagaaatg gcagacatac     3720

cgcggcaata gcacaggaac tctgatggtg ttctttggca acgtggacag cagcggaatc     3780

aagcacaaca ttttcaatcc ccctatcatt gctagataca tccggctgca cccaacccat     3840

tattctattc gaagtacact gaggatggaa ctgatgggat gcgatctgaa cagttgttca     3900

atgcccctgg ggatggagtc caaggcaatc tctgacgccc agattaccgc cagctcctac     3960

ttcactaata tgtttgctac ctggagccct tccaaagcaa gactgcacct gcaaggccgc     4020

agcaacgcat ggcgaccaca ggtgaacaat cccaaggagt ggttgcaggt cgattttcag     4080

aaaactatga aggtgaccgg ggtcacaact cagggcgtga aaagtctgct gacctcaatg     4140

tacgtcaagg agttcctgat ctctagttca caggacggac atcagtggac actgttcttt     4200

cagaacggga aggtgaaagt cttccagggc aatcaggatt cctttacacc tgtggtcaac     4260

agtctagacc ctccactgct gaccagatac ctgagaatcc accctcagtc ctgggtgcac     4320

cagattgccc tgagaatgga agtgctggga tgcgaggccc aggatctgta ctga           4374


<210>  69
<211>  577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ET Promoter, DNA sequence

<400>  69
ctcgaggtca attcacgcga gttaataatt accagcgcgg gccaaataaa taatccgcga       60

ggggcaggtg acgtttgccc agcgcgcgct ggtaattatt aacctcgcga atattgattc      120

gaggccgcga ttgccgcaat cgcgaggggc aggtgacctt tgcccagcgc gcgttcgccc      180

cgccccggac ggtatcgata agcttaggag cttgggctgc aggtcgaggg cactgggagg      240

atgttgagta agatggaaaa ctactgatga cccttgcaga gacagagtat taggacatgt      300

ttgaacaggg gccgggcgat cagcaggtag ctctagagga tccccgtctg tctgcacatt      360

tcgtagagcg agtgttccga tactctaatc tccctaggca aggttcatat ttgtgtaggt      420

tacttattct ccttttgttg actaagtcaa taatcagaat cagcaggttt ggagtcagct      480

tggcagggat cagcagcctg ggttggaagg agggggtata aaagcccctt caccaggaga      540

agccgtcaca cagatccaca agctcctgcc accatgg                               577


<210>  70
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-5

<400>  70
atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg       60

acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt      120

ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac      180

acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac      300

gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg      360

ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga      420

gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg      480

aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac      540

gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa      600

ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg      660

ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat      720

gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc      780

ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg      840

accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac      900

cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg      960

gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag     1020

gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag     1080

gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat     1140

gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc     1200

tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct     1260

cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga     1320

aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc     1380

atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt     1440

ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact     1500

gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt     1560

ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca     1620

actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc     1680

gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa     1740

cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa     1800

aaccggtcgt ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg     1860

cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg     1920

ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc     1980

attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag     2040

atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc     2100

atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga     2160

atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac     2220

tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc     2280

ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg     2340

cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag     2400

gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc     2460

cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg     2520

cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc     2580

caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat     2640

ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc     2700

cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac     2760

cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg     2880

gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg     2940

ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag     3000

ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg     3060

gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac     3120

taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc     3180

caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct     3240

attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg     3300

tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt     3360

tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg     3420

gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc     3480

cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac     3540

tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt     3600

ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca     3660

ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac     3720

agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt     3780

aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac     3840

tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc     3900

atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac     3960

tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga     4020

tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag     4080

aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg     4140

tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc     4200

caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac     4260

tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac     4320

cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga           4374


<210>  71
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-6

<400>  71
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc     2340

caatcggatc aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa     2400

gatttcgata tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact     2460

agacactact ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct     2520

cacgtccttc ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc     2580

caggagttca ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac     2640

ctgggcctgc tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc     2700

cgtaaccaag catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac     2760

cagcgccaag gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac     2820

ttctggaagg tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg     2880

gcctacttct ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg     2940

ctcgtgtgtc acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag     3000

tttgctctgt tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg     3060

gagcgaaact gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac     3120

tatagattcc acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc     3180

caggatcaga ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc     3240

attcacttct ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg     3300

tacaatctgt accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc     3360

tggagagtgg agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg     3420

gtgtactcga ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc     3480

cagatcacag caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac     3540

tccggatcga tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc     3600

ctggccccta tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc     3660

ctgtacatct cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac     3720

aggggaaact ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt     3780

aagcacaaca tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac     3840

tactcaatcc gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc     3900

atgccgttgg ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac     3960

ttcactaaca tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg     4020

tcaaatgcct ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa     4080

aagaccatga aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg     4140

tatgtgaagg agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc     4200

caaaacggaa aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac     4260

tccctggacc ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat     4320

cagattgcat tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctga           4374


<210>  72
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coFVIII-6-XTEN

<400>  72
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gcccgcctgt gctgaagagg     2760

caccagcgag aaattacccg gaccaccctc caatcggatc aggaggaaat cgactacgac     2820

gacaccatct cggtggaaat gaagaaggaa gatttcgata tctacgacga ggacgaaaat     2880

cagtcccctc gctcattcca aaagaaaact agacactact ttatcgccgc ggtggaaaga     2940

ctgtgggact atggaatgtc atccagccct cacgtccttc ggaaccgggc ccagagcgga     3000

tcggtgcctc agttcaagaa agtggtgttc caggagttca ccgacggcag cttcacccag     3060

ccgctgtacc ggggagaact gaacgaacac ctgggcctgc tcggtcccta catccgcgcg     3120

gaagtggagg ataacatcat ggtgaccttc cgtaaccaag catccagacc ttactccttc     3180

tattcctccc tgatctcata cgaggaggac cagcgccaag gcgccgagcc ccgcaagaac     3240

ttcgtcaagc ccaacgagac taagacctac ttctggaagg tccaacacca tatggccccg     3300

accaaggatg agtttgactg caaggcctgg gcctacttct ccgacgtgga ccttgagaag     3360

gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc acaccaacac cctgaaccca     3420

gcgcatggac gccaggtcac cgtccaggag tttgctctgt tcttcaccat ttttgacgaa     3480

actaagtcct ggtacttcac cgagaatatg gagcgaaact gtagagcgcc ctgcaatatc     3540

cagatggaag atccgacttt caaggagaac tatagattcc acgccatcaa cgggtacatc     3600

atggatactc tgccggggct ggtcatggcc caggatcaga ggattcggtg gtacttgctg     3660

tcaatgggat cgaacgaaaa cattcactcc attcacttct ccggtcacgt gttcactgtg     3720

cgcaagaagg aggagtacaa gatggcgctg tacaatctgt accccggggt gttcgaaact     3780

gtggagatgc tgccgtccaa ggccggcatc tggagagtgg agtgcctgat cggagagcac     3840

ctccacgcgg ggatgtccac cctcttcctg gtgtactcga ataagtgcca gaccccgctg     3900

ggcatggcct cgggccacat cagagacttc cagatcacag caagcggaca atacggccaa     3960

tgggcgccga agctggcccg cttgcactac tccggatcga tcaacgcatg gtccaccaag     4020

gaaccgttct cgtggattaa ggtggacctc ctggccccta tgattatcca cggaattaag     4080

acccagggcg ccaggcagaa gttctcctcc ctgtacatct cgcaattcat catcatgtac     4140

agcctggacg ggaagaagtg gcagacttac aggggaaact ccaccggcac cctgatggtc     4200

tttttcggca acgtggattc ctccggcatt aagcacaaca tcttcaaccc accgatcata     4260

gccagatata ttaggctcca ccccactcac tactcaatcc gctcaactct tcggatggaa     4320

ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg ggatggaatc aaaggctatt     4380

agcgacgccc agatcaccgc gagctcctac ttcactaaca tgttcgccac ctggagcccc     4440

tccaaggcca ggctgcactt gcagggacgg tcaaatgcct ggcggccgca agtgaacaat     4500

ccgaaggaat ggcttcaagt ggatttccaa aagaccatga aagtgaccgg agtcaccacc     4560

cagggagtga agtcccttct gacctcgatg tatgtgaagg agttcctgat tagcagcagc     4620

caggacgggc accagtggac cctgttcttc caaaacggaa aggtcaaggt gttccagggg     4680

aaccaggact cgttcacacc cgtggtgaac tccctggacc ccccactgct gacgcggtac     4740

ttgaggattc atcctcagtc ctgggtccat cagattgcat tgcgaatgga agtcctgggc     4800

tgcgaggccc aggacctgta ctga                                            4824


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  73

Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 
1               5                   10          


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  74

Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  75

Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD motif

<400>  76

Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 
1               5                   10          


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM motif

<400>  77

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
1               5                   10          


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM, AQ motif

<400>  78

Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
1               5                   10          


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM, AQ motif

<400>  79

Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AE, AM, AQ motif

<400>  80

Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  81

Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 
1               5                   10          


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  82

Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  83

Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 
1               5                   10          


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF, AM motif

<400>  84

Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  85

Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  86

Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 
1               5                   10          


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  87

Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 
1               5                   10          


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG, AM motif

<400>  88

Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 
1               5                   10          


<210>  89
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  89

Gly Glu Pro Ala Gly Ser Pro Thr Ser Thr Ser Glu 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  90

Gly Thr Gly Glu Pro Ser Ser Thr Pro Ala Ser Glu 
1               5                   10          


<210>  91
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  91

Gly Ser Gly Pro Ser Thr Glu Ser Ala Pro Thr Glu 
1               5                   10          


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  92

Gly Ser Glu Thr Pro Ser Gly Pro Ser Glu Thr Ala 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  93

Gly Pro Ser Glu Thr Ser Thr Ser Glu Pro Gly Ala 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQ motif

<400>  94

Gly Ser Pro Ser Glu Pro Thr Glu Gly Thr Ser Ala 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  95

Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 
1               5                   10          


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  96

Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 
1               5                   10          


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  97

Gly Thr Ser Glu Pro Ser Thr Ser Glu Pro Gly Ala 
1               5                   10          


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC motif

<400>  98

Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 
1               5                   10          


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  99

Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 
1               5                   10          


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  100

Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  101

Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 
1               5                   10          


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD motif

<400>  102

Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 
1               5                   10          


<210>  103
<211>  1607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coFVIII-6-XTEN Protein Sequence

<400>  103

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Ala Pro Thr 
        755                 760                 765             


Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 
    770                 775                 780                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
785                 790                 795                 800 


Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 
                805                 810                 815     


Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 
            820                 825                 830         


Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
        835                 840                 845             


Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 
    850                 855                 860                 


Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
865                 870                 875                 880 


Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
                885                 890                 895     


Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ala 
            900                 905                 910         


Ser Ser Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 
        915                 920                 925             


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
    930                 935                 940                 


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
945                 950                 955                 960 


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
                965                 970                 975     


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
            980                 985                 990         


Leu Arg Asn Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 
        995                 1000                 1005             


Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 
    1010                 1015                 1020             


Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 
    1025                 1030                 1035             


Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 
    1040                 1045                 1050             


Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 
    1055                 1060                 1065             


Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 
    1070                 1075                 1080             


Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 
    1085                 1090                 1095             


Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 
    1100                 1105                 1110             


Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 
    1115                 1120                 1125             


Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 
    1130                 1135                 1140             


Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
    1145                 1150                 1155             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1160                 1165                 1170             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1175                 1180                 1185             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1190                 1195                 1200             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1205                 1210                 1215             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1220                 1225                 1230             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1235                 1240                 1245             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    1250                 1255                 1260             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    1265                 1270                 1275             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    1280                 1285                 1290             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    1295                 1300                 1305             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    1310                 1315                 1320             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    1325                 1330                 1335             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    1340                 1345                 1350             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    1355                 1360                 1365             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    1370                 1375                 1380             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    1385                 1390                 1395             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    1400                 1405                 1410             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    1415                 1420                 1425             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    1430                 1435                 1440             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    1445                 1450                 1455             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    1460                 1465                 1470             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    1475                 1480                 1485             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    1490                 1495                 1500             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 
    1505                 1510                 1515             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    1520                 1525                 1530             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    1535                 1540                 1545             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    1550                 1555                 1560             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    1565                 1570                 1575             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    1580                 1585                 1590             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1595                 1600                 1605         


