                         SEQUENCE LISTING

<110>  LFB
 
<120>  DIMERE DE VARIANTS DU FACTEUR X

<130>  BFF170501

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
1               5                   10                  15      


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
            20                  25                  30          


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
        35                  40                  45              


Asn Leu Thr Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys 
    50                  55                  60                  


Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly 
65                  70                  75                  80  


Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu 
                85                  90                  95      


Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu 
            100                 105                 110         


Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys 
        115                 120                 125             


His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu 
    130                 135                 140                 


Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys 
145                 150                 155                 160 


Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr 
                165                 170                 175     


Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser 
            180                 185                 190         


Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys 
        195                 200                 205             


Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly 
    210                 215                 220                 


Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
225                 230                 235                 240 


His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser 
                245                 250                 255     


Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
            260                 265                 270         


Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly 
        275                 280                 285             


Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro 
    290                 295                 300                 


Leu Lys 
305     


<210>  2
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg 
            180         


<210>  3
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
1               5                   10                  15      


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
            20                  25                  30          


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
        35                  40                  45              


Asn Leu Thr Arg 
    50          


<210>  4
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  5
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg 
    130                 135                 140         


<210>  6
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  7
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala 
            20                  25                  30      


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Asn Asn Ile Leu Ala Arg Val Thr Arg 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Asn Asn Ile Leu Ala Arg Val Arg Arg 
1               5                   


<210>  10
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Arg Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Asp Phe Leu Ala Glu Gly Gly Gly Val Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  11
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant de SEQ ID NO :1 comprenant l'insertion de DFLAEGLTPR entre
       les acides amins 52 et 53 (mutation selon l'invention)

<400>  11

Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
1               5                   10                  15      


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
            20                  25                  30          


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
        35                  40                  45              


Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu Thr Pro Arg Ile Val 
    50                  55                  60                  


Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu 
65                  70                  75                  80  


Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu 
                85                  90                  95      


Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe 
            100                 105                 110         


Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu 
        115                 120                 125             


Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys 
    130                 135                 140                 


Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile 
145                 150                 155                 160 


Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp 
                165                 170                 175     


Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe 
            180                 185                 190         


Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu 
        195                 200                 205             


Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe 
    210                 215                 220                 


Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu 
225                 230                 235                 240 


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys 
                245                 250                 255     


Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala 
            260                 265                 270         


Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys 
        275                 280                 285             


Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser 
    290                 295                 300                 


His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
305                 310                 315     


<210>  12
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamre

<400>  12
ccacgacctc gcacatgact tgaagtaaaa cgcgaattac                             40


<210>  13
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln His Val Phe Leu Ala Pro Gln Gln Ala Arg Ser Leu Leu Gln Arg 
1               5                   10                  15      


Val Arg Arg 
            


<210>  14
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  propeptide FVIIv1

<400>  14

Ala Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp Met Pro 
1               5                   10                  15      


Trp Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu Ala His 
            20                  25                  30          


Gly Val Leu His Arg Arg Arg Arg 
        35                  40  


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  propeptide FVIIv2

<400>  15

Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val Leu His Arg Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  16
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg Ala His 
1               5                   10                  15      


Gln Val Leu Arg Ile Arg Lys Arg 
            20                  


<210>  17
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FX-IIa

<400>  17

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Ser Val 
    130                 135                 140                 


Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile Thr Trp 
145                 150                 155                 160 


Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro Phe Asp 
                165                 170                 175     


Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn Asn Leu 
            180                 185                 190         


Thr Arg Asp Phe Leu Ala Glu Gly Leu Thr Pro Arg Ile Val Gly Gly 
        195                 200                 205             


Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn 
    210                 215                 220                 


Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr 
225                 230                 235                 240 


Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val 
                245                 250                 255     


Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val 
            260                 265                 270         


His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr 
        275                 280                 285             


Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe 
    290                 295                 300                 


Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu 
305                 310                 315                 320 


Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg 
                325                 330                 335     


Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val 
            340                 345                 350         


Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile 
        355                 360                 365             


Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala 
    370                 375                 380                 


Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr 
385                 390                 395                 400 


Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys 
                405                 410                 415     


Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile 
            420                 425                 430         


Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala 
        435                 440                 445             


Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
    450                 455             


<210>  18
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide signal du facteur X humain fusionn au propeptide de la 
       thrombine

<400>  18

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Gln 
            20                  25                  30          


His Val Phe Leu Ala Pro Gln Gln Ala Arg Ser Leu Leu Gln Arg Val 
        35                  40                  45              


Arg Arg 
    50  


<210>  19
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide signal du facteur X humain fusionn  FVIIv1

<400>  19

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp Met Pro Trp 
        35                  40                  45              


Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu Ala His Gly 
    50                  55                  60                  


Val Leu His Arg Arg Arg Arg 
65                  70      


<210>  20
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide signal du facteur X humain fusionn  FVIIv2

<400>  20

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Val Phe Val Thr Gln Glu Glu Ala His Gly Val Leu His Arg Arg Arg 
        35                  40                  45              


Arg 
    


<210>  21
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide signal du facteur X humain fusionn au propeptide de la 
       protine C

<400>  21

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Thr 
            20                  25                  30          


Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg Ala His Gln 
        35                  40                  45              


Val Leu Arg Ile Arg Lys Arg 
    50                  55  


<210>  22
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protine selon l'invention

<400>  22

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Gln 
            20                  25                  30          


His Val Phe Leu Ala Pro Gln Gln Ala Arg Ser Leu Leu Gln Arg Val 
        35                  40                  45              


Arg Arg Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu 
    50                  55                  60                  


Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val 
65                  70                  75                  80  


Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp 
                85                  90                  95      


Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys 
            100                 105                 110         


Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly 
        115                 120                 125             


Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly 
    130                 135                 140                 


Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser 
145                 150                 155                 160 


Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro 
                165                 170                 175     


Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg 
            180                 185                 190         


Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
        195                 200                 205             


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
    210                 215                 220                 


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
225                 230                 235                 240 


Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu Thr Pro Arg Ile Val 
                245                 250                 255     


Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu 
            260                 265                 270         


Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu 
        275                 280                 285             


Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe 
    290                 295                 300                 


Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu 
305                 310                 315                 320 


Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys 
                325                 330                 335     


Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile 
            340                 345                 350         


Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp 
        355                 360                 365             


Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe 
    370                 375                 380                 


Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu 
385                 390                 395                 400 


Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe 
                405                 410                 415     


Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu 
            420                 425                 430         


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys 
        435                 440                 445             


Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala 
    450                 455                 460                 


Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys 
465                 470                 475                 480 


Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser 
                485                 490                 495     


His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
            500                 505             


<210>  23
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protine selon l'invention

<400>  23

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp Met Pro Trp 
        35                  40                  45              


Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu Ala His Gly 
    50                  55                  60                  


Val Leu His Arg Arg Arg Arg Ala Asn Ser Phe Leu Glu Glu Met Lys 
65                  70                  75                  80  


Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu 
                85                  90                  95      


Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp 
            100                 105                 110         


Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
        115                 120                 125             


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
    130                 135                 140                 


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
145                 150                 155                 160 


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
                165                 170                 175     


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
            180                 185                 190         


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
        195                 200                 205             


Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu 
    210                 215                 220                 


Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp 
225                 230                 235                 240 


Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro 
                245                 250                 255     


Glu Arg Gly Asp Asn Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu 
            260                 265                 270         


Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
        275                 280                 285             


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
    290                 295                 300                 


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
305                 310                 315                 320 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
                325                 330                 335     


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
            340                 345                 350         


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
        355                 360                 365             


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
    370                 375                 380                 


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
385                 390                 395                 400 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
                405                 410                 415     


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
            420                 425                 430         


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
        435                 440                 445             


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
    450                 455                 460                 


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
465                 470                 475                 480 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
                485                 490                 495     


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
            500                 505                 510         


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
        515                 520                 525             


Lys 
    


<210>  24
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protine selon l'invention

<400>  24

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Val Phe Val Thr Gln Glu Glu Ala His Gly Val Leu His Arg Arg Arg 
        35                  40                  45              


Arg Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg 
    50                  55                  60                  


Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe 
65                  70                  75                  80  


Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly 
                85                  90                  95      


Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp 
            100                 105                 110         


Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys 
        115                 120                 125             


Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp 
    130                 135                 140                 


Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys 
145                 150                 155                 160 


Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr 
                165                 170                 175     


Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Ser 
            180                 185                 190         


Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile Thr 
        195                 200                 205             


Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro Phe 
    210                 215                 220                 


Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn Asn 
225                 230                 235                 240 


Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu Thr Pro Arg Ile Val Gly 
                245                 250                 255     


Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile 
            260                 265                 270         


Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe 
        275                 280                 285             


Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys 
    290                 295                 300                 


Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala 
305                 310                 315                 320 


Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu 
                325                 330                 335     


Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr 
            340                 345                 350         


Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala 
        355                 360                 365             


Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly 
    370                 375                 380                 


Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu 
385                 390                 395                 400 


Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile 
                405                 410                 415     


Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp 
            420                 425                 430         


Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp 
        435                 440                 445             


Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg 
    450                 455                 460                 


Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp 
465                 470                 475                 480 


Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His 
                485                 490                 495     


Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
            500                 505         


<210>  25
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protine selon l'invention

<400>  25

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Thr 
            20                  25                  30          


Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg Ala His Gln 
        35                  40                  45              


Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu Glu Met Lys 
    50                  55                  60                  


Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu 
65                  70                  75                  80  


Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp 
                85                  90                  95      


Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
            100                 105                 110         


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
        115                 120                 125             


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
    130                 135                 140                 


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
145                 150                 155                 160 


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
                165                 170                 175     


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
            180                 185                 190         


Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu 
        195                 200                 205             


Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp 
    210                 215                 220                 


Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro 
225                 230                 235                 240 


Glu Arg Gly Asp Asn Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu 
                245                 250                 255     


Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
            260                 265                 270         


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
        275                 280                 285             


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
    290                 295                 300                 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
305                 310                 315                 320 


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
                325                 330                 335     


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
            340                 345                 350         


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
        355                 360                 365             


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
    370                 375                 380                 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
385                 390                 395                 400 


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
                405                 410                 415     


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
            420                 425                 430         


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
        435                 440                 445             


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
    450                 455                 460                 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
465                 470                 475                 480 


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
                485                 490                 495     


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
            500                 505                 510         


Lys 
    


<210>  26
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :7

<400>  26
atgggaagac ccctgcatct ggtgctgctg tccgcctcac tggctgggct gctgctgctg       60

ggagaatctc tgtttatccg acgggagcag gca                                    93


<210>  27
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :13

<400>  27
cagcatgtct tcctggcacc acagcaggca cgaagtctgc tgcagcgggt gcggaga          57


<210>  28
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :14

<400>  28
gctggcggcg tcgctaaggc ttctggaggc gagacccggg acatgccctg gaagcctggg       60

ccacatagag tgttcgtgac ccaggaagag gctcatggag tgctgcatag aaggagaagg      120


<210>  29
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :15

<400>  29
gctgtgttcg tgacccagga agaggctcat ggagtgctgc atagaaggag aagg             54


<210>  30
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :16

<400>  30
acacccgccc ctctggatag cgtgttcagc agctctgagc gggcccacca ggtgctgcgg       60

atcagaaaga ga                                                           72


<210>  31
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :17

<400>  31
gccaactctt tcctggagga aatgaagaaa ggccacctgg agcgggaatg catggaggaa       60

acctgtagtt acgaggaagc cagagaggtg ttcgaagact cagataagac aaacgagttt      120

tggaataagt acaaagacgg cgatcagtgc gaaactagcc catgtcagaa ccaggggaag      180

tgcaaagatg gactgggcga gtacacctgc acatgtctgg agggattcga aggcaagaat      240

tgcgaactgt ttaccagaaa gctgtgctcc ctggataacg gcgactgcga tcagttttgt      300

catgaggaac agaattccgt ggtctgctct tgtgccaggg gatacacact ggctgacaat      360

ggcaaggcat gcatccccac cggcccctat ccttgtggga agcagacact ggagaggcgc      420

aaaaggtcag tggctcaggc aactagctcc tctggcgagg cccccgatag cattacctgg      480

aaaccttatg acgccgctga cctggacccc acagagaacc cctttgacct gctggacttc      540

aaccagacac agcctgaaag aggcgataac aatctgacta gggacttcct ggccgagggc      600

ctgaccccta ggatcgtggg aggacaggag tgcaaggacg gagaatgtcc atggcaggcc      660

ctgctgatta acgaggaaaa tgagggattc tgcggaggca ctatcctgag cgagttctac      720

attctgaccg cagcccactg tctgtatcag gctaagcgat tcaaagtgcg ggtcggcgac      780

agaaacaccg agcaggagga agggggagaa gcagtgcacg aggtcgaagt ggtcatcaag      840

cataatcgct tcactaaaga gacctacgac tttgatatcg ctgtgctgcg cctgaagaca      900

cctattactt tccgaatgaa cgtcgcccct gcttgcctgc cagagcgaga ttgggccgaa      960

agcaccctga tgacacagaa aactggcatc gtgagcgggt ttggacggac acatgagaag     1020

ggcaggcagt ccactcgcct gaaaatgctg gaagtgccct acgtcgaccg gaactcttgt     1080

aagctgagta gcagcttcat cattacccag aatatgtttt gcgccgggta tgacacaaag     1140

caggaggatg cttgtcaggg agacagtggc gggcctcacg tgactaggtt caaagatact     1200

tattttgtga ccggcatcgt cagctgggga gagggatgcg cacgcaaggg gaaatacgga     1260

atctatacca aggtgacagc ctttctgaaa tggattgacc gatctatgaa gacccggggg     1320

ctgccaaagg caaaaagtca tgcccccgag gtcattacca gttcccctct gaaa           1374


<210>  32
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :22

<400>  32
atgggaagac ccctgcatct ggtgctgctg tccgcctcac tggctgggct gctgctgctg       60

ggagaatctc tgtttatccg acgggagcag gcacagcatg tcttcctggc accacagcag      120

gcacgaagtc tgctgcagcg ggtgcggaga gccaactctt tcctggagga aatgaagaaa      180

ggccacctgg agcgggaatg catggaggaa acctgtagtt acgaggaagc cagagaggtg      240

ttcgaagact cagataagac aaacgagttt tggaataagt acaaagacgg cgatcagtgc      300

gaaactagcc catgtcagaa ccaggggaag tgcaaagatg gactgggcga gtacacctgc      360

acatgtctgg agggattcga aggcaagaat tgcgaactgt ttaccagaaa gctgtgctcc      420

ctggataacg gcgactgcga tcagttttgt catgaggaac agaattccgt ggtctgctct      480

tgtgccaggg gatacacact ggctgacaat ggcaaggcat gcatccccac cggcccctat      540

ccttgtggga agcagacact ggagaggcgc aaaaggtcag tggctcaggc aactagctcc      600

tctggcgagg cccccgatag cattacctgg aaaccttatg acgccgctga cctggacccc      660

acagagaacc cctttgacct gctggacttc aaccagacac agcctgaaag aggcgataac      720

aatctgacta gggacttcct ggccgagggc ctgaccccta ggatcgtggg aggacaggag      780

tgcaaggacg gagaatgtcc atggcaggcc ctgctgatta acgaggaaaa tgagggattc      840

tgcggaggca ctatcctgag cgagttctac attctgaccg cagcccactg tctgtatcag      900

gctaagcgat tcaaagtgcg ggtcggcgac agaaacaccg agcaggagga agggggagaa      960

gcagtgcacg aggtcgaagt ggtcatcaag cataatcgct tcactaaaga gacctacgac     1020

tttgatatcg ctgtgctgcg cctgaagaca cctattactt tccgaatgaa cgtcgcccct     1080

gcttgcctgc cagagcgaga ttgggccgaa agcaccctga tgacacagaa aactggcatc     1140

gtgagcgggt ttggacggac acatgagaag ggcaggcagt ccactcgcct gaaaatgctg     1200

gaagtgccct acgtcgaccg gaactcttgt aagctgagta gcagcttcat cattacccag     1260

aatatgtttt gcgccgggta tgacacaaag caggaggatg cttgtcaggg agacagtggc     1320

gggcctcacg tgactaggtt caaagatact tattttgtga ccggcatcgt cagctgggga     1380

gagggatgcg cacgcaaggg gaaatacgga atctatacca aggtgacagc ctttctgaaa     1440

tggattgacc gatctatgaa gacccggggg ctgccaaagg caaaaagtca tgcccccgag     1500

gtcattacca gttcccctct gaaa                                            1524


<210>  33
<211>  1587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :23

<400>  33
atgggaagac ccctgcatct ggtgctgctg tccgcctcac tggctgggct gctgctgctg       60

ggagaatctc tgtttatccg acgggagcag gcagctggcg gcgtcgctaa ggcttctgga      120

ggcgagaccc gggacatgcc ctggaagcct gggccacata gagtgttcgt gacccaggaa      180

gaggctcatg gagtgctgca tagaaggaga agggccaact ctttcctgga ggaaatgaag      240

aaaggccacc tggagcggga atgcatggag gaaacctgta gttacgagga agccagagag      300

gtgttcgaag actcagataa gacaaacgag ttttggaata agtacaaaga cggcgatcag      360

tgcgaaacta gcccatgtca gaaccagggg aagtgcaaag atggactggg cgagtacacc      420

tgcacatgtc tggagggatt cgaaggcaag aattgcgaac tgtttaccag aaagctgtgc      480

tccctggata acggcgactg cgatcagttt tgtcatgagg aacagaattc cgtggtctgc      540

tcttgtgcca ggggatacac actggctgac aatggcaagg catgcatccc caccggcccc      600

tatccttgtg ggaagcagac actggagagg cgcaaaaggt cagtggctca ggcaactagc      660

tcctctggcg aggcccccga tagcattacc tggaaacctt atgacgccgc tgacctggac      720

cccacagaga acccctttga cctgctggac ttcaaccaga cacagcctga aagaggcgat      780

aacaatctga ctagggactt cctggccgag ggcctgaccc ctaggatcgt gggaggacag      840

gagtgcaagg acggagaatg tccatggcag gccctgctga ttaacgagga aaatgaggga      900

ttctgcggag gcactatcct gagcgagttc tacattctga ccgcagccca ctgtctgtat      960

caggctaagc gattcaaagt gcgggtcggc gacagaaaca ccgagcagga ggaaggggga     1020

gaagcagtgc acgaggtcga agtggtcatc aagcataatc gcttcactaa agagacctac     1080

gactttgata tcgctgtgct gcgcctgaag acacctatta ctttccgaat gaacgtcgcc     1140

cctgcttgcc tgccagagcg agattgggcc gaaagcaccc tgatgacaca gaaaactggc     1200

atcgtgagcg ggtttggacg gacacatgag aagggcaggc agtccactcg cctgaaaatg     1260

ctggaagtgc cctacgtcga ccggaactct tgtaagctga gtagcagctt catcattacc     1320

cagaatatgt tttgcgccgg gtatgacaca aagcaggagg atgcttgtca gggagacagt     1380

ggcgggcctc acgtgactag gttcaaagat acttattttg tgaccggcat cgtcagctgg     1440

ggagagggat gcgcacgcaa ggggaaatac ggaatctata ccaaggtgac agcctttctg     1500

aaatggattg accgatctat gaagacccgg gggctgccaa aggcaaaaag tcatgccccc     1560

gaggtcatta ccagttcccc tctgaaa                                         1587


<210>  34
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :24

<400>  34
atgggaagac ccctgcatct ggtgctgctg tccgcctcac tggctgggct gctgctgctg       60

ggagaatctc tgtttatccg acgggagcag gcagctgtgt tcgtgaccca ggaagaggct      120

catggagtgc tgcatagaag gagaagggcc aactctttcc tggaggaaat gaagaaaggc      180

cacctggagc gggaatgcat ggaggaaacc tgtagttacg aggaagccag agaggtgttc      240

gaagactcag ataagacaaa cgagttttgg aataagtaca aagacggcga tcagtgcgaa      300

actagcccat gtcagaacca ggggaagtgc aaagatggac tgggcgagta cacctgcaca      360

tgtctggagg gattcgaagg caagaattgc gaactgttta ccagaaagct gtgctccctg      420

gataacggcg actgcgatca gttttgtcat gaggaacaga attccgtggt ctgctcttgt      480

gccaggggat acacactggc tgacaatggc aaggcatgca tccccaccgg cccctatcct      540

tgtgggaagc agacactgga gaggcgcaaa aggtcagtgg ctcaggcaac tagctcctct      600

ggcgaggccc ccgatagcat tacctggaaa ccttatgacg ccgctgacct ggaccccaca      660

gagaacccct ttgacctgct ggacttcaac cagacacagc ctgaaagagg cgataacaat      720

ctgactaggg acttcctggc cgagggcctg acccctagga tcgtgggagg acaggagtgc      780

aaggacggag aatgtccatg gcaggccctg ctgattaacg aggaaaatga gggattctgc      840

ggaggcacta tcctgagcga gttctacatt ctgaccgcag cccactgtct gtatcaggct      900

aagcgattca aagtgcgggt cggcgacaga aacaccgagc aggaggaagg gggagaagca      960

gtgcacgagg tcgaagtggt catcaagcat aatcgcttca ctaaagagac ctacgacttt     1020

gatatcgctg tgctgcgcct gaagacacct attactttcc gaatgaacgt cgcccctgct     1080

tgcctgccag agcgagattg ggccgaaagc accctgatga cacagaaaac tggcatcgtg     1140

agcgggtttg gacggacaca tgagaagggc aggcagtcca ctcgcctgaa aatgctggaa     1200

gtgccctacg tcgaccggaa ctcttgtaag ctgagtagca gcttcatcat tacccagaat     1260

atgttttgcg ccgggtatga cacaaagcag gaggatgctt gtcagggaga cagtggcggg     1320

cctcacgtga ctaggttcaa agatacttat tttgtgaccg gcatcgtcag ctggggagag     1380

ggatgcgcac gcaaggggaa atacggaatc tataccaagg tgacagcctt tctgaaatgg     1440

attgaccgat ctatgaagac ccgggggctg ccaaaggcaa aaagtcatgc ccccgaggtc     1500

attaccagtt cccctctgaa a                                               1521


<210>  35
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour SEQ ID NO :25

<400>  35
atgggaagac ccctgcatct ggtgctgctg tccgcctcac tggctgggct gctgctgctg       60

ggagaatctc tgtttatccg acgggagcag gcaacacccg cccctctgga tagcgtgttc      120

agcagctctg agcgggccca ccaggtgctg cggatcagaa agagagccaa ctctttcctg      180

gaggaaatga agaaaggcca cctggagcgg gaatgcatgg aggaaacctg tagttacgag      240

gaagccagag aggtgttcga agactcagat aagacaaacg agttttggaa taagtacaaa      300

gacggcgatc agtgcgaaac tagcccatgt cagaaccagg ggaagtgcaa agatggactg      360

ggcgagtaca cctgcacatg tctggaggga ttcgaaggca agaattgcga actgtttacc      420

agaaagctgt gctccctgga taacggcgac tgcgatcagt tttgtcatga ggaacagaat      480

tccgtggtct gctcttgtgc caggggatac acactggctg acaatggcaa ggcatgcatc      540

cccaccggcc cctatccttg tgggaagcag acactggaga ggcgcaaaag gtcagtggct      600

caggcaacta gctcctctgg cgaggccccc gatagcatta cctggaaacc ttatgacgcc      660

gctgacctgg accccacaga gaaccccttt gacctgctgg acttcaacca gacacagcct      720

gaaagaggcg ataacaatct gactagggac ttcctggccg agggcctgac ccctaggatc      780

gtgggaggac aggagtgcaa ggacggagaa tgtccatggc aggccctgct gattaacgag      840

gaaaatgagg gattctgcgg aggcactatc ctgagcgagt tctacattct gaccgcagcc      900

cactgtctgt atcaggctaa gcgattcaaa gtgcgggtcg gcgacagaaa caccgagcag      960

gaggaagggg gagaagcagt gcacgaggtc gaagtggtca tcaagcataa tcgcttcact     1020

aaagagacct acgactttga tatcgctgtg ctgcgcctga agacacctat tactttccga     1080

atgaacgtcg cccctgcttg cctgccagag cgagattggg ccgaaagcac cctgatgaca     1140

cagaaaactg gcatcgtgag cgggtttgga cggacacatg agaagggcag gcagtccact     1200

cgcctgaaaa tgctggaagt gccctacgtc gaccggaact cttgtaagct gagtagcagc     1260

ttcatcatta cccagaatat gttttgcgcc gggtatgaca caaagcagga ggatgcttgt     1320

cagggagaca gtggcgggcc tcacgtgact aggttcaaag atacttattt tgtgaccggc     1380

atcgtcagct ggggagaggg atgcgcacgc aaggggaaat acggaatcta taccaaggtg     1440

acagcctttc tgaaatggat tgaccgatct atgaagaccc gggggctgcc aaaggcaaaa     1500

agtcatgccc ccgaggtcat taccagttcc cctctgaaa                            1539


<210>  36
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  37
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  40
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine SEQ ID NO :23 fusionne au fragment Fc sauvage SEQ ID NO 
       :36, ventuellement suivie d'une lysine

<400>  40

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp Met Pro Trp 
        35                  40                  45              


Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu Ala His Gly 
    50                  55                  60                  


Val Leu His Arg Arg Arg Arg Ala Asn Ser Phe Leu Glu Glu Met Lys 
65                  70                  75                  80  


Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu 
                85                  90                  95      


Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp 
            100                 105                 110         


Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
        115                 120                 125             


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
    130                 135                 140                 


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
145                 150                 155                 160 


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
                165                 170                 175     


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
            180                 185                 190         


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
        195                 200                 205             


Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu 
    210                 215                 220                 


Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp 
225                 230                 235                 240 


Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro 
                245                 250                 255     


Glu Arg Gly Asp Asn Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu 
            260                 265                 270         


Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
        275                 280                 285             


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
    290                 295                 300                 


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
305                 310                 315                 320 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
                325                 330                 335     


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
            340                 345                 350         


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
        355                 360                 365             


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
    370                 375                 380                 


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
385                 390                 395                 400 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
                405                 410                 415     


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
            420                 425                 430         


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
        435                 440                 445             


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
    450                 455                 460                 


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
465                 470                 475                 480 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
                485                 490                 495     


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
            500                 505                 510         


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
        515                 520                 525             


Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    530                 535                 540                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
545                 550                 555                 560 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                565                 570                 575     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            580                 585                 590         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        595                 600                 605             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    610                 615                 620                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
625                 630                 635                 640 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                645                 650                 655     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            660                 665                 670         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        675                 680                 685             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    690                 695                 700                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
705                 710                 715                 720 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                725                 730                 735     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            740                 745                 750         


Ser Pro Gly 
        755 


<210>  41
<211>  2265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Acide nuclique codant pour la protine SEQ ID NO :40, 
       ventuellement suivi d'un codon codant pour une lysine

<400>  41
atgggaagac ccctgcatct ggtgctgctg tccgcctcac tggctgggct gctgctgctg       60

ggagaatctc tgtttatccg acgggagcag gcagctggcg gcgtcgctaa ggcttctgga      120

ggcgagaccc gggacatgcc ctggaagcct gggccacata gagtgttcgt gacccaggaa      180

gaggctcatg gagtgctgca tagaaggaga agggccaact ctttcctgga ggaaatgaag      240

aaaggccacc tggagcggga atgcatggag gaaacctgta gttacgagga agccagagag      300

gtgttcgaag actcagataa gacaaacgag ttttggaata agtacaaaga cggcgatcag      360

tgcgaaacta gcccatgtca gaaccagggg aagtgcaaag atggactggg cgagtacacc      420

tgcacatgtc tggagggatt cgaaggcaag aattgcgaac tgtttaccag aaagctgtgc      480

tccctggata acggcgactg cgatcagttt tgtcatgagg aacagaattc cgtggtctgc      540

tcttgtgcca ggggatacac actggctgac aatggcaagg catgcatccc caccggcccc      600

tatccttgtg ggaagcagac actggagagg cgcaaaaggt cagtggctca ggcaactagc      660

tcctctggcg aggcccccga tagcattacc tggaaacctt atgacgccgc tgacctggac      720

cccacagaga acccctttga cctgctggac ttcaaccaga cacagcctga aagaggcgat      780

aacaatctga ctagggactt cctggccgag ggcctgaccc ctaggatcgt gggaggacag      840

gagtgcaagg acggagaatg tccatggcag gccctgctga ttaacgagga aaatgaggga      900

ttctgcggag gcactatcct gagcgagttc tacattctga ccgcagccca ctgtctgtat      960

caggctaagc gattcaaagt gcgggtcggc gacagaaaca ccgagcagga ggaaggggga     1020

gaagcagtgc acgaggtcga agtggtcatc aagcataatc gcttcactaa agagacctac     1080

gactttgata tcgctgtgct gcgcctgaag acacctatta ctttccgaat gaacgtcgcc     1140

cctgcttgcc tgccagagcg agattgggcc gaaagcaccc tgatgacaca gaaaactggc     1200

atcgtgagcg ggtttggacg gacacatgag aagggcaggc agtccactcg cctgaaaatg     1260

ctggaagtgc cctacgtcga ccggaactct tgtaagctga gtagcagctt catcattacc     1320

cagaatatgt tttgcgccgg gtatgacaca aagcaggagg atgcttgtca gggagacagt     1380

ggcgggcctc acgtgactag gttcaaagat acttattttg tgaccggcat cgtcagctgg     1440

ggagagggat gcgcacgcaa ggggaaatac ggaatctata ccaaggtgac agcctttctg     1500

aaatggattg accgatctat gaagacccgg gggctgccaa aggcaaaaag tcatgccccc     1560

gaggtcatta ccagttcccc tctgaaagac aaaacccata catgcccacc ttgtccagca     1620

cctgaactgc tgggaggacc atccgtgttc ctgtttccac ccaagcccaa agatacactg     1680

atgattagtc ggacccctga ggtgacatgc gtggtcgtgg atgtctcaca cgaggaccca     1740

gaagtgaagt ttaactggta cgtggacggc gtggaagtcc ataatgccaa gaccaaacct     1800

cgcgaggaac agtacaacag tacatatcga gtcgtgtcag tgctgactgt cctgcaccag     1860

gattggctga acggaaagga gtataagtgc aaagtgagca ataaggctct gccagcaccc     1920

atcgagaaaa caatttccaa ggcaaaaggc cagccaaggg aaccccaggt gtacactctg     1980

cctccaagcc gcgatgagct gacaaagaac caggtgtccc tgacttgtct ggtcaaaggg     2040

ttctatccct ccgacatcgc cgtggagtgg gaatctaatg gacagcctga gaacaattac     2100

aagaccacac cccctgtgct ggactcagat gggagcttct ttctgtattc taagctgact     2160

gtggacaaaa gtagatggca gcagggaaac gtgttttctt gcagtgtcat gcacgaggcc     2220

ctgcacaatc attacaccca gaagtcactg agcctgtccc cagga                     2265


<210>  42
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFc

<400>  42

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460         


<210>  43
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine SEQ ID NO :23 fusionne au fragment scFc sauvage SEQ ID NO
       :42, ventuellement suivie d'une lysine

<400>  43

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp Met Pro Trp 
        35                  40                  45              


Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu Ala His Gly 
    50                  55                  60                  


Val Leu His Arg Arg Arg Arg Ala Asn Ser Phe Leu Glu Glu Met Lys 
65                  70                  75                  80  


Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu 
                85                  90                  95      


Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp 
            100                 105                 110         


Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
        115                 120                 125             


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
    130                 135                 140                 


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
145                 150                 155                 160 


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
                165                 170                 175     


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
            180                 185                 190         


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
        195                 200                 205             


Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu 
    210                 215                 220                 


Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp 
225                 230                 235                 240 


Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro 
                245                 250                 255     


Glu Arg Gly Asp Asn Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu 
            260                 265                 270         


Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
        275                 280                 285             


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
    290                 295                 300                 


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
305                 310                 315                 320 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
                325                 330                 335     


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
            340                 345                 350         


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
        355                 360                 365             


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
    370                 375                 380                 


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
385                 390                 395                 400 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
                405                 410                 415     


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
            420                 425                 430         


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
        435                 440                 445             


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
    450                 455                 460                 


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
465                 470                 475                 480 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
                485                 490                 495     


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
            500                 505                 510         


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
        515                 520                 525             


Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    530                 535                 540                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
545                 550                 555                 560 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                565                 570                 575     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            580                 585                 590         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        595                 600                 605             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    610                 615                 620                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
625                 630                 635                 640 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                645                 650                 655     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            660                 665                 670         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        675                 680                 685             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    690                 695                 700                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
705                 710                 715                 720 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                725                 730                 735     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            740                 745                 750         


Ser Pro Gly Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
        755                 760                 765             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    770                 775                 780                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
785                 790                 795                 800 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                805                 810                 815     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            820                 825                 830         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        835                 840                 845             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    850                 855                 860                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
865                 870                 875                 880 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                885                 890                 895     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            900                 905                 910         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        915                 920                 925             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    930                 935                 940                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
945                 950                 955                 960 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                965                 970                 975     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            980                 985                 990     


<210>  44
<211>  2973
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Acide nuclique codant pour la protine SEQ ID NO :43

<400>  44
atgggaagac ccctgcatct ggtgctgctg tccgcctcac tggctgggct gctgctgctg       60

ggagaatctc tgtttatccg acgggagcag gcagctggcg gcgtcgctaa ggcttctgga      120

ggcgagaccc gggacatgcc ctggaagcct gggccacata gagtgttcgt gacccaggaa      180

gaggctcatg gagtgctgca tagaaggaga agggccaact ctttcctgga ggaaatgaag      240

aaaggccacc tggagcggga atgcatggag gaaacctgta gttacgagga agccagagag      300

gtgttcgaag actcagataa gacaaacgag ttttggaata agtacaaaga cggcgatcag      360

tgcgaaacta gcccatgtca gaaccagggg aagtgcaaag atggactggg cgagtacacc      420

tgcacatgtc tggagggatt cgaaggcaag aattgcgaac tgtttaccag aaagctgtgc      480

tccctggata acggcgactg cgatcagttt tgtcatgagg aacagaattc cgtggtctgc      540

tcttgtgcca ggggatacac actggctgac aatggcaagg catgcatccc caccggcccc      600

tatccttgtg ggaagcagac actggagagg cgcaaaaggt cagtggctca ggcaactagc      660

tcctctggcg aggcccccga tagcattacc tggaaacctt atgacgccgc tgacctggac      720

cccacagaga acccctttga cctgctggac ttcaaccaga cacagcctga aagaggcgat      780

aacaatctga ctagggactt cctggccgag ggcctgaccc ctaggatcgt gggaggacag      840

gagtgcaagg acggagaatg tccatggcag gccctgctga ttaacgagga aaatgaggga      900

ttctgcggag gcactatcct gagcgagttc tacattctga ccgcagccca ctgtctgtat      960

caggctaagc gattcaaagt gcgggtcggc gacagaaaca ccgagcagga ggaaggggga     1020

gaagcagtgc acgaggtcga agtggtcatc aagcataatc gcttcactaa agagacctac     1080

gactttgata tcgctgtgct gcgcctgaag acacctatta ctttccgaat gaacgtcgcc     1140

cctgcttgcc tgccagagcg agattgggcc gaaagcaccc tgatgacaca gaaaactggc     1200

atcgtgagcg ggtttggacg gacacatgag aagggcaggc agtccactcg cctgaaaatg     1260

ctggaagtgc cctacgtcga ccggaactct tgtaagctga gtagcagctt catcattacc     1320

cagaatatgt tttgcgccgg gtatgacaca aagcaggagg atgcttgtca gggagacagt     1380

ggcgggcctc acgtgactag gttcaaagat acttattttg tgaccggcat cgtcagctgg     1440

ggagagggat gcgcacgcaa ggggaaatac ggaatctata ccaaggtgac agcctttctg     1500

aaatggattg accgatctat gaagacccgg gggctgccaa aggcaaaaag tcatgccccc     1560

gaggtcatta ccagttcccc tctgaaagac aaaacccata catgcccacc ttgtccagca     1620

cctgaactgc tgggaggacc atccgtgttc ctgtttccac ccaagcccaa agatacactg     1680

atgattagtc ggacccctga ggtgacatgc gtggtcgtgg atgtctcaca cgaggaccca     1740

gaagtgaagt ttaactggta cgtggacggc gtggaagtcc ataatgccaa gaccaaacct     1800

cgcgaggaac agtacaacag tacatatcga gtcgtgtcag tgctgactgt cctgcaccag     1860

gattggctga acggaaagga gtataagtgc aaagtgagca ataaggctct gccagcaccc     1920

atcgagaaaa caatttccaa ggcaaaaggc cagccaaggg aaccccaggt gtacactctg     1980

cctccaagcc gcgatgagct gacaaagaac caggtgtccc tgacttgtct ggtcaaaggg     2040

ttctatccct ccgacatcgc cgtggagtgg gaatctaatg gacagcctga gaacaattac     2100

aagaccacac cccctgtgct ggactcagat gggagcttct ttctgtattc taagctgact     2160

gtggacaaaa gtagatggca gcagggaaac gtgttttctt gcagtgtcat gcacgaggcc     2220

ctgcacaatc attacaccca gaagtcactg agcctgtccc caggaggagg aggaggaagc     2280

gagcccaaga gctccgataa aactcatacc tgcccaccct gtcctgctcc agaactgctg     2340

ggaggcccta gcgtgttcct gtttcctcca aagccaaaag acacactgat gatttctagg     2400

actcccgagg tgacctgcgt ggtggtcgat gtcagtcacg aggaccctga agtgaagttc     2460

aactggtacg tggatggagt cgaggtgcac aacgccaaga ccaaaccccg ggaggaacag     2520

tacaacagca cctatagagt ggtctccgtg ctgacagtcc tgcaccagga ctggctgaac     2580

gggaaggaat acaagtgcaa agtgtccaat aaggccctgc ccgctcctat cgaaaaaacc     2640

atttctaagg ctaaaggcca gccccgggag ccacaggtgt acacactgcc cccttctcgg     2700

gatgaactga ccaagaacca ggtgagtctg acatgtctgg tcaaaggctt ctatccaagt     2760

gacatcgcag tggagtggga atcaaatggg cagcccgaga acaattacaa gactacccca     2820

cccgtgctgg actccgatgg ctctttcttt ctgtattcaa agctgaccgt ggacaaaagc     2880

agatggcagc aggggaacgt gttcagctgc agtgtcatgc acgaagcact gcacaatcat     2940

tacactcaga aatcactgtc actgtcacct gga                                  2973


<210>  45
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gly Ser Thr Trp Gly Ser Pro Gly Trp Val Arg Leu Ala Leu Cys 
1               5                   10                  15      


Leu Thr Gly Leu Val Leu Ser Leu Tyr Ala Leu His Val Lys Ala Ala 
            20                  25                  30          


Arg Ala Arg Asp Arg Asp Tyr Arg Ala Leu Cys Asp Val Gly Thr Ala 
        35                  40                  45              


Ile Ser Cys Ser Arg Val Phe Ser Ser Arg Trp Gly Arg Gly Phe Gly 
    50                  55                  60                  


Leu Val Glu His Val Leu Gly Gln Asp Ser Ile Leu Asn Gln Ser Asn 
65                  70                  75                  80  


Ser Ile Phe Gly Cys Ile Phe Tyr Thr Leu Gln Leu Leu Leu Gly Cys 
                85                  90                  95      


Leu Arg Thr Arg Trp Ala Ser Val Leu Met Leu Leu Ser Ser Leu Val 
            100                 105                 110         


Ser Leu Ala Gly Ser Val Tyr Leu Ala Trp Ile Leu Phe Phe Val Leu 
        115                 120                 125             


Tyr Asp Phe Cys Ile Val Cys Ile Thr Thr Tyr Ala Ile Asn Val Ser 
    130                 135                 140                 


Leu Met Trp Leu Ser Phe Arg Lys Val Gln Glu Pro Gln Gly Lys Ala 
145                 150                 155                 160 


Lys Arg 
        


<210>  46
<211>  486
<212>  DNA
<213>  Homo sapiens

<400>  46
atgggatcaa catgggggtc acctggctgg gtccgactgg ccctgtgcct gactggactg       60

gtcctgtctc tgtatgccct gcacgtcaag gccgctcggg ctagagacag ggattatcgc      120

gcactgtgcg acgtgggaac agccatctca tgtagcaggg tcttcagctc ccggtggggc      180

agagggtttg gactggtgga gcacgtcctg ggccaggata gcattctgaa ccagtccaat      240

tctatcttcg gctgcatctt ctacactctg cagctgctgc tgggatgtct gcgaacccga      300

tgggcttccg tgctgatgct gctgtctagt ctggtgagtc tggcagggtc agtctacctg      360

gcctggattc tgttcttcgt gctgtatgac ttctgcatcg tctgtattac cacatacgcc      420

attaacgtgt ctctgatgtg gctgtcattc agaaaggtcc aggaacccca gggaaaggca      480

aaaagg                                                                 486


<210>  47
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser 
            20                  


<210>  48
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala 
            20  


<210>  49
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly 
        


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  50
accagctgct agcaagcttg ccg                                               23


<210>  51
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51
gtcaggccct cggccaggaa gtccctagtc agattgttat cgcctctttc aggc             54


<210>  52
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
agggcctgac ccctaggatc gtgggaggac aggagtgcaa gga                         43


<210>  53
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
gaaactattt aaatggatcc tcacttgccg tcaatcagc                              39


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
ggtggcggca agcttgctag c                                                 21


<210>  55
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
ccttgggcaa taaatactag tggcgttac                                         29


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
aagcttgccg ccaccatggc tcacgtccga gggctg                                 36


<210>  57
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  57
cttcatttcc tccaggaaag agttggctct ccgcacccgc tgcagc                      46


<210>  58
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  58
aagcttgccg ccaccatggt gtctcaggct ctgcggc                                37


<210>  59
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  59
caggaaagag ttggcccttc tccttctatg cagcactcca tg                          42


<210>  60
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  60
aagcttgccg ccaccatggt gtctcaggct ctgcggc                                37


<210>  61
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  61
gtcacgaaca cagcagccag acatccctgc agtc                                   34


<210>  62
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
aagcttgccg ccaccatgtg gcagctgacc agcctgctgc tgttcgtggc cacatg           56


<210>  63
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
gagctgctga acacgctatc cagaggggcg ggtgtgccag agatgcccca tgtggccacg       60


<210>  64
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
ttcagcagct ctgagcgggc ccaccaggtg ctgcggatca gaaagagagc caactctttc       60


<210>  65
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
gccaactctt tcctggagga aatgaag                                           27


<210>  66
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
agctctagac aattgattta aatggatcct cac                                    33


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  67
gtggagactg aagttaggcc ag                                                22


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  68
gtggagactg aagttaggcc ag                                                22


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  69
ggaggcacta tcctgagcga g                                                 21


<210>  70
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  70
agctctagac aattgattta aatggatcct cac                                    33


<210>  71
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  71
gacgggagca ggcccagcat gtcttcctgg caccacag                               38


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  72
agctctagac aattgattta aatggatcct cac                                    33


<210>  73
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  73
cgggagcagg ccgctggcgg cgtcgctaag gc                                     32


<210>  74
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  74
agctctagac aattgattta aatggatcct cac                                    33


<210>  75
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  75
cgggagcagg ccgctgtgtt cgtgacccag gaagag                                 36


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  76
agctctagac aattgattta aatggatcct cac                                    33


<210>  77
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  77
cgggagcagg ccacacccgc ccctctggat agcg                                   34


<210>  78
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  78
gtggagactg aagttaggcc ag                                                22


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  79
gtggagactg aagttaggcc ag                                                22


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  80
ggaggcacta tcctgagcga g                                                 21


<210>  81
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  82
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence d'acide nuclique optimise codant pour la protine SEQ ID 
       NO :40

<400>  82
atgggcagac ctctgcacct ggtgctgctg tctgcctctc tggctggact gctgctgctg       60

ggcgagagcc tgttcatcag aagagagcag gccgctggcg gagtggccaa agcttctggc      120

ggcgagacaa gagacatgcc ctggaagcct ggcccccaca gagtgttcgt gacccaggaa      180

gaggcccacg gcgtgctgca cagaagaaga agggccaaca gcttcctgga agagatgaag      240

aagggacacc tggaacgcga gtgcatggaa gaaacctgca gctacgaaga ggccagagaa      300

gtgttcgagg acagcgacaa gaccaacgag ttctggaaca agtacaagga cggcgaccag      360

tgcgaaacca gcccctgcca gaatcagggc aagtgcaagg atggcctggg cgagtacacc      420

tgtacctgcc tggaaggctt tgagggcaag aactgcgagc tgttcacccg gaagctgtgc      480

agcctggaca acggcgactg cgaccagttc tgccacgagg aacagaacag cgtcgtgtgc      540

agctgcgcca gaggctacac cctggccgat aatggcaagg cctgcatccc caccggccct      600

tacccttgtg gcaagcagac cctggaacgg cggaagagat ctgtggccca ggctacaagc      660

agcagcggcg aggcccctga tagcatcaca tggaagccct acgacgccgc cgacctggac      720

cctaccgaga accctttcga cctgctggac ttcaaccaga cccagcccga gcggggcgac      780

aacaacctga ccagagattt cctggccgag ggcctgaccc ccagaatcgt gggaggacag      840

gaatgcaagg acggggagtg tccttggcag gccctgctga tcaacgagga aaacgagggc      900

ttctgcggcg gcaccatcct gagcgagttc tacatcctga cagccgccca ctgcctgtac      960

caggccaagc ggttcaaagt gcgcgtgggc gacagaaaca ccgagcagga agagggcgga     1020

gaggccgtgc acgaagtgga agtcgtgatc aagcacaacc ggttcaccaa agagacatac     1080

gacttcgaca ttgccgtgct gcggctgaaa acccccatca ccttccggat gaacgtggcc     1140

cctgcctgtc tgcccgaaag agattgggcc gagagcaccc tgatgaccca gaaaaccggc     1200

atcgtgtccg gcttcggccg gacacacgaa aagggccggc agagcacccg gctgaagatg     1260

ctggaagtgc cctacgtgga ccggaacagc tgcaagctga gcagcagctt catcatcacc     1320

cagaatatgt tctgcgccgg ctacgacacc aaacaggaag atgcctgcca gggcgactct     1380

ggcggacctc acgtgaccag attcaaggac acctacttcg tgacagggat cgtgtcctgg     1440

ggcgagggct gtgccagaaa ggggaagtac ggcatctata ccaaagtgac cgccttcctg     1500

aagtggatcg accggtccat gaagaccagg ggactgccca aggccaagag ccacgcccct     1560

gaagtgatca ccagcagccc cctgaaggac aagacccaca cctgtccccc ttgccctgcc     1620

cctgaactgc tgggaggccc tagcgtgttc ctgttccccc caaagcccaa ggatacactg     1680

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccca     1740

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc     1800

agagaggaac agtacaactc cacctaccgg gtggtgtccg tgctgacagt gctgcaccag     1860

gactggctga acggcaaaga gtacaagtgc aaagtgtcca acaaggccct gcctgccccc     1920

atcgagaaaa ccatctctaa ggccaaggga cagccccgcg agccccaggt gtacacactg     1980

cctccaagca gggacgagct gaccaagaat caggtgtcac tgacctgtct cgtgaagggc     2040

ttctacccca gcgatattgc cgtggaatgg gagagcaacg gccagcctga gaacaactac     2100

aagaccaccc cccctgtgct ggactccgac ggctcattct tcctgtacag caagctgacc     2160

gtggacaaga gccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     2220

ctgcacaacc actacacaca gaagtccctg agcctgagcc ccggctga                  2268


<210>  83
<211>  1509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine SEQ ID NO :23, fusionne  SEQ ID NO: 36, fusionne un 
       linker (GSSG)8 fusionne  SEQ ID NO: 14, fusionne  SEQ ID NO: 17 
       fusionne  SEQ ID NO: 36

<400>  83

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp Met Pro Trp 
        35                  40                  45              


Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu Ala His Gly 
    50                  55                  60                  


Val Leu His Arg Arg Arg Arg Ala Asn Ser Phe Leu Glu Glu Met Lys 
65                  70                  75                  80  


Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu 
                85                  90                  95      


Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp 
            100                 105                 110         


Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
        115                 120                 125             


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
    130                 135                 140                 


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
145                 150                 155                 160 


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
                165                 170                 175     


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
            180                 185                 190         


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
        195                 200                 205             


Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu 
    210                 215                 220                 


Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp 
225                 230                 235                 240 


Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro 
                245                 250                 255     


Glu Arg Gly Asp Asn Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu 
            260                 265                 270         


Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
        275                 280                 285             


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
    290                 295                 300                 


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
305                 310                 315                 320 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
                325                 330                 335     


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
            340                 345                 350         


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
        355                 360                 365             


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
    370                 375                 380                 


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
385                 390                 395                 400 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
                405                 410                 415     


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
            420                 425                 430         


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
        435                 440                 445             


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
    450                 455                 460                 


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
465                 470                 475                 480 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
                485                 490                 495     


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
            500                 505                 510         


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
        515                 520                 525             


Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    530                 535                 540                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
545                 550                 555                 560 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                565                 570                 575     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            580                 585                 590         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        595                 600                 605             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    610                 615                 620                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
625                 630                 635                 640 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                645                 650                 655     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            660                 665                 670         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        675                 680                 685             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    690                 695                 700                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
705                 710                 715                 720 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                725                 730                 735     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            740                 745                 750         


Ser Pro Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        755                 760                 765             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    770                 775                 780                 


Ser Gly Ala Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp 
785                 790                 795                 800 


Met Pro Trp Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu 
                805                 810                 815     


Ala His Gly Val Leu His Arg Arg Arg Arg Ala Asn Ser Phe Leu Glu 
            820                 825                 830         


Glu Met Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys 
        835                 840                 845             


Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn 
    850                 855                 860                 


Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro 
865                 870                 875                 880 


Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys 
                885                 890                 895     


Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg 
            900                 905                 910         


Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu 
        915                 920                 925             


Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala 
    930                 935                 940                 


Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
945                 950                 955                 960 


Gln Thr Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser 
                965                 970                 975     


Ser Gly Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala 
            980                 985                 990         


Asp Leu Asp Pro Thr Glu Asn Pro  Phe Asp Leu Leu Asp  Phe Asn Gln 
        995                 1000                 1005             


Thr Gln  Pro Glu Arg Gly Asp  Asn Asn Leu Thr Arg  Asp Phe Leu 
    1010                 1015                 1020             


Ala Glu  Gly Leu Thr Pro Arg  Ile Val Gly Gly Gln  Glu Cys Lys 
    1025                 1030                 1035             


Asp Gly  Glu Cys Pro Trp Gln  Ala Leu Leu Ile Asn  Glu Glu Asn 
    1040                 1045                 1050             


Glu Gly  Phe Cys Gly Gly Thr  Ile Leu Ser Glu Phe  Tyr Ile Leu 
    1055                 1060                 1065             


Thr Ala  Ala His Cys Leu Tyr  Gln Ala Lys Arg Phe  Lys Val Arg 
    1070                 1075                 1080             


Val Gly  Asp Arg Asn Thr Glu  Gln Glu Glu Gly Gly  Glu Ala Val 
    1085                 1090                 1095             


His Glu  Val Glu Val Val Ile  Lys His Asn Arg Phe  Thr Lys Glu 
    1100                 1105                 1110             


Thr Tyr  Asp Phe Asp Ile Ala  Val Leu Arg Leu Lys  Thr Pro Ile 
    1115                 1120                 1125             


Thr Phe  Arg Met Asn Val Ala  Pro Ala Cys Leu Pro  Glu Arg Asp 
    1130                 1135                 1140             


Trp Ala  Glu Ser Thr Leu Met  Thr Gln Lys Thr Gly  Ile Val Ser 
    1145                 1150                 1155             


Gly Phe  Gly Arg Thr His Glu  Lys Gly Arg Gln Ser  Thr Arg Leu 
    1160                 1165                 1170             


Lys Met  Leu Glu Val Pro Tyr  Val Asp Arg Asn Ser  Cys Lys Leu 
    1175                 1180                 1185             


Ser Ser  Ser Phe Ile Ile Thr  Gln Asn Met Phe Cys  Ala Gly Tyr 
    1190                 1195                 1200             


Asp Thr  Lys Gln Glu Asp Ala  Cys Gln Gly Asp Ser  Gly Gly Pro 
    1205                 1210                 1215             


His Val  Thr Arg Phe Lys Asp  Thr Tyr Phe Val Thr  Gly Ile Val 
    1220                 1225                 1230             


Ser Trp  Gly Glu Gly Cys Ala  Arg Lys Gly Lys Tyr  Gly Ile Tyr 
    1235                 1240                 1245             


Thr Lys  Val Thr Ala Phe Leu  Lys Trp Ile Asp Arg  Ser Met Lys 
    1250                 1255                 1260             


Thr Arg  Gly Leu Pro Lys Ala  Lys Ser His Ala Pro  Glu Val Ile 
    1265                 1270                 1275             


Thr Ser  Ser Pro Leu Lys Asp  Lys Thr His Thr Cys  Pro Pro Cys 
    1280                 1285                 1290             


Pro Ala  Pro Glu Leu Leu Gly  Gly Pro Ser Val Phe  Leu Phe Pro 
    1295                 1300                 1305             


Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser Arg Thr  Pro Glu Val 
    1310                 1315                 1320             


Thr Cys  Val Val Val Asp Val  Ser His Glu Asp Pro  Glu Val Lys 
    1325                 1330                 1335             


Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val His Asn  Ala Lys Thr 
    1340                 1345                 1350             


Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr Tyr Arg  Val Val Ser 
    1355                 1360                 1365             


Val Leu  Thr Val Leu His Gln  Asp Trp Leu Asn Gly  Lys Glu Tyr 
    1370                 1375                 1380             


Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro Ala Pro  Ile Glu Lys 
    1385                 1390                 1395             


Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg Glu Pro  Gln Val Tyr 
    1400                 1405                 1410             


Thr Leu  Pro Pro Ser Arg Asp  Glu Leu Thr Lys Asn  Gln Val Ser 
    1415                 1420                 1425             


Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val 
    1430                 1435                 1440             


Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr 
    1445                 1450                 1455             


Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys 
    1460                 1465                 1470             


Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser 
    1475                 1480                 1485             


Cys Ser  Val Met His Glu Ala  Leu His Asn His Tyr  Thr Gln Lys 
    1490                 1495                 1500             


Ser Leu  Ser Leu Ser Pro 
    1505                 


<210>  84
<211>  1469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine SEQ ID NO :23, fusionne  SEQ ID NO: 36, fusionne  un 
       linker (GSSG)8 fusionne  SEQ ID NO: 17 fusionne SEQ ID NO:36

<400>  84

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Ala 
            20                  25                  30          


Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr Arg Asp Met Pro Trp 
        35                  40                  45              


Lys Pro Gly Pro His Arg Val Phe Val Thr Gln Glu Glu Ala His Gly 
    50                  55                  60                  


Val Leu His Arg Arg Arg Arg Ala Asn Ser Phe Leu Glu Glu Met Lys 
65                  70                  75                  80  


Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu 
                85                  90                  95      


Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp 
            100                 105                 110         


Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
        115                 120                 125             


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
    130                 135                 140                 


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
145                 150                 155                 160 


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
                165                 170                 175     


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
            180                 185                 190         


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
        195                 200                 205             


Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu 
    210                 215                 220                 


Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp 
225                 230                 235                 240 


Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro 
                245                 250                 255     


Glu Arg Gly Asp Asn Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu 
            260                 265                 270         


Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
        275                 280                 285             


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
    290                 295                 300                 


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
305                 310                 315                 320 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
                325                 330                 335     


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
            340                 345                 350         


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
        355                 360                 365             


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
    370                 375                 380                 


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
385                 390                 395                 400 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
                405                 410                 415     


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
            420                 425                 430         


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
        435                 440                 445             


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
    450                 455                 460                 


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
465                 470                 475                 480 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
                485                 490                 495     


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
            500                 505                 510         


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
        515                 520                 525             


Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    530                 535                 540                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
545                 550                 555                 560 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                565                 570                 575     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            580                 585                 590         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        595                 600                 605             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    610                 615                 620                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
625                 630                 635                 640 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                645                 650                 655     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            660                 665                 670         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        675                 680                 685             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    690                 695                 700                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
705                 710                 715                 720 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                725                 730                 735     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            740                 745                 750         


Ser Pro Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        755                 760                 765             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    770                 775                 780                 


Ser Gly Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu 
785                 790                 795                 800 


Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val 
                805                 810                 815     


Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp 
            820                 825                 830         


Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys 
        835                 840                 845             


Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly 
    850                 855                 860                 


Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly 
865                 870                 875                 880 


Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser 
                885                 890                 895     


Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro 
            900                 905                 910         


Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg 
        915                 920                 925             


Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
    930                 935                 940                 


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
945                 950                 955                 960 


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
                965                 970                 975     


Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly Leu Thr Pro Arg Ile Val 
            980                 985                 990         


Gly Gly Gln Glu Cys Lys Asp Gly  Glu Cys Pro Trp Gln  Ala Leu Leu 
        995                 1000                 1005             


Ile Asn  Glu Glu Asn Glu Gly  Phe Cys Gly Gly Thr  Ile Leu Ser 
    1010                 1015                 1020             


Glu Phe  Tyr Ile Leu Thr Ala  Ala His Cys Leu Tyr  Gln Ala Lys 
    1025                 1030                 1035             


Arg Phe  Lys Val Arg Val Gly  Asp Arg Asn Thr Glu  Gln Glu Glu 
    1040                 1045                 1050             


Gly Gly  Glu Ala Val His Glu  Val Glu Val Val Ile  Lys His Asn 
    1055                 1060                 1065             


Arg Phe  Thr Lys Glu Thr Tyr  Asp Phe Asp Ile Ala  Val Leu Arg 
    1070                 1075                 1080             


Leu Lys  Thr Pro Ile Thr Phe  Arg Met Asn Val Ala  Pro Ala Cys 
    1085                 1090                 1095             


Leu Pro  Glu Arg Asp Trp Ala  Glu Ser Thr Leu Met  Thr Gln Lys 
    1100                 1105                 1110             


Thr Gly  Ile Val Ser Gly Phe  Gly Arg Thr His Glu  Lys Gly Arg 
    1115                 1120                 1125             


Gln Ser  Thr Arg Leu Lys Met  Leu Glu Val Pro Tyr  Val Asp Arg 
    1130                 1135                 1140             


Asn Ser  Cys Lys Leu Ser Ser  Ser Phe Ile Ile Thr  Gln Asn Met 
    1145                 1150                 1155             


Phe Cys  Ala Gly Tyr Asp Thr  Lys Gln Glu Asp Ala  Cys Gln Gly 
    1160                 1165                 1170             


Asp Ser  Gly Gly Pro His Val  Thr Arg Phe Lys Asp  Thr Tyr Phe 
    1175                 1180                 1185             


Val Thr  Gly Ile Val Ser Trp  Gly Glu Gly Cys Ala  Arg Lys Gly 
    1190                 1195                 1200             


Lys Tyr  Gly Ile Tyr Thr Lys  Val Thr Ala Phe Leu  Lys Trp Ile 
    1205                 1210                 1215             


Asp Arg  Ser Met Lys Thr Arg  Gly Leu Pro Lys Ala  Lys Ser His 
    1220                 1225                 1230             


Ala Pro  Glu Val Ile Thr Ser  Ser Pro Leu Lys Asp  Lys Thr His 
    1235                 1240                 1245             


Thr Cys  Pro Pro Cys Pro Ala  Pro Glu Leu Leu Gly  Gly Pro Ser 
    1250                 1255                 1260             


Val Phe  Leu Phe Pro Pro Lys  Pro Lys Asp Thr Leu  Met Ile Ser 
    1265                 1270                 1275             


Arg Thr  Pro Glu Val Thr Cys  Val Val Val Asp Val  Ser His Glu 
    1280                 1285                 1290             


Asp Pro  Glu Val Lys Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 
    1295                 1300                 1305             


His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr 
    1310                 1315                 1320             


Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 
    1325                 1330                 1335             


Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro 
    1340                 1345                 1350             


Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 
    1355                 1360                 1365             


Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Arg Asp  Glu Leu Thr 
    1370                 1375                 1380             


Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 
    1385                 1390                 1395             


Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 
    1400                 1405                 1410             


Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 
    1415                 1420                 1425             


Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln 
    1430                 1435                 1440             


Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 
    1445                 1450                 1455             


His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Pro 
    1460                 1465                 


<210>  85
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant de SEQ ID NO :1 comprenant la substitution des acides 
       amines 43 a 52 par la sequence DFLAEGLTPR

<400>  85

Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
1               5                   10                  15      


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
            20                  25                  30          


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Asp Phe Leu Ala Glu Gly 
        35                  40                  45              


Leu Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys 
    50                  55                  60                  


Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly 
65                  70                  75                  80  


Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu 
                85                  90                  95      


Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu 
            100                 105                 110         


Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys 
        115                 120                 125             


His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu 
    130                 135                 140                 


Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys 
145                 150                 155                 160 


Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr 
                165                 170                 175     


Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser 
            180                 185                 190         


Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys 
        195                 200                 205             


Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly 
    210                 215                 220                 


Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
225                 230                 235                 240 


His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser 
                245                 250                 255     


Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
            260                 265                 270         


Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly 
        275                 280                 285             


Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro 
    290                 295                 300                 


Leu Lys 
305     


<210>  86
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant de SEQ ID NO :1 comprenant l'insertion de DFLAEGLTPR entre
       les acides amines 52 et 53 et la deletion des acides amines 4 a 13

<400>  86

Ser Val Ala Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
1               5                   10                  15      


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
            20                  25                  30          


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Asp Phe Leu Ala Glu Gly 
        35                  40                  45              


Leu Thr Pro Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys 
    50                  55                  60                  


Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly 
65                  70                  75                  80  


Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu 
                85                  90                  95      


Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu 
            100                 105                 110         


Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys 
        115                 120                 125             


His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu 
    130                 135                 140                 


Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys 
145                 150                 155                 160 


Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr 
                165                 170                 175     


Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser 
            180                 185                 190         


Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys 
        195                 200                 205             


Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly 
    210                 215                 220                 


Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
225                 230                 235                 240 


His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser 
                245                 250                 255     


Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
            260                 265                 270         


Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly 
        275                 280                 285             


Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro 
    290                 295                 300                 


Leu Lys 
305     


<210>  87
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer 5furine-1

<400>  87
tcttccattt cagctagcgc cgccaccatg gaactgagac                             40


<210>  88
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer 3furine-1

<400>  88
gatcctcggc gcgccctatc agtggtggtg gtggtggtgc                             40


<210>  89
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer Furine1

<400>  89
gaagcctgct ctagttctct ggctacc                                           27


<210>  90
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer furine2

<400>  90
ggtagccaga gaactagagc aggcttc                                           27


<210>  91
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer furine3

<400>  91
gaagtgcatc attcatatcc tgaccgag                                          28


<210>  92
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - Furine4

<400>  92
ctcggtcagg atatgaatga tgcacttc                                          28


<210>  93
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - Furine5

<400>  93
gcaagacact gacaagttca caggcc                                            26


<210>  94
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - elf4g-1

<400>  94
attcgagatc caaaccaagg ag                                                22


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer - HGH4

<400>  95
aacttccagg gccaggagag                                                   20


<210>  96
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - 5EF1a

<400>  96
gtggagactg aagttaggcc ag                                                22


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer - 2BghpA

<400>  97
cagatggctg gcaactagaa                                                   20


<210>  98
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - GA1

<400>  98
gcccctgata gcatcacatg gaag    
                                          24


<210>  99
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - furine6

<400>  99
ggcctgtgaa cttgtcagtg tcttgc      


