                         SEQUENCE LISTING

<110>  Technical University of Denmark
 
<120>  New Therapeutics for Treatment of Autoimmune Diseases

<130>  P2395PC00

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  Specific DNA-antigen targeted by anti-DNA antibodies in SLE 
       disease

<400>  1
tcctttcttt ctttctt                                                      17


<210>  2
<211>  28
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<223>  Specific DNA-antigen targeted by anti-DNA antibodies in SLE 
       disease

<220>
<221>  misc_feature
<222>  (1)..(28)
<223>  Specific DNA-antigen targeted by anti-DNA antibodies in SLE 
       disease

<400>  2
ttagggttag ggttagggtt agggttag                                          28


<210>  3
<211>  19
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Specific peptide antigen mimicking histone H3 peptides to bind to
       antinuclear antibodies

<400>  3

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


Gly Gly Cys 
            


<210>  4
<211>  18
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  P41, liver targeting peptide

<400>  4

Ser Trp Leu Arg Arg Ile Trp Arg Trp Ile Cys Lys Val Leu Ser Arg 
1               5                   10                  15      


Phe Lys 
        


<210>  5
<211>  8
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Specific peptide antigen mimicking histone H3 peptides (partial) 
       to bind to antinuclear antibodies. The peptide is acetylated at 
       the N-terminal.

<400>  5

Ala Arg Thr Lys Gln Thr Ala Arg 
1               5               


<210>  6
<211>  14
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  Specific peptide antigen mimicking histone H3 peptides (partial) 
       to bind to antinuclear antibodies. The peptide is acetylated at 
       the N-terminal.

<400>  6

Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro Gly 
1               5                   10                  


<210>  7
<211>  24
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  Antigen

<400>  7
atcgatcgat cgatcgatcg atcg                                              24


<210>  8
<211>  24
<212>  DNA
<213>  synthetic


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  antigen

<400>  8
tccttccttc cttccttcct tcct                                              24


<210>  9
<211>  21
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  potential pepide epitope

<400>  9

His His Pro Gly Ile Ala Glu Phe Pro Ser Cit Gly Lys Ser Ser Ser 
1               5                   10                  15      


Tyr Ser Lys Gln Phe 
            20      


<210>  10
<211>  21
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  potential peptide epitope

<400>  10

His His Pro Gly Ile Ala Glu Phe Pro Ser Cit Gly Lys Ser Tyr Ser 
1               5                   10                  15      


Tyr Ser Lys Gln Phe 
            20      


<210>  11
<211>  21
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  potential peptide epitope

<400>  11

His Gly Pro Gly Ile Ala Glu Phe Pro Ser Cit Gly Pro Ser Tyr Ser 
1               5                   10                  15      


Tyr Ser Lys Gln Phe 
            20      


<210>  12
<211>  21
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  potential peptide epitope

<400>  12

His Gly Ile Gly Leu Ala Glu Phe Pro Ser Cit Gly Lys Ile Ser Ala 
1               5                   10                  15      


Tyr Ser Lys Gln Phe 
            20      


<210>  13
<211>  21
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  potential peptide epitope

<400>  13

His Gly Pro Gly Gly Ala Glu Phe Pro Ser Cit Gly Lys Ala Tyr Ser 
1               5                   10                  15      


Tyr Gly Lys Gln Phe 
            20      


<210>  14
<211>  13
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  potential peptide epitope

<400>  14

Ala Glu Gly Gly Gly Val Cit Gly Pro Arg Val Val Glu 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  potential peptide epitope

<400>  15

Ala Ser Ser Gly Gly Val Cit Gly Pro Arg Ile Val Glu 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  potential peptide epitope

<400>  16

Ala Glu Gly Ala Ser Val Cit Gly Pro Arg Val Val Glu 
1               5                   10              


<210>  17
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  17

Lys Asp Leu Leu Pro Ser Cit Asp Cit Gln His Leu Pro Leu Ile Lys 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  18

Lys Asp Leu Leu Pro Ser Cit Asp Gly Gln His Leu Pro Leu Ile Lys 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  19

Lys Asp Leu Leu Pro Ser Cit Asp Cit Gly Ala Ile Pro Leu Ile Lys 
1               5                   10                  15      


<210>  20
<211>  23
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(23)
<223>  potential peptide epitope

<400>  20

Gln Met Arg Met Glu Leu Glu Cit Pro Gly Gly Asn Glu Ile Thr Cit 
1               5                   10                  15      


Gly Gly Ser Thr Ser Tyr Gly 
            20              


<210>  21
<211>  14
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  potential peptide epitope

<400>  21

Asn Val Ser Pro Gly Thr Cit Cit Glu Tyr His Thr Glu Lys 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  potential peptide epitope

<400>  22

Asn Val Ala Tyr Pro Thr Cit Cit Glu Tyr His Gly Glu Lys 
1               5                   10                  


<210>  23
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  23

Ser Thr Cit Ser Val Ser Ser Ser Ser Tyr Cit Cit Met Phe Gly Gly 
1               5                   10                  15      


<210>  24
<211>  15
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  potential peptide epitope

<400>  24

Ala Ala Pro Val Ser Gly Ser Ser Tyr Cit Cit Met Phe Gly Gly 
1               5                   10                  15  


<210>  25
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  25

Ser Thr Cit Ser Val Ser Ser Ser Ser Tyr Lys Gly Ala Phe Leu Gly 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  26

Val Tyr Ala Thr Cit Ser Ser Ala Val Cit Leu Cit Ser Ser Val Pro 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  27

Val Tyr Ala Thr Tyr Gly Ser Ala Val Cit Leu Cit Ser Ser Val Pro 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  28

Val Tyr Ala Thr Cit Ser Ser Ala Val Gly Leu Gly Ser Ser Val Pro 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  29

Ala Cit Thr Lys Gln Thr Ala Cit Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  30

Ala Ala Cit Lys Ser Ala Pro Ser Thr Gly Gly Val Lys Lys Pro His 
1               5                   10                  15      


<210>  31
<211>  17
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  potential peptide epitope

<400>  31

Tyr Cit Pro Gly Thr Val Ala Leu Cit Glu Ile Lys Lys Tyr Gln Lys 
1               5                   10                  15      


Ser 
    


<210>  32
<211>  19
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  potential peptide epitope

<400>  32

Leu Ile Cit Lys Leu Pro Phe Gln Cit Leu Val Cit Glu Ile Ala Gln 
1               5                   10                  15      


Asp Phe Lys 
            


<210>  33
<211>  16
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  potential peptide epitope

<400>  33

Leu Cys Ala Ile His Ala Lys Cit Val Thr Ile Met Pro Lys Asp Ile 
1               5                   10                  15      


