﻿               SEQUENCE LISTING

<110> SANOFI

<120> MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE

<130> PR82769/DC1/MGG

<150> EP18305093
<151> 2018-01-31

<160> 198

<170> BiSSAP 1.3.6

<210> 1
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -palmitoyl group (-Palm)

<400> 1
Leu Glu Gly Arg Glu Lys Val Arg Ala Ala Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 2
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 2
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 3
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-stearoyl group (-gE-Stea)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 3
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 4
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 14
<223> Xaa in position 14 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 17
<223> Xaa in position 17 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-palmitoyl group (-(gE)2-Palm)

<400> 4
Glu Leu Glu Gly Arg Glu Lys Val Arg Ala Ala Ile Xaa Xaa Glu Gly 
1               5                   10                  15      
Xaa Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  25  

<210> 5
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-palmitoyl group (-(gE)2-Palm)

<220> 
<221> VARIANT
<222> 23
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 5
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Met 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Xaa 
            20              

<210> 6
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 14
<223> Xaa in position 14 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 17
<223> Xaa in position 17 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 6
Glu Leu Glu Gly Arg Glu Lys Val Arg Ala Ala Ile Xaa Xaa Glu Gly 
1               5                   10                  15      
Xaa Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25      

<210> 7
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 7
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Met 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 8
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 8
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 9
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 9
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 10
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG2-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl (-(gE)3-Palm)

<400> 10
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 11
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG2-PEG2-

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 11
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 12
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG2-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -PEG2-(gamma glutamic
      acid)3-Palmitoyl group (-PEG2-(gE)3-Palm)

<400> 12
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 13
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG2-

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)2-(gE)3-Palm)

<400> 13
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 14
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 14
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 15
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-stearoyl group (-(gE)4-Stea)

<400> 15
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa Xaa 
            20                  25      

<210> 16
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-stearoyl group (-(gE)4-Stea)

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 16
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 17
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 17
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 18
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2DGA-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 18
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 19
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2DGA-PEG2DGA-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 19
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 20
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2DGA-PEG2DGA-PEG2DGA-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 20
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 21
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -stearoyl group (-stea)

<400> 21
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 22
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-stearoyl group (-gE-Stea)

<400> 22
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa Xaa 
            20                  25      

<210> 23
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 23
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Met 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 24
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents PEG12

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 24
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 25
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 25
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Met 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 26
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl (-(gE)3-Palm)

<400> 26
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 27
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 27
Leu Glu Gly Arg Glu Lys Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 28
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 28
Leu Glu Gly Arg Glu Lys Val Arg Xaa Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 29
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 29
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 30
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 30
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 31
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 31
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa Xaa 
            20                  25      

<210> 32
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 32
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa Xaa 
            20                  25      

<210> 33
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 33
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 34
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 34
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 35
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 35
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Met 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 36
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 36
Leu Glu Gly Arg Glu Lys Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 37
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 37
Leu Glu Gly Arg Glu Lys Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 38
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 38
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 39
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents α-Methyl-serine (Mse)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-stearoyl group (-(gE)4-Stea)

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 39
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Xaa Lys Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 40
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents α-Methyl-serine (Mse)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-stearoyl group (-(gE)4-Stea)

<400> 40
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Xaa Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 41
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents α-Methyl-serine (Mse)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 41
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Xaa Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 42
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-stearoyl group (-(gE)4-Stea)

<400> 42
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 43
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 43
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 44
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)3-(gE)3-Palm)

<400> 44
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Tyr Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 45
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG12-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl (-(gE)3-Stea)

<400> 45
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 46
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG12-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 46
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Tyr Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 47
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents -PEG24-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 47
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Met 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 48
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG28-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 48
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa Xaa 
            20                  25      

<210> 49
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG28-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 49
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 50
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -PEG2-Palmitoyl group
      (-PEG2-Palm)

<400> 50
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 51
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-Stearoyl group
      (-(PEG2)2-Stea)

<400> 51
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 52
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-Stearoyl group
      (-(PEG2)3-Stea)

<400> 52
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 53
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -PEG2-(gamma glutamic
      acid)-Palmitoyl group (-PEG2-gE-Palm)

<400> 53
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 54
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 14
<223> Xaa in position 14 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 17
<223> Xaa in position 17 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -PEG2-(gamma glutamic
      acid)2-Palmitoyl group (-PEG2-(gE)2-Palm)

<400> 54
Glu Leu Glu Gly Arg Glu Lys Val Arg Ala Ala Ile Xaa Xaa Glu Gly 
1               5                   10                  15      
Xaa Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  25  

<210> 55
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -PEG2-(gamma glutamic
      acid)3-Palmitoyl group (-PEG2-(gE)3-Palm)

<400> 55
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 56
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)-Stearoyl group (-(PEG2)2-gE-Stea)

<400> 56
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 57
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 14
<223> Xaa in position 14 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 17
<223> Xaa in position 17 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)2-Palmitoyl group (-(PEG2)2-(gE)2-Palm)

<400> 57
Glu Leu Glu Gly Arg Glu Lys Val Arg Ala Ala Ile Xaa Xaa Glu Gly 
1               5                   10                  15      
Xaa Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  25  

<210> 58
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)2-(gE)3-Palm)

<400> 58
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 59
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)2-(gE)3-Palm)

<400> 59
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 60
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)2-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 60
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 61
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)2-(gE)3-Palm)

<400> 61
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 62
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)2-(gE)3-Palm)

<400> 62
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 63
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)3-(gE)3-Palm)

<400> 63
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 64
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)4-(gE)3-Palm)

<400> 64
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 65
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)3-(gE)4-Palm)

<400> 65
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 66
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -PEG12-(gamma glutamic
      acid)3-Palmitoyl group (-PEG12-(gE)3-Palm)

<400> 66
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 67
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)2-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 67
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 68
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)2-(gE)3-Stea)

<400> 68
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Glu 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 69
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)2-(gE)3-Stea)

<400> 69
Leu Glu Gly Arg Glu Lys Val Arg Xaa Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 70
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)2-(gE)3-Stea)

<400> 70
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 71
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)2-(gE)3-Stea)

<400> 71
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 72
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)2-(gE)3-Stea)

<400> 72
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Xaa Lys Xaa 
            20                  25  

<210> 73
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)2-(gE)3-Stea)

<400> 73
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 74
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 74
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 75
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 75
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 76
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 76
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Thr Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 77
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 77
Leu Glu Gly Arg Glu Lys Val Arg Leu Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Thr Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 78
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 78
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Tyr Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 79
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 79
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa 
            20                  

<210> 80
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 80
Leu Glu Gly Arg Glu Lys Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa 
            20                  

<210> 81
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 81
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 82
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)4-Stearoyl group (-(PEG2)3-(gE)4-Stea)

<400> 82
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 83
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 83
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 84
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 84
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 85
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 85
Leu Glu Gly Arg Glu Lys Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 86
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 86
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Leu Xaa 
            20                  25  

<210> 87
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 87
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Xaa Leu Xaa 
            20                  25  

<210> 88
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)4-Stearoyl group (-(PEG2)3-(gE)4-Stea)

<400> 88
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 89
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)4-Stearoyl group (-(PEG2)3-(gE)4-Stea)

<400> 89
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 90
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)4-(gE)3-Stea)

<400> 90
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 91
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)4-(gE)3-Stea)

<400> 91
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 92
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)4-(gE)3-Stea)

<400> 92
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 93
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)5-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)5-(gE)3-Stea)

<400> 93
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 94
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)-(gamma
      glutamic acid)3-Stearoyl group (-(PEG2DGA)-(gE)3-Stea)

<400> 94
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 95
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)2-(gamma
      glutamic acid)3-Stearoyl group (-(PEG2DGA)2-(gE)3-Stea)

<400> 95
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 96
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)3-(gamma
      glutamic acid)3-Stearoyl group (-(PEG2DGA)3-(gE)3-Stea)

<400> 96
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 97
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -PEG12-(gamma glutamic
      acid)3-Stearoyl group (-(PEG12)-(gE)3-Stea)

<400> 97
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 98
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-PEG2-Stearoyl group (-(PEG2)2-(gE)3-PEG2-Stea)

<400> 98
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 99
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)2-PEG2-(gamma glutamic acid)-Stearoyl group
      (-(PEG2)2-(gE)2-PEG2-(gE)-Stea)

<400> 99
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 100
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)2-PEG2-(gamma glutamic acid)-Stearoyl group
      (-(PEG2)2-(gE)2-PEG2-(gE)-Stea)

<400> 100
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 101
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)2-PEG2-(gamma glutamic acid)-Stearoyl
      (-(PEG2)2-(gE)2-PEG2-(gE)-Stea)

<400> 101
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 102
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-PEG2-(gamma glutamic acid)-Stearoyl group
      (-(PEG2)2-(gE)3-PEG2-(gE)-Stea)

<400> 102
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 103
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 1-Naphtylalanine (1-Nal)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)3-PEG2-(gamma glutamic acid)-Stearoyl group
      (-(PEG2)2-(gE)3-PEG2-(gE)-Stea)

<400> 103
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 104
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-(PEG2)2-(gamma glutamic acid)-Stearoyl group
      (-(gE)2-(PEG2)2-(gE)-Stea)

<400> 104
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 105
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-(PEG2)2-(gamma glutamic acid)-Stearoyl group
      (-(gE)2-(PEG2)2-(gE)-Stea)

<400> 105
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 106
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-(PEG2)3-(gamma glutamic acid)-Stearoyl group
      (-(gE)2-(PEG2)3-(gE)-Stea)

<400> 106
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 107
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 28
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 28
<223> Xaa in position 28 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 107
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Lys Xaa Xaa Xaa 
            20                  25              

<210> 108
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 28
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 28
<223> Xaa in position 28 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 108
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Lys Xaa Xaa Xaa 
            20                  25              

<210> 109
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 28
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 28
<223> Xaa in position 28 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 109
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Lys Xaa Xaa Xaa 
            20                  25              

<210> 110
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 110
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa Xaa Xaa 
            20                  25          

<210> 111
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)5-Stearoyl group (-(PEG2)3-(gE)5-Stea)

<400> 111
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 112
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 112
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 113
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 113
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 114
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 114
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 115
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)4-Stearoyl group (-(PEG2)3-(gE)4-Stea)

<400> 115
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 116
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 116
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 117
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 117
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 118
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 118
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 119
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 119
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 120
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Lauroyl group (-(PEG2)3-(gE)3-Lau)

<400> 120
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 121
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 121
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 122
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -PEG4-PEG4-

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)5-stearoyl group (-(gE)5-Stea)

<400> 122
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Lys Xaa Xaa 
            20                  25          

<210> 123
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG4-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 123
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 124
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG4-PEG4-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-stearoyl group (-(gE)3-Stea)

<400> 124
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 125
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents α-Methyl-tryptophane (Mtr)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 125
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 126
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Citruline (Cit)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 126
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Ala Xaa Xaa 
            20                  25  

<210> 127
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 127
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Leu Xaa 
            20                  25  

<210> 128
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)4-Stearoyl group (-(PEG2)3-(gE)4-Stea)

<400> 128
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 129
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Citruline (Cit)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 129
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Lys Xaa Xaa 
            20                  25  

<210> 130
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)4-(gE)4-Palm)

<400> 130
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 131
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 131
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 132
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Citruline (Cit)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)4-(gE)3-Stea)

<400> 132
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Ala Xaa Xaa 
            20                  25  

<210> 133
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Nω-methyl-arginine (Rme)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 133
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Lys Xaa Xaa 
            20                  25  

<210> 134
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents Nε,Nε,Nε-trimethyl-lysine (Tml)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 134
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Xaa Xaa Xaa 
            20                  25  

<210> 135
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)4-(gE)3-Stea)

<400> 135
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa Xaa 
            20                  25  

<210> 136
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 136
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 137
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Nω-methyl-arginine (Rme)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents Nε,Nε,Nε-trimethyl-lysine (Tml)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 137
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Xaa Xaa Xaa 
            20                  25  

<210> 138
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Nω-methyl-arginine (Rme)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents Nε,Nε,Nε-trimethyl-lysine (Tml)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl (-(PEG2)3-(gE)3-Stea)

<400> 138
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Xaa Xaa Xaa 
            20                  25  

<210> 139
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 139
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Ala Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 140
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)4-(gE)4-Palm)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 140
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 141
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Nω-methyl-arginine (Rme)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents Nε,Nε,Nε-trimethyl-lysine (Tml)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)4-(gE)4-Palm)

<400> 141
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Xaa Xaa Xaa 
            20                  25  

<210> 142
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 142
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 143
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 143
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 144
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 144
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 145
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 145
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 146
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 146
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 147
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)4-(gE)4-Palm)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 147
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 148
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Nω, Nω'-dimethyl-arginine
      (symmetrical) (Rds)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 148
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Xaa Lys Xaa Xaa 
            20                  25  

<210> 149
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 149
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 150
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 150
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 151
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 22
<223> Xaa in position 22 represents Nω-methyl-arginine (Rme)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 151
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Xaa Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 152
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents α-Methyl-phenylalanine (Mph)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 152
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 153
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)4-(gE)3-Palm)

<400> 153
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 154
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)4-(gE)4-Palm)

<400> 154
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa 
            20                  25  

<210> 155
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 155
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Ala Ala Xaa Xaa 
            20                  25  

<210> 156
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a-(PEG2DGA)2-(gamma
      glutamic acid)3-Stearoyl group (-(PEG2DGA)2-(gE)3-Stea)

<400> 156
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Ala Ala Xaa Xaa 
            20                  25  

<210> 157
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 157
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 158
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 5-Hydroxy-tryptophane (Wox)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 158
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 159
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-palmitoyl group (-(gE)2-Palm)

<400> 159
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa Xaa Xaa Xaa 
            20                  25          

<210> 160
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-palmitoyl group (-(gE)2-Palm)

<400> 160
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 161
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-Lauroyl group (-(gE)4-Lau)

<400> 161
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 162
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 162
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 163
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Pentadecanoyl group (-(PEG2)3-(gE)3-Penta)

<400> 163
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 164
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Heptadecanoyl group (-(PEG2)3-(gE)3-Hepta)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 164
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 165
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)2-(gamma glutamic
      acid)2-PEG2-(gamma glutamic acid)-Palmitoyl group
      (-(PEG2)2-(gE)2-PEG2-(gE)-Palm)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 165
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 166
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)2-(gE)3-Palm)

<400> 166
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 167
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-Pentadecanoyl group (-(gE)4-Penta)

<400> 167
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 168
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-Pentadecanoyl group (-(gE)2-Penta)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 168
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 169
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-palmitoyl group (-(gE)2-Palm)

<400> 169
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 170
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-plamitoyl group (-(gE)4-Palm)

<400> 170
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 171
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Eicosanoyl group ((-PEG2)3-(gE)3-Eico)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 171
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 172
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-Myristoyl group (-(gE)4-Myr)

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 172
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 173
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3- docosanoyl group ((-PEG2)3-(gE)3-Doco)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 173
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 174
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)3-(gE)3-Stea)

<400> 174
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Lys Xaa 
            20                  25  

<210> 175
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2DGA-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 175
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 176
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2DGA-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 176
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 177
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2DGA-PEG2DGA-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 177
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 178
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Myristoyl group (-(PEG2)3-(gE)3-Myr)

<400> 178
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 179
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 179
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Tyr Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 180
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)4-Stearoyl group (-(PEG2)4-(gE)4-Stea)

<400> 180
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa 
            20                  25  

<210> 181
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG8-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 181
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa Xaa Xaa 
            20                  25      

<210> 182
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-Pentadecanoyl group (-(gE)4-Penta)

<400> 182
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 183
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<400> 183
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa 
            20                  25  

<210> 184
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-Pentadecanoyl group (-(gE)2-Penta)

<400> 184
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 185
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-palmitoyl group (-(gE)2-Palm)

<400> 185
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 186
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)2- (-(gE)2-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)2-Pentadecanoyl group (-(gE)2-Penta)

<400> 186
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 187
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a ), -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 187
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 188
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-Pentadecanoyl group (-(gE)3-Penta)

<400> 188
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 189
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Pentadecanoyl group (-(TTDS)3-(gE)3-Penta)

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 189
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa 
            20                  25  

<210> 190
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)4-Myristoyl group (-(gE)4-Myr)

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 190
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 191
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)4-(gE)4-Palm)

<400> 191
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Gln 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa 
            20                  25  

<210> 192
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -PEG2-PEG2-PEG2-PEG2-

<220> 
<221> VARIANT
<222> 26
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(gamma glutamic
      acid)3-palmitoyl group (-(gE)3-Palm)

<400> 192
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa 
            20                  25      

<210> 193
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents 2-amino hexanoic acid (Norleucine -
      Nle)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 25
<223> Xaa in position 25 represents -TTDS-TTDS-TTDS-

<220> 
<221> VARIANT
<222> 26
<223> Xaa in position 26 represents -(gamma glutamic acid)3- (-(gE)3-)

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 27
<223> Xaa in position 27 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -gamma glutamic
      acid-palmitoyl group (-gE-Palm)

<400> 193
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa Xaa Xaa Xaa 
            20                  25          

<210> 194
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> H2-relaxin chain A

<220> 
<223> H2-relaxin chain A

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with a hydrogen atom (H) on its
      N-terminal extremity

<400> 194
Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      
Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  

<210> 195
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> H2-relaxin chain B

<220> 
<223> H2-relaxin chain B

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with a hydrogen atom (H) on its
      N-terminal extremity

<400> 195
Asp Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      
Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
            20                  25                  

<210> 196
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin 2 – comparison example

<220> 
<223> Peptide analogue of the B-chain of Relaxin 2 – comparison example

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with a hydrogen atom (H) on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 196
Val Ile Lys Leu Ser Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile 
1               5                   10                  15      
Ser Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25          

<210> 197
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin 2 – comparison example

<220> 
<223> Peptide analogue of the B-chain of Relaxin 2 – comparison example

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 197
Val Ile Lys Leu Ser Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile 
1               5                   10                  15      
Ser Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25          

<210> 198
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin 2 – comparison example

<220> 
<223> Peptide analogue of the B-chain of Relaxin 2 – comparison example

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 198
Val Ile Lys Leu Ser Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile 
1               5                   10                  15      
Ser Gly Met Ser Thr Trp Ser Lys Lys Lys Lys 
            20                  25          

