                         SEQUENCE LISTING

<110>  University of Pittsburgh
       Delgoffe, Greg
 
<120>  EXPRESSION OF METABOLIC MODULATORS IN TUMOR MICROENVIRONMENT TO 
       IMPROVE TUMOR THERAPY

<130>  8123-100245-02

<150>  US 62/622,547
<151>  2018-01-26

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  3444
<212>  DNA
<213>  Homo sapiens

<400>  1
gtaggaatcg cagcgccagc ggttgcaagg cccaagaagc ccatcctggg aaggaaaatg       60

cattggggaa ccctgtgcgg attcttgtgg ctttggccct atcttttcta tgtccaagct      120

gtgcccatcc aaaaagtcca agatgacacc aaaaccctca tcaagacaat tgtcaccagg      180

atcaatgaca tttcacacac gcagtcagtc tcctccaaac agaaagtcac cggtttggac      240

ttcattcctg ggctccaccc catcctgacc ttatccaaga tggaccagac actggcagtc      300

taccaacaga tcctcaccag tatgccttcc agaaacgtga tccaaatatc caacgacctg      360

gagaacctcc gggatcttct tcacgtgctg gccttctcta agagctgcca cttgccctgg      420

gccagtggcc tggagacctt ggacagcctg gggggtgtcc tggaagcttc aggctactcc      480

acagaggtgg tggccctgag caggctgcag gggtctctgc aggacatgct gtggcagctg      540

gacctcagcc ctgggtgctg aggccttgaa ggtcactctt cctgcaagga ctacgttaag      600

ggaaggaact ctggcttcca ggtatctcca ggattgaaga gcattgcatg gacacccctt      660

atccaggact ctgtcaattt ccctgactcc tctaagccac tcttccaaag gcataagacc      720

ctaagcctcc ttttgcttga aaccaaagat atatacacag gatcctattc tcaccaggaa      780

gggggtccac ccagcaaaga gtgggctgca tctgggattc ccaccaaggt cttcagccat      840

caacaagagt tgtcttgtcc cctcttgacc catctccccc tcactgaatg cctcaatgtg      900

accaggggtg atttcagaga gggcagaggg gtaggcagag cctttggatg accagaacaa      960

ggttccctct gagaattcca aggagttcca tgaagaccac atccacacac gcaggaactc     1020

ccagcaacac aagctggaag cacatgttta tttattctgc attttattct ggatggattt     1080

gaagcaaagc accagcttct ccaggctctt tggggtcagc cagggccagg ggtctccctg     1140

gagtgcagtt tccaatccca tagatgggtc tggctgagct gaacccattt tgagtgactc     1200

gagggttggg ttcatctgag caagagctgg caaaggtggc tctccagtta gttctctcgt     1260

aactggtttc atttctactg tgactgatgt tacatcacag tgtttgcaat ggtgttgccc     1320

tgagtggatc tccaaggacc aggttatttt aaaaagattt gttttgtcaa gtgtcatatg     1380

taggtgtctg cacccagggg tggggaatgt ttgggcagaa gggagaagga tctagaatgt     1440

gttttctgaa taacatttgt gtggtgggtt ctttggaagg agtgagatca ttttcttatc     1500

ttctgcaatt gcttaggatg tttttcatga aaatagctct ttcagggggg ttgtgaggcc     1560

tggccaggca ccccctggag agaagtttct ggccctggct gaccccaaag agcctggaga     1620

agctgatgct ttgcttcaaa tccatccaga ataaaacgca aagggctgaa agccatttgt     1680

tggggcagtg gtaagctctg gctttctccg actgctaggg agtggtcttt cctatcatgg     1740

agtgacggtc ccacactggt gactgcgatc ttcagagcag gggtccttgg tgtgaccctc     1800

tgaatggtcc agggttgatc acactctggg tttattacat ggcagtgttc ctatttgggg     1860

cttgcatgcc aaattgtagt tcttgtctga ttggctcacc caagcaaggc caaaattacc     1920

aaaaatcttg gggggttttt actccagtgg tgaagaaaac tcctttagca ggtggtcctg     1980

agacctgaca agcactgcta ggcgagtgcc aggactcccc aggccaggcc accaggatgg     2040

cccttcccac tggaggtcac attcaggaag atgaaagagg aggtttgggg tctgccacca     2100

tcctgctgct gtgtttttgc tatcacacag tgggtggtgg atctgtccaa ggaaacttga     2160

atcaaagcag ttaactttaa gactgagcac ctgcttcatg ctcagccctg actggtgcta     2220

taggctggag aagctcaccc aataaacatt aagattgagg cctgccctca gggatcttgc     2280

attcccagtg gtcaaaccgc actcacccat gtgccaaggt ggggtattta ccacagcagc     2340

tgaacagcca aatgcatggt gcagttgaca gcaggtggga aatggtatga gctgaggggg     2400

gccgtgccca ggggcccaca gggaaccctg cttgcacttt gtaacatgtt tacttttcag     2460

ggcatcttag cttctattat agccacatcc ctttgaaaca agataactga gaatttaaaa     2520

ataagaaaat acataagacc ataacagcca acaggtggca ggaccaggac tatagcccag     2580

gtcctctgat acccagagca ttacgtgagc caggtaatga gggactggaa ccagggagac     2640

cgagcgcttt ctggaaaaga ggagtttcga ggtagagttt gaaggaggtg agggatgtga     2700

attgcctgca gagagaagcc tgttttgttg gaaggtttgg tgtgtggaga tgcagaggta     2760

aaagtgtgag cagtgagtta cagcgagagg cagagaaaga agagacagga gggcaagggc     2820

catgctgaag ggaccttgaa gggtaaagaa gtttgatatt aaaggagtta agagtagcaa     2880

gttctagaga agaggctggt gctgtggcca gggtgagagc tgctctggaa aatgtgaccc     2940

agatcctcac aaccacctaa tcaggctgag gtgtcttaag ccttttgctc acaaaacctg     3000

gcacaatggc taattcccag agtgtgaaac ttcctaagta taaatggttg tctgtttttg     3060

taacttaaaa aaaaaaaaaa aagtttggcc gggtgcggtg gctcacgcct gtaatcccag     3120

cactttggga ggccaaggtg gggggatcac aaggtcacta gatggcgagc atcctggcca     3180

acatggtgaa accccgtctc tactaaaaac acaaaagtta gctgagcgtg gtggcgggcg     3240

cctgtagtcc cagccactcg ggaggctgag acaggagaat cgcttaaacc tgggaggcgg     3300

agagtacagt gagccaagat cgcgccactg cactccggcc tgatgacaga gcgagattcc     3360

gtcttaaaaa aaaaaaaaaa aaagtttgtt tttaaaaaaa tctaaataaa ataactttgc     3420

cccctgcaaa aaaaaaaaaa aaaa                                            3444


<210>  2
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  3
<211>  4969
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4045)..(4144)
<223>  n is a, c, g, t or u

<400>  3
ctcgaggggc ctagacattg ccctccagag agagcaccca acaccctcca ggcttgaccg       60

gccagggtgt ccccttccta ccttggagag agcagcccca gggcatcctg cagggggtgc      120

tgggacacca gctggccttc aaggtctctg cctccctcca gccaccccac tacacgctgc      180

tgggatcctg gatctcagct ccctggccga caacactggc aaactcctac tcatccacga      240

aggccctcct gggcatggtg gtccttccca gcctggcagt ctgttcctca cacaccttgt      300

tagtgcccag cccctgaggt tgcagctggg ggtgtctctg aagggctgtg agcccccagg      360

aagccctggg gaagtgcctg ccttgcctcc ccccggccct gccagcgcct ggctctgccc      420

tcctacctgg gctcccccca tccagcctcc ctccctacac actcctctca aggaggcacc      480

catgtcctct ccagctgccg ggcctcagag cactgtggcg tcctggggca gccaccgcat      540

gtcctgctgt ggcatggctc agggtggaaa gggcggaagg gaggggtcct gcagatagct      600

ggtgcccact accaaacccg ctcggggcag gagagccaaa ggctgggtgt gtgcagagcg      660

gccccgagag gttccgaggc tgaggccagg gtgggacata gggatgcgag gggccggggc      720

acaggatact ccaacctgcc tgcccccatg gtctcatcct cctgcttctg ggacctcctg      780

atcctgcccc tggtgctaag aggcaggtaa ggggctgcag gcagcagggc tcggagccca      840

tgccccctca ccatgggtca ggctggacct ccaggtgcct gttctgggga gctgggaggg      900

ccggaggggt gtaccccagg ggctcagccc agatgacact atgggggtga tggtgtcatg      960

ggacctggcc aggagagggg agatgggctc ccagaagagg agtgggggct gagagggtgc     1020

ctggggggcc aggacggagc tgggccagtg cacagcttcc cacacctgcc cacccccaga     1080

gtcctgccgc cacccccaga tcacacggaa gatgaggtcc gagtggcctg ctgaggactt     1140

gctgcttgtc cccaggtccc caggtcatgc cctccttctg ccaccctggg gagctgaggg     1200

cctcagctgg ggctgctgtc ctaaggcagg gtgggaacta ggcagccagc agggagggga     1260

cccctccctc actcccactc tcccaccccc accaccttgg cccatccatg gcggcatctt     1320

gggccatccg ggactgggga caggggtcct ggggacaggg gtccggggac agggtcctgg     1380

ggacaggggt gtggggacag gggtctgggg acaggggtgt ggggacaggg gtgtggggac     1440

aggggtctgg ggacaggggt gtggggacag gggtccgggg acaggggtgt ggggacaggg     1500

gtctggggac aggggtgtgg ggacaggggt gtggggacag gggtctgggg acaggggtgt     1560

ggggacaggg gtcctgggga caggggtgtg gggacagggg tgtggggaca ggggtgtggg     1620

gacaggggtg tggggacagg ggtcctgggg ataggggtgt ggggacaggg gtgtggggac     1680

aggggtcccg gggacagggg tgtggggaca ggggtgtggg gacaggggtc ctggggacag     1740

gggtctgagg acaggggtgt gggcacaggg gtcctgggga caggggtcct ggggacaggg     1800

gtcctgggga caggggtctg gggacagcag cgcaaagagc cccgccctgc agcctccagc     1860

tctcctggtc taatgtggaa agtggcccag gtgagggctt tgctctcctg gagacatttg     1920

cccccagctg tgagcaggga caggtctggc caccgggccc ctggttaaga ctctaatgac     1980

ccgctggtcc tgaggaagag gtgctgacga ccaaggagat cttcccacag acccagcacc     2040

agggaaatgg tccggaaatt gcagcctcag cccccagcca tctgccgacc cccccacccc     2100

gccctaatgg gccaggcggc aggggttgac aggtagggga gatgggctct gagactataa     2160

agccagcggg ggcccagcag ccctcagccc tccaggacag gctgcatcag aagaggccat     2220

caagcaggtc tgttccaagg gcctttgcgt caggtgggct cagggttcca gggtggctgg     2280

accccaggcc ccagctctgc agcagggagg acgtggctgg gctcgtgaag catgtggggg     2340

tgagcccagg ggccccaagg cagggcacct ggccttcagc ctgcctcagc cctgcctgtc     2400

tcccagatca ctgtccttct gccatggccc tgtggatgcg cctcctgccc ctgctggcgc     2460

tgctggccct ctggggacct gacccagccg cagcctttgt gaaccaacac ctgtgcggct     2520

cacacctggt ggaagctctc tacctagtgt gcggggaacg aggcttcttc tacacaccca     2580

agacccgccg ggaggcagag gacctgcagg gtgagccaac cgcccattgc tgcccctggc     2640

cgcccccagc caccccctgc tcctggcgct cccacccagc atgggcagaa gggggcagga     2700

ggctgccacc cagcaggggg tcaggtgcac ttttttaaaa agaagttctc ttggtcacgt     2760

cctaaaagtg accagctccc tgtggcccag tcagaatctc agcctgagga cggtgttggc     2820

ttcggcagcc ccgagataca tcagagggtg ggcacgctcc tccctccact cgcccctcaa     2880

acaaatgccc cgcagcccat ttctccaccc tcatttgatg accgcagatt caagtgtttt     2940

gttaagtaaa gtcctgggtg acctggggtc acagggtgcc ccacgctgcc tgcctctggg     3000

cgaacacccc atcacgcccg gaggagggcg tggctgcctg cctgagtggg ccagacccct     3060

gtcgccagcc tcacggcagc tccatagtca ggagatgggg aagatgctgg ggacaggccc     3120

tggggagaag tactgggatc acctgttcag gctcccactg tgacgctgcc ccggggcggg     3180

ggaaggaggt gggacatgtg ggcgttgggg cctgtaggtc cacacccagt gtgggtgacc     3240

ctccctctaa cctgggtcca gcccggctgg agatgggtgg gagtgcgacc tagggctggc     3300

gggcaggcgg gcactgtgtc tccctgactg tgtcctcctg tgtccctctg cctcgccgct     3360

gttccggaac ctgctctgcg cggcacgtcc tggcagtggg gcaggtggag ctgggcgggg     3420

gccctggtgc aggcagcctg cagcccttgg ccctggaggg gtccctgcag aagcgtggca     3480

ttgtggaaca atgctgtacc agcatctgct ccctctacca gctggagaac tactgcaact     3540

agacgcagcc tgcaggcagc cccacacccg ccgcctcctg caccgagaga gatggaataa     3600

agcccttgaa ccagccctgc tgtgccgtct gtgtgtcttg ggggccctgg gccaagcccc     3660

acttcccggc actgttgtga gcccctccca gctctctcca cgctctctgg gtgcccacag     3720

gtgccaacgc cggccaggcc cagcatgcag tggctctccc caaagcggcc atgcctgttg     3780

gctgcctgct gcccccaccc tgtggctcag ggtccagtat gggagcttcg ggggtctctg     3840

aggggccagg gatggtgggg ccactgagaa gtgacttctt gttcagtagc tctggactct     3900

tggagtcccc agagaccttg ttcaggaaag ggaatgagaa cattccagca attttccccc     3960

cacctagccc tcccaggttc tatttttaga gttatttctg atggagtccc tgtggaggga     4020

ggaggctggg ctgagggagg gggtnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     4080

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     4140

nnnnctcgag ggaggagccc ggggctgggg tacggaggcc tctgcacatc ttagagtaaa     4200

acaagcagga gaggctgggt gcggtggctc atgcctataa tcccagcact ttaggaggct     4260

gaggcgggca gatcacctga ggtcgggagt tcaagaccag cctgaccaac agggagaaac     4320

cccatcttta ctaaaactac aaaattagct gggtgtggtg gcacatgcct gtaatcccag     4380

atattcggga ggctgaggca ggagaatcgc ttgaacctgg gaagcagagg ttgcgctgag     4440

ccgagatggc accattgcac tccagcctgg gcaacgagag cgaaactccg tctcaaaaaa     4500

acaaaaacaa aaaaatcaaa acaatcaaaa aaacaagcag gaggggctct gaggtgcctg     4560

caacacccag gtacaatccg tggccctgag gcccatcaca gggaaggggt ctttgcagct     4620

ctttcaaccc ccagcccagc atccaaggaa gcccagggca gggagaaacc tcagctgcac     4680

catcagagct cagaacagag aaggcagaaa ttagcaggga gtggggctgg ggaggcttcc     4740

tagaagacgt gtctcccgcc ttgctggcac tgaggccttg aggatgggtc catactgggc     4800

ccccactgcc agggatgcag atccggccca ctgctgaaat ctgtgctcct ggagcctccc     4860

tcctgttcat gggccacagg ctgtgaaaac cccagagtcc tcccaggcag caagttttgt     4920

tttgtttttt gtttgtttgc ttgtttgttt tttgagagtc tgctcgtca                 4969


<210>  4
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  5
<211>  767
<212>  DNA
<213>  Homo sapiens

<400>  5
gccgccccgc gagaagaaga gcgggaagag gcggacagcg aggccaagat ttcagctgcg       60

ggacggtcag gggagacctc caggcgcagg gaaggacggc cagggtgaca cggaagcatg      120

cgacggctgc tgatccctct ggccctgtgg ctgggtgcgg tgggcgtggg cgtcgccgag      180

ctcacggaag cccagcgccg gggcctgcag gtggccctgg aggaatttca caagcacccg      240

cccgtgcagt gggccttcca ggagaccagt gtggagagcg ccgtggacac gcccttccca      300

gctggaatat ttgtgaggct ggaatttaag ctgcagcaga caagctgccg gaagagggac      360

tggaagaaac ccgagtgcaa agtcaggccc aatgggagga aacggaaatg cctggcctgc      420

atcaaactgg gctctgagga caaagttctg ggccggttgg tccactgccc catagagacc      480

caagttctgc gggaggctga ggagcaccag gagacccagt gcctcagggt gcagcgggct      540

ggtgaggacc cccacagctt ctacttccct ggacagttcg ccttctccaa ggccctgccc      600

cgcagctaag ccagcactga gatgcgtggt gcctccagga ccgctgcggg tggtaaccag      660

tggaagaccc cagcccccag ggagaggaac ccgttctatc cccagccatg ataataaagc      720

tgctctccca gctgcctctc aaaaaaaaaa aaaaaaaaaa aaaaaaa                    767


<210>  6
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Arg Leu Leu Ile Pro Leu Ala Leu Trp Leu Gly Ala Val Gly 
1               5                   10                  15      


Val Gly Val Ala Glu Leu Thr Glu Ala Gln Arg Arg Gly Leu Gln Val 
            20                  25                  30          


Ala Leu Glu Glu Phe His Lys His Pro Pro Val Gln Trp Ala Phe Gln 
        35                  40                  45              


Glu Thr Ser Val Glu Ser Ala Val Asp Thr Pro Phe Pro Ala Gly Ile 
    50                  55                  60                  


Phe Val Arg Leu Glu Phe Lys Leu Gln Gln Thr Ser Cys Arg Lys Arg 
65                  70                  75                  80  


Asp Trp Lys Lys Pro Glu Cys Lys Val Arg Pro Asn Gly Arg Lys Arg 
                85                  90                  95      


Lys Cys Leu Ala Cys Ile Lys Leu Gly Ser Glu Asp Lys Val Leu Gly 
            100                 105                 110         


Arg Leu Val His Cys Pro Ile Glu Thr Gln Val Leu Arg Glu Ala Glu 
        115                 120                 125             


Glu His Gln Glu Thr Gln Cys Leu Arg Val Gln Arg Ala Gly Glu Asp 
    130                 135                 140                 


Pro His Ser Phe Tyr Phe Pro Gly Gln Phe Ala Phe Ser Lys Ala Leu 
145                 150                 155                 160 


Pro Arg Ser 
            


<210>  7
<211>  7415
<212>  DNA
<213>  Homo sapiens

<400>  7
gaaggcaaat gttcccccag ctgtttcctg tctacagtgt ctgtgttttg tagataaatg       60

tgaggatttt ctctaaatcc ctcttctgtt tgctaaatct cactgtcact gctaaattca      120

gagcagatag agcctgcgca atggaataaa gtcctcaaaa ttgaaatgtg acattgctct      180

caacatctcc catctctctg gatttctttt tgcttcatta ttcctgctaa ccaattcatt      240

ttcagacttt gtacttcaga agcaatggga aaaatcagca gtcttccaac ccaattattt      300

aagtgctgct tttgtgattt cttgaaggtg aagatgcaca ccatgtcctc ctcgcatctc      360

ttctacctgg cgctgtgcct gctcaccttc accagctctg ccacggctgg accggagacg      420

ctctgcgggg ctgagctggt ggatgctctt cagttcgtgt gtggagacag gggcttttat      480

ttcaacaagc ccacagggta tggctccagc agtcggaggg cgcctcagac aggcatcgtg      540

gatgagtgct gcttccggag ctgtgatcta aggaggctgg agatgtattg cgcacccctc      600

aagcctgcca agtcagctcg ctctgtccgt gcccagcgcc acaccgacat gcccaagacc      660

cagaagtatc agcccccatc taccaacaag aacacgaagt ctcagagaag gaaaggaagt      720

acatttgaag aacgcaagta gagggagtgc aggaaacaag aactacagga tgtaggaaga      780

ccctcctgag gagtgaagag tgacatgcca ccgcaggatc ctttgctctg cacgagttac      840

ctgttaaact ttggaacacc taccaaaaaa taagtttgat aacatttaaa agatgggcgt      900

ttcccccaat gaaatacaca agtaaacatt ccaacattgt ctttaggagt gatttgcacc      960

ttgcaaaaat ggtcctggag ttggtagatt gctgttgatc ttttatcaat aatgttctat     1020

agaaaagaaa aaaaaaatat atatatatat atatcttagt ccctgcctct caagagccac     1080

aaatgcatgg gtgttgtata gatccagttg cactaaattc ctctctgaat cttggctgct     1140

ggagccattc attcagcaac cttgtctaag tggtttatga attgtttcct tatttgcact     1200

tctttctaca caactcgggc tgtttgtttt acagtgtctg ataatcttgt tagtctatac     1260

ccaccacctc ccttcataac ctttatattt gccgaatttg gcctcctcaa aagcagcagc     1320

aagtcgtcaa gaagcacacc aattctaacc cacaagattc catctgtggc atttgtacca     1380

aatataagtt ggatgcattt tattttagac acaaagcttt atttttccac atcatgctta     1440

caaaaaagaa taatgcaaat agttgcaact ttgaggccaa tcatttttag gcatatgttt     1500

taaacataga aagtttcttc aactcaaaag agttccttca aatgatgagt taatgtgcaa     1560

cctaattagt aactttcctc tttttatttt ttccatatag agcactatgt aaatttagca     1620

tatcaattat acaggatata tcaaacagta tgtaaaactc tgttttttag tataatggtg     1680

ctattttgta gtttgttata tgaaagagtc tggccaaaac ggtaatacgt gaaagcaaaa     1740

caatagggga agcctggagc caaagatgac acaaggggaa gggtactgaa aacaccatcc     1800

atttgggaaa gaaggcaaag tccccccagt tatgccttcc aagaggaact tcagacacaa     1860

aagtccactg atgcaaattg gactggcgag tccagagagg aaactgtgga atggaaaaag     1920

cagaaggcta ggaattttag cagtcctggt ttctttttct catggaagaa atgaacatct     1980

gccagctgtg tcatggactc accactgtgt gaccttgggc aagtcacttc acctctctgt     2040

gcctcagttt cctcatctgc aaaatggggg caatatgtca tctacctacc tcaaaggggt     2100

ggtataaggt ttaaaaagat aaagattcag atttttttta ccctgggttg ctgtaagggt     2160

gcaacatcag ggcgcttgag ttgctgagat gcaaggaatt ctataaataa cccattcata     2220

gcatagctag agattggtga attgaatgct cctgacatct cagttcttgt cagtgaagct     2280

atccaaataa ctggccaact agttgttaaa agctaacagc tcaatctctt aaaacacttt     2340

tcaaaatatg tgggaagcat ttgattttca atttgatttt gaattctgca tttggtttta     2400

tgaatacaaa gataagtgaa aagagagaaa ggaaaagaaa aaggagaaaa acaaagagat     2460

ttctaccagt gaaaggggaa ttaattactc tttgttagca ctcactgact cttctatgca     2520

gttactacat atctagtaaa acctcgttta atactataaa taatattcta ttcattttga     2580

aaaacacaat gattccttct tttctaggca atataaggaa agtgatccaa aatttgaaat     2640

attaaaataa tatctaataa aaagtcacaa agttatcttc tttaacaaac tttactctta     2700

ttcttagctg tatatacatt tttttaaaag tttgttaaaa tatgcttgac tagagtttcc     2760

agttgaaagg caaaaacttc catcacaaca agaaatttcc catgcctgct cagaagggta     2820

gcccctagct ctctgtgaat gtgttttatc cattcaactg aaaattggta tcaagaaagt     2880

ccactggtta gtgtactagt ccatcatagc ctagaaaatg atccctatct gcagatcaag     2940

attttctcat tagaacaatg aattatccag cattcagatc tttctagtca ccttagaact     3000

ttttggttaa aagtacccag gcttgattat ttcatgcaaa ttctatattt tacattcttg     3060

gaaagtctat atgaaaaaca aaaataacat cttcagtttt tctcccactg ggtcacctca     3120

aggatcagag gccaggaaaa aaaaaaaaaa gactccctgg atctctgaat atatgcaaaa     3180

agaaggcccc atttagtgga gccagcaatc ctgttcagtc aacaagtatt ttaactctca     3240

gtccaacatt atttgaattg agcacctcaa gcatgcttag caatgttcta atcactatgg     3300

acagatgtaa aagaaactat acatcatttt tgccctctgc ctgttttcca gacatacagg     3360

ttctgtggaa taagatactg gactcctctt cccaagatgg cacttctttt tatttcttgt     3420

ccccagtgtg taccttttaa aattattccc tctcaacaaa actttatagg cagtcttctg     3480

cagacttaac gtgttttctg tcatagttag atgtgataat tctaagagtg tctatgactt     3540

atttccttca cttaattcta tccacagtca aaaatccccc aaggaggaaa gctgaaagat     3600

gcactgccat attatctttc ttaacttttt ccaacacata atcctctcca actggattat     3660

aaataaattg aaaataactc attataccaa ttcactattt tattttttaa tgaattaaaa     3720

ctagaaaaca aattgatgca aaccctggaa gtcagttgat tactatatac tacagcagaa     3780

tgactcagat ttcatagaaa ggagcaacca aaatgtcaca acccaaaact ttacaagctt     3840

tgcttcagaa ttagattgct ttataattct tgaatgaggc aatttcaaga tatttgtaaa     3900

agaacagtaa acattggtaa gaatgagctt tcaactcata ggcttatttc caatttaatt     3960

gaccatactg gatacttagg tcaaatttct gttctctctt ccccaaataa tattaaagta     4020

ttatttgaac tttttaagat gaggcagttc ccctgaaaaa gttaatgcag ctctccatca     4080

gaatccactc ttctagggat atgaaaatct cttaacaccc accctacata cacagacaca     4140

cacacacaca cacacacaca cacacacaca cacattcacc ctaaggatcc aatggaatac     4200

tgaaaagaaa tcacttcctt gaaaatttta ttaaaaaaca aacaaacaaa caaaaagcct     4260

gtccaccctt gagaatcctt cctctccttg gaacgtcaat gtttgtgtag atgaaaccat     4320

ctcatgctct gtggctccag ggtttctgtt actattttat gcacttggga gaaggcttag     4380

aataaaagat gtagcacatt ttgctttccc atttattgtt tggccagcta tgccaatgtg     4440

gtgctattgt ttctttaaga aagtacttga ctaaaaaaaa aagaaaaaaa gaaaaaaaag     4500

aaagcataga catatttttt taaagtataa aaacaacaat tctatagata gatggcttaa     4560

taaaatagca ttaggtctat ctagccacca ccacctttca actttttatc actcacaagt     4620

agtgtactgt tcaccaaatt gtgaatttgg gggtgcaggg gcaggagttg gaaatttttt     4680

aaagttagaa ggctccattg ttttgttggc tctcaaactt agcaaaatta gcaatatatt     4740

atccaatctt ctgaacttga tcaagagcat ggagaataaa cgcgggaaaa aagatcttat     4800

aggcaaatag aagaatttaa aagataagta agttccttat tgatttttgt gcactctgct     4860

ctaaaacaga tattcagcaa gtggagaaaa taagaacaaa gagaaaaaat acatagattt     4920

acctgcaaaa aatagcttct gccaaatccc ccttgggtat tctttggcat ttactggttt     4980

atagaagaca ttctcccttc acccagacat ctcaaagagc agtagctctc atgaaaagca     5040

atcactgatc tcatttggga aatgttggaa agtatttcct tatgagatgg gggttatcta     5100

ctgataaaga aagaatttat gagaaattgt tgaaagagat ggctaacaat ctgtgaagat     5160

tttttgtttc ttgtttttgt tttttttttt tttttacttt atacagtctt tatgaatttc     5220

ttaatgttca aaatgacttg gttcttttct tcttttttta tatcagaatg aggaataata     5280

agttaaaccc acatagactc tttaaaacta taggctagat agaaatgtat gtttgacttg     5340

ttgaagctat aatcagacta tttaaaatgt tttgctattt ttaatcttaa aagattgtgc     5400

taatttatta gagcagaacc tgtttggctc tcctcagaag aaagaatctt tccattcaaa     5460

tcacatggct ttccaccaat attttcaaaa gataaatctg atttatgcaa tggcatcatt     5520

tattttaaaa cagaagaatt gtgaaagttt atgcccctcc cttgcaaaga ccataaagtc     5580

cagatctggt aggggggcaa caacaaaagg aaaatgttgt tgattcttgg ttttggattt     5640

tgttttgttt tcaatgctag tgtttaatcc tgtagtacat atttgcttat tgctatttta     5700

atattttata agaccttcct gttaggtatt agaaagtgat acatagatat cttttttgtg     5760

taatttctat ttaaaaaaga gagaagactg tcagaagctt taagtgcata tggtacagga     5820

taaagatatc aatttaaata accaattcct atctggaaca atgcttttgt tttttaaaga     5880

aacctctcac agataagaca gaggcccagg ggatttttga agctgtcttt attctgcccc     5940

catcccaacc cagcccttat tattttagta tctgcctcag aattttatag agggctgacc     6000

aagctgaaac tctagaatta aaggaacctc actgaaaaca tatatttcac gtgttccctc     6060

tttttttttt tcctttttgt gagatggggt ctcgcactgt cccccaggct ggagtgcagt     6120

ggcatgatct cggctcactg caacctccac ctcctgggtt taagcgattc tcctgcctca     6180

gcctcctgag tagctgggat tacaggcacc caccactatg cccggctaat tttttggatt     6240

tttaatagag acggggtttt accatgttgg ccaggttggt ctcaaactcc tgaccttgtg     6300

atttgcccgc ctcagcctcc caaattgctg ggattacagg catgagccac cacaccctgc     6360

ccatgtgttc cctcttaatg tatgattaca tggatcttaa acatgatcct tctctcctca     6420

ttcttcaact atctttgatg gggtctttca aggggaaaaa aatccaagct tttttaaagt     6480

aaaaaaaaaa aaagagagga cacaaaacca aatgttactg ctcaactgaa atatgagtta     6540

agatggagac agagtttctc ctaataaccg gagctgaatt acctttcact ttcaaaaaca     6600

tgaccttcca caatccttag aatctgcctt tttttatatt actgaggcct aaaagtaaac     6660

attactcatt ttattttgcc caaaatgcac tgatgtaaag taggaaaaat aaaaacagag     6720

ctctaaaatc cctttcaagc cacccattga ccccactcac caactcatag caaagtcact     6780

tctgttaatc ccttaatctg attttgtttg gatatttatc ttgtacccgc tgctaaacac     6840

actgcaggag ggactctgaa acctcaagct gtctacttac atcttttatc tgtgtctgtg     6900

tatcatgaaa atgtctattc aaaatatcaa aacctttcaa atatcacgca gcttatattc     6960

agtttacata aaggccccaa ataccatgtc agatcttttt ggtaaaagag ttaatgaact     7020

atgagaattg ggattacatc atgtattttg cctcatgtat ttttatcaca cttataggcc     7080

aagtgtgata aataaactta cagacactga attaatttcc cctgctactt tgaaaccaga     7140

aaataatgac tggccattcg ttacatctgt cttagttgaa aagcatattt tttattaaat     7200

taattctgat tgtatttgaa attattattc aattcactta tggcagagga atatcaatcc     7260

taatgacttc taaaaatgta actaattgaa tcattatctt acatttactg tttaataagc     7320

atattttgaa aatgtatggc tagagtgtca taataaaatg gtatatcttt ctttagtaat     7380

tacattaaaa ttagtcatgt ttgattaatt agttc                                7415


<210>  8
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


