                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Inovio Pharmaceuticals, Inc.
       Weiner, David
       Muthumani, Kar
       Reuschel, Emma
       Jiang, Jingjing
       Ramos, Stephanie J
       Broderick, Kate
       Yan, Jian
 
<120>  VACCINES AGAINST MOSQUITO-BORNE VIRUSES, AND METHODS OF USING 
       SAME

<130>  206194-0022-00-WO.608584

<150>  US 62/622,322
<151>  2018-01-26

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  2820
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CHIKV Env3-Env2-Env1 (pGX4106)

<400>  1
tcactggcta ttcctgtcat gtgcctgctg gccaatacca cattcccatg cagccagccc       60

ccttgtactc catgctgtta cgagaaggaa cccgaggaaa ccctgcgaat gctggaggac      120

aacgtgatga ggcccgggta ctatcagctg ctgcaggcca gtctgacatg ctcacctcat      180

agacagagga gacggggccg gaagcgccga tctagtacaa aggacaactt caacgtgtac      240

aaagccacca ggccatacct ggctcactgc cccgattgtg gggagggcca ttcatgtcac      300

agccccgtgg ctctggagag gattagaaat gaagcaacag acggcactct gaagatccag      360

gtgagtctgc agatcggaat taagaccgac gattcacatg attggacaaa actgagatac      420

atggacaacc acatgccagc agatgctgag cgagcaggac tgttcgtgag gaccagcgcc      480

ccctgcacta ttaccggcac aatgggacac ttcatcctgg cccggtgtcc caagggagaa      540

actctgaccg tggggtttac tgactcccgc aaaatttcac atagctgcac ccaccctttc      600

caccatgatc cacccgtgat cgggagggag aagtttcatt ctagacctca gcacggcaaa      660

gaactgccat gttctaccta cgtgcagagt acagccgcta ctaccgagga aattgaggtc      720

cacatgcctc cagacacacc tgataggact ctgatgtccc agcagtctgg gaacgtgaag      780

atcactgtca atggccagac cgtgagatac aaatgcaact gtggcggatc taatgagggc      840

ctgacaacta ccgacaaagt gatcaacaat tgcaaagtcg atcagtgtca tgcagccgtg      900

accaaccaca agaaatggca gtataatagc ccactggtgc cccgaaacgc agagctggga      960

gaccgcaagg ggaaaatcca cattcctttc ccactggcaa atgtgacatg ccgagtccca     1020

aaggccagga atcccacagt gacttacggg aaaaaccagg tcatcatgct gctgtatcct     1080

gatcatccaa ccctgctgtc ttacaggaac atgggagagg aacctaatta tcaggaggaa     1140

tgggtcatgc acaagaaaga ggtggtcctg accgtgccaa cagagggcct ggaagtcaca     1200

tggggaaaca atgaacctta taagtactgg ccacagctgt ccactaacgg caccgcccac     1260

ggacatccac acgagatcat tctgtactat tacgaactgt atcccaccat gacagtggtc     1320

gtggtcagcg tggctacctt cattctgctg tccatggtcg ggatggctgc aggcatgtgc     1380

atgtgcgcaa ggagacggtg catcacaccc tacgagctga cccctggagc cacagtgcca     1440

tttctgctgt ctctgatttg ctgtatccgg actgcaaagg ccaggggcag gaaacgccga     1500

agttatgaac acgtgactgt catccctaat accgtgggag tcccatacaa gaccctggtg     1560

aaccgccccg ggtattcccc tatggtgctg gagatggaac tgctgtctgt cactctggag     1620

cccaccctga gtctggacta tattacatgc gaatacaaga ctgtgatccc ctcaccttac     1680

gtcaaatgct gtggcactgc cgagtgcaag gacaaaaatc tgcctgatta tagctgtaag     1740

gtgttcaccg gagtctatcc cttcatgtgg ggcggcgcct actgcttctg tgatgccgag     1800

aacacccagc tgagcgaagc tcatgtggag aagtccgaat cttgtaaaac agagtttgct     1860

tccgcatacc gcgcacacac tgccagtgct tcagcaaagc tgcgagtgct gtaccagggc     1920

aacaatatca ctgtcaccgc ctatgctaac ggagaccacg ctgtgaccgt caaggatgca     1980

aaattcattg tgggacccat gagctccgcc tggacacctt ttgacaataa gatcgtggtc     2040

tacaaagggg acgtgtataa catggattac cctcccttcg gcgctgggag acccggacag     2100

tttggcgaca ttcagtcacg gacccctgag agcaaggacg tgtacgctaa tacacagctg     2160

gtgctgcagc gacctgcagt cggcacagtg catgtcccct acagccaggc cccttccgga     2220

ttcaagtatt ggctgaaaga aaggggcgcc agtctgcagc acactgctcc atttgggtgc     2280

cagatcgcta ccaaccccgt gcgcgctgtc aactgtgcag tgggcaatat gcccatctcc     2340

attgacatcc ctgaggccgc tttcacaaga gtggtcgacg ccccttccct gactgatatg     2400

tcttgcgaag tgccagcctg tacccattct agtgattttg gaggggtggc tatcattaag     2460

tacgcagcct caaagaaagg caaatgcgcc gtgcacagca tgacaaatgc agtcactatt     2520

agggaggccg aaatcgaggt ggaaggcaac agccagctgc agattagctt ctccacagca     2580

ctggcctccg ctgagtttag agtgcaggtc tgttctactc aggtgcattg cgctgcagaa     2640

tgtcatccac ccaaggacca catcgtgaac tatccagcct cccacacaac tctgggcgtc     2700

caggatatta gtgcaaccgc catgtcatgg gtgcagaaaa tcacaggcgg agtcggactg     2760

gtcgtcgccg tcgctgccct gattctgatc gtggtcctgt gcgtgtcctt tagtcgccat     2820


<210>  2
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CHIKV Env3-Env2-Env1 (pGX4106)

<400>  2

Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr Phe Pro 
1               5                   10                  15      


Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu 
            20                  25                  30          


Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr 
        35                  40                  45              


Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg 
    50                  55                  60                  


Arg Gly Arg Lys Arg Arg Ser Ser Thr Lys Asp Asn Phe Asn Val Tyr 
65                  70                  75                  80  


Lys Ala Thr Arg Pro Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly 
                85                  90                  95      


His Ser Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg Asn Glu Ala 
            100                 105                 110         


Thr Asp Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile Gly Ile Lys 
        115                 120                 125             


Thr Asp Asp Ser His Asp Trp Thr Lys Leu Arg Tyr Met Asp Asn His 
    130                 135                 140                 


Met Pro Ala Asp Ala Glu Arg Ala Gly Leu Phe Val Arg Thr Ser Ala 
145                 150                 155                 160 


Pro Cys Thr Ile Thr Gly Thr Met Gly His Phe Ile Leu Ala Arg Cys 
                165                 170                 175     


Pro Lys Gly Glu Thr Leu Thr Val Gly Phe Thr Asp Ser Arg Lys Ile 
            180                 185                 190         


Ser His Ser Cys Thr His Pro Phe His His Asp Pro Pro Val Ile Gly 
        195                 200                 205             


Arg Glu Lys Phe His Ser Arg Pro Gln His Gly Lys Glu Leu Pro Cys 
    210                 215                 220                 


Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu Ile Glu Val 
225                 230                 235                 240 


His Met Pro Pro Asp Thr Pro Asp Arg Thr Leu Met Ser Gln Gln Ser 
                245                 250                 255     


Gly Asn Val Lys Ile Thr Val Asn Gly Gln Thr Val Arg Tyr Lys Cys 
            260                 265                 270         


Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr Thr Thr Asp Lys Val Ile 
        275                 280                 285             


Asn Asn Cys Lys Val Asp Gln Cys His Ala Ala Val Thr Asn His Lys 
    290                 295                 300                 


Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala Glu Leu Gly 
305                 310                 315                 320 


Asp Arg Lys Gly Lys Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr 
                325                 330                 335     


Cys Arg Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr Gly Lys Asn 
            340                 345                 350         


Gln Val Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu Leu Ser Tyr 
        355                 360                 365             


Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu Trp Val Met His 
    370                 375                 380                 


Lys Lys Glu Val Val Leu Thr Val Pro Thr Glu Gly Leu Glu Val Thr 
385                 390                 395                 400 


Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln Leu Ser Thr Asn 
                405                 410                 415     


Gly Thr Ala His Gly His Pro His Glu Ile Ile Leu Tyr Tyr Tyr Glu 
            420                 425                 430         


Leu Tyr Pro Thr Met Thr Val Val Val Val Ser Val Ala Thr Phe Ile 
        435                 440                 445             


Leu Leu Ser Met Val Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg 
    450                 455                 460                 


Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala Thr Val Pro 
465                 470                 475                 480 


Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala Lys Ala Arg Gly 
                485                 490                 495     


Arg Lys Arg Arg Ser Tyr Glu His Val Thr Val Ile Pro Asn Thr Val 
            500                 505                 510         


Gly Val Pro Tyr Lys Thr Leu Val Asn Arg Pro Gly Tyr Ser Pro Met 
        515                 520                 525             


Val Leu Glu Met Glu Leu Leu Ser Val Thr Leu Glu Pro Thr Leu Ser 
    530                 535                 540                 


Leu Asp Tyr Ile Thr Cys Glu Tyr Lys Thr Val Ile Pro Ser Pro Tyr 
545                 550                 555                 560 


Val Lys Cys Cys Gly Thr Ala Glu Cys Lys Asp Lys Asn Leu Pro Asp 
                565                 570                 575     


Tyr Ser Cys Lys Val Phe Thr Gly Val Tyr Pro Phe Met Trp Gly Gly 
            580                 585                 590         


Ala Tyr Cys Phe Cys Asp Ala Glu Asn Thr Gln Leu Ser Glu Ala His 
        595                 600                 605             


Val Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg 
    610                 615                 620                 


Ala His Thr Ala Ser Ala Ser Ala Lys Leu Arg Val Leu Tyr Gln Gly 
625                 630                 635                 640 


Asn Asn Ile Thr Val Thr Ala Tyr Ala Asn Gly Asp His Ala Val Thr 
                645                 650                 655     


Val Lys Asp Ala Lys Phe Ile Val Gly Pro Met Ser Ser Ala Trp Thr 
            660                 665                 670         


Pro Phe Asp Asn Lys Ile Val Val Tyr Lys Gly Asp Val Tyr Asn Met 
        675                 680                 685             


Asp Tyr Pro Pro Phe Gly Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile 
    690                 695                 700                 


Gln Ser Arg Thr Pro Glu Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu 
705                 710                 715                 720 


Val Leu Gln Arg Pro Ala Val Gly Thr Val His Val Pro Tyr Ser Gln 
                725                 730                 735     


Ala Pro Ser Gly Phe Lys Tyr Trp Leu Lys Glu Arg Gly Ala Ser Leu 
            740                 745                 750         


Gln His Thr Ala Pro Phe Gly Cys Gln Ile Ala Thr Asn Pro Val Arg 
        755                 760                 765             


Ala Val Asn Cys Ala Val Gly Asn Met Pro Ile Ser Ile Asp Ile Pro 
    770                 775                 780                 


Glu Ala Ala Phe Thr Arg Val Val Asp Ala Pro Ser Leu Thr Asp Met 
785                 790                 795                 800 


Ser Cys Glu Val Pro Ala Cys Thr His Ser Ser Asp Phe Gly Gly Val 
                805                 810                 815     


Ala Ile Ile Lys Tyr Ala Ala Ser Lys Lys Gly Lys Cys Ala Val His 
            820                 825                 830         


Ser Met Thr Asn Ala Val Thr Ile Arg Glu Ala Glu Ile Glu Val Glu 
        835                 840                 845             


Gly Asn Ser Gln Leu Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala 
    850                 855                 860                 


Glu Phe Arg Val Gln Val Cys Ser Thr Gln Val His Cys Ala Ala Glu 
865                 870                 875                 880 


Cys His Pro Pro Lys Asp His Ile Val Asn Tyr Pro Ala Ser His Thr 
                885                 890                 895     


Thr Leu Gly Val Gln Asp Ile Ser Ala Thr Ala Met Ser Trp Val Gln 
            900                 905                 910         


Lys Ile Thr Gly Gly Val Gly Leu Val Val Ala Val Ala Ala Leu Ile 
        915                 920                 925             


Leu Ile Val Val Leu Cys Val Ser Phe Ser Arg His 
    930                 935                 940 


<210>  3
<211>  2880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of CHIKV Env3-Env2-Env1 (pGX4106) operably 
       linked to a sequence encoding an IgE leader and two stop codons

<400>  3
atggactgga cctggattct gtttctggtc gccgccgcaa ctcgggtgca ttcctcactg       60

gctattcctg tcatgtgcct gctggccaat accacattcc catgcagcca gcccccttgt      120

actccatgct gttacgagaa ggaacccgag gaaaccctgc gaatgctgga ggacaacgtg      180

atgaggcccg ggtactatca gctgctgcag gccagtctga catgctcacc tcatagacag      240

aggagacggg gccggaagcg ccgatctagt acaaaggaca acttcaacgt gtacaaagcc      300

accaggccat acctggctca ctgccccgat tgtggggagg gccattcatg tcacagcccc      360

gtggctctgg agaggattag aaatgaagca acagacggca ctctgaagat ccaggtgagt      420

ctgcagatcg gaattaagac cgacgattca catgattgga caaaactgag atacatggac      480

aaccacatgc cagcagatgc tgagcgagca ggactgttcg tgaggaccag cgccccctgc      540

actattaccg gcacaatggg acacttcatc ctggcccggt gtcccaaggg agaaactctg      600

accgtggggt ttactgactc ccgcaaaatt tcacatagct gcacccaccc tttccaccat      660

gatccacccg tgatcgggag ggagaagttt cattctagac ctcagcacgg caaagaactg      720

ccatgttcta cctacgtgca gagtacagcc gctactaccg aggaaattga ggtccacatg      780

cctccagaca cacctgatag gactctgatg tcccagcagt ctgggaacgt gaagatcact      840

gtcaatggcc agaccgtgag atacaaatgc aactgtggcg gatctaatga gggcctgaca      900

actaccgaca aagtgatcaa caattgcaaa gtcgatcagt gtcatgcagc cgtgaccaac      960

cacaagaaat ggcagtataa tagcccactg gtgccccgaa acgcagagct gggagaccgc     1020

aaggggaaaa tccacattcc tttcccactg gcaaatgtga catgccgagt cccaaaggcc     1080

aggaatccca cagtgactta cgggaaaaac caggtcatca tgctgctgta tcctgatcat     1140

ccaaccctgc tgtcttacag gaacatggga gaggaaccta attatcagga ggaatgggtc     1200

atgcacaaga aagaggtggt cctgaccgtg ccaacagagg gcctggaagt cacatgggga     1260

aacaatgaac cttataagta ctggccacag ctgtccacta acggcaccgc ccacggacat     1320

ccacacgaga tcattctgta ctattacgaa ctgtatccca ccatgacagt ggtcgtggtc     1380

agcgtggcta ccttcattct gctgtccatg gtcgggatgg ctgcaggcat gtgcatgtgc     1440

gcaaggagac ggtgcatcac accctacgag ctgacccctg gagccacagt gccatttctg     1500

ctgtctctga tttgctgtat ccggactgca aaggccaggg gcaggaaacg ccgaagttat     1560

gaacacgtga ctgtcatccc taataccgtg ggagtcccat acaagaccct ggtgaaccgc     1620

cccgggtatt cccctatggt gctggagatg gaactgctgt ctgtcactct ggagcccacc     1680

ctgagtctgg actatattac atgcgaatac aagactgtga tcccctcacc ttacgtcaaa     1740

tgctgtggca ctgccgagtg caaggacaaa aatctgcctg attatagctg taaggtgttc     1800

accggagtct atcccttcat gtggggcggc gcctactgct tctgtgatgc cgagaacacc     1860

cagctgagcg aagctcatgt ggagaagtcc gaatcttgta aaacagagtt tgcttccgca     1920

taccgcgcac acactgccag tgcttcagca aagctgcgag tgctgtacca gggcaacaat     1980

atcactgtca ccgcctatgc taacggagac cacgctgtga ccgtcaagga tgcaaaattc     2040

attgtgggac ccatgagctc cgcctggaca ccttttgaca ataagatcgt ggtctacaaa     2100

ggggacgtgt ataacatgga ttaccctccc ttcggcgctg ggagacccgg acagtttggc     2160

gacattcagt cacggacccc tgagagcaag gacgtgtacg ctaatacaca gctggtgctg     2220

cagcgacctg cagtcggcac agtgcatgtc ccctacagcc aggccccttc cggattcaag     2280

tattggctga aagaaagggg cgccagtctg cagcacactg ctccatttgg gtgccagatc     2340

gctaccaacc ccgtgcgcgc tgtcaactgt gcagtgggca atatgcccat ctccattgac     2400

atccctgagg ccgctttcac aagagtggtc gacgcccctt ccctgactga tatgtcttgc     2460

gaagtgccag cctgtaccca ttctagtgat tttggagggg tggctatcat taagtacgca     2520

gcctcaaaga aaggcaaatg cgccgtgcac agcatgacaa atgcagtcac tattagggag     2580

gccgaaatcg aggtggaagg caacagccag ctgcagatta gcttctccac agcactggcc     2640

tccgctgagt ttagagtgca ggtctgttct actcaggtgc attgcgctgc agaatgtcat     2700

ccacccaagg accacatcgt gaactatcca gcctcccaca caactctggg cgtccaggat     2760

attagtgcaa ccgccatgtc atgggtgcag aaaatcacag gcggagtcgg actggtcgtc     2820

gccgtcgctg ccctgattct gatcgtggtc ctgtgcgtgt cctttagtcg ccattgataa     2880


<210>  4
<211>  958
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CHIKV Env3-Env2-Env1 operably linked to an
       IgE leader sequence (pGX4106)

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr 
            20                  25                  30          


Phe Pro Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu 
        35                  40                  45              


Pro Glu Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly 
    50                  55                  60                  


Tyr Tyr Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln 
65                  70                  75                  80  


Arg Arg Arg Gly Arg Lys Arg Arg Ser Ser Thr Lys Asp Asn Phe Asn 
                85                  90                  95      


Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys Pro Asp Cys Gly 
            100                 105                 110         


Glu Gly His Ser Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg Asn 
        115                 120                 125             


Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile Gly 
    130                 135                 140                 


Ile Lys Thr Asp Asp Ser His Asp Trp Thr Lys Leu Arg Tyr Met Asp 
145                 150                 155                 160 


Asn His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu Phe Val Arg Thr 
                165                 170                 175     


Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His Phe Ile Leu Ala 
            180                 185                 190         


Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe Thr Asp Ser Arg 
        195                 200                 205             


Lys Ile Ser His Ser Cys Thr His Pro Phe His His Asp Pro Pro Val 
    210                 215                 220                 


Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His Gly Lys Glu Leu 
225                 230                 235                 240 


Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu Ile 
                245                 250                 255     


Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr Leu Met Ser Gln 
            260                 265                 270         


Gln Ser Gly Asn Val Lys Ile Thr Val Asn Gly Gln Thr Val Arg Tyr 
        275                 280                 285             


Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr Thr Thr Asp Lys 
    290                 295                 300                 


Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala Ala Val Thr Asn 
305                 310                 315                 320 


His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala Glu 
                325                 330                 335     


Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe Pro Leu Ala Asn 
            340                 345                 350         


Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr Gly 
        355                 360                 365             


Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu Leu 
    370                 375                 380                 


Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu Trp Val 
385                 390                 395                 400 


Met His Lys Lys Glu Val Val Leu Thr Val Pro Thr Glu Gly Leu Glu 
                405                 410                 415     


Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln Leu Ser 
            420                 425                 430         


Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile Ile Leu Tyr Tyr 
        435                 440                 445             


Tyr Glu Leu Tyr Pro Thr Met Thr Val Val Val Val Ser Val Ala Thr 
    450                 455                 460                 


Phe Ile Leu Leu Ser Met Val Gly Met Ala Ala Gly Met Cys Met Cys 
465                 470                 475                 480 


Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala Thr 
                485                 490                 495     


Val Pro Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala Lys Ala 
            500                 505                 510         


Arg Gly Arg Lys Arg Arg Ser Tyr Glu His Val Thr Val Ile Pro Asn 
        515                 520                 525             


Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn Arg Pro Gly Tyr Ser 
    530                 535                 540                 


Pro Met Val Leu Glu Met Glu Leu Leu Ser Val Thr Leu Glu Pro Thr 
545                 550                 555                 560 


Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr Lys Thr Val Ile Pro Ser 
                565                 570                 575     


Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu Cys Lys Asp Lys Asn Leu 
            580                 585                 590         


Pro Asp Tyr Ser Cys Lys Val Phe Thr Gly Val Tyr Pro Phe Met Trp 
        595                 600                 605             


Gly Gly Ala Tyr Cys Phe Cys Asp Ala Glu Asn Thr Gln Leu Ser Glu 
    610                 615                 620                 


Ala His Val Glu Lys Ser Glu Ser Cys Lys Thr Glu Phe Ala Ser Ala 
625                 630                 635                 640 


Tyr Arg Ala His Thr Ala Ser Ala Ser Ala Lys Leu Arg Val Leu Tyr 
                645                 650                 655     


Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala Asn Gly Asp His Ala 
            660                 665                 670         


Val Thr Val Lys Asp Ala Lys Phe Ile Val Gly Pro Met Ser Ser Ala 
        675                 680                 685             


Trp Thr Pro Phe Asp Asn Lys Ile Val Val Tyr Lys Gly Asp Val Tyr 
    690                 695                 700                 


Asn Met Asp Tyr Pro Pro Phe Gly Ala Gly Arg Pro Gly Gln Phe Gly 
705                 710                 715                 720 


Asp Ile Gln Ser Arg Thr Pro Glu Ser Lys Asp Val Tyr Ala Asn Thr 
                725                 730                 735     


Gln Leu Val Leu Gln Arg Pro Ala Val Gly Thr Val His Val Pro Tyr 
            740                 745                 750         


Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu Lys Glu Arg Gly Ala 
        755                 760                 765             


Ser Leu Gln His Thr Ala Pro Phe Gly Cys Gln Ile Ala Thr Asn Pro 
    770                 775                 780                 


Val Arg Ala Val Asn Cys Ala Val Gly Asn Met Pro Ile Ser Ile Asp 
785                 790                 795                 800 


Ile Pro Glu Ala Ala Phe Thr Arg Val Val Asp Ala Pro Ser Leu Thr 
                805                 810                 815     


Asp Met Ser Cys Glu Val Pro Ala Cys Thr His Ser Ser Asp Phe Gly 
            820                 825                 830         


Gly Val Ala Ile Ile Lys Tyr Ala Ala Ser Lys Lys Gly Lys Cys Ala 
        835                 840                 845             


Val His Ser Met Thr Asn Ala Val Thr Ile Arg Glu Ala Glu Ile Glu 
    850                 855                 860                 


Val Glu Gly Asn Ser Gln Leu Gln Ile Ser Phe Ser Thr Ala Leu Ala 
865                 870                 875                 880 


Ser Ala Glu Phe Arg Val Gln Val Cys Ser Thr Gln Val His Cys Ala 
                885                 890                 895     


Ala Glu Cys His Pro Pro Lys Asp His Ile Val Asn Tyr Pro Ala Ser 
            900                 905                 910         


His Thr Thr Leu Gly Val Gln Asp Ile Ser Ala Thr Ala Met Ser Trp 
        915                 920                 925             


Val Gln Lys Ile Thr Gly Gly Val Gly Leu Val Val Ala Val Ala Ala 
    930                 935                 940                 


Leu Ile Leu Ile Val Val Leu Cys Val Ser Phe Ser Arg His 
945                 950                 955             


<210>  5
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DENV 1 prME

<400>  5
aataggagga agaggagcgt cacaatgctg ctgatgctga tgcccaccgc cctggctttc       60

cacctgacca cacggggcgg ggagcctcat atgatcgtgt ccaagcagga aagagggaaa      120

tccctgctgt ttaagacttc tgccggagtg aacatgtgca ccctgattgc tatggacctg      180

ggcgagctgt gcgaagatac catgacatac aagtgtccaa ggatcacaga ggccgaaccc      240

gacgatgtgg actgctggtg taatgctact gatacctggg tgacctatgg gacatgttca      300

cagaccggag agcaccggag agacaagagg agcgtggcac tggcccctca cgtcggactg      360

ggactggaga cacgcactga aacctggatg agctccgagg gggcctggaa acagattcag      420

agagtggaaa cctgggctct gaggcaccct ggattcacag tgatcgcact gtttctggct      480

catgcaattg gaacttctat cacccagaag ggcatcattt tcattctgct gatgctggtg      540

accccaagta tggcaatgcg atgcgtggga atcggaaacc gagactttgt cgagggcctg      600

tccggggcta catgggtgga tgtggtcctg gaacacggct cttgtgtcac taccatggca      660

aaggacaaac caaccctgga tatcgagctg ctgaagacag aagtgactaa ccccgcagtc      720

ctgcgaaaac tgtgcattga ggccaagatc agtaatacaa ctaccgattc acgctgtccc      780

actcagggcg aagctaccct ggtggaggaa caggacgcaa acttcgtgtg caggcgcacc      840

tttgtcgatc gcggatgggg caatgggtgt ggactgttcg gcaaggggtc cctgatcaca      900

tgcgccaagt ttaaatgtgt gactaagctg gagggcaaaa ttgtccagta cgaaaacctg      960

aaatattcag tcatcgtgac cgtccacaca ggcgaccagc atcaagtggg gaatgagtct     1020

accgaacacg ggacaactgc aacaattact cctcaggccc caacaagcga gatccagctg     1080

actgactacg gagccctgac cctggattgc tcccctcgga ccggactgga tttcaacgag     1140

atggtgctgc tgacaatgaa ggaaaaaagt tggctggtgc ataagcagtg gtttctggac     1200

ctgccactgc cctggacatc tggcgcctca acaagccagg agacttggaa tagacaggat     1260

ctgctggtga ctttcaagac cgcccacgct aagaaacagg aggtggtcgt gctgggcagc     1320

caggaaggag ctatgcatac agcactgact ggcgccaccg agattcagac cagcgggacc     1380

acaactatct tcgccggaca cctgaagtgc cggctgaaga tggacaaact gacactgaaa     1440

ggaatgagct acgtgatgtg tactggctcc tttaagctgg agaaagaagt ggctgagacc     1500

cagcatggca cagtgctggt ccaggtgaaa tatgaaggga ccgacgcccc ctgtaagatc     1560

cctttcagca cccaggatga gaaaggagtg acacagaacg gcaggctgat tacagcaaat     1620

cctatcgtga ctgataagga aaaaccagtc aacattgagg ccgaaccccc ttttggcgag     1680

agttacatcg tcgtgggagc tggcgaaaag gcactgaaac tgtcatggtt caagaaaggg     1740

tctagtattg gaaagatgtt tgaggcaacc gccagaggcg cccgacgaat ggctattctg     1800

ggcgacactg cttgggattt cgggtctatc ggaggcgtct ttaccagtgt gggcaagctg     1860

gtccaccaga tcttcggcac agcctatggg gtgctgtttt caggggtcag ctggactatg     1920

aaaatcggga ttggaatcct gctgacttgg ctgggactga attccagatc taccagtctg     1980

agcatgactt gtattgccgt cggactggtg acactgtatc tgggcgtgat ggtgcaggcc     2040


<210>  6
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV 1 prME

<400>  6

Asn Arg Arg Lys Arg Ser Val Thr Met Leu Leu Met Leu Met Pro Thr 
1               5                   10                  15      


Ala Leu Ala Phe His Leu Thr Thr Arg Gly Gly Glu Pro His Met Ile 
            20                  25                  30          


Val Ser Lys Gln Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ser Ala 
        35                  40                  45              


Gly Val Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Leu Cys 
    50                  55                  60                  


Glu Asp Thr Met Thr Tyr Lys Cys Pro Arg Ile Thr Glu Ala Glu Pro 
65                  70                  75                  80  


Asp Asp Val Asp Cys Trp Cys Asn Ala Thr Asp Thr Trp Val Thr Tyr 
                85                  90                  95      


Gly Thr Cys Ser Gln Thr Gly Glu His Arg Arg Asp Lys Arg Ser Val 
            100                 105                 110         


Ala Leu Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Thr Glu Thr 
        115                 120                 125             


Trp Met Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Arg Val Glu Thr 
    130                 135                 140                 


Trp Ala Leu Arg His Pro Gly Phe Thr Val Ile Ala Leu Phe Leu Ala 
145                 150                 155                 160 


His Ala Ile Gly Thr Ser Ile Thr Gln Lys Gly Ile Ile Phe Ile Leu 
                165                 170                 175     


Leu Met Leu Val Thr Pro Ser Met Ala Met Arg Cys Val Gly Ile Gly 
            180                 185                 190         


Asn Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val 
        195                 200                 205             


Val Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asp Lys Pro 
    210                 215                 220                 


Thr Leu Asp Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val 
225                 230                 235                 240 


Leu Arg Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp 
                245                 250                 255     


Ser Arg Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp 
            260                 265                 270         


Ala Asn Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly Trp Gly Asn 
        275                 280                 285             


Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe 
    290                 295                 300                 


Lys Cys Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu 
305                 310                 315                 320 


Lys Tyr Ser Val Ile Val Thr Val His Thr Gly Asp Gln His Gln Val 
                325                 330                 335     


Gly Asn Glu Ser Thr Glu His Gly Thr Thr Ala Thr Ile Thr Pro Gln 
            340                 345                 350         


Ala Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Ala Leu Thr Leu 
        355                 360                 365             


Asp Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu 
    370                 375                 380                 


Thr Met Lys Glu Lys Ser Trp Leu Val His Lys Gln Trp Phe Leu Asp 
385                 390                 395                 400 


Leu Pro Leu Pro Trp Thr Ser Gly Ala Ser Thr Ser Gln Glu Thr Trp 
                405                 410                 415     


Asn Arg Gln Asp Leu Leu Val Thr Phe Lys Thr Ala His Ala Lys Lys 
            420                 425                 430         


Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala 
        435                 440                 445             


Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly Thr Thr Thr Ile Phe 
    450                 455                 460                 


Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Thr Leu Lys 
465                 470                 475                 480 


Gly Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu 
                485                 490                 495     


Val Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu 
            500                 505                 510         


Gly Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys 
        515                 520                 525             


Gly Val Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr 
    530                 535                 540                 


Asp Lys Glu Lys Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu 
545                 550                 555                 560 


Ser Tyr Ile Val Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp 
                565                 570                 575     


Phe Lys Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg 
            580                 585                 590         


Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly 
        595                 600                 605             


Ser Ile Gly Gly Val Phe Thr Ser Val Gly Lys Leu Val His Gln Ile 
    610                 615                 620                 


Phe Gly Thr Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met 
625                 630                 635                 640 


Lys Ile Gly Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg 
                645                 650                 655     


Ser Thr Ser Leu Ser Met Thr Cys Ile Ala Val Gly Leu Val Thr Leu 
            660                 665                 670         


Tyr Leu Gly Val Met Val Gln Ala 
        675                 680 


<210>  7
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DENV 2 prME

<400>  7
aatagacgga gacggagtgc cgggatgatt atcatgctga ttccaaccgt gatggctttc       60

cacctgacca caaggaacgg cgagccccat atgatcgtgg gacgccagga aaagggcaaa      120

tccctgctgt ttaaaactga ggacggagtg aatatgtgca ccctgatggc aattgacctg      180

ggcgagctgt gcgaagatac tatcacctac aagtgtccac tgctgaggca gaacgagccc      240

gaagacatcg attgctggtg taatagtaca tcaacttggg tgacttatgg cacctgtact      300

accacagggg agcaccggag agaaaagaga tctgtcgctc tggtgcccca tgtcggcatg      360

gggctggaga ccaggacaga aacttggatg agctccgagg gcgcatggaa gcacgtgcag      420

cgcattgaaa catggattct gcgacatcct gggttcacta ttatggccgc tatcctggcc      480

tacaccattg gaactaccca cttccagcgc gctctgattt ttatcctgct gacagctgtg      540

gcaccatcca tgactatgcg gtgcattggc atctctaaca gagacttcgt ggagggggtc      600

agcggcgggt cctgggtgga tatcgtcctg gaacatggca gctgtgtgac aactatggca      660

aagaacaagc ctaccctgga ttttgagctg atcaagaccg aagccaagca gccagctaca      720

ctgcgcaaat attgcatcga ggccaagctg accaacacca caactgagag tcgatgtccc      780

acacaggggg aaccttcact gaatgaggaa caggacaaac gatttgtgtg caagcacagc      840

atggtcgatc ggggatgggg caacgggtgt ggactgttcg gaaaaggagg cattgtgaca      900

tgcgccatgt ttacttgtaa gaaaaacatg gagggcaaga tcgtgcagcc cgagaatctg      960

gaatacacca ttgtcatcac acctcactcc ggagaggaac atgccgtggg caatgacact     1020

gggaagcacg gaaaagagat taaggtcacc cctcagtcta gtatcaccga ggctgaactg     1080

acaggctatg ggaccgtgac aatggaatgc tctcctcgga caggcctgga tttcaacgag     1140

atggtgctgc tgcagatgga aaataaggca tggctggtcc atagacagtg gtttctggac     1200

ctgccactgc catggctgcc aggagcagat acccagggat ctaactggat tcagaaagag     1260

acactggtga ctttcaagaa tccccacgcc aagaaacagg acgtggtcgt gctgggcagt     1320

caggagggag caatgcatac cgccctgaca ggcgctactg aaatccagat gtcaagcggg     1380

aacctgctgt tcacaggaca cctgaaatgc aggctgcgca tggataaact gcagctgaag     1440

gggatgagct actccatgtg taccggaaag tttaaagtcg tgaaggagat cgccgaaact     1500

cagcacggca ccattgtgat ccgggtccag tatgagggag acggcagccc ttgtaaaatt     1560

ccattcgaga tcatggatct ggaaaagaga catgtgctgg ggaggctgat tactgtgaac     1620

cctatcgtca ccgagaagga cagcccagtg aatatcgagg ctgaaccccc ttttggagat     1680

tcctacatca ttatcggagt ggagcctggc cagctgaaac tgaactggtt caagaaaggg     1740

tcctctattg gacagatgtt tgaaaccaca atgcgaggcg caaagcggat ggccatcctg     1800

ggcgacacag cctgggattt cgggtcactg ggcggcgtgt tcaccagcat tggcaaagct     1860

ctgcaccagg tcttcggcgc aatctatggg gcagcctttt ctggggtgag ttggaccatg     1920

aagattctga tcggagtcat tatcacatgg atcggcatga attctagaag tacttcactg     1980

tccgtgagcc tggtcctggt cggcgtggtg acactgtatc tgggcgtgat ggtgcaggcc     2040


<210>  8
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV 2 prME

<400>  8

Asn Arg Arg Arg Arg Ser Ala Gly Met Ile Ile Met Leu Ile Pro Thr 
1               5                   10                  15      


Val Met Ala Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile 
            20                  25                  30          


Val Gly Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp 
        35                  40                  45              


Gly Val Asn Met Cys Thr Leu Met Ala Ile Asp Leu Gly Glu Leu Cys 
    50                  55                  60                  


Glu Asp Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr 
                85                  90                  95      


Gly Thr Cys Thr Thr Thr Gly Glu His Arg Arg Glu Lys Arg Ser Val 
            100                 105                 110         


Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr 
        115                 120                 125             


Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr 
    130                 135                 140                 


Trp Ile Leu Arg His Pro Gly Phe Thr Ile Met Ala Ala Ile Leu Ala 
145                 150                 155                 160 


Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu 
                165                 170                 175     


Leu Thr Ala Val Ala Pro Ser Met Thr Met Arg Cys Ile Gly Ile Ser 
            180                 185                 190         


Asn Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ser Trp Val Asp Ile 
        195                 200                 205             


Val Leu Glu His Gly Ser Cys Val Thr Thr Met Ala Lys Asn Lys Pro 
    210                 215                 220                 


Thr Leu Asp Phe Glu Leu Ile Lys Thr Glu Ala Lys Gln Pro Ala Thr 
225                 230                 235                 240 


Leu Arg Lys Tyr Cys Ile Glu Ala Lys Leu Thr Asn Thr Thr Thr Glu 
                245                 250                 255     


Ser Arg Cys Pro Thr Gln Gly Glu Pro Ser Leu Asn Glu Glu Gln Asp 
            260                 265                 270         


Lys Arg Phe Val Cys Lys His Ser Met Val Asp Arg Gly Trp Gly Asn 
        275                 280                 285             


Gly Cys Gly Leu Phe Gly Lys Gly Gly Ile Val Thr Cys Ala Met Phe 
    290                 295                 300                 


Thr Cys Lys Lys Asn Met Glu Gly Lys Ile Val Gln Pro Glu Asn Leu 
305                 310                 315                 320 


Glu Tyr Thr Ile Val Ile Thr Pro His Ser Gly Glu Glu His Ala Val 
                325                 330                 335     


Gly Asn Asp Thr Gly Lys His Gly Lys Glu Ile Lys Val Thr Pro Gln 
            340                 345                 350         


Ser Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met 
        355                 360                 365             


Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Val Leu Leu 
    370                 375                 380                 


Gln Met Glu Asn Lys Ala Trp Leu Val His Arg Gln Trp Phe Leu Asp 
385                 390                 395                 400 


Leu Pro Leu Pro Trp Leu Pro Gly Ala Asp Thr Gln Gly Ser Asn Trp 
                405                 410                 415     


Ile Gln Lys Glu Thr Leu Val Thr Phe Lys Asn Pro His Ala Lys Lys 
            420                 425                 430         


Gln Asp Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala 
        435                 440                 445             


Leu Thr Gly Ala Thr Glu Ile Gln Met Ser Ser Gly Asn Leu Leu Phe 
    450                 455                 460                 


Thr Gly His Leu Lys Cys Arg Leu Arg Met Asp Lys Leu Gln Leu Lys 
465                 470                 475                 480 


Gly Met Ser Tyr Ser Met Cys Thr Gly Lys Phe Lys Val Val Lys Glu 
                485                 490                 495     


Ile Ala Glu Thr Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu 
            500                 505                 510         


Gly Asp Gly Ser Pro Cys Lys Ile Pro Phe Glu Ile Met Asp Leu Glu 
        515                 520                 525             


Lys Arg His Val Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr 
    530                 535                 540                 


Glu Lys Asp Ser Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp 
545                 550                 555                 560 


Ser Tyr Ile Ile Ile Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp 
                565                 570                 575     


Phe Lys Lys Gly Ser Ser Ile Gly Gln Met Phe Glu Thr Thr Met Arg 
            580                 585                 590         


Gly Ala Lys Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly 
        595                 600                 605             


Ser Leu Gly Gly Val Phe Thr Ser Ile Gly Lys Ala Leu His Gln Val 
    610                 615                 620                 


Phe Gly Ala Ile Tyr Gly Ala Ala Phe Ser Gly Val Ser Trp Thr Met 
625                 630                 635                 640 


Lys Ile Leu Ile Gly Val Ile Ile Thr Trp Ile Gly Met Asn Ser Arg 
                645                 650                 655     


Ser Thr Ser Leu Ser Val Ser Leu Val Leu Val Gly Val Val Thr Leu 
            660                 665                 670         


Tyr Leu Gly Val Met Val Gln Ala 
        675                 680 


<210>  9
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DENV 3 prME

<400>  9
aacaaaagaa agaaaacttc actgtgcctg atgatgatgc tgccagccac tctggctttc       60

cacctgacca gccgagacgg agaaccacgg atgatcgtgg gcaagaacga gagggggaaa      120

agtctgctgt ttaagaccgc ttcaggcatt aatatgtgca cactgatcgc aatggatctg      180

ggggagatgt gcgacgatac cgtcacatac aagtgtcccc atattaccga ggtggaacct      240

gaggacatcg attgctggtg taacctgact agtacctggg tgacttatgg gacctgtaat      300

caggccggag agcaccggag agacaagaga tcagtcgccc tggctcctca tgtgggcatg      360

gggctggata caagaactca gacctggatg agcgcagagg gagcatggcg acaggtcgaa      420

aaagtggaga cttgggccct gcgacaccct ggattcacca ttctggccct gtttctggct      480

cattacatcg gcacatcact gactcagaag gtggtcatct tcattctgct gatgctggtg      540

acaccaagca tgactatgag atgcgtcgga gtgggcaaca gggactttgt cgaagggctg      600

tccggagcca cctgggtgga tgtggtcctg gagcacggcg gatgtgtgac cacaatggct      660

aagaacaagc caaccctgga cattgaactg cagaagaccg aggcaacaca gctggccaca      720

ctgaggaaac tgtgcatcga agggaagatt actaacatca ctaccgattc ccgctgtcca      780

acccagggag aggctgtgct gcccgaggaa caggaccaga actacgtctg caagcataca      840

tatgtggata gagggtgggg aaatggctgt gggctgttcg gaaaaggctc tctggtgacc      900

tgcgccaagt ttcagtgtct ggaacccatc gagggaaaag tggtccagta cgagaacctg      960

aagtatacag tcatcattac tgtgcacacc ggcgaccagc atcaggtcgg aaatgaaacc     1020

cagggcgtga cagccgagat tactccccag gcctccaccg tggaagctat cctgcctgag     1080

tatggcacac tggggctgga atgctctccc cgaactggcc tggacttcaa cgagatgatc     1140

ctgctgacaa tgaagaacaa ggcttggatg gtgcaccgcc agtggttctt tgatctgcca     1200

ctgccctgga cttccggcgc aacaactgaa acacctactt ggaaccggaa agagctgctg     1260

gtgaccttta agaatgcaca cgccaagaaa caggaagtgg tcgtgctggg atctcaggag     1320

ggcgctatgc atacagcact gactggcgcc accgaaattc agaactcagg aggcaccagc     1380

atcttcgctg ggcacctgaa atgcagactg aagatggaca aactggagct gaagggaatg     1440

tcttacgcca tgtgtaccaa tacatttgtc ctgaagaaag aagtgagtga gacccagcac     1500

gggacaatcc tgattaaggt ggaatataaa ggagaggacg ccccttgtaa aatcccattc     1560

agtaccgagg atgggcaggg aaaggcacat aacgggaggc tgattacagc caatcctgtc     1620

gtgactaaga aagaggaacc agtgaacatc gaagcagagc ccccttttgg cgaaagcaat     1680

atcgtgattg gcatcgggga taaggccctg aaaattaact ggtacaagaa agggagctcc     1740

atcggaaaaa tgttcgaggc tacagcacgc ggcgctaggc gaatggcaat tctgggcgac     1800

actgcctggg attttgggag cgtcggggga gtgctgaatt ccctgggaaa gatggtgcac     1860

cagatcttcg gcagcgctta taccgcactg ttttctggcg tcagttggat tatgaaaatt     1920

ggaatcggcg tgctgctgac ctggatcggg ctgaactcca agaatacatc tatgtccttt     1980

tcatgtattg ctattggaat tattactctg tatctgggag ccgtggtgca ggcc           2034


<210>  10
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV 3 prME

<400>  10

Asn Lys Arg Lys Lys Thr Ser Leu Cys Leu Met Met Met Leu Pro Ala 
1               5                   10                  15      


Thr Leu Ala Phe His Leu Thr Ser Arg Asp Gly Glu Pro Arg Met Ile 
            20                  25                  30          


Val Gly Lys Asn Glu Arg Gly Lys Ser Leu Leu Phe Lys Thr Ala Ser 
        35                  40                  45              


Gly Ile Asn Met Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys 
    50                  55                  60                  


Asp Asp Thr Val Thr Tyr Lys Cys Pro His Ile Thr Glu Val Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Thr Tyr 
                85                  90                  95      


Gly Thr Cys Asn Gln Ala Gly Glu His Arg Arg Asp Lys Arg Ser Val 
            100                 105                 110         


Ala Leu Ala Pro His Val Gly Met Gly Leu Asp Thr Arg Thr Gln Thr 
        115                 120                 125             


Trp Met Ser Ala Glu Gly Ala Trp Arg Gln Val Glu Lys Val Glu Thr 
    130                 135                 140                 


Trp Ala Leu Arg His Pro Gly Phe Thr Ile Leu Ala Leu Phe Leu Ala 
145                 150                 155                 160 


His Tyr Ile Gly Thr Ser Leu Thr Gln Lys Val Val Ile Phe Ile Leu 
                165                 170                 175     


Leu Met Leu Val Thr Pro Ser Met Thr Met Arg Cys Val Gly Val Gly 
            180                 185                 190         


Asn Arg Asp Phe Val Glu Gly Leu Ser Gly Ala Thr Trp Val Asp Val 
        195                 200                 205             


Val Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Lys Asn Lys Pro 
    210                 215                 220                 


Thr Leu Asp Ile Glu Leu Gln Lys Thr Glu Ala Thr Gln Leu Ala Thr 
225                 230                 235                 240 


Leu Arg Lys Leu Cys Ile Glu Gly Lys Ile Thr Asn Ile Thr Thr Asp 
                245                 250                 255     


Ser Arg Cys Pro Thr Gln Gly Glu Ala Val Leu Pro Glu Glu Gln Asp 
            260                 265                 270         


Gln Asn Tyr Val Cys Lys His Thr Tyr Val Asp Arg Gly Trp Gly Asn 
        275                 280                 285             


Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe 
    290                 295                 300                 


Gln Cys Leu Glu Pro Ile Glu Gly Lys Val Val Gln Tyr Glu Asn Leu 
305                 310                 315                 320 


Lys Tyr Thr Val Ile Ile Thr Val His Thr Gly Asp Gln His Gln Val 
                325                 330                 335     


Gly Asn Glu Thr Gln Gly Val Thr Ala Glu Ile Thr Pro Gln Ala Ser 
            340                 345                 350         


Thr Val Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu Glu Cys 
        355                 360                 365             


Ser Pro Arg Thr Gly Leu Asp Phe Asn Glu Met Ile Leu Leu Thr Met 
    370                 375                 380                 


Lys Asn Lys Ala Trp Met Val His Arg Gln Trp Phe Phe Asp Leu Pro 
385                 390                 395                 400 


Leu Pro Trp Thr Ser Gly Ala Thr Thr Glu Thr Pro Thr Trp Asn Arg 
                405                 410                 415     


Lys Glu Leu Leu Val Thr Phe Lys Asn Ala His Ala Lys Lys Gln Glu 
            420                 425                 430         


Val Val Val Leu Gly Ser Gln Glu Gly Ala Met His Thr Ala Leu Thr 
        435                 440                 445             


Gly Ala Thr Glu Ile Gln Asn Ser Gly Gly Thr Ser Ile Phe Ala Gly 
    450                 455                 460                 


His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Glu Leu Lys Gly Met 
465                 470                 475                 480 


Ser Tyr Ala Met Cys Thr Asn Thr Phe Val Leu Lys Lys Glu Val Ser 
                485                 490                 495     


Glu Thr Gln His Gly Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu 
            500                 505                 510         


Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys 
        515                 520                 525             


Ala His Asn Gly Arg Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys 
    530                 535                 540                 


Glu Glu Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn 
545                 550                 555                 560 


Ile Val Ile Gly Ile Gly Asp Lys Ala Leu Lys Ile Asn Trp Tyr Lys 
                565                 570                 575     


Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ala Thr Ala Arg Gly Ala 
            580                 585                 590         


Arg Arg Met Ala Ile Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val 
        595                 600                 605             


Gly Gly Val Leu Asn Ser Leu Gly Lys Met Val His Gln Ile Phe Gly 
    610                 615                 620                 


Ser Ala Tyr Thr Ala Leu Phe Ser Gly Val Ser Trp Ile Met Lys Ile 
625                 630                 635                 640 


Gly Ile Gly Val Leu Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr 
                645                 650                 655     


Ser Met Ser Phe Ser Cys Ile Ala Ile Gly Ile Ile Thr Leu Tyr Leu 
            660                 665                 670         


Gly Ala Val Val Gln Ala 
        675             


<210>  11
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DENV 4 prME

<400>  11
aacgggagaa aaaggtcaac tattactctg ctgtgcctga ttcccaccgt catggcattc       60

cacctgagca caagagacgg ggagccactg atgatcgtgg ccaaacatga acgggggaga      120

cccctgctgt ttaaaaccac agagggaatt aacaagtgta cactgatcgc catggacctg      180

ggcgagatgt gcgaagatac cgtcacatac aagtgtcctc tgctggtgaa caccgagcca      240

gaagacattg attgctggtg taatctgact tccacctggg tcatgtatgg aacatgcact      300

cagtctggcg agcggagaag ggaaaaacga tccgtggctc tgacccctca ctctgggatg      360

ggactggaga cccgggcaga aacatggatg agctccgagg gcgcctggaa gcatgctcag      420

agagtggaat cctggattct gaggaaccct gggttcgctc tgctggcagg cttcatggca      480

tacatgattg gccagactgg catccagcgc accgtcttct ttgtgctgat gatgctggtg      540

gccccaagtt atggaatgcg ctgcgtcggc gtggggaatc gagacttcgt cgagggcgtg      600

tcaggcgggg cttgggtcga tctggtgctg gaacacggag gctgtgtgac taccatggca      660

cagggcaagc ctactctgga ctttgagctg accaaaacaa ctgcaaagga agtggccctg      720

ctgcgcacct actgcattga ggcctccatt tctaacatca ccacagctac tcggtgtcca      780

acccagggag aaccctacct gaaagaggaa caggatcagc agtatatctg ccgacgagac      840

gtggtcgatc gaggatgggg caatgggtgt ggactgttcg gcaagggcgg cgtggtcact      900

tgcgccaagt tcagctgttc aggaaagatt accggcaacc tggtgcagat cgagaatctg      960

gaatacacag tggtcgtgac tgtccacaat ggcgacacac atgcagtggg gaacgatact     1020

tctaatcacg gcgtgaccgc cacaatcact cctagaagcc catccgtcga ggtgaagctg     1080

cccgactatg gcgagctgac actggattgc gaacctagga gtgggattga cttcaacgag     1140

atgatcctga tgaaaatgaa gaaaaagacc tggctggtgc ataagcagtg gtttctggac     1200

ctgccactgc catggacagc aggagctgat actagcgagg tgcactggaa ttataaggaa     1260

aggatggtca cattcaaagt gccacatgcc aagcgccagg atgtcactgt gctggggagt     1320

caggagggag ctatgcactc agcactggca ggagctaccg aagtggacag cggcgatggg     1380

aaccacatgt tcgccggaca tctgaaatgc aaggtgcgaa tggagaaact gcggattaag     1440

ggcatgtcct acactatgtg ttctggcaag ttcagcatcg acaaggagat ggccgaaacc     1500

cagcacggca ctaccgtcgt gaaagtgaag tatgagggag caggcgcccc ctgtaaggtc     1560

cctatcgaga ttcgggatgt gaacaaggaa aaggtcgtgg gcagaatcat ttctagtacc     1620

cctctggctg agaacaccaa ttctgtgaca aacatcgagc tggaaccccc tttcggggac     1680

tcttacatcg tcattggggt gggaaatagt gccctgacac tgcactggtt ccggaaaggc     1740

tcaagcattg ggaagatgtt tgagagcact tataggggcg ctaaacgcat ggcaatcctg     1800

ggagaaaccg catgggattt cggcagcgtg ggcgggctgt ttacatccct gggaaaggct     1860

gtccatcagg tgttcggctc agtctacaca actatgtttg gaggcgtgag ctggatgatc     1920

agaattctga tcgggtttct ggtgctgtgg atcggaacca actcaaggaa tacaagcatg     1980

gctatgactt gtattgccgt gggcggaatt acactgtttc tgggattcac tgtgcaggct     2040


<210>  12
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV 4 prME

<400>  12

Asn Gly Arg Lys Arg Ser Thr Ile Thr Leu Leu Cys Leu Ile Pro Thr 
1               5                   10                  15      


Val Met Ala Phe His Leu Ser Thr Arg Asp Gly Glu Pro Leu Met Ile 
            20                  25                  30          


Val Ala Lys His Glu Arg Gly Arg Pro Leu Leu Phe Lys Thr Thr Glu 
        35                  40                  45              


Gly Ile Asn Lys Cys Thr Leu Ile Ala Met Asp Leu Gly Glu Met Cys 
    50                  55                  60                  


Glu Asp Thr Val Thr Tyr Lys Cys Pro Leu Leu Val Asn Thr Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Asp Cys Trp Cys Asn Leu Thr Ser Thr Trp Val Met Tyr 
                85                  90                  95      


Gly Thr Cys Thr Gln Ser Gly Glu Arg Arg Arg Glu Lys Arg Ser Val 
            100                 105                 110         


Ala Leu Thr Pro His Ser Gly Met Gly Leu Glu Thr Arg Ala Glu Thr 
        115                 120                 125             


Trp Met Ser Ser Glu Gly Ala Trp Lys His Ala Gln Arg Val Glu Ser 
    130                 135                 140                 


Trp Ile Leu Arg Asn Pro Gly Phe Ala Leu Leu Ala Gly Phe Met Ala 
145                 150                 155                 160 


Tyr Met Ile Gly Gln Thr Gly Ile Gln Arg Thr Val Phe Phe Val Leu 
                165                 170                 175     


Met Met Leu Val Ala Pro Ser Tyr Gly Met Arg Cys Val Gly Val Gly 
            180                 185                 190         


Asn Arg Asp Phe Val Glu Gly Val Ser Gly Gly Ala Trp Val Asp Leu 
        195                 200                 205             


Val Leu Glu His Gly Gly Cys Val Thr Thr Met Ala Gln Gly Lys Pro 
    210                 215                 220                 


Thr Leu Asp Phe Glu Leu Thr Lys Thr Thr Ala Lys Glu Val Ala Leu 
225                 230                 235                 240 


Leu Arg Thr Tyr Cys Ile Glu Ala Ser Ile Ser Asn Ile Thr Thr Ala 
                245                 250                 255     


Thr Arg Cys Pro Thr Gln Gly Glu Pro Tyr Leu Lys Glu Glu Gln Asp 
            260                 265                 270         


Gln Gln Tyr Ile Cys Arg Arg Asp Val Val Asp Arg Gly Trp Gly Asn 
        275                 280                 285             


Gly Cys Gly Leu Phe Gly Lys Gly Gly Val Val Thr Cys Ala Lys Phe 
    290                 295                 300                 


Ser Cys Ser Gly Lys Ile Thr Gly Asn Leu Val Gln Ile Glu Asn Leu 
305                 310                 315                 320 


Glu Tyr Thr Val Val Val Thr Val His Asn Gly Asp Thr His Ala Val 
                325                 330                 335     


Gly Asn Asp Thr Ser Asn His Gly Val Thr Ala Thr Ile Thr Pro Arg 
            340                 345                 350         


Ser Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu 
        355                 360                 365             


Asp Cys Glu Pro Arg Ser Gly Ile Asp Phe Asn Glu Met Ile Leu Met 
    370                 375                 380                 


Lys Met Lys Lys Lys Thr Trp Leu Val His Lys Gln Trp Phe Leu Asp 
385                 390                 395                 400 


Leu Pro Leu Pro Trp Thr Ala Gly Ala Asp Thr Ser Glu Val His Trp 
                405                 410                 415     


Asn Tyr Lys Glu Arg Met Val Thr Phe Lys Val Pro His Ala Lys Arg 
            420                 425                 430         


Gln Asp Val Thr Val Leu Gly Ser Gln Glu Gly Ala Met His Ser Ala 
        435                 440                 445             


Leu Ala Gly Ala Thr Glu Val Asp Ser Gly Asp Gly Asn His Met Phe 
    450                 455                 460                 


Ala Gly His Leu Lys Cys Lys Val Arg Met Glu Lys Leu Arg Ile Lys 
465                 470                 475                 480 


Gly Met Ser Tyr Thr Met Cys Ser Gly Lys Phe Ser Ile Asp Lys Glu 
                485                 490                 495     


Met Ala Glu Thr Gln His Gly Thr Thr Val Val Lys Val Lys Tyr Glu 
            500                 505                 510         


Gly Ala Gly Ala Pro Cys Lys Val Pro Ile Glu Ile Arg Asp Val Asn 
        515                 520                 525             


Lys Glu Lys Val Val Gly Arg Ile Ile Ser Ser Thr Pro Leu Ala Glu 
    530                 535                 540                 


Asn Thr Asn Ser Val Thr Asn Ile Glu Leu Glu Pro Pro Phe Gly Asp 
545                 550                 555                 560 


Ser Tyr Ile Val Ile Gly Val Gly Asn Ser Ala Leu Thr Leu His Trp 
                565                 570                 575     


Phe Arg Lys Gly Ser Ser Ile Gly Lys Met Phe Glu Ser Thr Tyr Arg 
            580                 585                 590         


Gly Ala Lys Arg Met Ala Ile Leu Gly Glu Thr Ala Trp Asp Phe Gly 
        595                 600                 605             


Ser Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His Gln Val 
    610                 615                 620                 


Phe Gly Ser Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp Met Ile 
625                 630                 635                 640 


Arg Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn Ser Arg 
                645                 650                 655     


Asn Thr Ser Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile Thr Leu 
            660                 665                 670         


Phe Leu Gly Phe Thr Val Gln Ala 
        675                 680 


<210>  13
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika -prME

<400>  13
gggattattg gactgctgct gactactgcc atggcagcag agatcaccag gagaggcagc       60

gcctactata tgtacctgga ccggtctgat gccggcaagg ccatcagctt tgccaccaca      120

ctgggcgtga ataagtgcca cgtgcagatc atggacctgg gccacatgtg cgatgccacc      180

atgtcctacg agtgtccaat gctggacgag ggcgtggagc ccgacgatgt ggattgctgg      240

tgtaacacca catctacatg ggtggtgtat ggcacctgtc accacaagaa gggagaggca      300

cggcgcagca ggagagcagt gacactgccc tctcacagca ccaggaagct gcagacaaga      360

agccagacct ggctggagtc ccgggagtat acaaagcacc tgatcaaggt ggagaactgg      420

atctttcgca atccaggatt cgcactggtg gcagtggcaa tcgcatggct gctgggcagc      480

tccacctccc agaaagtgat ctacctggtc atgatcctgc tgatcgcccc tgcctattcc      540

atcaggtgca tcggcgtgtc taatagagac ttcgtggagg gcatgtctgg cggcacctgg      600

gtggatgtgg tgctggagca cggcggatgc gtgacagtga tggcccagga caagccaacc      660

gtggatatcg agctggtgac cacaaccgtg agcaacatgg ccgaggtgag gtcctactgc      720

tatgaggcct ccatctctga catggccagc gattccagat gtcccaccca gggcgaggcc      780

tacctggaca agcagtccga tacacagtac gtgtgcaagc ggaccctggt ggacagggga      840

tggggaaatg gatgtggcct gtttggcaag ggctctctgg tgacatgcgc caagttcacc      900

tgttctaaga agatgaccgg caagagcatc cagcccgaga acctggagta caggatcatg      960

ctgagcgtgc acggcagcca gcactccggc atgacagtga acgacatcgg ctatgagacc     1020

gatgagaata gggccaaggt ggaggtgaca cctaacagcc caagagccga ggccaccctg     1080

ggcggctttg gctccctggg actggactgc gagcctagaa caggcctgga cttctccgat     1140

ctgtactatc tgaccatgaa caataagcac tggctggtgc acaaggagtg gtttcacgac     1200

atcccactgc catggcacgc aggagcagat acaggaaccc cacactggaa caataaggag     1260

gccctggtgg agttcaagga tgcccacgcc aagcgccaga cagtggtggt gctgggcagc     1320

caggagggag cagtgcacac cgccctggca ggcgccctgg aggccgagat ggacggcgcc     1380

aagggcaagc tgttttccgg ccacctgaag tgccggctga agatggataa gctgcgcctg     1440

aagggcgtgt cttacagcct gtgcacagcc gccttcacct tcaccaaggt gcctgccgag     1500

accctgcacg gcacagtgac cgtggaggtg cagtatgccg gcacagacgg cccctgtaag     1560

atccctgtgc agatggccgt ggatatgcag acactgaccc ctgtgggccg gctgatcacc     1620

gcaaatccag tgatcacaga gtccaccgag aactctaaga tgatgctgga gctggaccct     1680

cccttcggcg acagctacat cgtgatcggc gtgggcgaca agaagatcac acaccactgg     1740

caccgctccg gctctacaat cggcaaggcc ttcgaggcaa ccgtgcgggg cgccaagagg     1800

atggccgtgc tgggcgacac cgcatgggat tttggctccg tgggcggcgt gttcaactct     1860

ctgggcaagg gcatccacca gatcttcggc gccgccttta agtctctgtt cggcggaatg     1920

tcttggttca gccagatcct gatcggcaca ctgctggtgt ggctgggcct gaacaccaag     1980

aatggcagca tctctctgac ttgtctggcc ctgggaggcg tgatgatttt cctgtccact     2040

gccgtgtctg cc                                                         2052


<210>  14
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika prME protein

<400>  14

Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr 
1               5                   10                  15      


Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly 
            20                  25                  30          


Lys Ala Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val 
        35                  40                  45              


Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu 
    50                  55                  60                  


Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp 
65                  70                  75                  80  


Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys 
                85                  90                  95      


Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His 
            100                 105                 110         


Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg 
        115                 120                 125             


Glu Tyr Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn 
    130                 135                 140                 


Pro Gly Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser 
145                 150                 155                 160 


Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala 
                165                 170                 175     


Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val 
            180                 185                 190         


Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly 
        195                 200                 205             


Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu 
    210                 215                 220                 


Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys 
225                 230                 235                 240 


Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr 
                245                 250                 255     


Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys 
            260                 265                 270         


Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe 
        275                 280                 285             


Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys 
    290                 295                 300                 


Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met 
305                 310                 315                 320 


Leu Ser Val His Gly Ser Gln His Ser Gly Met Thr Val Asn Asp Ile 
                325                 330                 335     


Gly Tyr Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn 
            340                 345                 350         


Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu 
        355                 360                 365             


Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu 
    370                 375                 380                 


Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp 
385                 390                 395                 400 


Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp 
                405                 410                 415     


Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg 
            420                 425                 430         


Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala 
        435                 440                 445             


Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Lys Leu 
    450                 455                 460                 


Phe Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu 
465                 470                 475                 480 


Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys 
                485                 490                 495     


Val Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr 
            500                 505                 510         


Ala Gly Thr Asp Gly Pro Cys Lys Ile Pro Val Gln Met Ala Val Asp 
        515                 520                 525             


Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val 
    530                 535                 540                 


Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro 
545                 550                 555                 560 


Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile 
                565                 570                 575     


Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu 
            580                 585                 590         


Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala 
        595                 600                 605             


Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly 
    610                 615                 620                 


Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met 
625                 630                 635                 640 


Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly 
                645                 650                 655     


Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly 
            660                 665                 670         


Gly Val Met Ile Phe Leu Ser Thr Ala Val Ser Ala 
        675                 680                 


<210>  15
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE prME protein

<400>  15

Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr 
1               5                   10                  15      


Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly 
            20                  25                  30          


Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile 
        35                  40                  45              


Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu 
    50                  55                  60                  


Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp 
65                  70                  75                  80  


Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys 
                85                  90                  95      


Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His 
            100                 105                 110         


Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg 
        115                 120                 125             


Glu Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn 
    130                 135                 140                 


Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser 
145                 150                 155                 160 


Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala 
                165                 170                 175     


Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val 
            180                 185                 190         


Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly 
        195                 200                 205             


Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu 
    210                 215                 220                 


Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys 
225                 230                 235                 240 


Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr 
                245                 250                 255     


Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys 
            260                 265                 270         


Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe 
        275                 280                 285             


Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys 
    290                 295                 300                 


Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met 
305                 310                 315                 320 


Leu Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Ile 
                325                 330                 335     


Gly His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr Pro Asn 
            340                 345                 350         


Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu 
        355                 360                 365             


Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu 
    370                 375                 380                 


Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp 
385                 390                 395                 400 


Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp 
                405                 410                 415     


Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg 
            420                 425                 430         


Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala 
        435                 440                 445             


Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu 
    450                 455                 460                 


Phe Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu 
465                 470                 475                 480 


Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys 
                485                 490                 495     


Val Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr 
            500                 505                 510         


Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp 
        515                 520                 525             


Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val 
    530                 535                 540                 


Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro 
545                 550                 555                 560 


Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys Lys Ile 
                565                 570                 575     


Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu 
            580                 585                 590         


Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala 
        595                 600                 605             


Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly Lys Gly 
    610                 615                 620                 


Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met 
625                 630                 635                 640 


Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp Leu Gly 
                645                 650                 655     


Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly 
            660                 665                 670         


Gly Val Met Ile Phe Leu Ser Thr Ala Val Ser Ala 
        675                 680                 


<210>  16
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika NS1

<400>  16
gtgggatgca gcgtggactt cagcaagaag gagacccgct gcggaacagg cgtgttcgtg       60

tacaacgacg tggaggcttg gagagaccgg tacaagtacc accccgatag ccctagaaga      120

ctggccgcag ccgtgaaaca ggcttgggaa gagggaattt gcggcatcag cagcgtgtcc      180

cggatggaga acatcatgtg gaagagcgtg gagggcgagc tgaacgctat cctggaggag      240

aacggcgtgc agctgacagt ggtcgtggga tcagtgaaga accccatgtg gagaggccct      300

cagaggctgc cagtgccagt gaacgaactg cctcacggtt ggaaggcttg gggcaagagc      360

tacttcgtga gggccgccaa gaccaacaac agcttcgtgg tggacggcga taccctcaag      420

gagtgtcctc tgaagcaccg ggcttggaac agcttcctgg tggaagacca cggctttggc      480

gtgttccaca caagcgtctg gctgaaggtc cgcgaagact acagcctgga gtgcgatcca      540

gcagtgatcg gcacagccgt gaagggaaaa gaggccgctc acagcgacct gggctattgg      600

atcgagagcg agaagaacga cacttggagg ctgaagcggg cccacctgat cgagatgaag      660

acttgcgagt ggcccaagag ccacactctg tggacagacg gcgtggaaga gagcgacctg      720

atcatcccta agagcctggc cggacctctg tctcatcaca acaccaggga gggctacaga      780

acccaggtga agggaccttg gcacagcgaa gagctggaga tccgcttcga ggagtgtcca      840

ggaaccaagg tgcacgtgga ggagacttgc ggaaccagag gccctagcct gagaagcaca      900

acagccagcg gacgcgtgat cgaggagtgg tgttgtaggg agtgcaccat gcctcctctg      960

agcttcaggg ccaaggacgg ttgttggtac ggcatggaga tcaggcccag aaaggagcca     1020

gagagcaacc tcgtgcggtc tatggtgaca gccggaagc                            1059


<210>  17
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika NS1 protein

<400>  17

Val Gly Cys Ser Val Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr 
1               5                   10                  15      


Gly Val Phe Val Tyr Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys 
            20                  25                  30          


Tyr His Pro Asp Ser Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala 
        35                  40                  45              


Trp Glu Glu Gly Ile Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn 
    50                  55                  60                  


Ile Met Trp Lys Ser Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu 
65                  70                  75                  80  


Asn Gly Val Gln Leu Thr Val Val Val Gly Ser Val Lys Asn Pro Met 
                85                  90                  95      


Trp Arg Gly Pro Gln Arg Leu Pro Val Pro Val Asn Glu Leu Pro His 
            100                 105                 110         


Gly Trp Lys Ala Trp Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr 
        115                 120                 125             


Asn Asn Ser Phe Val Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu 
    130                 135                 140                 


Lys His Arg Ala Trp Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly 
145                 150                 155                 160 


Val Phe His Thr Ser Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu 
                165                 170                 175     


Glu Cys Asp Pro Ala Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala 
            180                 185                 190         


Ala His Ser Asp Leu Gly Tyr Trp Ile Glu Ser Glu Lys Asn Asp Thr 
        195                 200                 205             


Trp Arg Leu Lys Arg Ala His Leu Ile Glu Met Lys Thr Cys Glu Trp 
    210                 215                 220                 


Pro Lys Ser His Thr Leu Trp Thr Asp Gly Val Glu Glu Ser Asp Leu 
225                 230                 235                 240 


Ile Ile Pro Lys Ser Leu Ala Gly Pro Leu Ser His His Asn Thr Arg 
                245                 250                 255     


Glu Gly Tyr Arg Thr Gln Val Lys Gly Pro Trp His Ser Glu Glu Leu 
            260                 265                 270         


Glu Ile Arg Phe Glu Glu Cys Pro Gly Thr Lys Val His Val Glu Glu 
        275                 280                 285             


Thr Cys Gly Thr Arg Gly Pro Ser Leu Arg Ser Thr Thr Ala Ser Gly 
    290                 295                 300                 


Arg Val Ile Glu Glu Trp Cys Cys Arg Glu Cys Thr Met Pro Pro Leu 
305                 310                 315                 320 


Ser Phe Arg Ala Lys Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro 
                325                 330                 335     


Arg Lys Glu Pro Glu Ser Asn Leu Val Arg Ser Met Val Thr Ala Gly 
            340                 345                 350         


Ser 
    


<210>  18
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika capsid

<400>  18
aagaacccca agaagaagag cggcggcttc aggatcgtga acatgctgaa gcggggcgtg       60

gctagagtga accctctggg aggcggactg aagagactgc cagcaggact gctcctggga      120

cacggaccta ttcgcatggt gctggccatc ctggctttcc tgaggttcac cgccatcaag      180

cccagcctgg gactgatcaa ccgctggggt tcagtcggca agaaggaggc catggagatc      240

atcaagaagt tcaagaagga cctggccgcc atgctgagga tcatcaacgc ccggaaggag      300

cggaagagaa gaggagccga caccagcatc ggcatcatcg gactgctgct gacaaccgcc      360

atggctgccg agatc                                                       375


<210>  19
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika capsid protein

<400>  19

Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met Leu 
1               5                   10                  15      


Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile 
        115                 120                 125 


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader

<400>  20

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


