                         SEQUENCE LISTING

<110>  Exelixis, Inc.
 
<120>  Compounds for the Treatment of Kinase-Dependent Disorders

<130>  224990/18-001-PC/443525

<140>  PCT/US2019/015289
<141>  2019-01-25

<150>  62/622,626
<151>  2018-01-26

<150>  62/622,629
<151>  2018-01-26

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Arg Gly Leu Pro Pro Leu Leu Val Val Leu Leu Gly Cys 
1               5                   10                  15      


Trp Ala Ser Val Ser Ala Gln Thr Asp Ala Thr Pro Ala Val Thr Thr 
            20                  25                  30          


Glu Gly Leu Asn Ser Thr Glu Ala Ala Leu Ala Thr Phe Gly Thr Phe 
        35                  40                  45              


Pro Ser Thr Arg Pro Pro Gly Thr Pro Arg Ala Pro Gly Pro Ser Ser 
    50                  55                  60                  


Gly Pro Arg Pro Thr Pro Val Thr Asp Val Ala Val Leu Cys Val Cys 
65                  70                  75                  80  


Asp Leu Ser Pro Ala Gln Cys Asp Ile Asn Cys Cys Cys Asp Pro Asp 
                85                  90                  95      


Cys Ser Ser Val Asp Phe Ser Val Phe Ser Ala Cys Ser Val Pro Val 
            100                 105                 110         


Val Thr Gly Asp Ser Gln Phe Cys Ser Gln Lys Ala Val Ile Tyr Ser 
        115                 120                 125             


Leu Asn Phe Thr Ala Asn Pro Pro Gln Arg Val Phe Glu Leu Val Asp 
    130                 135                 140                 


Gln Ile Asn Pro Ser Ile Phe Cys Ile His Ile Thr Asn Tyr Lys Pro 
145                 150                 155                 160 


Ala Leu Ser Phe Ile Asn Pro Glu Val Pro Asp Glu Asn Asn Phe Asp 
                165                 170                 175     


Thr Leu Met Lys Thr Ser Asp Gly Phe Thr Leu Asn Ala Glu Ser Tyr 
            180                 185                 190         


Val Ser Phe Thr Thr Lys Leu Asp Ile Pro Thr Ala Ala Lys Tyr Glu 
        195                 200                 205             


Tyr Gly Val Pro Leu Gln Thr Ser Asp Ser Phe Leu Arg Phe Pro Ser 
    210                 215                 220                 


Ser Leu Thr Ser Ser Leu Cys Thr Asp Asn Asn Pro Ala Ala Phe Leu 
225                 230                 235                 240 


Val Asn Gln Ala Val Lys Cys Thr Arg Lys Ile Asn Leu Glu Gln Cys 
                245                 250                 255     


Glu Glu Ile Glu Ala Leu Ser Met Ala Phe Tyr Ser Ser Pro Glu Ile 
            260                 265                 270         


Leu Arg Val Pro Asp Ser Arg Lys Lys Val Pro Ile Thr Val Gln Ser 
        275                 280                 285             


Ile Val Ile Gln Ser Leu Asn Lys Thr Leu Thr Arg Arg Glu Asp Thr 
    290                 295                 300                 


Asp Val Leu Gln Pro Thr Leu Val Asn Ala Gly His Phe Ser Leu Cys 
305                 310                 315                 320 


Val Asn Val Val Leu Glu Val Lys Tyr Ser Leu Thr Tyr Thr Asp Ala 
                325                 330                 335     


Gly Glu Val Thr Lys Ala Asp Leu Ser Phe Val Leu Gly Thr Val Ser 
            340                 345                 350         


Ser Val Val Val Pro Leu Gln Gln Lys Phe Glu Ile His Phe Leu Gln 
        355                 360                 365             


Glu Asn Thr Gln Pro Val Pro Leu Ser Gly Asn Pro Gly Tyr Val Val 
    370                 375                 380                 


Gly Leu Pro Leu Ala Ala Gly Phe Gln Pro His Lys Gly Ser Gly Ile 
385                 390                 395                 400 


Ile Gln Thr Thr Asn Arg Tyr Gly Gln Leu Thr Ile Leu His Ser Thr 
                405                 410                 415     


Thr Glu Gln Asp Cys Leu Ala Leu Glu Gly Val Arg Thr Pro Val Leu 
            420                 425                 430         


Phe Gly Tyr Thr Met Gln Ser Gly Cys Lys Leu Arg Leu Thr Gly Ala 
        435                 440                 445             


Leu Pro Cys Gln Leu Val Ala Gln Lys Val Lys Ser Leu Leu Trp Gly 
    450                 455                 460                 


Gln Gly Phe Pro Asp Tyr Val Ala Pro Phe Gly Asn Ser Gln Ala Gln 
465                 470                 475                 480 


Asp Met Leu Asp Trp Val Pro Ile His Phe Ile Thr Gln Ser Phe Asn 
                485                 490                 495     


Arg Lys Asp Ser Cys Gln Leu Pro Gly Ala Leu Val Ile Glu Val Lys 
            500                 505                 510         


Trp Thr Lys Tyr Gly Ser Leu Leu Asn Pro Gln Ala Lys Ile Val Asn 
        515                 520                 525             


Val Thr Ala Asn Leu Ile Ser Ser Ser Phe Pro Glu Ala Asn Ser Gly 
    530                 535                 540                 


Asn Glu Arg Thr Ile Leu Ile Ser Thr Ala Val Thr Phe Val Asp Val 
545                 550                 555                 560 


Ser Ala Pro Ala Glu Ala Gly Phe Arg Ala Pro Pro Ala Ile Asn Ala 
                565                 570                 575     


Arg Leu Pro Phe Asn Phe Phe Phe Pro Phe Val 
            580                 585         


<210>  2
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Phe Gln Pro Pro Ala Ala Leu Leu Leu Arg Leu Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ile Leu Arg Leu Leu Trp Gly Asp Leu Ala Phe Ile Pro Pro 
            20                  25                  30          


Phe Ile Arg Met Ser Gly Pro Ala Val Ser Ala Ser Leu Val Gly Asp 
        35                  40                  45              


Thr Glu Gly Val Thr Val Ser Leu Ala Val Leu Gln Asp Glu Ala Gly 
    50                  55                  60                  


Ile Leu Pro Ile Pro Thr Cys Gly Val Leu Asn Asn Glu Thr Glu Asp 
65                  70                  75                  80  


Trp Ser Val Thr Val Ile Pro Gly Ala Lys Val Leu Glu Val Thr Val 
                85                  90                  95      


Arg Trp Lys Arg Gly Leu Asp Trp Cys Ser Ser Asn Glu Thr Asp Ser 
            100                 105                 110         


Phe Ser Glu Ser Pro Cys Ile Leu Gln Thr Leu Leu Val Ser Ala Ser 
        115                 120                 125             


His Asn Ser Ser Cys Ser Ala His Leu Leu Ile Gln Val Glu Ile Tyr 
    130                 135                 140                 


Ala Asn Ser Ser Leu Thr His Asn Ala Ser Glu Asn Val Thr Val Ile 
145                 150                 155                 160 


Pro Asn Gln Val Tyr Gln Pro Leu Gly Pro Cys Pro Cys Asn Leu Thr 
                165                 170                 175     


Ala Gly Ala Cys Asp Val Arg Cys Cys Cys Asp Gln Glu Cys Ser Ser 
            180                 185                 190         


Asn Leu Thr Thr Leu Phe Arg Arg Ser Cys Phe Thr Gly Val Phe Gly 
        195                 200                 205             


Gly Asp Val Asn Pro Pro Phe Asp Gln Leu Cys Ser Ala Gly Thr Thr 
    210                 215                 220                 


Thr Arg Gly Val Pro Asp Trp Phe Pro Phe Leu Cys Val Gln Ser Pro 
225                 230                 235                 240 


Leu Ala Asn Thr Pro Phe Leu Gly Tyr Phe Tyr His Gly Ala Val Ser 
                245                 250                 255     


Pro Lys Gln Asp Ser Ser Phe Glu Val Tyr Val Asp Thr Asp Ala Lys 
            260                 265                 270         


Asp Phe Ala Asp Phe Gly Tyr Lys Gln Gly Asp Pro Ile Met Thr Val 
        275                 280                 285             


Lys Lys Ala Tyr Phe Thr Ile Pro Gln Val Ser Leu Ala Gly Gln Cys 
    290                 295                 300                 


Met Gln Asn Ala Pro Val Ala Phe Leu His Asn Phe Asp Val Lys Cys 
305                 310                 315                 320 


Val Thr Asn Leu Glu Leu Tyr Gln Glu Arg Asp Gly Ile Ile Asn Ala 
                325                 330                 335     


Lys Ile Lys Asn Val Ala Leu Gly Gly Ile Val Thr Pro Lys Val Ile 
            340                 345                 350         


Tyr Glu Glu Ala Thr Asp Leu Asp Lys Phe Ile Thr Asn Thr Glu Thr 
        355                 360                 365             


Pro Leu Asn Asn Gly Ser Thr Pro Arg Ile Val Asn Val Glu Glu His 
    370                 375                 380                 


Tyr Ile Phe Lys Trp Asn Asn Asn Thr Ile Ser Glu Ile Asn Val Lys 
385                 390                 395                 400 


Ile Phe Arg Ala Glu Ile Asn Ala His Gln Lys Gly Ile Met Thr Gln 
                405                 410                 415     


Arg Phe Val Val Lys Phe Leu Ser Tyr Asn Ser Gly Asn Glu Glu Glu 
            420                 425                 430         


Leu Ser Gly Asn Pro Gly Tyr Gln Leu Gly Lys Pro Val Arg Ala Leu 
        435                 440                 445             


Asn Ile Asn Arg Met Asn Asn Val Thr Thr Leu His Leu Trp Gln Ser 
    450                 455                 460                 


Ala Gly Arg Gly Leu Cys Thr Ser Ala Thr Phe Lys Pro Ile Leu Phe 
465                 470                 475                 480 


Gly Glu Asn Val Leu Ser Gly Cys Leu Leu Glu Val Gly Ile Asn Glu 
                485                 490                 495     


Asn Cys Thr Gln Leu Arg Glu Asn Ala Val Glu Arg Leu Asp Ser Leu 
            500                 505                 510         


Ile Gln Ala Thr His Val Ala Met Arg Gly Asn Ser Asp Tyr Ala Asp 
        515                 520                 525             


Leu Ser Asp Gly Trp Leu Glu Ile Ile Arg Val Asp Ala Pro Asp Pro 
    530                 535                 540                 


Gly Ala Asp Pro Leu Ala Ser Ser Val Asn Gly Met Cys Leu Asp Ile 
545                 550                 555                 560 


Pro Ala His Leu Ser Ile Arg Ile Leu Ile Ser Asp Ala Gly Ala Val 
                565                 570                 575     


Glu Gly Ile Thr Gln Gln Glu Ile Leu Gly Val Glu Thr Arg Phe Ser 
            580                 585                 590         


Ser Val Asn Trp Gln Tyr Gln Cys Gly Leu Thr Cys Glu His Lys Ala 
        595                 600                 605             


Asp Leu Leu Pro Ile Ser Ala Ser Val Gln Phe Ile Lys Ile Pro Ala 
    610                 615                 620                 


Gln Leu Pro His Pro Leu Thr Arg Phe Gln Ile Asn Tyr Thr Glu Tyr 
625                 630                 635                 640 


Asp Cys Asn Arg Asn Glu Val Cys Trp Pro Gln Leu Leu Tyr Pro Trp 
                645                 650                 655     


Thr Gln Tyr Tyr Gln Gly Glu Leu His Ser Gln Cys Val Ala Lys Gly 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Thr Leu Ala Leu Phe Leu Ser Asn Pro 
        675                 680                 685             


Trp Thr Arg Ile Cys Lys Ala Tyr Ser 
    690                 695         


<210>  3
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Thr Pro Gln Leu Ala Leu Leu Gln Val Phe Phe Leu Val Phe 
1               5                   10                  15      


Pro Asp Gly Val Arg Pro Gln Pro Ser Ser Ser Pro Ser Gly Ala Val 
            20                  25                  30          


Pro Thr Ser Leu Glu Leu Gln Arg Gly Thr Asp Gly Gly Thr Leu Gln 
        35                  40                  45              


Ser Pro Ser Glu Ala Thr Ala Thr Arg Pro Ala Val Pro Gly Leu Pro 
    50                  55                  60                  


Thr Val Val Pro Thr Leu Val Thr Pro Ser Ala Pro Gly Asn Arg Thr 
65                  70                  75                  80  


Val Asp Leu Phe Pro Val Leu Pro Ile Cys Val Cys Asp Leu Thr Pro 
                85                  90                  95      


Gly Ala Cys Asp Ile Asn Cys Cys Cys Asp Arg Asp Cys Tyr Leu Leu 
            100                 105                 110         


His Pro Arg Thr Val Phe Ser Phe Cys Leu Pro Gly Ser Val Arg Ser 
        115                 120                 125             


Ser Ser Trp Val Cys Val Asp Asn Ser Val Ile Phe Arg Ser Asn Ser 
    130                 135                 140                 


Pro Phe Pro Ser Arg Val Phe Met Asp Ser Asn Gly Ile Arg Gln Phe 
145                 150                 155                 160 


Cys Val His Val Asn Asn Ser Asn Leu Asn Tyr Phe Gln Lys Leu Gln 
                165                 170                 175     


Lys Val Asn Ala Thr Asn Phe Gln Ala Leu Ala Ala Glu Phe Gly Gly 
            180                 185                 190         


Glu Ser Phe Thr Ser Thr Phe Gln Thr Gln Ser Pro Pro Ser Phe Tyr 
        195                 200                 205             


Arg Ala Gly Asp Pro Ile Leu Thr Tyr Phe Pro Lys Trp Ser Val Ile 
    210                 215                 220                 


Ser Leu Leu Arg Gln Pro Ala Gly Val Gly Ala Gly Gly Leu Cys Ala 
225                 230                 235                 240 


Glu Ser Asn Pro Ala Gly Phe Leu Glu Ser Lys Ser Thr Thr Cys Thr 
                245                 250                 255     


Arg Phe Phe Lys Asn Leu Ala Ser Ser Cys Thr Leu Asp Ser Ala Leu 
            260                 265                 270         


Asn Ala Ala Ser Tyr Tyr Asn Phe Thr Val Leu Lys Val Pro Arg Ser 
        275                 280                 285             


Met Thr Asp Pro Gln Asn Met Glu Phe Gln Val Pro Val Ile Leu Thr 
    290                 295                 300                 


Ser Gln Ala Asn Ala Pro Leu Leu Ala Gly Asn Thr Cys Gln Asn Val 
305                 310                 315                 320 


Val Ser Gln Val Thr Tyr Glu Ile Glu Thr Asn Gly Thr Phe Gly Ile 
                325                 330                 335     


Gln Lys Val Ser Val Ser Leu Gly Gln Thr Asn Leu Thr Val Glu Pro 
            340                 345                 350         


Gly Ala Ser Leu Gln Gln His Phe Ile Leu Arg Phe Arg Ala Phe Gln 
        355                 360                 365             


Gln Ser Thr Ala Ala Ser Leu Thr Ser Pro Arg Ser Gly Asn Pro Gly 
    370                 375                 380                 


Tyr Ile Val Gly Lys Pro Leu Leu Ala Leu Thr Asp Asp Ile Ser Tyr 
385                 390                 395                 400 


Ser Met Thr Leu Leu Gln Ser Gln Gly Asn Gly Ser Cys Ser Val Lys 
                405                 410                 415     


Arg His Glu Val Gln Phe Gly Val Asn Ala Ile Ser Gly Cys Lys Leu 
            420                 425                 430         


Arg Leu Lys Lys Ala Asp Cys Ser His Leu Gln Gln Glu Ile Tyr Gln 
        435                 440                 445             


Thr Leu His Gly Arg Pro Arg Pro Glu Tyr Val Ala Ile Phe Gly Asn 
    450                 455                 460                 


Ala Asp Pro Ala Gln Lys Gly Gly Trp Thr Arg Ile Leu Asn Arg His 
465                 470                 475                 480 


Cys Ser Ile Ser Ala Ile Asn Cys Thr Ser Cys Cys Leu Ile Pro Val 
                485                 490                 495     


Ser Leu Glu Ile Gln Val Leu Trp Ala Tyr Val Gly Leu Leu Ser Asn 
            500                 505                 510         


Pro Gln Ala His Val Ser Gly Val Arg Phe Leu Tyr Gln Cys Gln Ser 
        515                 520                 525             


Ile Gln Asp Ser Gln Gln Val Thr Glu Val Ser Leu Thr Thr Leu Val 
    530                 535                 540                 


Asn Phe Val Asp Ile Thr Gln Lys Pro Gln Pro Pro Arg Gly Gln Pro 
545                 550                 555                 560 


Lys Met Asp Trp Lys Trp Pro Phe Asp Phe Phe Pro Phe Lys Val Ala 
                565                 570                 575     


Phe Ser Arg Gly Val Phe Ser Gln Lys Cys Ser Val Ser Pro Ile Leu 
            580                 585                 590         


Ile Leu Cys Leu Leu Leu Leu Gly Val Leu Asn Leu Glu Thr Met 
        595                 600                 605         


<210>  4
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Pro Gly Pro Val Ile Pro Glu Val Pro Phe Glu Pro Ser 
1               5                   10                  15      


Lys Pro Pro Val Ile Glu Gly Leu Ser Pro Thr Val Tyr Arg Asn Pro 
            20                  25                  30          


Glu Ser Phe Lys Glu Lys Phe Val Arg Lys Thr Arg Glu Asn Pro Val 
        35                  40                  45              


Val Pro Ile Gly Cys Leu Ala Thr Ala Ala Ala Leu Thr Tyr Gly Leu 
    50                  55                  60                  


Tyr Ser Phe His Arg Gly Asn Ser Gln Arg Ser Gln Leu Met Met Arg 
65                  70                  75                  80  


Thr Arg Ile Ala Ala Gln Gly Phe Thr Val Ala Ala Ile Leu Leu Gly 
                85                  90                  95      


Leu Ala Val Thr Ala Met Lys Ser Arg Pro 
            100                 105     


<210>  5
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Thr Leu Gly Phe Val Thr Pro Glu Ala Pro Phe Glu Ser Ser 
1               5                   10                  15      


Lys Pro Pro Ile Phe Glu Gly Leu Ser Pro Thr Val Tyr Ser Asn Pro 
            20                  25                  30          


Glu Gly Phe Lys Glu Lys Phe Leu Arg Lys Thr Arg Glu Asn Pro Val 
        35                  40                  45              


Val Pro Ile Gly Phe Leu Cys Thr Ala Ala Val Leu Thr Asn Gly Leu 
    50                  55                  60                  


Tyr Cys Phe His Gln Gly Asn Ser Gln Cys Ser Arg Leu Met Met His 
65                  70                  75                  80  


Thr Gln Ile Ala Ala Gln Gly Phe Thr Ile Ala Ala Ile Leu Leu Gly 
                85                  90                  95      


Leu Ala Ala Thr Ala Met Lys Ser Pro Pro 
            100                 105     


<210>  6
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Cys Ser Ala Gly Glu Leu Leu Arg Gly Gly Asp Gly Gly Glu Arg 
1               5                   10                  15      


Asp Glu Asp Gly Asp Ala Leu Ala Glu Arg Glu Ala Ala Gly Thr Gly 
            20                  25                  30          


Trp Asp Pro Gly Ala Ser Pro Arg Arg Arg Gly Gln Arg Pro Lys Glu 
        35                  40                  45              


Ser Glu Gln Asp Val Glu Asp Ser Gln Asn His Thr Gly Glu Pro Val 
    50                  55                  60                  


Gly Asp Asp Tyr Lys Lys Met Gly Thr Leu Phe Gly Glu Leu Asn Lys 
65                  70                  75                  80  


Asn Leu Ile Asn Met Gly Phe Thr Arg Met Tyr Phe Gly Glu Arg Ile 
                85                  90                  95      


Val Glu Pro Val Ile Val Ile Phe Phe Trp Val Met Leu Trp Phe Leu 
            100                 105                 110         


Gly Leu Gln Ala Leu Gly Leu Val Ala Val Leu Cys Leu Val Ile Ile 
        115                 120                 125             


Tyr Val Gln Gln 
    130         


<210>  7
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Arg Ser Pro Gly Glu Gly Pro Ser Pro Ser Pro Met Asp Gln 
1               5                   10                  15      


Pro Ser Ala Pro Ser Asp Pro Thr Asp Gln Pro Pro Ala Ala His Ala 
            20                  25                  30          


Lys Pro Asp Pro Gly Ser Gly Gly Gln Pro Ala Gly Pro Gly Ala Ala 
        35                  40                  45              


Gly Glu Ala Leu Ala Val Leu Thr Ser Phe Gly Arg Arg Leu Leu Val 
    50                  55                  60                  


Leu Ile Pro Val Tyr Leu Ala Gly Ala Val Gly Leu Ser Val Gly Phe 
65                  70                  75                  80  


Val Leu Phe Gly Leu Ala Leu Tyr Leu Gly Trp Arg Arg Val Arg Asp 
                85                  90                  95      


Glu Lys Glu Arg Ser Leu Arg Ala Ala Arg Gln Leu Leu Asp Asp Glu 
            100                 105                 110         


Glu Gln Leu Thr Ala Lys Thr Leu Tyr Met Ser His Arg Glu Leu Pro 
        115                 120                 125             


Ala Trp Val Ser Phe Pro Asp Val Glu Lys Ala Glu Trp Leu Asn Lys 
    130                 135                 140                 


Ile Val Ala Gln Val Trp Pro Phe Leu Gly Gln Tyr Met Glu Lys Leu 
145                 150                 155                 160 


Leu Ala Glu Thr Val Ala Pro Ala Val Arg Gly Ser Asn Pro His Leu 
                165                 170                 175     


Gln Thr Phe Thr Phe Thr Arg Val Glu Leu Gly Glu Lys Pro Leu Arg 
            180                 185                 190         


Ile Ile Gly Val Lys Val His Pro Gly Gln Arg Lys Glu Gln Ile Leu 
        195                 200                 205             


Leu Asp Leu Asn Ile Ser Tyr Val Gly Asp Val Gln Ile Asp Val Glu 
    210                 215                 220                 


Val Lys Lys Tyr Phe Cys Lys Ala Gly Val Lys Gly Met Gln Leu His 
225                 230                 235                 240 


Gly Val Leu Arg Val Ile Leu Glu Pro Leu Ile Gly Asp Leu Pro Phe 
                245                 250                 255     


Val Gly Ala Val Ser Met Phe Phe Ile Arg Arg Pro Thr Leu Asp Ile 
            260                 265                 270         


Asn Trp Thr Gly Met Thr Asn Leu Leu Asp Ile Pro Gly Leu Ser Ser 
        275                 280                 285             


Leu Ser Asp Thr Met Ile Met Asp Ser Ile Ala Ala Phe Leu Val Leu 
    290                 295                 300                 


Pro Asn Arg Leu Leu Val Pro Leu Val Pro Asp Leu Gln Asp Val Ala 
305                 310                 315                 320 


Gln Leu Arg Ser Pro Leu Pro Arg Gly Ile Ile Arg Ile His Leu Leu 
                325                 330                 335     


Ala Ala Arg Gly Leu Ser Ser Lys Asp Lys Tyr Val Lys Gly Leu Ile 
            340                 345                 350         


Glu Gly Lys Ser Asp Pro Tyr Ala Leu Val Arg Leu Gly Thr Gln Thr 
        355                 360                 365             


Phe Cys Ser Arg Val Ile Asp Glu Glu Leu Asn Pro Gln Trp Gly Glu 
    370                 375                 380                 


Thr Tyr Glu Val Met Val His Glu Val Pro Gly Gln Glu Ile Glu Val 
385                 390                 395                 400 


Glu Val Phe Asp Lys Asp Pro Asp Lys Asp Asp Phe Leu Gly Arg Met 
                405                 410                 415     


Lys Leu Asp Val Gly Lys Val Leu Gln Ala Ser Val Leu Asp Asp Trp 
            420                 425                 430         


Phe Pro Leu Gln Gly Gly Gln Gly Gln Val His Leu Arg Leu Glu Trp 
        435                 440                 445             


Leu Ser Leu Leu Ser Asp Ala Glu Lys Leu Glu Gln Val Leu Gln Trp 
    450                 455                 460                 


Asn Trp Gly Val Ser Ser Arg Pro Asp Pro Pro Ser Ala Ala Ile Leu 
465                 470                 475                 480 


Val Val Tyr Leu Asp Arg Ala Gln Asp Leu Pro Leu Lys Lys Gly Asn 
                485                 490                 495     


Lys Glu Pro Asn Pro Met Val Gln Leu Ser Ile Gln Asp Val Thr Gln 
            500                 505                 510         


Glu Ser Lys Ala Val Tyr Ser Thr Asn Cys Pro Val Trp Glu Glu Ala 
        515                 520                 525             


Phe Arg Phe Phe Leu Gln Asp Pro Gln Ser Gln Glu Leu Asp Val Gln 
    530                 535                 540                 


Val Lys Asp Asp Ser Arg Ala Leu Thr Leu Gly Ala Leu Thr Leu Pro 
545                 550                 555                 560 


Leu Ala Arg Leu Leu Thr Ala Pro Glu Leu Ile Leu Asp Gln Trp Phe 
                565                 570                 575     


Gln Leu Ser Ser Ser Gly Pro Asn Ser Arg Leu Tyr Met Lys Leu Val 
            580                 585                 590         


Met Arg Ile Leu Tyr Leu Asp Ser Ser Glu Ile Cys Phe Pro Thr Val 
        595                 600                 605             


Pro Gly Cys Pro Gly Ala Trp Asp Val Asp Ser Glu Asn Pro Gln Arg 
    610                 615                 620                 


Gly Ser Ser Val Asp Ala Pro Pro Arg Pro Cys His Thr Thr Pro Asp 
625                 630                 635                 640 


Ser Gln Phe Gly Thr Glu His Val Leu Arg Ile His Val Leu Glu Ala 
                645                 650                 655     


Gln Asp Leu Ile Ala Lys Asp Arg Phe Leu Gly Gly Leu Val Lys Gly 
            660                 665                 670         


Lys Ser Asp Pro Tyr Val Lys Leu Lys Leu Ala Gly Arg Ser Phe Arg 
        675                 680                 685             


Ser His Val Val Arg Glu Asp Leu Asn Pro Arg Trp Asn Glu Val Phe 
    690                 695                 700                 


Glu Val Ile Val Thr Ser Val Pro Gly Gln Glu Leu Glu Val Glu Val 
705                 710                 715                 720 


Phe Asp Lys Asp Leu Asp Lys Asp Asp Phe Leu Gly Arg Cys Lys Val 
                725                 730                 735     


Arg Leu Thr Thr Val Leu Asn Ser Gly Phe Leu Asp Glu Trp Leu Thr 
            740                 745                 750         


Leu Glu Asp Val Pro Ser Gly Arg Leu His Leu Arg Leu Glu Arg Leu 
        755                 760                 765             


Thr Pro Arg Pro Thr Ala Ala Glu Leu Glu Glu Val Leu Gln Val Asn 
    770                 775                 780                 


Ser Leu Ile Gln Thr Gln Lys Ser Ala Glu Leu Ala Ala Ala Leu Leu 
785                 790                 795                 800 


Ser Ile Tyr Met Glu Arg Ala Glu Asp Leu Pro Leu Arg Lys Gly Thr 
                805                 810                 815     


Lys His Leu Ser Pro Tyr Ala Thr Leu Thr Val Gly Asp Ser Ser His 
            820                 825                 830         


Lys Thr Lys Thr Ile Ser Gln Thr Ser Ala Pro Val Trp Asp Glu Ser 
        835                 840                 845             


Ala Ser Phe Leu Ile Arg Lys Pro His Thr Glu Ser Leu Glu Leu Gln 
    850                 855                 860                 


Val Arg Gly Glu Gly Thr Gly Val Leu Gly Ser Leu Ser Leu Pro Leu 
865                 870                 875                 880 


Ser Glu Leu Leu Val Ala Asp Gln Leu Cys Leu Asp Arg Trp Phe Thr 
                885                 890                 895     


Leu Ser Ser Gly Gln Gly Gln Val Leu Leu Arg Ala Gln Leu Gly Ile 
            900                 905                 910         


Leu Val Ser Gln His Ser Gly Val Glu Ala His Ser His Ser Tyr Ser 
        915                 920                 925             


His Ser Ser Ser Ser Leu Ser Glu Glu Pro Glu Leu Ser Gly Gly Pro 
    930                 935                 940                 


Pro His Ile Thr Ser Ser Ala Pro Glu Leu Arg Gln Arg Leu Thr His 
945                 950                 955                 960 


Val Asp Ser Pro Leu Glu Ala Pro Ala Gly Pro Leu Gly Gln Val Lys 
                965                 970                 975     


Leu Thr Leu Trp Tyr Tyr Ser Glu Glu Arg Lys Leu Val Ser Ile Val 
            980                 985                 990         


His Gly Cys Arg Ser Leu Arg Gln  Asn Gly Arg Asp Pro  Pro Asp Pro 
        995                 1000                 1005             


Tyr Val  Ser Leu Leu Leu Leu  Pro Asp Lys Asn Arg  Gly Thr Lys 
    1010                 1015                 1020             


Arg Arg  Thr Ser Gln Lys Lys  Arg Thr Leu Ser Pro  Glu Phe Asn 
    1025                 1030                 1035             


Glu Arg  Phe Glu Trp Glu Leu  Pro Leu Asp Glu Ala  Gln Arg Arg 
    1040                 1045                 1050             


Lys Leu  Asp Val Ser Val Lys  Ser Asn Ser Ser Phe  Met Ser Arg 
    1055                 1060                 1065             


Glu Arg  Glu Leu Leu Gly Lys  Val Gln Leu Asp Leu  Ala Glu Thr 
    1070                 1075                 1080             


Asp Leu  Ser Gln Gly Val Ala  Arg Trp Tyr Asp Leu  Met Asp Asn 
    1085                 1090                 1095             


Lys Asp  Lys Gly Ser Ser 
    1100                 


<210>  8
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu 
        35                  40                  45              


Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr 
    50                  55                  60                  


Gly Glu Lys Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly 
65                  70                  75                  80  


Arg His Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp 
                85                  90                  95      


Ser Gly Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro 
            100                 105                 110         


Cys Glu Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln 
        115                 120                 125             


Val Ser Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala 
    130                 135                 140                 


Gly Val Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu 
145                 150                 155                 160 


Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr 
                165                 170                 175     


Leu Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr 
            180                 185                 190         


Leu Ala Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu 
        195                 200                 205             


Glu Lys Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr 
    210                 215                 220                 


Phe Asn Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu 
225                 230                 235                 240 


Asp Cys Val Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys 
                245                 250                 255     


His Thr Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
            260                 265                 270     


<210>  9
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Phe Lys Cys Trp Ser Val Val Leu Val Leu Gly Phe Ile Phe Leu 
1               5                   10                  15      


Glu Ser Glu Gly Arg Pro Thr Lys Glu Gly Gly Tyr Gly Leu Lys Ser 
            20                  25                  30          


Tyr Gln Pro Leu Met Arg Leu Arg His Lys Gln Glu Lys Asn Gln Glu 
        35                  40                  45              


Ser Ser Arg Val Lys Gly Phe Met Ile Gln Asp Gly Pro Phe Gly Ser 
    50                  55                  60                  


Cys Glu Asn Lys Tyr Cys Gly Leu Gly Arg His Cys Val Thr Ser Arg 
65                  70                  75                  80  


Glu Thr Gly Gln Ala Glu Cys Ala Cys Met Asp Leu Cys Lys Arg His 
                85                  90                  95      


Tyr Lys Pro Val Cys Gly Ser Asp Gly Glu Phe Tyr Glu Asn His Cys 
            100                 105                 110         


Glu Val His Arg Ala Ala Cys Leu Lys Lys Gln Lys Ile Thr Ile Val 
        115                 120                 125             


His Asn Glu Asp Cys Phe Phe Lys Gly Asp Lys Cys Lys Thr Thr Glu 
    130                 135                 140                 


Tyr Ser Lys Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys Tyr 
145                 150                 155                 160 


Ile Met Gln Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg Lys 
                165                 170                 175     


Lys Leu Leu Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser Asn 
            180                 185                 190         


Gly Leu Val Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu Glu 
        195                 200                 205             


Leu Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys Tyr 
    210                 215                 220                 


Asp Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr Arg 
225                 230                 235                 240 


Ala Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu Ser 
                245                 250                 255     


Ile Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala Ile 
            260                 265                 270         


Gln Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile Ile 
        275                 280                 285             


Leu Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp Gly 
    290                 295                 300                 


Ser Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr Thr 
305                 310                 315                 320 


Cys Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe Gln 
                325                 330                 335     


Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Arg 
            340                 345                 350         


Glu Pro Gly Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro 
        355                 360                 365             


Lys Pro Gln Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro Lys 
    370                 375                 380                 


Leu Ser Lys Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His Ile 
385                 390                 395                 400 


Ser Asn Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys 
                405                 410                 415     


Asn Glu Ala Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu Asp 
            420                 425                 430         


Ser Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu 
        435                 440                 445             


Gly Ile Gly Asn Met Phe Tyr Val Phe Tyr Glu Asp Gly Ile Lys Val 
    450                 455                 460                 


Ile Gln Pro Ile Glu Cys Glu Phe Gln Arg His Ile Lys Pro Ser Glu 
465                 470                 475                 480 


Lys Leu Leu Gly Phe Gln Asp Glu Val Cys Pro Lys Ala Glu Gly Asp 
                485                 490                 495     


Glu Val Gln Arg Cys Val Trp Ala Ser Ala Val Asn Val Lys Asp Lys 
            500                 505                 510         


Phe Ile Tyr Val Ala Gln Pro Thr Leu Asp Arg Val Leu Ile Val Asp 
        515                 520                 525             


Val Gln Ser Gln Lys Val Val Gln Ala Val Ser Thr Asp Pro Val Pro 
    530                 535                 540                 


Val Lys Leu His Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser 
545                 550                 555                 560 


Trp Gly Thr Leu Glu Lys Thr Ser Pro Thr Leu Gln Val Ile Thr Leu 
                565                 570                 575     


Ala Ser Gly Asn Val Pro His His Thr Ile His Thr Gln Pro Val Gly 
            580                 585                 590         


Lys Gln Phe Asp Arg Val Asp Asp Phe Phe Ile Pro Thr Thr Thr Leu 
        595                 600                 605             


Ile Ile Thr His Met Arg Phe Gly Phe Ile Leu His Lys Asp Glu Ala 
    610                 615                 620                 


Ala Leu Gln Lys Ile Asp Leu Glu Thr Met Ser Tyr Ile Lys Thr Ile 
625                 630                 635                 640 


Asn Leu Lys Asp Tyr Lys Cys Val Pro Gln Ser Leu Ala Tyr Thr His 
                645                 650                 655     


Leu Gly Gly Tyr Tyr Phe Ile Gly Cys Lys Pro Asp Ser Thr Gly Ala 
            660                 665                 670         


Val Ser Pro Gln Val Met Val Asp Gly Val Thr Asp Ser Val Ile Gly 
        675                 680                 685             


Phe Asn Ser Asp Val Thr Gly Thr Pro Tyr Val Ser Pro Asp Gly His 
    690                 695                 700                 


Tyr Leu Val Ser Ile Asn Asp Val Lys Gly Leu Val Arg Val Gln Tyr 
705                 710                 715                 720 


Ile Thr Ile Arg Gly Glu Ile Gln Glu Ala Phe Asp Ile Tyr Thr Asn 
                725                 730                 735     


Leu His Ile Ser Asp Leu Ala Phe Gln Pro Ser Phe Thr Glu Ala His 
            740                 745                 750         


Gln Tyr Asn Ile Tyr Gly Ser Ser Ser Thr Gln Thr Asp Val Leu Phe 
        755                 760                 765             


Val Glu Leu Ser Ser Gly Lys Val Lys Met Ile Lys Ser Leu Lys Glu 
    770                 775                 780                 


Pro Leu Lys Ala Glu Glu Trp Pro Trp Asn Arg Lys Asn Arg Gln Ile 
785                 790                 795                 800 


Gln Asp Ser Gly Leu Phe Gly Gln Tyr Leu Met Thr Pro Ser Lys Asp 
                805                 810                 815     


Ser Leu Phe Ile Leu Asp Gly Arg Leu Asn Lys Leu Asn Cys Glu Ile 
            820                 825                 830         


Thr Glu Val Glu Lys Gly Asn Thr Val Ile Trp Val Gly Asp Ala 
        835                 840                 845         


<210>  10
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Arg Leu Gly Ala Leu Gly Gly Ala Arg Ala Gly Leu Gly Leu 
1               5                   10                  15      


Leu Leu Gly Thr Ala Ala Gly Leu Gly Phe Leu Cys Leu Leu Tyr Ser 
            20                  25                  30          


Gln Arg Trp Lys Arg Thr Gln Arg His Gly Arg Ser Gln Ser Leu Pro 
        35                  40                  45              


Asn Ser Leu Asp Tyr Thr Gln Thr Ser Asp Pro Gly Arg His Val Met 
    50                  55                  60                  


Leu Leu Arg Ala Val Pro Gly Gly Ala Gly Asp Ala Ser Val Leu Pro 
65                  70                  75                  80  


Ser Leu Pro Arg Glu Gly Gln Glu Lys Val Leu Asp Arg Leu Asp Phe 
                85                  90                  95      


Val Leu Thr Ser Leu Val Ala Leu Arg Arg Glu Val Glu Glu Leu Arg 
            100                 105                 110         


Ser Ser Leu Arg Gly Leu Ala Gly Glu Ile Val Gly Glu Val Arg Cys 
        115                 120                 125             


His Met Glu Glu Asn Gln Arg Val Ala Arg Arg Arg Arg Phe Pro Phe 
    130                 135                 140                 


Val Arg Glu Arg Ser Asp Ser Thr Gly Ser Ser Ser Val Tyr Phe Thr 
145                 150                 155                 160 


Ala Ser Ser Gly Ala Thr Phe Thr Asp Ala Glu Ser Glu Gly Gly Tyr 
                165                 170                 175     


Thr Thr Ala Asn Ala Glu Ser Asp Asn Glu Arg Asp Ser Asp Lys Glu 
            180                 185                 190         


Ser Glu Asp Gly Glu Asp Glu Val Ser Cys Glu Thr Val Lys Met Gly 
        195                 200                 205             


Arg Lys Asp Ser Leu Asp Leu Glu Glu Glu Ala Ala Ser Gly Ala Ser 
    210                 215                 220                 


Ser Ala Leu Glu Ala Gly Gly Ser Ser Gly Leu Glu Asp Val Leu Pro 
225                 230                 235                 240 


Leu Leu Gln Gln Ala Asp Glu Leu His Arg Gly Asp Glu Gln Gly Lys 
                245                 250                 255     


Arg Glu Gly Phe Gln Leu Leu Leu Asn Asn Lys Leu Val Tyr Gly Ser 
            260                 265                 270         


Arg Gln Asp Phe Leu Trp Arg Leu Ala Arg Ala Tyr Ser Asp Met Cys 
        275                 280                 285             


Glu Leu Thr Glu Glu Val Ser Glu Lys Lys Ser Tyr Ala Leu Asp Gly 
    290                 295                 300                 


Lys Glu Glu Ala Glu Ala Ala Leu Glu Lys Gly Asp Glu Ser Ala Asp 
305                 310                 315                 320 


Cys His Leu Trp Tyr Ala Val Leu Cys Gly Gln Leu Ala Glu His Glu 
                325                 330                 335     


Ser Ile Gln Arg Arg Ile Gln Ser Gly Phe Ser Phe Lys Glu His Val 
            340                 345                 350         


Asp Lys Ala Ile Ala Leu Gln Pro Glu Asn Pro Met Ala His Phe Leu 
        355                 360                 365             


Leu Gly Arg Trp Cys Tyr Gln Val Ser His Leu Ser Trp Leu Glu Lys 
    370                 375                 380                 


Lys Thr Ala Thr Ala Leu Leu Glu Ser Pro Leu Ser Ala Thr Val Glu 
385                 390                 395                 400 


Asp Ala Leu Gln Ser Phe Leu Lys Ala Glu Glu Leu Gln Pro Gly Phe 
                405                 410                 415     


Ser Lys Ala Gly Arg Val Tyr Ile Ser Lys Cys Tyr Arg Glu Leu Gly 
            420                 425                 430         


Lys Asn Ser Glu Ala Arg Trp Trp Met Lys Leu Ala Leu Glu Leu Pro 
        435                 440                 445             


Asp Val Thr Lys Glu Asp Leu Ala Ile Gln Lys Asp Leu Glu Glu Leu 
    450                 455                 460                 


Glu Val Ile Leu Arg Asp 
465                 470 


<210>  11
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys 
        35                  40                  45              


Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala 
65                  70                  75                  80  


Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg 
                85                  90                  95      


Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu 
            100                 105                 110         


Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val 
        115                 120                 125             


Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly 
    130                 135                 140                 


Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala 
145                 150                 155                 160 


Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln 
                165                 170                 175     


Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser 
            180                 185                 190         


Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly 
        195                 200                 205             


Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly 
    210                 215                 220                 


Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu 
225                 230                 235                 240 


His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser 
                245                 250                 255     


Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln 
            260                 265                 270         


Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg 
        275                 280                 285             


Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala 
    290                 295                 300                 


Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu 
305                 310                 315                 320 


Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
                325                 330                 335     


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys 
            340                 345                 350         


Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg 
        355                 360                 365             


Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala 
    370                 375                 380                 


Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly 
385                 390                 395                 400 


Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr 
                405                 410                 415     


Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg 
            420                 425                 430         


Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe 
        435                 440                 445             


Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly 
    450                 455                 460                 


Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr 
465                 470                 475                 480 


Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
                485                 490                 495 


<210>  12
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Ala Glu Phe Leu Ser Leu Leu Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Tyr Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His 
            20                  25                  30          


Ala Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys 
        35                  40                  45              


Cys Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn 
    50                  55                  60                  


Asp Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu 
65                  70                  75                  80  


Phe Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys 
                85                  90                  95      


Ala Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His 
            100                 105                 110         


Leu Gln Leu Val Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro Ser 
        115                 120                 125             


Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys Ile 
    130                 135                 140                 


Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys Ser 
145                 150                 155                 160 


Gln His Ser Ser Ser Ser Glu Glu Ser Thr Lys Arg Thr Ser His Ser 
                165                 170                 175     


Lys Leu Pro Glu Gln Glu Ala Ala Glu Ala Asp Leu Ser Asn Met Glu 
            180                 185                 190         


Arg Val Ser Leu Ser Thr Ala Asp Pro Gln Gly Val Thr Tyr Ala Glu 
        195                 200                 205             


Leu Ser Thr Ser Ala Leu Ser Glu Ala Ala Ser Asp Thr Thr Gln Glu 
    210                 215                 220                 


Pro Pro Gly Ser His Glu Tyr Ala Ala Leu Lys Val 
225                 230                 235     


<210>  13
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ala Ala Glu Glu Glu Asp Gly Gly Pro Glu Gly Pro Asn Arg 
1               5                   10                  15      


Glu Arg Gly Gly Ala Gly Ala Thr Phe Glu Cys Asn Ile Cys Leu Glu 
            20                  25                  30          


Thr Ala Arg Glu Ala Val Val Ser Val Cys Gly His Leu Tyr Cys Trp 
        35                  40                  45              


Pro Cys Leu His Gln Trp Leu Glu Thr Arg Pro Glu Arg Gln Glu Cys 
    50                  55                  60                  


Pro Val Cys Lys Ala Gly Ile Ser Arg Glu Lys Val Val Pro Leu Tyr 
65                  70                  75                  80  


Gly Arg Gly Ser Gln Lys Pro Gln Asp Pro Arg Leu Lys Thr Pro Pro 
                85                  90                  95      


Arg Pro Gln Gly Gln Arg Pro Ala Pro Glu Ser Arg Gly Gly Phe Gln 
            100                 105                 110         


Pro Phe Gly Asp Thr Gly Gly Phe His Phe Ser Phe Gly Val Gly Ala 
        115                 120                 125             


Phe Pro Phe Gly Phe Phe Thr Thr Val Phe Asn Ala His Glu Pro Phe 
    130                 135                 140                 


Arg Arg Gly Thr Gly Val Asp Leu Gly Gln Gly His Pro Ala Ser Ser 
145                 150                 155                 160 


Trp Gln Asp Ser Leu Phe Leu Phe Leu Ala Ile Phe Phe Phe Phe Trp 
                165                 170                 175     


Leu Leu Ser Ile 
            180 


<210>  14
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Pro Glu Gln Gly Pro Gln Pro Ser Thr Met Pro Leu Trp Cys 
1               5                   10                  15      


Leu Leu Ala Ala Cys Thr Ser Leu Pro Arg Gln Ala Ala Thr Met Leu 
            20                  25                  30          


Glu Glu Ala Ala Ser Pro Asn Glu Ala Val His Ala Ser Thr Ser Gly 
        35                  40                  45              


Ser Gly Ala Leu Thr Asp Gln Thr Phe Thr Asp Leu Ser Ala Ala Glu 
    50                  55                  60                  


Ala Ser Ser Glu Glu Val Pro Asp Phe Met Glu Val Pro His Ser Val 
65                  70                  75                  80  


His His Lys Ile Asn Cys Phe Phe Tyr Leu Glu Lys Gln Leu Cys Gln 
                85                  90                  95      


Leu Pro Ser Pro Leu Cys Leu Ser Ser Leu Leu Thr Leu Lys Leu Lys 
            100                 105                 110         


Thr Thr Val Pro Ala Pro Gly Arg Trp Trp Ser Phe Gln Pro His Lys 
        115                 120                 125             


Ala Phe Pro Leu Leu Val Gly Thr Pro Gly Ser Trp Gln Ser Thr Ile 
    130                 135                 140                 


Asp Pro Ala Trp Ala Ala Pro Ser Gln Pro Ser Pro Gly 
145                 150                 155         


<210>  15
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Met Ser Ile Arg Gln Arg Arg Glu Ile Arg Ala Thr Glu Val Ser 
1               5                   10                  15      


Glu Asp Phe Pro Ala Gln Glu Glu Asn Val Lys Leu Glu Asn Lys Leu 
            20                  25                  30          


Pro Ser Gly Cys Thr Ser Arg Arg Leu Trp Lys Ile Leu Ser Leu Thr 
        35                  40                  45              


Ile Gly Gly Thr Ile Ala Leu Cys Ile Gly Leu Leu Thr Ser Val Tyr 
    50                  55                  60                  


Leu Ala Thr Leu His Glu Asn Asp Leu Trp Phe Ser Asn Ile Lys Glu 
65                  70                  75                  80  


Val Glu Arg Glu Ile Ser Phe Arg Thr Glu Cys Gly Leu Tyr Tyr Ser 
                85                  90                  95      


Tyr Tyr Lys Gln Met Leu Gln Ala Pro Thr Leu Val Gln Gly Phe His 
            100                 105                 110         


Gly Leu Ile Tyr Asp Asn Lys Thr Glu Ser Met Lys Thr Ile Asn Leu 
        115                 120                 125             


Leu Gln Arg Met Asn Ile Tyr Gln Glu Val Phe Leu Ser Ile Leu Tyr 
    130                 135                 140                 


Arg Val Leu Pro Ile Gln Lys Tyr Leu Glu Pro Val Tyr Phe Tyr Ile 
145                 150                 155                 160 


Tyr Thr Leu Phe Gly Leu Gln Ala Ile Tyr Val Thr Ala Leu Tyr Ile 
                165                 170                 175     


Thr Ser Trp Leu Leu Ser Gly Thr Trp Leu Ser Gly Leu Leu Ala Ala 
            180                 185                 190         


Phe Trp Tyr Val Thr Asn Arg Ile Asp Thr Thr Arg Val Glu Phe Thr 
        195                 200                 205             


Ile Pro Leu Arg Glu Asn Trp Ala Leu Pro Phe Phe Ala Ile Gln Ile 
    210                 215                 220                 


Ala Ala Ile Thr Tyr Phe Leu Arg Pro Asn Leu Gln Pro Leu Ser Glu 
225                 230                 235                 240 


Arg Leu Thr Leu Leu Ala Ile Phe Ile Ser Thr Phe Leu Phe Ser Leu 
                245                 250                 255     


Thr Trp Gln Phe Asn Gln Phe Met Met Leu Met Gln Ala Leu Val Leu 
            260                 265                 270         


Phe Thr Leu Asp Ser Leu Asp Met Leu Pro Ala Val Lys Ala Thr Trp 
        275                 280                 285             


Leu Tyr Gly Ile Gln Ile Thr Ser Leu Leu Leu Val Cys Ile Leu Gln 
    290                 295                 300                 


Phe Phe Asn Ser Met Ile Leu Gly Ser Leu Leu Ile Ser Phe Asn Leu 
305                 310                 315                 320 


Ser Val Phe Ile Ala Arg Lys Leu Gln Lys Asn Leu Lys Thr Gly Ser 
                325                 330                 335     


Phe Leu Asn Arg Leu Gly Lys Leu Leu Leu His Leu Phe Met Val Leu 
            340                 345                 350         


Cys Leu Thr Leu Phe Leu Asn Asn Ile Ile Lys Lys Ile Leu Asn Leu 
        355                 360                 365             


Lys Ser Asp Glu His Ile Phe Lys Phe Leu Lys Ala Lys Phe Gly Leu 
    370                 375                 380                 


Gly Ala Thr Arg Asp Phe Asp Ala Asn Leu Tyr Leu Cys Glu Glu Ala 
385                 390                 395                 400 


Phe Gly Leu Leu Pro Phe Asn Thr Phe Gly Arg Leu Ser Asp Thr Leu 
                405                 410                 415     


Leu Phe Tyr Ala Tyr Ile Phe Val Leu Ser Ile Thr Val Ile Val Ala 
            420                 425                 430         


Phe Val Val Ala Phe His Asn Leu Ser Asp Ser Thr Asn Gln Gln Ser 
        435                 440                 445             


Val Gly Lys Met Glu Lys Gly Thr Val Asp Leu Lys Pro Glu Thr Ala 
    450                 455                 460                 


Tyr Asn Leu Ile His Thr Ile Leu Phe Gly Phe Leu Ala Leu Ser Thr 
465                 470                 475                 480 


Met Arg Met Lys Tyr Leu Trp Thr Ser His Met Cys Val Phe Ala Ser 
                485                 490                 495     


Phe Gly Leu Cys Ser Pro Glu Ile Trp Glu Leu Leu Leu Lys Ser Val 
            500                 505                 510         


His Leu Tyr Asn Pro Lys Arg Ile Cys Ile Met Arg Tyr Ser Val Pro 
        515                 520                 525             


Ile Leu Ile Leu Leu Tyr Leu Cys Tyr Lys Phe Trp Pro Gly Met Met 
    530                 535                 540                 


Asp Glu Leu Ser Glu Leu Arg Glu Phe Tyr Asp Pro Asp Thr Val Glu 
545                 550                 555                 560 


Leu Met Asn Trp Ile Asn Ser Asn Thr Pro Arg Lys Ala Val Phe Ala 
                565                 570                 575     


Gly Ser Met Gln Leu Leu Ala Gly Val Lys Leu Cys Thr Gly Arg Thr 
            580                 585                 590         


Leu Thr Asn His Pro His Tyr Glu Asp Ser Ser Leu Arg Glu Arg Thr 
        595                 600                 605             


Arg Ala Val Tyr Gln Ile Tyr Ala Lys Arg Ala Pro Glu Glu Val His 
    610                 615                 620                 


Ala Leu Leu Arg Ser Phe Gly Thr Asp Tyr Val Ile Leu Glu Asp Ser 
625                 630                 635                 640 


Ile Cys Tyr Glu Arg Arg His Arg Arg Gly Cys Arg Leu Arg Asp Leu 
                645                 650                 655     


Leu Asp Ile Ala Asn Gly His Met Met Asp Gly Pro Gly Glu Asn Asp 
            660                 665                 670         


Pro Asp Leu Lys Pro Ala Asp His Pro Arg Phe Cys Glu Glu Ile Lys 
        675                 680                 685             


Arg Asn Leu Pro Pro Tyr Val Ala Tyr Phe Thr Arg Val Phe Gln Asn 
    690                 695                 700                 


Lys Thr Phe His Val Tyr Lys Leu Ser Arg Asn Lys 
705                 710                 715     


<210>  16
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Val His Met His Thr Lys Phe Cys Leu Ile Cys Leu Leu Thr 
1               5                   10                  15      


Phe Ile Phe His His Cys Asn His Cys His Glu Glu His Asp His Gly 
            20                  25                  30          


Pro Glu Ala Leu His Arg Gln His Arg Gly Met Thr Glu Leu Glu Pro 
        35                  40                  45              


Ser Lys Phe Ser Lys Gln Ala Ala Glu Asn Glu Lys Lys Tyr Tyr Ile 
    50                  55                  60                  


Glu Lys Leu Phe Glu Arg Tyr Gly Glu Asn Gly Arg Leu Ser Phe Phe 
65                  70                  75                  80  


Gly Leu Glu Lys Leu Leu Thr Asn Leu Gly Leu Gly Glu Arg Lys Val 
                85                  90                  95      


Val Glu Ile Asn His Glu Asp Leu Gly His Asp His Val Ser His Leu 
            100                 105                 110         


Asp Ile Leu Ala Val Gln Glu Gly Lys His Phe His Ser His Asn His 
        115                 120                 125             


Gln His Ser His Asn His Leu Asn Ser Glu Asn Gln Thr Val Thr Ser 
    130                 135                 140                 


Val Ser Thr Lys Arg Asn His Lys Cys Asp Pro Glu Lys Glu Thr Val 
145                 150                 155                 160 


Glu Val Ser Val Lys Ser Asp Asp Lys His Met His Asp His Asn His 
                165                 170                 175     


Arg Leu Arg His His His Arg Leu His His His Leu Asp His Asn Asn 
            180                 185                 190         


Thr His His Phe His Asn Asp Ser Ile Thr Pro Ser Glu Arg Gly Glu 
        195                 200                 205             


Pro Ser Asn Glu Pro Ser Thr Glu Thr Asn Lys Thr Gln Glu Gln Ser 
    210                 215                 220                 


Asp Val Lys Leu Pro Lys Gly Lys Arg Lys Lys Lys Gly Arg Lys Ser 
225                 230                 235                 240 


Asn Glu Asn Ser Glu Val Ile Thr Pro Gly Phe Pro Pro Asn His Asp 
                245                 250                 255     


Gln Gly Glu Gln Tyr Glu His Asn Arg Val His Lys Pro Asp Arg Val 
            260                 265                 270         


His Asn Pro Gly His Ser His Val His Leu Pro Glu Arg Asn Gly His 
        275                 280                 285             


Asp Pro Gly Arg Gly His Gln Asp Leu Asp Pro Asp Asn Glu Gly Glu 
    290                 295                 300                 


Leu Arg His Thr Arg Lys Arg Glu Ala Pro His Val Lys Asn Asn Ala 
305                 310                 315                 320 


Ile Ile Ser Leu Arg Lys Asp Leu Asn Glu Asp Asp His His His Glu 
                325                 330                 335     


Cys Leu Asn Val Thr Gln Leu Leu Lys Tyr Tyr Gly His Gly Ala Asn 
            340                 345                 350         


Ser Pro Ile Ser Thr Asp Leu Phe Thr Tyr Leu Cys Pro Ala Leu Leu 
        355                 360                 365             


Tyr Gln Ile Asp Ser Arg Leu Cys Ile Glu His Phe Asp Lys Leu Leu 
    370                 375                 380                 


Val Glu Asp Ile Asn Lys Asp Lys Asn Leu Val Pro Glu Asp Glu Ala 
385                 390                 395                 400 


Asn Ile Gly Ala Ser Ala Trp Ile Cys Gly Ile Ile Ser Ile Thr Val 
                405                 410                 415     


Ile Ser Leu Leu Ser Leu Leu Gly Val Ile Leu Val Pro Ile Ile Asn 
            420                 425                 430         


Gln Gly Cys Phe Lys Phe Leu Leu Thr Phe Leu Val Ala Leu Ala Val 
        435                 440                 445             


Gly Thr Met Ser Gly Asp Ala Leu Leu His Leu Leu Pro His Ser Gln 
    450                 455                 460                 


Gly Gly His Asp His Ser His Gln His Ala His Gly His Gly His Ser 
465                 470                 475                 480 


His Gly His Glu Ser Asn Lys Phe Leu Glu Glu Tyr Asp Ala Val Leu 
                485                 490                 495     


Lys Gly Leu Val Ala Leu Gly Gly Ile Tyr Leu Leu Phe Ile Ile Glu 
            500                 505                 510         


His Cys Ile Arg Met Phe Lys His Tyr Lys Gln Gln Arg Gly Lys Gln 
        515                 520                 525             


Lys Trp Phe Met Lys Gln Asn Thr Glu Glu Ser Thr Ile Gly Arg Lys 
    530                 535                 540                 


Leu Ser Asp His Lys Leu Asn Asn Thr Pro Asp Ser Asp Trp Leu Gln 
545                 550                 555                 560 


Leu Lys Pro Leu Ala Gly Thr Asp Asp Ser Val Val Ser Glu Asp Arg 
                565                 570                 575     


Leu Asn Glu Thr Glu Leu Thr Asp Leu Glu Gly Gln Gln Glu Ser Pro 
            580                 585                 590         


Pro Lys Asn Tyr Leu Cys Ile Glu Glu Glu Lys Ile Ile Asp His Ser 
        595                 600                 605             


His Ser Asp Gly Leu His Thr Ile His Glu His Asp Leu His Ala Ala 
    610                 615                 620                 


Ala His Asn His His Gly Glu Asn Lys Thr Val Leu Arg Lys His Asn 
625                 630                 635                 640 


His Gln Trp His His Lys His Ser His His Ser His Gly Pro Cys His 
                645                 650                 655     


Ser Gly Ser Asp Leu Lys Glu Thr Gly Ile Ala Asn Ile Ala Trp Met 
            660                 665                 670         


Val Ile Met Gly Asp Gly Ile His Asn Phe Ser Asp Gly Leu Ala Ile 
        675                 680                 685             


Gly Ala Ala Phe Ser Ala Gly Leu Thr Gly Gly Ile Ser Thr Ser Ile 
    690                 695                 700                 


Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Val 
705                 710                 715                 720 


Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Ile Val Tyr Asn Leu 
                725                 730                 735     


Leu Ser Ala Met Met Ala Tyr Ile Gly Met Leu Ile Gly Thr Ala Val 
            740                 745                 750         


Gly Gln Tyr Ala Asn Asn Ile Thr Leu Trp Ile Phe Ala Val Thr Ala 
        755                 760                 765             


Gly Met Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Glu Met Leu 
    770                 775                 780                 


His Gly Asp Gly Asp Asn Glu Glu His Gly Phe Cys Pro Val Gly Gln 
785                 790                 795                 800 


Phe Ile Leu Gln Asn Leu Gly Leu Leu Phe Gly Phe Ala Ile Met Leu 
                805                 810                 815     


Val Ile Ala Leu Tyr Glu Asp Lys Ile Val Phe Asp Ile Gln Phe 
            820                 825                 830     


<210>  17
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg 
1               5                   10                  15      


Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu 
            20                  25                  30          


Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp 
        35                  40                  45              


Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp 
    50                  55                  60                  


Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu 
65                  70                  75                  80  


Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp 
                85                  90                  95      


Gly Phe Ser Ser Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys 
            100                 105                 110         


Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser 
        115                 120                 125             


Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys 
    130                 135                 140                 


Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro 
145                 150                 155                 160 


Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp 
                165                 170                 175     


Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu 
            180                 185                 190         


Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe 
        195                 200                 205             


Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr 
    210                 215                 220                 


Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser 
                245                 250                 255     


Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe 
            260                 265                 270         


Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg 
        275                 280                 285             


Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr 
    290                 295                 300                 


Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser 
305                 310                 315                 320 


Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr 
                325                 330                 335     


His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly 
            340                 345                 350         


Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys 
        355                 360                 365             


Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr 
    370                 375                 380                 


Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp 
385                 390                 395                 400 


Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu 
                405                 410                 415     


Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr 
            420                 425                 430         


Asp Gly Lys Gly Asp Ser Met Gly Pro Leu Gln Gln Arg Ala Asn Leu 
        435                 440                 445             


Arg Ala Gly Ser Arg Ile Glu Ser His His Phe Ala Gln Ala Asp Leu 
    450                 455                 460                 


Glu Leu Leu Ala Ser Ser Cys Pro Pro Ala Ser Val Ser Gln Arg Ala 
465                 470                 475                 480 


Gly Ile Thr Ala Ala Ile Asn Leu Ala Lys Leu Lys Leu Phe Arg His 
                485                 490                 495     


Tyr Tyr Val Leu Ile Val Cys Tyr Ile Tyr Phe Thr Arg Ile Ile Ala 
            500                 505                 510         


Phe Leu Leu Lys Leu Ala Val Pro Phe Gln Trp Lys Trp Leu Tyr Gln 
        515                 520                 525             


Leu Leu Asp Glu Thr Ala Thr Leu Val Phe Phe Val Leu Thr Gly Tyr 
    530                 535                 540                 


Lys Phe Arg Pro Ala Ser Asp Asn Pro Tyr Leu Gln Leu Ser Gln Glu 
545                 550                 555                 560 


Glu Glu Asp Leu Glu Met Glu Ser Val Val Thr Thr Ser Gly Val Met 
                565                 570                 575     


Glu Ser Met Lys Lys Val Lys Lys Val Thr Asn Gly Ser Val Glu Pro 
            580                 585                 590         


Gln Gly Glu Trp Glu Gly Ala Val 
        595                 600 


<210>  18
<211>  1284
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp 
1               5                   10                  15      


Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu 
            20                  25                  30          


Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu 
        35                  40                  45              


Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala 
    50                  55                  60                  


Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala 
65                  70                  75                  80  


Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe 
                85                  90                  95      


Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val 
            100                 105                 110         


Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro 
        115                 120                 125             


Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro 
    130                 135                 140                 


Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln 
145                 150                 155                 160 


Asp Pro Arg Thr Pro Ala Gly Pro Gln Phe Arg Cys Leu Pro Pro Val 
                165                 170                 175     


Pro Ala Asp Met Val Phe Leu Val Asp Gly Ser Trp Ser Ile Gly His 
            180                 185                 190         


Ser His Phe Gln Gln Val Lys Asp Phe Leu Ala Ser Val Ile Ala Pro 
        195                 200                 205             


Phe Glu Ile Gly Pro Asp Lys Val Gln Val Gly Leu Thr Gln Tyr Ser 
    210                 215                 220                 


Gly Asp Ala Gln Thr Glu Trp Asp Leu Asn Ser Leu Ser Thr Lys Glu 
225                 230                 235                 240 


Gln Val Leu Ala Ala Val Arg Arg Leu Arg Tyr Lys Gly Gly Asn Thr 
                245                 250                 255     


Phe Thr Gly Leu Ala Leu Thr His Val Leu Gly Gln Asn Leu Gln Pro 
            260                 265                 270         


Ala Ala Gly Leu Arg Pro Glu Ala Ala Lys Val Val Ile Leu Val Thr 
        275                 280                 285             


Asp Gly Lys Ser Gln Asp Asp Val His Thr Ala Ala Arg Val Leu Lys 
    290                 295                 300                 


Asp Leu Gly Val Asn Val Phe Ala Val Gly Val Lys Asn Ala Asp Glu 
305                 310                 315                 320 


Ala Glu Leu Arg Leu Leu Ala Ser Pro Pro Arg Asp Ile Thr Val His 
                325                 330                 335     


Ser Val Leu Asp Phe Leu Gln Leu Gly Ala Leu Ala Gly Leu Leu Ser 
            340                 345                 350         


Arg Leu Ile Cys Gln Arg Leu Gln Gly Gly Ser Pro Arg Gln Gly Pro 
        355                 360                 365             


Ala Ala Ala Pro Ala Leu Asp Thr Leu Pro Ala Pro Thr Ser Leu Val 
    370                 375                 380                 


Leu Ser Gln Val Thr Ser Ser Ser Ile Arg Leu Ser Trp Thr Pro Ala 
385                 390                 395                 400 


Pro Arg His Pro Leu Lys Tyr Leu Ile Val Trp Arg Ala Ser Arg Gly 
                405                 410                 415     


Gly Thr Pro Arg Glu Val Val Val Glu Gly Pro Ala Ala Ser Thr Glu 
            420                 425                 430         


Leu His Asn Leu Ala Ser Arg Thr Glu Tyr Leu Val Ser Val Phe Pro 
        435                 440                 445             


Ile Tyr Glu Gly Gly Val Gly Glu Gly Leu Arg Gly Leu Val Thr Thr 
    450                 455                 460                 


Ala Pro Leu Pro Pro Pro Arg Ala Leu Thr Leu Ala Ala Val Thr Pro 
465                 470                 475                 480 


Arg Thr Val His Leu Thr Trp Gln Pro Ser Ala Gly Ala Thr His Tyr 
                485                 490                 495     


Leu Val Arg Cys Ser Pro Ala Ser Pro Lys Gly Glu Glu Glu Glu Arg 
            500                 505                 510         


Glu Val Gln Val Gly Arg Pro Glu Val Leu Leu Asp Gly Leu Glu Pro 
        515                 520                 525             


Gly Arg Asp Tyr Glu Val Ser Val Gln Ser Leu Arg Gly Pro Glu Gly 
    530                 535                 540                 


Ser Glu Ala Arg Gly Ile Arg Ala Arg Thr Pro Thr Leu Ala Pro Pro 
545                 550                 555                 560 


Arg His Leu Gly Phe Ser Asp Val Ser His Asp Ala Ala Arg Val Phe 
                565                 570                 575     


Trp Glu Gly Ala Pro Arg Pro Val Arg Leu Val Arg Val Thr Tyr Val 
            580                 585                 590         


Ser Ser Glu Gly Gly His Ser Gly Gln Thr Glu Ala Pro Gly Asn Ala 
        595                 600                 605             


Thr Ser Ala Thr Leu Gly Pro Leu Ser Ser Ser Thr Thr Tyr Thr Val 
    610                 615                 620                 


Arg Val Thr Cys Leu Tyr Pro Gly Gly Gly Ser Ser Thr Leu Thr Gly 
625                 630                 635                 640 


Arg Val Thr Thr Lys Lys Ala Pro Ser Pro Ser Gln Leu Ser Met Thr 
                645                 650                 655     


Glu Leu Pro Gly Asp Ala Val Gln Leu Ala Trp Val Ala Ala Ala Pro 
            660                 665                 670         


Ser Gly Val Leu Val Tyr Gln Ile Thr Trp Thr Pro Leu Gly Glu Gly 
        675                 680                 685             


Lys Ala His Glu Ile Ser Val Pro Gly Asn Leu Gly Thr Ala Val Leu 
    690                 695                 700                 


Pro Gly Leu Gly Arg His Thr Glu Tyr Asp Val Thr Ile Leu Ala Tyr 
705                 710                 715                 720 


Tyr Arg Asp Gly Ala Arg Ser Asp Pro Val Ser Leu Arg Tyr Thr Pro 
                725                 730                 735     


Ser Thr Val Ser Arg Ser Pro Pro Ser Asn Leu Ala Leu Ala Ser Glu 
            740                 745                 750         


Thr Pro Asp Ser Leu Gln Val Ser Trp Thr Pro Pro Leu Gly Arg Val 
        755                 760                 765             


Leu His Tyr Trp Leu Thr Tyr Ala Pro Ala Ser Gly Leu Gly Pro Glu 
    770                 775                 780                 


Lys Ser Val Ser Val Pro Gly Ala Arg Ser His Val Thr Leu Pro Asp 
785                 790                 795                 800 


Leu Gln Ala Ala Thr Lys Tyr Arg Val Leu Val Ser Ala Ile Tyr Ala 
                805                 810                 815     


Ala Gly Arg Ser Glu Ala Val Ser Ala Thr Gly Gln Thr Ala Cys Pro 
            820                 825                 830         


Ala Leu Arg Pro Asp Gly Ser Leu Pro Gly Phe Asp Leu Met Val Ala 
        835                 840                 845             


Phe Ser Leu Val Glu Lys Ala Tyr Ala Ser Ile Arg Gly Val Ala Met 
    850                 855                 860                 


Glu Pro Ser Ala Phe Gly Gly Thr Pro Thr Phe Thr Leu Phe Lys Asp 
865                 870                 875                 880 


Ala Gln Leu Thr Arg Arg Val Ser Asp Val Tyr Pro Ala Pro Leu Pro 
                885                 890                 895     


Pro Glu His Thr Ile Val Phe Leu Val Arg Leu Leu Pro Glu Thr Pro 
            900                 905                 910         


Arg Glu Ala Phe Ala Leu Trp Gln Met Thr Ala Glu Asp Phe Gln Pro 
        915                 920                 925             


Leu Leu Gly Val Leu Leu Asp Ala Gly Lys Lys Ser Leu Thr Tyr Phe 
    930                 935                 940                 


His Arg Asp Pro Arg Ala Ala Leu Gln Glu Ala Thr Phe Asp Pro Gln 
945                 950                 955                 960 


Glu Val Arg Lys Ile Phe Phe Gly Ser Phe His Lys Val His Val Ala 
                965                 970                 975     


Val Gly Arg Ser Lys Val Arg Leu Tyr Val Asp Cys Arg Lys Val Ala 
            980                 985                 990         


Glu Arg Pro Leu Gly Glu Met Gly  Ser Pro Pro Ala Ala  Gly Phe Val 
        995                 1000                 1005             


Thr Leu  Gly Arg Leu Ala Lys  Ala Arg Gly Pro Arg  Ser Ser Ser 
    1010                 1015                 1020             


Ala Ala  Phe Gln Leu Gln Met  Leu Gln Ile Val Cys  Ser Asp Thr 
    1025                 1030                 1035             


Trp Ala  Asp Glu Asp Arg Cys  Cys Glu Leu Pro Ala  Ser Arg Asp 
    1040                 1045                 1050             


Gly Glu  Thr Cys Pro Ala Phe  Val Ser Ala Cys Ser  Cys Ser Ser 
    1055                 1060                 1065             


Glu Thr  Pro Gly Pro Pro Gly  Pro Gln Gly Pro Pro  Gly Leu Pro 
    1070                 1075                 1080             


Gly Arg  Asn Gly Thr Pro Gly  Glu Gln Gly Phe Pro  Gly Pro Arg 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Lys Gly  Glu Lys Gly Asp His  Gly Leu Pro 
    1100                 1105                 1110             


Gly Leu  Gln Gly His Pro Gly  His Gln Gly Ile Pro  Gly Arg Val 
    1115                 1120                 1125             


Gly Leu  Gln Gly Pro Lys Gly  Met Arg Gly Leu Glu  Gly Thr Ala 
    1130                 1135                 1140             


Gly Leu  Pro Gly Pro Pro Gly  Pro Arg Gly Phe Gln  Gly Met Ala 
    1145                 1150                 1155             


Gly Ala  Arg Gly Thr Ser Gly  Glu Arg Gly Pro Pro  Gly Thr Val 
    1160                 1165                 1170             


Gly Pro  Thr Gly Leu Pro Gly  Pro Lys Gly Glu Arg  Gly Glu Lys 
    1175                 1180                 1185             


Gly Glu  Pro Gln Ser Leu Ala  Thr Leu Tyr Gln Leu  Val Ser Gln 
    1190                 1195                 1200             


Ala Ser  His Val Ser Lys Phe  Asp Ser Phe His Glu  Asn Thr Arg 
    1205                 1210                 1215             


Pro Pro  Met Pro Ile Leu Glu  Gln Lys Leu Glu Pro  Gly Thr Glu 
    1220                 1225                 1230             


Pro Leu  Gly Ser Pro Gly Thr  Arg Ser Lys Ala Leu  Val Pro Gly 
    1235                 1240                 1245             


Glu Trp  Gly Arg Gly Gly Arg  His Leu Glu Gly Arg  Gly Glu Pro 
    1250                 1255                 1260             


Gly Ala  Val Gly Gln Met Gly  Ser Pro Gly Gln Gln  Gly Ala Ser 
    1265                 1270                 1275             


Thr Gln  Gly Leu Trp Glu 
    1280                 


<210>  19
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Arg Pro Ala Ala Thr Leu Ala Trp Ser Leu Leu Leu Leu 
1               5                   10                  15      


Ser Ser Ala Leu Leu Arg Glu Gly Cys Arg Ala Arg Phe Val Ala Glu 
            20                  25                  30          


Arg Asp Ser Glu Asp Asp Gly Glu Glu Pro Val Val Phe Pro Glu Ser 
        35                  40                  45              


Pro Leu Gln Ser Pro Thr Val Leu Val Ala Val Leu Ala Arg Asn Ala 
    50                  55                  60                  


Ala His Thr Leu Pro His Phe Leu Gly Cys Leu Glu Arg Leu Asp Tyr 
65                  70                  75                  80  


Pro Lys Ser Arg Met Ala Ile Trp Ala Ala Thr Asp His Asn Val Asp 
                85                  90                  95      


Asn Thr Thr Glu Ile Phe Arg Glu Trp Leu Lys Asn Val Gln Arg Leu 
            100                 105                 110         


Tyr His Tyr Val Glu Trp Arg Pro Met Asp Glu Pro Glu Ser Tyr Pro 
        115                 120                 125             


Asp Glu Ile Gly Pro Lys His Trp Pro Thr Ser Arg Phe Ala His Val 
    130                 135                 140                 


Met Lys Leu Arg Gln Ala Ala Leu Arg Thr Ala Arg Glu Lys Trp Ser 
145                 150                 155                 160 


Asp Tyr Ile Leu Phe Ile Asp Val Asp Asn Phe Leu Thr Asn Pro Gln 
                165                 170                 175     


Thr Leu Asn Leu Leu Ile Ala Glu Asn Lys Thr Ile Val Ala Pro Met 
            180                 185                 190         


Leu Glu Ser Arg Gly Leu Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro 
        195                 200                 205             


Lys Gly Phe Tyr Lys Arg Thr Pro Asp Tyr Val Gln Ile Arg Glu Trp 
    210                 215                 220                 


Lys Arg Thr Gly Cys Phe Pro Val Pro Met Val His Ser Thr Phe Leu 
225                 230                 235                 240 


Ile Asp Leu Arg Lys Glu Ala Ser Asp Lys Leu Thr Phe Tyr Pro Pro 
                245                 250                 255     


His Gln Asp Tyr Thr Trp Thr Phe Asp Asp Ile Ile Val Phe Ala Phe 
            260                 265                 270         


Ser Ser Arg Gln Ala Gly Ile Gln Met Tyr Leu Cys Asn Arg Glu His 
        275                 280                 285             


Tyr Gly Tyr Leu Pro Ile Pro Leu Lys Pro His Gln Thr Leu Gln Glu 
    290                 295                 300                 


Asp Ile Glu Asn Leu Ile His Val Gln Ile Glu Ala Met Ile Asp Arg 
305                 310                 315                 320 


Pro Pro Met Glu Pro Ser Gln Tyr Val Ser Val Val Pro Lys Tyr Pro 
                325                 330                 335     


Asp Lys Met Gly Phe Asp Glu Ile Phe Met Ile Asn Leu Lys Arg Arg 
            340                 345                 350         


Lys Asp Arg Arg Asp Arg Met Leu Arg Thr Leu Tyr Glu Gln Glu Ile 
        355                 360                 365             


Glu Val Lys Ile Val Glu Ala Val Asp Gly Lys Ala Leu Asn Thr Ser 
    370                 375                 380                 


Gln Leu Lys Ala Leu Asn Ile Glu Met Leu Pro Gly Tyr Arg Asp Pro 
385                 390                 395                 400 


Tyr Ser Ser Arg Pro Leu Thr Arg Gly Glu Ile Gly Cys Phe Leu Ser 
                405                 410                 415     


His Tyr Ser Val Trp Lys Glu Val Ile Asp Arg Glu Leu Glu Lys Thr 
            420                 425                 430         


Leu Val Ile Glu Asp Asp Val Arg Phe Glu His Gln Phe Lys Lys Lys 
        435                 440                 445             


Leu Met Lys Leu Met Asp Asn Ile Asp Gln Ala Gln Leu Asp Trp Glu 
    450                 455                 460                 


Leu Ile Tyr Ile Gly Arg Lys Arg Met Gln Val Lys Glu Pro Glu Lys 
465                 470                 475                 480 


Ala Val Pro Asn Val Ala Asn Leu Val Glu Ala Asp Tyr Ser Tyr Trp 
                485                 490                 495     


Thr Leu Gly Tyr Val Ile Ser Leu Glu Gly Ala Gln Lys Leu Val Gly 
            500                 505                 510         


Ala Asn Pro Phe Gly Lys Met Leu Pro Val Asp Glu Phe Leu Pro Val 
        515                 520                 525             


Met Tyr Asn Lys His Pro Val Ala Glu Tyr Lys Glu Tyr Tyr Glu Ser 
    530                 535                 540                 


Arg Asp Leu Lys Ala Phe Ser Ala Glu Pro Leu Leu Ile Tyr Pro Thr 
545                 550                 555                 560 


His Tyr Thr Gly Gln Pro Gly Tyr Leu Ser Asp Thr Glu Thr Ser Thr 
                565                 570                 575     


Ile Trp Asp Asn Glu Thr Val Ala Thr Asp Trp Asp Arg Thr His Ala 
            580                 585                 590         


Trp Lys Ser Arg Lys Gln Ser Arg Ile Tyr Ser Asn Ala Lys Asn Thr 
        595                 600                 605             


Glu Ala Leu Pro Pro Pro Thr Ser Leu Asp Thr Val Pro Ser Arg Asp 
    610                 615                 620                 


Glu Leu 
625     


<210>  20
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Gln Glu Ile Asp Leu Ser Ala Leu Lys Glu Leu Glu Arg Glu 
1               5                   10                  15      


Ala Ile Leu Gln Val Leu Tyr Arg Asp Gln Ala Val Gln Asn Thr Glu 
            20                  25                  30          


Glu Glu Arg Thr Arg Lys Leu Lys Thr His Leu Gln His Leu Arg Trp 
        35                  40                  45              


Lys Gly Ala Lys Asn Thr Asp Trp Glu His Lys Glu Lys Cys Cys Ala 
    50                  55                  60                  


Arg Cys Gln Gln Val Leu Gly Phe Leu Leu His Arg Gly Ala Val Cys 
65                  70                  75                  80  


Arg Gly Cys Ser His Arg Val Cys Ala Gln Cys Arg Val Phe Leu Arg 
                85                  90                  95      


Gly Thr His Ala Trp Lys Cys Thr Val Cys Phe Glu Asp Arg Asn Val 
            100                 105                 110         


Lys Ile Lys Thr Gly Glu Trp Phe Tyr Glu Glu Arg Ala Lys Lys Phe 
        115                 120                 125             


Pro Thr Gly Gly Lys His Glu Thr Val Gly Gly Gln Leu Leu Gln Ser 
    130                 135                 140                 


Tyr Gln Lys Leu Ser Lys Ile Ser Val Val Pro Pro Thr Pro Pro Pro 
145                 150                 155                 160 


Val Ser Glu Ser Gln Cys Ser Arg Ser Pro Gly Arg Leu Gln Glu Phe 
                165                 170                 175     


Gly Gln Phe Arg Gly Phe Asn Lys Ser Val Glu Asn Leu Phe Leu Ser 
            180                 185                 190         


Leu Ala Thr His Val Lys Lys Leu Ser Lys Ser Gln Asn Asp Met Thr 
        195                 200                 205             


Ser Glu Lys His Leu Leu Ala Thr Gly Pro Arg Gln Cys Val Gly Gln 
    210                 215                 220                 


Thr Glu Arg Arg Ser Gln Ser Asp Thr Ala Val Asn Val Thr Thr Arg 
225                 230                 235                 240 


Lys Val Ser Ala Pro Asp Ile Leu Lys Pro Leu Asn Gln Glu Asp Pro 
                245                 250                 255     


Lys Cys Ser Thr Asn Pro Ile Leu Lys Gln Gln Asn Leu Pro Ser Ser 
            260                 265                 270         


Pro Ala Pro Ser Thr Ile Phe Ser Gly Gly Phe Arg His Gly Ser Leu 
        275                 280                 285             


Ile Ser Ile Asp Ser Thr Cys Thr Glu Met Gly Asn Phe Asp Asn Ala 
    290                 295                 300                 


Asn Val Thr Gly Glu Ile Glu Phe Ala Ile His Tyr Cys Phe Lys Thr 
305                 310                 315                 320 


His Ser Leu Glu Ile Cys Ile Lys Ala Cys Lys Asn Leu Ala Tyr Gly 
                325                 330                 335     


Glu Glu Lys Lys Lys Lys Cys Asn Pro Tyr Val Lys Thr Tyr Leu Leu 
            340                 345                 350         


Pro Asp Arg Ser Ser Gln Gly Lys Arg Lys Thr Gly Val Gln Arg Asn 
        355                 360                 365             


Thr Val Asp Pro Thr Phe Gln Glu Thr Leu Lys Tyr Gln Val Ala Pro 
    370                 375                 380                 


Ala Gln Leu Val Thr Arg Gln Leu Gln Val Ser Val Trp His Leu Gly 
385                 390                 395                 400 


Thr Leu Ala Arg Arg Val Phe Leu Gly Glu Val Ile Ile Pro Leu Ala 
                405                 410                 415     


Thr Trp Asp Phe Glu Asp Ser Thr Thr Gln Ser Phe Arg Trp His Pro 
            420                 425                 430         


Leu Arg Ala Lys Ala Glu Lys Tyr Glu Asp Ser Val Pro Gln Ser Asn 
        435                 440                 445             


Gly Glu Leu Thr Val Arg Ala Lys Leu Val Leu Pro Ser Arg Pro Arg 
    450                 455                 460                 


Lys Leu Gln Glu Ala Gln Glu Gly Thr Asp Gln Pro Ser Leu His Gly 
465                 470                 475                 480 


Gln Leu Cys Leu Val Val Leu Gly Ala Lys Asn Leu Pro Val Arg Pro 
                485                 490                 495     


Asp Gly Thr Leu Asn Ser Phe Val Lys Gly Cys Leu Thr Leu Pro Asp 
            500                 505                 510         


Gln Gln Lys Leu Arg Leu Lys Ser Pro Val Leu Arg Lys Gln Ala Cys 
        515                 520                 525             


Pro Gln Trp Lys His Ser Phe Val Phe Ser Gly Val Thr Pro Ala Gln 
    530                 535                 540                 


Leu Arg Gln Ser Ser Leu Glu Leu Thr Val Trp Asp Gln Ala Leu Phe 
545                 550                 555                 560 


Gly Met Asn Asp Arg Leu Leu Gly Gly Thr Arg Leu Gly Ser Lys Gly 
                565                 570                 575     


Asp Thr Ala Val Gly Gly Asp Ala Cys Ser Leu Ser Lys Leu Gln Trp 
            580                 585                 590         


Gln Lys Val Leu Ser Ser Pro Asn Leu Trp Thr Asp Met Thr Leu Val 
        595                 600                 605             


Leu His 
    610 


<210>  21
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Cys Arg Thr Lys Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val Asn Gln Glu Ile Phe Ile Ala Cys Glu Gln Val 
145                 150                 155                 160 


Leu Lys Asp Gln Pro Ala Leu Val Pro His Ser Tyr Phe Ile Ala Pro 
                165                 170                 175     


Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu 
            180                 185                 190         


Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser 
        195                 200                 205             


Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr 
    210                 215                 220                 


Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr 
225                 230                 235                 240 


Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr 
                245                 250                 255     


Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile 
            260                 265                 270         


Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val 
        275                 280                 285             


Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro 
    290                 295                 300                 


Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr 
305                 310                 315                 320 


Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala 
                325                 330                 335     


Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro 
            340                 345                 350         


Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met 
        355                 360                 365             


Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe 
    370                 375                 380                 


Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp 
385                 390                 395                 400 


Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Asn Pro 
                405                 410                 415     


Arg Ser Tyr Gln Gln Trp Val His Thr Val Lys Lys Gly Gly Ala Leu 
            420                 425                 430         


Phe Asn Thr Ala Met Thr Lys Ala Thr Pro Ala Val Arg Thr Ala Tyr 
        435                 440                 445             


Lys Phe Ala Lys Asn His Ala Lys Leu Gly Leu Lys Glu Val Lys Ser 
    450                 455                 460                 


Lys Leu Lys His Lys Glu Asn Glu Glu Asp Tyr Gly Thr Cys Ser Ser 
465                 470                 475                 480 


Ser Val Gln Tyr Thr Pro Val Tyr Lys Leu His Asn Glu Lys Gly Gly 
                485                 490                 495     


Asn Ser Glu Lys Arg Lys Leu Ala Gln Ala Arg Leu Lys Arg Pro Leu 
            500                 505                 510         


Lys Ser Leu Asp Gly Ala Leu Tyr Asp Asp Glu Asp Asp Asp Asp Ile 
        515                 520                 525             


Glu Arg Ala Ser Lys Leu Ser Ser Glu Asp Gly Glu Glu Ala Ser Ala 
    530                 535                 540                 


Tyr Leu Tyr Glu Ser Asp Asp Ser Val Glu Thr Arg Val Lys Thr Pro 
545                 550                 555                 560 


Tyr Ser Gly Glu Met Asp Leu Leu Gly Glu Ile Leu Asp Thr Leu Ser 
                565                 570                 575     


Thr His Ser Ser Asp Gln Gly Lys Leu Ala Ala Ala Lys Ser Leu Asp 
            580                 585                 590         


Phe Phe Arg Ser Met Asp Asp Ile Asp Tyr Lys Pro Thr Asn Lys Ser 
        595                 600                 605             


Asn Ala Pro Ser Glu Asn Asn Leu Ala Phe Leu Cys Gly Gly Ser Gly 
    610                 615                 620                 


Asp Gln Ala Glu Trp Asn Leu Gly Gln Asp Asp Ser Ala Leu His Gly 
625                 630                 635                 640 


Lys His Leu Pro Pro Ser Pro Arg Lys Arg Val Ser Ser Ser Gly Leu 
                645                 650                 655     


Thr Asp Ser Leu Phe Ile Leu Lys Glu Glu Asn Ser Asn Lys His Leu 
            660                 665                 670         


Gly Ala Asp Asn Val Ser Asp Pro Thr Ser Gly Leu Asp Phe Gln Leu 
        675                 680                 685             


Thr Ser Pro Glu Val Ser Gln Thr Asp Lys Gly Lys Thr Glu Lys Arg 
    690                 695                 700                 


Glu Thr Leu Ser Gln Ile Ser Asp Asp Leu Leu Ile Pro Gly Leu Gly 
705                 710                 715                 720 


Arg His Ser Ser Thr Phe Val Pro Trp Glu Lys Glu Gly Lys Glu Ala 
                725                 730                 735     


Lys Glu Thr Ser Glu Asp Ile Gly Leu Leu His Glu Val Val Ser Leu 
            740                 745                 750         


Cys His Met Thr Ser Asp Phe Gln Gln Ser Leu Asn Ile Ser Asp Lys 
        755                 760                 765             


Asn Thr Asn Gly Asn Gln Thr 
    770                 775 


<210>  22
<211>  8797
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15      


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30          


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45              


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60                  


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80  


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95      


Lys Phe Leu Glu Gly Arg Lys Ile Lys Leu Val Asn Ile Asn Ser Thr 
            100                 105                 110         


Asp Ile Ala Asp Gly Arg Pro Ser Ile Val Leu Gly Leu Met Trp Thr 
        115                 120                 125             


Ile Ile Leu Tyr Phe Gln Ile Glu Glu Leu Thr Ser Asn Leu Pro Gln 
    130                 135                 140                 


Leu Gln Ser Leu Ser Ser Ser Ala Ser Ser Val Asp Ser Ile Val Ser 
145                 150                 155                 160 


Ser Glu Thr Pro Ser Pro Pro Ser Lys Arg Lys Val Thr Thr Lys Ile 
                165                 170                 175     


Gln Gly Asn Ala Lys Lys Ala Leu Leu Lys Trp Val Gln Tyr Thr Ala 
            180                 185                 190         


Gly Lys Gln Thr Gly Ile Glu Val Lys Asp Phe Gly Lys Ser Trp Arg 
        195                 200                 205             


Ser Gly Val Ala Phe His Ser Val Ile His Ala Ile Arg Pro Glu Leu 
    210                 215                 220                 


Val Asp Leu Glu Thr Val Lys Gly Arg Ser Asn Arg Glu Asn Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Thr Ile Ala Glu Thr Glu Leu Gly Ile Pro Arg Leu Leu 
                245                 250                 255     


Asp Pro Glu Asp Val Asp Val Asp Lys Pro Asp Glu Lys Ser Ile Met 
            260                 265                 270         


Thr Tyr Val Ala Gln Phe Leu Lys His Tyr Pro Asp Ile His Asn Ala 
        275                 280                 285             


Ser Thr Asp Gly Gln Glu Asp Asp Glu Ile Leu Pro Gly Phe Pro Ser 
    290                 295                 300                 


Phe Ala Asn Ser Val Gln Asn Phe Lys Arg Glu Asp Arg Val Ile Phe 
305                 310                 315                 320 


Lys Glu Met Lys Val Trp Ile Glu Gln Phe Glu Arg Asp Leu Thr Arg 
                325                 330                 335     


Ala Gln Met Val Glu Ser Asn Leu Gln Asp Lys Tyr Gln Ser Phe Lys 
            340                 345                 350         


His Phe Arg Val Gln Tyr Glu Met Lys Arg Lys Gln Ile Glu His Leu 
        355                 360                 365             


Ile Gln Pro Leu His Arg Asp Gly Lys Leu Ser Leu Asp Gln Ala Leu 
    370                 375                 380                 


Val Lys Gln Ser Trp Asp Arg Val Thr Ser Arg Leu Phe Asp Trp His 
385                 390                 395                 400 


Ile Gln Leu Asp Lys Ser Leu Pro Ala Pro Leu Gly Thr Ile Gly Ala 
                405                 410                 415     


Trp Leu Tyr Arg Ala Glu Val Ala Leu Arg Glu Glu Ile Thr Val Gln 
            420                 425                 430         


Gln Val His Glu Glu Thr Ala Asn Thr Ile Gln Arg Lys Leu Glu Gln 
        435                 440                 445             


His Lys Asp Leu Leu Gln Asn Thr Asp Ala His Lys Arg Ala Phe His 
    450                 455                 460                 


Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly Ile Pro Val Pro Pro Asp 
465                 470                 475                 480 


Gln Leu Glu Asp Met Ala Glu Arg Phe His Phe Val Ser Ser Thr Ser 
                485                 490                 495     


Glu Leu His Leu Met Lys Met Glu Phe Leu Glu Leu Lys Tyr Arg Leu 
            500                 505                 510         


Leu Ser Leu Leu Val Leu Ala Glu Ser Lys Leu Lys Ser Trp Ile Ile 
        515                 520                 525             


Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln Leu Leu Gln Asn Tyr Val 
    530                 535                 540                 


Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu Gln Tyr Glu Val Thr Tyr 
545                 550                 555                 560 


Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr Val Lys Ala Asp Gly Ser 
                565                 570                 575     


Val Glu Glu Ala Glu Asn Val Met Lys Phe Met Asn Glu Thr Thr Ala 
            580                 585                 590         


Gln Trp Arg Asn Leu Ser Val Glu Val Arg Ser Val Arg Ser Met Leu 
        595                 600                 605             


Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr Gly Asn Thr Val Ala Ser 
    610                 615                 620                 


Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys Met Leu Asn Gln Ser Glu 
625                 630                 635                 640 


Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu Pro His Trp Ile Gln Gln 
                645                 650                 655     


His Thr Ala Met Asn Asp Ala Gly Asn Phe Leu Ile Glu Thr Cys Asp 
            660                 665                 670         


Glu Met Val Ser Arg Asp Leu Lys Gln Gln Leu Leu Leu Leu Asn Gly 
        675                 680                 685             


Arg Trp Arg Glu Leu Phe Met Glu Val Lys Gln Tyr Ala Gln Ala Asp 
    690                 695                 700                 


Glu Met Asp Arg Met Lys Lys Glu Tyr Thr Asp Cys Val Val Thr Leu 
705                 710                 715                 720 


Ser Ala Phe Ala Thr Glu Ala His Lys Lys Leu Ser Glu Pro Leu Glu 
                725                 730                 735     


Val Ser Phe Met Asn Val Lys Leu Leu Ile Gln Asp Leu Glu Asp Ile 
            740                 745                 750         


Glu Gln Arg Val Pro Val Met Asp Ala Gln Tyr Lys Ile Ile Thr Lys 
        755                 760                 765             


Thr Ala His Leu Ile Thr Lys Glu Ser Pro Gln Glu Glu Gly Lys Glu 
    770                 775                 780                 


Met Phe Ala Thr Met Ser Lys Leu Lys Glu Gln Leu Thr Lys Val Lys 
785                 790                 795                 800 


Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser Gln Gln Leu Leu Ile Pro 
                805                 810                 815     


Leu Glu Glu Leu Glu Lys Gln Met Thr Ser Phe Tyr Asp Ser Leu Gly 
            820                 825                 830         


Lys Ile Asn Glu Ile Ile Thr Val Leu Glu Arg Glu Ala Gln Ser Ser 
        835                 840                 845             


Ala Leu Phe Lys Gln Lys His Gln Glu Leu Leu Ala Cys Gln Glu Asn 
    850                 855                 860                 


Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys Gly Ser Gln Ser Val Gln 
865                 870                 875                 880 


Lys Phe Val Thr Leu Ser Asn Val Leu Lys His Phe Asp Gln Thr Arg 
                885                 890                 895     


Leu Gln Arg Gln Ile Ala Asp Ile His Val Ala Phe Gln Ser Met Val 
            900                 905                 910         


Lys Lys Thr Gly Asp Trp Lys Lys His Val Glu Thr Asn Ser Arg Leu 
        915                 920                 925             


Met Lys Lys Phe Glu Glu Ser Arg Ala Glu Leu Glu Lys Val Leu Arg 
    930                 935                 940                 


Ile Ala Gln Glu Gly Leu Glu Glu Lys Gly Asp Pro Glu Glu Leu Leu 
945                 950                 955                 960 


Arg Arg His Thr Glu Phe Phe Ser Gln Leu Asp Gln Arg Val Leu Asn 
                965                 970                 975     


Ala Phe Leu Lys Ala Cys Asp Glu Leu Thr Asp Ile Leu Pro Glu Gln 
            980                 985                 990         


Glu Gln Gln Gly Leu Gln Glu Ala  Val Arg Lys Leu His  Lys Gln Trp 
        995                 1000                 1005             


Lys Asp  Leu Gln Gly Glu Ala  Pro Tyr His Leu Leu  His Leu Lys 
    1010                 1015                 1020             


Ile Asp  Val Glu Lys Asn Arg  Phe Leu Ala Ser Val  Glu Glu Cys 
    1025                 1030                 1035             


Arg Thr  Glu Leu Asp Arg Glu  Thr Lys Leu Met Pro  Gln Glu Gly 
    1040                 1045                 1050             


Ser Glu  Lys Ile Ile Lys Glu  His Arg Val Phe Phe  Ser Asp Lys 
    1055                 1060                 1065             


Gly Pro  His His Leu Cys Glu  Lys Arg Leu Gln Leu  Ile Glu Glu 
    1070                 1075                 1080             


Leu Cys  Val Lys Leu Pro Val  Arg Asp Pro Val Arg  Asp Thr Pro 
    1085                 1090                 1095             


Gly Thr  Cys His Val Thr Leu  Lys Glu Leu Arg Ala  Ala Ile Asp 
    1100                 1105                 1110             


Ser Thr  Tyr Arg Lys Leu Met  Glu Asp Pro Asp Lys  Trp Lys Asp 
    1115                 1120                 1125             


Tyr Thr  Ser Arg Phe Ser Glu  Phe Ser Ser Trp Ile  Ser Thr Asn 
    1130                 1135                 1140             


Glu Thr  Gln Leu Lys Gly Ile  Lys Gly Glu Ala Ile  Asp Thr Ala 
    1145                 1150                 1155             


Asn His  Gly Glu Val Lys Arg  Ala Val Glu Glu Ile  Arg Asn Gly 
    1160                 1165                 1170             


Val Thr  Lys Arg Gly Glu Thr  Leu Ser Trp Leu Lys  Ser Arg Leu 
    1175                 1180                 1185             


Lys Val  Leu Thr Glu Val Ser  Ser Glu Asn Glu Ala  Gln Lys Gln 
    1190                 1195                 1200             


Gly Asp  Glu Leu Ala Lys Leu  Ser Ser Ser Phe Lys  Ala Leu Val 
    1205                 1210                 1215             


Thr Leu  Leu Ser Glu Val Glu  Lys Met Leu Ser Asn  Phe Gly Asp 
    1220                 1225                 1230             


Cys Val  Gln Tyr Lys Glu Ile  Val Lys Asn Ser Leu  Glu Glu Leu 
    1235                 1240                 1245             


Ile Ser  Gly Ser Lys Glu Val  Gln Glu Gln Ala Glu  Lys Ile Leu 
    1250                 1255                 1260             


Asp Thr  Glu Asn Leu Phe Glu  Ala Gln Gln Leu Leu  Leu His His 
    1265                 1270                 1275             


Gln Gln  Lys Thr Lys Arg Ile  Ser Ala Lys Lys Arg  Asp Val Gln 
    1280                 1285                 1290             


Gln Gln  Ile Ala Gln Ala Gln  Gln Gly Glu Gly Gly  Leu Pro Asp 
    1295                 1300                 1305             


Arg Gly  His Glu Glu Leu Arg  Lys Leu Glu Ser Thr  Leu Asp Gly 
    1310                 1315                 1320             


Leu Glu  Arg Ser Arg Glu Arg  Gln Glu Arg Arg Ile  Gln Val Thr 
    1325                 1330                 1335             


Leu Arg  Lys Trp Glu Arg Phe  Glu Thr Asn Lys Glu  Thr Val Val 
    1340                 1345                 1350             


Arg Tyr  Leu Phe Gln Thr Gly  Ser Ser His Glu Arg  Phe Leu Ser 
    1355                 1360                 1365             


Phe Ser  Ser Leu Glu Ser Leu  Ser Ser Glu Leu Glu  Gln Thr Lys 
    1370                 1375                 1380             


Glu Phe  Ser Lys Arg Thr Glu  Ser Ile Ala Val Gln  Ala Glu Asn 
    1385                 1390                 1395             


Leu Val  Lys Glu Ala Ser Glu  Ile Pro Leu Gly Pro  Gln Asn Lys 
    1400                 1405                 1410             


Gln Leu  Leu Gln Gln Gln Ala  Lys Ser Ile Lys Glu  Gln Val Lys 
    1415                 1420                 1425             


Lys Leu  Glu Asp Thr Leu Glu  Glu Asp Ile Lys Thr  Met Glu Met 
    1430                 1435                 1440             


Val Lys  Thr Lys Trp Asp His  Phe Gly Ser Asn Phe  Glu Thr Leu 
    1445                 1450                 1455             


Ser Val  Trp Ile Thr Glu Lys  Glu Lys Glu Leu Asn  Ala Leu Glu 
    1460                 1465                 1470             


Thr Ser  Ser Ser Ala Met Asp  Met Gln Ile Ser Gln  Ile Lys Val 
    1475                 1480                 1485             


Thr Ile  Gln Glu Ile Glu Ser  Lys Leu Ser Ser Ile  Val Gly Leu 
    1490                 1495                 1500             


Glu Glu  Glu Ala Gln Ser Phe  Ala Gln Phe Val Thr  Thr Gly Glu 
    1505                 1510                 1515             


Ser Ala  Arg Ile Lys Ala Lys  Leu Thr Gln Ile Arg  Arg Tyr Gly 
    1520                 1525                 1530             


Glu Glu  Leu Arg Glu His Ala  Gln Cys Leu Glu Gly  Thr Ile Leu 
    1535                 1540                 1545             


Gly His  Leu Ser Gln Gln Gln  Lys Phe Glu Glu Asn  Leu Arg Lys 
    1550                 1555                 1560             


Ile Gln  Gln Ser Val Ser Glu  Phe Glu Asp Lys Leu  Ala Val Pro 
    1565                 1570                 1575             


Ile Lys  Ile Cys Ser Ser Ala  Thr Glu Thr Tyr Lys  Val Leu Gln 
    1580                 1585                 1590             


Glu His  Met Asp Leu Cys Gln  Ala Leu Glu Ser Leu  Ser Ser Ala 
    1595                 1600                 1605             


Ile Thr  Ala Phe Ser Ala Ser  Ala Arg Lys Val Val  Asn Arg Asp 
    1610                 1615                 1620             


Ser Cys  Val Gln Glu Ala Ala  Ala Leu Gln Gln Gln  Tyr Glu Asp 
    1625                 1630                 1635             


Ile Leu  Arg Arg Ala Lys Glu  Arg Gln Thr Ala Leu  Glu Asn Leu 
    1640                 1645                 1650             


Leu Ala  His Trp Gln Arg Leu  Glu Lys Glu Leu Ser  Ser Phe Leu 
    1655                 1660                 1665             


Thr Trp  Leu Glu Arg Gly Glu  Ala Lys Ala Ser Ser  Pro Glu Met 
    1670                 1675                 1680             


Asp Ile  Ser Ala Asp Arg Val  Lys Val Glu Gly Glu  Leu Gln Leu 
    1685                 1690                 1695             


Ile Gln  Ala Leu Gln Asn Glu  Val Val Ser Gln Ala  Ser Phe Tyr 
    1700                 1705                 1710             


Ser Lys  Leu Leu Gln Leu Lys  Glu Ser Leu Phe Ser  Val Ala Ser 
    1715                 1720                 1725             


Lys Asp  Asp Val Lys Met Met  Lys Leu His Leu Glu  Gln Leu Asp 
    1730                 1735                 1740             


Glu Arg  Trp Arg Asp Leu Pro  Gln Ile Ile Asn Lys  Arg Ile Asn 
    1745                 1750                 1755             


Phe Leu  Gln Ser Val Val Ala  Glu His Gln Gln Phe  Asp Glu Leu 
    1760                 1765                 1770             


Leu Leu  Ser Phe Ser Val Trp  Ile Lys Leu Phe Leu  Ser Glu Leu 
    1775                 1780                 1785             


Gln Thr  Thr Ser Glu Ile Ser  Ile Met Asp His Gln  Val Ala Leu 
    1790                 1795                 1800             


Thr Arg  His Lys Asp His Ala  Ala Glu Val Glu Ser  Lys Lys Gly 
    1805                 1810                 1815             


Glu Leu  Gln Ser Leu Gln Gly  His Leu Ala Lys Leu  Gly Ser Leu 
    1820                 1825                 1830             


Gly Arg  Ala Glu Asp Leu His  Leu Leu Gln Gly Lys  Ala Glu Asp 
    1835                 1840                 1845             


Cys Phe  Gln Leu Phe Glu Glu  Ala Ser Gln Val Val  Glu Arg Arg 
    1850                 1855                 1860             


Gln Leu  Ala Leu Ser His Leu  Ala Glu Phe Leu Gln  Ser His Ala 
    1865                 1870                 1875             


Ser Leu  Ser Gly Ile Leu Arg  Gln Leu Arg Gln Thr  Val Glu Ala 
    1880                 1885                 1890             


Thr Asn  Ser Met Asn Lys Asn  Glu Ser Asp Leu Ile  Glu Lys Asp 
    1895                 1900                 1905             


Leu Asn  Asp Ala Leu Gln Asn  Ala Lys Ala Leu Glu  Ser Ala Ala 
    1910                 1915                 1920             


Val Ser  Leu Asp Gly Ile Leu  Ser Lys Ala Gln Tyr  His Leu Lys 
    1925                 1930                 1935             


Ile Gly  Ser Ser Glu Gln Arg  Thr Ser Cys Arg Ala  Thr Ala Asp 
    1940                 1945                 1950             


Gln Leu  Cys Gly Glu Val Glu  Arg Ile Gln Asn Leu  Leu Gly Thr 
    1955                 1960                 1965             


Lys Gln  Ser Glu Ala Asp Ala  Leu Ala Val Leu Lys  Lys Ala Phe 
    1970                 1975                 1980             


Gln Asp  Gln Lys Glu Glu Leu  Leu Lys Ser Ile Glu  Asp Ile Glu 
    1985                 1990                 1995             


Glu Arg  Thr Asp Lys Glu Arg  Leu Lys Glu Pro Thr  Arg Gln Ala 
    2000                 2005                 2010             


Leu Gln  Gln Arg Leu Arg Val  Phe Asn Gln Leu Glu  Asp Glu Leu 
    2015                 2020                 2025             


Asn Ser  His Glu His Glu Leu  Cys Trp Leu Lys Asp  Lys Ala Lys 
    2030                 2035                 2040             


Gln Ile  Ala Gln Lys Asp Val  Ala Phe Ala Pro Glu  Val Asp Arg 
    2045                 2050                 2055             


Glu Ile  Asn Arg Leu Glu Val  Thr Trp Asp Asp Thr  Lys Arg Leu 
    2060                 2065                 2070             


Ile His  Glu Asn Gln Gly Gln  Cys Cys Gly Leu Ile  Asp Leu Met 
    2075                 2080                 2085             


Arg Glu  Tyr Gln Asn Leu Lys  Ser Ala Val Ser Lys  Val Leu Glu 
    2090                 2095                 2100             


Asn Ala  Ser Ser Val Ile Val  Thr Arg Thr Thr Ile  Lys Asp Gln 
    2105                 2110                 2115             


Glu Asp  Leu Lys Trp Ala Phe  Ser Lys His Glu Thr  Ala Lys Asn 
    2120                 2125                 2130             


Lys Met  Asn Tyr Lys Gln Lys  Asp Leu Asp Asn Phe  Thr Ser Lys 
    2135                 2140                 2145             


Gly Lys  His Leu Leu Ser Glu  Leu Lys Lys Ile His  Ser Ser Asp 
    2150                 2155                 2160             


Phe Ser  Leu Val Lys Thr Asp  Met Glu Ser Thr Val  Asp Lys Trp 
    2165                 2170                 2175             


Leu Asp  Val Ser Glu Lys Leu  Glu Glu Asn Met Asp  Arg Leu Arg 
    2180                 2185                 2190             


Val Ser  Leu Ser Ile Trp Asp  Asp Val Leu Ser Thr  Arg Asp Glu 
    2195                 2200                 2205             


Ile Glu  Gly Trp Ser Asn Asn  Cys Val Pro Gln Met  Ala Glu Asn 
    2210                 2215                 2220             


Ile Ser  Asn Leu Asp Asn His  Leu Arg Ala Glu Glu  Leu Leu Lys 
    2225                 2230                 2235             


Glu Phe  Glu Ser Glu Val Lys  Asn Lys Ala Leu Arg  Leu Glu Glu 
    2240                 2245                 2250             


Leu His  Ser Lys Val Asn Asp  Leu Lys Glu Leu Thr  Lys Asn Leu 
    2255                 2260                 2265             


Glu Thr  Pro Pro Asp Leu Gln  Phe Ile Glu Ala Asp  Leu Met Gln 
    2270                 2275                 2280             


Lys Leu  Glu His Ala Lys Glu  Ile Thr Glu Val Ala  Lys Gly Thr 
    2285                 2290                 2295             


Leu Lys  Asp Phe Thr Ala Gln  Ser Thr Gln Val Glu  Lys Phe Ile 
    2300                 2305                 2310             


Asn Asp  Ile Thr Thr Trp Phe  Thr Lys Val Glu Glu  Ser Leu Met 
    2315                 2320                 2325             


Asn Cys  Ala Gln Asn Glu Thr  Cys Glu Ala Leu Lys  Lys Val Lys 
    2330                 2335                 2340             


Asp Ile  Gln Lys Glu Leu Gln  Ser Gln Gln Ser Asn  Ile Ser Ser 
    2345                 2350                 2355             


Thr Gln  Glu Asn Leu Asn Ser  Leu Cys Arg Lys Tyr  His Ser Ala 
    2360                 2365                 2370             


Glu Leu  Glu Ser Leu Gly Arg  Ala Met Thr Gly Leu  Ile Lys Lys 
    2375                 2380                 2385             


His Glu  Ala Val Ser Gln Leu  Cys Ser Lys Thr Gln  Ala Ser Leu 
    2390                 2395                 2400             


Gln Glu  Ser Leu Glu Lys His  Phe Ser Glu Ser Met  Gln Glu Phe 
    2405                 2410                 2415             


Gln Glu  Trp Phe Leu Gly Ala  Lys Ala Ala Ala Lys  Glu Ser Ser 
    2420                 2425                 2430             


Asp Arg  Thr Gly Asp Ser Lys  Val Leu Glu Ala Lys  Leu His Asp 
    2435                 2440                 2445             


Leu Gln  Asn Ile Leu Asp Ser  Val Ser Asp Gly Gln  Ser Lys Leu 
    2450                 2455                 2460             


Asp Ala  Val Thr Gln Glu Gly  Gln Thr Leu Tyr Ala  His Leu Ser 
    2465                 2470                 2475             


Lys Gln  Ile Val Ser Ser Ile  Gln Glu Gln Ile Thr  Lys Ala Asn 
    2480                 2485                 2490             


Glu Glu  Phe Gln Ala Phe Leu  Lys Gln Cys Leu Lys  Asp Lys Gln 
    2495                 2500                 2505             


Ala Leu  Gln Asp Cys Ala Ser  Glu Leu Gly Ser Phe  Glu Asp Gln 
    2510                 2515                 2520             


His Arg  Lys Leu Asn Leu Trp  Ile His Glu Met Glu  Glu Arg Phe 
    2525                 2530                 2535             


Asn Thr  Glu Asn Leu Gly Glu  Ser Lys Gln His Ile  Pro Glu Lys 
    2540                 2545                 2550             


Lys Asn  Glu Val His Lys Val  Glu Met Phe Leu Gly  Glu Leu Leu 
    2555                 2560                 2565             


Ala Ala  Arg Glu Ser Leu Asp  Lys Leu Ser Gln Arg  Gly Gln Leu 
    2570                 2575                 2580             


Leu Ser  Glu Glu Gly His Gly  Ala Gly Gln Glu Gly  Arg Leu Cys 
    2585                 2590                 2595             


Ser Gln  Leu Leu Thr Ser His  Gln Asn Leu Leu Arg  Met Thr Lys 
    2600                 2605                 2610             


Glu Lys  Leu Arg Ser Cys Gln  Val Ala Leu Gln Glu  His Glu Ala 
    2615                 2620                 2625             


Leu Glu  Glu Ala Leu Gln Ser  Met Trp Phe Trp Val  Lys Ala Ile 
    2630                 2635                 2640             


Gln Asp  Arg Leu Ala Cys Ala  Glu Ser Thr Leu Gly  Ser Lys Asp 
    2645                 2650                 2655             


Thr Leu  Glu Lys Arg Leu Ser  Gln Ile Gln Asp Ile  Leu Leu Met 
    2660                 2665                 2670             


Lys Gly  Glu Gly Glu Val Lys  Leu Asn Met Ala Ile  Gly Lys Gly 
    2675                 2680                 2685             


Glu Gln  Ala Leu Arg Ser Ser  Asn Lys Glu Gly Gln  Arg Val Ile 
    2690                 2695                 2700             


Gln Thr  Gln Leu Glu Thr Leu  Lys Glu Val Trp Ala  Asp Ile Met 
    2705                 2710                 2715             


Ser Ser  Ser Val His Ala Gln  Ser Thr Leu Glu Ser  Val Ile Ser 
    2720                 2725                 2730             


Gln Trp  Asn Asp Tyr Val Glu  Arg Lys Asn Gln Leu  Glu Gln Trp 
    2735                 2740                 2745             


Met Glu  Ser Val Asp Gln Lys  Ile Glu His Pro Leu  Gln Pro Gln 
    2750                 2755                 2760             


Pro Gly  Leu Lys Glu Lys Phe  Val Leu Leu Asp His  Leu Gln Ser 
    2765                 2770                 2775             


Ile Leu  Ser Glu Ala Glu Asp  His Thr Arg Ala Leu  His Arg Leu 
    2780                 2785                 2790             


Ile Ala  Lys Ser Arg Glu Leu  Tyr Glu Lys Thr Glu  Asp Glu Ser 
    2795                 2800                 2805             


Phe Lys  Asp Thr Ala Gln Glu  Glu Leu Lys Thr Gln  Phe Asn Asp 
    2810                 2815                 2820             


Ile Met  Thr Val Ala Lys Glu  Lys Met Arg Lys Val  Glu Glu Ile 
    2825                 2830                 2835             


Val Lys  Asp His Leu Met Tyr  Leu Asp Ala Val His  Glu Phe Thr 
    2840                 2845                 2850             


Asp Trp  Leu His Ser Ala Lys  Glu Glu Leu His Arg  Trp Ser Asp 
    2855                 2860                 2865             


Met Ser  Gly Asp Ser Ser Ala  Thr Gln Lys Lys Leu  Ser Lys Ile 
    2870                 2875                 2880             


Lys Glu  Leu Ile Asp Ser Arg  Glu Ile Gly Ala Ser  Arg Leu Ser 
    2885                 2890                 2895             


Arg Val  Glu Ser Leu Ala Pro  Glu Val Lys Gln Asn  Thr Thr Ala 
    2900                 2905                 2910             


Ser Gly  Cys Glu Leu Met His  Thr Glu Met Gln Ala  Leu Arg Ala 
    2915                 2920                 2925             


Asp Trp  Lys Gln Trp Glu Asp  Ser Val Phe Gln Thr  Gln Ser Cys 
    2930                 2935                 2940             


Leu Glu  Asn Leu Val Ser Gln  Met Ala Leu Ser Glu  Gln Glu Phe 
    2945                 2950                 2955             


Ser Gly  Gln Val Ala Gln Leu  Glu Gln Ala Leu Glu  Gln Phe Ser 
    2960                 2965                 2970             


Ala Leu  Leu Lys Thr Trp Ala  Gln Gln Leu Thr Leu  Leu Glu Gly 
    2975                 2980                 2985             


Lys Asn  Thr Asp Glu Glu Ile  Val Glu Cys Trp His  Lys Gly Gln 
    2990                 2995                 3000             


Glu Ile  Leu Asp Ala Leu Gln  Lys Ala Glu Pro Arg  Thr Glu Asp 
    3005                 3010                 3015             


Leu Lys  Ser Gln Leu Asn Glu  Leu Cys Arg Phe Ser  Arg Asp Leu 
    3020                 3025                 3030             


Ser Thr  Tyr Ser Gly Lys Val  Ser Gly Leu Ile Lys  Glu Tyr Asn 
    3035                 3040                 3045             


Cys Leu  Cys Leu Gln Ala Ser  Lys Gly Cys Gln Asn  Lys Glu Gln 
    3050                 3055                 3060             


Ile Leu  Gln Gln Arg Phe Arg  Lys Ala Phe Arg Asp  Phe Gln Gln 
    3065                 3070                 3075             


Trp Leu  Val Asn Ala Lys Ile  Thr Thr Ala Lys Cys  Phe Asp Ile 
    3080                 3085                 3090             


Pro Gln  Asn Ile Ser Glu Val  Ser Thr Ser Leu Gln  Lys Ile Gln 
    3095                 3100                 3105             


Glu Phe  Leu Ser Glu Ser Glu  Asn Gly Gln His Lys  Leu Asn Met 
    3110                 3115                 3120             


Met Leu  Ser Lys Gly Glu Leu  Leu Ser Thr Leu Leu  Thr Lys Glu 
    3125                 3130                 3135             


Lys Ala  Lys Gly Ile Gln Ala  Lys Val Thr Ala Ala  Lys Glu Asp 
    3140                 3145                 3150             


Trp Lys  Asn Phe His Ser Asn  Leu His Gln Lys Glu  Ser Ala Leu 
    3155                 3160                 3165             


Glu Asn  Leu Lys Ile Gln Met  Lys Asp Phe Glu Val  Ser Ala Glu 
    3170                 3175                 3180             


Pro Ile  Gln Asp Trp Leu Ser  Lys Thr Glu Lys Met  Val His Glu 
    3185                 3190                 3195             


Ser Ser  Asn Arg Leu Tyr Asp  Leu Pro Ala Lys Arg  Arg Glu Gln 
    3200                 3205                 3210             


Gln Lys  Leu Gln Ser Val Leu  Glu Glu Ile His Cys  Tyr Glu Pro 
    3215                 3220                 3225             


Gln Leu  Asn Arg Leu Lys Glu  Lys Ala Gln Gln Leu  Trp Glu Gly 
    3230                 3235                 3240             


Gln Ala  Ala Ser Lys Ser Phe  Arg His Arg Val Ser  Gln Leu Ser 
    3245                 3250                 3255             


Ser Gln  Tyr Leu Ala Leu Ser  Asn Leu Thr Lys Glu  Lys Val Ser 
    3260                 3265                 3270             


Arg Leu  Asp Arg Ile Val Ala  Glu His Asn Gln Phe  Ser Leu Gly 
    3275                 3280                 3285             


Ile Lys  Glu Leu Gln Asp Trp  Met Thr Asp Ala Ile  His Met Leu 
    3290                 3295                 3300             


Asp Ser  Tyr Cys His Pro Thr  Ser Asp Lys Ser Val  Leu Asp Ser 
    3305                 3310                 3315             


Arg Thr  Leu Lys Leu Glu Ala  Leu Leu Ser Val Lys  Gln Glu Lys 
    3320                 3325                 3330             


Glu Ile  Gln Met Lys Met Ile  Val Thr Arg Gly Glu  Ser Val Leu 
    3335                 3340                 3345             


Gln Asn  Thr Ser Pro Glu Gly  Ile Pro Thr Ile Gln  Gln Gln Leu 
    3350                 3355                 3360             


Gln Ser  Val Lys Asp Met Trp  Ala Ser Leu Leu Ser  Ala Gly Ile 
    3365                 3370                 3375             


Arg Cys  Lys Ser Gln Leu Glu  Gly Ala Leu Ser Lys  Trp Thr Ser 
    3380                 3385                 3390             


Tyr Gln  Asp Gly Val Arg Gln  Phe Ser Gly Trp Met  Asp Ser Met 
    3395                 3400                 3405             


Glu Ala  Asn Leu Asn Glu Ser  Glu Arg Gln His Ala  Glu Leu Arg 
    3410                 3415                 3420             


Asp Lys  Thr Thr Met Leu Gly  Lys Ala Lys Leu Leu  Asn Glu Glu 
    3425                 3430                 3435             


Val Leu  Ser Tyr Ser Ser Leu  Leu Glu Thr Ile Glu  Val Lys Gly 
    3440                 3445                 3450             


Ala Gly  Met Thr Glu His Tyr  Val Thr Gln Leu Glu  Leu Gln Asp 
    3455                 3460                 3465             


Leu Gln  Glu Arg Tyr Arg Ala  Ile Gln Glu Arg Ala  Lys Glu Ala 
    3470                 3475                 3480             


Val Thr  Lys Ser Glu Lys Leu  Val Arg Leu His Gln  Glu Tyr Gln 
    3485                 3490                 3495             


Arg Asp  Leu Lys Ala Phe Glu  Val Trp Leu Gly Gln  Glu Gln Glu 
    3500                 3505                 3510             


Lys Leu  Asp Gln Tyr Ser Val  Leu Glu Gly Asp Ala  His Thr His 
    3515                 3520                 3525             


Glu Thr  Thr Leu Arg Asp Leu  Gln Glu Leu Gln Val  His Cys Ala 
    3530                 3535                 3540             


Glu Gly  Gln Ala Leu Leu Asn  Ser Val Leu His Thr  Arg Glu Asp 
    3545                 3550                 3555             


Val Ile  Pro Ser Gly Ile Pro  Gln Ala Glu Asp Arg  Ala Leu Glu 
    3560                 3565                 3570             


Ser Leu  Arg Gln Asp Trp Gln  Ala Tyr Gln His Arg  Leu Ser Glu 
    3575                 3580                 3585             


Thr Arg  Thr Gln Phe Asn Asn  Val Val Asn Lys Leu  Arg Leu Met 
    3590                 3595                 3600             


Glu Gln  Lys Phe Gln Gln Val  Asp Glu Trp Leu Lys  Thr Ala Glu 
    3605                 3610                 3615             


Glu Lys  Val Ser Pro Arg Thr  Arg Arg Gln Ser Asn  Arg Ala Thr 
    3620                 3625                 3630             


Lys Glu  Ile Gln Leu His Gln  Met Lys Lys Trp His  Glu Glu Val 
    3635                 3640                 3645             


Thr Ala  Tyr Arg Asp Glu Val  Glu Glu Val Gly Ala  Arg Ala Gln 
    3650                 3655                 3660             


Glu Ile  Leu Asp Glu Ser His  Val Asn Ser Arg Met  Gly Cys Gln 
    3665                 3670                 3675             


Ala Thr  Gln Leu Thr Ser Arg  Tyr Gln Ala Leu Leu  Leu Gln Val 
    3680                 3685                 3690             


Leu Glu  Gln Ile Lys Phe Leu  Glu Glu Glu Ile Gln  Ser Leu Glu 
    3695                 3700                 3705             


Glu Ser  Glu Ser Ser Leu Ser  Ser Tyr Ser Asp Trp  Tyr Gly Ser 
    3710                 3715                 3720             


Thr His  Lys Asn Phe Lys Asn  Val Ala Thr Lys Ile  Asp Lys Val 
    3725                 3730                 3735             


Asp Thr  Val Met Met Gly Lys  Lys Leu Lys Thr Leu  Glu Val Leu 
    3740                 3745                 3750             


Leu Lys  Asp Met Glu Lys Gly  His Ser Leu Leu Lys  Ser Ala Arg 
    3755                 3760                 3765             


Glu Lys  Gly Glu Arg Ala Val  Lys Tyr Leu Glu Glu  Gly Glu Ala 
    3770                 3775                 3780             


Glu Arg  Leu Arg Lys Glu Ile  His Asp His Met Glu  Gln Leu Lys 
    3785                 3790                 3795             


Glu Leu  Thr Ser Thr Val Arg  Lys Glu His Met Thr  Leu Glu Lys 
    3800                 3805                 3810             


Gly Leu  His Leu Ala Lys Glu  Phe Ser Asp Lys Cys  Lys Ala Leu 
    3815                 3820                 3825             


Thr Gln  Trp Ile Ala Glu Tyr  Gln Glu Ile Leu His  Val Pro Glu 
    3830                 3835                 3840             


Glu Pro  Lys Met Glu Leu Tyr  Glu Lys Lys Ala Gln  Leu Ser Lys 
    3845                 3850                 3855             


Tyr Lys  Ser Leu Gln Gln Thr  Val Leu Ser His Glu  Pro Ser Val 
    3860                 3865                 3870             


Lys Ser  Val Arg Glu Lys Gly  Glu Ala Leu Leu Glu  Leu Val Gln 
    3875                 3880                 3885             


Asp Val  Thr Leu Lys Asp Lys  Ile Asp Gln Leu Gln  Ser Asp Tyr 
    3890                 3895                 3900             


Gln Asp  Leu Cys Ser Ile Gly  Lys Glu His Val Phe  Ser Leu Glu 
    3905                 3910                 3915             


Ala Lys  Val Lys Asp His Glu  Asp Tyr Asn Ser Glu  Leu Gln Glu 
    3920                 3925                 3930             


Val Glu  Lys Trp Leu Leu Gln  Met Ser Gly Arg Leu  Val Ala Pro 
    3935                 3940                 3945             


Asp Leu  Leu Glu Thr Ser Ser  Leu Glu Thr Ile Thr  Gln Gln Leu 
    3950                 3955                 3960             


Ala His  His Lys Ala Met Met  Glu Glu Ile Ala Gly  Phe Glu Asp 
    3965                 3970                 3975             


Arg Leu  Asn Asn Leu Gln Met  Lys Gly Asp Thr Leu  Ile Gly Gln 
    3980                 3985                 3990             


Cys Ala  Asp His Leu Gln Ala  Lys Leu Lys Gln Asn  Val His Ala 
    3995                 4000                 4005             


His Leu  Gln Gly Thr Lys Asp  Ser Tyr Ser Ala Ile  Cys Ser Thr 
    4010                 4015                 4020             


Ala Gln  Arg Met Tyr Gln Ser  Leu Glu His Glu Leu  Gln Lys His 
    4025                 4030                 4035             


Val Ser  Arg Gln Asp Thr Leu  Gln Gln Cys Gln Ala  Trp Leu Ser 
    4040                 4045                 4050             


Ala Val  Gln Pro Asp Leu Glu  Pro Ser Pro Gln Pro  Pro Leu Ser 
    4055                 4060                 4065             


Arg Ala  Glu Ala Ile Lys Gln  Val Lys His Phe Arg  Ala Leu Gln 
    4070                 4075                 4080             


Glu Gln  Ala Arg Thr Tyr Leu  Asp Leu Leu Cys Ser  Met Cys Asp 
    4085                 4090                 4095             


Leu Ser  Asn Ala Ser Val Lys  Thr Thr Ala Lys Asp  Ile Gln Gln 
    4100                 4105                 4110             


Thr Glu  Gln Thr Ile Glu Gln  Lys Leu Val Gln Ala  Gln Asn Leu 
    4115                 4120                 4125             


Thr Gln  Gly Trp Glu Glu Ile  Lys His Leu Lys Ser  Glu Leu Trp 
    4130                 4135                 4140             


Ile Tyr  Leu Gln Asp Ala Asp  Gln Gln Leu Gln Asn  Met Lys Arg 
    4145                 4150                 4155             


Arg His  Ser Glu Leu Glu Leu  Asn Ile Ala Gln Asn  Met Val Ser 
    4160                 4165                 4170             


Gln Val  Lys Asp Phe Val Lys  Lys Leu Gln Ser Lys  Gln Ala Ser 
    4175                 4180                 4185             


Val Asn  Thr Ile Ile Glu Lys  Val Asn Lys Leu Thr  Lys Lys Glu 
    4190                 4195                 4200             


Glu Ser  Pro Glu His Lys Glu  Ile Asn His Leu Asn  Asp Gln Trp 
    4205                 4210                 4215             


Leu Asp  Leu Cys Arg Gln Ser  Asn Asn Leu Cys Leu  Gln Arg Glu 
    4220                 4225                 4230             


Glu Asp  Leu Gln Arg Thr Arg  Asp Tyr His Asp Cys  Met Asn Val 
    4235                 4240                 4245             


Val Glu  Val Phe Leu Glu Lys  Phe Thr Thr Glu Trp  Asp Asn Leu 
    4250                 4255                 4260             


Ala Arg  Ser Asp Ala Glu Ser  Thr Ala Val His Leu  Glu Ala Leu 
    4265                 4270                 4275             


Lys Lys  Leu Ala Leu Ala Leu  Gln Glu Arg Lys Tyr  Ala Ile Glu 
    4280                 4285                 4290             


Asp Leu  Lys Asp Gln Lys Gln  Lys Met Ile Glu His  Leu Asn Leu 
    4295                 4300                 4305             


Asp Asp  Lys Glu Leu Val Lys  Glu Gln Thr Ser His  Leu Glu Gln 
    4310                 4315                 4320             


Arg Trp  Phe Gln Leu Glu Asp  Leu Ile Lys Arg Lys  Ile Gln Val 
    4325                 4330                 4335             


Ser Val  Thr Asn Leu Glu Glu  Leu Asn Val Val Gln  Ser Arg Phe 
    4340                 4345                 4350             


Gln Glu  Leu Met Glu Trp Ala  Glu Glu Gln Gln Pro  Asn Ile Ala 
    4355                 4360                 4365             


Glu Ala  Leu Lys Gln Ser Pro  Pro Pro Asp Met Ala  Gln Asn Leu 
    4370                 4375                 4380             


Leu Met  Asp His Leu Ala Ile  Cys Ser Glu Leu Glu  Ala Lys Gln 
    4385                 4390                 4395             


Met Leu  Leu Lys Ser Leu Ile  Lys Asp Ala Asp Arg  Val Met Ala 
    4400                 4405                 4410             


Asp Leu  Gly Leu Asn Glu Arg  Gln Val Ile Gln Lys  Ala Leu Ser 
    4415                 4420                 4425             


Asp Ala  Gln Ser His Val Asn  Cys Leu Ser Asp Leu  Val Gly Gln 
    4430                 4435                 4440             


Arg Arg  Lys Tyr Leu Asn Lys  Ala Leu Ser Glu Lys  Thr Gln Phe 
    4445                 4450                 4455             


Leu Met  Ala Val Phe Gln Ala  Thr Ser Gln Ile Gln  Gln His Glu 
    4460                 4465                 4470             


Arg Lys  Ile Met Phe Arg Glu  His Ile Cys Leu Leu  Pro Asp Asp 
    4475                 4480                 4485             


Val Ser  Lys Gln Val Lys Thr  Cys Lys Ser Ala Gln  Ala Ser Leu 
    4490                 4495                 4500             


Lys Thr  Tyr Gln Asn Glu Val  Thr Gly Leu Trp Ala  Gln Gly Arg 
    4505                 4510                 4515             


Glu Leu  Met Lys Glu Val Thr  Glu Gln Glu Lys Ser  Glu Val Leu 
    4520                 4525                 4530             


Gly Lys  Leu Gln Glu Leu Gln  Ser Val Tyr Asp Ser  Val Leu Gln 
    4535                 4540                 4545             


Lys Cys  Ser His Arg Leu Gln  Glu Leu Glu Lys Asn  Leu Val Ser 
    4550                 4555                 4560             


Arg Lys  His Phe Lys Glu Asp  Phe Asp Lys Ala Cys  His Trp Leu 
    4565                 4570                 4575             


Lys Gln  Ala Asp Ile Val Thr  Phe Pro Glu Ile Asn  Leu Met Asn 
    4580                 4585                 4590             


Glu Ser  Ser Glu Leu His Thr  Gln Leu Ala Lys Tyr  Gln Asn Ile 
    4595                 4600                 4605             


Leu Glu  Gln Ser Pro Glu Tyr  Glu Asn Leu Leu Leu  Thr Leu Gln 
    4610                 4615                 4620             


Arg Thr  Gly Gln Thr Ile Leu  Pro Ser Leu Asn Glu  Val Asp His 
    4625                 4630                 4635             


Ser Tyr  Leu Ser Glu Lys Leu  Asn Ala Leu Pro Arg  Gln Phe Asn 
    4640                 4645                 4650             


Val Ile  Val Ala Leu Ala Lys  Asp Lys Phe Tyr Lys  Val Gln Glu 
    4655                 4660                 4665             


Ala Ile  Leu Ala Arg Lys Glu  Tyr Ala Ser Leu Ile  Glu Leu Thr 
    4670                 4675                 4680             


Thr Gln  Ser Leu Ser Glu Leu  Glu Ala Gln Phe Leu  Arg Met Ser 
    4685                 4690                 4695             


Lys Val  Pro Thr Asp Leu Ala  Val Glu Glu Ala Leu  Ser Leu Gln 
    4700                 4705                 4710             


Asp Gly  Cys Arg Ala Ile Leu  Asp Glu Val Ala Gly  Leu Gly Glu 
    4715                 4720                 4725             


Ala Val  Asp Glu Leu Asn Gln  Lys Lys Glu Gly Phe  Arg Ser Thr 
    4730                 4735                 4740             


Gly Gln  Pro Trp Gln Pro Asp  Lys Met Leu His Leu  Val Thr Leu 
    4745                 4750                 4755             


Tyr His  Arg Leu Lys Arg Gln  Thr Glu Gln Arg Val  Ser Leu Leu 
    4760                 4765                 4770             


Glu Asp  Thr Thr Ser Ala Tyr  Gln Glu His Glu Lys  Met Cys Gln 
    4775                 4780                 4785             


Gln Leu  Glu Arg Gln Leu Lys  Ser Val Lys Glu Glu  Gln Ser Lys 
    4790                 4795                 4800             


Val Asn  Glu Glu Thr Leu Pro  Ala Glu Glu Lys Leu  Lys Met Tyr 
    4805                 4810                 4815             


His Ser  Leu Ala Gly Ser Leu  Gln Asp Ser Gly Ile  Val Leu Lys 
    4820                 4825                 4830             


Arg Val  Thr Ile His Leu Glu  Asp Leu Ala Pro His  Leu Asp Pro 
    4835                 4840                 4845             


Leu Ala  Tyr Glu Lys Ala Arg  His Gln Ile Gln Ser  Trp Gln Gly 
    4850                 4855                 4860             


Glu Leu  Lys Leu Leu Thr Ser  Ala Ile Gly Glu Thr  Val Thr Glu 
    4865                 4870                 4875             


Cys Glu  Ser Arg Met Val Gln  Ser Ile Asp Phe Gln  Thr Glu Met 
    4880                 4885                 4890             


Ser Arg  Ser Leu Asp Trp Leu  Arg Arg Val Lys Ala  Glu Leu Ser 
    4895                 4900                 4905             


Gly Pro  Val Tyr Leu Asp Leu  Asn Leu Gln Asp Ile  Gln Glu Glu 
    4910                 4915                 4920             


Ile Arg  Lys Ile Gln Ile His  Gln Glu Glu Val Gln  Ser Ser Leu 
    4925                 4930                 4935             


Arg Ile  Met Asn Ala Leu Ser  His Lys Glu Lys Glu  Lys Phe Thr 
    4940                 4945                 4950             


Lys Ala  Lys Glu Leu Ile Ser  Ala Asp Leu Glu His  Ser Leu Ala 
    4955                 4960                 4965             


Glu Leu  Ser Glu Leu Asp Gly  Asp Ile Gln Glu Ala  Leu Arg Thr 
    4970                 4975                 4980             


Arg Gln  Ala Thr Leu Thr Glu  Ile Tyr Ser Gln Cys  Gln Arg Tyr 
    4985                 4990                 4995             


Tyr Gln  Val Phe Gln Ala Ala  Asn Asp Trp Leu Glu  Asp Ala Gln 
    5000                 5005                 5010             


Glu Leu  Leu Gln Leu Ala Gly  Asn Gly Leu Asp Val  Glu Ser Ala 
    5015                 5020                 5025             


Glu Glu  Asn Leu Lys Ser His  Met Glu Phe Phe Ser  Thr Glu Asp 
    5030                 5035                 5040             


Gln Phe  His Ser Asn Leu Glu  Glu Leu His Ser Leu  Val Ala Thr 
    5045                 5050                 5055             


Leu Asp  Pro Leu Ile Lys Pro  Thr Gly Lys Glu Asp  Leu Glu Gln 
    5060                 5065                 5070             


Lys Val  Ala Ser Leu Glu Leu  Arg Ser Gln Arg Met  Ser Arg Asp 
    5075                 5080                 5085             


Ser Gly  Ala Gln Val Asp Leu  Leu Gln Arg Cys Thr  Ala Gln Trp 
    5090                 5095                 5100             


His Asp  Tyr Gln Lys Ala Arg  Glu Glu Val Ile Glu  Leu Met Asn 
    5105                 5110                 5115             


Asp Thr  Glu Lys Lys Leu Ser  Glu Phe Ser Leu Leu  Lys Thr Ser 
    5120                 5125                 5130             


Ser Ser  His Glu Ala Glu Glu  Lys Leu Ser Glu His  Lys Ala Leu 
    5135                 5140                 5145             


Val Ser  Val Val Asn Ser Phe  His Glu Lys Ile Val  Ala Leu Glu 
    5150                 5155                 5160             


Glu Lys  Ala Ser Gln Leu Glu  Lys Thr Gly Asn Asp  Ala Ser Lys 
    5165                 5170                 5175             


Ala Thr  Leu Ser Arg Ser Met  Thr Thr Val Trp Gln  Arg Trp Thr 
    5180                 5185                 5190             


Arg Leu  Arg Ala Val Ala Gln  Asp Gln Glu Lys Ile  Leu Glu Asp 
    5195                 5200                 5205             


Ala Val  Asp Glu Trp Thr Gly  Phe Asn Asn Lys Val  Lys Lys Ala 
    5210                 5215                 5220             


Thr Glu  Met Ile Asp Gln Leu  Gln Asp Lys Leu Pro  Gly Ser Ser 
    5225                 5230                 5235             


Ala Glu  Lys Ala Ser Lys Ala  Glu Leu Leu Thr Leu  Leu Glu Tyr 
    5240                 5245                 5250             


His Asp  Thr Phe Val Leu Glu  Leu Glu Gln Gln Gln  Ser Ala Leu 
    5255                 5260                 5265             


Gly Met  Leu Arg Gln Gln Thr  Leu Ser Met Leu Gln  Asp Gly Ala 
    5270                 5275                 5280             


Ala Pro  Thr Pro Gly Glu Glu  Pro Pro Leu Met Gln  Glu Ile Thr 
    5285                 5290                 5295             


Ala Met  Gln Asp Arg Cys Leu  Asn Met Gln Glu Lys  Val Lys Thr 
    5300                 5305                 5310             


Asn Gly  Lys Leu Val Lys Gln  Glu Leu Lys Asp Arg  Glu Met Val 
    5315                 5320                 5325             


Glu Thr  Gln Ile Asn Ser Val  Lys Cys Trp Val Gln  Glu Thr Lys 
    5330                 5335                 5340             


Glu Tyr  Leu Gly Asn Pro Thr  Ile Glu Ile Asp Ala  Gln Leu Glu 
    5345                 5350                 5355             


Glu Leu  Gln Ile Leu Leu Thr  Glu Ala Thr Asn His  Arg Gln Asn 
    5360                 5365                 5370             


Ile Glu  Lys Met Ala Glu Glu  Gln Lys Glu Lys Tyr  Leu Gly Leu 
    5375                 5380                 5385             


Tyr Thr  Ile Leu Pro Ser Glu  Leu Ser Leu Gln Leu  Ala Glu Val 
    5390                 5395                 5400             


Ala Leu  Asp Leu Lys Ile Arg  Asp Gln Ile Gln Asp  Lys Ile Lys 
    5405                 5410                 5415             


Glu Val  Glu Gln Ser Lys Ala  Thr Ser Gln Glu Leu  Ser Arg Gln 
    5420                 5425                 5430             


Ile Gln  Lys Leu Ala Lys Asp  Leu Thr Thr Ile Leu  Thr Lys Leu 
    5435                 5440                 5445             


Lys Ala  Lys Thr Asp Asn Val  Val Gln Ala Lys Thr  Asp Gln Lys 
    5450                 5455                 5460             


Val Leu  Gly Glu Glu Leu Asp  Gly Cys Asn Ser Lys  Leu Met Glu 
    5465                 5470                 5475             


Leu Asp  Ala Ala Val Gln Lys  Phe Leu Glu Gln Asn  Gly Gln Leu 
    5480                 5485                 5490             


Gly Lys  Pro Leu Ala Lys Lys  Ile Gly Lys Leu Thr  Glu Leu His 
    5495                 5500                 5505             


Gln Gln  Thr Ile Arg Gln Ala  Glu Asn Arg Leu Ser  Lys Leu Asn 
    5510                 5515                 5520             


Gln Ala  Ala Ser His Leu Glu  Glu Tyr Asn Glu Met  Leu Glu Leu 
    5525                 5530                 5535             


Ile Leu  Lys Trp Ile Glu Lys  Ala Lys Val Leu Ala  His Gly Thr 
    5540                 5545                 5550             


Ile Ala  Trp Asn Ser Ala Ser  Gln Leu Arg Glu Gln  Tyr Ile Leu 
    5555                 5560                 5565             


His Gln  Thr Leu Leu Glu Glu  Ser Lys Glu Ile Asp  Ser Glu Leu 
    5570                 5575                 5580             


Glu Ala  Met Thr Glu Lys Leu  Gln Tyr Leu Thr Ser  Val Tyr Cys 
    5585                 5590                 5595             


Thr Glu  Lys Met Ser Gln Gln  Val Ala Glu Leu Gly  Arg Glu Thr 
    5600                 5605                 5610             


Glu Glu  Leu Arg Gln Met Ile  Lys Ile Arg Leu Gln  Asn Leu Gln 
    5615                 5620                 5625             


Asp Ala  Ala Lys Asp Met Lys  Lys Phe Glu Ala Glu  Leu Lys Lys 
    5630                 5635                 5640             


Leu Gln  Ala Ala Leu Glu Gln  Ala Gln Ala Thr Leu  Thr Ser Pro 
    5645                 5650                 5655             


Glu Val  Gly Arg Leu Ser Leu  Lys Glu Gln Leu Ser  His Arg Gln 
    5660                 5665                 5670             


His Leu  Leu Ser Glu Met Glu  Ser Leu Lys Pro Lys  Val Gln Ala 
    5675                 5680                 5685             


Val Gln  Leu Cys Gln Ser Ala  Leu Arg Ile Pro Glu  Asp Val Val 
    5690                 5695                 5700             


Ala Ser  Leu Pro Leu Cys His  Ala Ala Leu Arg Leu  Gln Glu Glu 
    5705                 5710                 5715             


Ala Ser  Arg Leu Gln His Thr  Ala Ile Gln Gln Cys  Asn Ile Met 
    5720                 5725                 5730             


Gln Glu  Ala Val Val Gln Tyr  Glu Gln Tyr Glu Gln  Glu Met Lys 
    5735                 5740                 5745             


His Leu  Gln Gln Leu Ile Glu  Gly Ala His Arg Glu  Ile Glu Asp 
    5750                 5755                 5760             


Lys Pro  Val Ala Thr Ser Asn  Ile Gln Glu Leu Gln  Ala Gln Ile 
    5765                 5770                 5775             


Ser Arg  His Glu Glu Leu Ala  Gln Lys Ile Lys Gly  Tyr Gln Glu 
    5780                 5785                 5790             


Gln Ile  Ala Ser Leu Asn Ser  Lys Cys Lys Met Leu  Thr Met Lys 
    5795                 5800                 5805             


Ala Lys  His Ala Thr Met Leu  Leu Thr Val Thr Glu  Val Glu Gly 
    5810                 5815                 5820             


Leu Ala  Glu Gly Thr Glu Asp  Leu Asp Gly Glu Leu  Leu Pro Thr 
    5825                 5830                 5835             


Pro Ser  Ala His Pro Ser Val  Val Met Met Thr Ala  Gly Arg Cys 
    5840                 5845                 5850             


His Thr  Leu Leu Ser Pro Val  Thr Glu Glu Ser Gly  Glu Glu Gly 
    5855                 5860                 5865             


Thr Asn  Ser Glu Ile Ser Ser  Pro Pro Ala Cys Arg  Ser Pro Ser 
    5870                 5875                 5880             


Pro Val  Ala Asn Thr Asp Ala  Ser Val Asn Gln Asp  Ile Ala Tyr 
    5885                 5890                 5895             


Tyr Gln  Ala Leu Ser Ala Glu  Arg Leu Gln Thr Asp  Ala Ala Lys 
    5900                 5905                 5910             


Ile His  Pro Ser Thr Ser Ala  Ser Gln Glu Phe Tyr  Glu Pro Gly 
    5915                 5920                 5925             


Leu Glu  Pro Ser Ala Thr Ala  Lys Leu Gly Asp Leu  Gln Arg Ser 
    5930                 5935                 5940             


Trp Glu  Thr Leu Lys Asn Val  Ile Ser Glu Lys Gln  Arg Thr Leu 
    5945                 5950                 5955             


Tyr Glu  Ala Leu Glu Arg Gln  Gln Lys Tyr Gln Asp  Ser Leu Gln 
    5960                 5965                 5970             


Ser Ile  Ser Thr Lys Met Glu  Ala Ile Glu Leu Lys  Leu Ser Glu 
    5975                 5980                 5985             


Ser Pro  Glu Pro Gly Arg Ser  Pro Glu Ser Gln Met  Ala Glu His 
    5990                 5995                 6000             


Gln Ala  Leu Met Asp Glu Ile  Leu Met Leu Gln Asp  Glu Ile Asn 
    6005                 6010                 6015             


Glu Leu  Gln Ser Ser Leu Ala  Glu Glu Leu Val Ser  Glu Ser Cys 
    6020                 6025                 6030             


Glu Ala  Asp Pro Ala Glu Gln  Leu Ala Leu Gln Ser  Thr Leu Thr 
    6035                 6040                 6045             


Val Leu  Ala Glu Arg Met Ser  Thr Ile Arg Met Lys  Ala Ser Gly 
    6050                 6055                 6060             


Lys Arg  Gln Leu Leu Glu Glu  Lys Leu Asn Asp Gln  Leu Glu Glu 
    6065                 6070                 6075             


Gln Arg  Gln Glu Gln Ala Leu  Gln Arg Tyr Arg Cys  Glu Ala Asp 
    6080                 6085                 6090             


Glu Leu  Asp Ser Trp Leu Leu  Ser Thr Lys Ala Thr  Leu Asp Thr 
    6095                 6100                 6105             


Ala Leu  Ser Pro Pro Lys Glu  Pro Met Asp Met Glu  Ala Gln Leu 
    6110                 6115                 6120             


Met Asp  Cys Gln Asn Met Leu  Val Glu Ile Glu Gln  Lys Val Val 
    6125                 6130                 6135             


Ala Leu  Ser Glu Leu Ser Val  His Asn Glu Asn Leu  Leu Leu Glu 
    6140                 6145                 6150             


Gly Lys  Ala His Thr Lys Asp  Glu Ala Glu Gln Leu  Ala Gly Lys 
    6155                 6160                 6165             


Leu Arg  Arg Leu Lys Gly Ser  Leu Leu Glu Leu Gln  Arg Ala Leu 
    6170                 6175                 6180             


His Asp  Lys Gln Leu Asn Met  Gln Gly Thr Ala Gln  Glu Lys Glu 
    6185                 6190                 6195             


Glu Ser  Asp Val Asp Leu Thr  Ala Thr Gln Ser Pro  Gly Val Gln 
    6200                 6205                 6210             


Glu Trp  Leu Ala Gln Ala Arg  Thr Thr Trp Thr Gln  Gln Arg Gln 
    6215                 6220                 6225             


Ser Ser  Leu Gln Gln Gln Lys  Glu Leu Glu Gln Glu  Leu Ala Glu 
    6230                 6235                 6240             


Gln Lys  Ser Leu Leu Arg Ser  Val Ala Ser Arg Gly  Glu Glu Ile 
    6245                 6250                 6255             


Leu Ile  Gln His Ser Ala Ala  Glu Thr Ser Gly Asp  Ala Gly Glu 
    6260                 6265                 6270             


Lys Pro  Asp Val Leu Ser Gln  Glu Leu Gly Met Glu  Gly Glu Lys 
    6275                 6280                 6285             


Ser Ser  Ala Glu Asp Gln Met  Arg Met Lys Trp Glu  Ser Leu His 
    6290                 6295                 6300             


Gln Glu  Phe Ser Thr Lys Gln  Lys Leu Leu Gln Asn  Val Leu Glu 
    6305                 6310                 6315             


Gln Glu  Gln Glu Gln Val Leu  Tyr Ser Arg Pro Asn  Arg Leu Leu 
    6320                 6325                 6330             


Ser Gly  Val Pro Leu Tyr Lys  Gly Asp Val Pro Thr  Gln Asp Lys 
    6335                 6340                 6345             


Ser Ala  Val Thr Ser Leu Leu  Asp Gly Leu Asn Gln  Ala Phe Glu 
    6350                 6355                 6360             


Glu Val  Ser Ser Gln Ser Gly  Gly Ala Lys Arg Gln  Ser Ile His 
    6365                 6370                 6375             


Leu Glu  Gln Lys Leu Tyr Asp  Gly Val Ser Ala Thr  Ser Thr Trp 
    6380                 6385                 6390             


Leu Asp  Asp Val Glu Glu Arg  Leu Phe Val Ala Thr  Ala Leu Leu 
    6395                 6400                 6405             


Pro Glu  Glu Thr Glu Thr Cys  Leu Phe Asn Gln Glu  Ile Leu Ala 
    6410                 6415                 6420             


Lys Asp  Ile Lys Glu Met Ser  Glu Glu Met Asp Lys  Asn Lys Asn 
    6425                 6430                 6435             


Leu Phe  Ser Gln Ala Phe Pro  Glu Asn Gly Asp Asn  Arg Asp Val 
    6440                 6445                 6450             


Ile Glu  Asp Thr Leu Gly Cys  Leu Leu Gly Arg Leu  Ser Leu Leu 
    6455                 6460                 6465             


Asp Ser  Val Val Asn Gln Arg  Cys His Gln Met Lys  Glu Arg Leu 
    6470                 6475                 6480             


Gln Gln  Ile Leu Asn Phe Gln  Asn Asp Leu Lys Val  Leu Phe Thr 
    6485                 6490                 6495             


Ser Leu  Ala Asp Asn Lys Tyr  Ile Ile Leu Gln Lys  Leu Ala Asn 
    6500                 6505                 6510             


Val Phe  Glu Gln Pro Val Ala  Glu Gln Ile Glu Ala  Ile Gln Gln 
    6515                 6520                 6525             


Ala Glu  Asp Gly Leu Lys Glu  Phe Asp Ala Gly Ile  Ile Glu Leu 
    6530                 6535                 6540             


Lys Arg  Arg Gly Asp Lys Leu  Gln Val Glu Gln Pro  Ser Met Gln 
    6545                 6550                 6555             


Glu Leu  Ser Lys Leu Gln Asp  Met Tyr Asp Glu Leu  Met Met Ile 
    6560                 6565                 6570             


Ile Gly  Ser Arg Arg Ser Gly  Leu Asn Gln Asn Leu  Thr Leu Lys 
    6575                 6580                 6585             


Ser Gln  Tyr Glu Arg Ala Leu  Gln Asp Leu Ala Asp  Leu Leu Glu 
    6590                 6595                 6600             


Thr Gly  Gln Glu Lys Met Ala  Gly Asp Gln Lys Ile  Ile Val Ser 
    6605                 6610                 6615             


Ser Lys  Glu Glu Ile Gln Gln  Leu Leu Asp Lys His  Lys Glu Tyr 
    6620                 6625                 6630             


Phe Gln  Gly Leu Glu Ser His  Met Ile Leu Thr Glu  Thr Leu Phe 
    6635                 6640                 6645             


Arg Lys  Ile Ile Ser Phe Ala  Val Gln Lys Glu Thr  Gln Phe His 
    6650                 6655                 6660             


Thr Glu  Leu Met Ala Gln Ala  Ser Ala Val Leu Lys  Arg Ala His 
    6665                 6670                 6675             


Lys Arg  Gly Val Glu Leu Glu  Tyr Ile Leu Glu Thr  Trp Ser His 
    6680                 6685                 6690             


Leu Asp  Glu Asp Gln Gln Glu  Leu Ser Arg Gln Leu  Glu Val Val 
    6695                 6700                 6705             


Glu Ser  Ser Ile Pro Ser Val  Gly Leu Val Glu Glu  Asn Glu Asp 
    6710                 6715                 6720             


Arg Leu  Ile Asp Arg Ile Thr  Leu Tyr Gln His Leu  Lys Ser Ser 
    6725                 6730                 6735             


Leu Asn  Glu Tyr Gln Pro Lys  Leu Tyr Gln Val Leu  Asp Asp Gly 
    6740                 6745                 6750             


Lys Arg  Leu Leu Ile Ser Ile  Ser Cys Ser Asp Leu  Glu Ser Gln 
    6755                 6760                 6765             


Leu Asn  Gln Leu Gly Glu Cys  Trp Leu Ser Asn Thr  Asn Lys Met 
    6770                 6775                 6780             


Ser Lys  Glu Leu His Arg Leu  Glu Thr Ile Leu Lys  His Trp Thr 
    6785                 6790                 6795             


Arg Tyr  Gln Ser Glu Ser Ala  Asp Leu Ile His Trp  Leu Gln Ser 
    6800                 6805                 6810             


Ala Lys  Asp Arg Leu Glu Phe  Trp Thr Gln Gln Ser  Val Thr Val 
    6815                 6820                 6825             


Pro Gln  Glu Leu Glu Met Val  Arg Asp His Leu Asn  Ala Phe Leu 
    6830                 6835                 6840             


Glu Phe  Ser Lys Glu Val Asp  Ala Gln Ser Ser Leu  Lys Ser Ser 
    6845                 6850                 6855             


Val Leu  Ser Thr Gly Asn Gln  Leu Leu Arg Leu Lys  Lys Val Asp 
    6860                 6865                 6870             


Thr Ala  Thr Leu Arg Ser Glu  Leu Ser Arg Ile Asp  Ser Gln Trp 
    6875                 6880                 6885             


Thr Asp  Leu Leu Thr Asn Ile  Pro Ala Val Gln Glu  Lys Leu His 
    6890                 6895                 6900             


Gln Leu  Gln Met Asp Lys Leu  Pro Ser Arg His Ala  Ile Ser Glu 
    6905                 6910                 6915             


Val Met  Ser Trp Ile Ser Leu  Met Glu Asn Val Ile  Gln Lys Asp 
    6920                 6925                 6930             


Glu Asp  Asn Ile Lys Asn Ser  Ile Gly Tyr Lys Ala  Ile His Glu 
    6935                 6940                 6945             


Tyr Leu  Gln Lys Tyr Lys Gly  Phe Lys Ile Asp Ile  Asn Cys Lys 
    6950                 6955                 6960             


Gln Leu  Thr Val Asp Phe Val  Asn Gln Ser Val Leu  Gln Ile Ser 
    6965                 6970                 6975             


Ser Gln  Asp Val Glu Ser Lys  Arg Ser Asp Lys Thr  Asp Phe Ala 
    6980                 6985                 6990             


Glu Gln  Leu Gly Ala Met Asn  Lys Ser Trp Gln Ile  Leu Gln Gly 
    6995                 7000                 7005             


Leu Val  Thr Glu Lys Ile Gln  Leu Leu Glu Gly Leu  Leu Glu Ser 
    7010                 7015                 7020             


Trp Ser  Glu Tyr Glu Asn Asn  Val Gln Cys Leu Lys  Thr Trp Phe 
    7025                 7030                 7035             


Glu Thr  Gln Glu Lys Arg Leu  Lys Gln Gln His Arg  Ile Gly Asp 
    7040                 7045                 7050             


Gln Ala  Ser Val Gln Asn Ala  Leu Lys Asp Cys Gln  Asp Leu Glu 
    7055                 7060                 7065             


Asp Leu  Ile Lys Ala Lys Glu  Lys Glu Val Glu Lys  Ile Glu Gln 
    7070                 7075                 7080             


Asn Gly  Leu Ala Leu Ile Gln  Asn Lys Lys Glu Asp  Val Ser Ser 
    7085                 7090                 7095             


Ile Val  Met Ser Thr Leu Arg  Glu Leu Gly Gln Thr  Trp Ala Asn 
    7100                 7105                 7110             


Leu Asp  His Met Val Gly Gln  Leu Lys Ile Leu Leu  Lys Ser Val 
    7115                 7120                 7125             


Leu Asp  Gln Trp Ser Ser His  Lys Val Ala Phe Asp  Lys Ile Asn 
    7130                 7135                 7140             


Ser Tyr  Leu Met Glu Ala Arg  Tyr Ser Leu Ser Arg  Phe Arg Leu 
    7145                 7150                 7155             


Leu Thr  Gly Ser Leu Glu Ala  Val Gln Val Gln Val  Asp Asn Leu 
    7160                 7165                 7170             


Gln Asn  Leu Gln Asp Asp Leu  Glu Lys Gln Glu Arg  Ser Leu Gln 
    7175                 7180                 7185             


Lys Phe  Gly Ser Ile Thr Asn  Gln Leu Leu Lys Glu  Cys His Pro 
    7190                 7195                 7200             


Pro Val  Thr Glu Thr Leu Thr  Asn Thr Leu Lys Glu  Val Asn Met 
    7205                 7210                 7215             


Arg Trp  Asn Asn Leu Leu Glu  Glu Ile Ala Glu Gln  Leu Gln Ser 
    7220                 7225                 7230             


Ser Lys  Ala Leu Leu Gln Leu  Trp Gln Arg Tyr Lys  Asp Tyr Ser 
    7235                 7240                 7245             


Lys Gln  Cys Ala Ser Thr Val  Gln Gln Gln Glu Asp  Arg Thr Asn 
    7250                 7255                 7260             


Glu Leu  Leu Lys Ala Ala Thr  Asn Lys Asp Ile Ala  Asp Asp Glu 
    7265                 7270                 7275             


Val Ala  Thr Trp Ile Gln Asp  Cys Asn Asp Leu Leu  Lys Gly Leu 
    7280                 7285                 7290             


Gly Thr  Val Lys Asp Ser Leu  Phe Phe Leu His Glu  Leu Gly Glu 
    7295                 7300                 7305             


Gln Leu  Lys Gln Gln Val Asp  Ala Ser Ala Ala Ser  Ala Ile Gln 
    7310                 7315                 7320             


Ser Asp  Gln Leu Ser Leu Ser  Gln His Leu Cys Ala  Leu Glu Gln 
    7325                 7330                 7335             


Ala Leu  Cys Lys Gln Gln Thr  Ser Leu Gln Ala Gly  Val Leu Asp 
    7340                 7345                 7350             


Tyr Glu  Thr Phe Ala Lys Ser  Leu Glu Ala Leu Glu  Ala Trp Ile 
    7355                 7360                 7365             


Val Glu  Ala Glu Glu Ile Leu  Gln Gly Gln Asp Pro  Ser His Ser 
    7370                 7375                 7380             


Ser Asp  Leu Ser Thr Ile Gln  Glu Arg Met Glu Glu  Leu Lys Gly 
    7385                 7390                 7395             


Gln Met  Leu Lys Phe Ser Ser  Met Ala Pro Asp Leu  Asp Arg Leu 
    7400                 7405                 7410             


Asn Glu  Leu Gly Tyr Arg Leu  Pro Leu Asn Asp Lys  Glu Ile Lys 
    7415                 7420                 7425             


Arg Met  Gln Asn Leu Asn Arg  His Trp Ser Leu Ile  Ser Ser Gln 
    7430                 7435                 7440             


Thr Thr  Glu Arg Phe Ser Lys  Leu Gln Ser Phe Leu  Leu Gln His 
    7445                 7450                 7455             


Gln Thr  Phe Leu Glu Lys Cys  Glu Thr Trp Met Glu  Phe Leu Val 
    7460                 7465                 7470             


Gln Thr  Glu Gln Lys Leu Ala  Val Glu Ile Ser Gly  Asn Tyr Gln 
    7475                 7480                 7485             


His Leu  Leu Glu Gln Gln Arg  Ala His Glu Leu Phe  Gln Ala Glu 
    7490                 7495                 7500             


Met Phe  Ser Arg Gln Gln Ile  Leu His Ser Ile Ile  Ile Asp Gly 
    7505                 7510                 7515             


Gln Arg  Leu Leu Glu Gln Gly  Gln Val Asp Asp Arg  Asp Glu Phe 
    7520                 7525                 7530             


Asn Leu  Lys Leu Thr Leu Leu  Ser Asn Gln Trp Gln  Gly Val Ile 
    7535                 7540                 7545             


Arg Arg  Ala Gln Gln Arg Arg  Gly Ile Ile Asp Ser  Gln Ile Arg 
    7550                 7555                 7560             


Gln Trp  Gln Arg Tyr Arg Glu  Met Ala Glu Lys Leu  Arg Lys Trp 
    7565                 7570                 7575             


Leu Val  Glu Val Ser Tyr Leu  Pro Met Ser Gly Leu  Gly Ser Val 
    7580                 7585                 7590             


Pro Ile  Pro Leu Gln Gln Ala  Arg Thr Leu Phe Asp  Glu Val Gln 
    7595                 7600                 7605             


Phe Lys  Glu Lys Val Phe Leu  Arg Gln Gln Gly Ser  Tyr Ile Leu 
    7610                 7615                 7620             


Thr Val  Glu Ala Gly Lys Gln  Leu Leu Leu Ser Ala  Asp Ser Gly 
    7625                 7630                 7635             


Ala Glu  Ala Ala Leu Gln Ala  Glu Leu Ala Glu Ile  Gln Glu Lys 
    7640                 7645                 7650             


Trp Lys  Ser Ala Ser Met Arg  Leu Glu Glu Gln Lys  Lys Lys Leu 
    7655                 7660                 7665             


Ala Phe  Leu Leu Lys Asp Trp  Glu Lys Cys Glu Lys  Gly Ile Ala 
    7670                 7675                 7680             


Asp Ser  Leu Glu Lys Leu Arg  Thr Phe Lys Lys Lys  Leu Ser Gln 
    7685                 7690                 7695             


Ser Leu  Pro Asp His His Glu  Glu Leu His Ala Glu  Gln Met Arg 
    7700                 7705                 7710             


Cys Lys  Glu Leu Glu Asn Ala  Val Gly Ser Trp Thr  Asp Asp Leu 
    7715                 7720                 7725             


Thr Gln  Leu Ser Leu Leu Lys  Asp Thr Leu Ser Ala  Tyr Ile Ser 
    7730                 7735                 7740             


Ala Asp  Asp Ile Ser Ile Leu  Asn Glu Arg Val Glu  Leu Leu Gln 
    7745                 7750                 7755             


Arg Gln  Trp Glu Glu Leu Cys  His Gln Leu Ser Leu  Arg Arg Gln 
    7760                 7765                 7770             


Gln Ile  Gly Glu Arg Leu Asn  Glu Trp Ala Val Phe  Ser Glu Lys 
    7775                 7780                 7785             


Asn Lys  Glu Leu Cys Glu Trp  Leu Thr Gln Met Glu  Ser Lys Val 
    7790                 7795                 7800             


Ser Gln  Asn Gly Asp Ile Leu  Ile Glu Glu Met Ile  Glu Lys Leu 
    7805                 7810                 7815             


Lys Lys  Asp Tyr Gln Glu Glu  Ile Ala Ile Ala Gln  Glu Asn Lys 
    7820                 7825                 7830             


Ile Gln  Leu Gln Gln Met Gly  Glu Arg Leu Ala Lys  Ala Ser His 
    7835                 7840                 7845             


Glu Ser  Lys Ala Ser Glu Ile  Glu Tyr Lys Leu Gly  Lys Val Asn 
    7850                 7855                 7860             


Asp Arg  Trp Gln His Leu Leu  Asp Leu Ile Ala Ala  Arg Val Lys 
    7865                 7870                 7875             


Lys Leu  Lys Glu Thr Leu Val  Ala Val Gln Gln Leu  Asp Lys Asn 
    7880                 7885                 7890             


Met Ser  Ser Leu Arg Thr Trp  Leu Ala His Ile Glu  Ser Glu Leu 
    7895                 7900                 7905             


Ala Lys  Pro Ile Val Tyr Asp  Ser Cys Asn Ser Glu  Glu Ile Gln 
    7910                 7915                 7920             


Arg Lys  Leu Asn Glu Gln Gln  Glu Leu Gln Arg Asp  Ile Glu Lys 
    7925                 7930                 7935             


His Ser  Thr Gly Val Ala Ser  Val Leu Asn Leu Cys  Glu Val Leu 
    7940                 7945                 7950             


Leu His  Asp Cys Asp Ala Cys  Ala Thr Asp Ala Glu  Cys Asp Ser 
    7955                 7960                 7965             


Ile Gln  Gln Ala Thr Arg Asn  Leu Asp Arg Arg Trp  Arg Asn Ile 
    7970                 7975                 7980             


Cys Ala  Met Ser Met Glu Arg  Arg Leu Lys Ile Glu  Glu Thr Trp 
    7985                 7990                 7995             


Arg Leu  Trp Gln Lys Phe Leu  Asp Asp Tyr Ser Arg  Phe Glu Asp 
    8000                 8005                 8010             


Trp Leu  Lys Ser Ser Glu Arg  Thr Ala Ala Phe Pro  Ser Ser Ser 
    8015                 8020                 8025             


Gly Val  Ile Tyr Thr Val Ala  Lys Glu Glu Leu Lys  Lys Phe Glu 
    8030                 8035                 8040             


Ala Phe  Gln Arg Gln Val His  Glu Cys Leu Thr Gln  Leu Glu Leu 
    8045                 8050                 8055             


Ile Asn  Lys Gln Tyr Arg Arg  Leu Ala Arg Glu Asn  Arg Thr Asp 
    8060                 8065                 8070             


Ser Ala  Cys Ser Leu Lys Gln  Met Val His Glu Gly  Asn Gln Arg 
    8075                 8080                 8085             


Trp Asp  Asn Leu Gln Lys Arg  Val Thr Ser Ile Leu  Arg Arg Leu 
    8090                 8095                 8100             


Lys His  Phe Ile Gly Gln Arg  Glu Glu Phe Glu Thr  Ala Arg Asp 
    8105                 8110                 8115             


Ser Ile  Leu Val Trp Leu Thr  Glu Met Asp Leu Gln  Leu Thr Asn 
    8120                 8125                 8130             


Ile Glu  His Phe Ser Glu Cys  Asp Val Gln Ala Lys  Ile Lys Gln 
    8135                 8140                 8145             


Leu Lys  Ala Phe Gln Gln Glu  Ile Ser Leu Asn His  Asn Lys Ile 
    8150                 8155                 8160             


Glu Gln  Ile Ile Ala Gln Gly  Glu Gln Leu Ile Glu  Lys Ser Glu 
    8165                 8170                 8175             


Pro Leu  Asp Ala Ala Ile Ile  Glu Glu Glu Leu Asp  Glu Leu Arg 
    8180                 8185                 8190             


Arg Tyr  Cys Gln Glu Val Phe  Gly Arg Val Glu Arg  Tyr His Lys 
    8195                 8200                 8205             


Lys Leu  Ile Arg Leu Pro Leu  Pro Asp Asp Glu His  Asp Leu Ser 
    8210                 8215                 8220             


Asp Arg  Glu Leu Glu Leu Glu  Asp Ser Ala Ala Leu  Ser Asp Leu 
    8225                 8230                 8235             


His Trp  His Asp Arg Ser Ala  Asp Ser Leu Leu Ser  Pro Gln Pro 
    8240                 8245                 8250             


Ser Ser  Asn Leu Ser Leu Ser  Leu Ala Gln Pro Leu  Arg Ser Glu 
    8255                 8260                 8265             


Arg Ser  Gly Arg Asp Thr Pro  Ala Ser Val Asp Ser  Ile Pro Leu 
    8270                 8275                 8280             


Glu Trp  Asp His Asp Tyr Asp  Leu Ser Arg Asp Leu  Glu Ser Ala 
    8285                 8290                 8295             


Met Ser  Arg Ala Leu Pro Ser  Glu Asp Glu Glu Gly  Gln Asp Asp 
    8300                 8305                 8310             


Lys Asp  Phe Tyr Leu Arg Gly  Ala Val Gly Leu Ser  Gly Asp His 
    8315                 8320                 8325             


Ser Ala  Leu Glu Ser Gln Ile  Arg Gln Leu Gly Lys  Ala Leu Asp 
    8330                 8335                 8340             


Asp Ser  Arg Phe Gln Ile Gln  Gln Thr Glu Asn Ile  Ile Arg Ser 
    8345                 8350                 8355             


Lys Thr  Pro Thr Gly Pro Glu  Leu Asp Thr Ser Tyr  Lys Gly Tyr 
    8360                 8365                 8370             


Met Lys  Leu Leu Gly Glu Cys  Ser Ser Ser Ile Asp  Ser Val Lys 
    8375                 8380                 8385             


Arg Leu  Glu His Lys Leu Lys  Glu Glu Glu Glu Ser  Leu Pro Gly 
    8390                 8395                 8400             


Phe Val  Asn Leu His Ser Thr  Glu Thr Gln Thr Ala  Gly Val Ile 
    8405                 8410                 8415             


Asp Arg  Trp Glu Leu Leu Gln  Ala Gln Ala Leu Ser  Lys Glu Leu 
    8420                 8425                 8430             


Arg Met  Lys Gln Asn Leu Gln  Lys Trp Gln Gln Phe  Asn Ser Asp 
    8435                 8440                 8445             


Leu Asn  Ser Ile Trp Ala Trp  Leu Gly Asp Thr Glu  Glu Glu Leu 
    8450                 8455                 8460             


Glu Gln  Leu Gln Arg Leu Glu  Leu Ser Thr Asp Ile  Gln Thr Ile 
    8465                 8470                 8475             


Glu Leu  Gln Ile Lys Lys Leu  Lys Glu Leu Gln Lys  Ala Val Asp 
    8480                 8485                 8490             


His Arg  Lys Ala Ile Ile Leu  Ser Ile Asn Leu Cys  Ser Pro Glu 
    8495                 8500                 8505             


Phe Thr  Gln Ala Asp Ser Lys  Glu Ser Arg Asp Leu  Gln Asp Arg 
    8510                 8515                 8520             


Leu Ser  Gln Met Asn Gly Arg  Trp Asp Arg Val Cys  Ser Leu Leu 
    8525                 8530                 8535             


Glu Glu  Trp Arg Gly Leu Leu  Gln Asp Ala Leu Met  Gln Cys Gln 
    8540                 8545                 8550             


Gly Phe  His Glu Met Ser His  Gly Leu Leu Leu Met  Leu Glu Asn 
    8555                 8560                 8565             


Ile Asp  Arg Arg Lys Asn Glu  Ile Val Pro Ile Asp  Ser Asn Leu 
    8570                 8575                 8580             


Asp Ala  Glu Ile Leu Gln Asp  His His Lys Gln Leu  Met Gln Ile 
    8585                 8590                 8595             


Lys His  Glu Leu Leu Glu Ser  Gln Leu Arg Val Ala  Ser Leu Gln 
    8600                 8605                 8610             


Asp Met  Ser Cys Gln Leu Leu  Val Asn Ala Glu Gly  Thr Asp Cys 
    8615                 8620                 8625             


Leu Glu  Ala Lys Glu Lys Val  His Val Ile Gly Asn  Arg Leu Lys 
    8630                 8635                 8640             


Leu Leu  Leu Lys Glu Val Ser  Arg His Ile Lys Glu  Leu Glu Lys 
    8645                 8650                 8655             


Leu Leu  Asp Val Ser Ser Ser  Gln Gln Asp Leu Ser  Ser Trp Ser 
    8660                 8665                 8670             


Ser Ala  Asp Glu Leu Asp Thr  Ser Gly Ser Val Ser  Pro Thr Ser 
    8675                 8680                 8685             


Gly Arg  Ser Thr Pro Asn Arg  Gln Lys Thr Pro Arg  Gly Lys Cys 
    8690                 8695                 8700             


Ser Leu  Ser Gln Pro Gly Pro  Ser Val Ser Ser Pro  His Ser Arg 
    8705                 8710                 8715             


Ser Thr  Lys Gly Gly Ser Asp  Ser Ser Leu Ser Glu  Pro Gly Pro 
    8720                 8725                 8730             


Gly Arg  Ser Gly Arg Gly Phe  Leu Phe Arg Val Leu  Arg Ala Ala 
    8735                 8740                 8745             


Leu Pro  Leu Gln Leu Leu Leu  Leu Leu Leu Ile Gly  Leu Ala Cys 
    8750                 8755                 8760             


Leu Val  Pro Met Ser Glu Glu  Asp Tyr Ser Cys Ala  Leu Ser Asn 
    8765                 8770                 8775             


Asn Phe  Ala Arg Ser Phe His  Pro Met Leu Arg Tyr  Thr Asn Gly 
    8780                 8785                 8790             


Pro Pro  Pro Leu 
    8795         


<210>  23
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Arg Leu Arg Arg Leu Ala His Leu Val Leu Phe Cys Pro Phe 
1               5                   10                  15      


Ser Lys Arg Leu Gln Gly Arg Leu Pro Gly Leu Arg Val Arg Cys Ile 
            20                  25                  30          


Phe Leu Ala Trp Leu Gly Val Phe Ala Gly Ser Trp Leu Val Tyr Val 
        35                  40                  45              


His Tyr Ser Ser Tyr Ser Glu Arg Cys Arg Gly His Val Cys Gln Val 
    50                  55                  60                  


Val Ile Cys Asp Gln Tyr Arg Lys Gly Ile Ile Ser Gly Ser Val Cys 
65                  70                  75                  80  


Gln Asp Leu Cys Glu Leu His Met Val Glu Trp Arg Thr Cys Leu Ser 
                85                  90                  95      


Val Ala Pro Gly Gln Gln Val Tyr Ser Gly Leu Trp Arg Asp Lys Asp 
            100                 105                 110         


Val Thr Ile Lys Cys Gly Ile Glu Glu Thr Leu Asp Ser Lys Ala Arg 
        115                 120                 125             


Ser Asp Ala Ala Pro Arg Arg Glu Leu Val Leu Phe Asp Lys Pro Thr 
    130                 135                 140                 


Arg Gly Thr Ser Ile Lys Glu Phe Arg Glu Met Thr Leu Ser Phe Leu 
145                 150                 155                 160 


Lys Ala Asn Leu Gly Asp Leu Pro Ser Leu Pro Ala Leu Val Gly Gln 
                165                 170                 175     


Val Leu Leu Met Ala Asp Phe Asn Lys Asp Asn Arg Val Ser Leu Ala 
            180                 185                 190         


Glu Ala Lys Ser Val Trp Ala Leu Leu Gln Arg Asn Glu Phe Leu Leu 
        195                 200                 205             


Leu Leu Ser Leu Gln Glu Lys Glu His Ala Ser Arg Leu Leu Gly Tyr 
    210                 215                 220                 


Cys Gly Asp Leu Tyr Leu Thr Glu Gly Val Pro His Gly Ala Trp His 
225                 230                 235                 240 


Ala Ala Ala Leu Pro Pro Leu Leu Arg Pro Leu Leu Pro Pro Ala Leu 
                245                 250                 255     


Gln Gly Ala Leu Gln Gln Trp Leu Gly Pro Ala Trp Pro Trp Arg Ala 
            260                 265                 270         


Lys Ile Ala Ile Gly Leu Leu Glu Phe Val Glu Glu Leu Phe His Gly 
        275                 280                 285             


Ser Tyr Gly Thr Phe Tyr Met Cys Glu Thr Thr Leu Ala Asn Val Gly 
    290                 295                 300                 


Tyr Thr Ala Thr Tyr Asp Phe Lys Met Ala Asp Leu Gln Gln Val Ala 
305                 310                 315                 320 


Pro Glu Ala Thr Val Arg Arg Phe Leu Gln Gly Arg Arg Cys Glu His 
                325                 330                 335     


Ser Thr Asp Cys Thr Tyr Gly Arg Asp Cys Arg Ala Pro Cys Asp Arg 
            340                 345                 350         


Leu Met Arg Gln Cys Lys Gly Asp Leu Ile Gln Pro Asn Leu Ala Lys 
        355                 360                 365             


Val Cys Ala Leu Leu Arg Gly Tyr Leu Leu Pro Gly Ala Pro Ala Asp 
    370                 375                 380                 


Leu Arg Glu Glu Leu Gly Thr Gln Leu Arg Thr Cys Thr Thr Leu Ser 
385                 390                 395                 400 


Gly Leu Ala Ser Gln Val Glu Ala His His Ser Leu Val Leu Ser His 
                405                 410                 415     


Leu Lys Thr Leu Leu Trp Lys Lys Ile Ser Asn Thr Lys Tyr Ser 
            420                 425                 430     


<210>  24
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg Asn Trp Cys Ser Tyr Val Val Thr Arg Thr Ile Ser Cys His 
        35                  40                  45              


Val Gln Asn Gly Thr Tyr Leu Gln Arg Val Leu Gln Asn Cys Pro Trp 
    50                  55                  60                  


Pro Met Ser Cys Pro Gly Ser Ser Tyr Arg Thr Val Val Arg Pro Thr 
65                  70                  75                  80  


Tyr Lys Val Met Tyr Lys Ile Val Thr Ala Arg Glu Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly His Ser Gly Val Ser Cys Glu Glu Ala Ser Ser Ala Ser Leu 
            100                 105                 110         


Glu Pro Met Trp Ser Gly Ser Thr Met Arg Arg Met Ala Leu Arg Pro 
        115                 120                 125             


Thr Ala Phe Ser Gly Cys Leu Asn Cys Ser Lys Val Ser Glu Leu Thr 
    130                 135                 140                 


Glu Arg Leu Lys Val Leu Glu Ala Lys Met Thr Met Leu Thr Val Ile 
145                 150                 155                 160 


Glu Gln Pro Val Pro Pro Thr Pro Ala Thr Pro Glu Asp Pro Ala Pro 
                165                 170                 175     


Leu Trp Gly Pro Pro Pro Ala Gln Gly Ser Pro Gly Asp Gly Gly Leu 
            180                 185                 190         


Gln Asp Gln Val Gly Ala Trp Gly Leu Pro Gly Pro Thr Gly Pro Lys 
        195                 200                 205             


Gly Asp Ala Gly Ser Arg Gly Pro Met Gly Met Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Gln Gly Pro Pro Gly Ser Pro Gly Arg Ala Gly Ala Val Gly Thr 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Pro Ala Pro Val Gly Pro Pro His Ala Arg Ile Ser Gln His 
            260                 265                 270         


Gly Asp Pro Leu Leu Ser Asn Thr Phe Thr Glu Thr Asn Asn His Trp 
        275                 280                 285             


Pro Gln Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Met Gly Pro 
    290                 295                 300                 


Pro Gly Pro Pro Gly Pro Thr Gly Val Pro Gly Ser Pro Gly His Ile 
305                 310                 315                 320 


Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Ile Ser Gly His Pro Gly 
                325                 330                 335     


Glu Lys Gly Glu Arg Gly Leu Arg Gly Glu Pro Gly Pro Gln Gly Ser 
            340                 345                 350         


Ala Gly Gln Arg Gly Glu Pro Gly Pro Lys Gly Asp Pro Gly Glu Lys 
        355                 360                 365             


Ser His Trp Gly Glu Gly Leu His Gln Leu Arg Glu Ala Leu Lys Ile 
    370                 375                 380                 


Leu Ala Glu Arg Val Leu Ile Leu Glu Thr Met Ile Gly Leu Tyr Glu 
385                 390                 395                 400 


Pro Glu Leu Gly Ser Gly Ala Gly Pro Ala Gly Thr Gly Thr Pro Ser 
                405                 410                 415     


Leu Leu Arg Gly Lys Arg Gly Gly His Ala Thr Asn Tyr Arg Ile Val 
            420                 425                 430         


Ala Pro Arg Ser Arg Asp Glu Arg Gly 
        435                 440     


<210>  25
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Glu Ser Trp Glu Ala Ala Pro Gly Gly Gln Ala Gly Ala Glu 
1               5                   10                  15      


Leu Pro Met Glu Pro Val Gly Ser Leu Val Pro Thr Leu Glu Gln Pro 
            20                  25                  30          


Gln Val Pro Ala Lys Val Arg Gln Pro Glu Gly Pro Glu Ser Ser Pro 
        35                  40                  45              


Ser Pro Ala Gly Ala Val Glu Lys Ala Ala Gly Ala Gly Leu Glu Pro 
    50                  55                  60                  


Ser Ser Lys Lys Lys Pro Pro Ser Pro Arg Pro Gly Ser Pro Arg Val 
65                  70                  75                  80  


Pro Pro Leu Ser Leu Gly Tyr Gly Val Cys Pro Glu Pro Pro Ser Pro 
                85                  90                  95      


Gly Pro Ala Leu Val Lys Leu Pro Arg Asn Gly Glu Ala Pro Gly Ala 
            100                 105                 110         


Glu Pro Ala Pro Ser Ala Trp Ala Pro Met Glu Leu Gln Val Asp Val 
        115                 120                 125             


Arg Val Lys Pro Val Gly Ala Ala Gly Gly Ser Ser Thr Pro Ser Pro 
    130                 135                 140                 


Arg Pro Ser Thr Arg Phe Leu Lys Val Pro Val Pro Glu Ser Pro Ala 
145                 150                 155                 160 


Phe Ser Arg His Ala Asp Pro Ala His Gln Leu Leu Leu Arg Ala Pro 
                165                 170                 175     


Ser Gln Gly Gly Thr Trp Gly Arg Arg Ser Pro Leu Ala Ala Ala Arg 
            180                 185                 190         


Thr Glu Ser Gly Cys Asp Ala Glu Gly Arg Ala Ser Pro Ala Glu Gly 
        195                 200                 205             


Ser Ala Gly Ser Pro Gly Ser Pro Thr Cys Cys Arg Cys Lys Glu Leu 
    210                 215                 220                 


Gly Leu Glu Lys Glu Asp Ala Ala Leu Leu Pro Arg Ala Gly Leu Asp 
225                 230                 235                 240 


Gly Asp Glu Lys Leu Pro Arg Ala Val Thr Leu Thr Gly Leu Pro Met 
                245                 250                 255     


Tyr Val Lys Ser Leu Tyr Trp Ala Leu Ala Phe Met Ala Val Leu Leu 
            260                 265                 270         


Ala Val Ser Gly Val Val Ile Val Val Leu Ala Ser Arg Ala Gly Ala 
        275                 280                 285             


Arg Cys Gln Gln Cys Pro Pro Gly Trp Val Leu Ser Glu Glu His Cys 
    290                 295                 300                 


Tyr Tyr Phe Ser Ala Glu Ala Gln Ala Trp Glu Ala Ser Gln Ala Phe 
305                 310                 315                 320 


Cys Ser Ala Tyr His Ala Thr Leu Pro Leu Leu Ser His Thr Gln Asp 
                325                 330                 335     


Phe Leu Gly Arg Tyr Pro Val Ser Arg His Ser Trp Val Gly Ala Trp 
            340                 345                 350         


Arg Gly Pro Gln Gly Trp His Trp Ile Asp Glu Ala Pro Leu Pro Pro 
        355                 360                 365             


Gln Leu Leu Pro Glu Asp Gly Glu Asp Asn Leu Asp Ile Asn Cys Gly 
    370                 375                 380                 


Ala Leu Glu Glu Gly Thr Leu Val Ala Ala Asn Cys Ser Thr Pro Arg 
385                 390                 395                 400 


Pro Trp Val Cys Ala Lys Gly Thr Gln 
                405                 


<210>  26
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Trp Gly Ser Glu Ser Ala Ala Val Arg Arg His Arg Val Gly 
1               5                   10                  15      


Val Glu Arg Arg Glu Gly Ala Ala Ala Ala Pro Pro Pro Glu Arg Glu 
            20                  25                  30          


Ala Arg Ala Gln Glu Pro Leu Val Asp Gly Cys Ser Gly Gly Gly Arg 
        35                  40                  45              


Thr Arg Lys Arg Ser Pro Gly Gly Ser Gly Gly Ala Ser Arg Gly Ala 
    50                  55                  60                  


Gly Thr Gly Leu Ser Glu Val Arg Ala Ala Leu Gly Leu Ala Leu Tyr 
65                  70                  75                  80  


Leu Ile Ala Leu Arg Thr Leu Val Gln Leu Ser Leu Gln Gln Leu Val 
                85                  90                  95      


Leu Arg Gly Ala Ala Gly His Arg Gly Glu Phe Asp Ala Leu Gln Ala 
            100                 105                 110         


Arg Asp Tyr Leu Glu His Ile Thr Ser Ile Gly Pro Arg Thr Thr Gly 
        115                 120                 125             


Ser Pro Glu Asn Glu Ile Leu Thr Val His Tyr Leu Leu Glu Gln Ile 
    130                 135                 140                 


Lys Leu Ile Glu Val Gln Ser Asn Ser Leu His Lys Ile Ser Val Asp 
145                 150                 155                 160 


Val Gln Arg Pro Thr Gly Ser Phe Ser Ile Asp Phe Leu Gly Gly Phe 
                165                 170                 175     


Thr Ser Tyr Tyr Asp Asn Ile Thr Asn Val Val Val Lys Leu Glu Pro 
            180                 185                 190         


Arg Asp Gly Ala Gln His Ala Val Leu Ala Asn Cys His Phe Asp Ser 
        195                 200                 205             


Val Ala Asn Ser Pro Gly Ala Ser Asp Asp Ala Val Ser Cys Ser Val 
    210                 215                 220                 


Met Leu Glu Val Leu Arg Val Leu Ser Thr Ser Ser Glu Ala Leu His 
225                 230                 235                 240 


His Ala Val Ile Phe Leu Phe Asn Gly Ala Glu Glu Asn Val Leu Gln 
                245                 250                 255     


Ala Ser His Gly Phe Ile Thr Gln His Pro Trp Ala Ser Leu Ile Arg 
            260                 265                 270         


Ala Phe Ile Asn Leu Glu Ala Ala Gly Val Gly Gly Lys Glu Leu Val 
        275                 280                 285             


Phe Gln Thr Gly Pro Glu Asn Pro Trp Leu Val Gln Ala Tyr Val Ser 
    290                 295                 300                 


Ala Ala Lys His Pro Phe Ala Ser Val Val Ala Gln Glu Val Phe Gln 
305                 310                 315                 320 


Ser Gly Ile Ile Pro Ser Asp Thr Asp Phe Arg Ile Tyr Arg Asp Phe 
                325                 330                 335     


Gly Asn Ile Pro Gly Ile Asp Leu Ala Phe Ile Glu Asn Gly Tyr Ile 
            340                 345                 350         


Tyr His Thr Lys Tyr Asp Thr Ala Asp Arg Ile Leu Thr Asp Ser Ile 
        355                 360                 365             


Gln Arg Ala Gly Asp Asn Ile Leu Ala Val Leu Lys His Leu Ala Thr 
    370                 375                 380                 


Ser Asp Met Leu Ala Ala Ala Ser Lys Tyr Arg His Gly Asn Met Val 
385                 390                 395                 400 


Phe Phe Asp Val Leu Gly Leu Phe Val Ile Ala Tyr Pro Ser Arg Ile 
                405                 410                 415     


Gly Ser Ile Ile Asn Tyr Met Val Val Met Gly Val Val Leu Tyr Leu 
            420                 425                 430         


Gly Lys Lys Phe Leu Gln Pro Lys His Lys Thr Gly Asn Tyr Lys Lys 
        435                 440                 445             


Asp Phe Leu Cys Gly Leu Gly Ile Thr Leu Ile Ser Trp Phe Thr Ser 
    450                 455                 460                 


Leu Val Thr Val Leu Ile Ile Ala Val Phe Ile Ser Leu Ile Gly Gln 
465                 470                 475                 480 


Ser Leu Ser Trp Tyr Asn His Phe Tyr Val Ser Val Cys Leu Tyr Gly 
                485                 490                 495     


Thr Ala Thr Val Ala Lys Ile Ile Leu Ile His Thr Leu Ala Lys Arg 
            500                 505                 510         


Phe Tyr Tyr Met Asn Ala Ser Ala Gln Tyr Leu Gly Glu Val Phe Phe 
        515                 520                 525             


Asp Ile Ser Leu Phe Val His Cys Cys Phe Leu Val Thr Leu Thr Tyr 
    530                 535                 540                 


Gln Gly Leu Cys Ser Ala Phe Ile Ser Ala Val Trp Val Ala Phe Pro 
545                 550                 555                 560 


Leu Leu Thr Lys Leu Cys Val His Lys Asp Phe Lys Gln His Gly Ala 
                565                 570                 575     


Gln Gly Lys Phe Ile Ala Phe Tyr Leu Leu Gly Met Phe Ile Pro Tyr 
            580                 585                 590         


Leu Tyr Ala Leu Tyr Leu Ile Trp Ala Val Phe Glu Met Phe Thr Pro 
        595                 600                 605             


Ile Leu Gly Arg Ser Gly Ser Glu Ile Pro Pro Asp Val Val Leu Ala 
    610                 615                 620                 


Ser Ile Leu Ala Gly Cys Thr Met Ile Leu Ser Ser Tyr Phe Ile Asn 
625                 630                 635                 640 


Phe Ile Tyr Leu Ala Lys Ser Thr Lys Lys Thr Met Leu Thr Leu Thr 
                645                 650                 655     


Leu Val Cys Ala Ile Thr Phe Leu Leu Val Cys Ser Gly Thr Phe Phe 
            660                 665                 670         


Pro Tyr Ser Ser Asn Pro Ala Asn Pro Lys Pro Lys Arg Val Phe Leu 
        675                 680                 685             


Gln His Met Thr Arg Thr Phe His Asp Leu Glu Gly Asn Ala Val Lys 
    690                 695                 700                 


Arg Asp Ser Gly Ile Trp Ile Asn Gly Phe Asp Tyr Thr Gly Ile Ser 
705                 710                 715                 720 


His Ile Thr Pro His Ile Pro Glu Ile Asn Asp Ser Ile Arg Ala His 
                725                 730                 735     


Cys Glu Glu Asn Ala Pro Leu Cys Gly Phe Pro Trp Tyr Leu Pro Val 
            740                 745                 750         


His Phe Leu Ile Arg Lys Asn Trp Tyr Leu Pro Ala Pro Glu Val Ser 
        755                 760                 765             


Pro Arg Asn Pro Pro His Phe Arg Leu Ile Ser Lys Glu Gln Thr Pro 
    770                 775                 780                 


Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Ser His Met 
785                 790                 795                 800 


Ser Phe Tyr Val Arg Ala His Lys Gly Ser Thr Leu Ser Gln Trp Ser 
                805                 810                 815     


Leu Gly Asn Gly Thr Pro Val Thr Ser Lys Gly Gly Asp Tyr Phe Val 
            820                 825                 830         


Phe Tyr Ser His Gly Leu Gln Ala Ser Ala Trp Gln Phe Trp Ile Glu 
        835                 840                 845             


Val Gln Val Ser Glu Glu His Pro Glu Gly Met Val Thr Val Ala Ile 
    850                 855                 860                 


Ala Ala His Tyr Leu Ser Gly Glu Asp Lys Arg Ser Pro Gln Leu Asp 
865                 870                 875                 880 


Ala Leu Lys Glu Lys Phe Pro Asp Trp Thr Phe Pro Ser Ala Trp Val 
                885                 890                 895     


Cys Thr Tyr Asp Leu Phe Val Phe 
            900                 


<210>  27
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Arg Gly Ala Gly Ala Lys Leu Leu Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Arg Ala Thr Gly Phe Thr Cys Ala Gln Thr Asp Gly Arg Asn Gly Tyr 
            20                  25                  30          


Thr Ala Val Ile Glu Val Thr Ser Gly Gly Pro Trp Gly Asp Trp Ala 
        35                  40                  45              


Trp Pro Glu Met Cys Pro Asp Gly Phe Phe Ala Ser Gly Phe Ser Leu 
    50                  55                  60                  


Lys Val Glu Pro Pro Gln Gly Ile Pro Gly Asp Asp Thr Ala Leu Asn 
65                  70                  75                  80  


Gly Ile Arg Leu His Cys Ala Arg Gly Asn Val Leu Gly Asn Thr His 
                85                  90                  95      


Val Val Glu Ser Gln Ser Gly Ser Trp Gly Glu Trp Ser Glu Pro Leu 
            100                 105                 110         


Trp Cys Arg Gly Gly Ala Tyr Leu Val Ala Phe Ser Leu Arg Val Glu 
        115                 120                 125             


Ala Pro Thr Thr Leu Gly Asp Asn Thr Ala Ala Asn Asn Val Arg Phe 
    130                 135                 140                 


Arg Cys Ser Asp Gly Glu Glu Leu Gln Gly Pro Gly Leu Ser Trp Gly 
145                 150                 155                 160 


Asp Phe Gly Asp Trp Ser Asp His Cys Pro Lys Gly Ala Cys Gly Leu 
                165                 170                 175     


Gln Thr Lys Ile Gln Gly Pro Arg Gly Leu Gly Asp Asp Thr Ala Leu 
            180                 185                 190         


Asn Asp Ala Arg Leu Phe Cys Cys Arg Ser 
        195                 200         


<210>  28
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Ser Met Lys Asn Gln 
1               5                   10                  15      


Lys Glu Phe Met Leu Met Asn Ala Arg Leu Gln Leu Glu Arg Gln Leu 
            20                  25                  30          


Ile Met Gln Ser Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala 
        35                  40                  45              


Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Leu Ala 
    50                  55                  60                  


Ala Ile Ser Leu Thr Ala Gly Ala Ile Lys Lys Lys Lys Pro Ala Phe 
65                  70                  75                  80  


Leu Val Pro Ile Val Pro Leu Ser Phe Ile Leu Thr Tyr Gln Tyr Asp 
                85                  90                  95      


Leu Gly Tyr Gly Thr Leu Leu Glu Arg Met Lys Gly Glu Ala Glu Asp 
            100                 105                 110         


Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu Pro Arg Gly Met Ile 
        115                 120                 125             


Thr Phe Glu Ser Ile Glu Lys Ala Arg Lys Glu Gln Ser Arg Phe Phe 
    130                 135                 140                 


Ile Asp Lys 
145         


<210>  29
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Lys Gln Gly Val Ser Ser Lys Arg Leu Gln Ser Ser Gly Arg 
1               5                   10                  15      


Ser Gln Ser Lys Gly Arg Arg Gly Ala Ser Leu Ala Arg Glu Pro Glu 
            20                  25                  30          


Val Glu Glu Glu Met Glu Lys Ser Ala Leu Gly Gly Gly Lys Leu Pro 
        35                  40                  45              


Arg Gly Ser Trp Arg Ser Ser Pro Gly Arg Ile Gln Ser Leu Lys Glu 
    50                  55                  60                  


Arg Lys Gly Leu Glu Leu Glu Val Val Ala Lys Thr Phe Leu Leu Gly 
65                  70                  75                  80  


Pro Phe Gln Phe Val Arg Asn Ser Leu Ala Gln Leu Arg Glu Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Ala Arg Arg Phe Ser Ser Arg Thr Thr Leu Gly Ile 
            100                 105                 110         


Ala Val Phe Val Ala Ile Leu His Trp Leu His Leu Val Thr Leu Phe 
        115                 120                 125             


Glu Asn Asp Arg His Phe Ser His Leu Ser Ser Leu Glu Arg Glu Met 
    130                 135                 140                 


Thr Phe Arg Thr Glu Met Gly Leu Tyr Tyr Ser Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Ile Glu Ala Pro Ser Phe Leu Glu Gly Leu Trp Met Ile Met Asn Asp 
                165                 170                 175     


Arg Leu Thr Glu Tyr Pro Leu Ile Ile Asn Ala Ile Lys Arg Phe His 
            180                 185                 190         


Leu Tyr Pro Glu Val Ile Ile Ala Ser Trp Tyr Cys Thr Phe Met Gly 
        195                 200                 205             


Ile Met Asn Leu Phe Gly Leu Glu Thr Lys Thr Cys Trp Asn Val Thr 
    210                 215                 220                 


Arg Ile Glu Pro Leu Asn Glu Val Gln Ser Cys Glu Gly Leu Gly Asp 
225                 230                 235                 240 


Pro Ala Cys Phe Tyr Val Gly Val Ile Phe Ile Leu Asn Gly Leu Met 
                245                 250                 255     


Met Gly Leu Phe Phe Met Tyr Gly Ala Tyr Leu Ser Gly Thr Gln Leu 
            260                 265                 270         


Gly Gly Leu Ile Thr Val Leu Cys Phe Phe Phe Asn His Gly Glu Ala 
        275                 280                 285             


Thr Arg Val Met Trp Thr Pro Pro Leu Arg Glu Ser Phe Ser Tyr Pro 
    290                 295                 300                 


Phe Leu Val Leu Gln Met Cys Ile Leu Thr Leu Ile Leu Arg Thr Ser 
305                 310                 315                 320 


Ser Asn Asp Arg Arg Pro Phe Ile Ala Leu Cys Leu Ser Asn Val Ala 
                325                 330                 335     


Phe Met Leu Pro Trp Gln Phe Ala Gln Phe Ile Leu Phe Thr Gln Ile 
            340                 345                 350         


Ala Ser Leu Phe Pro Met Tyr Val Val Gly Tyr Ile Glu Pro Ser Lys 
        355                 360                 365             


Phe Gln Lys Ile Ile Tyr Met Asn Met Ile Ser Val Thr Leu Ser Phe 
    370                 375                 380                 


Ile Leu Met Phe Gly Asn Ser Met Tyr Leu Ser Ser Tyr Tyr Ser Ser 
385                 390                 395                 400 


Ser Leu Leu Met Thr Trp Ala Ile Ile Leu Lys Arg Asn Glu Ile Gln 
                405                 410                 415     


Lys Leu Gly Val Ser Lys Leu Asn Phe Trp Leu Ile Gln Gly Ser Ala 
            420                 425                 430         


Trp Trp Cys Gly Thr Ile Ile Leu Lys Phe Leu Thr Ser Lys Ile Leu 
        435                 440                 445             


Gly Val Ser Asp His Ile Arg Leu Ser Asp Leu Ile Ala Ala Arg Ile 
    450                 455                 460                 


Leu Arg Tyr Thr Asp Phe Asp Thr Leu Ile Tyr Thr Cys Ala Pro Glu 
465                 470                 475                 480 


Phe Asp Phe Met Glu Lys Ala Thr Pro Leu Arg Tyr Thr Lys Thr Leu 
                485                 490                 495     


Leu Leu Pro Val Val Met Val Ile Thr Cys Phe Ile Phe Lys Lys Thr 
            500                 505                 510         


Val Arg Asp Ile Ser Tyr Val Leu Ala Thr Asn Ile Tyr Leu Arg Lys 
        515                 520                 525             


Gln Leu Leu Glu His Ser Glu Leu Ala Phe His Thr Leu Gln Leu Leu 
    530                 535                 540                 


Val Phe Thr Ala Leu Ala Ile Leu Ile Met Arg Leu Lys Met Phe Leu 
545                 550                 555                 560 


Thr Pro His Met Cys Val Met Ala Ser Leu Ile Cys Ser Arg Gln Leu 
                565                 570                 575     


Phe Gly Trp Leu Phe Arg Arg Val Arg Phe Glu Lys Val Ile Phe Gly 
            580                 585                 590         


Ile Leu Thr Val Met Ser Ile Gln Gly Tyr Ala Asn Leu Arg Asn Gln 
        595                 600                 605             


Trp Ser Ile Ile Gly Glu Phe Asn Asn Leu Pro Gln Glu Glu Leu Leu 
    610                 615                 620                 


Gln Trp Ile Lys Tyr Ser Thr Thr Ser Asp Ala Val Phe Ala Gly Ala 
625                 630                 635                 640 


Met Pro Thr Met Ala Ser Ile Lys Leu Ser Thr Leu His Pro Ile Val 
                645                 650                 655     


Asn His Pro His Tyr Glu Asp Ala Asp Leu Arg Ala Arg Thr Lys Ile 
            660                 665                 670         


Val Tyr Ser Thr Tyr Ser Arg Lys Ser Ala Lys Glu Val Arg Asp Lys 
        675                 680                 685             


Leu Leu Glu Leu His Val Asn Tyr Tyr Val Leu Glu Glu Ala Trp Cys 
    690                 695                 700                 


Val Val Arg Thr Lys Pro Gly Cys Ser Met Leu Glu Ile Trp Asp Val 
705                 710                 715                 720 


Glu Asp Pro Ser Asn Ala Ala Asn Pro Pro Leu Cys Ser Val Leu Leu 
                725                 730                 735     


Glu Asp Ala Arg Pro Tyr Phe Thr Thr Val Phe Gln Asn Ser Val Tyr 
            740                 745                 750         


Arg Val Leu Lys Val Asn 
        755             


<210>  30
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ser Ala Asp Glu Leu Thr Phe His Glu Phe Glu Glu Ala Thr 
1               5                   10                  15      


Asn Leu Leu Ala Asp Thr Pro Asp Ala Ala Thr Thr Ser Arg Ser Asp 
            20                  25                  30          


Gln Leu Thr Pro Gln Gly His Val Ala Val Ala Val Gly Ser Gly Gly 
        35                  40                  45              


Ser Tyr Gly Ala Glu Asp Glu Val Glu Glu Glu Ser Asp Lys Ala Ala 
    50                  55                  60                  


Leu Leu Gln Glu Gln Gln Gln Gln Gln Gln Pro Gly Phe Trp Thr Phe 
65                  70                  75                  80  


Ser Tyr Tyr Gln Ser Phe Phe Asp Val Asp Thr Ser Gln Val Leu Asp 
                85                  90                  95      


Arg Ile Lys Gly Ser Leu Leu Pro Arg Pro Gly His Asn Phe Val Arg 
            100                 105                 110         


His His Leu Arg Asn Arg Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys 
        115                 120                 125             


Ala Thr Leu Ala Phe Val Leu Ala Val Thr Gly Asn Leu Thr Leu Val 
    130                 135                 140                 


Leu Ala Gln Arg Arg Asp Pro Ser Ile His Tyr Ser Pro Gln Phe His 
145                 150                 155                 160 


Lys Val Thr Val Ala Gly Ile Ser Ile Tyr Cys Tyr Ala Trp Leu Val 
                165                 170                 175     


Pro Leu Ala Leu Trp Gly Phe Leu Arg Trp Arg Lys Gly Val Gln Glu 
            180                 185                 190         


Arg Met Gly Pro Tyr Thr Phe Leu Glu Thr Val Cys Ile Tyr Gly Tyr 
        195                 200                 205             


Ser Leu Phe Val Phe Ile Pro Met Val Val Leu Trp Leu Ile Pro Val 
    210                 215                 220                 


Pro Trp Leu Gln Trp Leu Phe Gly Ala Leu Ala Leu Gly Leu Ser Ala 
225                 230                 235                 240 


Ala Gly Leu Val Phe Thr Leu Trp Pro Val Val Arg Glu Asp Thr Arg 
                245                 250                 255     


Leu Val Ala Thr Val Leu Leu Ser Val Val Val Leu Leu His Ala Leu 
            260                 265                 270         


Leu Ala Met Gly Cys Lys Leu Tyr Phe Phe Gln Ser Leu Pro Pro Glu 
        275                 280                 285             


Asn Val Ala Pro Pro Pro Gln Ile Thr Ser Leu Pro Ser Asn Ile Ala 
    290                 295                 300                 


Leu Ser Pro Thr Leu Pro Gln Ser Leu Ala Pro Ser 
305                 310                 315     


<210>  31
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Phe Ile Leu Leu Trp Ala Leu Leu Asn Leu Thr Val Ala Leu 
1               5                   10                  15      


Ala Phe Asn Pro Asp Tyr Thr Val Ser Ser Thr Pro Pro Tyr Leu Val 
            20                  25                  30          


Tyr Leu Lys Ser Asp Tyr Leu Pro Cys Ala Gly Val Leu Ile His Pro 
        35                  40                  45              


Leu Trp Val Ile Thr Ala Ala His Cys Asn Leu Pro Lys Leu Arg Val 
    50                  55                  60                  


Ile Leu Gly Val Thr Ile Pro Ala Asp Ser Asn Glu Lys His Leu Gln 
65                  70                  75                  80  


Val Ile Gly Tyr Glu Lys Met Ile His His Pro His Phe Ser Val Thr 
                85                  90                  95      


Ser Ile Asp His Asp Ile Met Leu Ile Lys Leu Lys Thr Glu Ala Glu 
            100                 105                 110         


Leu Asn Asp Tyr Val Lys Leu Ala Asn Leu Pro Tyr Gln Thr Ile Ser 
        115                 120                 125             


Glu Asn Thr Met Cys Ser Val Ser Thr Trp Ser Tyr Asn Val Cys Asp 
    130                 135                 140                 


Ile Tyr Lys Glu Pro Asp Ser Leu Gln Thr Val Asn Ile Ser Val Ile 
145                 150                 155                 160 


Ser Lys Pro Gln Cys Arg Asp Ala Tyr Lys Thr Tyr Asn Ile Thr Glu 
                165                 170                 175     


Asn Met Leu Cys Val Gly Ile Val Pro Gly Arg Arg Gln Pro Cys Lys 
            180                 185                 190         


Glu Val Ser Ala Ala Pro Ala Ile Cys Asn Gly Met Leu Gln Gly Ile 
        195                 200                 205             


Leu Ser Phe Ala Asp Gly Cys Val Leu Arg Ala Asp Val Gly Ile Tyr 
    210                 215                 220                 


Ala Lys Ile Phe Tyr Tyr Ile Pro Trp Ile Glu Asn Val Ile Gln Asn 
225                 230                 235                 240 


Asn 
    


<210>  32
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Pro Asp Val Pro Leu Leu Asn Asp Tyr Lys Gln Asp Phe Phe 
1               5                   10                  15      


Leu Lys Arg Phe Pro Gln Thr Val Leu Gly Gly Pro Arg Phe Lys Leu 
            20                  25                  30          


Gly Tyr Cys Ala Pro Pro Tyr Ile Tyr Val Asn Gln Ile Ile Leu Phe 
        35                  40                  45              


Leu Met Pro Trp Val Trp Gly Gly Val Gly Thr Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Gly Ile Leu Lys Asp Tyr Tyr Thr Ala Ala Leu Ser Gly Gly Leu Met 
65                  70                  75                  80  


Leu Phe Thr Ala Phe Val Ile Gln Phe Thr Ser Leu Tyr Ala Lys Asn 
                85                  90                  95      


Lys Ser Thr Thr Val Glu Arg Ile Leu Thr Thr Asp Ile Leu Ala Glu 
            100                 105                 110         


Glu Asp Glu His Glu Phe Thr Ser Cys Thr Gly Ala Glu Thr Val Lys 
        115                 120                 125             


Phe Leu Ile Pro Gly Lys Lys Tyr Val Ala Asn Thr Val Phe His Ser 
    130                 135                 140                 


Ile Leu Ala Gly Leu Ala Cys Gly Leu Gly Thr Trp Tyr Leu Leu Pro 
145                 150                 155                 160 


Asn Arg Ile Thr Leu Leu Tyr Gly Ser Thr Gly Gly Thr Ala Leu Leu 
                165                 170                 175     


Phe Phe Phe Gly Trp Met Thr Leu Cys Ile Ala Glu Tyr Ser Leu Ile 
            180                 185                 190         


Val Asn Thr Ala Thr Glu Thr Ala Thr Phe Gln Thr Gln Asp Thr Tyr 
        195                 200                 205             


Glu Ile Ile Pro Leu Met Arg Pro Leu Tyr Ile Phe Phe Phe Val Ser 
    210                 215                 220                 


Val Asp Leu Ala His Arg Phe Val Val Asn Met Pro Ala Leu Glu His 
225                 230                 235                 240 


Met Asn Gln Ile Leu His Ile Leu Phe Val Phe Leu Pro Phe Leu Trp 
                245                 250                 255     


Ala Leu Gly Thr Leu Pro Pro Pro Asp Ala Leu Leu Leu Trp Ala Met 
            260                 265                 270         


Glu Gln Val Leu Glu Phe Gly Leu Gly Gly Ser Ser Met Ser Thr His 
        275                 280                 285             


Leu Arg Leu Leu Val Met Phe Ile Met Ser Ala Gly Thr Ala Ile Ala 
    290                 295                 300                 


Ser Tyr Phe Ile Pro Ser Thr Val Gly Val Val Leu Phe Met Thr Gly 
305                 310                 315                 320 


Phe Gly Phe Leu Leu Ser Leu Asn Leu Ser Asp Met Gly His Lys Ile 
                325                 330                 335     


Gly Thr Lys Ser Lys Asp Leu Pro Ser Gly Pro Glu Lys His Phe Ser 
            340                 345                 350         


Trp Lys Glu Cys Leu Phe Tyr Ile Ile Ile Leu Val Leu Ala Leu Leu 
        355                 360                 365             


Glu Thr Ser Leu Leu His His Phe Ala Gly Phe Ser Gln Ile Ser Lys 
    370                 375                 380                 


Ser Asn Ser Gln Ala Ile Val Gly Tyr Gly Leu Met Ile Leu Leu Ile 
385                 390                 395                 400 


Ile Leu Trp Ile Leu Arg Glu Ile Gln Ser Val Tyr Ile Ile Gly Ile 
                405                 410                 415     


Phe Arg Asn Pro Phe Tyr Pro Lys Asp Val Gln Thr Val Thr Val Phe 
            420                 425                 430         


Phe Glu Lys Gln Thr Arg Leu Met Lys Ile Gly Ile Val Arg Arg Ile 
        435                 440                 445             


Leu Leu Thr Leu Val Ser Pro Phe Ala Met Ile Ala Phe Leu Ser Leu 
    450                 455                 460                 


Asp Ser Ser Leu Gln Gly Leu His Ser Val Ser Val Cys Ile Gly Phe 
465                 470                 475                 480 


Thr Arg Ala Phe Arg Met Val Trp Gln Asn Thr Glu Asn Ala Leu Leu 
                485                 490                 495     


Glu Thr Val Ile Val Ser Thr Val His Leu Ile Ser Ser Thr Asp Ile 
            500                 505                 510         


Trp Trp Asn Arg Ser Leu Asp Thr Gly Leu Arg Leu Leu Leu Val Gly 
        515                 520                 525             


Ile Ile Arg Asp Arg Leu Ile Gln Phe Ile Ser Lys Leu Gln Phe Ala 
    530                 535                 540                 


Val Thr Val Leu Leu Thr Ser Trp Thr Glu Lys Lys Gln Arg Arg Lys 
545                 550                 555                 560 


Thr Thr Ala Thr Leu Cys Ile Leu Asn Ile Val Phe Ser Pro Phe Val 
                565                 570                 575     


Leu Val Ile Ile Val Phe Ser Thr Leu Leu Ser Ser Pro Leu Leu Pro 
            580                 585                 590         


Leu Phe Thr Leu Pro Val Phe Leu Val Gly Phe Pro Arg Pro Ile Gln 
        595                 600                 605             


Ser Trp Pro Gly Ala Ala Gly Thr Thr Ala Cys Val Cys Ala Asp Thr 
    610                 615                 620                 


Val Tyr Tyr Tyr Gln Met Val Pro Arg Leu Thr Ala Val Leu Gln Thr 
625                 630                 635                 640 


Ala Met Ala Ala Gly Ser Leu Gly Leu Leu Leu Pro Gly Ser His Tyr 
                645                 650                 655     


Leu Gly Arg Phe Gln Asp Arg Leu Met Trp Ile Met Ile Leu Glu Cys 
            660                 665                 670         


Gly Tyr Thr Tyr Cys Ser Ile Asn Ile Lys Gly Leu Glu Leu Gln Glu 
        675                 680                 685             


Thr Ser Cys His Thr Ala Glu Ala Arg Arg Val Asp Glu Val Phe Glu 
    690                 695                 700                 


Asp Ala Phe Glu Gln Glu Tyr Thr Arg Val Cys Ser Leu Asn Glu His 
705                 710                 715                 720 


Phe Gly Asn Val Leu Thr Pro Cys Thr Val Leu Pro Val Lys Leu Tyr 
                725                 730                 735     


Ser Asp Ala Arg Asn Val Leu Ser Gly Ile Ile Asp Ser His Glu Asn 
            740                 745                 750         


Leu Lys Glu Phe Lys Gly Asp Leu Ile Lys Val Leu Val Trp Ile Leu 
        755                 760                 765             


Val Gln Tyr Cys Ser Lys Arg Pro Gly Met Lys Glu Asn Val His Asn 
    770                 775                 780                 


Thr Glu Asn Lys Gly Lys Ala Pro Leu Met Leu Pro Ala Leu Asn Thr 
785                 790                 795                 800 


Leu Pro Pro Pro Lys Ser Pro Glu Asp Ile Asp Ser Leu Asn Ser Glu 
                805                 810                 815     


Thr Phe Asn Asp Trp Ser Asp Asp Asn Ile Phe Asp Asp Glu Pro Thr 
            820                 825                 830         


Ile Lys Lys Val Ile Glu Glu Lys His Gln Leu Lys Asp Leu Pro Gly 
        835                 840                 845             


Thr Asn Leu Phe Ile Pro Gly Ser Val Glu Ser Gln Arg Val Gly Asp 
    850                 855                 860                 


His Ser Thr Gly Thr Val Pro Glu Asn Asp Leu Tyr Lys Ala Val Leu 
865                 870                 875                 880 


Leu Gly Tyr Pro Ala Val Asp Lys Gly Lys Gln Glu Asp Met Pro Tyr 
                885                 890                 895     


Ile Pro Leu Met Glu Phe Ser Cys Ser His Ser His Leu Val Cys Leu 
            900                 905                 910         


Pro Ala Glu Trp Arg Thr Ser Cys Met Pro Ser Ser Lys Met Lys Glu 
        915                 920                 925             


Met Ser Ser Leu Phe Pro Glu Asp Trp Tyr Gln Phe Val Leu Arg Gln 
    930                 935                 940                 


Leu Glu Cys Tyr His Ser Glu Glu Lys Ala Ser Asn Val Leu Glu Glu 
945                 950                 955                 960 


Ile Ala Lys Asp Lys Val Leu Lys Asp Phe Tyr Val His Thr Val Met 
                965                 970                 975     


Thr Cys Tyr Phe Ser Leu Phe Gly Ile Asp Asn Met Ala Pro Ser Pro 
            980                 985                 990         


Gly His Ile Leu Arg Val Tyr Gly  Gly Val Leu Pro Trp  Ser Val Ala 
        995                 1000                 1005             


Leu Asp  Trp Leu Thr Glu Lys  Pro Glu Leu Phe Gln  Leu Ala Leu 
    1010                 1015                 1020             


Lys Ala  Phe Arg Tyr Thr Leu  Lys Leu Met Ile Asp  Lys Ala Ser 
    1025                 1030                 1035             


Leu Gly  Pro Ile Glu Asp Phe  Arg Glu Leu Ile Lys  Tyr Leu Glu 
    1040                 1045                 1050             


Glu Tyr  Glu Arg Asp Trp Tyr  Ile Gly Leu Val Ser  Asp Glu Lys 
    1055                 1060                 1065             


Trp Lys  Glu Ala Ile Leu Gln  Glu Lys Pro Tyr Leu  Phe Ser Leu 
    1070                 1075                 1080             


Gly Tyr  Asp Ser Asn Met Gly  Ile Tyr Thr Gly Arg  Val Leu Ser 
    1085                 1090                 1095             


Leu Gln  Glu Leu Leu Ile Gln  Val Gly Lys Leu Asn  Pro Glu Ala 
    1100                 1105                 1110             


Val Arg  Gly Gln Trp Ala Asn  Leu Ser Trp Glu Leu  Leu Tyr Ala 
    1115                 1120                 1125             


Thr Asn  Asp Asp Glu Glu Arg  Tyr Ser Ile Gln Ala  His Pro Leu 
    1130                 1135                 1140             


Leu Leu  Arg Asn Leu Thr Val  Gln Ala Ala Glu Pro  Pro Leu Gly 
    1145                 1150                 1155             


Tyr Pro  Ile Tyr Ser Ser Lys  Pro Leu His Ile His  Leu Tyr 
    1160                 1165                 1170         


<210>  33
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  34
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu Pro Gln Ala Glu Ser Glu Pro Leu Leu Gly Gly Ala Arg 
1               5                   10                  15      


Gly Gly Gly Gly Asp Trp Pro Ala Gly Leu Thr Thr Tyr Arg Ser Ile 
            20                  25                  30          


Gln Val Gly Pro Gly Ala Ala Ala Arg Trp Asp Leu Cys Ile Asp Gln 
        35                  40                  45              


Ala Val Val Phe Ile Glu Asp Ala Ile Gln Tyr Arg Ser Ile Asn His 
    50                  55                  60                  


Arg Val Asp Ala Ser Ser Met Trp Leu Tyr Arg Arg Tyr Tyr Ser Asn 
65                  70                  75                  80  


Val Cys Gln Arg Thr Leu Ser Phe Thr Ile Phe Leu Ile Leu Phe Leu 
                85                  90                  95      


Ala Phe Ile Glu Thr Pro Ser Ser Leu Thr Ser Thr Ala Asp Val Arg 
            100                 105                 110         


Tyr Arg Ala Ala Pro Trp Glu Pro Pro Cys Gly Leu Thr Glu Ser Val 
        115                 120                 125             


Glu Val Leu Cys Leu Leu Val Phe Ala Ala Asp Leu Ser Val Lys Gly 
    130                 135                 140                 


Tyr Leu Phe Gly Trp Ala His Phe Gln Lys Asn Leu Trp Leu Leu Gly 
145                 150                 155                 160 


Tyr Leu Val Val Leu Val Val Ser Leu Val Asp Trp Thr Val Ser Leu 
                165                 170                 175     


Ser Leu Val Cys His Glu Pro Leu Arg Ile Arg Arg Leu Leu Arg Pro 
            180                 185                 190         


Phe Phe Leu Leu Gln Asn Ser Ser Met Met Lys Lys Thr Leu Lys Cys 
        195                 200                 205             


Ile Arg Trp Ser Leu Pro Glu Met Ala Ser Val Gly Leu Leu Leu Ala 
    210                 215                 220                 


Ile His Leu Cys Leu Phe Thr Met Phe Gly Met Leu Leu Phe Ala Gly 
225                 230                 235                 240 


Gly Lys Gln Asp Asp Gly Gln Asp Arg Glu Arg Leu Thr Tyr Phe Gln 
                245                 250                 255     


Asn Leu Pro Glu Ser Leu Thr Ser Leu Leu Val Leu Leu Thr Thr Ala 
            260                 265                 270         


Asn Asn Pro Asp Val Met Ile Pro Ala Tyr Ser Lys Asn Arg Ala Tyr 
        275                 280                 285             


Ala Ile Phe Phe Ile Val Phe Thr Val Ile Gly Ser Leu Phe Leu Met 
    290                 295                 300                 


Asn Leu Leu Thr Ala Ile Ile Tyr Ser Gln Phe Arg Gly Tyr Leu Met 
305                 310                 315                 320 


Lys Ser Leu Gln Thr Ser Leu Phe Arg Arg Arg Leu Gly Thr Arg Ala 
                325                 330                 335     


Ala Phe Glu Val Leu Ser Ser Met Val Gly Glu Gly Gly Ala Phe Pro 
            340                 345                 350         


Gln Ala Val Gly Val Lys Pro Gln Asn Leu Leu Gln Val Leu Gln Lys 
        355                 360                 365             


Val Gln Leu Asp Ser Ser His Lys Gln Ala Met Met Glu Lys Val Arg 
    370                 375                 380                 


Ser Tyr Gly Ser Val Leu Leu Ser Ala Glu Glu Phe Gln Lys Leu Phe 
385                 390                 395                 400 


Asn Glu Leu Asp Arg Ser Val Val Lys Glu His Pro Pro Arg Pro Glu 
                405                 410                 415     


Tyr Gln Ser Pro Phe Leu Gln Ser Ala Gln Phe Leu Phe Gly His Tyr 
            420                 425                 430         


Tyr Phe Asp Tyr Leu Gly Asn Leu Ile Ala Leu Ala Asn Leu Val Ser 
        435                 440                 445             


Ile Cys Val Phe Leu Val Leu Asp Ala Asp Val Leu Pro Ala Glu Arg 
    450                 455                 460                 


Asp Asp Phe Ile Leu Gly Ile Leu Asn Cys Val Phe Ile Val Tyr Tyr 
465                 470                 475                 480 


Leu Leu Glu Met Leu Leu Lys Val Phe Ala Leu Gly Leu Arg Gly Tyr 
                485                 490                 495     


Leu Ser Tyr Pro Ser Asn Val Phe Asp Gly Leu Leu Thr Val Val Leu 
            500                 505                 510         


Leu Val Leu Glu Ile Ser Thr Leu Ala Val Tyr Arg Leu Pro His Pro 
        515                 520                 525             


Gly Trp Arg Pro Glu Met Val Gly Leu Leu Ser Leu Trp Asp Met Thr 
    530                 535                 540                 


Arg Met Leu Asn Met Leu Ile Val Phe Arg Phe Leu Arg Ile Ile Pro 
545                 550                 555                 560 


Ser Met Lys Leu Met Ala Val Val Ala Ser Thr Val Leu Gly Leu Val 
                565                 570                 575     


Gln Asn Met Arg Ala Phe Gly Gly Ile Leu Val Val Val Tyr Tyr Val 
            580                 585                 590         


Phe Ala Ile Ile Gly Ile Asn Leu Phe Arg Gly Val Ile Val Ala Leu 
        595                 600                 605             


Pro Gly Asn Ser Ser Leu Ala Pro Ala Asn Gly Ser Ala Pro Cys Gly 
    610                 615                 620                 


Ser Phe Glu Gln Leu Glu Tyr Trp Ala Asn Asn Phe Asp Asp Phe Ala 
625                 630                 635                 640 


Ala Ala Leu Val Thr Leu Trp Asn Leu Met Val Val Asn Asn Trp Gln 
                645                 650                 655     


Val Phe Leu Asp Ala Tyr Arg Arg Tyr Ser Gly Pro Trp Ser Lys Ile 
            660                 665                 670         


Tyr Phe Val Leu Trp Trp Leu Val Ser Ser Val Ile Trp Val Asn Leu 
        675                 680                 685             


Phe Leu Ala Leu Ile Leu Glu Asn Phe Leu His Lys Trp Asp Pro Arg 
    690                 695                 700                 


Ser His Leu Gln Pro Leu Ala Gly Thr Pro Glu Ala Thr Tyr Gln Met 
705                 710                 715                 720 


Thr Val Glu Leu Leu Phe Arg Asp Ile Leu Glu Glu Pro Gly Glu Asp 
                725                 730                 735     


Glu Leu Thr Glu Arg Leu Ser Gln His Pro His Leu Trp Leu Cys Arg 
            740                 745                 750         


<210>  35
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gln Trp Asn Val Pro Arg Thr Val Ser Arg Leu Ala Arg Arg Thr 
1               5                   10                  15      


Cys Leu Glu Pro His Asn Ala Gly Leu Phe Gly His Cys Gln Asn Val 
            20                  25                  30          


Lys Gly Pro Leu Leu Leu Tyr Asn Ala Glu Ser Lys Val Val Leu Val 
        35                  40                  45              


Gln Gly Pro Gln Lys Gln Trp Leu His Leu Ser Ala Ala Gln Cys Val 
    50                  55                  60                  


Ala Lys Glu Arg Arg Pro Leu Asp Ala His Pro Pro Gln Pro Gly Val 
65                  70                  75                  80  


Leu Arg His Lys Gln Gly Lys Gln His Val Ser Phe Arg Arg Val Phe 
                85                  90                  95      


Ser Ser Ser Ala Thr Ala Gln Gly Thr Pro Glu Lys Lys Glu Glu Pro 
            100                 105                 110         


Asp Pro Leu Gln Asp Lys Ser Ile Ser Leu Tyr Gln Arg Phe Lys Lys 
        115                 120                 125             


Thr Phe Arg Gln Tyr Gly Lys Val Leu Ile Pro Val His Leu Ile Thr 
    130                 135                 140                 


Ser Gly Val Trp Phe Gly Thr Phe Tyr Tyr Ala Ala Leu Lys Gly Val 
145                 150                 155                 160 


Asn Val Val Pro Phe Leu Glu Leu Ile Gly Leu Pro Asp Ser Val Val 
                165                 170                 175     


Ser Ile Leu Lys Asn Ser Gln Ser Gly Asn Ala Leu Thr Ala Tyr Ala 
            180                 185                 190         


Leu Phe Lys Ile Ala Thr Pro Ala Arg Tyr Thr Val Thr Leu Gly Gly 
        195                 200                 205             


Thr Ser Val Thr Val Lys Tyr Leu Arg Ser His Gly Tyr Met Ser Thr 
    210                 215                 220                 


Pro Pro Pro Val Lys Glu Tyr Leu Gln Asp Arg Met Glu Glu Thr Lys 
225                 230                 235                 240 


Glu Leu Ile Thr Glu Lys Met Glu Glu Thr Lys Asp Arg Leu Thr Glu 
                245                 250                 255     


Lys Leu Gln Glu Thr Lys Glu Lys Val Ser Phe Lys Lys Lys Val Glu 
            260                 265                 270         


<210>  36
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Met Val Ala Leu Arg Gly Ala Ser Ala Leu Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Ala Phe Leu Pro Pro Pro Gln Cys Thr Gln Asp Pro Ala Met Val 
            20                  25                  30          


His Tyr Ile Tyr Gln Arg Phe Arg Val Leu Glu Gln Gly Leu Glu Lys 
        35                  40                  45              


Cys Thr Gln Ala Thr Arg Ala Tyr Ile Gln Glu Phe Gln Glu Phe Ser 
    50                  55                  60                  


Lys Asn Ile Ser Val Met Leu Gly Arg Cys Gln Thr Tyr Thr Ser Glu 
65                  70                  75                  80  


Tyr Lys Ser Ala Val Gly Asn Leu Ala Leu Arg Val Glu Arg Ala Gln 
                85                  90                  95      


Arg Glu Ile Asp Tyr Ile Gln Tyr Leu Arg Glu Ala Asp Glu Cys Ile 
            100                 105                 110         


Glu Ser Glu Asp Lys Thr Leu Ala Glu Met Leu Leu Gln Glu Ala Glu 
        115                 120                 125             


Glu Glu Lys Lys Ile Arg Thr Leu Leu Asn Ala Ser Cys Asp Asn Met 
    130                 135                 140                 


Leu Met Gly Ile Lys Ser Leu Lys Ile Val Lys Lys Met Met Asp Thr 
145                 150                 155                 160 


His Gly Ser Trp Met Lys Asp Ala Val Tyr Asn Ser Pro Lys Val Tyr 
                165                 170                 175     


Leu Leu Ile Gly Ser Arg Asn Asn Thr Val Trp Glu Phe Ala Asn Ile 
            180                 185                 190         


Arg Ala Phe Met Glu Asp Asn Thr Lys Pro Ala Pro Arg Lys Gln Ile 
        195                 200                 205             


Leu Thr Leu Ser Trp Gln Gly Thr Gly Gln Val Ile Tyr Lys Gly Phe 
    210                 215                 220                 


Leu Phe Phe His Asn Gln Ala Thr Ser Asn Glu Ile Ile Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Lys Arg Thr Val Glu Asp Arg Met Leu Leu Pro Gly Gly Val 
                245                 250                 255     


Gly Arg Ala Leu Val Tyr Gln His Ser Pro Ser Thr Tyr Ile Asp Leu 
            260                 265                 270         


Ala Val Asp Glu His Gly Leu Trp Ala Ile His Ser Gly Pro Gly Thr 
        275                 280                 285             


His Ser His Leu Val Leu Thr Lys Ile Glu Pro Gly Thr Leu Gly Val 
    290                 295                 300                 


Glu His Ser Trp Asp Thr Pro Cys Arg Ser Gln Asp Ala Glu Ala Ser 
305                 310                 315                 320 


Phe Leu Leu Cys Gly Val Leu Tyr Val Val Tyr Ser Thr Gly Gly Gln 
                325                 330                 335     


Gly Pro His Arg Ile Thr Cys Ile Tyr Asp Pro Leu Gly Thr Ile Ser 
            340                 345                 350         


Glu Glu Asp Leu Pro Asn Leu Phe Phe Pro Lys Arg Pro Arg Ser His 
        355                 360                 365             


Ser Met Ile His Tyr Asn Pro Arg Asp Lys Gln Leu Tyr Ala Trp Asn 
    370                 375                 380                 


Glu Gly Asn Gln Ile Ile Tyr Lys Leu Gln Thr Lys Arg Lys Leu Pro 
385                 390                 395                 400 


Leu Lys 
        


<210>  37
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Pro Gln His Leu Arg Leu Val Gln Leu Phe Cys Leu Leu Gly 
1               5                   10                  15      


Ala Ile Ser Thr Leu Pro Arg Ala Gly Ala Leu Leu Cys Tyr Glu Ala 
            20                  25                  30          


Thr Ala Ser Arg Phe Arg Ala Val Ala Phe His Asn Trp Lys Trp Leu 
        35                  40                  45              


Leu Met Arg Asn Met Val Cys Lys Leu Gln Glu Gly Cys Glu Glu Thr 
    50                  55                  60                  


Leu Val Phe Ile Glu Thr Gly Thr Ala Arg Gly Val Val Gly Phe Lys 
65                  70                  75                  80  


Gly Cys Ser Ser Ser Ser Ser Tyr Pro Ala Gln Ile Ser Tyr Leu Val 
                85                  90                  95      


Ser Pro Pro Gly Val Ser Ile Ala Ser Tyr Ser Arg Val Cys Arg Ser 
            100                 105                 110         


Tyr Leu Cys Asn Asn Leu Thr Asn Leu Glu Pro Phe Val Lys Leu Lys 
        115                 120                 125             


Ala Ser Thr Pro Lys Ser Ile Thr Ser Ala Ser Cys Ser Cys Pro Thr 
    130                 135                 140                 


Cys Val Gly Glu His Met Lys Asp Cys Leu Pro Asn Phe Val Thr Thr 
145                 150                 155                 160 


Asn Ser Cys Pro Leu Ala Ala Ser Thr Cys Tyr Ser Ser Thr Leu Lys 
                165                 170                 175     


Phe Gln Ala Gly Phe Leu Asn Thr Thr Phe Leu Leu Met Gly Cys Ala 
            180                 185                 190         


Arg Glu His Asn Gln Leu Leu Ala Asp Phe His His Ile Gly Ser Ile 
        195                 200                 205             


Lys Val Thr Glu Val Leu Asn Ile Leu Glu Lys Ser Gln Ile Val Gly 
    210                 215                 220                 


Ala Ala Ser Ser Arg Gln Asp Pro Ala Trp Gly Val Val Leu Gly Leu 
225                 230                 235                 240 


Leu Phe Ala Phe Arg Asp 
                245     


<210>  38
<211>  2845
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Leu Gly Lys Val Leu Ala Met Ala Leu Val Leu Ala Leu Ala 
1               5                   10                  15      


Val Leu Gly Ser Leu Ser Pro Gly Ala Arg Ala Gly Asp Cys Lys Gly 
            20                  25                  30          


Gln Arg Gln Val Leu Arg Glu Ala Pro Gly Phe Val Thr Asp Gly Ala 
        35                  40                  45              


Gly Asn Tyr Ser Val Asn Gly Asn Cys Glu Trp Leu Ile Glu Ala Pro 
    50                  55                  60                  


Ser Pro Gln His Arg Ile Leu Leu Asp Phe Leu Phe Leu Asp Thr Glu 
65                  70                  75                  80  


Cys Thr Tyr Asp Tyr Leu Phe Val Tyr Asp Gly Asp Ser Pro Arg Gly 
                85                  90                  95      


Pro Leu Leu Ala Ser Leu Ser Gly Ser Thr Arg Pro Pro Pro Ile Glu 
            100                 105                 110         


Ala Ser Ser Gly Lys Met Leu Leu His Leu Phe Ser Asp Ala Asn Tyr 
        115                 120                 125             


Asn Leu Leu Gly Phe Asn Ala Ser Phe Arg Phe Ser Leu Cys Pro Gly 
    130                 135                 140                 


Gly Cys Gln Ser His Gly Gln Cys Gln Pro Pro Gly Val Cys Ala Cys 
145                 150                 155                 160 


Glu Pro Gly Trp Gly Gly Pro Asp Cys Gly Leu Gln Glu Cys Ser Ala 
                165                 170                 175     


Tyr Cys Gly Ser His Gly Thr Cys Ala Ser Pro Leu Gly Pro Cys Arg 
            180                 185                 190         


Cys Glu Pro Gly Phe Leu Gly Arg Ala Cys Asp Leu His Leu Trp Glu 
        195                 200                 205             


Asn Gln Gly Ala Gly Trp Trp His Asn Val Ser Ala Arg Asp Pro Ala 
    210                 215                 220                 


Phe Ser Ala Arg Ile Gly Ala Ala Gly Ala Phe Leu Ser Pro Pro Gly 
225                 230                 235                 240 


Leu Leu Ala Val Phe Gly Gly Gln Asp Leu Asn Asn Ala Leu Gly Asp 
                245                 250                 255     


Leu Val Leu Tyr Asn Phe Ser Ala Asn Thr Trp Glu Ser Trp Asp Leu 
            260                 265                 270         


Ser Pro Ala Pro Ala Ala Arg His Ser His Val Ala Val Ala Trp Ala 
        275                 280                 285             


Gly Ser Leu Val Leu Met Gly Gly Glu Leu Ala Asp Gly Ser Leu Thr 
    290                 295                 300                 


Asn Asp Val Trp Ala Phe Ser Pro Leu Gly Arg Gly His Trp Glu Leu 
305                 310                 315                 320 


Leu Ala Pro Pro Ala Ser Ser Ser Ser Gly Pro Pro Gly Leu Ala Gly 
                325                 330                 335     


His Ala Ala Ala Leu Val Asp Asp Val Trp Leu Tyr Val Ser Gly Gly 
            340                 345                 350         


Arg Thr Pro His Asp Leu Phe Ser Ser Gly Leu Phe Arg Phe Arg Leu 
        355                 360                 365             


Asp Ser Thr Ser Gly Gly Tyr Trp Glu Gln Val Ile Pro Ala Gly Gly 
    370                 375                 380                 


Arg Pro Pro Ala Ala Thr Gly His Ser Met Val Phe His Ala Pro Ser 
385                 390                 395                 400 


Arg Ala Leu Leu Val His Gly Gly His Arg Pro Ser Thr Ala Arg Phe 
                405                 410                 415     


Ser Val Arg Val Asn Ser Thr Glu Leu Phe His Val Asp Arg His Val 
            420                 425                 430         


Trp Thr Thr Leu Lys Gly Arg Asp Gly Leu Gln Gly Pro Arg Glu Arg 
        435                 440                 445             


Ala Phe His Thr Ala Ser Val Leu Gly Asn Tyr Met Val Val Tyr Gly 
    450                 455                 460                 


Gly Asn Val His Thr His Tyr Gln Glu Glu Lys Cys Tyr Glu Asp Gly 
465                 470                 475                 480 


Ile Phe Phe Tyr His Leu Gly Cys His Gln Trp Val Ser Gly Ala Glu 
                485                 490                 495     


Leu Ala Pro Pro Gly Thr Pro Glu Gly Arg Ala Ala Pro Pro Ser Gly 
            500                 505                 510         


Arg Tyr Ser His Val Ala Ala Val Leu Gly Gly Ser Val Leu Leu Val 
        515                 520                 525             


Ala Gly Gly Tyr Ser Gly Arg Pro Arg Gly Asp Leu Met Ala Tyr Lys 
    530                 535                 540                 


Val Pro Pro Phe Val Phe Gln Ala Pro Ala Pro Asp Tyr His Leu Asp 
545                 550                 555                 560 


Tyr Cys Ser Met Tyr Thr Asp His Ser Val Cys Ser Arg Asp Pro Glu 
                565                 570                 575     


Cys Ser Trp Cys Gln Gly Ala Cys Gln Ala Ala Pro Pro Pro Gly Thr 
            580                 585                 590         


Pro Leu Gly Ala Cys Pro Ala Ala Ser Cys Leu Gly Leu Gly Arg Leu 
        595                 600                 605             


Leu Gly Asp Cys Gln Ala Cys Leu Ala Phe Ser Ser Pro Thr Ala Pro 
    610                 615                 620                 


Pro Arg Gly Pro Gly Thr Leu Gly Trp Cys Val His Asn Glu Ser Cys 
625                 630                 635                 640 


Leu Pro Arg Pro Glu Gln Ala Arg Cys Arg Gly Glu Gln Ile Ser Gly 
                645                 650                 655     


Thr Val Gly Trp Trp Gly Pro Ala Pro Val Phe Val Thr Ser Leu Glu 
            660                 665                 670         


Ala Cys Val Thr Gln Ser Phe Leu Pro Gly Leu His Leu Leu Thr Phe 
        675                 680                 685             


Gln Gln Pro Pro Asn Thr Ser Gln Pro Asp Lys Val Ser Ile Val Arg 
    690                 695                 700                 


Ser Thr Thr Ile Thr Leu Thr Pro Ser Ala Glu Thr Asp Val Ser Leu 
705                 710                 715                 720 


Val Tyr Arg Gly Phe Ile Tyr Pro Met Leu Pro Gly Gly Pro Gly Gly 
                725                 730                 735     


Pro Gly Ala Glu Asp Val Ala Val Trp Thr Arg Ala Gln Arg Leu His 
            740                 745                 750         


Val Leu Ala Arg Met Ala Arg Gly Pro Asp Thr Glu Asn Met Glu Glu 
        755                 760                 765             


Val Gly Arg Trp Val Ala His Gln Glu Lys Glu Thr Arg Arg Leu Gln 
    770                 775                 780                 


Arg Pro Gly Ser Ala Arg Leu Phe Pro Leu Pro Gly Arg Asp His Lys 
785                 790                 795                 800 


Tyr Ala Val Glu Ile Gln Gly Gln Leu Asn Gly Ser Ala Gly Pro Gly 
                805                 810                 815     


His Ser Glu Leu Thr Leu Leu Trp Asp Arg Thr Gly Val Pro Gly Gly 
            820                 825                 830         


Ser Glu Ile Ser Phe Phe Phe Leu Glu Pro Tyr Arg Ser Ser Ser Cys 
        835                 840                 845             


Thr Ser Tyr Ser Ser Cys Leu Gly Cys Leu Ala Asp Gln Gly Cys Gly 
    850                 855                 860                 


Trp Cys Leu Thr Ser Ala Thr Cys His Leu Arg Gln Gly Gly Ala His 
865                 870                 875                 880 


Cys Gly Asp Asp Gly Ala Gly Gly Ser Leu Leu Val Leu Val Pro Thr 
                885                 890                 895     


Leu Cys Pro Leu Cys Glu Glu His Arg Asp Cys His Ala Cys Thr Gln 
            900                 905                 910         


Asp Pro Phe Cys Glu Trp His Gln Ser Thr Ser Arg Lys Gly Asp Ala 
        915                 920                 925             


Ala Cys Ser Arg Arg Gly Arg Gly Arg Gly Ala Leu Lys Ser Pro Glu 
    930                 935                 940                 


Glu Cys Pro Pro Leu Cys Ser Gln Arg Leu Thr Cys Glu Asp Cys Leu 
945                 950                 955                 960 


Ala Asn Ser Ser Gln Cys Ala Trp Cys Gln Ser Thr His Thr Cys Phe 
                965                 970                 975     


Leu Phe Ala Ala Tyr Leu Ala Arg Tyr Pro His Gly Gly Cys Arg Gly 
            980                 985                 990         


Trp Asp Asp Ser Val His Ser Glu  Pro Arg Cys Arg Ser  Cys Asp Gly 
        995                 1000                 1005             


Phe Leu  Thr Cys His Glu Cys  Leu Gln Ser His Glu  Cys Gly Trp 
    1010                 1015                 1020             


Cys Gly  Asn Glu Asp Asn Pro  Thr Leu Gly Arg Cys  Leu Gln Gly 
    1025                 1030                 1035             


Asp Phe  Ser Gly Pro Leu Gly  Gly Gly Asn Cys Ser  Leu Trp Val 
    1040                 1045                 1050             


Gly Glu  Gly Leu Gly Leu Pro  Val Ala Leu Pro Ala  Arg Trp Ala 
    1055                 1060                 1065             


Tyr Ala  Arg Cys Pro Asp Val  Asp Glu Cys Arg Leu  Gly Leu Ala 
    1070                 1075                 1080             


Arg Cys  His Pro Arg Ala Thr  Cys Leu Asn Thr Pro  Leu Ser Tyr 
    1085                 1090                 1095             


Glu Cys  His Cys Gln Arg Gly  Tyr Gln Gly Asp Gly  Ile Ser His 
    1100                 1105                 1110             


Cys Asn  Arg Thr Cys Leu Glu  Asp Cys Gly His Gly  Val Cys Ser 
    1115                 1120                 1125             


Gly Pro  Pro Asp Phe Thr Cys  Val Cys Asp Leu Gly  Trp Thr Ser 
    1130                 1135                 1140             


Asp Leu  Pro Pro Pro Thr Pro  Ala Pro Gly Pro Pro  Ala Pro Arg 
    1145                 1150                 1155             


Cys Ser  Arg Asp Cys Gly Cys  Ser Phe His Ser His  Cys Arg Lys 
    1160                 1165                 1170             


Arg Gly  Pro Gly Phe Cys Asp  Glu Cys Gln Asp Trp  Thr Trp Gly 
    1175                 1180                 1185             


Glu His  Cys Glu Arg Cys Arg  Pro Gly Ser Phe Gly  Asn Ala Thr 
    1190                 1195                 1200             


Gly Ser  Arg Gly Cys Arg Pro  Cys Gln Cys Asn Gly  His Gly Asp 
    1205                 1210                 1215             


Pro Arg  Arg Gly His Cys Asp  Asn Leu Ser Gly Leu  Cys Phe Cys 
    1220                 1225                 1230             


Gln Asp  His Thr Glu Gly Ala  His Cys Gln Leu Cys  Ser Pro Gly 
    1235                 1240                 1245             


Tyr Tyr  Gly Asp Pro Arg Ala  Gly Gly Ser Cys Phe  Arg Glu Cys 
    1250                 1255                 1260             


Gly Gly  Arg Ala Leu Leu Thr  Asn Val Ser Ser Val  Ala Leu Gly 
    1265                 1270                 1275             


Ser Arg  Arg Val Gly Gly Leu  Leu Pro Pro Gly Gly  Gly Ala Ala 
    1280                 1285                 1290             


Arg Ala  Gly Pro Gly Leu Ser  Tyr Cys Val Trp Val  Val Ser Ala 
    1295                 1300                 1305             


Thr Glu  Glu Leu Gln Pro Cys  Ala Pro Gly Thr Leu  Cys Pro Pro 
    1310                 1315                 1320             


Leu Thr  Leu Thr Phe Ser Pro  Asp Ser Ser Thr Pro  Cys Thr Leu 
    1325                 1330                 1335             


Ser Tyr  Val Leu Ala Phe Asp  Gly Phe Pro Arg Phe  Leu Asp Thr 
    1340                 1345                 1350             


Gly Val  Val Gln Ser Asp Arg  Ser Leu Ile Ala Ala  Phe Cys Gly 
    1355                 1360                 1365             


Gln Arg  Arg Asp Arg Pro Leu  Thr Val Gln Ala Leu  Ser Gly Leu 
    1370                 1375                 1380             


Leu Val  Leu His Trp Glu Ala  Asn Gly Ser Ser Ser  Trp Gly Phe 
    1385                 1390                 1395             


Asn Ala  Ser Val Gly Ser Ala  Arg Cys Gly Ser Gly  Gly Pro Gly 
    1400                 1405                 1410             


Ser Cys  Pro Val Pro Gln Glu  Cys Val Pro Gln Asp  Gly Ala Ala 
    1415                 1420                 1425             


Gly Ala  Gly Leu Cys Arg Cys  Pro Gln Gly Trp Ala  Gly Pro His 
    1430                 1435                 1440             


Cys Arg  Met Ala Leu Cys Pro  Glu Asn Cys Asn Ala  His Thr Gly 
    1445                 1450                 1455             


Ala Gly  Thr Cys Asn Gln Ser  Leu Gly Val Cys Ile  Cys Ala Glu 
    1460                 1465                 1470             


Gly Phe  Gly Gly Pro Asp Cys  Ala Thr Lys Leu Asp  Gly Gly Gln 
    1475                 1480                 1485             


Leu Val  Trp Glu Thr Leu Met  Asp Ser Arg Leu Ser  Ala Asp Thr 
    1490                 1495                 1500             


Ala Ser  Arg Phe Leu His Arg  Leu Gly His Thr Met  Val Asp Gly 
    1505                 1510                 1515             


Pro Asp  Ala Thr Leu Trp Met  Phe Gly Gly Leu Gly  Leu Pro Gln 
    1520                 1525                 1530             


Gly Leu  Leu Gly Asn Leu Tyr  Arg Tyr Ser Val Ser  Glu Arg Arg 
    1535                 1540                 1545             


Trp Thr  Gln Met Leu Ala Gly  Ala Glu Asp Gly Gly  Pro Gly Pro 
    1550                 1555                 1560             


Ser Pro  Arg Ser Phe His Ala  Ala Ala Tyr Val Pro  Ala Gly Arg 
    1565                 1570                 1575             


Gly Ala  Met Tyr Leu Leu Gly  Gly Leu Thr Ala Gly  Gly Val Thr 
    1580                 1585                 1590             


Arg Asp  Phe Trp Val Leu Asn  Leu Thr Thr Leu Gln  Trp Arg Gln 
    1595                 1600                 1605             


Glu Lys  Ala Pro Gln Thr Val  Glu Leu Pro Ala Val  Ala Gly His 
    1610                 1615                 1620             


Thr Leu  Thr Ala Arg Arg Gly  Leu Ser Leu Leu Leu  Val Gly Gly 
    1625                 1630                 1635             


Tyr Ser  Pro Glu Asn Gly Phe  Asn Gln Gln Leu Leu  Glu Tyr Gln 
    1640                 1645                 1650             


Leu Ala  Thr Gly Thr Trp Val  Ser Gly Ala Gln Ser  Gly Thr Pro 
    1655                 1660                 1665             


Pro Thr  Gly Leu Tyr Gly His  Ser Ala Val Tyr His  Glu Ala Thr 
    1670                 1675                 1680             


Asp Ser  Leu Tyr Val Phe Gly  Gly Phe Arg Phe His  Val Glu Leu 
    1685                 1690                 1695             


Ala Ala  Pro Ser Pro Glu Leu  Tyr Ser Leu His Cys  Pro Asp Arg 
    1700                 1705                 1710             


Thr Trp  Ser Leu Leu Ala Pro  Ser Gln Gly Ala Lys  Arg Asp Arg 
    1715                 1720                 1725             


Met Arg  Asn Val Arg Gly Ser  Ser Arg Gly Leu Gly  Gln Val Pro 
    1730                 1735                 1740             


Gly Glu  Gln Pro Gly Ser Trp  Gly Phe Arg Glu Val  Arg Lys Lys 
    1745                 1750                 1755             


Met Ala  Leu Trp Ala Ala Leu  Ala Gly Thr Gly Gly  Phe Leu Glu 
    1760                 1765                 1770             


Glu Ile  Ser Pro His Leu Lys  Glu Pro Arg Pro Arg  Leu Phe His 
    1775                 1780                 1785             


Ala Ser  Ala Leu Leu Gly Asp  Thr Met Val Val Leu  Gly Gly Arg 
    1790                 1795                 1800             


Ser Asp  Pro Asp Glu Phe Ser  Ser Asp Val Leu Leu  Tyr Gln Val 
    1805                 1810                 1815             


Asn Cys  Asn Ala Trp Leu Leu  Pro Asp Leu Thr Arg  Ser Ala Ser 
    1820                 1825                 1830             


Val Gly  Pro Pro Met Glu Glu  Ser Val Ala His Ala  Val Ala Ala 
    1835                 1840                 1845             


Val Gly  Ser Arg Leu Tyr Ile  Ser Gly Gly Phe Gly  Gly Val Ala 
    1850                 1855                 1860             


Leu Gly  Arg Leu Leu Ala Leu  Thr Leu Pro Pro Asp  Pro Cys Arg 
    1865                 1870                 1875             


Leu Leu  Ser Ser Pro Glu Ala  Cys Asn Gln Ser Gly  Ala Cys Thr 
    1880                 1885                 1890             


Trp Cys  His Gly Ala Cys Leu  Ser Gly Asp Gln Ala  His Arg Leu 
    1895                 1900                 1905             


Gly Cys  Gly Gly Ser Pro Cys  Ser Pro Met Pro Arg  Ser Pro Glu 
    1910                 1915                 1920             


Glu Cys  Arg Arg Leu Arg Thr  Cys Ser Glu Cys Leu  Ala Arg His 
    1925                 1930                 1935             


Pro Arg  Thr Leu Gln Pro Gly  Asp Gly Glu Ala Ser  Thr Pro Arg 
    1940                 1945                 1950             


Cys Lys  Trp Cys Thr Asn Cys  Pro Glu Gly Ala Cys  Ile Gly Arg 
    1955                 1960                 1965             


Asn Gly  Ser Cys Thr Ser Glu  Asn Asp Cys Arg Ile  Asn Gln Arg 
    1970                 1975                 1980             


Glu Val  Phe Trp Ala Gly Asn  Cys Ser Glu Ala Ala  Cys Gly Ala 
    1985                 1990                 1995             


Ala Asp  Cys Glu Gln Cys Thr  Arg Glu Gly Lys Cys  Met Trp Thr 
    2000                 2005                 2010             


Arg Gln  Phe Lys Arg Thr Gly  Glu Thr Arg Arg Ile  Leu Ser Val 
    2015                 2020                 2025             


Gln Pro  Thr Tyr Asp Trp Thr  Cys Phe Ser His Ser  Leu Leu Asn 
    2030                 2035                 2040             


Val Ser  Pro Met Pro Val Glu  Ser Ser Pro Pro Leu  Pro Cys Pro 
    2045                 2050                 2055             


Thr Pro  Cys His Leu Leu Pro  Asn Cys Thr Ser Cys  Leu Asp Ser 
    2060                 2065                 2070             


Lys Gly  Ala Asp Gly Gly Trp  Gln His Cys Val Trp  Ser Ser Ser 
    2075                 2080                 2085             


Leu Gln  Gln Cys Leu Ser Pro  Ser Tyr Leu Pro Leu  Arg Cys Met 
    2090                 2095                 2100             


Ala Gly  Gly Cys Gly Arg Leu  Leu Arg Gly Pro Glu  Ser Cys Ser 
    2105                 2110                 2115             


Leu Gly  Cys Ala Gln Ala Thr  Gln Cys Ala Leu Cys  Leu Arg Arg 
    2120                 2125                 2130             


Pro His  Cys Gly Trp Cys Ala  Trp Gly Gly Gln Asp  Gly Gly Gly 
    2135                 2140                 2145             


Arg Cys  Met Glu Gly Gly Leu  Ser Gly Pro Arg Asp  Gly Leu Thr 
    2150                 2155                 2160             


Cys Gly  Arg Pro Gly Ala Ser  Trp Ala Phe Leu Ser  Cys Pro Pro 
    2165                 2170                 2175             


Glu Asp  Glu Cys Ala Asn Gly  His His Asp Cys Asn  Glu Thr Gln 
    2180                 2185                 2190             


Asn Cys  His Asp Gln Pro His  Gly Tyr Glu Cys Ser  Cys Lys Thr 
    2195                 2200                 2205             


Gly Tyr  Thr Met Asp Asn Met  Thr Gly Leu Cys Arg  Pro Val Cys 
    2210                 2215                 2220             


Ala Gln  Gly Cys Val Asn Gly  Ser Cys Val Glu Pro  Asp His Cys 
    2225                 2230                 2235             


Arg Cys  His Phe Gly Phe Val  Gly Arg Asn Cys Ser  Thr Glu Cys 
    2240                 2245                 2250             


Arg Cys  Asn Arg His Ser Glu  Cys Ala Gly Val Gly  Ala Arg Asp 
    2255                 2260                 2265             


His Cys  Leu Leu Cys Arg Asn  His Thr Lys Gly Ser  His Cys Glu 
    2270                 2275                 2280             


Gln Cys  Leu Pro Leu Phe Val  Gly Ser Ala Val Gly  Gly Gly Thr 
    2285                 2290                 2295             


Cys Arg  Pro Cys His Ala Phe  Cys Arg Gly Asn Ser  His Ile Cys 
    2300                 2305                 2310             


Ile Ser  Arg Lys Glu Leu Gln  Met Ser Lys Gly Glu  Pro Lys Lys 
    2315                 2320                 2325             


Tyr Ser  Leu Asp Pro Glu Glu  Ile Glu Asn Trp Val  Thr Glu Gly 
    2330                 2335                 2340             


Pro Ser  Glu Asp Glu Ala Val  Cys Val Asn Cys Gln  Asn Asn Ser 
    2345                 2350                 2355             


Tyr Gly  Glu Lys Cys Glu Ser  Cys Leu Gln Gly Tyr  Phe Leu Leu 
    2360                 2365                 2370             


Asp Gly  Lys Cys Thr Lys Cys  Gln Cys Asn Gly His  Ala Asp Thr 
    2375                 2380                 2385             


Cys Asn  Glu Gln Asp Gly Thr  Gly Cys Pro Cys Gln  Asn Asn Thr 
    2390                 2395                 2400             


Glu Thr  Gly Thr Cys Gln Gly  Ser Ser Pro Ser Asp  Arg Arg Asp 
    2405                 2410                 2415             


Cys Tyr  Lys Tyr Gln Cys Ala  Lys Cys Arg Glu Ser  Phe His Gly 
    2420                 2425                 2430             


Ser Pro  Leu Gly Gly Gln Gln  Cys Tyr Arg Leu Ile  Ser Val Glu 
    2435                 2440                 2445             


Gln Glu  Cys Cys Leu Asp Pro  Thr Ser Gln Thr Asn  Cys Phe His 
    2450                 2455                 2460             


Glu Pro  Lys Arg Arg Ala Leu  Gly Pro Gly Arg Thr  Val Leu Phe 
    2465                 2470                 2475             


Gly Val  Gln Pro Lys Phe Thr  Asn Val Asp Ile Arg  Leu Thr Leu 
    2480                 2485                 2490             


Asp Val  Thr Phe Gly Ala Val  Asp Leu Tyr Val Ser  Thr Ser Tyr 
    2495                 2500                 2505             


Asp Thr  Phe Val Val Arg Val  Ala Pro Asp Thr Gly  Val His Thr 
    2510                 2515                 2520             


Val His  Ile Gln Pro Pro Pro  Ala Pro Pro Pro Pro  Pro Pro Pro 
    2525                 2530                 2535             


Ala Asp  Gly Gly Pro Arg Gly  Ala Gly Asp Pro Gly  Gly Ala Gly 
    2540                 2545                 2550             


Ala Ser  Ser Gly Pro Gly Ala  Pro Ala Glu Pro Arg  Val Arg Glu 
    2555                 2560                 2565             


Val Trp  Pro Arg Gly Leu Ile  Thr Tyr Val Thr Val  Thr Glu Pro 
    2570                 2575                 2580             


Ser Ala  Val Leu Val Val Arg  Gly Val Arg Asp Arg  Leu Val Ile 
    2585                 2590                 2595             


Thr Tyr  Pro His Glu His His  Ala Leu Lys Ser Ser  Arg Phe Tyr 
    2600                 2605                 2610             


Leu Leu  Leu Leu Gly Val Gly  Asp Pro Ser Gly Pro  Gly Ala Asn 
    2615                 2620                 2625             


Gly Ser  Ala Asp Ser Gln Gly  Leu Leu Phe Phe Arg  Gln Asp Gln 
    2630                 2635                 2640             


Ala His  Ile Asp Leu Phe Val  Phe Phe Ser Val Phe  Phe Ser Cys 
    2645                 2650                 2655             


Phe Phe  Leu Phe Leu Ser Leu  Cys Val Leu Leu Trp  Lys Ala Lys 
    2660                 2665                 2670             


Gln Ala  Leu Asp Gln Arg Gln  Glu Gln Arg Arg His  Leu Gln Glu 
    2675                 2680                 2685             


Met Thr  Lys Met Ala Ser Arg  Pro Phe Ala Lys Val  Thr Val Cys 
    2690                 2695                 2700             


Phe Pro  Pro Asp Pro Thr Ala  Pro Ala Ser Ala Trp  Lys Pro Ala 
    2705                 2710                 2715             


Gly Leu  Pro Pro Pro Ala Phe  Arg Arg Ser Glu Pro  Phe Leu Ala 
    2720                 2725                 2730             


Pro Leu  Leu Leu Thr Gly Ala  Gly Gly Pro Trp Gly  Pro Met Gly 
    2735                 2740                 2745             


Gly Gly  Cys Cys Pro Pro Ala  Ile Pro Ala Thr Thr  Ala Gly Leu 
    2750                 2755                 2760             


Arg Ala  Gly Pro Ile Thr Leu  Glu Pro Thr Glu Asp  Gly Met Ala 
    2765                 2770                 2775             


Gly Val  Ala Thr Leu Leu Leu  Gln Leu Pro Gly Gly  Pro His Ala 
    2780                 2785                 2790             


Pro Asn  Gly Ala Cys Leu Gly  Ser Ala Leu Val Thr  Leu Arg His 
    2795                 2800                 2805             


Arg Leu  His Glu Tyr Cys Gly  Gly Gly Gly Gly Ala  Gly Gly Ser 
    2810                 2815                 2820             


Gly His  Gly Thr Gly Ala Gly  Arg Lys Gly Leu Leu  Ser Gln Asp 
    2825                 2830                 2835             


Asn Leu  Thr Ser Met Ser Leu  
    2840                 2845 


<210>  39
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Glu Gly Val Pro Ala Ser Pro Ser Ser Gly Glu Gly Ser Arg 
1               5                   10                  15      


Gly Pro His Ser Gly Val Ile Gln Trp Leu Val Asp Asn Phe Cys Ile 
            20                  25                  30          


Cys Glu Glu Cys Ser Val Pro Arg Cys Leu Met Tyr Glu Ile Tyr Val 
        35                  40                  45              


Glu Thr Cys Gly Gln Asn Thr Glu Asn Gln Val Asn Pro Ala Thr Phe 
    50                  55                  60                  


Gly Lys Leu Val Arg Leu Val Phe Pro Asp Leu Gly Thr Arg Arg Leu 
65                  70                  75                  80  


Gly Thr Arg Gly Ser Ala Arg Tyr His Tyr Asp Gly Ile Cys Ile Lys 
                85                  90                  95      


Lys Ser Ser Phe Phe Tyr Ala Gln Tyr Cys Tyr Leu Ile Gly Glu Lys 
            100                 105                 110         


Arg Tyr His Ser Gly Asp Ala Ile Ala Phe Glu Lys Ser Thr Asn Tyr 
        115                 120                 125             


Asn Ser Ile Ile Gln Gln Glu Ala Thr Cys Glu Asp His Ser Pro Met 
    130                 135                 140                 


Lys Thr Asp Pro Val Gly Ser Pro Leu Ser Glu Phe Arg Arg Cys Pro 
145                 150                 155                 160 


Phe Leu Glu Gln Glu Gln Ala Lys Lys Tyr Ser Cys Asn Met Met Ala 
                165                 170                 175     


Phe Leu Ala Asp Glu Tyr Cys Asn Tyr Cys Arg Asp Ile Leu Arg Asn 
            180                 185                 190         


Val Glu Asp Leu Leu Thr Ser Phe Trp Lys Ser Leu Gln Gln Asp Thr 
        195                 200                 205             


Val Met Leu Met Ser Leu Pro Asp Val Cys Gln Leu Phe Lys Cys Tyr 
    210                 215                 220                 


Asp Val Gln Leu Tyr Lys Gly Ile Glu Asp Val Leu Leu His Asp Phe 
225                 230                 235                 240 


Leu Glu Asp Val Ser Ile Gln Tyr Leu Lys Ser Val Gln Leu Phe Ser 
                245                 250                 255     


Lys Lys Phe Lys Leu Trp Leu Leu Asn Ala Leu Glu Gly Val Pro Ala 
            260                 265                 270         


Leu Leu Gln Ile Ser Lys Leu Lys Glu Val Thr Leu Phe Val Lys Arg 
        275                 280                 285             


Leu Arg Arg Lys Thr Tyr Leu Ser Asn Met Ala Lys Thr Met Arg Met 
    290                 295                 300                 


Val Leu Lys Ser Lys Arg Arg Val Ser Val Leu Lys Ser Asp Leu Gln 
305                 310                 315                 320 


Ala Ile Ile Asn Gln Gly Thr Leu Ala Thr Ser Lys Lys Ala Leu Ala 
                325                 330                 335     


Ser Asp Arg Ser Gly Ala Asp Glu Leu Glu Asn Asn Pro Glu Met Lys 
            340                 345                 350         


Cys Leu Arg Asn Leu Ile Ser Leu Leu Gly Thr Ser Thr Asp Leu Arg 
        355                 360                 365             


Val Phe Leu Ser Cys Leu Ser Ser His Leu Gln Ala Phe Val Phe Gln 
    370                 375                 380                 


Thr Ser Arg Ser Lys Glu Glu Phe Thr Lys Leu Ala Ala Ser Phe Gln 
385                 390                 395                 400 


Leu Arg Trp Asn Leu Leu Leu Thr Ala Val Ser Lys Ala Met Thr Leu 
                405                 410                 415     


Cys His Arg Asp Ser Phe Gly Ser Trp His Leu Phe His Leu Leu Leu 
            420                 425                 430         


Leu Glu Tyr Met Ile His Ile Leu Gln Ser Cys Leu Glu Glu Glu Glu 
        435                 440                 445             


Glu Glu Glu Asp Met Gly Thr Val Lys Glu Met Leu Pro Asp Asp Pro 
    450                 455                 460                 


Thr Leu Gly Gln Pro Asp Gln Ala Leu Phe His Ser Leu Asn Ser Ser 
465                 470                 475                 480 


Leu Ser Gln Ala Cys Ala Ser Pro Ser Met Glu Pro Leu Gly Val Met 
                485                 490                 495     


Pro Thr His Met Gly Gln Gly Arg Tyr Pro Val Gly Val Ser Asn Met 
            500                 505                 510         


Val Leu Arg Ile Leu Gly Phe Leu Val Asp Thr Ala Met Gly Asn Lys 
        515                 520                 525             


Leu Ile Gln Val Leu Leu Glu Asp Glu Thr Thr Glu Ser Ala Val Lys 
    530                 535                 540                 


Leu Ser Leu Pro Met Gly Gln Glu Ala Leu Ile Thr Leu Lys Asp Gly 
545                 550                 555                 560 


Gln Gln Phe Val Ile Gln Ile Ser Asp Val Pro Gln Ser Ser Glu Asp 
                565                 570                 575     


Ile Tyr Phe Arg Glu Asn Asn Ala Asn Val 
            580                 585     


<210>  40
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 
1               5                   10                  15      


Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 
            20                  25                  30          


Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 
        35                  40                  45              


His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 
    50                  55                  60                  


Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 
65                  70                  75                  80  


Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 
                85                  90                  95      


Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 
            100                 105                 110         


Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 
        115                 120                 125             


Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 
    130                 135                 140                 


Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 
145                 150                 155                 160 


Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 
                165                 170                 175     


Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 
            180                 185                 190         


Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 
        195                 200                 205             


Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 
    210                 215                 220                 


Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 
225                 230                 235                 240 


Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 
                245                 250                 255     


Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 
            260                 265                 270         


Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 
        275                 280                 285             


Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 
    290                 295                 300                 


Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 
                325                 330                 335     


Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 
            340                 345                 350         


Thr Ile Thr Pro Leu Met Phe Thr Gly Tyr Gly Leu Leu Phe Leu Ser 
        355                 360                 365             


Leu Val Ile Thr Pro Val Ile Arg Ala Lys Leu Ser Lys Leu Val Arg 
    370                 375                 380                 


Glu Thr Glu Gln Gly Ala Leu Phe Ser Ala Val Ala Cys Val Asn Ser 
385                 390                 395                 400 


Leu Ala Met Leu Thr Ala Ser Gly Ile Phe Asn Ser Leu Tyr Pro Ala 
                405                 410                 415     


Thr Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu Gly Ala Gly Leu 
            420                 425                 430         


Leu Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu Lys Ala Asp Pro 
        435                 440                 445             


His Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 
    450                 455                 


<210>  41
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  41

Met His Trp Lys Met Leu Leu Leu Leu Leu Leu Tyr Tyr Asn Ala Glu 
1               5                   10                  15      


Ala Ser Met Cys His Arg Trp Ser Arg Ala Val Leu Phe Pro Ala Ala 
            20                  25                  30          


His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln 
        35                  40                  45              


Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu 
    50                  55                  60                  


Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu 
65                  70                  75                  80  


Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val 
                85                  90                  95      


Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser 
            100                 105                 110         


Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu 
        115                 120                 125             


Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln 
    130                 135                 140                 


Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg 
145                 150                 155                 160 


His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro 
                165                 170             


<210>  42
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Thr Leu Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro 
1               5                   10                  15      


Ser Phe Pro Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu 
            20                  25                  30          


Thr Thr Gln Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu 
        35                  40                  45              


Leu Arg Arg Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu 
    50                  55                  60                  


Trp Asn Lys Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys 
65                  70                  75                  80  


Asn Tyr Arg His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys 
                85                  90                  95      


Gly Glu Asn Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala 
            100                 105                 110         


Ile Gln Ser Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly 
        115                 120                 125             


Pro Lys Thr Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp 
    130                 135                 140                 


Tyr Ser Ser Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln 
145                 150                 155                 160 


Lys Val Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn 
                165                 170                 175     


Trp Ala Asn Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala 
            180                 185                 190         


Ser Cys Pro Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys 
        195                 200                 205             


Tyr Glu Asp Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr 
    210                 215                 220                 


Cys Lys His Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr 
                245 


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide

<400>  43

Lys Lys Ser Arg Gly Asp Tyr Met Thr Met Gln Ile Gly 
1               5                   10              


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide

<400>  44

Gly Gly Met Glu Asp Ile Tyr Phe Glu Phe Met Gly Gly Lys Lys Lys 
1               5                   10                  15      


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide

<400>  45

Lys Lys Lys Gly Gln Glu Glu Glu Tyr Val Phe Ile Glu 
1               5                   10              


