                               SEQUENCE LISTING

<110> Genentech, Inc.
 
<120> COMPOSITIONS AND METHODS OF USE

<130> 50474-177WO3

<150> US 62/697,372 
<151> 2018-07-12

<150> US 62/622,704 
<151> 2018-01-26

<160> 84    

<170> PatentIn version 3.5

<210> 1
<211> 495
<212> DNA
<213> Homo sapiens

<220>
<223> Human IL-22 

<400> 1
atgggatggt catgtatcat cctttttcta gtagcaactg caactggagt acattcagcg       60

cccatcagct cccactgcag gcttgacaag tccaacttcc agcagcccta tatcaccaac      120

cgcaccttca tgctggctaa ggaggctagc ttggctgata acaacacaga cgttcgtctc      180

attggggaga aactgttcca cggagtcagt atgagtgagc gctgctatct gatgaagcag      240

gtgctgaact tcacccttga agaagtgctg ttccctcaat ctgataggtt ccagccttat      300

atgcaggagg tggtgccctt cctggccagg ctcagcaaca ggctaagcac atgtcatatt      360

gaaggtgatg acctgcatat ccagaggaat gtgcaaaagc tgaaggacac agtgaaaaag      420

cttggagaga gtggagagat caaagcaatt ggagaactgg atttgctgtt tatgtctctg      480

agaaatgcct gcatt                                                       495


<210> 2
<211> 165
<212> PRT
<213> Homo sapiens

<220>
<223> Human IL-22 

<400> 2
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn 
            20                  25                  30          


Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu 
        35                  40                  45              


Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys 
    50                  55                  60                  


Leu Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln 
65                  70                  75                  80  


Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg 
                85                  90                  95      


Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser 
            100                 105                 110         


Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln 
        115                 120                 125             


Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser 
    130                 135                 140                 


Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu 
145                 150                 155                 160 


Arg Asn Ala Cys Ile 
                165 


<210> 3
<211> 438
<212> DNA
<213> Homo sapiens

<220>
<223> IL-22 DNA (mature)

<400> 3
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcatt                                                    438


<210> 4
<211> 146
<212> PRT
<213> Homo sapiens

<220>
<223> IL-22 (mature)

<400> 4
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210> 5
<211> 57
<212> DNA
<213> Homo sapiens

<220>
<223> IL-22 leader sequence

<400> 5
atgggatggt catgtatcat cctttttcta gtagcaactg caactggagt acattca          57


<210> 6
<211> 19
<212> PRT
<213> Homo sapiens

<220>
<223> IL-22 leader sequence

<400> 6
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 7
<211> 1128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG4 (minus C-terminal Lys) N297G

<400> 7
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattcg cgttgagtcc aaatatggtc ccccatgccc accatgccca      480

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      540

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      600

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      660

ccgcgggagg agcagttcgg aagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      720

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc      780

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc      840

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      900

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      960

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1020

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1080

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggt                  1128


<210> 8
<211> 376
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG4 (minus C-terminal Lys) N297G

<400> 8
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Leu Gly 
    370                 375     


<210> 9
<211> 1128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG4 (minus C-terminal Lys) N297A

<400> 9
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattcg cgttgagtcc aaatatggtc ccccatgccc accatgccca      480

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      540

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      600

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      660

ccgcgggagg agcagttcgc tagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      720

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc      780

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc      840

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      900

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      960

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1020

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1080

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggt                  1128


<210> 10
<211> 376
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG4 (minus C-terminal Lys) N297A

<400> 10
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Leu Gly 
    370                 375     


<210> 11
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG1 (minus C-terminal Lys) N297G

<400> 11
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattga gcccaaatct agtgacaaaa ctcacacatg cccaccgtgc      480

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta cggaagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga agagatgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg t              1131


<210> 12
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG1 (minus C-terminal Lys) N297G

<400> 12
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375         


<210> 13
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG1 (minus C-terminal Lys) N297A

<400> 13
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattga gcccaaatct agtgacaaaa ctcacacatg cccaccgtgc      480

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta cgctagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga agagatgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg t              1131


<210> 14
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG1 (minus C-terminal Lys) N297A

<400> 14
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375         


<210> 15
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG4 (full) N297G

<400> 15
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattcg cgttgagtcc aaatatggtc ccccatgccc accatgccca      480

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      540

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      600

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      660

ccgcgggagg agcagttcgg aagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      720

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc      780

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc      840

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      900

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      960

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1020

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1080

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa a              1131


<210> 16
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG4 (full) N297G

<400> 16
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    370                 375         


<210> 17
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG4 (full) N297A

<400> 17
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattcg cgttgagtcc aaatatggtc ccccatgccc accatgccca      480

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      540

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      600

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      660

ccgcgggagg agcagttcgc tagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      720

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc      780

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc      840

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      900

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      960

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1020

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1080

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa a              1131


<210> 18
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG4 (full) N297A

<400> 18
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    370                 375         


<210> 19
<211> 1134
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG1 (full) N297G

<400> 19
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattga gcccaaatct agtgacaaaa ctcacacatg cccaccgtgc      480

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta cggaagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga agagatgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1134


<210> 20
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG1 (full) N297G

<400> 20
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375             


<210> 21
<211> 1134
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG1 (full) N297A

<400> 21
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattga gcccaaatct agtgacaaaa ctcacacatg cccaccgtgc      480

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta cgctagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga agagatgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1134


<210> 22
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG1 (full) N297A

<400> 22
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375             


<210> 23
<211> 1128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG4 (wt N297, minus Lys)

<400> 23
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattcg cgttgagtcc aaatatggtc ccccatgccc accatgccca      480

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      540

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      600

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      660

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      720

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc      780

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc      840

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      900

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      960

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1020

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1080

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggt                  1128


<210> 24
<211> 376
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG4 (wt N297, minus Lys)

<400> 24
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Leu Gly 
    370                 375     


<210> 25
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG1 (wt N297, minus Lys)

<400> 25
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattga gcccaaatct agtgacaaaa ctcacacatg cccaccgtgc      480

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga agagatgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg t              1131


<210> 26
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG1 (wt N297, minus Lys)

<400> 26
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375         


<210> 27
<211> 1131
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG4 (N297 wt)

<400> 27
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattcg cgttgagtcc aaatatggtc ccccatgccc accatgccca      480

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      540

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      600

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      660

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      720

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc      780

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc      840

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      900

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      960

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1020

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1080

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa a              1131


<210> 28
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG4 (N297 wt)

<400> 28
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    370                 375         


<210> 29
<211> 1134
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> IL-22 Fc fusion IgG1 (N297 wt)

<400> 29
gcgcccatca gctcccactg caggcttgac aagtccaact tccagcagcc ctatatcacc       60

aaccgcacct tcatgctggc taaggaggct agcttggctg ataacaacac agacgttcgt      120

ctcattgggg agaaactgtt ccacggagtc agtatgagtg agcgctgcta tctgatgaag      180

caggtgctga acttcaccct tgaagaagtg ctgttccctc aatctgatag gttccagcct      240

tatatgcagg aggtggtgcc cttcctggcc aggctcagca acaggctaag cacatgtcat      300

attgaaggtg atgacctgca tatccagagg aatgtgcaaa agctgaagga cacagtgaaa      360

aagcttggag agagtggaga gatcaaagca attggagaac tggatttgct gtttatgtct      420

ctgagaaatg cctgcattga gcccaaatct agtgacaaaa ctcacacatg cccaccgtgc      480

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga agagatgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1134


<210> 30
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG1 (N297 wt)

<400> 30
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375             


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      hinge peptide

<400> 31
Cys Pro Pro Cys Pro 
1               5           


<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 32
Asp Lys Thr His Thr 
1               5   


<210> 33
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 33
Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210> 34
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 34
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10      


<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 35
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10          


<210> 36
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 36
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10              


<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 37
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10                  


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 38
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15  


<210> 39
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 39
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15      


<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 40
Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10  


<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 41
Gly Gly Gly Asp Lys Thr His Thr 
1               5               


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker (IgG3) peptide

<400> 42
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210> 43
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 43
Ser Lys Tyr Gly Pro Pro 
1               5       


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 44
Arg Val Glu Ser Lys Tyr Gly Pro Pro 
1               5                   


<210> 45
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 45
Gly Gly Ser 
1           


<210> 46
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 46
Gly Gly Gly Ser 
1               


<210> 47
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 47
Gly Gly Gly Gly Ser 
1               5   


<210> 48
<211> 146
<212> PRT
<213> Pan troglodytes

<400> 48
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Ser Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Asn Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210> 49
<211> 146
<212> PRT
<213> Pongo abelii

<400> 49
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe Arg 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210> 50
<211> 146
<212> PRT
<213> Mus musculus

<400> 50
Leu Pro Val Asn Thr Arg Cys Lys Leu Glu Val Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Val Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe Arg 
        35                  40                  45              


Gly Val Ser Ala Lys Asp Gln Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Asp Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Thr Lys Leu Ser Asn Gln Leu 
                85                  90                  95      


Ser Ser Cys His Ile Ser Gly Asp Asp Gln Asn Ile Gln Lys Asn Val 
            100                 105                 110         


Arg Arg Leu Lys Glu Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Val 
145     


<210> 51
<211> 146
<212> PRT
<213> Canis familiaris

<400> 51
Leu Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Asn Met Gly Glu Arg Cys Tyr Leu Met Lys Glu Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Lys Leu 
                85                  90                  95      


Ser Gln Cys His Ile Glu Asn Asp Asp Gln His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Gln Lys Leu Gly Glu Asn Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ala Leu Arg Asn Ala 
    130                 135                 140                 


Cys Val 
145     


<210> 52
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IL-22 Fc fusion protein IgG1 forward primer

<400> 52
ttgaattcca ccatgggatg gtcatgtatc atcctttttc tagtagcaac tgcaactgga       60

gtacattcag cgcccatcag ctcccactgc aggc                                   94


<210> 53
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IL-22 Fc fusion IgG1 reverse primer

<400> 53
aggtcgactc atttacccgg agacagggag agg                                    33


<210> 54
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IL-22 Fc fusion IgG4 forward primer

<400> 54
ttgaattcca ccatgggatg gtcatgtatc atcctttttc tagtagcaac tgcaactgga       60

gtacattcag cgcccatcag ctcccactgc aggc                                   94


<210> 55
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IL-22 Fc fusion IgG4 reverse primer

<400> 55
aggtcgactt atttacccag agacagggag agg                                    33


<210> 56
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 N297G forward primer

<400> 56
gcgggaggag cagtacggaa gcacgtaccg tgtgg                                  35


<210> 57
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 N297G reverse primer

<400> 57
ccacacggta cgtgcttccg tactgctcct cccgc                                  35


<210> 58
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG4 N297G forward primer

<400> 58
acaaagccgc gggaggagca gttcggaagc acgtaccgtg tggtcagcgt c                51


<210> 59
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG4 N297G reverse primer

<400> 59
gacgctgacc acacggtacg tgcttccgaa ctgctcctcc cgcggctttg t                51


<210> 60
<211> 411
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 Fc fusion IgG2a

<400> 60
Met Ala Val Leu Gln Lys Ser Met Ser Phe Ser Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Ala Ser Cys Leu Leu Leu Ile Ala Leu Trp Ala Gln Glu Ala Asn 
            20                  25                  30          


Ala Leu Pro Val Asn Thr Arg Cys Lys Leu Glu Val Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Val Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


Arg Gly Val Ser Ala Lys Asp Gln Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Asp Val Leu Leu Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Thr Lys Leu Ser Asn Gln 
        115                 120                 125             


Leu Ser Ser Cys His Ile Ser Gly Asp Asp Gln Asn Ile Gln Lys Asn 
    130                 135                 140                 


Val Arg Arg Leu Lys Glu Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Val Ala Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
            180                 185                 190         


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        195                 200                 205             


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
225                 230                 235                 240 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
                245                 250                 255     


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
            260                 265                 270         


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
        275                 280                 285             


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
    290                 295                 300                 


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
305                 310                 315                 320 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
                325                 330                 335     


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
            340                 345                 350         


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
        355                 360                 365             


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
    370                 375                 380                 


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
385                 390                 395                 400 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                405                 410     


<210> 61
<211> 372
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IL-22 IgG1 fusion knob (T366W) minus Lys

<400> 61
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            180                 185                 190         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        195                 200                 205             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    210                 215                 220                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                245                 250                 255     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            260                 265                 270         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        275                 280                 285             


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    290                 295                 300                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
305                 310                 315                 320 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                325                 330                 335     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        355                 360                 365             


Leu Ser Pro Gly 
    370         


<210> 62
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Monomeric Fc hole

<400> 62
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 63
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 63
Gly Gly Gly Ser Thr His Thr 
1               5           


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 64
Asp Lys Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10                  


<210> 65
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 65
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10                  15      


<210> 66
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 66
Lys Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10              


<210> 67
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 67
Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10      


<210> 68
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 68
Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10          


<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 69
Val Asp Lys Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
1               5                   10                  15  


<210>  70
<211>  1152
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(597)

<400>  70
cttcagaaca ggttctcctt ccccagtcac cagttgctcg agttagaatt gtctgca          57

atg gcc gcc ctg cag aaa tct gtg agc tct ttc ctt atg ggg acc ctg        105
Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu           
1               5                   10                  15                

gcc acc agc tgc ctc ctt ctc ttg gcc ctc ttg gta cag gga gga gca        153
Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala           
            20                  25                  30                    

gct gcg ccc atc agc tcc cac tgc agg ctt gac aag tcc aac ttc cag        201
Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln           
        35                  40                  45                        

cag ccc tat atc acc aac cgc acc ttc atg ctg gct aag gag gct agc        249
Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser           
    50                  55                  60                            

ttg gct gat aac aac aca gac gtt cgt ctc att ggg gag aaa ctg ttc        297
Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe           
65                  70                  75                  80            

cac gga gtc agt atg agt gag cgc tgc tat ctg atg aag cag gtg ctg        345
His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu           
                85                  90                  95                

aac ttc acc ctt gaa gaa gtg ctg ttc cct caa tct gat agg ttc cag        393
Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln           
            100                 105                 110                   

cct tat atg cag gag gtg gtg ccc ttc ctg gcc agg ctc agc aac agg        441
Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg           
        115                 120                 125                       

cta agc aca tgt cat att gaa ggt gat gac ctg cat atc cag agg aat        489
Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn           
    130                 135                 140                           

gtg caa aag ctg aag gac aca gtg aaa aag ctt gga gag agt gga gag        537
Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu           
145                 150                 155                 160           

atc aaa gca att gga gaa ctg gat ttg ctg ttt atg tct ctg aga aat        585
Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn           
                165                 170                 175               

gcc tgc att tga ccagagcaaa gctgaaaaat gaataactaa ccccctttcc            637
Ala Cys Ile                                                               
                                                                          

ctgctagaaa taacaattag atgccccaaa gcgatttttt ttaaccaaaa ggaagatggg      697

aagccaaact ccatcatgat gggtggattc caaatgaacc cctgcgttag ttacaaagga      757

aaccaatgcc acttttgttt ataagaccag aaggtagact ttctaagcat agatatttat      817

tgataacatt tcattgtaac tggtgttcta tacacagaaa acaatttatt ttttaaataa      877

ttgtcttttt ccataaaaaa gattactttc cattccttta ggggaaaaaa cccctaaata      937

gcttcatgtt tccataatca gtactttata tttataaatg tatttattat tattataaga      997

ctgcatttta tttatatcat tttattaata tggatttatt tatagaaaca tcattcgata     1057

ttgctacttg agtgtaaggc taatattgat atttatgaca ataattatag agctataaca     1117

tgtttatttg acctcaataa acacttggat atccc                                1152


<210>  71
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  71
Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  72
<211>  1236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72
atggctgtcc tgcagaaatc tatgagtttt tcccttatgg ggactttggc cgccagctgc       60

ctgcttctca ttgccctgtg ggcccaggag gcaaatgcgc tgcccgtcaa cacccggtgc      120

aagcttgagg tgtccaactt ccagcagcca tacatcgtca accgcacctt tatgctggcc      180

aaggaggcca gccttgcaga taacaacaca gatgtccggc tcatcgggga gaaactgttc      240

cgaggagtca gtgctaagga tcagtgctac ctgatgaagc aggtgctcaa cttcaccctg      300

gaagacgttc tgctccccca gtcagacagg ttccagccct acatgcagga ggtggtgcct      360

ttcctgacca aactcagcaa tcagctcagc tcctgtcaca tcagcggtga cgaccagaac      420

atccagaaga atgtcagaag gctgaaggag acagtgaaaa agcttggaga gagtggagag      480

atcaaggcga ttggggaact ggacctgctg tttatgtctc tgagaaatgc ttgcgtcgct      540

cgaggaccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcttgggt      600

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      660

cccatagtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc      720

tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac      780

aacagtactc tacgcgtggt cagtgccctc cccatccagc accaggactg gatgagtggc      840

aaggagttca aatgcaaggt caacaacaaa gacctcccag cgcccatcga gagaaccatc      900

tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa      960

gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac     1020

atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca     1080

gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac     1140

tgggtggaaa gaaatagcta ctcctgttca gtggtccacg agggtctgca caatcaccac     1200

acgactaaga gcttctcccg gactccgggt aaatga                               1236


<210>  73
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Met Ala Val Leu Gln Lys Ser Met Ser Phe Ser Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Ala Ser Cys Leu Leu Leu Ile Ala Leu Trp Ala Gln Glu Ala Asn 
            20                  25                  30          


Ala Leu Pro Val Asn Thr Arg Cys Lys Leu Glu Val Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Val Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


Arg Gly Val Ser Ala Lys Asp Gln Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Asp Val Leu Leu Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Thr Lys Leu Ser Asn Gln 
        115                 120                 125             


Leu Ser Ser Cys His Ile Ser Gly Asp Asp Gln Asn Ile Gln Lys Asn 
    130                 135                 140                 


Val Arg Arg Leu Lys Glu Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Val Ala Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
            180                 185                 190         


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        195                 200                 205             


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
225                 230                 235                 240 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
                245                 250                 255     


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
            260                 265                 270         


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
        275                 280                 285             


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
    290                 295                 300                 


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
305                 310                 315                 320 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
                325                 330                 335     


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
            340                 345                 350         


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
        355                 360                 365             


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
    370                 375                 380                 


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
385                 390                 395                 400 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                405                 410     


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  74
aggtccattc agatgctggt                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  75
taggtgtggt tgacgtggag                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  76
ccaccccaca ctcacaccgg                                                   20


<210>  77
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
        115                 120                 125             


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
    130                 135                 140                 


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
145                 150                 155                 160 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Ser Ser 
                165                 170                 175     


Ala 


<210>  78
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  79
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr 
            100                 105                 110         


Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg 
        115                 120                 125             


Thr Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn 
    130                 135                 140                 


Phe Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met 
145                 150                 155                 160 


Phe Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg 
                165                 170                 175     


Ala Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly 
            180                 185                 190         


Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205         


<210>  80
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Leu Val Asn Phe Ile Leu Arg Cys Gly Leu Leu Leu Val Thr Leu 
1               5                   10                  15      


Ser Leu Ala Ile Ala Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys 
            20                  25                  30          


Tyr Pro Arg Gly Thr Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys 
        35                  40                  45              


Ala Ala Trp Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile 
    50                  55                  60                  


Arg Leu Leu Lys Lys Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln 
65                  70                  75                  80  


Phe Gln Glu Gln Leu Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln 
                85                  90                  95      


Leu Gln Leu Gln Gly Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His 
            100                 105                 110         


Ser Leu Arg Gln Lys Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala 
        115                 120                 125             


Arg Glu Met Lys Ser Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile 
    130                 135                 140                 


Gly Asn Lys Gly Ile Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu 
145                 150                 155                 160 


Ser Trp Ile Lys Lys Leu Leu Glu Ser Ser Gln 
                165                 170    


<210>  81
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His 
1               5                   10                  15      


Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser 
            20                  25                  30          


Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr 
        35                  40                  45              


Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp 
    50                  55                  60                  


Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn 
65                  70                  75                  80  


Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val 
                85                  90                  95      


Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg 
            100                 105                 110         


Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys 
        115                 120                 125             


Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr 
    130                 135                 140                 


Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe 
145                 150                 155                 160 


His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln 
                165                 170                 175     


Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr 
            180                 185                 190         


Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp 
        195                 200                 205             


Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro Asp 
    210                 215                 220                 


Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly 
225                 230                 235                 240 


Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr Lys 
                245                 250                 255     


Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr Phe 
            260                 265                 270         


Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe Asp 
        275                 280                 285             


Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln Ile 
    290                 295                 300                 


Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His Ser 
305                 310                 315                 320 


Leu Ser Glu Ile Thr Tyr Leu Gly Gln Pro Asp Ile Ser Ile Leu Gln 
                325                 330                 335     


Pro Ser Asn Val Pro Pro Pro Gln Ile Leu Ser Pro Leu Ser Tyr Ala 
            340                 345                 350         


Pro Asn Ala Ala Pro Glu Val Gly Pro Pro Ser Tyr Ala Pro Gln Val 
        355                 360                 365             


Thr Pro Glu Ala Gln Phe Pro Phe Tyr Ala Pro Gln Ala Ile Ser Lys 
    370                 375                 380                 


Val Gln Pro Ser Ser Tyr Ala Pro Gln Ala Thr Pro Asp Ser Trp Pro 
385                 390                 395                 400 


Pro Ser Tyr Gly Val Cys Met Glu Gly Ser Gly Lys Asp Ser Pro Thr 
                405                 410                 415     


Gly Thr Leu Ser Ser Pro Lys His Leu Arg Pro Lys Gly Gln Leu Gln 
            420                 425                 430         


Lys Glu Pro Pro Ala Gly Ser Cys Met Leu Gly Gly Leu Ser Leu Gln 
        435                 440                 445             


Glu Val Thr Ser Leu Ala Met Glu Glu Ser Gln Glu Ala Lys Ser Leu 
    450                 455                 460                 


His Gln Pro Leu Gly Ile Cys Thr Asp Arg Thr Ser Asp Pro Asn Val 
465                 470                 475                 480 


Leu His Ser Gly Glu Glu Gly Thr Pro Gln Tyr Leu Lys Gly Gln Leu 
                485                 490                 495     


Pro Leu Leu Ser Ser Val Gln Ile Glu Gly His Pro Met Ser Leu Pro 
            500                 505                 510         


Leu Gln Pro Pro Ser Arg Pro Cys Ser Pro Ser Asp Gln Gly Pro Ser 
        515                 520                 525             


Pro Trp Gly Leu Leu Glu Ser Leu Val Cys Pro Lys Asp Glu Ala Lys 
    530                 535                 540                 


Ser Pro Ala Pro Glu Thr Ser Asp Leu Glu Gln Pro Thr Glu Leu Asp 
545                 550                 555                 560 


Ser Leu Phe Arg Gly Leu Ala Leu Thr Val Gln Trp Glu Ser 
                565                 570                 


<210>  82
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  82

His Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln 
1               5                   10                  15      


Ser Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly 
            20                  25                  30          


Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg 
        35                  40                  45              


Asp Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys 
    50                  55                  60                  


Asn Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg 
65                  70                  75                  80  


Val Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp 
                85                  90                  95      


Arg Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr 
            100                 105                 110         


Cys Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro 
        115                 120                 125             


Thr Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile 
    130                 135                 140                 


Phe His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr 
145                 150                 155                 160 


Gln Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu 
                165                 170                 175     


Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr 
            180                 185                 190         


Trp Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro 
        195                 200                 205             


Asp Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met 
    210                 215                 220                 


Gly Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr 
225                 230                 235                 240 


Lys Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr 
                245                 250                 255     


Phe Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe 
            260                 265                 270         


Asp Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln 
        275                 280                 285             


Ile Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His 
    290                 295                 300                 


Ser Leu Ser Glu Ile Thr Tyr Leu Gly Gln Pro Asp Ile Ser Ile Leu 
305                 310                 315                 320 


Gln Pro Ser Asn Val Pro Pro Pro Gln Ile Leu Ser Pro Leu Ser Tyr 
                325                 330                 335     


Ala Pro Asn Ala Ala Pro Glu Val Gly Pro Pro Ser Tyr Ala Pro Gln 
            340                 345                 350         


Val Thr Pro Glu Ala Gln Phe Pro Phe Tyr Ala Pro Gln Ala Ile Ser 
        355                 360                 365             


Lys Val Gln Pro Ser Ser Tyr Ala Pro Gln Ala Thr Pro Asp Ser Trp 
    370                 375                 380                 


Pro Pro Ser Tyr Gly Val Cys Met Glu Gly Ser Gly Lys Asp Ser Pro 
385                 390                 395                 400 


Thr Gly Thr Leu Ser Ser Pro Lys His Leu Arg Pro Lys Gly Gln Leu 
                405                 410                 415     


Gln Lys Glu Pro Pro Ala Gly Ser Cys Met Leu Gly Gly Leu Ser Leu 
            420                 425                 430         


Gln Glu Val Thr Ser Leu Ala Met Glu Glu Ser Gln Glu Ala Lys Ser 
        435                 440                 445             


Leu His Gln Pro Leu Gly Ile Cys Thr Asp Arg Thr Ser Asp Pro Asn 
    450                 455                 460                 


Val Leu His Ser Gly Glu Glu Gly Thr Pro Gln Tyr Leu Lys Gly Gln 
465                 470                 475                 480 


Leu Pro Leu Leu Ser Ser Val Gln Ile Glu Gly His Pro Met Ser Leu 
                485                 490                 495     


Pro Leu Gln Pro Pro Ser Arg Pro Cys Ser Pro Ser Asp Gln Gly Pro 
            500                 505                 510         


Ser Pro Trp Gly Leu Leu Glu Ser Leu Val Cys Pro Lys Asp Glu Ala 
        515                 520                 525             


Lys Ser Pro Ala Pro Glu Thr Ser Asp Leu Glu Gln Pro Thr Glu Leu 
    530                 535                 540                 


Asp Ser Leu Phe Arg Gly Leu Ala Leu Thr Val Gln Trp Glu Ser 
545                 550                 555                 


<210>  83
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala 
    210                 215                 220                 


Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Cys Phe Ala Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe 
                245                 250                 255     


Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His 
            260                 265                 270         


Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu 
        275                 280                 285             


Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser 
    290                 295                 300                 


Gly Lys Gln Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly 
305                 310                 315                 320 


Gln Gly Pro Gln Ser 
                325 


<210>  84
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val Asn Phe Lys 
1               5                   10                  15      


Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly Asn Leu Thr 
            20                  25                  30          


Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp Lys Cys Met 
        35                  40                  45              


Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser Lys Tyr Gly 
    50                  55                  60                  


Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu His Ser Asp 
65                  70                  75                  80  


Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile Ile Gly Pro 
                85                  90                  95      


Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His Met Arg Phe 
            100                 105                 110         


Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr Met Lys Asn 
        115                 120                 125             


Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys Asn Gly Thr 
    130                 135                 140                 


Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu Val Leu Arg 
145                 150                 155                 160 


Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg Gly Phe Leu 
                165                 170                 175     


Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val Cys Glu Gln 
            180                 185                 190         


Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala Val Ile Leu 
        195                 200                 205             


Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly Cys Phe Ala 
    210                 215                 220                 


Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe Ser Pro Arg 
225                 230                 235                 240 


Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His Pro His His 
                245                 250                 255     


Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu Asn Asp Val 
            260                 265                 270         


Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser Gly Lys Gln 
        275                 280                 285             


Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly Gln Gly Pro 
    290                 295                 300                 


Gln Ser 
305     




