                         SEQUENCE LISTING

<110>  EPITOPIX, LLC
 
<120>  ENGINEERED PROTEINS AND METHODS OF USE

<130>  0293.000055WO01

<140>  PCT/US19/15164
<141>  2019-01-25

<150>  62/621,796
<151>  2018-01-25

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  148
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein

<400>  1

Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg Ala Pro Leu Tyr 
1               5                   10                  15      


Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp Tyr Lys Gly Arg 
            20                  25                  30          


Gly Glu Ser Arg Gln Leu Gln Leu Ile Thr Gln Tyr Tyr Lys Ser Gln 
        35                  40                  45              


Ser Gln Gly Asp Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly Phe Ser 
    50                  55                  60                  


Ala Ile Ser Gly Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu Asn Ser 
65                  70                  75                  80  


Asp Arg Ile Pro Gly Thr Glu Arg Asp Pro Phe Asn Ile Asp His Ile 
                85                  90                  95      


Glu Val Ile Ser Gly Ala Thr Asp Glu Ser Leu Arg Phe Tyr Pro Phe 
            100                 105                 110         


Pro Thr Val Asn Ala Asn Lys Gln Ala Thr Ala Phe Ser Ser Ser Gln 
        115                 120                 125             


Gln Asp Thr Asp Gln Val Ala Gln Gln Asn Asp Asp Asn Glu Ile Ile 
    130                 135                 140                 


Val Ser Ala Ser 
145             


<210>  2
<211>  101
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein

<400>  2

Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn His Trp Asp Leu 
1               5                   10                  15      


Asn Tyr Glu Ser Arg Lys Pro Gly Ile Ser Ile Thr Gly Gly Asn Glu 
            20                  25                  30          


Lys Pro Asp Ile Ser Ile Lys Asn Asn Gln Val His Thr Leu Thr Pro 
        35                  40                  45              


Gly Glu Ser Leu Asp Ala Trp Thr Met Arg Gly Asn Leu Lys Gln Pro 
    50                  55                  60                  


Asn Ser Lys Arg Glu Thr His Asn Ser Arg Ser Glu Lys Val Ile Arg 
65                  70                  75                  80  


Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Gln Glu His Gly Lys Phe 
                85                  90                  95      


Gly Asn Ser Thr Thr 
            100     


<210>  3
<211>  153
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein


<220>
<221>  MISC_FEATURE
<222>  (1)..(138)
<223>  Xaa can be an optional linker

<400>  3

Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg Ala Pro Leu Tyr 
1               5                   10                  15      


Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp Tyr Lys Gly Arg 
            20                  25                  30          


Gly Xaa Glu Ser Arg Gln Leu Gln Leu Ile Thr Gln Tyr Tyr Lys Ser 
        35                  40                  45              


Gln Xaa Ser Gln Gly Asp Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly 
    50                  55                  60                  


Phe Ser Ala Ile Ser Gly Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu 
65                  70                  75                  80  


Asn Ser Asp Arg Ile Pro Gly Thr Glu Arg Xaa Asp Pro Phe Asn Ile 
                85                  90                  95      


Asp His Ile Glu Val Ile Ser Gly Ala Thr Xaa Asp Glu Ser Leu Arg 
            100                 105                 110         


Phe Tyr Pro Phe Pro Thr Val Asn Ala Asn Lys Gln Ala Thr Ala Phe 
        115                 120                 125             


Ser Ser Ser Gln Gln Asp Thr Asp Gln Xaa Val Ala Gln Gln Asn Asp 
    130                 135                 140                 


Asp Asn Glu Ile Ile Val Ser Ala Ser 
145                 150             


<210>  4
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein


<220>
<221>  MISC_FEATURE
<222>  (1)..(94)
<223>  Xaa can be an optional linker

<400>  4

Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn His Trp Asp Leu 
1               5                   10                  15      


Asn Tyr Glu Ser Arg Lys Pro Xaa Gly Ile Ser Ile Thr Gly Gly Asn 
            20                  25                  30          


Glu Lys Pro Asp Ile Ser Ile Xaa Lys Asn Asn Gln Val His Thr Leu 
        35                  40                  45              


Thr Pro Gly Glu Ser Leu Asp Ala Trp Thr Met Arg Gly Asn Leu Lys 
    50                  55                  60                  


Gln Pro Asn Ser Lys Arg Glu Thr His Asn Ser Arg Ser Xaa Glu Lys 
65                  70                  75                  80  


Val Ile Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Xaa Gln Glu 
                85                  90                  95      


His Gly Lys Phe Gly Asn Ser Thr Thr 
            100                 105 


<210>  5
<211>  461
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein


<220>
<221>  MISC_FEATURE
<222>  (1)..(446)
<223>  Xaa can be an optional linker

<400>  5

Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg Ala Pro Leu Tyr 
1               5                   10                  15      


Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp Tyr Lys Gly Arg 
            20                  25                  30          


Gly Xaa Glu Ser Arg Gln Leu Gln Leu Ile Thr Gln Tyr Tyr Lys Ser 
        35                  40                  45              


Gln Xaa Ser Gln Gly Asp Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly 
    50                  55                  60                  


Phe Ser Ala Ile Ser Gly Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu 
65                  70                  75                  80  


Asn Ser Asp Arg Ile Pro Gly Thr Glu Arg Xaa Asp Pro Phe Asn Ile 
                85                  90                  95      


Asp His Ile Glu Val Ile Ser Gly Ala Thr Xaa Asp Glu Ser Leu Arg 
            100                 105                 110         


Phe Tyr Pro Phe Pro Thr Val Asn Ala Asn Lys Gln Ala Thr Ala Phe 
        115                 120                 125             


Ser Ser Ser Gln Gln Asp Thr Asp Gln Xaa Val Ala Gln Gln Asn Asp 
    130                 135                 140                 


Asp Asn Glu Ile Ile Val Ser Ala Ser Xaa Phe Asp Arg Asp Tyr Thr 
145                 150                 155                 160 


Thr Val Trp Gly Gln Arg Ala Pro Leu Tyr Tyr Ser Pro Gly Tyr Gly 
                165                 170                 175     


Pro Ala Ser Leu Tyr Asp Tyr Lys Gly Arg Gly Xaa Glu Ser Arg Gln 
            180                 185                 190         


Leu Gln Leu Ile Thr Gln Tyr Tyr Lys Ser Gln Xaa Ser Gln Gly Asp 
        195                 200                 205             


Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly Phe Ser Ala Ile Ser Gly 
    210                 215                 220                 


Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu Asn Ser Asp Arg Ile Pro 
225                 230                 235                 240 


Gly Thr Glu Arg Xaa Asp Pro Phe Asn Ile Asp His Ile Glu Val Ile 
                245                 250                 255     


Ser Gly Ala Thr Xaa Asp Glu Ser Leu Arg Phe Tyr Pro Phe Pro Thr 
            260                 265                 270         


Val Asn Ala Asn Lys Gln Ala Thr Ala Phe Ser Ser Ser Gln Gln Asp 
        275                 280                 285             


Thr Asp Gln Xaa Val Ala Gln Gln Asn Asp Asp Asn Glu Ile Ile Val 
    290                 295                 300                 


Ser Ala Ser Xaa Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg 
305                 310                 315                 320 


Ala Pro Leu Tyr Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp 
                325                 330                 335     


Tyr Lys Gly Arg Gly Xaa Glu Ser Arg Gln Leu Gln Leu Ile Thr Gln 
            340                 345                 350         


Tyr Tyr Lys Ser Gln Xaa Ser Gln Gly Asp Asp Asn Tyr Gly Leu Asn 
        355                 360                 365             


Leu Gly Lys Gly Phe Ser Ala Ile Ser Gly Ser Ser Thr Pro Tyr Val 
    370                 375                 380                 


Ser Lys Gly Leu Asn Ser Asp Arg Ile Pro Gly Thr Glu Arg Xaa Asp 
385                 390                 395                 400 


Pro Phe Asn Ile Asp His Ile Glu Val Ile Ser Gly Ala Thr Xaa Asp 
                405                 410                 415     


Glu Ser Leu Arg Phe Tyr Pro Phe Pro Thr Val Asn Ala Asn Lys Gln 
            420                 425                 430         


Ala Thr Ala Phe Ser Ser Ser Gln Gln Asp Thr Asp Gln Xaa Val Ala 
        435                 440                 445             


Gln Gln Asn Asp Asp Asn Glu Ile Ile Val Ser Ala Ser 
    450                 455                 460     


<210>  6
<211>  317
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein


<220>
<221>  MISC_FEATURE
<222>  (1)..(306)
<223>  Xaa can be an optional linker

<400>  6

Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn His Trp Asp Leu 
1               5                   10                  15      


Asn Tyr Glu Ser Arg Lys Pro Xaa Gly Ile Ser Ile Thr Gly Gly Asn 
            20                  25                  30          


Glu Lys Pro Asp Ile Ser Ile Xaa Lys Asn Asn Gln Val His Thr Leu 
        35                  40                  45              


Thr Pro Gly Glu Ser Leu Asp Ala Trp Thr Met Arg Gly Asn Leu Lys 
    50                  55                  60                  


Gln Pro Asn Ser Lys Arg Glu Thr His Asn Ser Arg Ser Xaa Glu Lys 
65                  70                  75                  80  


Val Ile Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Xaa Gln Glu 
                85                  90                  95      


His Gly Lys Phe Gly Asn Ser Thr Thr Xaa Arg Glu Val Lys Ser Gly 
            100                 105                 110         


Lys Lys Asp Lys Tyr Asn His Trp Asp Leu Asn Tyr Glu Ser Arg Lys 
        115                 120                 125             


Pro Xaa Gly Ile Ser Ile Thr Gly Gly Asn Glu Lys Pro Asp Ile Ser 
    130                 135                 140                 


Ile Xaa Lys Asn Asn Gln Val His Thr Leu Thr Pro Gly Glu Ser Leu 
145                 150                 155                 160 


Asp Ala Trp Thr Met Arg Gly Asn Leu Lys Gln Pro Asn Ser Lys Arg 
                165                 170                 175     


Glu Thr His Asn Ser Arg Ser Xaa Glu Lys Val Ile Arg Glu Val Lys 
            180                 185                 190         


Ser Gly Lys Lys Asp Lys Tyr Xaa Gln Glu His Gly Lys Phe Gly Asn 
        195                 200                 205             


Ser Thr Thr Xaa Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn 
    210                 215                 220                 


His Trp Asp Leu Asn Tyr Glu Ser Arg Lys Pro Xaa Gly Ile Ser Ile 
225                 230                 235                 240 


Thr Gly Gly Asn Glu Lys Pro Asp Ile Ser Ile Xaa Lys Asn Asn Gln 
                245                 250                 255     


Val His Thr Leu Thr Pro Gly Glu Ser Leu Asp Ala Trp Thr Met Arg 
            260                 265                 270         


Gly Asn Leu Lys Gln Pro Asn Ser Lys Arg Glu Thr His Asn Ser Arg 
        275                 280                 285             


Ser Xaa Glu Lys Val Ile Arg Glu Val Lys Ser Gly Lys Lys Asp Lys 
    290                 295                 300                 


Tyr Xaa Gln Glu His Gly Lys Phe Gly Asn Ser Thr Thr 
305                 310                 315         


<210>  7
<211>  1557
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding a MoLE Protein

<400>  7
catcatcacc atcaccattt cgatcgtgat tataccaccg tttggggtca gcgtgcaccg       60

ctgtattata gtccgggtta tggtccggca agcctgtatg attataaagg tcgtggtggt      120

agcggtagcg aaagccgtca gctgcaactg attacccagt attacaaaag ccagggtagc      180

ggcagcagcc agggtgatga taattatggt ctgaatctgg gtaaaggctt tagcgcaatt      240

agcggtagta gcaccccgta tgttagcaaa ggtctgaata gtgatcgtat tccgggtaca      300

gaacgtggtt caggtagcga tccgtttaac attgatcata ttgaagttat tagcggtgca      360

accggtagcg gttcagatga aagcctgcgt ttttatccgt ttccgaccgt taatgcaaat      420

aaacaggcaa ccgcatttag cagcagtcag caggataccg atcagggtag tggtagcgtt      480

gcacagcaga atgatgataa cgaaattatt gttagcgcaa gcggcagcgg tagctttgat      540

cgcgattaca caacagtgtg gggacaacgt gcccctctgt actattcacc tggttatggc      600

cctgcatcac tgtatgacta caaaggacgc ggaggttcag gttcagaaag tcgtcaactg      660

cagctgatca cacaatacta taaaagtcag ggttctggta gctcacaggg cgacgataac      720

tacggcctga acctgggcaa aggtttttct gcaattagtg gttcaagtac accgtatgtg      780

tcaaaaggcc tgaactcaga tcgcattcct ggcaccgaac gcggtagtgg cagtgatccg      840

ttcaatatcg accatatcga agtgatttca ggtgccaccg gttcaggcag tgatgagagt      900

ctgcgcttct atccttttcc tacagtgaac gccaacaaac aggccacagc ctttagctca      960

agccagcagg acacagacca gggttcaggc tcagtggccc agcagaacga cgataatgag     1020

atcattgtga gcgcctcagg cagcggttct tttgaccgcg actatacgac ggtatggggt     1080

caacgcgctc cactgtatta cagccctggc tacggtcctg ccagtctgta cgattacaaa     1140

ggccgtggcg gaagtggtag tgaatcacgc caactgcaac tgatcacgca gtactacaaa     1200

tcacagggct caggtagtag tcagggtgac gacaactatg gcctgaatct ggggaaagga     1260

ttctctgcca tttcaggcag ctcaacgccg tatgtgagta aaggactgaa cagcgaccgc     1320

attccgggaa ccgagcgtgg cagtggttca gaccctttca acatcgatca cattgaggtg     1380

atctctggtg cgaccggctc tggctcagat gaatcactgc gcttttaccc attcccgaca     1440

gtaaatgcga acaaacaagc gaccgccttt tcaagctcac agcaagatac agatcaaggc     1500

tctggttctg tagcccaaca aaatgatgac aatgaaatca tcgtttccgc cagctaa        1557


<210>  8
<211>  518
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein

<400>  8

His His His His His His Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly 
1               5                   10                  15      


Gln Arg Ala Pro Leu Tyr Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu 
            20                  25                  30          


Tyr Asp Tyr Lys Gly Arg Gly Gly Ser Gly Ser Glu Ser Arg Gln Leu 
        35                  40                  45              


Gln Leu Ile Thr Gln Tyr Tyr Lys Ser Gln Gly Ser Gly Ser Ser Gln 
    50                  55                  60                  


Gly Asp Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly Phe Ser Ala Ile 
65                  70                  75                  80  


Ser Gly Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu Asn Ser Asp Arg 
                85                  90                  95      


Ile Pro Gly Thr Glu Arg Gly Ser Gly Ser Asp Pro Phe Asn Ile Asp 
            100                 105                 110         


His Ile Glu Val Ile Ser Gly Ala Thr Gly Ser Gly Ser Asp Glu Ser 
        115                 120                 125             


Leu Arg Phe Tyr Pro Phe Pro Thr Val Asn Ala Asn Lys Gln Ala Thr 
    130                 135                 140                 


Ala Phe Ser Ser Ser Gln Gln Asp Thr Asp Gln Gly Ser Gly Ser Val 
145                 150                 155                 160 


Ala Gln Gln Asn Asp Asp Asn Glu Ile Ile Val Ser Ala Ser Gly Ser 
                165                 170                 175     


Gly Ser Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg Ala Pro 
            180                 185                 190         


Leu Tyr Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp Tyr Lys 
        195                 200                 205             


Gly Arg Gly Gly Ser Gly Ser Glu Ser Arg Gln Leu Gln Leu Ile Thr 
    210                 215                 220                 


Gln Tyr Tyr Lys Ser Gln Gly Ser Gly Ser Ser Gln Gly Asp Asp Asn 
225                 230                 235                 240 


Tyr Gly Leu Asn Leu Gly Lys Gly Phe Ser Ala Ile Ser Gly Ser Ser 
                245                 250                 255     


Thr Pro Tyr Val Ser Lys Gly Leu Asn Ser Asp Arg Ile Pro Gly Thr 
            260                 265                 270         


Glu Arg Gly Ser Gly Ser Asp Pro Phe Asn Ile Asp His Ile Glu Val 
        275                 280                 285             


Ile Ser Gly Ala Thr Gly Ser Gly Ser Asp Glu Ser Leu Arg Phe Tyr 
    290                 295                 300                 


Pro Phe Pro Thr Val Asn Ala Asn Lys Gln Ala Thr Ala Phe Ser Ser 
305                 310                 315                 320 


Ser Gln Gln Asp Thr Asp Gln Gly Ser Gly Ser Val Ala Gln Gln Asn 
                325                 330                 335     


Asp Asp Asn Glu Ile Ile Val Ser Ala Ser Gly Ser Gly Ser Phe Asp 
            340                 345                 350         


Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg Ala Pro Leu Tyr Tyr Ser 
        355                 360                 365             


Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp Tyr Lys Gly Arg Gly Gly 
    370                 375                 380                 


Ser Gly Ser Glu Ser Arg Gln Leu Gln Leu Ile Thr Gln Tyr Tyr Lys 
385                 390                 395                 400 


Ser Gln Gly Ser Gly Ser Ser Gln Gly Asp Asp Asn Tyr Gly Leu Asn 
                405                 410                 415     


Leu Gly Lys Gly Phe Ser Ala Ile Ser Gly Ser Ser Thr Pro Tyr Val 
            420                 425                 430         


Ser Lys Gly Leu Asn Ser Asp Arg Ile Pro Gly Thr Glu Arg Gly Ser 
        435                 440                 445             


Gly Ser Asp Pro Phe Asn Ile Asp His Ile Glu Val Ile Ser Gly Ala 
    450                 455                 460                 


Thr Gly Ser Gly Ser Asp Glu Ser Leu Arg Phe Tyr Pro Phe Pro Thr 
465                 470                 475                 480 


Val Asn Ala Asn Lys Gln Ala Thr Ala Phe Ser Ser Ser Gln Gln Asp 
                485                 490                 495     


Thr Asp Gln Gly Ser Gly Ser Val Ala Gln Gln Asn Asp Asp Asn Glu 
            500                 505                 510         


Ile Ile Val Ser Ala Ser 
        515             


<210>  9
<211>  1098
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding a MoLE Protein

<400>  9
caccaccacc accaccaccg tgaagttaaa agcggcaaaa aagataaata caaccactgg       60

gatctgaact atgaaagccg taaaccgggt agcggtagtg gtattagcat taccggtggt      120

aatgaaaaac cggatattag tattggtagc ggcagcaaaa ataaccaggt tcataccctg      180

acaccgggtg aaagcctgga tgcatggacc atgcgtggta atctgaaaca gccgaatagc      240

aaacgtgaaa cccataatag ccgtagcggt tcaggtagcg aaaaagttat tcgtgaagtg      300

aaatcgggta aaaaagacaa atatggcagc ggtagccaag aacatggtaa atttggtaat      360

agcaccaccg gttctggtag tcgcgaagtg aaaagtggaa aaaaagacaa atataaccat      420

tgggacctga attacgaatc acgcaaaccg ggttcaggtt caggcatttc aattacaggt      480

ggcaacgaga aaccagatat cagcattggc tctggtagca aaaacaatca ggtgcacaca      540

ctgacccctg gtgaatcact ggacgcctgg acaatgcgtg gcaacctgaa acaacctaat      600

tcaaaacgcg aaacgcataa ctcacgtagt ggttctggtt cagaaaaagt gatccgcgag      660

gttaaatcag ggaaaaaaga taaatatggg tccggctcac aagaacacgg caaattcggc      720

aattcaacca ccggcagtgg ttcacgtgag gtgaaatctg gcaaaaaaga caaatacaat      780

cattgggacc tgaactatga gtctcgtaaa cctggttctg gcagcggcat tagtattaca      840

ggcggaaacg aaaaacctga catttctatt ggttccggct caaaaaacaa ccaagtacat      900

acgctgaccc caggcgagag tctggatgcg tggacgatgc gtggaaacct gaaacagcca      960

aactctaaac gtgagacaca taacagtcgc agcggcagcg gctctgagaa agtaattcgg     1020

gaagtaaaat ccggaaaaaa agataaatac ggttcgggca gccaagagca cggaaaattt     1080

ggcaacagta ccacctaa                                                   1098


<210>  10
<211>  365
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein

<400>  10

His His His His His His Arg Glu Val Lys Ser Gly Lys Lys Asp Lys 
1               5                   10                  15      


Tyr Asn His Trp Asp Leu Asn Tyr Glu Ser Arg Lys Pro Gly Ser Gly 
            20                  25                  30          


Ser Gly Ile Ser Ile Thr Gly Gly Asn Glu Lys Pro Asp Ile Ser Ile 
        35                  40                  45              


Gly Ser Gly Ser Lys Asn Asn Gln Val His Thr Leu Thr Pro Gly Glu 
    50                  55                  60                  


Ser Leu Asp Ala Trp Thr Met Arg Gly Asn Leu Lys Gln Pro Asn Ser 
65                  70                  75                  80  


Lys Arg Glu Thr His Asn Ser Arg Ser Gly Ser Gly Ser Glu Lys Val 
                85                  90                  95      


Ile Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Gly Ser Gly Ser 
            100                 105                 110         


Gln Glu His Gly Lys Phe Gly Asn Ser Thr Thr Gly Ser Gly Ser Arg 
        115                 120                 125             


Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn His Trp Asp Leu Asn 
    130                 135                 140                 


Tyr Glu Ser Arg Lys Pro Gly Ser Gly Ser Gly Ile Ser Ile Thr Gly 
145                 150                 155                 160 


Gly Asn Glu Lys Pro Asp Ile Ser Ile Gly Ser Gly Ser Lys Asn Asn 
                165                 170                 175     


Gln Val His Thr Leu Thr Pro Gly Glu Ser Leu Asp Ala Trp Thr Met 
            180                 185                 190         


Arg Gly Asn Leu Lys Gln Pro Asn Ser Lys Arg Glu Thr His Asn Ser 
        195                 200                 205             


Arg Ser Gly Ser Gly Ser Glu Lys Val Ile Arg Glu Val Lys Ser Gly 
    210                 215                 220                 


Lys Lys Asp Lys Tyr Gly Ser Gly Ser Gln Glu His Gly Lys Phe Gly 
225                 230                 235                 240 


Asn Ser Thr Thr Gly Ser Gly Ser Arg Glu Val Lys Ser Gly Lys Lys 
                245                 250                 255     


Asp Lys Tyr Asn His Trp Asp Leu Asn Tyr Glu Ser Arg Lys Pro Gly 
            260                 265                 270         


Ser Gly Ser Gly Ile Ser Ile Thr Gly Gly Asn Glu Lys Pro Asp Ile 
        275                 280                 285             


Ser Ile Gly Ser Gly Ser Lys Asn Asn Gln Val His Thr Leu Thr Pro 
    290                 295                 300                 


Gly Glu Ser Leu Asp Ala Trp Thr Met Arg Gly Asn Leu Lys Gln Pro 
305                 310                 315                 320 


Asn Ser Lys Arg Glu Thr His Asn Ser Arg Ser Gly Ser Gly Ser Glu 
                325                 330                 335     


Lys Val Ile Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Gly Ser 
            340                 345                 350         


Gly Ser Gln Glu His Gly Lys Phe Gly Asn Ser Thr Thr 
        355                 360                 365 


<210>  11

<400>  11
000

<210>  12
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  B cell domain

<400>  12

Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg Ala Pro Leu Tyr 
1               5                   10                  15      


Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp Tyr Lys Gly Arg 
            20                  25                  30          


Gly 
    


<210>  13
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  B cell domain

<400>  13

Ser Gln Gly Asp Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly Phe Ser 
1               5                   10                  15      


Ala Ile Ser Gly Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu Asn Ser 
            20                  25                  30          


Asp Arg Ile Pro Gly Thr Glu Arg 
        35                  40  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  B cell domain

<400>  14

Asp Glu Ser Leu Arg Phe Tyr Pro Phe Pro Thr Val Asn Ala Asn Lys 
1               5                   10                  15      


Gln Ala Thr Ala Phe Ser Ser Ser Gln Gln Asp Thr Asp Gln 
            20                  25                  30  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  T cell domain

<400>  15

Glu Ser Arg Gln Leu Gln Leu Ile Thr Gln Tyr Tyr Lys Ser Gln 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  T cell domain

<400>  16

Asp Pro Phe Asn Ile Asp His Ile Glu Val Ile Ser Gly Ala Thr 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  T cell domain

<400>  17

Val Ala Gln Gln Asn Asp Asp Asn Glu Ile Ile Val Ser Ala Ser 
1               5                   10                  15  


<210>  18
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  B cell domain

<400>  18

Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn His Trp Asp Leu 
1               5                   10                  15      


Asn Tyr Glu Ser Arg Lys Pro 
            20              


<210>  19
<211>  37
<212>  PRT
<213>  Artificial

<220>
<223>  B cell domain

<400>  19

Lys Asn Asn Gln Val His Thr Leu Thr Pro Gly Glu Ser Leu Asp Ala 
1               5                   10                  15      


Trp Thr Met Arg Gly Asn Leu Lys Gln Pro Asn Ser Lys Arg Glu Thr 
            20                  25                  30          


His Asn Ser Arg Ser 
        35          


<210>  20
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  B cell domain

<400>  20

Gln Glu His Gly Lys Phe Gly Asn Ser Thr Thr 
1               5                   10      


<210>  21
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  T cell domain

<400>  21

Gly Ile Ser Ile Thr Gly Gly Asn Glu Lys Pro Asp Ile Ser Ile 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  T cell domain

<400>  22

Glu Lys Val Ile Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr 
1               5                   10                  15  


<210>  23
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  23

Gly Ser Gly Ser 
1               


<210>  24
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  24

Gly Pro Gly Pro Gly 
1               5   


<210>  25
<211>  1269
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding a MoLE Protein

<400>  25
catcatcacc atcaccatcg tgaagttaaa agcggcaaaa aagataaata caaccactgg       60

gatctgaact atgaaagccg taaaccgggt agcggtagcg aaagccgtca gctgcaactg      120

attacccagt attacaaaag ccagggtagc ggcagcaaaa ataaccaggt tcataccctg      180

acaccgggtg aaagcctgga tgcatggacc atgcgtggta atctgaaaca gccgaatagc      240

aaacgtgaaa cccataatag ccgtagcggt tcaggtagcg atccgtttaa cattgatcat      300

attgaagtta ttagcggtgc aaccggtagc ggttcacaag aacatggtaa atttggtaat      360

agcaccaccg gtagtggtag cgttgcacag cagaatgatg ataacgaaat tattgttagc      420

gcaagcggca gcggtagccg cgaagtgaaa agtggaaaaa aagacaaata taaccattgg      480

gacctgaatt acgaatcacg caaaccgggt tcaggttcag aaagtcgtca actgcagctg      540

atcacacaat actataaaag tcagggttct ggtagcaaaa acaatcaggt gcacacactg      600

acccctggtg aatcactgga cgcctggaca atgcgtggca acctgaaaca acctaattca      660

aaacgcgaaa cgcataactc acgtagtggt agtggcagtg atccgttcaa tatcgaccat      720

atcgaagtga tttcaggtgc caccggttca ggcagtcaag aacacggcaa attcggcaat      780

tcaaccaccg gttcaggctc agtggcccag cagaacgacg ataatgagat cattgtgagc      840

gcctcaggca gcggttctcg tgaggtgaaa tctggcaaaa aagacaaata caatcattgg      900

gacctgaact atgagtctcg taaacctgga agtggtagtg aatcacgcca actgcaactg      960

atcacgcagt actacaaatc acagggctca ggtagtaaaa acaaccaagt acatacgctg     1020

accccaggcg agagtctgga tgcgtggacg atgcgtggaa acctgaaaca gccaaactct     1080

aaacgtgaga cacataacag tcgcagcggc agtggttcag accctttcaa catcgatcac     1140

attgaggtga tctctggtgc gaccggctct ggctcacaag agcacggaaa atttggcaac     1200

agtaccaccg gctctggttc tgtagcccaa caaaatgatg acaatgaaat catcgtttcc     1260

gccagctaa                                                             1269


<210>  26
<211>  422
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein

<400>  26

His His His His His His Arg Glu Val Lys Ser Gly Lys Lys Asp Lys 
1               5                   10                  15      


Tyr Asn His Trp Asp Leu Asn Tyr Glu Ser Arg Lys Pro Gly Ser Gly 
            20                  25                  30          


Ser Glu Ser Arg Gln Leu Gln Leu Ile Thr Gln Tyr Tyr Lys Ser Gln 
        35                  40                  45              


Gly Ser Gly Ser Lys Asn Asn Gln Val His Thr Leu Thr Pro Gly Glu 
    50                  55                  60                  


Ser Leu Asp Ala Trp Thr Met Arg Gly Asn Leu Lys Gln Pro Asn Ser 
65                  70                  75                  80  


Lys Arg Glu Thr His Asn Ser Arg Ser Gly Ser Gly Ser Asp Pro Phe 
                85                  90                  95      


Asn Ile Asp His Ile Glu Val Ile Ser Gly Ala Thr Gly Ser Gly Ser 
            100                 105                 110         


Gln Glu His Gly Lys Phe Gly Asn Ser Thr Thr Gly Ser Gly Ser Val 
        115                 120                 125             


Ala Gln Gln Asn Asp Asp Asn Glu Ile Ile Val Ser Ala Ser Gly Ser 
    130                 135                 140                 


Gly Ser Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn His Trp 
145                 150                 155                 160 


Asp Leu Asn Tyr Glu Ser Arg Lys Pro Gly Ser Gly Ser Glu Ser Arg 
                165                 170                 175     


Gln Leu Gln Leu Ile Thr Gln Tyr Tyr Lys Ser Gln Gly Ser Gly Ser 
            180                 185                 190         


Lys Asn Asn Gln Val His Thr Leu Thr Pro Gly Glu Ser Leu Asp Ala 
        195                 200                 205             


Trp Thr Met Arg Gly Asn Leu Lys Gln Pro Asn Ser Lys Arg Glu Thr 
    210                 215                 220                 


His Asn Ser Arg Ser Gly Ser Gly Ser Asp Pro Phe Asn Ile Asp His 
225                 230                 235                 240 


Ile Glu Val Ile Ser Gly Ala Thr Gly Ser Gly Ser Gln Glu His Gly 
                245                 250                 255     


Lys Phe Gly Asn Ser Thr Thr Gly Ser Gly Ser Val Ala Gln Gln Asn 
            260                 265                 270         


Asp Asp Asn Glu Ile Ile Val Ser Ala Ser Gly Ser Gly Ser Arg Glu 
        275                 280                 285             


Val Lys Ser Gly Lys Lys Asp Lys Tyr Asn His Trp Asp Leu Asn Tyr 
    290                 295                 300                 


Glu Ser Arg Lys Pro Gly Ser Gly Ser Glu Ser Arg Gln Leu Gln Leu 
305                 310                 315                 320 


Ile Thr Gln Tyr Tyr Lys Ser Gln Gly Ser Gly Ser Lys Asn Asn Gln 
                325                 330                 335     


Val His Thr Leu Thr Pro Gly Glu Ser Leu Asp Ala Trp Thr Met Arg 
            340                 345                 350         


Gly Asn Leu Lys Gln Pro Asn Ser Lys Arg Glu Thr His Asn Ser Arg 
        355                 360                 365             


Ser Gly Ser Gly Ser Asp Pro Phe Asn Ile Asp His Ile Glu Val Ile 
    370                 375                 380                 


Ser Gly Ala Thr Gly Ser Gly Ser Gln Glu His Gly Lys Phe Gly Asn 
385                 390                 395                 400 


Ser Thr Thr Gly Ser Gly Ser Val Ala Gln Gln Asn Asp Asp Asn Glu 
                405                 410                 415     


Ile Ile Val Ser Ala Ser 
            420         


<210>  27
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding a MoLE Protein

<400>  27
caccaccacc accaccaccg tgaagttaaa agcggcaaaa aagataaata caaccactgg       60

gatctgaact atgaaagccg taaaccgggt agcggtagtg gtattagcat taccggtggt      120

aatgaaaaac cggatattag tattggtagc ggcagcaaaa ataaccaggt tcataccctg      180

acaccgggtg aaagcctgga tgcatggacc atgcgtggta atctgaaaca gccgaatagc      240

aaacgtgaaa cccataatag ccgtagcggt tcaggtagcg aaaaagttat tcgtgaagtg      300

aaatcgggta aaaaagacaa atatggcagc ggtagccaag aacatggtaa atttggtaat      360

agcaccacct aa                                                          372


<210>  28
<211>  461
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein

<400>  28

His His His His His His Phe Asp Arg Asp Tyr Thr Thr Val Trp Gly 
1               5                   10                  15      


Gln Arg Ala Pro Leu Tyr Tyr Ser Pro Gly Tyr Gly Pro Ala Ser Leu 
            20                  25                  30          


Tyr Asp Tyr Lys Gly Arg Gly Gly Ser Gly Ser Gly Ile Ser Ile Thr 
        35                  40                  45              


Gly Gly Asn Glu Lys Pro Asp Ile Ser Ile Gly Ser Gly Ser Ser Gln 
    50                  55                  60                  


Gly Asp Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly Phe Ser Ala Ile 
65                  70                  75                  80  


Ser Gly Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu Asn Ser Asp Arg 
                85                  90                  95      


Ile Pro Gly Thr Glu Arg Gly Ser Gly Ser Glu Lys Val Ile Arg Glu 
            100                 105                 110         


Val Lys Ser Gly Lys Lys Asp Lys Tyr Gly Ser Gly Ser Asp Glu Ser 
        115                 120                 125             


Leu Arg Phe Tyr Pro Phe Pro Thr Val Asn Ala Asn Lys Gln Ala Thr 
    130                 135                 140                 


Ala Phe Ser Ser Ser Gln Gln Asp Thr Asp Gln Gly Ser Gly Ser Phe 
145                 150                 155                 160 


Asp Arg Asp Tyr Thr Thr Val Trp Gly Gln Arg Ala Pro Leu Tyr Tyr 
                165                 170                 175     


Ser Pro Gly Tyr Gly Pro Ala Ser Leu Tyr Asp Tyr Lys Gly Arg Gly 
            180                 185                 190         


Gly Ser Gly Ser Gly Ile Ser Ile Thr Gly Gly Asn Glu Lys Pro Asp 
        195                 200                 205             


Ile Ser Ile Gly Ser Gly Ser Ser Gln Gly Asp Asp Asn Tyr Gly Leu 
    210                 215                 220                 


Asn Leu Gly Lys Gly Phe Ser Ala Ile Ser Gly Ser Ser Thr Pro Tyr 
225                 230                 235                 240 


Val Ser Lys Gly Leu Asn Ser Asp Arg Ile Pro Gly Thr Glu Arg Gly 
                245                 250                 255     


Ser Gly Ser Glu Lys Val Ile Arg Glu Val Lys Ser Gly Lys Lys Asp 
            260                 265                 270         


Lys Tyr Gly Ser Gly Ser Asp Glu Ser Leu Arg Phe Tyr Pro Phe Pro 
        275                 280                 285             


Thr Val Asn Ala Asn Lys Gln Ala Thr Ala Phe Ser Ser Ser Gln Gln 
    290                 295                 300                 


Asp Thr Asp Gln Gly Ser Gly Ser Phe Asp Arg Asp Tyr Thr Thr Val 
305                 310                 315                 320 


Trp Gly Gln Arg Ala Pro Leu Tyr Tyr Ser Pro Gly Tyr Gly Pro Ala 
                325                 330                 335     


Ser Leu Tyr Asp Tyr Lys Gly Arg Gly Gly Ser Gly Ser Gly Ile Ser 
            340                 345                 350         


Ile Thr Gly Gly Asn Glu Lys Pro Asp Ile Ser Ile Gly Ser Gly Ser 
        355                 360                 365             


Ser Gln Gly Asp Asp Asn Tyr Gly Leu Asn Leu Gly Lys Gly Phe Ser 
    370                 375                 380                 


Ala Ile Ser Gly Ser Ser Thr Pro Tyr Val Ser Lys Gly Leu Asn Ser 
385                 390                 395                 400 


Asp Arg Ile Pro Gly Thr Glu Arg Gly Ser Gly Ser Glu Lys Val Ile 
                405                 410                 415     


Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Gly Ser Gly Ser Asp 
            420                 425                 430         


Glu Ser Leu Arg Phe Tyr Pro Phe Pro Thr Val Asn Ala Asn Lys Gln 
        435                 440                 445             


Ala Thr Ala Phe Ser Ser Ser Gln Gln Asp Thr Asp Gln 
    450                 455                 460     


<210>  29
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding a MoLE Protein

<400>  29
caccaccacc accaccaccg tgaagttaaa agcggcaaaa aagataaata caaccactgg       60

gatctgaact atgaaagccg taaaccgggt agcggtagtg gtattagcat taccggtggt      120

aatgaaaaac cggatattag tattggtagc ggcagcaaaa ataaccaggt tcataccctg      180

acaccgggtg aaagcctgga tgcatggacc atgcgtggta atctgaaaca gccgaatagc      240

aaacgtgaaa cccataatag ccgtagcggt tcaggtagcg aaaaagttat tcgtgaagtg      300

aaatcgggta aaaaagacaa atatggcagc ggtagccaag aacatggtaa atttggtaat      360

agcaccacct aa                                                          372


<210>  30
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  MoLE Protein

<400>  30

His His His His His His Arg Glu Val Lys Ser Gly Lys Lys Asp Lys 
1               5                   10                  15      


Tyr Asn His Trp Asp Leu Asn Tyr Glu Ser Arg Lys Pro Gly Ser Gly 
            20                  25                  30          


Ser Gly Ile Ser Ile Thr Gly Gly Asn Glu Lys Pro Asp Ile Ser Ile 
        35                  40                  45              


Gly Ser Gly Ser Lys Asn Asn Gln Val His Thr Leu Thr Pro Gly Glu 
    50                  55                  60                  


Ser Leu Asp Ala Trp Thr Met Arg Gly Asn Leu Lys Gln Pro Asn Ser 
65                  70                  75                  80  


Lys Arg Glu Thr His Asn Ser Arg Ser Gly Ser Gly Ser Glu Lys Val 
                85                  90                  95      


Ile Arg Glu Val Lys Ser Gly Lys Lys Asp Lys Tyr Gly Ser Gly Ser 
            100                 105                 110         


Gln Glu His Gly Lys Phe Gly Asn Ser Thr Thr 
        115                 120             


