                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Purcell, Lisa A.
       Viau, Jonathan
       Olson, William
 
<120>  Human Antibodies to Influenza Hemagglutinin

<130>  10201WO01

<140>  TBD
<141>  2019-01-24

<150>  62/622,480
<151>  2018-01-26

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggttttagca tgaactgggt ccgccaggtt      120

ccagggaagg ggctggagtg ggtctcatcc attagtacta gtggtaatta catgtactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa gtcattctct      240

ctgcaaatga acagcctgag agccgaggac tcggctatat attactgtgc gagagggggg      300

gggtataact ggaacctctt tgactactgg ggccagggtt ccctggtcac cgtctcctca      360


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Phe 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Thr Ser Gly Asn Tyr Met Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Phe Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Asn Trp Asn Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
ggattcacct tcagtggttt tagc                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Gly Phe Thr Phe Ser Gly Phe Ser 
1               5               


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
attagtacta gtggtaatta catg                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Ile Ser Thr Ser Gly Asn Tyr Met 
1               5               


<210>  7
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
gcgagagggg gggggtataa ctggaacctc tttgactac                              39


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Ala Arg Gly Gly Gly Tyr Asn Trp Asn Leu Phe Asp Tyr 
1               5                   10              


<210>  9
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtcttaac agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccagact cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcac cagactggag      240

tctgaagatt ttgcagtata ttactgtcag caatatggta actccccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Asn Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
cagagtctta acagcaacta c                                                 21


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Gln Ser Leu Asn Ser Asn Tyr 
1               5           


<210>  13
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
ggtgcatcc                                                                9


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Gly Ala Ser 
1           


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
cagcaatatg gtaactcccc gctcact                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Gln Gln Tyr Gly Asn Ser Pro Leu Thr 
1               5                   


<210>  17
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagtttcagt ggttttagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtacta gtggtaatta catgtactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa gtcattctct      240

ctgcaaatga acagcctgag agccgaggac tcggctatat attactgtgc gagagggggg      300

gggtataact ggaacctctt tgactactgg ggccagggtt ccctggtcac cgtctcctca      360


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Phe 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Thr Ser Gly Asn Tyr Met Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Phe Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Asn Trp Asn Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
ggattcagtt tcagtggttt tagc                                              24


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Gly Phe Ser Phe Ser Gly Phe Ser 
1               5               


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
attagtacta gtggtaatta catg                                              24


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Ile Ser Thr Ser Gly Asn Tyr Met 
1               5               


<210>  23
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
gcgagagggg gggggtataa ctggaacctc tttgactac                              39


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Ala Arg Gly Gly Gly Tyr Asn Trp Asn Leu Phe Asp Tyr 
1               5                   10              


<210>  25
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtcttaac agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccagact cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctggggca gacttcactc tcaccatcag cagactggag      240

tctgaagatt ttgcagtgta ttactgtcag caatatggta actccccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Asn Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
cagagtctta acagcaacta c                                                 21


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Gln Ser Leu Asn Ser Asn Tyr 
1               5           


<210>  29
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
ggtgcatcc                                                                9


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Gly Ala Ser 
1           


<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
cagcaatatg gtaactcccc gctcact                                           27


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Gln Gln Tyr Gly Asn Ser Pro Leu Thr 
1               5                   


<210>  33
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A/Wisconsin/67/X-161/2005 (H3N2) Accession No: ACF41911.1 aa1-16:
       signal peptide aa17-566: Mature protein

<400>  33

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asp Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Gln Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Val Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  34
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A/chicken/Netherlands/01/2003 (H7N7) Accession No. AAR02640.1 
       aa1-18: signal peptide aa19-538: Mature protein

<400>  34

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Val Ala Ser Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Arg Thr Asn Val Pro Arg Ile Cys Ser Lys Gly Lys 
    50                  55                  60                  


Arg Thr Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly 
65                  70                  75                  80  


Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile 
                85                  90                  95      


Glu Arg Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn 
            100                 105                 110         


Glu Glu Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys 
        115                 120                 125             


Glu Thr Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Thr Thr 
    130                 135                 140                 


Ser Ala Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp 
145                 150                 155                 160 


Leu Leu Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser 
                165                 170                 175     


Tyr Lys Asn Thr Arg Lys Asp Pro Ala Leu Ile Ile Trp Gly Ile His 
            180                 185                 190         


His Ser Gly Ser Thr Thr Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn 
        195                 200                 205             


Lys Leu Ile Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro 
    210                 215                 220                 


Ser Pro Gly Ala Arg Pro Gln Val Asn Gly Gln Ser Gly Arg Ile Asp 
225                 230                 235                 240 


Phe His Trp Leu Ile Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe 
                245                 250                 255     


Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys 
            260                 265                 270         


Ser Met Gly Ile Gln Ser Glu Val Gln Val Asp Ala Asn Cys Glu Gly 
        275                 280                 285             


Asp Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln 
    290                 295                 300                 


Asn Ile Asn Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln 
305                 310                 315                 320 


Glu Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro 
                325                 330                 335     


Lys Arg Arg Arg Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu 
            340                 345                 350         


Asn Gly Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln 
        355                 360                 365             


Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser 
    370                 375                 380                 


Ala Ile Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr 
385                 390                 395                 400 


Asn Gln Gln Phe Glu Leu Ile Asp Asn Glu Phe Thr Glu Val Glu Arg 
                405                 410                 415     


Gln Ile Gly Asn Val Ile Asn Trp Thr Arg Asp Ser Met Thr Glu Val 
            420                 425                 430         


Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr 
        435                 440                 445             


Ile Asp Leu Ala Asp Ser Glu Met Asn Lys Leu Tyr Glu Arg Val Lys 
    450                 455                 460                 


Arg Gln Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu 
465                 470                 475                 480 


Ile Phe His Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn 
                485                 490                 495     


Thr Tyr Asp His Ser Lys Tyr Arg Glu Glu Ala Ile Gln Asn Arg Ile 
            500                 505                 510         


Gln Ile Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu 
        515                 520                 525             


Trp Phe Ser Phe Gly Ala Ser Cys Phe Ala His His His His His His 
    530                 535                 540                 


His His His His Tyr 
545                 


