                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
       Kugel, Sita
 
<120>  Treatment methods for pancreatic tumors associated with the worst
        prognosis

<130>  F053-0077PCT/18-028-WO-PCT

<150>  62/620,332
<151>  2018-01-22

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  2754
<212>  DNA
<213>  Homo sapiens

<400>  1
atgattgcct cgcatctgct tgcctacttc ttcacggagc tcaaccatga ccaagtgcag       60

aaggttgacc agtatctcta ccacatgcgc ctctctgatg agaccctctt ggagatctct      120

aagcggttcc gcaaggagat ggagaaaggg cttggagcca ccactcaccc tactgcagca      180

gtgaagatgc tgcccacctt tgtgaggtcc actccagatg ggacagaaca cggagagttc      240

ctggctctgg atcttggagg gaccaacttc cgtgtgcttt gggtgaaagt aacggacaat      300

gggctccaga aggtggagat ggagaatcag atctatgcca tccctgagga catcatgcga      360

ggcagtggca cccagctgtt tgaccacatt gccgaatgcc tggctaactt catggataag      420

ctacaaatca aagacaagaa gctcccactg ggttttacct tctcgttccc ctgccaccag      480

actaaactag acgagagttt cctggtctca tggaccaagg gattcaagtc cagtggagtg      540

gaaggcagag acgttgtggc tctgatccgg aaggccatcc agaggagagg ggactttgat      600

atcgacattg tggctgtggt gaatgacaca gttgggacca tgatgacctg tggttatgat      660

gaccacaact gtgagattgg tctcattgtg ggcacgggca gcaacgcctg ctacatggaa      720

gagatgcgcc acatcgacat ggtggaaggc gatgaggggc ggatgtgtat caatatggag      780

tggggggcct tcggggacga tggctcgctc aacgacattc gcactgagtt tgaccaggag      840

attgacatgg gctcactgaa cccgggaaag caactgtttg agaagatgat cagtgggatg      900

tacatggggg agctggtgag gcttatcctg gtgaagatgg ccaaggagga gctgctcttt      960

ggggggaagc tcagcccaga gcttctcaac accggtcgct ttgagaccaa agacatctca     1020

gacattgaag gggagaagga tggcatccgg aaggcccgtg aggtcctgat gcggttgggc     1080

ctggacccga ctcaggagga ctgcgtggcc actcaccgga tctgccagat cgtgtccaca     1140

cgctccgcca gcctgtgcgc agccaccctg gccgccgtgc tgcagcgcat caaggagaac     1200

aaaggcgagg agcggctgcg ctctactatt ggggtcgacg gttccgtcta caagaaacac     1260

ccccattttg ccaagcgtct acataagacc gtgcggcggc tggtgcccgg ctgcgatgtc     1320

cgcttcctcc gctccgagga tggcagtggc aaaggtgcag ccatggtgac agcagtggct     1380

taccggctgg ccgatcaaca ccgtgcccgc cagaagacat tagagcatct gcagctgagc     1440

catgaccagc tgctggaggt caagaggagg atgaaggtag aaatggagcg aggtctgagc     1500

aaggagactc atgccagtgc ccccgtcaag atgctgccca cctacgtgtg tgctaccccg     1560

gacggcacag agaaagggga cttcttggcc ttggaccttg gaggaacaaa tttccgggtc     1620

ctgctggtcc gtgttcggaa tgggaagtgg ggtggagtgg agatgcacaa caagatctac     1680

gccatcccgc aggaggtcat gcacggcacc ggggacgagc tctttgacca cattgtccag     1740

tgcatcgcgg acttcctcga gtacatgggc atgaagggcg tgtccctgcc tctgggtttt     1800

accttctcct tcccctgcca gcagaacagc ctggacgaga gcatcctcct caagtggaca     1860

aaaggcttca aggcatctgg ctgcgagggc gaggacgtgg tgaccctgct gaaggaagcg     1920

atccaccggc gagaggagtt tgacctggat gtggttgctg tggtgaacga cacagtcgga     1980

actatgatga cctgtggctt tgaagaccct cactgtgaag ttggcctcat tgttggcacg     2040

ggcagcaatg cctgctacat ggaggagatg cgcaacgtgg aactggtgga aggagaagag     2100

gggcggatgt gtgtgaacat ggaatggggg gccttcgggg acaatggatg cctagatgac     2160

ttccgcacag aatttgatgt ggctgtggat gagctttcac tcaaccccgg caagcagagg     2220

ttcgagaaaa tgatcagtgg aatgtacctg ggtgagattg tccgtaacat tctcatcgat     2280

ttcaccaagc gtggactact cttccgaggc cgcatctcag agcggctcaa gacaaggggc     2340

atctttgaaa ccaagttctt gtctcagatt gagagtgact gcctggccct gctgcaagtc     2400

cgagccatcc tgcaacactt agggcttgag agcacctgtg acgacagcat cattgttaag     2460

gaggtgtgca ctgtggtggc ccggcgggca gcccagctct gtggcgcagg catggccgct     2520

gtggtggaca ggatacgaga aaaccgtggg ctggacgctc tcaaagtgac agtgggtgtg     2580

gatgggaccc tctacaagct acatcctcac tttgccaaag tcatgcatga gacagtgaag     2640

gacctggctc cgaaatgtga tgtgtctttc ctgcagtcag aggatggcag cgggaagggg     2700

gcggcgctca tcactgctgt ggcctgccgc atccgtgagg ctggacagcg atag           2754


<210>  2
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His 
1               5                   10                  15      


Asp Gln Val Gln Lys Val Asp Gln Tyr Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Leu Glu Ile Ser Lys Arg Phe Arg Lys Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe 
65                  70                  75                  80  


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Trp Val Lys 
                85                  90                  95      


Val Thr Asp Asn Gly Leu Gln Lys Val Glu Met Glu Asn Gln Ile Tyr 
            100                 105                 110         


Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp 
        115                 120                 125             


His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
145                 150                 155                 160 


Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys 
                165                 170                 175     


Ser Ser Gly Val Glu Gly Arg Asp Val Val Ala Leu Ile Arg Lys Ala 
            180                 185                 190         


Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp His Asn Cys 
    210                 215                 220                 


Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Asn Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Gln Glu Ile Asp Met Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Glu Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Lys Leu Ser Pro Glu Leu Leu Asn Thr Gly Arg Phe Glu Thr 
                325                 330                 335     


Lys Asp Ile Ser Asp Ile Glu Gly Glu Lys Asp Gly Ile Arg Lys Ala 
            340                 345                 350         


Arg Glu Val Leu Met Arg Leu Gly Leu Asp Pro Thr Gln Glu Asp Cys 
        355                 360                 365             


Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser 
    370                 375                 380                 


Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Gln Arg Ile Lys Glu Asn 
385                 390                 395                 400 


Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val 
                405                 410                 415     


Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Thr Val Arg 
            420                 425                 430         


Arg Leu Val Pro Gly Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu His Leu Gln Leu Ser 
465                 470                 475                 480 


His Asp Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu 
                485                 490                 495     


Arg Gly Leu Ser Lys Glu Thr His Ala Ser Ala Pro Val Lys Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg 
    530                 535                 540                 


Val Arg Asn Gly Lys Trp Gly Gly Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Gln Glu Val Met His Gly Thr Gly Asp Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys 
            580                 585                 590         


Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Asn Ser Leu Asp Glu Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala 
625                 630                 635                 640 


Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Gly Phe Glu Asp Pro His Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Arg Asn Val Glu Leu Val Glu Gly Glu Glu Gly Arg Met Cys 
    690                 695                 700                 


Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Phe Arg Thr Glu Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro 
                725                 730                 735     


Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe 
        755                 760                 765             


Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Arg Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Ala Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Lys 
865                 870                 875                 880 


Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Gln Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg 
            900                 905                 910         


Glu Ala Gly Gln Arg 
        915         


<210>  3
<211>  1539
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaaagcca tcattcatct tactcttctt gctctccttt ctgtaaacac agccaccaac       60

caaggcaact cagctgatgc tgtaacaacc acagaaactg cgactagtgg tcctacagta      120

gctgcagctg ataccactga aactaatttc cctgaaactg ctagcaccac agcaaataca      180

ccttctttcc caacagctac ttcacctgct ccccccataa ttagtacaca tagttcctcc      240

acaattccta cacctgctcc ccccataatt agtacacata gttcctccac aattcctata      300

cctactgctg cagacagtga gtcaaccaca aatgtaaatt cattagctac ctctgacata      360

atcaccgctt catctccaaa tgatggatta atcacaatgg ttccttctga aacacaaagt      420

aacaatgaaa tgtcccccac cacagaagac aatcaatcat cagggcctcc cactggcacc      480

gctttattgg agaccagcac cctaaacagc acaggtccca gcaatccttg ccaagatgat      540

ccctgtgcag ataattcgtt atgtgttaag ctgcataata caagtttttg cctgtgttta      600

gaagggtatt actacaactc ttctacatgt aagaaaggaa aggtattccc tgggaagatt      660

tcagtgacag tatcagaaac atttgaccca gaagagaaac attccatggc ctatcaagac      720

ttgcatagtg aaattactag cttgtttaaa gatgtatttg gcacatctgt ttatggacag      780

actgtaattc ttactgtaag cacatctctg tcaccaagat ctgaaatgcg tgctgatgac      840

aagtttgtta atgtaacaat agtaacaatt ttggcagaaa ccacaagtga caatgagaag      900

actgtgactg agaaaattaa taaagcaatt agaagtagct caagcaactt tctaaactat      960

gatttgaccc ttcggtgtga ttattatggc tgtaaccaga ctgcggatga ctgcctcaat     1020

ggtttagcat gcgattgcaa atctgacctg caaaggccta acccacagag ccctttctgc     1080

gttgcttcca gtctcaagtg tcctgatgcc tgcaacgcac agcacaagca atgcttaata     1140

aagaagagtg gtggggcccc tgagtgtgcg tgcgtgcccg gctaccagga agatgctaat     1200

gggaactgcc aaaagtgtgc atttggctac agtggactcg actgtaagga caaatttcag     1260

ctgatcctca ctattgtggg caccatcgct ggcattgtca ttctcagcat gataattgca     1320

ttgattgtca cagcaagatc aaataacaaa acgaagcata ttgaagaaga gaacttgatt     1380

gacgaagact ttcaaaatct aaaactgcgg tcgacaggct tcaccaatct tggagcagaa     1440

gggagcgtct ttcctaaggt caggataacg gcctccagag acagccagat gcaaaatccc     1500

tattcaagac acagcagcat gccccgccct gactattag                            1539


<210>  4
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ala Ile Ile His Leu Thr Leu Leu Ala Leu Leu Ser Val Asn 
1               5                   10                  15      


Thr Ala Thr Asn Gln Gly Asn Ser Ala Asp Ala Val Thr Thr Thr Glu 
            20                  25                  30          


Thr Ala Thr Ser Gly Pro Thr Val Ala Ala Ala Asp Thr Thr Glu Thr 
        35                  40                  45              


Asn Phe Pro Glu Thr Ala Ser Thr Thr Ala Asn Thr Pro Ser Phe Pro 
    50                  55                  60                  


Thr Ala Thr Ser Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
65                  70                  75                  80  


Thr Ile Pro Thr Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
                85                  90                  95      


Thr Ile Pro Ile Pro Thr Ala Ala Asp Ser Glu Ser Thr Thr Asn Val 
            100                 105                 110         


Asn Ser Leu Ala Thr Ser Asp Ile Ile Thr Ala Ser Ser Pro Asn Asp 
        115                 120                 125             


Gly Leu Ile Thr Met Val Pro Ser Glu Thr Gln Ser Asn Asn Glu Met 
    130                 135                 140                 


Ser Pro Thr Thr Glu Asp Asn Gln Ser Ser Gly Pro Pro Thr Gly Thr 
145                 150                 155                 160 


Ala Leu Leu Glu Thr Ser Thr Leu Asn Ser Thr Gly Pro Ser Asn Pro 
                165                 170                 175     


Cys Gln Asp Asp Pro Cys Ala Asp Asn Ser Leu Cys Val Lys Leu His 
            180                 185                 190         


Asn Thr Ser Phe Cys Leu Cys Leu Glu Gly Tyr Tyr Tyr Asn Ser Ser 
        195                 200                 205             


Thr Cys Lys Lys Gly Lys Val Phe Pro Gly Lys Ile Ser Val Thr Val 
    210                 215                 220                 


Ser Glu Thr Phe Asp Pro Glu Glu Lys His Ser Met Ala Tyr Gln Asp 
225                 230                 235                 240 


Leu His Ser Glu Ile Thr Ser Leu Phe Lys Asp Val Phe Gly Thr Ser 
                245                 250                 255     


Val Tyr Gly Gln Thr Val Ile Leu Thr Val Ser Thr Ser Leu Ser Pro 
            260                 265                 270         


Arg Ser Glu Met Arg Ala Asp Asp Lys Phe Val Asn Val Thr Ile Val 
        275                 280                 285             


Thr Ile Leu Ala Glu Thr Thr Ser Asp Asn Glu Lys Thr Val Thr Glu 
    290                 295                 300                 


Lys Ile Asn Lys Ala Ile Arg Ser Ser Ser Ser Asn Phe Leu Asn Tyr 
305                 310                 315                 320 


Asp Leu Thr Leu Arg Cys Asp Tyr Tyr Gly Cys Asn Gln Thr Ala Asp 
                325                 330                 335     


Asp Cys Leu Asn Gly Leu Ala Cys Asp Cys Lys Ser Asp Leu Gln Arg 
            340                 345                 350         


Pro Asn Pro Gln Ser Pro Phe Cys Val Ala Ser Ser Leu Lys Cys Pro 
        355                 360                 365             


Asp Ala Cys Asn Ala Gln His Lys Gln Cys Leu Ile Lys Lys Ser Gly 
    370                 375                 380                 


Gly Ala Pro Glu Cys Ala Cys Val Pro Gly Tyr Gln Glu Asp Ala Asn 
385                 390                 395                 400 


Gly Asn Cys Gln Lys Cys Ala Phe Gly Tyr Ser Gly Leu Asp Cys Lys 
                405                 410                 415     


Asp Lys Phe Gln Leu Ile Leu Thr Ile Val Gly Thr Ile Ala Gly Ile 
            420                 425                 430         


Val Ile Leu Ser Met Ile Ile Ala Leu Ile Val Thr Ala Arg Ser Asn 
        435                 440                 445             


Asn Lys Thr Lys His Ile Glu Glu Glu Asn Leu Ile Asp Glu Asp Phe 
    450                 455                 460                 


Gln Asn Leu Lys Leu Arg Ser Thr Gly Phe Thr Asn Leu Gly Ala Glu 
465                 470                 475                 480 


Gly Ser Val Phe Pro Lys Val Arg Ile Thr Ala Ser Arg Asp Ser Gln 
                485                 490                 495     


Met Gln Asn Pro Tyr Ser Arg His Ser Ser Met Pro Arg Pro Asp Tyr 
            500                 505                 510         


<210>  5
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  5
atgctgccac tttggactct ttcactgctg ctgggagcag tagcaggaaa agaagtttgc       60

tacgaaagac tcggctgctt cagtgatgac tccccatggt caggaattac ggaaagaccc      120

ctccatatat tgccttggtc tccaaaagat gtcaacaccc gcttcctcct atatactaat      180

gagaacccaa acaactttca agaagttgcc gcagattcat caagcatcag tggctccaat      240

ttcaaaacaa atagaaaaac tcgctttatt attcatggat tcatagacaa gggagaagaa      300

aactggctgg ccaatgtgtg caagaatctg ttcaaggtgg aaagtgtgaa ctgtatctgt      360

gtggactgga aaggtggctc ccgaactgga tacacacaag cctcgcagaa catcaggatc      420

gtgggagcag aagtggcata ttttgttgaa tttcttcagt cggcgttcgg ttactcacct      480

tccaacgtgc atgtcattgg ccacagcctg ggtgcccacg ctgctgggga ggctggaagg      540

agaaccaatg ggaccattgg acgcatcaca gggttggacc cagcagaacc ttgctttcag      600

ggcacacctg aattagtccg attggacccc agcgatgcca aatttgtgga tgtaattcac      660

acggatggtg cccccatagt ccccaatttg gggtttggaa tgagccaagt cgtgggccac      720

ctagatttct ttccaaatgg aggagtggaa atgcctggat gtaaaaagaa cattctctct      780

cagattgtgg acatagacgg aatctgggaa gggactcgag actttgcggc ctgtaatcac      840

ttaagaagct acaaatatta cactgatagc atcgtcaacc ctgatggctt tgctggattc      900

ccctgtgcct cttacaacgt cttcactgca aacaagtgtt tcccttgtcc aagtggaggc      960

tgcccacaga tgggtcacta tgctgataga tatcctggga aaacaaatga tgtgggccag     1020

aaattttatc tagacactgg tgatgccagt aattttgcac gttggaggta taaggtatct     1080

gtcacactgt ctggaaaaaa ggttacagga cacatactag tttctttgtt cggaaataaa     1140

ggaaactcta agcagtatga aattttcaag ggcactctca aaccagatag tactcattcc     1200

aatgaatttg actcagatgt ggatgttggg gacttgcaga tggttaaatt tatttggtat     1260

aacaatgtga tcaacccaac tttacctaga gtgggagcat ccaagattat agtggagaca     1320

aatgttggaa aacagttcaa cttctgtagt ccagaaaccg tcagggagga agttctgctc     1380

accctcacac cgtgttag                                                   1398


<210>  6
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Pro Leu Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Ala Gly 
1               5                   10                  15      


Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro 
            20                  25                  30          


Trp Ser Gly Ile Thr Glu Arg Pro Leu His Ile Leu Pro Trp Ser Pro 
        35                  40                  45              


Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn 
    50                  55                  60                  


Asn Phe Gln Glu Val Ala Ala Asp Ser Ser Ser Ile Ser Gly Ser Asn 
65                  70                  75                  80  


Phe Lys Thr Asn Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp 
                85                  90                  95      


Lys Gly Glu Glu Asn Trp Leu Ala Asn Val Cys Lys Asn Leu Phe Lys 
            100                 105                 110         


Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
        115                 120                 125             


Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu 
    130                 135                 140                 


Val Ala Tyr Phe Val Glu Phe Leu Gln Ser Ala Phe Gly Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Val His Val Ile Gly His Ser Leu Gly Ala His Ala Ala Gly 
                165                 170                 175     


Glu Ala Gly Arg Arg Thr Asn Gly Thr Ile Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Glu Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu 
        195                 200                 205             


Asp Pro Ser Asp Ala Lys Phe Val Asp Val Ile His Thr Asp Gly Ala 
    210                 215                 220                 


Pro Ile Val Pro Asn Leu Gly Phe Gly Met Ser Gln Val Val Gly His 
225                 230                 235                 240 


Leu Asp Phe Phe Pro Asn Gly Gly Val Glu Met Pro Gly Cys Lys Lys 
                245                 250                 255     


Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
            260                 265                 270         


Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr 
        275                 280                 285             


Asp Ser Ile Val Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser 
    290                 295                 300                 


Tyr Asn Val Phe Thr Ala Asn Lys Cys Phe Pro Cys Pro Ser Gly Gly 
305                 310                 315                 320 


Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Asn 
                325                 330                 335     


Asp Val Gly Gln Lys Phe Tyr Leu Asp Thr Gly Asp Ala Ser Asn Phe 
            340                 345                 350         


Ala Arg Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys Lys Val 
        355                 360                 365             


Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Lys 
    370                 375                 380                 


Gln Tyr Glu Ile Phe Lys Gly Thr Leu Lys Pro Asp Ser Thr His Ser 
385                 390                 395                 400 


Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Met Val Lys 
                405                 410                 415     


Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Arg Val Gly 
            420                 425                 430         


Ala Ser Lys Ile Ile Val Glu Thr Asn Val Gly Lys Gln Phe Asn Phe 
        435                 440                 445             


Cys Ser Pro Glu Thr Val Arg Glu Glu Val Leu Leu Thr Leu Thr Pro 
    450                 455                 460                 


Cys 
465 


<210>  7
<211>  1761
<212>  DNA
<213>  Homo sapiens

<400>  7
atgttgtacc tggaaaacaa tgcccagact caatttagtg agccacagta cacgaacctg       60

gggctcctga acagcatgga ccagcagatt cagaacggct cctcgtccac cagtccctat      120

aacacagacc acgcgcagaa cagcgtcacg gcgccctcgc cctacgcaca gcccagctcc      180

accttcgatg ctctctctcc atcacccgcc atcccctcca acaccgacta cccaggcccg      240

cacagtttcg acgtgtcctt ccagcagtcg agcaccgcca agtcggccac ctggacgtat      300

tccactgaac tgaagaaact ctactgccaa attgcaaaga catgccccat ccagatcaag      360

gtgatgaccc cacctcctca gggagctgtt atccgcgcca tgcctgtcta caaaaaagct      420

gagcacgtca cggaggtggt gaagcggtgc cccaaccatg agctgagccg tgaattcaac      480

gagggacaga ttgcccctcc tagtcatttg attcgagtag aggggaacag ccatgcccag      540

tatgtagaag atcccatcac aggaagacag agtgtgctgg taccttatga gccaccccag      600

gttggcactg aattcacgac agtcttgtac aatttcatgt gtaacagcag ttgtgttgga      660

gggatgaacc gccgtccaat tttaatcatt gttactctgg aaaccagaga tgggcaagtc      720

ctgggccgac gctgctttga ggcccggatc tgtgcttgcc caggaagaga caggaaggcg      780

gatgaagata gcatcagaaa gcagcaagtt tcggacagta caaagaacgg tgatggtacg      840

aagcgcccgt ttcgtcagaa cacacatggt atccagatga catccatcaa gaaacgaaga      900

tccccagatg atgaactgtt atacttacca gtgaggggcc gtgagactta tgaaatgctg      960

ttgaagatca aagagtccct ggaactcatg cagtaccttc ctcagcacac aattgaaacg     1020

tacaggcaac agcaacagca gcagcaccag cacttacttc agaaacagac ctcaatacag     1080

tctccatctt catatggtaa cagctcccca cctctgaaca aaatgaacag catgaacaag     1140

ctgccttctg tgagccagct tatcaaccct cagcagcgca acgccctcac tcctacaacc     1200

attcctgatg gcatgggagc caacattccc atgatgggca cccacatgcc aatggctgga     1260

gacatgaatg gactcagccc cacccaggca ctccctcccc cactctccat gccatccacc     1320

tcccactgca cacccccacc tccgtatccc acagattgca gcattgtcag tttcttagcg     1380

aggttgggct gttcatcatg tctggactat ttcacgaccc aggggctgac caccatctat     1440

cagattgagc attactccat ggatgatctg gcaagtctga aaatccctga gcaatttcga     1500

catgcgatct ggaagggcat cctggaccac cggcagctcc acgaattctc ctccccttct     1560

catctcctgc ggaccccaag cagtgcctct acagtcagtg tgggctccag tgagacccgg     1620

ggtgagcgtg ttattgatgc tgtgcgattc accctccgcc agaccatctc tttcccaccc     1680

cgagatgagt ggaatgactt caactttgac atggatgctc gccgcaataa gcaacagcgc     1740

atcaaagagg agggggagtg a                                               1761


<210>  8
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Pro Gln 
1               5                   10                  15      


Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn 
            20                  25                  30          


Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser 
        35                  40                  45              


Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala 
    50                  55                  60                  


Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro 
65                  70                  75                  80  


His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala 
                85                  90                  95      


Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala 
            100                 105                 110         


Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly 
        115                 120                 125             


Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr 
    130                 135                 140                 


Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn 
                165                 170                 175     


Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val 
            180                 185                 190         


Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val 
        195                 200                 205             


Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg 
    210                 215                 220                 


Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val 
225                 230                 235                 240 


Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg 
                245                 250                 255     


Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp 
            260                 265                 270         


Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr 
        275                 280                 285             


His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp 
    290                 295                 300                 


Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu 
305                 310                 315                 320 


Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His 
                325                 330                 335     


Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu 
            340                 345                 350         


Leu Gln Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser 
        355                 360                 365             


Ser Pro Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val 
    370                 375                 380                 


Ser Gln Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr 
385                 390                 395                 400 


Ile Pro Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met 
                405                 410                 415     


Pro Met Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro 
            420                 425                 430         


Pro Pro Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro 
        435                 440                 445             


Tyr Pro Thr Asp Cys Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys 
    450                 455                 460                 


Ser Ser Cys Leu Asp Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr 
465                 470                 475                 480 


Gln Ile Glu His Tyr Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro 
                485                 490                 495     


Glu Gln Phe Arg His Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln 
            500                 505                 510         


Leu His Glu Phe Ser Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser 
        515                 520                 525             


Ala Ser Thr Val Ser Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val 
    530                 535                 540                 


Ile Asp Ala Val Arg Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro 
545                 550                 555                 560 


Arg Asp Glu Trp Asn Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn 
                565                 570                 575     


Lys Gln Gln Arg Ile Lys Glu Glu Gly Glu 
            580                 585     


<210>  9
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  9
atgttgtacc tggaaaacaa tgcccagact caatttagtg agccacagta cacgaacctg       60

gggctcctga acagcatgga ccagcagatt cagaacggct cctcgtccac cagtccctat      120

aacacagacc acgcgcagaa cagcgtcacg gcgccctcgc cctacgcaca gcccagctcc      180

accttcgatg ctctctctcc atcacccgcc atcccctcca acaccgacta cccaggcccg      240

cacagtttcg acgtgtcctt ccagcagtcg agcaccgcca agtcggccac ctggacgtat      300

tccactgaac tgaagaaact ctactgccaa attgcaaaga catgccccat ccagatcaag      360

gtgatgaccc cacctcctca gggagctgtt atccgcgcca tgcctgtcta caaaaaagct      420

gagcacgtca cggaggtggt gaagcggtgc cccaaccatg agctgagccg tgaattcaac      480

gagggacaga ttgcccctcc tagtcatttg attcgagtag aggggaacag ccatgcccag      540

tatgtagaag atcccatcac aggaagacag agtgtgctgg taccttatga gccaccccag      600

gttggcactg aattcacgac agtcttgtac aatttcatgt gtaacagcag ttgtgttgga      660

gggatgaacc gccgtccaat tttaatcatt gttactctgg aaaccagaga tgggcaagtc      720

ctgggccgac gctgctttga ggcccggatc tgtgcttgcc caggaagaga caggaaggcg      780

gatgaagata gcatcagaaa gcagcaagtt tcggacagta caaagaacgg tgatggtacg      840

aagcgcccgt ttcgtcagaa cacacatggt atccagatga catccatcaa gaaacgaaga      900

tccccagatg atgaactgtt atacttacca gtgaggggcc gtgagactta tgaaatgctg      960

ttgaagatca aagagtccct ggaactcatg cagtaccttc ctcagcacac aattgaaacg     1020

tacaggcaac agcaacagca gcagcaccag cacttacttc agaaacagac ctcaatacag     1080

tctccatctt catatggtaa cagctcccca cctctgaaca aaatgaacag catgaacaag     1140

ctgccttctg tgagccagct tatcaaccct cagcagcgca acgccctcac tcctacaacc     1200

attcctgatg gcatgggagc caacattccc atgatgggca cccacatgcc aatggctgga     1260

gacatgaatg gactcagccc cacccaggca ctccctcccc cactctccat gccatccacc     1320

tcccactgca cacccccacc tccgtatccc acagattgca gcattgtcag gatctggcaa     1380

gtctga                                                                1386


<210>  10
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Pro Gln 
1               5                   10                  15      


Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn 
            20                  25                  30          


Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser 
        35                  40                  45              


Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala 
    50                  55                  60                  


Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro 
65                  70                  75                  80  


His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala 
                85                  90                  95      


Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala 
            100                 105                 110         


Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly 
        115                 120                 125             


Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr 
    130                 135                 140                 


Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn 
                165                 170                 175     


Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val 
            180                 185                 190         


Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val 
        195                 200                 205             


Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg 
    210                 215                 220                 


Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val 
225                 230                 235                 240 


Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg 
                245                 250                 255     


Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp 
            260                 265                 270         


Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr 
        275                 280                 285             


His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp 
    290                 295                 300                 


Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu 
305                 310                 315                 320 


Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His 
                325                 330                 335     


Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu 
            340                 345                 350         


Leu Gln Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser 
        355                 360                 365             


Ser Pro Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val 
    370                 375                 380                 


Ser Gln Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr 
385                 390                 395                 400 


Ile Pro Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met 
                405                 410                 415     


Pro Met Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro 
            420                 425                 430         


Pro Pro Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro 
        435                 440                 445             


Tyr Pro Thr Asp Cys Ser Ile Val Arg Ile Trp Gln Val 
    450                 455                 460     


<210>  11
<211>  1182
<212>  DNA
<213>  Homo sapiens

<400>  11
atgttgtacc tggaaaacaa tgcccagact caatttagtg agccacagta cacgaacctg       60

gggctcctga acagcatgga ccagcagatt cagaacggct cctcgtccac cagtccctat      120

aacacagacc acgcgcagaa cagcgtcacg gcgccctcgc cctacgcaca gcccagctcc      180

accttcgatg ctctctctcc atcacccgcc atcccctcca acaccgacta cccaggcccg      240

cacagtttcg acgtgtcctt ccagcagtcg agcaccgcca agtcggccac ctggacgtat      300

tccactgaac tgaagaaact ctactgccaa attgcaaaga catgccccat ccagatcaag      360

gtgatgaccc cacctcctca gggagctgtt atccgcgcca tgcctgtcta caaaaaagct      420

gagcacgtca cggaggtggt gaagcggtgc cccaaccatg agctgagccg tgaattcaac      480

gagggacaga ttgcccctcc tagtcatttg attcgagtag aggggaacag ccatgcccag      540

tatgtagaag atcccatcac aggaagacag agtgtgctgg taccttatga gccaccccag      600

gttggcactg aattcacgac agtcttgtac aatttcatgt gtaacagcag ttgtgttgga      660

gggatgaacc gccgtccaat tttaatcatt gttactctgg aaaccagaga tgggcaagtc      720

ctgggccgac gctgctttga ggcccggatc tgtgcttgcc caggaagaga caggaaggcg      780

gatgaagata gcatcagaaa gcagcaagtt tcggacagta caaagaacgg tgatggtacg      840

aagcgcccgt ttcgtcagaa cacacatggt atccagatga catccatcaa gaaacgaaga      900

tccccagatg atgaactgtt atacttacca gtgaggggcc gtgagactta tgaaatgctg      960

ttgaagatca aagagtccct ggaactcatg cagtaccttc ctcagcacac aattgaaacg     1020

tacaggcaac agcaacagca gcagcaccag cacttacttc agaaacatct cctttcagcc     1080

tgcttcagga atgagcttgt ggagccccgg agagaaactc caaaacaatc tgacgtcttc     1140

tttagacatt ccaagccccc aaaccgatca gtgtacccat ag                        1182


<210>  12
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Pro Gln 
1               5                   10                  15      


Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn 
            20                  25                  30          


Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser 
        35                  40                  45              


Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala 
    50                  55                  60                  


Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro 
65                  70                  75                  80  


His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala 
                85                  90                  95      


Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala 
            100                 105                 110         


Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly 
        115                 120                 125             


Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr 
    130                 135                 140                 


Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn 
                165                 170                 175     


Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val 
            180                 185                 190         


Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val 
        195                 200                 205             


Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg 
    210                 215                 220                 


Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val 
225                 230                 235                 240 


Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg 
                245                 250                 255     


Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp 
            260                 265                 270         


Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr 
        275                 280                 285             


His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp 
    290                 295                 300                 


Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu 
305                 310                 315                 320 


Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His 
                325                 330                 335     


Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu 
            340                 345                 350         


Leu Gln Lys His Leu Leu Ser Ala Cys Phe Arg Asn Glu Leu Val Glu 
        355                 360                 365             


Pro Arg Arg Glu Thr Pro Lys Gln Ser Asp Val Phe Phe Arg His Ser 
    370                 375                 380                 


Lys Pro Pro Asn Arg Ser Val Tyr Pro 
385                 390             


<210>  13
<211>  1251
<212>  DNA
<213>  Homo sapiens

<400>  13
atgttgtacc tggaaaacaa tgcccagact caatttagtg agccacagta cacgaacctg       60

gggctcctga acagcatgga ccagcagatt cagaacggct cctcgtccac cagtccctat      120

aacacagacc acgcgcagaa cagcgtcacg gcgccctcgc cctacgcaca gcccagctcc      180

accttcgatg ctctctctcc atcacccgcc atcccctcca acaccgacta cccaggcccg      240

cacagtttcg acgtgtcctt ccagcagtcg agcaccgcca agtcggccac ctggacgtat      300

tccactgaac tgaagaaact ctactgccaa attgcaaaga catgccccat ccagatcaag      360

gtgatgaccc cacctcctca gggagctgtt atccgcgcca tgcctgtcta caaaaaagct      420

gagcacgtca cggaggtggt gaagcggtgc cccaaccatg agctgagccg tgaattcaac      480

gagggacaga ttgcccctcc tagtcatttg attcgagtag aggggaacag ccatgcccag      540

tatgtagaag atcccatcac aggaagacag agtgtgctgg taccttatga gccaccccag      600

gttggcactg aattcacgac agtcttgtac aatttcatgt gtaacagcag ttgtgttgga      660

gggatgaacc gccgtccaat tttaatcatt gttactctgg aaaccagaga tgggcaagtc      720

ctgggccgac gctgctttga ggcccggatc tgtgcttgcc caggaagaga caggaaggcg      780

gatgaagata gcatcagaaa gcagcaagtt tcggacagta caaagaacgg tgatggtacg      840

aagcgcccgt ttcgtcagaa cacacatggt atccagatga catccatcaa gaaacgaaga      900

tccccagatg atgaactgtt atacttacca gtgaggggcc gtgagactta tgaaatgctg      960

ttgaagatca aagagtccct ggaactcatg cagtaccttc ctcagcacac aattgaaacg     1020

tacaggcaac agcaacagca gcagcaccag cacttacttc agaaacagac ctcaatacag     1080

tctccatctt catatggtaa cagctcccca cctctgaaca aaatgaacag catgaacaag     1140

ctgccttctg tgagccagct tatcaaccct cagcagcgca acgccctcac tcctacaacc     1200

attcctgatg gcatgggagc caacagatct ggcaagtctg aaaatccctg a              1251


<210>  14
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Pro Gln 
1               5                   10                  15      


Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn 
            20                  25                  30          


Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser 
        35                  40                  45              


Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala 
    50                  55                  60                  


Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro 
65                  70                  75                  80  


His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala 
                85                  90                  95      


Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala 
            100                 105                 110         


Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly 
        115                 120                 125             


Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr 
    130                 135                 140                 


Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn 
                165                 170                 175     


Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val 
            180                 185                 190         


Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val 
        195                 200                 205             


Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg 
    210                 215                 220                 


Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val 
225                 230                 235                 240 


Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg 
                245                 250                 255     


Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp 
            260                 265                 270         


Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr 
        275                 280                 285             


His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp 
    290                 295                 300                 


Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu 
305                 310                 315                 320 


Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His 
                325                 330                 335     


Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu 
            340                 345                 350         


Leu Gln Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser 
        355                 360                 365             


Ser Pro Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val 
    370                 375                 380                 


Ser Gln Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr 
385                 390                 395                 400 


Ile Pro Asp Gly Met Gly Ala Asn Arg Ser Gly Lys Ser Glu Asn Pro 
                405                 410                 415     


<210>  15
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  15
atgttgtacc tggaaaacaa tgcccagact caatttagtg agtattccac tgaactgaag       60

aaactctact gccaaattgc aaagacatgc cccatccaga tcaaggtgat gaccccacct      120

cctcagggag ctgttatccg cgccatgcct gtctacaaaa aagctgagca cgtcacggag      180

gtggtgaagc ggtgccccaa ccatgagctg agccgtgaat tcaacgaggg acagattgcc      240

cctcctagtc atttgattcg agtagagggg aacagccatg cccagtatgt agaagatccc      300

atcacaggaa gacagagtgt gctggtacct tatgagccac cccaggttgg cactgaattc      360

acgacagtct tgtacaattt catgtgtaac agcagttgtg ttggagggat gaaccgccgt      420

ccaattttaa tcattgttac tctggaaacc agagatgggc aagtcctggg ccgacgctgc      480

tttgaggccc ggatctgtgc ttgcccagga agagacagga aggcggatga agatagcatc      540

agaaagcagc aagtttcgga cagtacaaag aacggtgatg gtacgaagcg cccgtttcgt      600

cagaacacac atggtatcca gatgacatcc atcaagaaac gaagatcccc agatgatgaa      660

ctgttatact taccagtgag gggccgtgag acttatgaaa tgctgttgaa gatcaaagag      720

tccctggaac tcatgcagta ccttcctcag cacacaattg aaacgtacag gcaacagcaa      780

cagcagcagc accagcactt acttcagaaa cagacctcaa tacagtctcc atcttcatat      840

ggtaacagct ccccacctct gaacaaaatg aacagcatga acaagctgcc ttctgtgagc      900

cagcttatca accctcagca gcgcaacgcc ctcactccta caaccattcc tgatggcatg      960

ggagccaaca ttcccatgat gggcacccac atgccaatgg ctggagacat gaatggactc     1020

agccccaccc aggcactccc tcccccactc tccatgccat ccacctccca ctgcacaccc     1080

ccacctccgt atcccacaga ttgcagcatt gtcagtttct tagcgaggtt gggctgttca     1140

tcatgtctgg actatttcac gacccagggg ctgaccacca tctatcagat tgagcattac     1200

tccatggatg atctggcaag tctgaaaatc cctgagcaat ttcgacatgc gatctggaag     1260

ggcatcctgg accaccggca gctccacgaa ttctcctccc cttctcatct cctgcggacc     1320

ccaagcagtg cctctacagt cagtgtgggc tccagtgaga cccggggtga gcgtgttatt     1380

gatgctgtgc gattcaccct ccgccagacc atctctttcc caccccgaga tgagtggaat     1440

gacttcaact ttgacatgga tgctcgccgc aataagcaac agcgcatcaa agaggagggg     1500

gagtga                                                                1506


<210>  16
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Tyr Ser 
1               5                   10                  15      


Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro Ile 
            20                  25                  30          


Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly Ala Val Ile Arg Ala 
        35                  40                  45              


Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Glu Val Val Lys Arg 
    50                  55                  60                  


Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn Glu Gly Gln Ile Ala 
65                  70                  75                  80  


Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn Ser His Ala Gln Tyr 
                85                  90                  95      


Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val Leu Val Pro Tyr Glu 
            100                 105                 110         


Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val Leu Tyr Asn Phe Met 
        115                 120                 125             


Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu Ile 
    130                 135                 140                 


Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val Leu Gly Arg Arg Cys 
145                 150                 155                 160 


Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala Asp 
                165                 170                 175     


Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp Ser Thr Lys Asn Gly 
            180                 185                 190         


Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr His Gly Ile Gln Met 
        195                 200                 205             


Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu 
    210                 215                 220                 


Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu 
225                 230                 235                 240 


Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr 
                245                 250                 255     


Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln Thr 
            260                 265                 270         


Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser Ser Pro Pro Leu Asn 
        275                 280                 285             


Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val Ser Gln Leu Ile Asn 
    290                 295                 300                 


Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr Ile Pro Asp Gly Met 
305                 310                 315                 320 


Gly Ala Asn Ile Pro Met Met Gly Thr His Met Pro Met Ala Gly Asp 
                325                 330                 335     


Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro Pro Pro Leu Ser Met 
            340                 345                 350         


Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro Tyr Pro Thr Asp Cys 
        355                 360                 365             


Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys Ser Ser Cys Leu Asp 
    370                 375                 380                 


Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr Gln Ile Glu His Tyr 
385                 390                 395                 400 


Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro Glu Gln Phe Arg His 
                405                 410                 415     


Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln Leu His Glu Phe Ser 
            420                 425                 430         


Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser Ala Ser Thr Val Ser 
        435                 440                 445             


Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val Ile Asp Ala Val Arg 
    450                 455                 460                 


Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro Arg Asp Glu Trp Asn 
465                 470                 475                 480 


Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn Lys Gln Gln Arg Ile 
                485                 490                 495     


Lys Glu Glu Gly Glu 
            500     


<210>  17
<211>  852
<212>  DNA
<213>  Homo sapiens

<400>  17
atgaacggcg aggagcagta ctacgcggcc acgcagcttt acaaggaccc atgcgcgttc       60

cagcgaggcc cggcgccgga gttcagcgcc agcccccctg cgtgcctgta catgggccgc      120

cagcccccgc cgccgccgcc gcacccgttc cctggcgccc tgggcgcgct ggagcagggc      180

agccccccgg acatctcccc gtacgaggtg ccccccctcg ccgacgaccc cgcggtggcg      240

caccttcacc accacctccc ggctcagctc gcgctccccc acccgcccgc cgggcccttc      300

ccggagggag ccgagccggg cgtcctggag gagcccaacc gcgtccagct gcctttccca      360

tggatgaagt ctaccaaagc tcacgcgtgg aaaggccagt gggcaggcgg cgcctacgct      420

gcggagccgg aggagaacaa gcggacgcgc acggcctaca cgcgcgcaca gctgctagag      480

ctggagaagg agttcctatt caacaagtac atctcacggc cgcgccgggt ggagctggct      540

gtcatgttga acttgaccga gagacacatc aagatctggt tccaaaaccg ccgcatgaag      600

tggaaaaagg aggaggacaa gaagcgcggc ggcgggacag ctgtcggggg tggcggggtc      660

gcggagcctg agcaggactg cgccgtgacc tccggcgagg agcttctggc gctgccgccg      720

ccgccgcccc ccggaggtgc tgtgccgccc gctgcccccg ttgccgcccg agagggccgc      780

ctgccgcctg gccttagcgc gtcgccacag ccctccagcg tcgcgcctcg gcggccgcag      840

gaaccacgat ga                                                          852


<210>  18
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro Pro Ala Ala Pro Val Ala Ala 
                245                 250                 255     


Arg Glu Gly Arg Leu Pro Pro Gly Leu Ser Ala Ser Pro Gln Pro Ser 
            260                 265                 270         


Ser Val Ala Pro Arg Arg Pro Gln Glu Pro Arg 
        275                 280             


<210>  19
<211>  1788
<212>  DNA
<213>  Homo sapiens

<400>  19
atggccttga ctgacggcgg ctggtgcttg ccgaagcgct tcggggccgc gggtgcggac       60

gccagcgact ccagagcctt tccagcgcgg gagccctcca cgccgccttc ccccatctct      120

tcctcgtcct cctcctgctc ccggggcgga gagcggggcc ccggcggcgc cagcaactgc      180

gggacgcctc agctcgacac ggaggcggcg gccggacccc cggcccgctc gctgctgctc      240

agttcctacg cttcgcatcc cttcggggct ccccacggac cttcggcgcc tggggtcgcg      300

ggccccgggg gcaacctgtc gagctgggag gacttgctgc tgttcactga cctcgaccaa      360

gccgcgaccg ccagcaagct gctgtggtcc agccgcggcg ccaagctgag ccccttcgca      420

cccgagcagc cggaggagat gtaccagacc ctcgccgctc tctccagcca gggtccggcc      480

gcctacgacg gcgcgcccgg cggcttcgtg cactctgcgg ccgcggcggc agcagccgcg      540

gcggcggcca gctccccggt ctacgtgccc accacccgcg tgggttccat gctgcccggc      600

ctaccgtacc acctgcaggg gtcgggcagt gggccagcca accacgcggg cggcgcgggc      660

gcgcaccccg gctggcctca ggcctcggcc gacagccctc catacggcag cggaggcggc      720

gcggctggcg gcggggccgc ggggcctggc ggcgctggct cagccgcggc gcacgtctcg      780

gcgcgcttcc cctactctcc cagcccgccc atggccaacg gcgccgcgcg ggagccggga      840

ggctacgcgg cggcgggcag tgggggcgcg ggaggcgtga gcggcggcgg cagtagcctg      900

gcggccatgg gcggccgcga gccccagtac agctcgctgt cggccgcgcg gccgctgaac      960

gggacgtacc accaccacca ccaccaccac caccaccatc cgagccccta ctcgccctac     1020

gtgggggcgc cactgacgcc tgcctggccc gccggaccct tcgagacccc ggtgctgcac     1080

agcctgcaga gccgcgccgg agccccgctc ccggtgcccc ggggtcccag tgcagacctg     1140

ctggaggacc tgtccgagag ccgcgagtgc gtgaactgcg gctccatcca gacgccgctg     1200

tggcggcggg acggcaccgg ccactacctg tgcaacgcct gcgggctcta cagcaagatg     1260

aacggcctca gccggcccct catcaagccg cagaagcgcg tgccttcatc acggcggctt     1320

ggattgtcct gtgccaactg tcacaccaca actaccacct tatggcgcag aaacgccgag     1380

ggtgaacccg tgtgcaatgc ttgtggactc tacatgaaac tccatggggt gcccagacca     1440

cttgctatga aaaaagaggg aattcaaacc aggaaacgaa aacctaagaa cataaataaa     1500

tcaaagactt gctctggtaa tagcaataat tccattccca tgactccaac ttccacctct     1560

tctaactcag atgattgcag caaaaatact tcccccacaa cacaacctac agcctcaggg     1620

gcgggtgccc cggtgatgac tggtgcggga gagagcacca atcccgagaa cagcgagctc     1680

aagtattcgg gtcaagatgg gctctacata ggcgtcagtc tcgcctcgcc ggccgaagtc     1740

acgtcctccg tgcgaccgga ttcctggtgc gccctggccc tggcctga                  1788


<210>  20
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      


Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala Arg Glu Pro 
            20                  25                  30          


Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              


Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly Thr Pro Gln 
    50                  55                  60                  


Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser Leu Leu Leu 
65                  70                  75                  80  


Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly Pro Ser Ala 
                85                  90                  95      


Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp Glu Asp Leu 
            100                 105                 110         


Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             


Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro Glu Gln Pro 
    130                 135                 140                 


Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 


Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         


Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser 
        195                 200                 205             


Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly 
    210                 215                 220                 


Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala 
                245                 250                 255     


Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala 
            260                 265                 270         


Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly 
        275                 280                 285             


Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly 
    290                 295                 300                 


Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn 
305                 310                 315                 320 


Gly Thr Tyr His His His His His His His His His His Pro Ser Pro 
                325                 330                 335     


Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly 
            340                 345                 350         


Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala 
        355                 360                 365             


Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu 
    370                 375                 380                 


Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu 
385                 390                 395                 400 


Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                405                 410                 415     


Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys 
            420                 425                 430         


Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His 
        435                 440                 445             


Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    450                 455                 460                 


Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
465                 470                 475                 480 


Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                485                 490                 495     


Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile 
            500                 505                 510         


Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys 
        515                 520                 525             


Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro 
    530                 535                 540                 


Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu 
545                 550                 555                 560 


Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser 
                565                 570                 575     


Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu 
            580                 585                 590         


Ala Leu Ala 
        595 


<210>  21
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  21
atggctctgg acgtgaagtc tcgggcaaag cgttatgaga agctggactt ccttggggag       60

ggacagtttg ccaccgttta caaggccaga gataagaaca ccaaccaaat tgtcgccatt      120

aagaaaatca aacttggaca tagatcagaa gctaaagatg gtataaatag aaccgcctta      180

agagagataa aattattaca ggagctaagt catccaaata taattggtct ccttgatgct      240

tttggacata aatctaatat tagccttgtc tttgatttta tggaaactga tctagaggtt      300

ataataaagg ataatagtct tgtgctgaca ccatcacaca tcaaagccta catgttgatg      360

actcttcaag gattagaata tttacatcaa cattggatcc tacataggga tctgaaacca      420

aacaacttgt tgctagatga aaatggagtt ctaaaactgg cagattttgg cctggccaaa      480

tcttttggga gccccaatag agcttataca catcaggttg taaccaggtg gtatcgggcc      540

cccgagttac tatttggagc taggatgtat ggtgtaggtg tggacatgtg ggctgttggc      600

tgtatattag cagagttact tctaagggtt ccttttttgc caggagattc agaccttgat      660

cagctaacaa gaatatttga aactttgggc acaccaactg aggaacagtg gccggacatg      720

tgtagtcttc cagattatgt gacatttaag agtttccctg gaataccttt gcatcacatc      780

ttcagtgcag caggagacga cttactagat ctcatacaag gcttattctt atttaatcca      840

tgtgctcgaa ttacggccac acaggcactg aaaatgaagt atttcagtaa tcggccaggg      900

ccaacacctg gatgtcagct gccaagacca aactgtccag tggaaacctt aaaggagcaa      960

tcaaatccag ctttggcaat aaaaaggaaa agaacagagg ccttagaaca aggaggattg     1020

cccaagaaac taatttttta a                                               1041


<210>  22
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


