                         SEQUENCE LISTING

<110>  Vertex Pharmaceuticals Incorporated
       MAHAJAN, Sudipta
       WEINBERG, Marc Saul
       D'ASTOLFO, Diego Sebastian
 
<120>  DNA-PK INHIBITORS

<130>  14390-686

<150>  US 62/618,598
<151>  2018-01-17

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 target site

<400>  1
accccacagt ggggccacta                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NAV1.7 target

<400>  2
ggctgagcgt ccatcaacca                                                   20


<210>  3
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 sgRNA


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl 3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl 3'-phosphorothioate

<400>  3
accccacagu ggggccacua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  4
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NAV1.7 sgRNA


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl 3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl 3'-phosphorothioate

<400>  4
ggcugagcgu ccaucaacca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  5
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 PAM


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl 3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (87)..(89)
<223>  2'-O-methyl 3'-phosphorothioate

<400>  5
gggtactttt atctgtcccc tccaccccac agtggggcca gaattctcag ctagggacag       60

gattggtgac agaaaagccc catccttagg                                        90


<210>  6
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 Non-PAM


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl 3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (87)..(89)
<223>  2'-O-methyl 3'-phosphorothioate

<400>  6
cctaaggatg gggcttttct gtcaccaatc ctgtccctag ctgagaattc tggccccact       60

gtggggtgga ggggacagat aaaagtaccc                                        90


<210>  7
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NAV1.7 PAM


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl 3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (87)..(89)
<223>  2'-O-methyl 3'-phosphorothioate

<400>  7
agctgtccat tggggagcat gagggctgag cgtccatcaa ctgagaattc ccagggagac       60

cacaccgttg cagtccacag cactgtgcat                                        90


<210>  8
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NAV1.7 Non-PAM


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl 3'-phosphorothioate

<220>
<221>  misc_feature
<222>  (87)..(89)
<223>  2'-O-methyl 3'-phosphorothioate

<400>  8
atgcacagtg ctgtggactg caacggtgtg gtctccctgg gaattctcag ttgatggacg       60

ctcagccctc atgctcccca atggacagct                                        90


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 FW

<400>  9
ggacaacccc aaagtacccc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 RV

<400>  10
aggatcagtg aaacgcacca                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NAV1.7 FW

<400>  11
gccagtgggt tcagtggtat                                                   20


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NAV1.7 RV

<400>  12
tcagcattat ccttgcattt tctgt                                             25


<210>  13
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  VEGFA

<400>  13
auucccucuu uagccagagc guuuuaguac ucuggaaaca gaaucuacua aaacaaggca       60

aaaugccgug uuuaucucgu caacuuguug gcgagauuuu                            100


<210>  14
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  EMX1

<400>  14
caaccacaaa cccacgaggg guuuuaguac ucuggaaaca gaaucuacua aaacaaggca       60

aaaugccgug uuuaucucgu caacuuguug gcgagauuuu                            100


<210>  15
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  FANCF

<400>  15
caaggcccgg cgcacggugg guuuuaguac ucuggaaaca gaaucuacua aaacaaggca       60

aaaugccgug uuuaucucgu caacuuguug gcgagauuuu                            100


<210>  16
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RUNX

<400>  16
aaagagagau guagggcuag guuuuaguac ucuggaaaca gaaucuacua aaacaaggca       60

aaaugccgug uuuaucucgu caacuuguug gcgagauuuu                            100


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFA FW

<400>  17
agacgttcct tagtgctggc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFA RV

<400>  18
aggagggagc aggaaagtga                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFA SEQ

<400>  19
attccctctt tagccagagc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EMX1 FW

<400>  20
tggctgtcca ggcactgctc                                                   20


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EMX1 RV

<400>  21
ggcctgtcct ccctcaag                                                     18


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EMX1 SEQ

<400>  22
caaccacaaa cccacgaggg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FANCF FW

<400>  23
acacggataa agacgctggg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FANCF RV

<400>  24
acacggataa agacgctggg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FANCF SEQ

<400>  25
caaggcccgg cgcacggtgg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RUNX1 FW

<400>  26
aacccagcat agtggtcagc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RUNX1 RV

<400>  27
tctgtgcatg tgcctgctaa                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RUNX1 SEQ

<400>  28
aaagagagat gtagggctag                                                   20


