                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Disrupting the LINC complex for treating Laminopathy

<130>  SP100397WO

<150>  10201800530Q
<151>  2018-01-19

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  15424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pAdDeltaF6

<400>  1
tcgacggtat cgataagctt gatatcgaat tcctgcagcc cgggggatcc actagttcta       60

gagcggccgc caccgcggtg gagctccagc ttttgttccc tttagtgagg gttaatttcg      120

agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt      180

ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc      240

taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc      300

cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct      360

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      420

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      480

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      540

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      600

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      660

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      720

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      780

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      840

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      900

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      960

aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc     1020

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     1080

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     1140

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     1200

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     1260

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1320

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1380

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1440

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1500

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1560

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1620

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1680

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1740

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1800

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1860

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1920

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1980

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     2040

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     2100

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     2160

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     2220

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     2280

gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt     2340

atcacgaggc cctttcgtct tcaagaattc tcatgtttga cagcttatca tcgataagct     2400

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2460

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2520

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     2580

tcactatggc gtgctgctag cgctatatgc gttgatgcaa tttctatgcg cacccgttct     2640

cggagcactg tccgaccgct ttggccgccg cccagtcctg ctcgcttcgc tacttggagc     2700

cactatcgac tacgcgatca tggcgaccac acccgtcctg tggatccggc gcacaccaaa     2760

aacgtcactt ttgccacatc cgtcgcttac atgtgttccg ccacacttgc aacatcacac     2820

ttccgccaca ctactacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc     2880

caccccctca ttatcatatt ggcttcaatc caaaataaat catcaataat ataccttatt     2940

ttggattgaa gccaatatga taatgagggg gtggagtttg tgacgtggcg cggggcgtgg     3000

gaacggggcg ggtgacgtag gttttagggc ggagtaactt gtatgtgttg ggaattgtag     3060

ttttcttaaa atgggaagtt acgtaacgtg ggaaaacgga agtgacgatt tgaggaagtt     3120

gtgggttttt tggctttcgt ttctgggcgt aggttcgcgt gcggttttct gggtgttttt     3180

tgtggacttt aaccgttacg tcatttttta gtcctatata tactcgctct gcacttggcc     3240

cttttttaca ctgtgactga ttgagctggt gccgtgtcga gtggtgtttt tttaataggt     3300

tttctttttt actggtaagg ctgactgtta ggctgccgct gtgaagcgct gtatgttgtt     3360

ctggagcggg agggtgctat tttgcctagg caggagggtt tttcaggtgt ttatgtgttt     3420

ttctctccta ttaattttgt tatacctcct atgggggctg taatgttgtc tctacgcctg     3480

cgggtatgta ttcccccggg ctatttcggt cgctttttag cactgaccga tgaatcaacc     3540

tgatgtgttt accgagtctt acattatgac tccggacatg accgaggagc tgtcggtggt     3600

gctttttaat cacggtgacc agttttttta cggtcacgcc ggcatggccg tagtccgtct     3660

tatgcttata agggttgttt ttcctgttgt aagacaggct tctaatgttt aaatgttttt     3720

ttgttatttt attttgtgtt tatgcagaaa cccgcagaca tgtttgagag aaaaatggtg     3780

tctttttctg tggtggttcc ggagcttacc tgcctttatc tgcatgagca tgactacgat     3840

gtgctttctt ttttgcgcga ggctttgcct gattttttga gcagcacctt gcattttata     3900

tcgccgccca tgcaacaaag cttacatcgg ggctacgctg gttagcatag ctccgagtat     3960

gcgtgtcata atcagtgtgg gttcttttgt caaggttcct ggcggggaag tggccgcgct     4020

ggtccgtgca gacctgcacg attatgttca gctggccctg cgaagggacc tacgggatcg     4080

cggtattttt gttaatgttc cgcttttgaa tcttatacag gtctgtgagg aacctgaatt     4140

tttgcaatca tgattcgctg cttgaggctg aaggtggagg gcgctctgga gcagattttt     4200

acaatggccg gacttaatat tcgggatttg cttagagata tattgagaag gtggcgagat     4260

gagaattatt tgggcatggt tgaaggtgct ggaatgttta tagaggagat tcaccctgaa     4320

gggtttagcc tttacgtcca cttggacgtg agggccgttt gccttttgga agccattgtg     4380

caacatctta caaatgccat tatctgttct ttggctgtag agtttgacca cgccaccgga     4440

ggggagcgcg ttcacttaat agatcttcat tttgaggttt tggataatct tttggaataa     4500

aaaaaaaaac atggttcttc cagctcttcc cgctcctccc gtgtgtgact cgcagaacga     4560

atgtgtaggt tggctgggtg tggcttattc tgcggtggtg gatgttatca gggcagcggc     4620

gcatgaagga gtttacatag aacccgaagc cagggggcgc ctggatgctt tgagagagtg     4680

gatatactac aactactaca cagagcgatc taagcggcga gaccggagac gcagatctgt     4740

ttgtcacgcc cgcacctggt tttgcttcag gaaatatgac tacgtccggc gttccatttg     4800

gcatgacact acgaccaaca cgatctcggt tgtctcggcg cactccgtac agtagggatc     4860

gtctacctcc ttttgagaca gaaacccgcg ctaccatact ggaggatcat ccgctgctgc     4920

ccgaatgtaa cactttgaca atgcacaacg tgagttacgt gcgaggtctt ccctgcagtg     4980

tgggatttac gctgattcag gaatgggttg ttccctggga tatggttcta acgcgggagg     5040

agcttgtaat cctgaggaag tgtatgcacg tgtgcctgtg ttgtgccaac attgatatca     5100

tgacgagcat gatgatccat ggttacgagt cctgggctct ccactgtcat tgttccagtc     5160

ccggttccct gcagtgtata gccggcgggc aggttttggc cagctggttt aggatggtgg     5220

tggatggcgc catgtttaat cagaggttta tatggtaccg ggaggtggtg aattacaaca     5280

tgccaaaaga ggtaatgttt atgtccagcg tgtttatgag gggtcgccac ttaatctacc     5340

tgcgcttgtg gtatgatggc cacgtgggtt ctgtggtccc cgccatgagc tttggataca     5400

gcgccttgca ctgtgggatt ttgaacaata ttgtggtgct gtgctgcagt tactgtgctg     5460

atttaagtga gatcagggtg cgctgctgtg cccggaggac aaggcgcctt atgctgcggg     5520

cggtgcgaat catcgctgag gagaccactg ccatgttgta ttcctgcagg acggagcggc     5580

ggcggcagca gtttattcgc gcgctgctgc agcaccaccg ccctatcctg atgcacgatt     5640

atgactctac ccccatgtag gcgtggactt ctccttcgcc gcccgttaag caaccgcaag     5700

ttggacagca gcctgtggct cagcagctgg acagcgacat gaacttaagt gagctgcccg     5760

gggagtttat taatatcact gatgagcgtt tggctcgaca ggaaaccgtg tggaatataa     5820

cacctaagaa tatgtctgtt acccatgata tgatgctttt taaggccagc cggggagaaa     5880

ggactgtgta ctctgtgtgt tgggagggag gtggcaggtt gaatactagg gttctgtgag     5940

tttgattaag gtacggtgat ctgtataagc tatgtggtgg tggggctata ctactgaatg     6000

aaaaatgact tgaaattttc tgcaattgaa aaataaacac gttgaaacat aacacaaacg     6060

attctttatt cttgggcaat gtatgaaaaa gtgtaagagg atgtggcaaa tatttcatta     6120

atgtagttgt ggccagacca gtcccatgaa aatgacatag agtatgcact tggagttgtg     6180

tctcctgttt cctgtgtacc gtttagtgta atggttagtg ttacaggttt agttttgtct     6240

ccgtttaagt aaacttgact gacaatgtta cttttggcag ttttaccgtg agattttgga     6300

taagctgata ggttaggcat aaatccaaca gcgtttgtat aggctgtgcc ttcagtaaga     6360

tctccatttc taaagttcca atattctggg tccaggaagg aattgtttag tagcactcca     6420

ttttcgtcaa atcttataat aagatgagca ctttgaactg ttccagatat tggagccaaa     6480

ctgcctttaa cagccaaaac tgaaactgta gcaagtattt gactgccaca ttttgttaag     6540

accaaagtga gtttagcatc tttctctgca tttagtctac agttaggaga tggagctggt     6600

gtggtccaca aagttagctt atcattattt ttgtttccta ctgtaatggc acctgtgctg     6660

tcaaaactaa ggccagttcc tagtttagga accatagcct tgtttgaatc aaattctagg     6720

ccatggccaa tttttgtttt gaggggattt gtgtttggtg cattaggtga accaaattca     6780

agcccatctc ctgcattaat ggctatggct gtagcgtcaa acatcaaccc cttggcagtg     6840

cttaggttaa cctcaagctt tttggaattg tttgaagctg taaacaagta aaggcctttg     6900

ttgtagttaa tatccaagtt gtgggctgag tttataaaaa gagggccctg tcctagtctt     6960

agatttagtt ggttttgagc atcaaacgga taactaacat caagtataag gcgtctgttt     7020

tgagaatcaa tccttagtcc tcctgctaca ttaagttgca tattgccttg tgaatcaaaa     7080

cccaaggctc cagtaacttt agtttgcaag gaagtattat taatagtcac acctggacca     7140

gttgctacgg tcaaagtgtt taggtcgtct gttacatgca aaggagcccc gtactttagt     7200

cctagttttc cattttgtgt ataaatgggc tctttcaagt caatgcccaa gctaccagtg     7260

gcagtagtta gagggggtga ggcagtgata gtaagggtac tgctatcggt ggtggtgagg     7320

gggcctgatg tttgcagggc tagctttcct tctgacactg tgaggggtcc ttgggtggca     7380

atgctaagtt tggagtcgtg cacggttagc ggggcctgtg attgcatggt gagtgtgttg     7440

cccgcgacca ttagaggtgc ggcggcagcc acagttaggg cttctgaggt aactgtgagg     7500

ggtgcagata tttccaggtt tatgtttgac ttggtttttt tgagaggtgg gctcacagtg     7560

gttacatttt gggaggtaag gttgccggcc tcgtccagag agaggccgtt gcccattttg     7620

agcgcaagca tgccattgga ggtaactaga ggttcggata ggcgcaaaga gagtacccca     7680

gggggactct cttgaaaccc attgggggat acaaagggag gagtaagaaa aggcacagtt     7740

ggaggaccgg tttccgtgtc atatggatac acggggttga aggtatcttc agacggtctt     7800

gcgcgcttca tctgcaacaa catgaagata gtgggtgcgg atggacagga acaggaggaa     7860

actgacattc catttagatt gtggagaaag tttgcagcca ggaggaagct gcaataccag     7920

agctgggagg agggcaagga ggtgctgctg aataaactgg acagaaattt gctaactgat     7980

tttaagtaag tgatgcttta ttattttttt ttattagtta aagggaataa gatccccggg     8040

tactctagtt aattaactag aggatcttga tgtaatccaa ggttaggaca gttgcaaatc     8100

acagtgagaa cacagggtcc cctgtcccgc tcaactagca gggggcgctg ggtaaactcc     8160

cgaatcaggc tacgggcaag ctctccctgg gcggtaagcc ggacgccgtg cgccgggccc     8220

tcgatatgat cctcgggcaa ttcaaagtag caaaactcac cggagtcgcg ggcaaagcac     8280

ttgtggcggc gacagtggac caggtgtttc aggcgcagtt gctctgcctc tccacttaac     8340

attcagtcgt agccgtccgc cgagtccttt accgcgtcaa agttaggaat aaattgatcc     8400

ggatagtggc cgggaggtcc cgagaagggg ttaaagtaga ccgatggcac aaactcctca     8460

ataaattgca gagttccaat gcctccagag cgcggctcag aggacgaggt ctgcagagtt     8520

aggattgcct gacgaggcgt gaatgaagga cggccggcgc cgccgatctg aaatgtcccg     8580

tccggacgga gaccaagcga ggagctcacc gactcgtcgt tgagctgaat acctcgccct     8640

ctgattgtca ggtgagttat accctgcccg ggcgaccgca ccctgtgacg aaagccgccc     8700

gcaagctgcg cccctgagtt agtcatctga acttcggcct gggcgtctct gggaagtacc     8760

acagtggtgg gagcgggact ttcctggtac accagggcag cgggccaact acggggatta     8820

aggttattac gaggtgtggt ggtaatagcc gcctgttcca agagaattcg gtttcggtgg     8880

gcgcggattc cgttgacccg ggatatcatg tggggtcccg cgctcatgta gtttattcgg     8940

gttgagtagt cttgggcagc tccagccgca agtcccattt gtggctggta actccacatg     9000

tagggcgtgg gaatttcctt gctcataatg gcgctgacga caggtgctgg cgccgggtgt     9060

ggccgctgga gatgacgtag ttttcgcgct taaatttgag aaagggcgcg aaactagtcc     9120

ttaagagtca gcgcgcagta tttactgaag agagcctccg cgtcttccag cgtgcgccga     9180

agctgatctt cgcttttgtg atacaggcag ctgcgggtga gggatcgcag agacctgttt     9240

tttattttca gctcttgttc ttggcccctg ctctgttgaa atatagcata cagagtggga     9300

aaaatcctgt ttctaagctc gcgggtcgat acgggttcgt tgggcgccag acgcagcgct     9360

cctcctcctg ctgctgccgc cgctgtggat ttcttgggct ttgtcagagt cttgctatcc     9420

ggtcgccttt gcttctgtgt ggccgctgct gttgctgccg ctgccgctgc cgccggtgca     9480

gtatgggctg tagagatgac ggtagtaatg caggatgtta cgggggaagg ccacgccgtg     9540

atggtagaga agaaagcggc gggcgaagga gatgttgccc ccacagtctt gcaagcaagc     9600

aactatggcg ttcttgtgcc cgcgccatga gcggtagcct tggcgctgtt gttgctcttg     9660

ggctaacggc ggcggctgct tggacttacc ggccctggtt ccagtggtgt cccatctacg     9720

gttgggtcgg cgaacgggca gtgccggcgg cgcctgagga gcggaggttg tagccatgct     9780

ggaaccggtt gccgatttct ggggcgccgg cgaggggaat gcgaccgagg gtgacggtgt     9840

ttcgtctgac acctcttcga cctcggaagc ttcctcgtct aggctctccc agtcttccat     9900

catgtcctcc tcctcctcgt ccaaaacctc ctctgcctga ctgtcccagt attcctcctc     9960

gtccgtgggt ggcggcggca gctgcagctt ctttttgggt gccatcctgg gaagcaaggg    10020

cccgcggctg ctgctgatag ggctgcggcg gcggggggat tgggttgagc tcctcgccgg    10080

actgggggtc caagtaaacc ccccgtccct ttcgtagcag aaactcttgg cgggctttgt    10140

tgatggcttg caattggcca agaatgtggc cctgggtaat gacgcaggcg gtaagctccg    10200

catttggcgg gcgggattgg tcttcgtaga acctaatctc gtgggcgtgg tagtcctcag    10260

gtacaaattt gcgaaggtaa gccgacgtcc acagccccgg agtgagtttc aaccccggag    10320

ccgcggactt ttcgtcaggc gagggaccct gcagctcaaa ggtaccgata atttgacttt    10380

cgttaagcag ctgcgaattg caaaccaggg agcggtgcgg ggtgcatagg ttgcagcgac    10440

agtgacactc cagtagaccg tcaccgctca cgtcttccat tatgtcagag tggtaggcaa    10500

ggtagttggc tagctgcaga aggtagcagt ggccccaaag cggcggaggg cattcgcggt    10560

acttaatggg cacaaagtcg ctaggaagtg cacagcaggt ggcgggcaag attcctgagc    10620

gctctaggat aaagttccta aagttctgca acatgctttg actggtgaag tctggcagac    10680

cctgttgcag ggttttaagc aggcgttcgg ggaaaatgat gtccgccagg tgcgcggcca    10740

cggagcgctc gttgaaggcc gtccataggt ccttcaagtt ttgctttagc agtttctgca    10800

gctccttgag gttgcactcc tccaagcact gctgccaaac gcccatggcc gtctgccagg    10860

tgtagcatag aaataagtaa acgcagtcgc ggacgtagtc gcggcgcgcc tcgcccttga    10920

gcgtggaatg aagcacgttt tgcccaaggc ggttttcgtg caaaattcca aggtaggaga    10980

ccaggttgca gagctccacg ttggagatct tgcaggcctg gcgtacgtag ccctgtcgaa    11040

aggtgtagtg caatgtttcc tctagcttgc gctgcatctc cgggtcagca aagaaccgct    11100

gcatgcactc aagctccacg gtaacgagca ctgcggccat cattagtttg cgtcgctcct    11160

ccaagtcggc aggctcgcgc gtttgaagcc agcgcgctag ctgctcgtcg ccaactgcgg    11220

gtaggccctc ctctgtttgt tcttgcaaat ttgcatccct ctccaggggc tgcgcacggc    11280

gcacgatcag ctcactcatg actgtgctca tgaccttggg gggtaggtta agtgccgggt    11340

aggcaaagtg ggtgacctcg atgctgcgtt ttagtacggc taggcgcgcg ttgtcaccct    11400

cgagttccac caacactcca gagtgacttt cattttcgct gttttcctgt tgcagagcgt    11460

ttgccgcgcg cttctcgtcg cgtccaagac cctcaaagat ttttggcact tcgttgagcg    11520

aggcgatatc aggtatgaca gcgccctgcc gcaaggccag ctgcttgtcc gctcggctgc    11580

ggttggcacg gcaggatagg ggtatcttgc agttttggaa aaagatgtga taggtggcaa    11640

gcacctctgg cacggcaaat acggggtaga agttgaggcg cgggttgggc tcgcatgtgc    11700

cgttttcttg gcgtttgggg ggtacgcgcg gtgagaatag gtggcgttcg taggcaaggc    11760

tgacatccgc tatggcgagg ggcacatcgc tgcgctcttg caacgcgtcg cagataatgg    11820

cgcactggcg ctgcagatgc ttcaacagca cgtcgtctcc cacatctagg tagtcgccat    11880

gcctttcgtc cccccgcccg acttgttcct cgtttgcctc tgcgttgtcc tggtcttgct    11940

ttttatcctc tgttggtact gagcggtcct cgtcgtcttc gcttacaaaa cctgggtcct    12000

gctcgataat cacttcctcc tcctcaagcg ggggtgcctc gacggggaag gtggtaggcg    12060

cgttggcggc atcggtggag gcggtggtgg cgaactcaga gggggcggtt aggctgtcct    12120

tcttctcgac tgactccatg atctttttct gcctatagga gaaggaaatg gccagtcggg    12180

aagaggagca gcgcgaaacc acccccgagc gcggacgcgg tgcggcgcga cgtcccccaa    12240

ccatggagga cgtgtcgtcc ccgtccccgt cgccgccgcc tccccgggcg cccccaaaaa    12300

agcggatgag gcggcgtatc gagtccgagg acgaggaaga ctcatcacaa gacgcgctgg    12360

tgccgcgcac acccagcccg cggccatcga cctcggcggc ggatttggcc attgcgccca    12420

agaagaaaaa gaagcgccct tctcccaagc ccgagcgccc gccatcacca gaggtaatcg    12480

tggacagcga ggaagaaaga gaagatgtgg cgctacaaat ggtgggtttc agcaacccac    12540

cggtgctaat caagcatggc aaaggaggta agcgcacagt gcggcggctg aatgaagacg    12600

acccagtggc gcgtggtatg cggacgcaag aggaagagga agagcccagc gaagcggaaa    12660

gtgaaattac ggtgatgaac ccgctgagtg tgccgatcgt gtctgcgtgg gagaagggca    12720

tggaggctgc gcgcgcgctg atggacaagt accacgtgga taacgatcta aaggcgaact    12780

tcaaactact gcctgaccaa gtggaagctc tggcggccgt atgcaagacc tggctgaacg    12840

aggagcaccg cgggttgcag ctgaccttca ccagcaacaa gacctttgtg acgatgatgg    12900

ggcgattcct gcaggcgtac ctgcagtcgt ttgcagaggt gacctacaag catcacgagc    12960

ccacgggctg cgcgttgtgg ctgcaccgct gcgctgagat cgaaggcgag cttaagtgtc    13020

tacacggaag cattatgata aataaggagc acgtgattga aatggatgtg acgagcgaaa    13080

acgggcagcg cgcgctgaag gagcagtcta gcaaggccaa gatcgtgaag aaccggtggg    13140

gccgaaatgt ggtgcagatc tccaacaccg acgcaaggtg ctgcgtgcac gacgcggcct    13200

gtccggccaa tcagttttcc ggcaagtctt gcggcatgtt cttctctgaa ggcgcaaagg    13260

ctcaggtggc ttttaagcag atcaaggctt ttatgcaggc gctgtatcct aacgcccaga    13320

ccgggcacgg tcaccttttg atgccactac ggtgcgagtg caactcaaag cctgggcacg    13380

cgcccttttt gggaaggcag ctaccaaagt tgactccgtt cgccctgagc aacgcggagg    13440

acctggacgc ggatctgatc tccgacaaga gcgtgctggc cagcgtgcac cacccggcgc    13500

tgatagtgtt ccagtgctgc aaccctgtgt atcgcaactc gcgcgcgcag ggcggaggcc    13560

ccaactgcga cttcaagata tcggcgcccg acctgctaaa cgcgttggtg atggtgcgca    13620

gcctgtggag tgaaaacttc accgagctgc cgcggatggt tgtgcctgag tttaagtgga    13680

gcactaaaca ccagtatcgc aacgtgtccc tgccagtggc gcatagcgat gcgcggcaga    13740

acccctttga tttttaaacg gcgcagacgg caagggtggg ggtaaataat cacccgagag    13800

tgtacaaata aaagcatttg cctttattga aagtgtctct agtacattat ttttacatgt    13860

ttttcaagtg acaaaaagaa gtggcgctcc taatctgcgc actgtggctg cggaagtagg    13920

gcgagtggcg ctccaggaag ctgtagagct gttcctggtt gcgacgcagg gtgggctgta    13980

cctggggact gttgagcatg gagttgggta ccccggtaat aaggttcatg gtggggttgt    14040

gatccatggg agtttggggc cagttggcaa aggcgtggag aaacatgcag cagaatagtc    14100

cacaggcggc cgagttgggc ccctgtacgc tttgggtgga cttttccagc gttatacagc    14160

ggtcggggga agaagcaatg gcgctacggc gcaggagtga ctcgtactca aactggtaaa    14220

cctgcttgag tcgctggtca gaaaagccaa agggctcaaa gaggtagcat gtttttgagt    14280

gcgggttcca ggcaaaggcc atccagtgta cgcccccagt ctcggtccga gactcgaacc    14340

gggggtcccg cgactcaacc cttggaaaat aaccctccgg ctacagggag cgagccactt    14400

aatgctttcg ctttccagcc taaccgctta cgctgcgcgc ggccagtggc caaaaaagct    14460

agcgcagcag ccgccgcgcc tggaaggaag ccaaaaggag cactcccccg ttgtctgacg    14520

tcgcacacct gggttcgaca cgcgggcggt aaccgcatgg atcacggcgg acggccggat    14580

acggggctcg aaccccggtc gtccgccatg atacccttgc gaatttatcc accagaccac    14640

ggaagagtgc ccgcttacag gctctccttt tgcacggtag agcgtcaacg attgcgcgcg    14700

cctgaccggc cagagcgtcc cgaccatgga gcactttttg ccgctgcgca acatctggaa    14760

ccgcgtccgc gactttccgc gcgcctccac caccgccgcc ggcatcacct ggatgtccag    14820

gtacatctac ggatatcatc gccttatgtt ggaagatctc gcccccggag ccccggccac    14880

cctacgctgg cccctctacc gccagccgcc gccgcacttt ttggtgggat accagtacct    14940

ggtgcggact tgcaacgact acgtatttga ctcgagggct tactcgcgtc tcaggtacac    15000

cgagctctcg cagccgggtc accagaccgt taactggtcc gttatggcca actgcactta    15060

caccatcaac acgggcgcat accaccgctt tgtggacatg gatgacttcc agtctaccct    15120

cacgcaggtg cagcaggcca tattagccga gcgcgttgtc gccgacctag ccctgcttca    15180

gccgatgagg ggcttcgggg tcacacgcat gggaggaaga gggcgccacc tacggccaaa    15240

ctccgccgcc gccgcagcga tagatgcaag agatgcagga caagaggaag gagaagaaga    15300

agtgccggta gaaaggctca tgcaagacta ctacaaagac ctgcgccgat gtcaaaacga    15360

agcctggggc atggccgacc gcctgcgcat tcagcaggcc ggacccaagg acatggtgct    15420

tctg                                                                 15424


<210>  2
<211>  7330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pAAV2_9

<400>  2
gtcgacggta tcgggggagc tcgcagggtc tccattttga agcgggaggt ttgaacgcgc       60

agccgccatg ccggggtttt acgagattgt gattaaggtc cccagcgacc ttgacgagca      120

tctgcccggc atttctgaca gctttgtgaa ctgggtggcc gagaaggaat gggagttgcc      180

gccagattct gacatggatc tgaatctgat tgagcaggca cccctgaccg tggccgagaa      240

gctgcagcgc gactttctga cggaatggcg ccgtgtgagt aaggccccgg aggctctttt      300

ctttgtgcaa tttgagaagg gagagagcta cttccacatg cacgtgctcg tggaaaccac      360

cggggtgaaa tccatggttt tgggacgttt cctgagtcag attcgcgaaa aactgattca      420

gagaatttac cgcgggatcg agccgacttt gccaaactgg ttcgcggtca caaagaccag      480

aaatggcgcc ggaggcggga acaaggtggt ggatgagtgc tacatcccca attacttgct      540

ccccaaaacc cagcctgagc tccagtgggc gtggactaat atggaacagt atttaagcgc      600

ctgtttgaat ctcacggagc gtaaacggtt ggtggcgcag catctgacgc acgtgtcgca      660

gacgcaggag cagaacaaag agaatcagaa tcccaattct gatgcgccgg tgatcagatc      720

aaaaacttca gccaggtaca tggagctggt cgggtggctc gtggacaagg ggattacctc      780

ggagaagcag tggatccagg aggaccaggc ctcatacatc tccttcaatg cggcctccaa      840

ctcgcggtcc caaatcaagg ctgccttgga caatgcggga aagattatga gcctgactaa      900

aaccgccccc gactacctgg tgggccagca gcccgtggag gacatttcca gcaatcggat      960

ttataaaatt ttggaactaa acgggtacga tccccaatat gcggcttccg tctttctggg     1020

atgggccacg aaaaagttcg gcaagaggaa caccatctgg ctgtttgggc ctgcaactac     1080

cgggaagacc aacatcgcgg aggccatagc ccacactgtg cccttctacg ggtgcgtaaa     1140

ctggaccaat gagaactttc ccttcaacga ctgtgtcgac aagatggtga tctggtggga     1200

ggaggggaag atgaccgcca aggtcgtgga gtcggccaaa gccattctcg gaggaagcaa     1260

ggtgcgcgtg gaccagaaat gcaagtcctc ggcccagata gacccgactc ccgtgatcgt     1320

cacctccaac accaacatgt gcgccgtgat tgacgggaac tcaacgacct tcgaacacca     1380

gcagccgttg caagaccgga tgttcaaatt tgaactcacc cgccgtctgg atcatgactt     1440

tgggaaggtc accaagcagg aagtcaaaga ctttttccgg tgggcaaagg atcacgtggt     1500

tgaggtggag catgaattct acgtcaaaaa gggtggagcc aagaaaagac ccgcccccag     1560

tgacgcagat ataagtgagc ccaaacgggt gcgcgagtca gttgcgcagc catcgacgtc     1620

agacgcggaa gcttcgatca actacgcgga caggtaccaa aacaaatgtt ctcgtcacgt     1680

gggcatgaat ctgatgctgt ttccctgcag acaatgcgag agactgaatc agaattcaaa     1740

tatctgcttc actcacggtg tcaaagactg tttagagtgc tttcccgtgt cagaatctca     1800

acccgtttct gtcgtcaaaa aggcgtatca gaaactgtgc tacattcatc acatcatggg     1860

aaaggtgcca gacgcttgca ctgcttgcga cctggtcaat gtggacttgg atgactgtgt     1920

ttctgaacaa taaatgactt aaaccaggta tggctgccga tggttatctt ccagattggc     1980

tcgaggacaa ccttagtgaa ggaattcgcg agtggtgggc tttgaaacct ggagcccctc     2040

aacccaaggc aaatcaacaa catcaagaca acgctcgagg tcttgtgctt ccgggttaca     2100

aataccttgg acccggcaac ggactcgaca agggggagcc ggtcaacgca gcagacgcgg     2160

cggccctcga gcacgacaag gcctacgacc agcagctcaa ggccggagac aacccgtacc     2220

tcaagtacaa ccacgccgac gccgagttcc aggagcggct caaagaagat acgtcttttg     2280

ggggcaacct cgggcgagca gtcttccagg ccaaaaagag gcttcttgaa cctcttggtc     2340

tggttgagga agcggctaag acggctcctg gaaagaagag gcctgtagag cagtctcctc     2400

aggaaccgga ctcctccgcg ggtattggca aatcgggtgc acagcccgct aaaaagagac     2460

tcaatttcgg tcagactggc gacacagagt cagtcccaga ccctcaacca atcggagaac     2520

ctcccgcagc cccctcaggt gtgggatctc ttacaatggc ttcaggtggt ggcgcaccag     2580

tggcagacaa taacgaaggt gccgatggag tgggtagttc ctcgggaaat tggcattgcg     2640

attcccaatg gctgggggac agagtcatca ccaccagcac ccgaacctgg gccctgccca     2700

cctacaacaa tcacctctac aagcaaatct ccaacagcac atctggagga tcttcaaatg     2760

acaacgccta cttcggctac agcaccccct gggggtattt tgacttcaac agattccact     2820

gccacttctc accacgtgac tggcagcgac tcatcaacaa caactgggga ttccggccta     2880

agcgactcaa cttcaagctc ttcaacattc aggtcaaaga ggttacggac aacaatggag     2940

tcaagaccat cgccaataac cttaccagca cggtccaggt cttcacggac tcagactatc     3000

agctcccgta cgtgctcggg tcggctcacg agggctgcct cccgccgttc ccagcggacg     3060

ttttcatgat tcctcagtac gggtatctga cgcttaatga tggaagccag gccgtgggtc     3120

gttcgtcctt ttactgcctg gaatatttcc cgtcgcaaat gctaagaacg ggtaacaact     3180

tccagttcag ctacgagttt gagaacgtac ctttccatag cagctacgct cacagccaaa     3240

gcctggaccg actaatgaat ccactcatcg accaatactt gtactatctc tcaaagacta     3300

ttaacggttc tggacagaat caacaaacgc taaaattcag tgtggccgga cccagcaaca     3360

tggctgtcca gggaagaaac tacatacctg gacccagcta ccgacaacaa cgtgtctcaa     3420

ccactgtgac tcaaaacaac aacagcgaat ttgcttggcc tggagcttct tcttgggctc     3480

tcaatggacg taatagcttg atgaatcctg gacctgctat ggccagccac aaagaaggag     3540

aggaccgttt ctttcctttg tctggatctt taatttttgg caaacaagga actggaagag     3600

acaacgtgga tgcggacaaa gtcatgataa ccaacgaaga agaaattaaa actactaacc     3660

cggtagcaac ggagtcctat ggacaagtgg ccacaaacca ccagagtgcc caagcacagg     3720

cgcagaccgg ctgggttcaa aaccaaggaa tacttccggg tatggtttgg caggacagag     3780

atgtgtacct gcaaggaccc atttgggcca aaattcctca cacggacggc aactttcacc     3840

cttctccgct gatgggaggg tttggaatga agcacccgcc tcctcagatc ctcatcaaaa     3900

acacacctgt acctgcggat cctccaacgg ccttcaacaa ggacaagctg aactctttca     3960

tcacccagta ttctactggc caagtcagcg tggagatcga gtgggagctg cagaaggaaa     4020

acagcaagcg ctggaacccg gagatccagt acacttccaa ctattacaag tctaataatg     4080

ttgaatttgc tgttaatact gaaggtgtat atagtgaacc ccgccccatt ggcaccagat     4140

acctgactcg taatctgtaa ttgcttgtta atcaataaac cgtttaattc gtttcagttg     4200

aactttggtc tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt     4260

agaggtcacg tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta     4320

agcccgagtg agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc     4380

aagccgaatt ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc     4440

gcggtggagc tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc     4500

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     4560

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     4620

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     4680

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     4740

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     4800

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     4860

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     4920

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     4980

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     5040

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     5100

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     5160

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     5220

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     5280

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     5340

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     5400

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     5460

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     5520

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     5580

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     5640

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     5700

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     5760

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     5820

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     5880

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     5940

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     6000

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     6060

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     6120

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     6180

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     6240

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     6300

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     6360

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     6420

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     6480

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     6540

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     6600

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctaaatt     6660

gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt     6720

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg     6780

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc     6840

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca     6900

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga     6960

tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa     7020

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc     7080

gccgcgctta atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt     7140

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt     7200

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg     7260

acggccagtg agcgcgcgta atacgactca ctatagggcg aattgggtac cgggcccccc     7320

ctcgatcgag                                                            7330


<210>  3
<211>  5720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pENN.AAV.cTnT.PI.Sun1-dom-neg

<400>  3
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttacgggccc cccctcgagg tcgggataaa      240

agcagtctgg gctttcacat gacagcatct ggggctgcgg cagagggtcg ggtccgaagc      300

gctgccttat cagcgcccca gccctgggag gtgacagctg gctggcttgt gtcagcccct      360

cgggcactca cgtatctccg tccgacgggt ttaaaatagc aaaactctga ggccacacaa      420

tagcttgggc ttatatgggc tcctgtgggg gaagggggag cacggagggg gccggggccg      480

ctgctgccaa aatagcagct cacaagtgtt gcattcctct ctgggcgccg ggcacattcc      540

tgctggctct gcccgccccg gggtgggcgc cggggggacc ttaaagcctc tgccccccaa      600

ggagcccttc ccagacagcc gccggcaccc accgctccgt gggacgatcc ccgaagctct      660

agagctttat tgcggtagtt tatcacagtt aaattgctaa cgcagtcagt gcttctgaca      720

caacagtctc gaacttaagc tgcagaagtt ggtcgtgagg cactgggcag gtaagtatca      780

aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga cagagaagac      840

tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc tttctctcca      900

caggtgtcca ctcccagttc aattacagct cttaaggcta gagtacttaa tacgactcac      960

tataggctag cctcgagaat tcacgcgggc cgccatgaag tgggtaacct ttatttccct     1020

tctttttctc tttagctcgg cctattccag gggtgtgttt cgtcgagatg ggcccgctta     1080

cccttacgat gtaccggatt acgcactcga cgattccaag ggcatgcata gacctggccc     1140

tcttcccccg agcccacctc caaaggttga tcacaaggct tcccagtggc ctcaggagag     1200

tgacatgggg cagaaggtag cttctttgag tgcgcagtgc cacaaccatg atgagagact     1260

tgcagagctg acagtcctgc ttcagaaact acagatacgg gtagaccaag tggatgacgg     1320

cagggaaggg ctgtcactgt gggtcaagaa tgtggttgga cagcacctgc aggagatggg     1380

caccatagaa ccacctgatg ctaagactga cttcatgact ttccaccatg accatgaagt     1440

gcgtctctcc aacttggaag atgttcttag aaaactgaca gaaaaatctg aggctatcca     1500

gaaggagctg gaagaaacca agctgaaagc aggcagcagg gatgaagagc agcccctcct     1560

tgaccgtgtg cagcacctag aactggaact gaacctgttg aagtcacagc tgtcagactg     1620

gcagcatctg aagaccagct gtgagcaggc tggggcccgc atccaggaga ctgtgcagct     1680

catgttctct gaggatcagc agggcggttc cctcgagtgg ctattagaga agctttcttc     1740

tcggttcgtg agcaaggatg agctgcaggt gctcttacat gaccttgagc tgaaactgct     1800

gcagaatatc acacaccaca tcaccgtgac aggacaggcc ccgacatccg aggctattgt     1860

gtctgccgtg aatcaggcag ggatttcagg aatcacagaa gcgcaagcac atatcattgt     1920

gaacaatgct ctgaagctgt actcccaaga caagacgggg atggtggact ttgctctgga     1980

gtctggaggt ggcagcatcc taagcactcg gtgctctgag acctatgaga ccaagacggc     2040

actgctgagc ctgtttgggg tcccactgtg gtacttctca cagtcacctc gagtggtgat     2100

ccagcccgac atctacccag ggaattgctg ggcgttcaaa ggttcccagg ggtacctggt     2160

ggtgcggttg tccatgaaga tctacccaac cacattcacc atggaacaca ttccaaagac     2220

actatcaccc actggtaaca tctccagtgc ccccaaagac tttgcagtct atggactgga     2280

aacggagtat caagaagagg ggcagcctct gggacggttc acctatgacc aggaaggaga     2340

ctcactccag atgttccaca cactggaaag acctgaccaa gccttccaga tagtagagct     2400

ccgggtcctg tccaactggg gccaccctga gtacacttgc ctctaccggt tccgagtcca     2460

cggagagccc atccagaaag atgagttgta gtaaggtacc tctagagtcg acccgggcgg     2520

cctcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     2580

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     2640

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaagcaatt cgttgatctg     2700

aatttcgacc acccataata cccattaccc tggtagataa gtagcatggc gggttaatca     2760

ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     2820

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     2880

tgagcgagcg agcgcgcagc cttaattaac ctaattcact ggccgtcgtt ttacaacgtc     2940

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     3000

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     3060

tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     3120

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     3180

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     3240

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     3300

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     3360

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     3420

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     3480

tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac     3540

ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat     3600

gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag     3660

tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc     3720

tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc     3780

acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc     3840

cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc     3900

ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt     3960

ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt     4020

atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat     4080

cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct     4140

tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat     4200

gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc     4260

ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg     4320

ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc     4380

tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta     4440

cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc     4500

ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga     4560

tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat     4620

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     4680

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     4740

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     4800

ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt     4860

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt     4920

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata     4980

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt     5040

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac     5100

gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga     5160

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg     5220

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa     5280

aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat     5340

gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc     5400

tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga     5460

agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg     5520

gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta     5580

gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg     5640

aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt acgccagatt     5700

taattaaggc cttaattagg                                                 5720


<210>  4
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized Sun1DN


<220>
<221>  Start codon
<222>  (1)..(3)

<220>
<221>  Signal sequence
<222>  (4)..(84)

<220>
<221>  Sun1
<222>  (88)..(1446)

<220>
<221>  KDEL
<222>  (1447)..(1458)

<220>
<221>  Stop codon
<222>  (1459)..(1461)

<400>  4
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggccta ttccaggggt       60

gtgtttcgtc gagatgggcc cgctctcgat gacccccagg acgtgtttaa acccacgact      120

tctcgcctga agcagcctct gcagggtgac agtgaggctt ttccgtggca ttggatgagt      180

ggcgtggagc agcaggtggc ctctctgtct ggacagtgcc accaccatgg tgagaatctc      240

cgagagctga ccactttgct acagaagctg caggctcggg tggaccagat ggaaggcggc      300

gctgccgggc cgtcagcttc ggtcagagac gctgtgggac agcccccgag ggagactgac      360

tttatggcct ttcaccaaga acatgaagtg cgtatgtcac acttggaaga tattctggga      420

aaactgagag aaaaatctga ggccatccag aaggaactag aacagaccaa gcaaaaaaca      480

atcagtgcgg ttggtgagca gctcctgccc acagtcgagc acctccagct ggagctggat      540

cagctaaagt cagagctgtc cagctggcga cacgtgaaga ccggctgtga gacagtggat      600

gccgtacaag aaagagtgga cgtgcaagtc agagaaatgg tgaaactcct gttttccgaa      660

gatcagcaag gcggttctct ggaacagctg ctgcagaggt tctcatcaca gtttgtgagc      720

aaaggcgact tgcagacgat gctgcgagac ctgcagctgc agatcctgcg gaacgtcacc      780

caccacgttt ccgtgaccaa gcagctccca acctcagaag ccgtggtgtc tgctgtgagc      840

gaggcggggg cgtctggaat aacagaggcg caagcacgtg ccatcgtgaa cagcgccttg      900

aagctgtatt cccaagataa gaccgggatg gtggactttg ctctggaatc tggtggtggc      960

agcatcttga gtactcgctg ttctgaaact tacgaaacca aaacggcgct gatgagtctg     1020

tttgggatcc cgctgtggta cttctcgcag tccccgcgcg tggtcatcca gcctgacatt     1080

taccccggta actgctgggc atttaaaggc tcccaggggt acctggtggt gaggctctcc     1140

atgatgatcc acccagccgc cttcactctg gagcacatcc ctaagacgct gtcgccaaca     1200

ggcaacatca gcagcgcccc caaggacttc gccgtctatg gattagaaaa tgagtatcag     1260

gaagaagggc agcttctggg acagttcacg tatgatcagg atggggagtc gctccagatg     1320

ttccaggccc tgaaaagacc cgacgacaca gctttccaaa tagtggaact tcggattttt     1380

tctaactggg gccatcctga gtatacctgt ctgtatcggt tcagagttca tggcgaacct     1440

gtcaagaaag atgagttgtg a                                               1461


<210>  5
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUN2


<220>
<221>  Start codon
<222>  (1)..(3)

<220>
<221>  Signal sequence
<222>  (4)..(84)

<220>
<221>  Sun2
<222>  (88)..(1467)

<220>
<221>  KDEL
<222>  (1468)..(1479)

<220>
<221>  Stop codon
<222>  (1480)..(1482)

<400>  5
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggccta ttccaggggt       60

gtgtttcgtc gagatgggcc cgctctcgat gagggctggg aagccagaga ctcatcgcca      120

catttccagg ctgagcagcg tgttatgtcc cgggtacact ctctggagcg gcgtctggaa      180

gctcttgctg ctgaattttc ctccaactgg cagaaggagg ccatgcggct ggaacgtctg      240

gagctgcggc aaggggctcc tggccaggga ggtggtggtg gcctgagcca cgaggacacc      300

ctggcgctgc tggaggggct agtgagccgc cgtgaagctg ccctgaagga ggatttccgc      360

agggaaactg ctgctcgcat ccaggaagaa ctgtctgccc tgagagcaga gcatcagcaa      420

gactcagaag acctcttcaa gaagatcgtc cgggcctccc aggagtccga ggctcgcatc      480

cagcagctga agtcagagtg gcaaagcatg acccaggagt ccttccagga gagctctgtg      540

aaggagctga ggcggctgga ggaccagctg gccggcctgc agcaggagct ggcggctctg      600

gcactgaagc agagctcggt ggcggaagaa gtgggcctgc tgccccagca gatccaggcc      660

gtgcgggacg acgtggaatc tcagttcccg gcctggatca gtcagttcct tgcccgaggt      720

ggagggggcc gcgtggggct ccttcagaga gaggagatgc aagctcagct gcgagagctg      780

gagagcaaga tcctcaccca tgtggcagag atgcagggca agtcggccag ggaagccgcg      840

gcctccctga gcctgacgct gcagaaagaa ggtgtgattg gagtgacaga ggagcaggtg      900

caccacatcg tgaagcaggc cctgcagcgc tacagtgagg accgcatcgg gctggcagac      960

tacgccctgg agtcaggagg ggccagcgtc atcagcaccc gatgttctga gacctacgag     1020

accaagacgg ccctcctcag cctcttcggc atccccctgt ggtaccactc ccagtcaccc     1080

cgagtcatcc tccagccaga tgtgcaccca ggcaactgct gggccttcca ggggccacaa     1140

ggcttcgccg tggtccgcct ctctgcccgc atccgcccca cagccgttac cttagagcat     1200

gtgcccaagg ccttgtcacc caacagcact atctccagtg cccccaagga cttcgccatc     1260

tttgggtttg acgaagacct gcagcaggag gggacactcc ttggcaagtt cacttacgat     1320

caggacggcg agcctattca gacgtttcac tttcaggccc ctacgatggc cacgtaccag     1380

gtggtggagc tgcggatcct gactaactgg ggccaccccg agtacacctg catctaccgc     1440

ttcagagtgc atggggagcc cgcccacaaa gatgagttgt ag                        1482


<210>  6
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH1, derived from Nesprin-1

<400>  6
cgcggcttcc tgttcagagt cctccgagca gctcttcccc ttcagcttct cctgctcctc       60

ctcatcgggc ttgcctgcct tgtaccaatg tcagaggaag actacagctg tgccctctcc      120

aacaactttg cccggtcatt ccaccccatg ctcagataca cgaatggccc tcctccactc      180


<210>  7
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH1 amino acid sequence

<400>  7

Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser Glu 
            20                  25                  30          


Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe His 
        35                  40                  45              


Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
    50                  55                  60  


<210>  8
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH2, derived from Nesprin-2

<400>  8
cgctccttcc tctcaagggt ggtccgggca gccctacccc tgcagctgct cctcctgctg       60

ctgctgctcc tggcctgcct gctgccctcc tccgaagaag actacagctg cactcaggcc      120

aacaactttg cccggtcctt ttaccccatg ctgaggtaca ccaatgggcc accccccaca      180


<210>  9
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH2 amino acid sequence

<400>  9

Arg Ser Phe Leu Ser Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu 
            20                  25                  30          


Glu Asp Tyr Ser Cys Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr 
        35                  40                  45              


Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Thr 
    50                  55                  60  


<210>  10
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH3, derived from Nesprin-3

<400>  10
ggctccctct tccggagggc gtgctgtgtg gcgctcccac tgcagctgct tctgctgctg       60

ttcctcctcc tgctgttcct gctcccaatc agggaagagg accgcagctg caccctggcc      120

aacaacttcg cccgctcctt cacgctcatg ctgcgctaca atggcccacc acccacc         177


<210>  11
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH3 amino acid sequence

<400>  11

Gly Ser Leu Phe Arg Arg Ala Cys Cys Val Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Leu Leu Leu Phe Leu Leu Pro Ile Arg Glu 
            20                  25                  30          


Glu Asp Arg Ser Cys Thr Leu Ala Asn Asn Phe Ala Arg Ser Phe Thr 
        35                  40                  45              


Leu Met Leu Arg Tyr Asn Gly Pro Pro Pro Thr 
    50                  55                  


<210>  12
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH4, derived from Nesprin-4

<400>  12
gatcctgcat ccaggcagcc tctgaccttc ctccttatcc tcttcctcct cttcctcctc       60

ctggtgggtg ccatgtttct cctgcccgcg tcaggaggcc cctgctgctc tcatgcccga      120

atacccagga caccctacct ggtgctcagc tatgtcaatg gtcttccccc agtc            174


<210>  13
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH4 amino acid sequence

<400>  13

Asp Pro Ala Ser Arg Gln Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu 
1               5                   10                  15      


Leu Phe Leu Leu Leu Val Gly Ala Met Phe Leu Leu Pro Ala Ser Gly 
            20                  25                  30          


Gly Pro Cys Cys Ser His Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val 
        35                  40                  45              


Leu Ser Tyr Val Asn Gly Leu Pro Pro Val 
    50                  55              


<210>  14
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH5, derived from CCDC155/KASH5

<400>  14
ctcagagtca ctcgacatcc actgatccca gctcctgtcc tgggcctgct gctgctgctg       60

ctgctctctg tcctgctgct tggcccgtcc ccacctccca cctggcccca cctccagctc      120

tgctacctcc agccccctcc agtg                                             144


<210>  15
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH5 amino acid sequence

<400>  15

Leu Arg Val Thr Arg His Pro Leu Ile Pro Ala Pro Val Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ser Val Leu Leu Leu Gly Pro Ser Pro Pro 
            20                  25                  30          


Pro Thr Trp Pro His Leu Gln Leu Cys Tyr Leu Gln Pro Pro Pro Val 
        35                  40                  45              


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLX/FLX-F1 primer

<400>  16
ccagcttaca gagcaccgag ct                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLX/FLX-F2 primer

<400>  17
tccttgcagt ccctcttgca tc                                                22


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLX/FLX-R1 primer

<400>  18
aggcaccatt gtcacagggt c                                                 21


<210>  19
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1-F primer

<400>  19
ggcaagtgga tctcttgtga attcttgac                                         29


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1-R primer

<400>  20
gtagcaccca ccttggtgag ctggtac                                           27


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1-E8 primer

<400>  21
agccacataa ccacctggag                                                   20


<210>  22
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-tF primer

<400>  22
atgacagaca gatccctcct atctcc                                            26


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-tR primer

<400>  23
ctcatcactc gttgcatcat cgac                                              24


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-F primer

<400>  24
caaatgttgc ttgtctggtg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-R primer

<400>  25
gtcagtcgag tgcacagttt                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-3798t primer

<400>  26
aggtggacct gatcatggag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-8346t primer

<400>  27
ataccggaga tcatgcaagc                                                   20


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-7338 primer

<400>  28
ctaggccaca gaattgaaag atct                                              24


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-7339 primer

<400>  29
gtaggtggaa attctagcat catcc                                             25


<210>  30
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aav Sun1 F primer

<400>  30
cgagaattca cgcgggccgc catgaagtgg gtaaccttta tttc                        44


<210>  31
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aav Sun1 R primer

<400>  31
cgggtcgact ctagaggtac cttactacaa ctcatctttc tggatg                      46


<210>  32
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aav GFP Sun R primer

<400>  32
cgggtcgact ctagaggtac ttactacaac tcatctttgg atcc                        44


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1 delSUN RNA guide sequence

<400>  33
gcacaatagc ctcggatgtc g                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1-stop guide RNA sequence

<400>  34
ccgttggtat atctgagcat                                                   20


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tyrosinase4a guide RNA sequence

<400>  35
ggttatggcc gataggtgca t                                                 21


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Common reverse primer for in vitro transcription

<400>  36
aaaagcaccg actcggtgcc                                                   20


<210>  37
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   Sun1delSUN gRNA-specific forward primer

<400>  37
ttaatacgac tcactatagc acaatagcct cggatgtcg                              39


<210>  38
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1-stop gRNA-specific forward primer

<400>  38
ttaatacgac tcactatagc cgttggtata tctgagcat                              39


<210>  39
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tyrosinase4a gRNA-specific forward primer

<400>  39
ttaatacgac tcactatagg ttatggccga taggtgcat                              39


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1CT' del8 forward primer

<400>  40
tgctcctgct gctgcttatt                                                   20


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1CT' del8 reverse primer

<400>  41
acatggtgga gcatttgtct cc                                                22


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1 CRISPR forward primer

<400>  42
tgaccttgag ctgaaactgc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1 CRISPR reverse primer

<400>  43
tcagaacact ggcacacaca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  44
tcgtgtatct gagcatgggg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  45
gccattcgtg tatctgagca                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  46
tccaccccat gctcagatac                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  47
gagcatgggg tggaatgacc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  48
tgagcatggg gtggaatgac                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  49
tcgtgtatct gagcatgggg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  50
cattcgtgta tctgagcatg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  51
ccattcgtgt atctgagcat                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  52
gccattcgtg tatctgagca                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  53
cccatgctca gatacacgaa                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  54
cccggtcatt ccaccccatg                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  55
tttttctaac tggggccatc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  56
ccgatacaga caggtatact                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  57
aacttcggat tttttctaac                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  58
acttcggatt ttttctaact                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  59
cttcggattt tttctaactg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  60
acagacaggt atactcagga                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  61
ctgagtatac ctgtctgtat                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  62
ttctaactgg ggccatcctg                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  63
tctaactggg gccatcctga                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  64
ctaactgggg ccatcctgag                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  65
taactggggc catcctgagt                                                   20


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 mRNA and gRNA targeting SUN1 domain

<400>  66
gcacaatagc ctcggatgtc g                                                 21


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 mRNA and gRNA targeting the KASH1 domain

<400>  67
ccgttggtat atctgagcat                                                   20


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA targeting tyrosinase

<400>  68
ggttatggcc gataggtgca t                                                 21


<210>  69
<211>  176
<212>  DNA
<213>  Mus musculus

<400>  69
catgaccttg agctgaaact gctgcagaat atcacacacc acatcaccgt gacaggacag       60

gccccgacat ccgaggctat tgtgtctgcc gtgaatcagg cagggatttc aggaatcaca      120

gaagcgcaag cacatatcat tgtgaacaat gctctgaagc tgtactccca agacaa          176


<210>  70
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1_plus4

<400>  70
catgaccttg agctgaaact gctgcagaat atcacacacc acatcaccgt gacaggacag       60

gccccgagac acatccgagg ctattgtgtc tgccgtgaat caggcaggga tttcaggaat      120

cacagaagcg caagcacata tcattgtgaa caatgctctg aagctgtact cccaagacaa      180


<210>  71
<211>  169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1_del7

<400>  71
catgaccttg agctgaaact gctgcagaat atcacacacc acatcaccgt gacaggacag       60

gccccgaggc tattgtgtct gccgtgaatc aggcagggat ttcaggaatc acagaagcgc      120

aagcacatat cattgtgaac aatgctctga agctgtactc ccaagacaa                  169


<210>  72
<211>  253
<212>  PRT
<213>  Mus musculus

<400>  72

Trp Leu Leu Glu Lys Leu Ser Ser Arg Phe Val Ser Lys Asp Glu Leu 
1               5                   10                  15      


Gln Val Leu Leu His Asp Leu Glu Leu Lys Leu Leu Gln Asn Ile Thr 
            20                  25                  30          


His His Ile Thr Val Thr Gly Gln Ala Pro Thr Ser Glu Ala Ile Val 
        35                  40                  45              


Ser Ala Val Asn Gln Ala Gly Ile Ser Gly Ile Thr Glu Ala Gln Ala 
    50                  55                  60                  


His Ile Ile Val Asn Asn Ala Leu Lys Leu Tyr Ser Gln Asp Lys Thr 
65                  70                  75                  80  


Gly Met Val Asp Phe Ala Leu Glu Ser Gly Gly Gly Ser Ile Leu Ser 
                85                  90                  95      


Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Leu Ser Leu 
            100                 105                 110         


Phe Gly Val Pro Leu Trp Tyr Phe Ser Gln Ser Pro Arg Val Val Ile 
        115                 120                 125             


Gln Pro Asp Ile Tyr Pro Gly Asn Cys Trp Ala Phe Lys Gly Ser Gln 
    130                 135                 140                 


Gly Tyr Leu Val Val Arg Leu Ser Met Lys Ile Tyr Pro Thr Thr Phe 
145                 150                 155                 160 


Thr Met Glu His Ile Pro Lys Thr Leu Ser Pro Thr Gly Asn Ile Ser 
                165                 170                 175     


Ser Ala Pro Lys Asp Phe Ala Val Tyr Gly Leu Glu Thr Glu Tyr Gln 
            180                 185                 190         


Glu Glu Gly Gln Pro Leu Gly Arg Phe Thr Tyr Asp Gln Glu Gly Asp 
        195                 200                 205             


Ser Leu Gln Met Phe His Thr Leu Glu Arg Pro Asp Gln Ala Phe Gln 
    210                 215                 220                 


Ile Val Glu Leu Arg Val Leu Ser Asn Trp Gly His Pro Glu Tyr Thr 
225                 230                 235                 240 


Cys Leu Tyr Arg Phe Arg Val His Gly Glu Pro Ile Gln 
                245                 250             


<210>  73
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sun1_plus4 protein

<400>  73

Trp Leu Leu Glu Lys Leu Ser Ser Arg Phe Val Ser Lys Asp Glu Leu 
1               5                   10                  15      


Gln Val Leu Leu His Asp Leu Glu Leu Lys Leu Leu Gln Asn Ile Thr 
            20                  25                  30          


His His Ile Thr Val Thr Gly Gln Ala Pro Arg His Ile Arg Gly Tyr 
        35                  40                  45              


Cys Val Cys Arg Glu Ser Gly Arg Asp Phe Arg Asn His Arg Ser Ala 
    50                  55                  60                  


Ser Thr Tyr His Cys Glu Gln Cys Ser Glu Ala Val Leu Pro Arg Gln 
65                  70                  75                  80  


Asp Gly Asp Gly Gly Leu Cys Ser Gly Val Trp Arg Trp Gln His Pro 
                85                  90                  95      


Lys His Ser Val Leu 
            100     


<210>  74
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sun1_del7 protein

<400>  74

Trp Leu Leu Glu Lys Leu Ser Ser Arg Phe Val Ser Lys Asp Glu Leu 
1               5                   10                  15      


Gln Val Leu Leu His Asp Leu Glu Leu Lys Leu Leu Gln Asn Ile Thr 
            20                  25                  30          


His His Ile Thr Val Thr Gly Gln Ala Pro Arg Leu Leu Cys Leu Pro 
        35                  40                  45              


<210>  75
<211>  180
<212>  DNA
<213>  Mus musculus

<400>  75
tattggactc acctgccttg tacccatgtc agagaaagac tacagctgtg ccctctccaa       60

caactttgcc cgatccttcc atccgatgct cagatatacc aacggtcctc ctccactctg      120

aagcaagcag acatccccac acaagtgcag gcagtaagag gagaaggaat atcaaatggc      180


<210>  76
<211>  172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1_CTdel8

<400>  76
tattggactc acctgccttg tacccatgtc agagaaagac tacagctgtg ccctctccaa       60

caactttgcc cgatccttcc atccgatata ccaacggtcc tcctccactc tgaagcaagc      120

agacatcccc acacaagtgc aggcagtaag aggagaagga atatcaaatg gc              172


<210>  77
<211>  79
<212>  PRT
<213>  Mus musculus

<400>  77

Ser Thr Arg Asp Gly Ser Asp Ser Ser Arg Ser Asp Pro Arg Pro Glu 
1               5                   10                  15      


Arg Val Gly Arg Ala Phe Leu Phe Arg Ile Leu Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gln Leu Leu Leu Leu Leu Leu Ile Gly Leu Thr Cys Leu Val Pro 
        35                  40                  45              


Met Ser Glu Lys Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg 
    50                  55                  60                  


Ser Phe His Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
65                  70                  75                  


<210>  78
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesprin1_CTdel8

<400>  78

Ser Thr Arg Asp Gly Ser Asp Ser Ser Arg Ser Asp Pro Arg Pro Glu 
1               5                   10                  15      


Arg Val Gly Arg Ala Phe Leu Phe Arg Ile Leu Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gln Leu Leu Leu Leu Leu Leu Ile Gly Leu Thr Cys Leu Val Pro 
        35                  40                  45              


Met Ser Glu Lys Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg 
    50                  55                  60                  


Ser Phe His Pro Ile Tyr Gln Arg Ser Ser Ser Thr Leu Lys Gln Ala 
65                  70                  75                  80  


Asp Ile Pro Thr Gln Val Gln Ala Val Arg Gly Glu Gly Ile Ser Asn 
                85                  90                  95      


Gly Arg Glu Ala Pro Lys Glu Lys Phe Asn Ile Leu Asn His Gln Gly 
            100                 105                 110         


Asn Ala Asn Gln Asn Asn Pro Glu Met Glu Thr Asn Ala Pro Pro Cys 
        115                 120                 125             


Ser 
    


<210>  79
<211>  183
<212>  DNA
<213>  Homo sapiens

<400>  79
cgcggcttcc tgttcagagt cctccgagca gctcttcccc ttcagcttct cctgctcctc       60

ctcatcgggc ttgcctgcct tgtaccaatg tcagaggaag actacagctg tgccctctcc      120

aacaactttg cccggtcatt ccaccccatg ctcagataca cgaatggccc tcctccactc      180

tga                                                                    183


<210>  80
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  80
gataagaccg ggatggtgga ctttgctctg gaatctggtg gtggcagcat cttgagtact       60

cgctgttctg aaacttacga aaccaaaacg gcgctgatga gtctgtttgg gatcccgctg      120

tggtacttct cgcagtcccc gcgcgtggtc atccagcctg acatttaccc cggtaactgc      180

tgggcattta aaggctccca ggggtacctg gtggtgaggc tctccatgat gatccaccca      240

gccgccttca ctctggagca catccctaag acgctgtcgc caacaggcaa catcagcagc      300

gcccccaagg acttcgccgt ctatggatta gaaaatgagt atcaggaaga agggcagctt      360

ctgggacagt tcacgtatga tcaggatggg gagtcgctcc agatgttcca ggccctgaaa      420

agacccgacg acacagcttt ccaaatagtg gaacttcgga ttttttctaa ctggggccat      480

cctgagtata cctgtctgta tcggttcaga gttcatggcg aacctgtcaa gtga            534


<210>  81
<211>  117
<212>  DNA
<213>  Homo sapiens

<400>  81
aaaagacccg acgacacagc tttccaaata gtggaacttc ggattttttc taactggggc       60

catcctgagt atacctgtct gtatcggttc agagttcatg gcgaacctgt caagtga         117


