                         SEQUENCE LISTING

<110>  ƼҽҩϺ޹˾;
             Ϻо
 
<120>  SynNotchرIL12

<130>  P19400153C

<150>  CN201810053219.6
<151>  2018-01-19

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ź

<400>  1
atggcgctcc ctgtcaccgc actgcttctt ccgctggcac tgctgctgca cgctgcacgg       60

cct                                                                     63


<210>  2
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GPC3-scFv

<400>  2
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcagc gactacgaga tgcactgggt gcggcaggcc      120

cccggccagg gcctggagtg gatgggcgcc atccaccccg gcagcggcga caccgcctac      180

aaccagcggt tcaagggccg ggtgaccatc accgccgaca agagcaccag caccgcctac      240

atggagctga gcagcctgcg gagcgaggac accgccgtgt actactgcgc ccggttctac      300

agctacgcct actggggcca gggcaccctg gtgaccgtga gcgccggtgg aggcggttca      360

ggcggaggtg gttctggcgg tggcggatcg gacatcgtga tgacccagac ccccctgagc      420

ctgcccgtga cccccggcga gcccgccagc atcagctgcc ggagcagcca gagcctggtg      480

cacagcaacg gcaacaccta cctgcagtgg tacctgcaga agcccggcca gagcccccag      540

ctgctgatct acaaggtgag caaccggttc agcggcgtgc ccgaccggtt cagcggcagc      600

ggcagcggca ccgacttcac cctgaagatc agccgggtgg aggccgagga cgtgggcgtg      660

tactactgca gccagagcat ctacgtgccc tacaccttcg gccagggcac caagctggag      720

atcaaacgt                                                              729


<210>  3
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  notch

<400>  3
atcctggact acagcttcac aggtggcgct gggcgcgaca ttcccccacc gcagattgag       60

gaggcctgtg agctgcctga gtgccaggtg gatgcaggca ataaggtctg caacctgcag      120

tgtaataatc acgcatgtgg ctgggatggt ggcgactgct ccctcaactt caatgacccc      180

tggaagaact gcacgcagtc tctacagtgc tggaagtatt ttagcgacgg ccactgtgac      240

agccagtgca actcggccgg ctgcctcttt gatggcttcg actgccagct caccgaggga      300

cagtgcaacc ccctgtatga ccagtactgc aaggaccact tcagtgatgg ccactgcgac      360

cagggctgta acagtgccga atgtgagtgg gatggcctag actgtgctga gcatgtaccc      420

gagcggctgg cagccggcac cctggtgctg gtggtgctgc ttccacccga ccagctacgg      480

aacaactcct tccactttct gcgggagctc agccacgtgc tgcacaccaa cgtggtcttc      540

aagcgtgatg cgcaaggcca gcagatgatc ttcccgtact atggccacga ggaagagctg      600

cgcaagcacc caatcaagcg ctctacagtg ggttgggcca cctcttcact gcttcctggt      660

accagtggtg ggcgccagcg cagggagctg gaccccatgg acatccgtgg ctccattgtc      720

tacctggaga tcgacaaccg gcaatgtgtg cagtcatcct cgcagtgctt ccagagtgcc      780

accgatgtgg ctgccttcct aggtgctctt gcgtcacttg gcagcctcaa tattccttac      840

aagattgagg ccgtgaagag tgagccggtg gagcctccgc tgccctcgca gctgcacctc      900

atgtacgtgg cagcggccgc cttcgtgctc ctgttctttg tgggctgtgg ggtgctgctg      960

tcccgcaagc gccggcgg                                                    978


<210>  4
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gal4VP64

<400>  4
atgaagctgc tgagcagcat cgagcaggcc tgtgacatct gccggctgaa gaaactgaag       60

tgcagcaaag aaaagcccaa gtgcgccaag tgcctgaaga acaactggga gtgccggtac      120

agccccaaga ccaagagaag ccccctgacc agagcccacc tgaccgaggt ggaaagccgg      180

ctggaaagac tggaacagct gtttctgctg atcttcccac gcgaggacct ggacatgatc      240

ctgaagatgg acagcctgca ggacatcaag gccctgctga ccggcctgtt cgtgcaggac      300

aacgtgaaca aggacgccgt gaccgacaga ctggccagcg tggaaaccga catgcccctg      360

accctgcggc agcacagaat cagcgccacc agcagcagcg aggaaagcag caacaagggc      420

cagcggcagc tgacagtgtc tgctgctgca ggcggaagcg gaggctctgg cggatctgat      480

gccctggacg acttcgacct ggatatgctg ggcagcgacg ccctggatga ttttgatctg      540

gacatgctgg gatctgacgc tctggacgat ttcgatctcg acatgttggg atcagatgca      600

ctggatgact ttgacctgga catgctcgga tca                                   633


<210>  5
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAL4UAS

<400>  5
tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacgtcggag cactgtcctc       60

cgaacgtcgg agcactgtcc tccgaacgga gcatgtcctc cgaacgtcgg agcactgtcc      120

tccgaacg                                                               128


<210>  6
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minimal CMV

<400>  6
actagttagg cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca       60

gatcgcctgg agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc      120

cagcctctcg acattcgttg gatc                                             144


<210>  7
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL12 P40

<400>  7
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagt                                                    918


<210>  8
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   IL12 P35

<400>  8
agaaacctcc ccgtggccac tccagaccca ggaatgttcc catgccttca ccactcccaa       60

aacctgctga gggccgtcag caacatgctc cagaaggcca gacaaactct agaattttac      120

ccttgcactt ctgaagagat tgatcatgaa gatatcacaa aagataaaac cagcacagtg      180

gaggcctgtt taccattgga attaaccaag aatgagagtt gcctaaattc cagagagacc      240

tctttcataa ctaatgggag ttgcctggcc tccagaaaga cctcttttat gatggccctg      300

tgccttagta gtatttatga agacttgaag atgtaccagg tggagttcaa gaccatgaat      360

gcaaagcttc tgatggatcc taagaggcag atctttctag atcaaaacat gctggcagtt      420

attgatgagc tgatgcaggc cctgaatttc aacagtgaga ctgtgccaca aaaatcctcc      480

cttgaagaac cggattttta taaaactaaa atcaagctct gcatacttct tcatgctttc      540

agaattcggg cagtgactat tgatagagtg atgagctatc tgaatgcttc c               591


<210>  9
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8ź

<400>  9
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  10
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 

<400>  10
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  11
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28Ĥ

<400>  11
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  12
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28

<400>  12
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggccaaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  13
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 ṹ

<400>  13
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgc                             339


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ź

<400>  14
tctcacgcgt caagtggagc                                                   20


<210>  15
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ź

<400>  15
tctgcaccag ctgcacctcg aggtcctctt cagag                                  35


<210>  16
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synNotch-GAL4VP6

<400>  16
atcctggact acagcttcac aggtggcgc                                         29


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synNotch-GAL4VP6

<400>  17
agagccggca gcaggccgcg ggaag                                             25


<210>  18
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGK

<400>  18
gatccttgac ttgcggccgc aactcccacc tgcaacatgc gtgactgact gaggccgcga       60

ctctagagtc gacctgcatc taggcgccgg aattagatct ctcgaggtta acgaattcta      120

ccgggtaggg gaggcgcttt tcccaaggca gtctggagca tgcgctttag cagccccgct      180

gggcacttgg cgctacacaa gtggcctctg gcctcgcaca cattccacat ccaccggtag      240

gcgccaaccg gctccgttct ttggtggccc cttcgcgcca ccttctactc ctcccctagt      300

caggaagttc ccccccgccc cgcagctcgc gtcgtgcagg acgtgacaaa tggaagtagc      360

acgtctcact agtctcgtgc agatggacag caccgctgag caatggaagc gggtaggcct      420

ttggggcagc ggccaatagc agctttgctc cttcgctttc tgggctcaga ggctgggaag      480

gggtgggtcc gggggcgggc tcaggggcgg gctcaggggc ggggcgggcg cccgaaggtc      540

ctccggaggc ccggcattct gcacgcttca aaagcgcacg tctgccgcgc tgttctcctc      600

ttcctcatct ccgggccttt cgacctgcag cccaagctta cc                         642


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mycǩ

<400>  19
gagcaaaaac ttatctctga agaggacctc                                        30


<210>  20
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcherry

<400>  20
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta a               711


<210>  21
<211>  2340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antiGPC3-synNotch-GAL4VP64

<400>  21
gaggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcagc gactacgaga tgcactgggt gcggcaggcc      120

cccggccagg gcctggagtg gatgggcgcc atccaccccg gcagcggcga caccgcctac      180

aaccagcggt tcaagggccg ggtgaccatc accgccgaca agagcaccag caccgcctac      240

atggagctga gcagcctgcg gagcgaggac accgccgtgt actactgcgc ccggttctac      300

agctacgcct actggggcca gggcaccctg gtgaccgtga gcgccggtgg aggcggttca      360

ggcggaggtg gttctggcgg tggcggatcg gacatcgtga tgacccagac ccccctgagc      420

ctgcccgtga cccccggcga gcccgccagc atcagctgcc ggagcagcca gagcctggtg      480

cacagcaacg gcaacaccta cctgcagtgg tacctgcaga agcccggcca gagcccccag      540

ctgctgatct acaaggtgag caaccggttc agcggcgtgc ccgaccggtt cagcggcagc      600

ggcagcggca ccgacttcac cctgaagatc agccgggtgg aggccgagga cgtgggcgtg      660

tactactgca gccagagcat ctacgtgccc tacaccttcg gccagggcac caagctggag      720

atcaaacgta tcctggacta cagcttcaca ggtggcgctg ggcgcgacat tcccccaccg      780

cagattgagg aggcctgtga gctgcctgag tgccaggtgg atgcaggcaa taaggtctgc      840

aacctgcagt gtaataatca cgcatgtggc tgggatggtg gcgactgctc cctcaacttc      900

aatgacccct ggaagaactg cacgcagtct ctacagtgct ggaagtattt tagcgacggc      960

cactgtgaca gccagtgcaa ctcggccggc tgcctctttg atggcttcga ctgccagctc     1020

accgagggac agtgcaaccc cctgtatgac cagtactgca aggaccactt cagtgatggc     1080

cactgcgacc agggctgtaa cagtgccgaa tgtgagtggg atggcctaga ctgtgctgag     1140

catgtacccg agcggctggc agccggcacc ctggtgctgg tggtgctgct tccacccgac     1200

cagctacgga acaactcctt ccactttctg cgggagctca gccacgtgct gcacaccaac     1260

gtggtcttca agcgtgatgc gcaaggccag cagatgatct tcccgtacta tggccacgag     1320

gaagagctgc gcaagcaccc aatcaagcgc tctacagtgg gttgggccac ctcttcactg     1380

cttcctggta ccagtggtgg gcgccagcgc agggagctgg accccatgga catccgtggc     1440

tccattgtct acctggagat cgacaaccgg caatgtgtgc agtcatcctc gcagtgcttc     1500

cagagtgcca ccgatgtggc tgccttccta ggtgctcttg cgtcacttgg cagcctcaat     1560

attccttaca agattgaggc cgtgaagagt gagccggtgg agcctccgct gccctcgcag     1620

ctgcacctca tgtacgtggc agcggccgcc ttcgtgctcc tgttctttgt gggctgtggg     1680

gtgctgctgt cccgcaagcg ccggcggatg aagctgctga gcagcatcga gcaggcctgt     1740

gacatctgcc ggctgaagaa actgaagtgc agcaaagaaa agcccaagtg cgccaagtgc     1800

ctgaagaaca actgggagtg ccggtacagc cccaagacca agagaagccc cctgaccaga     1860

gcccacctga ccgaggtgga aagccggctg gaaagactgg aacagctgtt tctgctgatc     1920

ttcccacgcg aggacctgga catgatcctg aagatggaca gcctgcagga catcaaggcc     1980

ctgctgaccg gcctgttcgt gcaggacaac gtgaacaagg acgccgtgac cgacagactg     2040

gccagcgtgg aaaccgacat gcccctgacc ctgcggcagc acagaatcag cgccaccagc     2100

agcagcgagg aaagcagcaa caagggccag cggcagctga cagtgtctgc tgctgcaggc     2160

ggaagcggag gctctggcgg atctgatgcc ctggacgact tcgacctgga tatgctgggc     2220

agcgacgccc tggatgattt tgatctggac atgctgggat ctgacgctct ggacgatttc     2280

gatctcgaca tgttgggatc agatgcactg gatgactttg acctggacat gctcggatca     2340


<210>  22
<211>  3251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHR-GAL4UAS-IL12-PGK-mcherry

<400>  22
tcggagcact gtcctccgaa cgtcggagca ctgtcctccg aacgtcggag cactgtcctc       60

cgaacgtcgg agcactgtcc tccgaacgga gcatgtcctc cgaacgtcgg agcactgtcc      120

tccgaacgac tagttaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg      180

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg      240

gaccgatcca gcctctcgac attcgttgga tcatgtgtca ccagcagttg gtcatctctt      300

ggttttccct ggtttttctg gcatctcccc tcgtggccat atgggaactg aagaaagatg      360

tttatgtcgt agaattggat tggtatccgg atgcccctgg agaaatggtg gtcctcacct      420

gtgacacccc tgaagaagat ggtatcacct ggaccttgga ccagagcagt gaggtcttag      480

gctctggcaa aaccctgacc atccaagtca aagagtttgg agatgctggc cagtacacct      540

gtcacaaagg aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa aaggaagatg      600

gaatttggtc cactgatatt ttaaaggacc agaaagaacc caaaaataag acctttctaa      660

gatgcgaggc caagaattat tctggacgtt tcacctgctg gtggctgacg acaatcagta      720

ctgatttgac attcagtgtc aaaagcagca gaggctcttc tgacccccaa ggggtgacgt      780

gcggagctgc tacactctct gcagagagag tcagagggga caacaaggag tatgagtact      840

cagtggagtg ccaggaggac agtgcctgcc cagctgctga ggagagtctg cccattgagg      900

tcatggtgga tgccgttcac aagctcaagt atgaaaacta caccagcagc ttcttcatca      960

gggacatcat caaacctgac ccacccaaga acttgcagct gaagccatta aagaattctc     1020

ggcaggtgga ggtcagctgg gagtaccctg acacctggag tactccacat tcctacttct     1080

ccctgacatt ctgcgttcag gtccagggca agagcaagag agaaaagaaa gatagagtct     1140

tcacggacaa gacctcagcc acggtcatct gccgcaaaaa tgccagcatt agcgtgcggg     1200

cccaggaccg ctactatagc tcatcttgga gcgaatgggc atctgtgccc tgcagtggtg     1260

gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tagaaacctc cccgtggcca     1320

ctccagaccc aggaatgttc ccatgccttc accactccca aaacctgctg agggccgtca     1380

gcaacatgct ccagaaggcc agacaaactc tagaatttta cccttgcact tctgaagaga     1440

ttgatcatga agatatcaca aaagataaaa ccagcacagt ggaggcctgt ttaccattgg     1500

aattaaccaa gaatgagagt tgcctaaatt ccagagagac ctctttcata actaatggga     1560

gttgcctggc ctccagaaag acctctttta tgatggccct gtgccttagt agtatttatg     1620

aagacttgaa gatgtaccag gtggagttca agaccatgaa tgcaaagctt ctgatggatc     1680

ctaagaggca gatctttcta gatcaaaaca tgctggcagt tattgatgag ctgatgcagg     1740

ccctgaattt caacagtgag actgtgccac aaaaatcctc ccttgaagaa ccggattttt     1800

ataaaactaa aatcaagctc tgcatacttc ttcatgcttt cagaattcgg gcagtgacta     1860

ttgatagagt gatgagctat ctgaatgctt cctaaacgcg tgatccttga cttgcggccg     1920

caactcccac ctgcaacatg cgtgactgac tgaggccgcg actctagagt cgacctgcat     1980

ctaggcgccg gaattagatc tctcgaggtt aacgaattct accgggtagg ggaggcgctt     2040

ttcccaaggc agtctggagc atgcgcttta gcagccccgc tgggcacttg gcgctacaca     2100

agtggcctct ggcctcgcac acattccaca tccaccggta ggcgccaacc ggctccgttc     2160

tttggtggcc ccttcgcgcc accttctact cctcccctag tcaggaagtt cccccccgcc     2220

ccgcagctcg cgtcgtgcag gacgtgacaa atggaagtag cacgtctcac tagtctcgtg     2280

cagatggaca gcaccgctga gcaatggaag cgggtaggcc tttggggcag cggccaatag     2340

cagctttgct ccttcgcttt ctgggctcag aggctgggaa ggggtgggtc cgggggcggg     2400

ctcaggggcg ggctcagggg cggggcgggc gcccgaaggt cctccggagg cccggcattc     2460

tgcacgcttc aaaagcgcac gtctgccgcg ctgttctcct cttcctcatc tccgggcctt     2520

tcgacctgca gcccaagctt accatggtga gcaagggcga ggaggataac atggccatca     2580

tcaaggagtt catgcgcttc aaggtgcaca tggagggctc cgtgaacggc cacgagttcg     2640

agatcgaggg cgagggcgag ggccgcccct acgagggcac ccagaccgcc aagctgaagg     2700

tgaccaaggg tggccccctg cccttcgcct gggacatcct gtcccctcag ttcatgtacg     2760

gctccaaggc ctacgtgaag caccccgccg acatccccga ctacttgaag ctgtccttcc     2820

ccgagggctt caagtgggag cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga     2880

cccaggactc ctccctgcag gacggcgagt tcatctacaa ggtgaagctg cgcggcacca     2940

acttcccctc cgacggcccc gtaatgcaga agaagaccat gggctgggag gcctcctccg     3000

agcggatgta ccccgaggac ggcgccctga agggcgagat caagcagagg ctgaagctga     3060

aggacggcgg ccactacgac gctgaggtca agaccaccta caaggccaag aagcccgtgc     3120

agctgcccgg cgcctacaac gtcaacatca agttggacat cacctcccac aacgaggact     3180

acaccatcgt ggaacagtac gaacgcgccg agggccgcca ctccaccggc ggcatggacg     3240

agctgtacaa g                                                          3251


<210>  23
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC-28Z

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Gln Ser Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg 
465                 


<210>  24
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC-BBZ

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Gln Ser Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    290                 295                 300                 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
305                 310                 315                 320 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                325                 330                 335     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            340                 345                 350         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 


Pro Arg 
465     


<210>  25
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC-28BBZ

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Gln Ser Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510     


<210>  26
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3-z

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile His Pro Gly Ser Gly Asp Thr Ala Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Tyr Ser Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Gln Ser Ile Tyr Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                245                 250                 255     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            260                 265                 270         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        275                 280                 285             


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    290                 295                 300                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
305                 310                 315                 320 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                325                 330                 335     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            340                 345                 350         


Leu Pro Pro Arg 
        355     


<210>  27
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL12İ

<400>  27

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535                 540 


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAL4UAS

<400>  28
agatcgcgat gggaaaaaat tc                                                22


<210>  29
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAL4UAS

<400>  29
tgctgaactt cactctcatg atccaacgaa tgtcgag                                37


