                         SEQUENCE LISTING

<110>  Fred Hutchinson
       Dudakov, Jarrod
       Kinsella, Sinead
 
<120>  COMPOSITIONS AND METHODS TO PROMOTE THYMIC REGENERATION

<130>  F053-0079PCT

<150>  US62/616,252
<151>  2018-01-11

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1040
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Glu Glu Gly Gly Ser Ala Ser His Asp Glu Glu Glu Arg Ala 
1               5                   10                  15      


Ser Val Leu Leu Gly His Ser Pro Gly Cys Glu Met Cys Ser Gln Glu 
            20                  25                  30          


Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu Leu Leu Val Ser Gly 
        35                  40                  45              


Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp Leu Leu Ser Trp Glu 
    50                  55                  60                  


Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His Leu Leu Gly Gln Pro 
65                  70                  75                  80  


Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr Val Trp Asn Lys Gly 
                85                  90                  95      


Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala Gln Glu Ala Gln Ala 
            100                 105                 110         


Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp Asp Pro His Ser Leu 
        115                 120                 125             


His Pro Ala Arg Asp Leu Gln Ser His Arg Pro Ala Ile Val Arg Arg 
    130                 135                 140                 


Leu His Ser His Val Glu Asn Met Leu Asp Leu Ala Trp Glu Arg Gly 
145                 150                 155                 160 


Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg Leu Pro Ile Phe Thr 
                165                 170                 175     


Pro Ser Gln Arg Ala Arg Arg Leu Leu Asp Leu Ala Thr Val Lys Ala 
            180                 185                 190         


Asn Gly Leu Ala Ala Phe Leu Leu Gln His Val Gln Glu Leu Pro Val 
        195                 200                 205             


Pro Leu Ala Leu Pro Leu Glu Ala Ala Thr Cys Lys Lys Tyr Met Ala 
    210                 215                 220                 


Lys Leu Arg Thr Thr Val Ser Ala Gln Ser Arg Phe Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Gly Ala Glu Thr Leu Cys Leu Glu Asp Ile Tyr Thr Glu Asn Val 
                245                 250                 255     


Leu Glu Val Trp Ala Asp Val Gly Met Ala Gly Pro Pro Gln Lys Ser 
            260                 265                 270         


Pro Ala Thr Leu Gly Leu Glu Glu Leu Phe Ser Thr Pro Gly His Leu 
        275                 280                 285             


Asn Asp Asp Ala Asp Thr Val Leu Val Val Gly Glu Ala Gly Ser Gly 
    290                 295                 300                 


Lys Ser Thr Leu Leu Gln Arg Leu His Leu Leu Trp Ala Ala Gly Gln 
305                 310                 315                 320 


Asp Phe Gln Glu Phe Leu Phe Val Phe Pro Phe Ser Cys Arg Gln Leu 
                325                 330                 335     


Gln Cys Met Ala Lys Pro Leu Ser Val Arg Thr Leu Leu Phe Glu His 
            340                 345                 350         


Cys Cys Trp Pro Asp Val Gly Gln Glu Asp Ile Phe Gln Leu Leu Leu 
        355                 360                 365             


Asp His Pro Asp Arg Val Leu Leu Thr Phe Asp Gly Phe Asp Glu Phe 
    370                 375                 380                 


Lys Phe Arg Phe Thr Asp Arg Glu Arg His Cys Ser Pro Thr Asp Pro 
385                 390                 395                 400 


Thr Ser Val Gln Thr Leu Leu Phe Asn Leu Leu Gln Gly Asn Leu Leu 
                405                 410                 415     


Lys Asn Ala Arg Lys Val Val Thr Ser Arg Pro Ala Ala Val Ser Ala 
            420                 425                 430         


Phe Leu Arg Lys Tyr Ile Arg Thr Glu Phe Asn Leu Lys Gly Phe Ser 
        435                 440                 445             


Glu Gln Gly Ile Glu Leu Tyr Leu Arg Lys Arg His His Glu Pro Gly 
    450                 455                 460                 


Val Ala Asp Arg Leu Ile Arg Leu Leu Gln Glu Thr Ser Ala Leu His 
465                 470                 475                 480 


Gly Leu Cys His Leu Pro Val Phe Ser Trp Met Val Ser Lys Cys His 
                485                 490                 495     


Gln Glu Leu Leu Leu Gln Glu Gly Gly Ser Pro Lys Thr Thr Thr Asp 
            500                 505                 510         


Met Tyr Leu Leu Ile Leu Gln His Phe Leu Leu His Ala Thr Pro Pro 
        515                 520                 525             


Asp Ser Ala Ser Gln Gly Leu Gly Pro Ser Leu Leu Arg Gly Arg Leu 
    530                 535                 540                 


Pro Thr Leu Leu His Leu Gly Arg Leu Ala Leu Trp Gly Leu Gly Met 
545                 550                 555                 560 


Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val Ser 
                565                 570                 575     


Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val Val 
            580                 585                 590         


Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln Cys 
        595                 600                 605             


Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro Ala 
    610                 615                 620                 


Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro Met 
625                 630                 635                 640 


Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys Asp 
                645                 650                 655     


Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu Gln 
            660                 665                 670         


Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp Gly 
        675                 680                 685             


Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg Gln 
    690                 695                 700                 


Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe His 
705                 710                 715                 720 


Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala Met 
                725                 730                 735     


Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu Glu 
            740                 745                 750         


Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu Lys 
        755                 760                 765             


Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala Phe 
    770                 775                 780                 


Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr Asn 
785                 790                 795                 800 


Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly Val 
                805                 810                 815     


Cys Lys Ala Leu Tyr Leu Arg Asp Asn Asn Ile Ser Asp Arg Gly Ile 
            820                 825                 830         


Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu Gln Lys Leu 
        835                 840                 845             


Ala Leu Phe Asn Asn Lys Leu Thr Asp Gly Cys Ala His Ser Met Ala 
    850                 855                 860                 


Lys Leu Leu Ala Cys Arg Gln Asn Phe Leu Ala Leu Arg Leu Gly Asn 
865                 870                 875                 880 


Asn Tyr Ile Thr Ala Ala Gly Ala Gln Val Leu Ala Glu Gly Leu Arg 
                885                 890                 895     


Gly Asn Thr Ser Leu Gln Phe Leu Gly Phe Trp Gly Asn Arg Val Gly 
            900                 905                 910         


Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu Gly Asp His Gln Ser 
        915                 920                 925             


Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile Gly Ser Val Gly Ala 
    930                 935                 940                 


Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val Met Leu Glu Glu Leu 
945                 950                 955                 960 


Cys Leu Glu Glu Asn His Leu Gln Asp Glu Gly Val Cys Ser Leu Ala 
                965                 970                 975     


Glu Gly Leu Lys Lys Asn Ser Ser Leu Lys Ile Leu Lys Leu Ser Asn 
            980                 985                 990         


Asn Cys Ile Thr Tyr Leu Gly Ala  Glu Ala Leu Leu Gln  Ala Leu Glu 
        995                 1000                 1005             


Arg Asn  Asp Thr Ile Leu Glu  Val Trp Leu Arg Gly  Asn Thr Phe 
    1010                 1015                 1020             


Ser Leu  Glu Glu Val Asp Lys  Leu Gly Cys Arg Asp  Thr Arg Leu 
    1025                 1030                 1035             


Leu Leu  
    1040 


<210>  2
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210>  3
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu 
            180                 185                 190 


<210>  4
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  5
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210>  6
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  7
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Met Val Val Leu Leu Cys Gln Val Leu Leu Gly Gly Ala Ser 
1               5                   10                  15      


His Ala Ser Leu Ile Pro Glu Thr Gly Lys Lys Lys Val Ala Glu Ile 
            20                  25                  30          


Gln Gly His Ala Gly Gly Arg Arg Ser Gly Gln Ser His Glu Leu Leu 
        35                  40                  45              


Arg Asp Phe Glu Ala Thr Leu Leu Gln Met Phe Gly Leu Arg Arg Arg 
    50                  55                  60                  


Pro Gln Pro Ser Lys Ser Ala Val Ile Pro Asp Tyr Met Arg Asp Leu 
65                  70                  75                  80  


Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu Glu Gln Ile His Ser Thr 
                85                  90                  95      


Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser Arg Ala Asn Thr Val Arg 
            100                 105                 110         


Ser Phe His His Glu Glu His Leu Glu Asn Ile Pro Gly Thr Ser Glu 
        115                 120                 125             


Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu Ser Ser Ile Pro Glu Asn 
    130                 135                 140                 


Glu Val Ile Ser Ser Ala Glu Leu Arg Leu Phe Arg Glu Gln Val Asp 
145                 150                 155                 160 


Gln Gly Pro Asp Trp Glu Arg Gly Phe His Arg Ile Asn Ile Tyr Glu 
                165                 170                 175     


Val Met Lys Pro Pro Ala Glu Val Val Pro Gly His Leu Ile Thr Arg 
            180                 185                 190         


Leu Leu Asp Thr Arg Leu Val His His Asn Val Thr Arg Trp Glu Thr 
        195                 200                 205             


Phe Asp Val Ser Pro Ala Val Leu Arg Trp Thr Arg Glu Lys Gln Pro 
    210                 215                 220                 


Asn Tyr Gly Leu Ala Ile Glu Val Thr His Leu His Gln Thr Arg Thr 
225                 230                 235                 240 


His Gln Gly Gln His Val Arg Ile Ser Arg Ser Leu Pro Gln Gly Ser 
                245                 250                 255     


Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu Val Thr Phe Gly His Asp 
            260                 265                 270         


Gly Arg Gly His Ala Leu Thr Arg Arg Arg Arg Ala Lys Arg Ser Pro 
        275                 280                 285             


Lys His His Ser Gln Arg Ala Arg Lys Lys Asn Lys Asn Cys Arg Arg 
    290                 295                 300                 


His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
305                 310                 315                 320 


Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr Cys His Gly Asp Cys Pro 
                325                 330                 335     


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
            340                 345                 350         


Thr Leu Val Asn Ser Val Asn Ser Ser Ile Pro Lys Ala Cys Cys Val 
        355                 360                 365             


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Tyr Asp 
    370                 375                 380                 


Lys Val Val Leu Lys Asn Tyr Gln Glu Met Val Val Glu Gly Cys Gly 
385                 390                 395                 400 


Cys Arg 
        


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rac1 Inhibitor W56

<400>  8

Met Val Asp Gly Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly 
1               5                   10                  15      


<210>  9
<211>  22
<212>  RNA
<213>  Mus musculus

<400>  9
uagcaccauu ugaaaucggu ua                                                22


<210>  10
<211>  22
<212>  RNA
<213>  Mus musculus

<400>  10
ugaccgauuu cuccuggugu uc                                                22


<210>  11
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  11
uagcaccauu ugaaaucggu                                                   20


<210>  12
<211>  88
<212>  RNA
<213>  Mus musculus

<400>  12
aucucuuaca caggcugacc gauuucuccu gguguucaga gucuguuuuu gucuagcacc       60

auuugaaauc gguuaugaug uaggggga                                          88


