                         SEQUENCE LISTING

<110>  KEROS THERAPEUTICS, INC.
 
<120>  ACTIVIN RECEPTOR TYPE IIB VARIANTS AND METHODS OF USE THEREOF

<130>  51184-007WO3

<150>  62/702,747
<151>  2018-07-24

<150>  62/616,991
<151>  2018-01-12

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ile or Leu

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Leu or Lys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leu or Val

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Pro or Arg

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Tyr or Glu

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa is Arg or Leu

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Xaa is Ser or Ile

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa is Ile or Leu

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa is Ile or Leu

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Xaa is Phe or Ile

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is Gln, Thr, or Asp

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa is Glu, Asp, or Thr

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is Lys or Thr

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa is Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa is Phe or Met

<400>  1

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Xaa Xaa Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Xaa Xaa Arg Thr Asn Gln Xaa Gly Xaa Glu Xaa Cys Xaa Gly 
            20                  25                  30          


Xaa Xaa Asp Lys Arg Xaa His Cys Xaa Ala Ser Trp Xaa Asn Xaa Xaa 
        35                  40                  45              


Gly Xaa Xaa Glu Xaa Val Lys Xaa Gly Cys Trp Leu Asp Asp Xaa Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Xaa Xaa Cys Val Ala Xaa Xaa Xaa Xaa Pro Xaa Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Xaa Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  2
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Phe Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Lys Asp Arg Thr Asn Gln Ser Gly Leu Glu Pro Cys Tyr Gly 
            20                  25                  30          


Asp Gln Asp Lys Arg Arg His Cys Phe Ala Ser Trp Lys Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Asp Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  4
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  5
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ile Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  6
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ile Thr 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  7
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Pro Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  8
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly 
            20                  25                  30          


Asp Lys Asp Lys Arg Leu His Cys Phe Ala Ser Trp Lys Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  9
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Phe Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Lys Asp Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly 
            20                  25                  30          


Asp Gln Asp Lys Arg Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  11
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Lys Lys Asp Ser Pro Glu Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  12
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Leu Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Val Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Lys Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Ser Leu Glu Ile Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Thr Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  13
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Leu Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Val Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Lys Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Ser Leu Glu Ile Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Asp Thr Cys Val Ala Thr Glu Glu Asn Pro Gln Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  14
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Leu Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Val Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Lys Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Ser Leu Glu Ile Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Thr Asp Cys Val Ala Thr Lys Glu Asn Pro Gln Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  15
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Leu Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Val Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Lys Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Ser Leu Glu Ile Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Asp Thr Cys Val Ala Thr Lys Glu Asn Pro Gln Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  16
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn 
1               5                   10                  15      


Ala Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys 
            20                  25                  30          


Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn 
        35                  40                  45              


Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp 
    50                  55                  60                  


Ile Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro 
65                  70                  75                  80  


Glu Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe 
                85                  90                  95      


Ser Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser 
            100                 105                 


<210>  17
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn 
1               5                   10                  15      


Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly 
            20                  25                  30          


Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser 
        35                  40                  45              


Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn 
    50                  55                  60                  


Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val 
65                  70                  75                  80  


Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His 
                85                  90                  95      


Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr 
            100                 105                 110         


Ala Pro Thr 
        115 


<210>  18
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  19
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  19

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Gly Gly Gly Ala 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Gly Gly Gly Ser 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Gly Gly Gly Gly 
1               


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Gly Gly Gly Gly Ala 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Gly Gly Gly Gly Ser 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Gly Gly Gly Gly Gly 
1               5   


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gly Gly Ala Gly 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Gly Gly Ser Gly 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Ala Gly Gly Gly 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Ser Gly Gly Gly 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Gly Ala Gly Ala 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Gly Ser Gly Ser 
1               


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Gly Ala Gly Ala Gly Ala 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Gly Ala Gly Ala Gly Ala Gly Ala 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Gly Gly Ala Gly Gly Ala 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Gly Gly Ala Gly Gly Ala Gly Gly Ala 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gly Gly Ala Gly Gly Gly Ala Gly 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gly Gly Gly Ala Gly 
1               5   


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Gly Gly Gly Ala Gly Gly 
1               5       


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gly Gly Gly Ala Gly Gly Gly 
1               5           


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Ala Ala Ala Leu 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Ala Ala Ala Lys 
1               


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Ala Ala Ala Arg 
1               


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  61
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Gly Glu Asn Leu Tyr Phe Gln Ser Gly Gly 
1               5                   10  


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Ser Ala Cys Tyr Cys Glu Leu Ser 
1               5               


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Arg Ser Ile Ala Thr 
1               5   


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Arg Pro Ala Cys Lys Ile Pro Asn Asp Leu Lys Gln Lys Val Met Asn 
1               5                   10                  15      


His 
    


<210>  66
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Gly Gly Ser Ala Gly Gly Ser Gly Ser Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Ala Ser Gly Thr Gly Thr Ala Gly Gly Thr Gly Ser Gly Ser Gly 
            20                  25                  30          


Thr Gly Ser Gly 
        35      


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Ala Ala Ala Asn Ser Ser Ile Asp Leu Ile Ser Val Pro Val Asp Ser 
1               5                   10                  15      


Arg 
    


<210>  68
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
1               5                   10                  15      


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Glu Ala Ala Ala Lys 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Pro Ala Pro Ala Pro 
1               5   


<210>  71
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  73
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn Ser 
1               5                   10                  15      


His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys Tyr 
            20                  25                  30          


Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu Ala 
        35                  40                  45              


Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly His 
65                  70                  75                  80  


Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr 
                85                  90              


<210>  74
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


