                         SEQUENCE LISTING

<110>  Translate Bio MA, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR FACILITATING DELIVERY OF SYNTHETIC 
       NUCLEIC ACIDS TO CELLS

<130>  R0693.70046WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/615,577
<151>  2018-01-10

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
ccattgtcac actcc                                                        15


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gly Arg Lys Lys Lys Arg Arg Gln Arg Arg Arg Tyr Lys 
1               5                   10              


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Arg Xaa Arg Xaa Asx 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Arg Phe Arg Arg Phe Arg Arg Phe Arg Arg Phe Arg Xaa Asx 
1               5                   10                  


<210>  7
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
cgatcattca aa                                                           12


<210>  8
<211>  1363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
gccgccgcga tcgcatgctg agcaacctga ggatcctgct gaacaacgcc gccctgagga       60

agggccacac cagcgtggtg aggcacttct ggtgcggcaa gcccgtgcag agccaggtgc      120

agctgaaggg ccgtgacctt ctcactctaa aaaactttac cggagaagaa attaaatata      180

tgctatggct atcagcagat ctgaaattta ggataaaaca gaaaggagag tatttgcctt      240

tattgcaagg gaagtcctta ggcatgattt ttgagaaaag aagtactcga acaagattgt      300

ctacagaaac aggctttgca cttctgggag gacatccttg ttttcttacc acacaagata      360

ttcatttggg tgtgaatgaa agtctcacgg acacggcccg tgtattgtct agcatggcag      420

atgcagtatt ggctcgagtg tataaacaat cagatttgga cacccttgct aaagaagcat      480

ccatcccaat tatcaatggg ctgtcagatt tgtaccatcc tatccagatc ctggctgatt      540

acctcacgct ccaggaacac tatagctctc tgaaaggtct taccctcagc tggatcgggg      600

atgggaacaa tatcctgcac tccatcatga tgagcgcagc gaaattcgga atgcaccttc      660

aggcagctac tccaaagggt tatgagccgg atgctagtgt aaccaagttg gcagagcagt      720

atgccaaaga gaatggtacc aagctgttgc tgacaaatga tccattggaa gcagcgcatg      780

gaggcaatgt attaattaca gacacttgga taagcatggg acaagaagag gagaagaaaa      840

agcggctcca ggctttccaa ggttaccagg ttacaatgaa gactgctaaa gttgctgcct      900

ctgactggac atttttacac tgcttgccca gaaagccaga agaagtggat gatgaagtct      960

tttattctcc tcgatcacta gtgttcccag aggcagaaaa cagaaagtgg acaatcatgg     1020

ctgtcatggt gtccctgctg acagattact cacctcagct ccagaagcct aaatttgagc     1080

agaaactcat ctcagaagag gatctggatt acaaggatga cgacgataag taatgttgtg     1140

ttacttgtca agaaagaagc aatgttcttc agtaacagaa tgagttggtt tatggggaaa     1200

agagaagaga atctaaaaaa taaacaaatc cctaacacgt ggtaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                       1363


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  cytosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  guanosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  cytosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine LNA

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl adenosine nucleotide

<400>  9
cattgcttct ttcttgacaa                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  guanosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2?-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl guanosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl adenosine nucleotide

<400>  10
catugctucu tucutgacaa                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl adenosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  cytosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  adenosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  adenosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  guanosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  adenosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl uracil nucleotide

<400>  11
aaccaactca ttctgttacu                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl adenosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl adenosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl adenosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  guanosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl adenosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl uracil nucleotide

<400>  12
aaccaacuca tucugutacu                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  guanosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  cytosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  cytosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl uracil nucleotide

<400>  13
uattttttag attctcttcu                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl uracil nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl guanosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl cytosine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl thymidine nucleotide w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl uracil nucleotide

<400>  14
uatututuag autctctucu                                                   20


<210>  15
<211>  1493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
gccgccgcga tcgcatgctg agcaacctga ggatcctgct gaacaacgcc gccctgagga       60

agggccacac cagcgtggtg aggcacttct ggtgcggcaa gcccgtgcag agccaggtgc      120

agctgaaggg ccgtgacctt ctcactctaa aaaactttac cggagaagaa attaaatata      180

tgctatggct atcagcagat ctgaaattta ggataaaaca gaaaggagag tatttgcctt      240

tattgcaagg gaagtcctta ggcatgattt ttgagaaaag aagtactcga acaagattgt      300

ctacagaaac aggctttgca cttctgggag gacatccttg ttttcttacc acacaagata      360

ttcatttggg tgtgaatgaa agtctcacgg acacggcccg tgtattgtct agcatggcag      420

atgcagtatt ggctcgagtg tataaacaat cagatttgga cacccttgct aaagaagcat      480

ccatcccaat tatcaatggg ctgtcagatt tgtaccatcc tatccagatc ctggctgatt      540

acctcacgct ccaggaacac tatagctctc tgaaaggtct taccctcagc tggatcgggg      600

atgggaacaa tatcctgcac tccatcatga tgagcgcagc gaaattcgga atgcaccttc      660

aggcagctac tccaaagggt tatgagccgg atgctagtgt aaccaagttg gcagagcagt      720

atgccaaaga gaatggtacc aagctgttgc tgacaaatga tccattggaa gcagcgcatg      780

gaggcaatgt attaattaca gacacttgga taagcatggg acaagaagag gagaagaaaa      840

agcggctcca ggctttccaa ggttaccagg ttacaatgaa gactgctaaa gttgctgcct      900

ctgactggac atttttacac tgcttgccca gaaagccaga agaagtggat gatgaagtct      960

tttattctcc tcgatcacta gtgttcccag aggcagaaaa cagaaagtgg acaatcatgg     1020

ctgtcatggt gtccctgctg acagattact cacctcagct ccagaagcct aaatttgagc     1080

agaaactcat ctcagaagag gatctggatt acaaggatga cgacgataag taagctgcct     1140

tctgcggggc ttgccttctg gccatgccct tcttctctcc cttgcacctg tacctcttgg     1200

tctttgaata aagcctgagt aggaagatta cgttgcacgg agtgtgacaa tggattacgt     1260

tgcacggagt gtgacaatgg attacgttgc acggagtgtg acaatggatt acgttgcacg     1320

gagtgtgaca atggattacg ttgcacggag tgtgacaatg gattacgttg cacaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1493


<210>  16
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  cytosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  adenosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  guanosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  thymidine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  cytosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  adenosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  adenosine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  thymidine DNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl cytosine LNA w/3' phosphorothioate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl cytosine LNA

<400>  16
ccattgtcac actcc                                                        15


<210>  17
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(40)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (56)..(58)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (74)..(76)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (92)..(94)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (110)..(112)
<223>  n is a, c, g, or t

<400>  17
taatacgact cactataggn nnggagtgtg acaatggnnn ggagtgtgac aatggnnngg       60

agtgtgacaa tggnnnggag tgtgacaatg gnnnggagtg tgacaatggn nn              112


<210>  18
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (37)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (55)..(57)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (73)..(75)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (91)..(93)
<223>  n is a, c, g, or t

<400>  18
nnnccattgt cacactccnn nccattgtca cactccnnnc cattgtcaca ctccnnncca       60

ttgtcacact ccnnnccatt gtcacactcc nnncctatag tgagtcgtat ta              112


<210>  19
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
tgttgtgtta cttgtcaaga aagaagcaat gttcttcagt aacagaatga gttggtttat       60

ggggaaaaga gaagagaatc taaaaaataa acaaatccct aacacgtggt                 110


<210>  20
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
accacgtgtt agggatttgt ttatttttta gattctcttc tcttttcccc ataaaccaac       60

tcattctgtt actgaagaac attgcttctt tcttgacaag taacacaaca                 110


<210>  21
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
attacgttgc acccattgtc acactccatt acgtgcaccc attgtcacac tccattacgt       60

tgcacccatt gtcacactcc attacgttgc acccattgtc acactccatt acgttgcacc      120

cattgtcaca ctccattacg ttgcac                                           146


<210>  22
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
gtgcaacgta atggagtgtg acaatgggtg caacgtaatg gagtgtgaca atgggtgcaa       60

cgtaatggag tgtgacaatg ggtgcaacgt aatggagtgt gacaatgggt gcaacgtaat      120

ggagtgtgac aatgggtgca acgtaat                                          147


