                         SEQUENCE LISTING

<110>  Lygos, Inc.
 
<120>  Recombinant Host Cells and Methods for the Production of 
       Isobutyric Acid

<130>  LYGOS-0011-01-WO

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  570
<212>  PRT
<213>  Bacillus subtilis

<400>  1

Met Thr Lys Ala Thr Lys Glu Gln Lys Ser Leu Val Lys Asn Arg Gly 
1               5                   10                  15      


Ala Glu Leu Val Val Asp Cys Leu Val Glu Gln Gly Val Thr His Val 
            20                  25                  30          


Phe Gly Ile Pro Gly Ala Lys Ile Asp Ala Val Phe Asp Ala Leu Gln 
        35                  40                  45              


Asp Lys Gly Pro Glu Ile Ile Val Ala Arg His Glu Gln Asn Ala Ala 
    50                  55                  60                  


Phe Met Ala Gln Ala Val Gly Arg Leu Thr Gly Lys Pro Gly Val Val 
65                  70                  75                  80  


Leu Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly Leu Leu 
                85                  90                  95      


Thr Ala Asn Thr Glu Gly Asp Pro Val Val Ala Leu Ala Gly Asn Val 
            100                 105                 110         


Ile Arg Ala Asp Arg Leu Lys Arg Thr His Gln Ser Leu Asp Asn Ala 
        115                 120                 125             


Ala Leu Phe Gln Pro Ile Thr Lys Tyr Ser Val Glu Val Gln Asp Val 
    130                 135                 140                 


Lys Asn Ile Pro Glu Ala Val Thr Asn Ala Phe Arg Ile Ala Ser Ala 
145                 150                 155                 160 


Gly Gln Ala Gly Ala Ala Phe Val Ser Phe Pro Gln Asp Val Val Asn 
                165                 170                 175     


Glu Val Thr Asn Thr Lys Asn Val Arg Ala Val Ala Ala Pro Lys Leu 
            180                 185                 190         


Gly Pro Ala Ala Asp Asp Ala Ile Ser Ala Ala Ile Ala Lys Ile Gln 
        195                 200                 205             


Thr Ala Lys Leu Pro Val Val Leu Val Gly Met Lys Gly Gly Arg Pro 
    210                 215                 220                 


Glu Ala Ile Lys Ala Val Arg Lys Leu Leu Lys Lys Val Gln Leu Pro 
225                 230                 235                 240 


Phe Val Glu Thr Tyr Gln Ala Ala Gly Thr Leu Ser Arg Asp Leu Glu 
                245                 250                 255     


Asp Gln Tyr Phe Gly Arg Ile Gly Leu Phe Arg Asn Gln Pro Gly Asp 
            260                 265                 270         


Leu Leu Leu Glu Gln Ala Asp Val Val Leu Thr Ile Gly Tyr Asp Pro 
        275                 280                 285             


Ile Glu Tyr Asp Pro Lys Phe Trp Asn Ile Asn Gly Asp Arg Thr Ile 
    290                 295                 300                 


Ile His Leu Asp Glu Ile Ile Ala Asp Ile Asp His Ala Tyr Gln Pro 
305                 310                 315                 320 


Asp Leu Glu Leu Ile Gly Asp Ile Pro Ser Thr Ile Asn His Ile Glu 
                325                 330                 335     


His Asp Ala Val Lys Val Glu Phe Ala Glu Arg Glu Gln Lys Ile Leu 
            340                 345                 350         


Ser Asp Leu Lys Gln Tyr Met His Glu Gly Glu Gln Val Pro Ala Asp 
        355                 360                 365             


Trp Lys Ser Asp Arg Ala His Pro Leu Glu Ile Val Lys Glu Leu Arg 
    370                 375                 380                 


Asn Ala Val Asp Asp His Val Thr Val Thr Cys Asp Ile Gly Ser His 
385                 390                 395                 400 


Ala Ile Trp Met Ser Arg Tyr Phe Arg Ser Tyr Glu Pro Leu Thr Leu 
                405                 410                 415     


Met Ile Ser Asn Gly Met Gln Thr Leu Gly Val Ala Leu Pro Trp Ala 
            420                 425                 430         


Ile Gly Ala Ser Leu Val Lys Pro Gly Glu Lys Val Val Ser Val Ser 
        435                 440                 445             


Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala Val 
    450                 455                 460                 


Arg Leu Lys Ala Pro Ile Val His Ile Val Trp Asn Asp Ser Thr Tyr 
465                 470                 475                 480 


Asp Met Val Ala Phe Gln Gln Leu Lys Lys Tyr Asn Arg Thr Ser Ala 
                485                 490                 495     


Val Asp Phe Gly Asn Ile Asp Ile Val Lys Tyr Ala Glu Ser Phe Gly 
            500                 505                 510         


Ala Thr Gly Leu Arg Val Glu Ser Pro Asp Gln Leu Ala Asp Val Leu 
        515                 520                 525             


Arg Gln Gly Met Asn Ala Glu Gly Pro Val Ile Ile Asp Val Pro Val 
    530                 535                 540                 


Asp Tyr Ser Asp Asn Ile Asn Leu Ala Ser Asp Lys Leu Pro Lys Glu 
545                 550                 555                 560 


Phe Gly Glu Leu Met Lys Thr Lys Ala Leu 
                565                 570 


<210>  2
<211>  491
<212>  PRT
<213>  Escherichia coli

<400>  2

Met Ala Asn Tyr Phe Asn Thr Leu Asn Leu Arg Gln Gln Leu Ala Gln 
1               5                   10                  15      


Leu Gly Lys Cys Arg Phe Met Gly Arg Asp Glu Phe Ala Asp Gly Ala 
            20                  25                  30          


Ser Tyr Leu Gln Gly Lys Lys Val Val Ile Val Gly Cys Gly Ala Gln 
        35                  40                  45              


Gly Leu Asn Gln Gly Leu Asn Met Arg Asp Ser Gly Leu Asp Ile Ser 
    50                  55                  60                  


Tyr Ala Leu Arg Lys Glu Ala Ile Ala Glu Lys Arg Ala Ser Trp Arg 
65                  70                  75                  80  


Lys Ala Thr Glu Asn Gly Phe Lys Val Gly Thr Tyr Glu Glu Leu Ile 
                85                  90                  95      


Pro Gln Ala Asp Leu Val Ile Asn Leu Thr Pro Asp Lys Gln His Ser 
            100                 105                 110         


Asp Val Val Arg Thr Val Gln Pro Leu Met Lys Asp Gly Ala Ala Leu 
        115                 120                 125             


Gly Tyr Ser His Gly Phe Asn Ile Val Glu Val Gly Glu Gln Ile Arg 
    130                 135                 140                 


Lys Asp Ile Thr Val Val Met Val Ala Pro Lys Cys Pro Gly Thr Glu 
145                 150                 155                 160 


Val Arg Glu Glu Tyr Lys Arg Gly Phe Gly Val Pro Thr Leu Ile Ala 
                165                 170                 175     


Val His Pro Glu Asn Asp Pro Lys Gly Glu Gly Met Ala Ile Ala Lys 
            180                 185                 190         


Ala Trp Ala Ala Ala Thr Gly Gly His Arg Ala Gly Val Leu Glu Ser 
        195                 200                 205             


Ser Phe Val Ala Glu Val Lys Ser Asp Leu Met Gly Glu Gln Thr Ile 
    210                 215                 220                 


Leu Cys Gly Met Leu Gln Ala Gly Ser Leu Leu Cys Phe Asp Lys Leu 
225                 230                 235                 240 


Val Glu Glu Gly Thr Asp Pro Ala Tyr Ala Glu Lys Leu Ile Gln Phe 
                245                 250                 255     


Gly Trp Glu Thr Ile Thr Glu Ala Leu Lys Gln Gly Gly Ile Thr Leu 
            260                 265                 270         


Met Met Asp Arg Leu Ser Asn Pro Ala Lys Leu Arg Ala Tyr Ala Leu 
        275                 280                 285             


Ser Glu Gln Leu Lys Glu Ile Met Ala Pro Leu Phe Gln Lys His Met 
    290                 295                 300                 


Asp Asp Ile Ile Ser Gly Glu Phe Ser Ser Gly Met Met Ala Asp Trp 
305                 310                 315                 320 


Ala Asn Asp Asp Lys Lys Leu Leu Thr Trp Arg Glu Glu Thr Gly Lys 
                325                 330                 335     


Thr Ala Phe Glu Thr Ala Pro Gln Tyr Glu Gly Lys Ile Gly Glu Gln 
            340                 345                 350         


Glu Tyr Phe Asp Lys Gly Val Leu Met Ile Ala Met Val Lys Ala Gly 
        355                 360                 365             


Val Glu Leu Ala Phe Glu Thr Met Val Asp Ser Gly Ile Ile Glu Glu 
    370                 375                 380                 


Ser Ala Tyr Tyr Glu Ser Leu His Glu Leu Pro Leu Ile Ala Asn Thr 
385                 390                 395                 400 


Ile Ala Arg Lys Arg Leu Tyr Glu Met Asn Val Val Ile Ser Asp Thr 
                405                 410                 415     


Ala Glu Tyr Gly Asn Tyr Leu Phe Ser Tyr Ala Cys Val Pro Leu Leu 
            420                 425                 430         


Lys Pro Phe Met Ala Glu Leu Gln Pro Gly Asp Leu Gly Lys Ala Ile 
        435                 440                 445             


Pro Glu Gly Ala Val Asp Asn Gly Gln Leu Arg Asp Val Asn Glu Ala 
    450                 455                 460                 


Ile Arg Ser His Ala Ile Glu Gln Val Gly Lys Lys Leu Arg Gly Tyr 
465                 470                 475                 480 


Met Thr Asp Met Lys Arg Ile Ala Val Ala Gly 
                485                 490     


<210>  3
<211>  570
<212>  PRT
<213>  Lactococcus lactis

<400>  3

Met Glu Phe Lys Tyr Asn Gly Lys Val Glu Ser Val Glu Leu Asn Lys 
1               5                   10                  15      


Tyr Ser Lys Thr Leu Thr Gln Asp Pro Thr Gln Pro Ala Thr Gln Ala 
            20                  25                  30          


Met Tyr Tyr Gly Ile Gly Phe Lys Asp Glu Asp Phe Lys Lys Ala Gln 
        35                  40                  45              


Val Gly Ile Val Ser Met Asp Trp Asp Gly Asn Pro Cys Asn Met His 
    50                  55                  60                  


Leu Gly Thr Leu Gly Ser Lys Ile Lys Ser Ser Val Asn Gln Thr Asp 
65                  70                  75                  80  


Gly Leu Ile Gly Leu Gln Phe His Thr Ile Gly Val Ser Asp Gly Ile 
                85                  90                  95      


Ala Asn Gly Lys Leu Gly Met Arg Tyr Ser Leu Val Ser Arg Glu Val 
            100                 105                 110         


Ile Ala Asp Ser Ile Glu Thr Asn Ala Gly Ala Glu Tyr Tyr Asp Ala 
        115                 120                 125             


Ile Val Ala Ile Pro Gly Cys Asp Lys Asn Met Pro Gly Ser Ile Ile 
    130                 135                 140                 


Gly Met Ala Arg Leu Asn Arg Pro Ser Ile Met Val Tyr Gly Gly Thr 
145                 150                 155                 160 


Ile Glu His Gly Glu Tyr Lys Gly Glu Lys Leu Asn Ile Val Ser Ala 
                165                 170                 175     


Phe Glu Ser Leu Gly Gln Lys Ile Thr Gly Asn Ile Ser Asp Glu Asp 
            180                 185                 190         


Tyr His Gly Val Ile Cys Asn Ala Ile Pro Gly Gln Gly Ala Cys Gly 
        195                 200                 205             


Gly Met Tyr Thr Ala Asn Thr Leu Ala Ala Ala Ile Glu Thr Leu Gly 
    210                 215                 220                 


Met Ser Leu Pro Tyr Ser Ser Ser Asn Pro Ala Val Ser Gln Glu Lys 
225                 230                 235                 240 


Gln Glu Glu Cys Asp Glu Ile Gly Leu Ala Ile Lys Asn Leu Leu Glu 
                245                 250                 255     


Lys Asp Ile Lys Pro Ser Asp Ile Met Thr Lys Glu Ala Phe Glu Asn 
            260                 265                 270         


Ala Ile Thr Ile Val Met Val Leu Gly Gly Ser Thr Asn Ala Val Leu 
        275                 280                 285             


His Ile Ile Ala Met Ala Asn Ala Ile Gly Val Glu Ile Thr Gln Asp 
    290                 295                 300                 


Asp Phe Gln Arg Ile Ser Asp Ile Thr Pro Val Leu Gly Asp Phe Lys 
305                 310                 315                 320 


Pro Ser Gly Lys Tyr Met Met Glu Asp Leu His Lys Ile Gly Gly Leu 
                325                 330                 335     


Pro Ala Val Leu Lys Tyr Leu Leu Lys Glu Gly Lys Leu His Gly Asp 
            340                 345                 350         


Cys Leu Thr Val Thr Gly Lys Thr Leu Ala Glu Asn Val Glu Thr Ala 
        355                 360                 365             


Leu Asp Leu Asp Phe Asp Ser Gln Asp Ile Met Arg Pro Leu Lys Asn 
    370                 375                 380                 


Pro Ile Lys Ala Thr Gly His Leu Gln Ile Leu Tyr Gly Asn Leu Ala 
385                 390                 395                 400 


Gln Gly Gly Ser Val Ala Lys Ile Ser Gly Lys Glu Gly Glu Phe Phe 
                405                 410                 415     


Lys Gly Thr Ala Arg Val Phe Asp Gly Glu Gln His Phe Ile Asp Gly 
            420                 425                 430         


Ile Glu Ser Gly Arg Leu His Ala Gly Asp Val Ala Val Ile Arg Asn 
        435                 440                 445             


Ile Gly Pro Val Gly Gly Pro Gly Met Pro Glu Met Leu Lys Pro Thr 
    450                 455                 460                 


Ser Ala Leu Ile Gly Ala Gly Leu Gly Lys Ser Cys Ala Leu Ile Thr 
465                 470                 475                 480 


Asp Gly Arg Phe Ser Gly Gly Thr His Gly Phe Val Val Gly His Ile 
                485                 490                 495     


Val Pro Glu Ala Val Glu Gly Gly Leu Ile Gly Leu Val Glu Asp Asp 
            500                 505                 510         


Asp Ile Ile Glu Ile Asp Ala Val Asn Asn Ser Ile Ser Leu Lys Val 
        515                 520                 525             


Ser Asp Glu Glu Ile Ala Lys Arg Arg Ala Asn Tyr Gln Lys Pro Thr 
    530                 535                 540                 


Pro Lys Ala Thr Arg Gly Val Leu Ala Lys Phe Ala Lys Leu Thr Arg 
545                 550                 555                 560 


Pro Ala Ser Glu Gly Cys Val Thr Asp Leu 
                565                 570 


<210>  4
<211>  548
<212>  PRT
<213>  Lactococcus lactis

<400>  4

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser His Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Thr Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Arg Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Ser Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Gly Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  5
<211>  499
<212>  PRT
<213>  Escherichia coli

<400>  5

Met Thr Glu Pro His Val Ala Val Leu Ser Gln Val Gln Gln Phe Leu 
1               5                   10                  15      


Asp Arg Gln His Gly Leu Tyr Ile Asp Gly Arg Pro Gly Pro Ala Gln 
            20                  25                  30          


Ser Glu Lys Arg Leu Ala Ile Phe Asp Pro Ala Thr Gly Gln Glu Ile 
        35                  40                  45              


Ala Ser Thr Ala Asp Ala Asn Glu Ala Asp Val Asp Asn Ala Val Met 
    50                  55                  60                  


Ser Ala Trp Arg Ala Phe Val Ser Arg Arg Trp Ala Gly Arg Leu Pro 
65                  70                  75                  80  


Ala Glu Arg Glu Arg Ile Leu Leu Arg Phe Ala Asp Leu Val Glu Gln 
                85                  90                  95      


His Ser Glu Glu Leu Ala Gln Leu Glu Thr Leu Glu Gln Gly Lys Ser 
            100                 105                 110         


Ile Ala Ile Ser Arg Ala Phe Glu Val Gly Cys Thr Leu Asn Trp Met 
        115                 120                 125             


Arg Tyr Thr Ala Gly Leu Thr Thr Lys Ile Ala Gly Lys Thr Leu Asp 
    130                 135                 140                 


Leu Ser Ile Pro Leu Pro Gln Gly Ala Arg Tyr Gln Ala Trp Thr Arg 
145                 150                 155                 160 


Lys Glu Pro Val Gly Val Val Ala Gly Ile Val Pro Trp Asn Phe Pro 
                165                 170                 175     


Leu Met Ile Gly Met Trp Lys Val Met Pro Ala Leu Ala Ala Gly Cys 
            180                 185                 190         


Ser Ile Val Ile Lys Pro Ser Glu Thr Thr Pro Leu Thr Met Leu Arg 
        195                 200                 205             


Val Ala Glu Leu Ala Ser Glu Ala Gly Ile Pro Asp Gly Val Phe Asn 
    210                 215                 220                 


Val Val Thr Gly Ser Gly Ala Val Cys Gly Ala Ala Leu Thr Ser His 
225                 230                 235                 240 


Pro His Val Ala Lys Ile Ser Phe Thr Gly Ser Thr Ala Thr Gly Lys 
                245                 250                 255     


Gly Ile Ala Arg Thr Ala Ala Asp His Leu Thr Arg Val Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Asn Pro Ala Ile Val Leu Lys Asp Ala Asp Pro Gln 
        275                 280                 285             


Trp Val Ile Glu Gly Leu Met Thr Gly Ser Phe Leu Asn Gln Gly Gln 
    290                 295                 300                 


Val Cys Ala Ala Ser Ser Arg Ile Tyr Ile Glu Ala Pro Leu Phe Asp 
305                 310                 315                 320 


Thr Leu Val Ser Gly Phe Glu Gln Ala Val Lys Ser Leu Gln Val Gly 
                325                 330                 335     


Pro Gly Met Ser Pro Val Ala Gln Ile Asn Pro Leu Val Ser Arg Ala 
            340                 345                 350         


His Cys Asp Lys Val Cys Ser Phe Leu Asp Asp Ala Gln Ala Gln Gln 
        355                 360                 365             


Ala Glu Leu Ile Arg Gly Ser Asn Gly Pro Ala Gly Glu Gly Tyr Tyr 
    370                 375                 380                 


Val Ala Pro Thr Leu Val Val Asn Pro Asp Ala Lys Leu Arg Leu Thr 
385                 390                 395                 400 


Arg Glu Glu Val Phe Gly Pro Val Val Asn Leu Val Arg Val Ala Asp 
                405                 410                 415     


Gly Glu Glu Ala Leu Gln Leu Ala Asn Asp Thr Glu Tyr Gly Leu Thr 
            420                 425                 430         


Ala Ser Val Trp Thr Gln Asn Leu Ser Gln Ala Leu Glu Tyr Ser Asp 
        435                 440                 445             


Arg Leu Gln Ala Gly Thr Val Trp Val Asn Ser His Thr Leu Ile Asp 
    450                 455                 460                 


Ala Asn Leu Pro Phe Gly Gly Met Lys Gln Ser Gly Thr Gly Arg Asp 
465                 470                 475                 480 


Phe Gly Pro Asp Trp Leu Asp Gly Trp Cys Glu Thr Lys Ser Val Cys 
                485                 490                 495     


Val Arg Tyr 
            


<210>  6
<211>  563
<212>  PRT
<213>  Pichia kudriavzevii

<400>  6

Met Ile Pro Arg Leu Asn Pro Leu Leu Asn Ile Ser His Leu Arg Gly 
1               5                   10                  15      


Gly Pro Lys Phe Ile Gly Lys Ala Ile Lys Pro Ser Gln Phe Glu Phe 
            20                  25                  30          


Arg Lys Asn Asn Phe Arg Phe Asn Ser Thr Ser Thr Lys Thr Gly Ser 
        35                  40                  45              


Ala Arg Thr Ile Lys Ser Gly Phe Leu Ser Trp Ser Phe Arg Ala Ala 
    50                  55                  60                  


Thr Phe Thr Gly Ile Ala Gly Trp Leu Tyr Leu Thr Tyr Leu Val Tyr 
65                  70                  75                  80  


Lys Glu Thr Asn Pro Gly Ser Gln Ser Pro Gln Thr Glu Phe Ser Glu 
                85                  90                  95      


Ile Gly Asn Lys Lys Lys Asn Ile Val Ile Leu Gly Ser Gly Trp Gly 
            100                 105                 110         


Ala Val Ser Val Leu Lys Thr Leu Asp Thr Thr Lys Tyr Asn Val Thr 
        115                 120                 125             


Ile Val Ser Pro Arg Asn Tyr Phe Leu Phe Thr Pro Leu Leu Pro Ser 
    130                 135                 140                 


Val Pro Ser Gly Thr Ile Asp Ile Lys Ser Ile Cys Asp Ser Ile Arg 
145                 150                 155                 160 


Thr Ile Ala Arg Gln Thr Pro Gly Glu Val Thr Tyr Leu Glu Ala Ala 
                165                 170                 175     


Ala Thr Asp Ile Asp Pro Val Lys Lys Thr Ile Lys Leu Glu His Lys 
            180                 185                 190         


Ser Gln Arg Phe Leu Ile Gly Asp Ala Phe Thr Ser Glu Gly Asp Val 
        195                 200                 205             


Ile Glu Asn Glu Leu Ser Tyr Asp Tyr Leu Val Tyr Ala Val Gly Ala 
    210                 215                 220                 


Thr Val Asn Thr Phe Gly Ile Pro Gly Ile Pro Glu Tyr Ala Ser Tyr 
225                 230                 235                 240 


Leu Lys Glu Ala Asn Asp Ala Thr Ala Val Arg Gln Lys Leu Phe Asn 
                245                 250                 255     


Gln Ile Glu Ala Ser Arg Leu Leu Pro Lys Asp Ser Glu Asp Arg Lys 
            260                 265                 270         


Arg Leu Leu Ser Phe Val Val Cys Gly Gly Gly Pro Thr Gly Val Glu 
        275                 280                 285             


Leu Ala Ala Glu Ile Lys Asp Tyr Ile Asp Gln Asp Leu Cys Lys Phe 
    290                 295                 300                 


Ile Pro Gly Ile Glu Lys Glu Met Gln Val Thr Leu Ile Glu Ala Gln 
305                 310                 315                 320 


His Asn Val Leu Ser Met Phe His Pro Lys Leu Ile Glu Tyr Thr Lys 
                325                 330                 335     


Glu Val Phe Lys Gln Gln Asn Leu His Leu Gln Val Asp Thr Met Val 
            340                 345                 350         


Lys Lys Val Asp Asp Lys Asn Val Tyr Ala Thr Tyr Arg His Pro Asp 
        355                 360                 365             


Gly Lys Thr Glu Asp Met Val Ile Pro Tyr Gly Thr Leu Val Trp Ala 
    370                 375                 380                 


Gly Gly Asn Ala Gln Arg Lys Leu Thr Arg Asp Leu Ser Ser Lys Ile 
385                 390                 395                 400 


Ile Glu Gln Lys Thr Ala Arg Arg Gly Leu Leu Val Asp Glu Tyr Leu 
                405                 410                 415     


Lys Leu Asp Gly Asp Asp Ser Ile Tyr Ala Ile Gly Asp Cys Thr Phe 
            420                 425                 430         


Thr Pro Asn Pro Pro Thr Ala Gln Val Ala His Gln Gln Gly Glu Tyr 
        435                 440                 445             


Leu Gly Glu His Phe Asn Lys Leu Ala Lys Ile Asp Glu Leu Asn Tyr 
    450                 455                 460                 


Leu Ile Thr Asn Ser Thr Asp Asp Ser Thr Lys Tyr Ser Lys Arg Leu 
465                 470                 475                 480 


Glu Arg Ala Glu Lys Ala Ile Lys Pro Phe Glu Tyr Asp His Gln Gly 
                485                 490                 495     


Ala Leu Ala Tyr Val Gly Ser Glu Arg Ala Val Ala Asp Leu His Trp 
            500                 505                 510         


Gly Ser Trp Ser Thr Val Ala Leu Gly Gly Thr Met Thr Phe Phe Phe 
        515                 520                 525             


Trp Arg Thr Ala Tyr Val Ser Met Leu Leu Ser Ile Arg Asn Lys Ile 
    530                 535                 540                 


Leu Val Val Thr Asp Trp Val Lys Val Ala Ile Phe Gly Arg Asp Cys 
545                 550                 555                 560 


Ser Gln Glu 
            


<210>  7
<211>  446
<212>  PRT
<213>  Lactococcus lactis

<400>  7

Met Lys Ile Val Val Ile Gly Thr Asn His Ala Gly Ile Ala Thr Ala 
1               5                   10                  15      


Asn Thr Leu Ile Asp Arg Tyr Pro Gly His Glu Ile Val Met Ile Asp 
            20                  25                  30          


Arg Asn Ser Asn Met Ser Tyr Leu Gly Cys Gly Thr Ala Ile Trp Val 
        35                  40                  45              


Gly Arg Gln Ile Glu Lys Pro Asp Glu Leu Phe Tyr Ala Lys Ala Glu 
    50                  55                  60                  


Asp Phe Glu Lys Lys Gly Val Lys Ile Leu Thr Glu Thr Glu Val Ser 
65                  70                  75                  80  


Glu Ile Asp Phe Thr Asn Lys Met Ile Tyr Ala Lys Ser Lys Thr Gly 
                85                  90                  95      


Glu Lys Ile Thr Glu Ser Tyr Asp Lys Leu Val Leu Ala Thr Gly Ser 
            100                 105                 110         


Arg Pro Ile Ile Pro Asn Leu Pro Gly Lys Asp Leu Lys Gly Ile His 
        115                 120                 125             


Phe Leu Lys Leu Phe Gln Glu Gly Gln Ala Ile Asp Glu Glu Phe Ala 
    130                 135                 140                 


Lys Asn Asp Val Lys Arg Ile Ala Val Ile Gly Ala Gly Tyr Ile Gly 
145                 150                 155                 160 


Thr Glu Ile Ala Glu Ala Ala Lys Arg Arg Gly Lys Glu Val Leu Leu 
                165                 170                 175     


Phe Asp Ala Glu Ser Thr Ser Leu Ala Ser Tyr Tyr Asp Glu Glu Phe 
            180                 185                 190         


Ala Lys Gly Met Asp Glu Asn Leu Ala Gln His Gly Ile Glu Leu His 
        195                 200                 205             


Phe Gly Glu Leu Ala Gln Glu Phe Lys Ala Asn Glu Lys Gly His Val 
    210                 215                 220                 


Ser Gln Ile Val Thr Asn Lys Ser Thr Tyr Asp Val Asp Leu Val Ile 
225                 230                 235                 240 


Asn Cys Ile Gly Phe Thr Ala Asn Ser Ala Leu Ala Gly Glu His Leu 
                245                 250                 255     


Glu Thr Phe Lys Asn Gly Ala Ile Lys Val Asp Lys His Gln Gln Ser 
            260                 265                 270         


Ser Asp Pro Asp Val Ser Ala Val Gly Asp Val Ala Thr Ile Tyr Ser 
        275                 280                 285             


Asn Ala Leu Gln Asp Phe Thr Tyr Ile Ala Leu Ala Ser Asn Ala Val 
    290                 295                 300                 


Arg Ser Gly Ile Val Ala Gly His Asn Ile Gly Gly Lys Ser Ile Glu 
305                 310                 315                 320 


Ser Val Gly Val Gln Gly Ser Asn Gly Ile Ser Ile Phe Gly Tyr Asn 
                325                 330                 335     


Met Thr Ser Thr Gly Leu Ser Val Lys Ala Ala Lys Lys Ile Gly Leu 
            340                 345                 350         


Glu Val Ser Phe Ser Asp Phe Glu Asp Lys Gln Lys Ala Trp Phe Leu 
        355                 360                 365             


His Glu Asn Asn Asp Ser Val Lys Ile Arg Ile Val Tyr Glu Thr Lys 
    370                 375                 380                 


Asn Arg Arg Ile Ile Gly Ala Gln Leu Ala Ser Lys Ser Glu Ile Ile 
385                 390                 395                 400 


Ala Gly Asn Ile Asn Met Phe Ser Leu Ala Ile Gln Glu Lys Lys Thr 
                405                 410                 415     


Ile Asp Glu Leu Ala Leu Leu Asp Leu Phe Phe Leu Pro His Phe Asn 
            420                 425                 430         


Ser Pro Tyr Asn Tyr Met Thr Val Ala Ala Leu Asn Ala Lys 
        435                 440                 445     


<210>  8
<211>  575
<212>  PRT
<213>  Pichia kudriavzevii

<400>  8

Met Thr Asp Lys Ile Ser Leu Gly Thr Tyr Leu Phe Glu Lys Leu Lys 
1               5                   10                  15      


Glu Ala Gly Ser Tyr Ser Ile Phe Gly Val Pro Gly Asp Phe Asn Leu 
            20                  25                  30          


Ala Leu Leu Asp His Val Lys Glu Val Glu Gly Ile Arg Trp Val Gly 
        35                  40                  45              


Asn Ala Asn Glu Leu Asn Ala Gly Tyr Glu Ala Asp Gly Tyr Ala Arg 
    50                  55                  60                  


Ile Asn Gly Phe Ala Ser Leu Ile Thr Thr Phe Gly Val Gly Glu Leu 
65                  70                  75                  80  


Ser Ala Val Asn Ala Ile Ala Gly Ser Tyr Ala Glu His Val Pro Leu 
                85                  90                  95      


Ile His Ile Val Gly Met Pro Ser Leu Ser Ala Met Lys Asn Asn Leu 
            100                 105                 110         


Leu Leu His His Thr Leu Gly Asp Thr Arg Phe Asp Asn Phe Thr Glu 
        115                 120                 125             


Met Ser Lys Lys Ile Ser Ala Lys Val Glu Ile Val Tyr Asp Leu Glu 
    130                 135                 140                 


Ser Ala Pro Lys Leu Ile Asn Asn Leu Ile Glu Thr Ala Tyr His Thr 
145                 150                 155                 160 


Lys Arg Pro Val Tyr Leu Gly Leu Pro Ser Asn Phe Ala Asp Glu Leu 
                165                 170                 175     


Val Pro Ala Ala Leu Val Lys Glu Asn Lys Leu His Leu Glu Glu Pro 
            180                 185                 190         


Leu Asn Asn Pro Val Ala Glu Glu Glu Phe Ile His Asn Val Val Glu 
        195                 200                 205             


Met Val Lys Lys Ala Glu Lys Pro Ile Ile Leu Val Asp Ala Cys Ala 
    210                 215                 220                 


Ala Arg His Asn Ile Ser Lys Glu Val Arg Glu Leu Ala Lys Leu Thr 
225                 230                 235                 240 


Lys Phe Pro Val Phe Thr Thr Pro Met Gly Lys Ser Thr Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Glu Phe Phe Gly Leu Tyr Leu Gly Ser Leu Ser Ala Pro 
            260                 265                 270         


Asp Val Lys Asp Ile Val Gly Pro Thr Asp Cys Ile Leu Ser Leu Gly 
        275                 280                 285             


Gly Leu Pro Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Gly Tyr Thr 
    290                 295                 300                 


Thr Lys Asn Val Val Glu Phe His Ser Asn Tyr Cys Lys Phe Lys Ser 
305                 310                 315                 320 


Ala Thr Tyr Glu Asn Leu Met Met Lys Gly Ala Val Gln Arg Leu Ile 
                325                 330                 335     


Ser Glu Leu Lys Asn Ile Lys Tyr Ser Asn Val Ser Thr Leu Ser Pro 
            340                 345                 350         


Pro Lys Ser Lys Phe Ala Tyr Glu Ser Ala Lys Val Ala Pro Glu Gly 
        355                 360                 365             


Ile Ile Thr Gln Asp Tyr Leu Trp Lys Arg Leu Ser Tyr Phe Leu Lys 
    370                 375                 380                 


Pro Arg Asp Ile Ile Val Thr Glu Thr Gly Thr Ser Ser Phe Gly Val 
385                 390                 395                 400 


Leu Ala Thr His Leu Pro Arg Asp Ser Lys Ser Ile Ser Gln Val Leu 
                405                 410                 415     


Trp Gly Ser Ile Gly Phe Ser Leu Pro Ala Ala Val Gly Ala Ala Phe 
            420                 425                 430         


Ala Ala Glu Asp Ala His Lys Gln Thr Gly Glu Gln Glu Arg Arg Thr 
        435                 440                 445             


Val Leu Phe Ile Gly Asp Gly Ser Leu Gln Leu Thr Val Gln Ser Ile 
    450                 455                 460                 


Ser Asp Ala Ala Arg Trp Asn Ile Lys Pro Tyr Ile Phe Ile Leu Asn 
465                 470                 475                 480 


Asn Arg Gly Tyr Thr Ile Glu Lys Leu Ile His Gly Arg His Glu Asp 
                485                 490                 495     


Tyr Asn Gln Ile Gln Pro Trp Asp His Gln Leu Leu Leu Lys Leu Phe 
            500                 505                 510         


Ala Asp Lys Thr Gln Tyr Glu Asn His Val Val Lys Ser Ala Lys Asp 
        515                 520                 525             


Leu Asp Ala Leu Met Lys Asp Glu Ala Phe Asn Lys Glu Asp Lys Ile 
    530                 535                 540                 


Arg Val Ile Glu Leu Phe Leu Asp Glu Phe Asp Ala Pro Glu Ile Leu 
545                 550                 555                 560 


Val Ala Gln Ala Lys Leu Ser Asp Glu Ile Asn Ser Lys Ala Ala 
                565                 570                 575 


<210>  9
<211>  608
<212>  PRT
<213>  Pichia kudriavzevii

<400>  9

Met Leu Gln Thr Ala Asn Ser Glu Val Pro Asn Ala Ser Gln Ile Thr 
1               5                   10                  15      


Ile Asp Ala Ala Ser Gly Leu Pro Ala Asp Arg Val Leu Pro Asn Ile 
            20                  25                  30          


Thr Asn Thr Glu Ile Thr Ile Ser Glu Tyr Ile Phe Tyr Arg Ile Leu 
        35                  40                  45              


Gln Leu Gly Val Arg Ser Val Phe Gly Val Pro Gly Asp Phe Asn Leu 
    50                  55                  60                  


Arg Phe Leu Glu His Ile Tyr Asp Val His Gly Leu Asn Trp Ile Gly 
65                  70                  75                  80  


Cys Cys Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Ala Tyr Ala Lys 
                85                  90                  95      


Ala Ser Lys Lys Met Gly Val Leu Leu Thr Thr Tyr Gly Val Gly Glu 
            100                 105                 110         


Leu Ser Ala Leu Asn Gly Val Ala Gly Ala Tyr Thr Glu Phe Ala Pro 
        115                 120                 125             


Val Leu His Leu Val Gly Thr Ser Ala Leu Lys Phe Lys Arg Asn Pro 
    130                 135                 140                 


Arg Thr Leu Asn Leu His His Leu Ala Gly Asp Lys Lys Thr Phe Lys 
145                 150                 155                 160 


Lys Ser Asp His Tyr Lys Tyr Glu Arg Ile Ala Ser Glu Phe Ser Val 
                165                 170                 175     


Asp Ser Ala Ser Ile Glu Asp Asp Pro Ile Glu Ala Cys Glu Met Ile 
            180                 185                 190         


Asp Arg Val Ile Tyr Ser Thr Trp Arg Glu Ser Arg Pro Gly Tyr Ile 
        195                 200                 205             


Phe Leu Pro Cys Asp Leu Ser Glu Met Lys Val Asp Ala Gln Arg Leu 
    210                 215                 220                 


Ala Ser Pro Ile Glu Leu Thr Tyr Arg Phe Asn Ser Pro Val Ser Arg 
225                 230                 235                 240 


Val Glu Gly Val Ala Asp Gln Ile Leu Gln Leu Ile Tyr Gln Asn Lys 
                245                 250                 255     


Asn Val Ser Ile Ile Val Asp Gly Phe Ile Arg Lys Phe Arg Met Glu 
            260                 265                 270         


Ser Glu Phe Tyr Asp Ile Met Glu Lys Phe Gly Asp Lys Val Asn Ile 
        275                 280                 285             


Phe Ser Thr Met Tyr Gly Lys Gly Leu Ile Gly Glu Glu His Pro Arg 
    290                 295                 300                 


Phe Val Gly Thr Tyr Phe Gly Lys Tyr Glu Lys Ala Val Gly Asn Leu 
305                 310                 315                 320 


Leu Glu Ala Ser Asp Leu Ile Ile His Phe Gly Asn Phe Asp His Glu 
                325                 330                 335     


Leu Asn Met Gly Gly Phe Thr Phe Asn Ile Pro Gln Glu Lys Tyr Ile 
            340                 345                 350         


Asp Leu Ser Ala Gln Tyr Val Asp Ile Thr Gly Asn Leu Asp Glu Ser 
        355                 360                 365             


Ile Thr Met Met Glu Val Leu Pro Val Leu Ala Ser Lys Leu Asp Ser 
    370                 375                 380                 


Ser Arg Val Asn Val Ala Asp Lys Phe Glu Lys Phe Asp Lys Tyr Tyr 
385                 390                 395                 400 


Glu Thr Pro Asp Tyr Gln Arg Glu Ala Ser Leu Gln Glu Thr Asp Ile 
                405                 410                 415     


Met Gln Ser Leu Asn Glu Asn Leu Thr Gly Asp Asp Ile Leu Ile Val 
            420                 425                 430         


Glu Thr Cys Ser Phe Leu Phe Ala Val Pro Asp Leu Lys Val Lys Gln 
        435                 440                 445             


His Thr Asn Ile Ile Leu Gln Ala Tyr Trp Ala Ser Ile Gly Tyr Ala 
    450                 455                 460                 


Leu Pro Ala Thr Leu Gly Ala Ser Leu Ala Ile Arg Asp Phe Asn Leu 
465                 470                 475                 480 


Ser Gly Lys Val Tyr Thr Ile Glu Gly Asp Gly Ser Ala Gln Met Ser 
                485                 490                 495     


Leu Gln Glu Leu Ser Ser Met Leu Arg Tyr Asn Ile Asp Ala Thr Met 
            500                 505                 510         


Ile Leu Leu Asn Asn Ser Gly Tyr Thr Ile Glu Arg Val Ile Val Gly 
        515                 520                 525             


Pro His Ser Ser Tyr Asn Asp Ile Asn Thr Asn Trp Gln Trp Thr Asp 
    530                 535                 540                 


Leu Leu Arg Ala Phe Gly Asp Val Ala Asn Glu Lys Ser Val Ser Tyr 
545                 550                 555                 560 


Thr Ile Lys Glu Arg Glu Gln Leu Leu Asn Ile Leu Ser Asp Pro Ser 
                565                 570                 575     


Phe Lys His Asn Gly Lys Phe Arg Leu Leu Glu Cys Val Leu Pro Met 
            580                 585                 590         


Phe Asp Val Pro Lys Lys Leu Gly Gln Phe Thr Gly Lys Ile Pro Ala 
        595                 600                 605             


<210>  10
<211>  584
<212>  PRT
<213>  Pichia kudriavzevii

<400>  10

Met Ala Pro Val Ser Leu Glu Thr Cys Thr Leu Glu Phe Ser Cys Lys 
1               5                   10                  15      


Leu Pro Leu Ser Glu Tyr Ile Phe Arg Arg Ile Ala Ser Leu Gly Ile 
            20                  25                  30          


His Asn Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Ser Phe Leu Glu 
        35                  40                  45              


His Leu Tyr Ser Val Pro Glu Leu Ser Trp Val Gly Cys Cys Asn Glu 
    50                  55                  60                  


Leu Asn Ser Ala Tyr Ala Thr Asp Gly Tyr Ser Arg Thr Ile Gly His 
65                  70                  75                  80  


Asp Lys Phe Gly Val Leu Leu Thr Thr Gln Gly Val Gly Glu Leu Ser 
                85                  90                  95      


Ala Ala Asn Ala Ile Ala Gly Ser Phe Ala Glu His Val Pro Ile Leu 
            100                 105                 110         


His Ile Val Gly Thr Thr Pro Tyr Ser Leu Lys His Lys Gly Ser His 
        115                 120                 125             


His His His Leu Ile Asn Gly Val Ser Thr Arg Glu Pro Thr Asn His 
    130                 135                 140                 


Tyr Ala Tyr Glu Glu Met Ser Lys Asn Ile Ser Cys Lys Ile Leu Ser 
145                 150                 155                 160 


Leu Ser Asp Asp Leu Thr Asn Ala Ala Asn Glu Ile Asp Asp Leu Phe 
                165                 170                 175     


Arg Thr Ile Leu Met Leu Lys Lys Pro Gly Tyr Leu Tyr Ile Pro Cys 
            180                 185                 190         


Asp Leu Val Asn Val Glu Ile Asp Ala Ser Asn Leu Gln Ser Val Pro 
        195                 200                 205             


Ala Asn Lys Leu Arg Glu Arg Val Pro Ser Thr Asp Ser Gln Thr Ile 
    210                 215                 220                 


Ala Lys Ile Thr Ser Thr Ile Val Asp Lys Leu Leu Ser Ser Ser Asn 
225                 230                 235                 240 


Pro Val Val Leu Cys Asp Ile Leu Thr Asp Arg Tyr Gly Met Thr Ala 
                245                 250                 255     


Tyr Ala Gln Asp Leu Val Asp Ser Leu Lys Val Pro Cys Cys Asn Ser 
            260                 265                 270         


Phe Met Gly Lys Ala Leu Leu Asn Glu Ser Lys Glu His Tyr Ile Gly 
        275                 280                 285             


Asp Phe Asn Gly Glu Glu Ser Asn Lys Met Val His Ser Tyr Ile Ser 
    290                 295                 300                 


Asn Thr Asp Cys Phe Leu His Ile Gly Asp Tyr Tyr Asn Glu Ile Asn 
305                 310                 315                 320 


Ser Gly His Trp Ser Leu Tyr Asn Gly Ile Asn Lys Glu Ser Ile Val 
                325                 330                 335     


Ile Leu Asn Pro Glu Tyr Val Lys Ile Gly Ser Gln Thr Tyr Gln Asn 
            340                 345                 350         


Val Ser Phe Glu Asp Ile Leu Pro Ala Ile Leu Ser Ser Ile Lys Ala 
        355                 360                 365             


Asn Pro Asn Leu Pro Cys Phe His Ile Pro Lys Ile Met Ser Thr Ile 
    370                 375                 380                 


Glu Gln Ile Pro Ser Asn Thr Pro Ile Ser Gln Thr Leu Met Leu Glu 
385                 390                 395                 400 


Lys Leu Gln Ser Phe Leu Lys Pro Asn Asp Val Leu Val Thr Glu Thr 
                405                 410                 415     


Cys Ser Leu Met Phe Gly Leu Pro Asp Ile Arg Met Pro Glu Asn Ser 
            420                 425                 430         


Lys Val Ile Gly Gln His Phe Tyr Leu Ser Ile Gly Met Ala Leu Pro 
        435                 440                 445             


Cys Ser Phe Gly Val Ser Val Ala Leu Asn Glu Leu Lys Lys Asp Ser 
    450                 455                 460                 


Arg Leu Ile Leu Ile Glu Gly Asp Gly Ser Ala Gln Met Thr Val Gln 
465                 470                 475                 480 


Glu Leu Ser Asn Phe Asn Arg Glu Asn Val Val Lys Pro Leu Ile Ile 
                485                 490                 495     


Leu Leu Asn Asn Ser Gly Tyr Thr Val Glu Arg Val Ile Lys Gly Pro 
            500                 505                 510         


Lys Arg Glu Tyr Asn Asp Ile Arg Pro Asp Trp Lys Trp Thr Gln Leu 
        515                 520                 525             


Leu Gln Thr Phe Gly Met Asp Asp Ala Lys Ser Met Lys Val Thr Thr 
    530                 535                 540                 


Pro Glu Glu Leu Asp Asp Ala Leu Asp Glu Tyr Gly Asn Asn Leu Ser 
545                 550                 555                 560 


Thr Pro Arg Leu Leu Glu Val Val Leu Asp Lys Leu Asp Val Pro Trp 
                565                 570                 575     


Arg Phe Asn Lys Met Val Gly Asn 
            580                 


<210>  11
<211>  407
<212>  PRT
<213>  Pichia kudriavzevii

<400>  11

Met Leu Arg Leu Phe Ser Arg Arg Thr Pro Ser Val Arg Ala Leu Pro 
1               5                   10                  15      


Lys Phe Thr Arg Ser Leu Ala Thr Ala Ser Pro Glu Ala Gly Ala Gln 
            20                  25                  30          


Glu Val Ser Asn Leu His Asp Ile Val Glu Ile Glu Leu Pro Glu Tyr 
        35                  40                  45              


Ser Phe Glu Gly Tyr Lys Leu Asp Val Pro Glu Leu Asn Tyr Ser Thr 
    50                  55                  60                  


Glu Lys Gly Thr Leu Leu Gln Met Tyr Lys Asp Met Val Ile Ile Arg 
65                  70                  75                  80  


Arg Met Glu Met Ala Ala Asp Ala Leu Tyr Lys Ala Lys Lys Ile Arg 
                85                  90                  95      


Gly Phe Cys His Leu Ser Val Gly Gln Glu Ala Ile Ala Val Gly Ile 
            100                 105                 110         


Glu Asn Ala Ile Thr Lys Gln Asp Asp Ile Ile Thr Ser Tyr Arg Cys 
        115                 120                 125             


His Gly Thr Thr Tyr Met Arg Gly Ala Ser Val Gln Glu Val Leu Ala 
    130                 135                 140                 


Glu Leu Met Gly Arg Arg Ser Gly Val Ser Tyr Gly Lys Gly Gly Ser 
145                 150                 155                 160 


Met His Met Tyr Thr Lys Gly Phe Tyr Gly Gly Asn Gly Ile Val Gly 
                165                 170                 175     


Ala Gln Val Pro Leu Gly Thr Gly Leu Ala Phe Ala His His Tyr Arg 
            180                 185                 190         


Asp Gln Lys Asn Met Thr Trp Thr Met Tyr Gly Asp Gly Ala Ala Asn 
        195                 200                 205             


Gln Gly Gln Val Phe Glu Ser Phe Asn Met Ala Lys Leu Trp Asn Leu 
    210                 215                 220                 


Pro Cys Val Phe Thr Cys Glu Asn Asn Lys Tyr Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ala Ser Arg Ser Ser Ala Met Thr Glu Tyr Tyr Lys Arg Gly Gln Tyr 
                245                 250                 255     


Ile Pro Gly Leu Lys Val Asn Gly Met Asp Ile Leu Ala Val Tyr Gln 
            260                 265                 270         


Ala Ala Lys Phe Ala Lys Glu Trp Thr Ser Asn Asp Asn Gly Pro Leu 
        275                 280                 285             


Val Ile Glu Phe Glu Thr Tyr Arg Tyr Gly Gly His Ser Met Ser Asp 
    290                 295                 300                 


Pro Gly Thr Thr Tyr Arg Thr Arg Glu Glu Val Gln Asn Met Arg Ser 
305                 310                 315                 320 


Lys Lys Asp Pro Ile Ala Gly Leu Lys Ala His Leu Leu Glu Phe Asn 
                325                 330                 335     


Ile Ala Thr Glu Glu Glu Ile Lys Ala Phe Asp Lys Ser Ala Arg Lys 
            340                 345                 350         


Tyr Val Asp Glu Gln Val Lys Leu Ala Asp Ala Ser Pro Pro Pro Glu 
        355                 360                 365             


Ala Lys Met Ser Ile Leu Phe Glu Asp Val Tyr Val Pro Gly Ser Glu 
    370                 375                 380                 


Ile Pro Val Leu Arg Gly Arg Ile Arg Asp Asp Ser Trp Ser Phe Glu 
385                 390                 395                 400 


Lys Gly Gly Phe Ala Tyr Lys 
                405         


<210>  12
<211>  388
<212>  PRT
<213>  Pichia kudriavzevii

<400>  12

Met Val Ser Pro Ala Glu Arg Leu Ser Thr Ile Ala Ser Thr Ile Lys 
1               5                   10                  15      


Pro Asn Arg Lys Asp Ser Thr Ser Leu Gln Pro Glu Asp Tyr Pro Glu 
            20                  25                  30          


His Pro Phe Lys Val Thr Val Val Gly Ser Gly Asn Trp Gly Cys Thr 
        35                  40                  45              


Ile Ala Lys Val Ile Ala Glu Asn Thr Val Glu Arg Pro Arg Gln Phe 
    50                  55                  60                  


Gln Arg Asp Val Asn Met Trp Val Tyr Glu Glu Leu Ile Glu Gly Glu 
65                  70                  75                  80  


Lys Leu Thr Glu Ile Ile Asn Thr Lys His Glu Asn Val Lys Tyr Leu 
                85                  90                  95      


Pro Gly Ile Lys Leu Pro Val Asn Val Val Ala Val Pro Asp Ile Val 
            100                 105                 110         


Glu Ala Cys Ala Gly Ser Asp Leu Ile Val Phe Asn Ile Pro His Gln 
        115                 120                 125             


Phe Leu Pro Arg Ile Leu Ser Gln Leu Lys Gly Lys Val Asn Pro Lys 
    130                 135                 140                 


Ala Arg Ala Ile Ser Cys Leu Lys Gly Leu Asp Val Asn Pro Asn Gly 
145                 150                 155                 160 


Cys Lys Leu Leu Ser Thr Val Ile Thr Glu Glu Leu Gly Ile Tyr Cys 
                165                 170                 175     


Gly Ala Leu Ser Gly Ala Asn Leu Ala Pro Glu Val Ala Gln Cys Lys 
            180                 185                 190         


Trp Ser Glu Thr Thr Val Ala Tyr Thr Ile Pro Asp Asp Phe Arg Gly 
        195                 200                 205             


Lys Gly Lys Asp Ile Asp His Gln Ile Leu Lys Ser Leu Phe His Arg 
    210                 215                 220                 


Pro Tyr Phe His Val Arg Val Ile Ser Asp Val Ala Gly Ile Ser Ile 
225                 230                 235                 240 


Ala Gly Ala Leu Lys Asn Val Val Ala Met Ala Ala Gly Phe Val Glu 
                245                 250                 255     


Gly Leu Gly Trp Gly Asp Asn Ala Lys Ala Ala Val Met Arg Ile Gly 
            260                 265                 270         


Leu Val Glu Thr Ile Gln Phe Ala Lys Thr Phe Phe Asp Gly Cys His 
        275                 280                 285             


Ala Ala Thr Phe Thr His Glu Ser Ala Gly Val Ala Asp Leu Ile Thr 
    290                 295                 300                 


Thr Cys Ala Gly Gly Arg Asn Val Arg Val Gly Arg Tyr Met Ala Gln 
305                 310                 315                 320 


His Ser Val Ser Ala Thr Glu Ala Glu Glu Lys Leu Leu Asn Gly Gln 
                325                 330                 335     


Ser Cys Gln Gly Ile His Thr Thr Arg Glu Val Tyr Glu Phe Leu Ser 
            340                 345                 350         


Asn Met Gly Arg Thr Asp Glu Phe Pro Leu Phe Thr Thr Thr Tyr Arg 
        355                 360                 365             


Ile Ile Tyr Glu Asn Phe Pro Ile Glu Lys Leu Pro Glu Cys Leu Glu 
    370                 375                 380                 


Pro Val Glu Asp 
385             


<210>  13
<211>  388
<212>  PRT
<213>  Pichia kudriavzevii

<400>  13

Met Val Ser Pro Ala Glu Arg Leu Ser Thr Ile Ala Ser Thr Ile Lys 
1               5                   10                  15      


Pro Asn Arg Lys Asp Ser Thr Ser Leu Gln Pro Glu Asp Tyr Pro Glu 
            20                  25                  30          


His Pro Phe Lys Val Thr Val Val Gly Ser Gly Asn Trp Gly Cys Thr 
        35                  40                  45              


Ile Ala Lys Val Ile Ala Glu Asn Thr Val Glu Arg Pro Arg Gln Phe 
    50                  55                  60                  


Gln Arg Asp Val Asn Met Trp Val Tyr Glu Glu Leu Ile Glu Gly Glu 
65                  70                  75                  80  


Lys Leu Thr Glu Ile Ile Asn Thr Lys His Glu Asn Val Lys Tyr Leu 
                85                  90                  95      


Pro Gly Ile Lys Leu Pro Val Asn Val Val Ala Val Pro Asp Ile Val 
            100                 105                 110         


Glu Ala Cys Ala Gly Ser Asp Leu Ile Val Phe Asn Ile Pro His Gln 
        115                 120                 125             


Phe Leu Pro Arg Ile Leu Ser Gln Leu Lys Gly Lys Val Asn Pro Lys 
    130                 135                 140                 


Ala Arg Ala Ile Ser Cys Leu Lys Gly Leu Asp Val Asn Pro Asn Gly 
145                 150                 155                 160 


Cys Lys Leu Leu Ser Thr Val Ile Thr Glu Glu Leu Gly Ile Tyr Cys 
                165                 170                 175     


Gly Ala Leu Ser Gly Ala Asn Leu Ala Pro Glu Val Ala Gln Cys Lys 
            180                 185                 190         


Trp Ser Glu Thr Thr Val Ala Tyr Thr Ile Pro Asp Asp Phe Arg Gly 
        195                 200                 205             


Lys Gly Lys Asp Ile Asp His Gln Ile Leu Lys Ser Leu Phe His Arg 
    210                 215                 220                 


Pro Tyr Phe His Val Arg Val Ile Ser Asp Val Ala Gly Ile Ser Ile 
225                 230                 235                 240 


Ala Gly Ala Leu Lys Asn Val Val Ala Met Ala Ala Gly Phe Val Glu 
                245                 250                 255     


Gly Leu Gly Trp Gly Asp Asn Ala Lys Ala Ala Val Met Arg Ile Gly 
            260                 265                 270         


Leu Val Glu Thr Ile Gln Phe Ala Lys Thr Phe Phe Asp Gly Cys His 
        275                 280                 285             


Ala Ala Thr Phe Thr His Glu Ser Ala Gly Val Ala Asp Leu Ile Thr 
    290                 295                 300                 


Thr Cys Ala Gly Gly Arg Asn Val Arg Val Gly Arg Tyr Met Ala Gln 
305                 310                 315                 320 


His Ser Val Ser Ala Thr Glu Ala Glu Glu Lys Leu Leu Asn Gly Gln 
                325                 330                 335     


Ser Cys Gln Gly Ile His Thr Thr Arg Glu Val Tyr Glu Phe Leu Ser 
            340                 345                 350         


Asn Met Gly Arg Thr Asp Glu Phe Pro Leu Phe Thr Thr Thr Tyr Arg 
        355                 360                 365             


Ile Ile Tyr Glu Asn Phe Pro Ile Glu Lys Leu Pro Glu Cys Leu Glu 
    370                 375                 380                 


Pro Val Glu Asp 
385             


<210>  14
<211>  374
<212>  PRT
<213>  Pichia kudriavzevii

<400>  14

Met Ala Lys Val Asn Tyr Pro Glu Glu Phe Ala Gly Phe Ala Ile Val 
1               5                   10                  15      


Asp Thr Asn Glu Trp Asn Lys Pro Lys Tyr Ile Thr Tyr Lys Pro Lys 
            20                  25                  30          


Thr Phe Gly Asp His Asp Ile Asp Ile Glu Ile Glu Cys Cys Gly Leu 
        35                  40                  45              


Cys Gly Ser Asp Ile Met Thr Ala Arg Gly Gly Glu Ala Gly Trp Gly 
    50                  55                  60                  


Gln Ile Thr Leu Pro Gln Val Val Gly His Glu Ile Ile Gly Lys Val 
65                  70                  75                  80  


Ile Lys Val Gly Pro Lys Val Thr Leu His Arg Leu Gly Asp Arg Val 
                85                  90                  95      


Gly Leu Gly Ala Gln Ala Phe Ala Cys Leu Asp Cys Asn Arg Cys Lys 
            100                 105                 110         


Gln Asp Asn Glu Gln Tyr Cys Pro His Gly Val Thr Thr Tyr Asp Gly 
        115                 120                 125             


Lys Tyr Pro Asp Gly Tyr Val Ser Gln Gly Gly Tyr Ala Ser His Val 
    130                 135                 140                 


Arg Ala His Glu His Leu Cys Phe Pro Ile Pro Glu Lys Leu Gln Ser 
145                 150                 155                 160 


Ile His Ala Ala Ser Leu Cys Cys Ala Gly Leu Thr Val Phe Ser Pro 
                165                 170                 175     


Leu Lys Arg Tyr Ile Pro Lys Asp Leu Pro Asn Gly Val Lys Ala Lys 
            180                 185                 190         


Val Ala Ile Val Gly Leu Gly Gly Leu Gly His Leu Ala Val Gln Leu 
        195                 200                 205             


Cys Lys Ala Leu Gly Ala Glu Pro Trp Val Phe Ser Arg Gly Asn Ser 
    210                 215                 220                 


Lys Lys Glu Gln Ala Phe Lys Leu Gly Ala Ser Gly Phe Val Ala Thr 
225                 230                 235                 240 


Gly Glu Lys Asp Trp Glu Lys Pro Leu Phe Asp Gln Phe Asp Leu Ile 
                245                 250                 255     


Leu Asn Cys Ala Ile Gly Leu Ser Gly Leu Asn Leu Asp Ala Phe Ile 
            260                 265                 270         


Ser Ile Leu Lys Val Asp Gly Arg Phe Cys Ser Val Gly Leu Pro Ser 
        275                 280                 285             


Glu Ser Glu Lys Tyr Asp Val Ser Pro Phe Thr Phe Phe Ser Asn Gly 
    290                 295                 300                 


Ser Cys Leu Cys Ser Ser Ala Leu Gly Ser Arg Glu Glu Ala Leu Glu 
305                 310                 315                 320 


Leu Phe Glu Leu Ala Ala Glu Asn Asn Ile Val Pro Trp Val Glu Thr 
                325                 330                 335     


Ile Pro Ile Ser Glu Lys Gly Cys Glu Glu Ala Leu Thr Arg Ala Trp 
            340                 345                 350         


Asp Gly Asp Val Arg Tyr Arg Phe Val Phe Thr Glu Phe Asp Lys Ala 
        355                 360                 365             


Phe Gly Thr Gly Thr Ser 
    370                 


<210>  15
<211>  501
<212>  PRT
<213>  Pichia kudriavzevii

<400>  15

Met Ala Leu Pro Leu Ala Thr Thr Ile Ser Leu Ser Ser Gly Lys Thr 
1               5                   10                  15      


Leu Glu Gln Pro Ile Gly Leu Phe Ile Asp Asn Glu Phe Val Asn Pro 
            20                  25                  30          


Ile Ser Val Ser Asn Ala Arg Thr Leu Thr Thr Phe Asn Pro Ser Thr 
        35                  40                  45              


Gly Glu Pro Ile Thr Asp Val His Cys Ala Ser Ala Ala Asp Val Asp 
    50                  55                  60                  


Val Ala Val Asn Ala Ala Asn Lys Ala Met Glu Thr Trp Lys Asp Ile 
65                  70                  75                  80  


Asp Pro Thr Val Arg Val Glu Leu Leu Leu Lys Leu Ala Ser Leu Val 
                85                  90                  95      


Asp Glu His Ser Gln Ala Ile Ala Glu Ile Glu Ala Leu Asp Ser Gly 
            100                 105                 110         


Lys Pro Leu Tyr Ser Asn Ala Leu Ala Asp Val Gln Ser Val Ala Glu 
        115                 120                 125             


Tyr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Leu His Gly Thr Gln 
    130                 135                 140                 


Ile Pro Ile Asn Ser Lys Val Met Ala Ile Thr Lys Arg Val Pro Leu 
145                 150                 155                 160 


Val Val Gly Cys Ile Ile Pro Trp Asn Tyr Pro Ile Ser Met Ala Ser 
                165                 170                 175     


Trp Lys Phe Cys Pro Ala Leu Ala Ala Gly Cys Thr Ile Val Met Lys 
            180                 185                 190         


Ser Ser Glu Ile Thr Pro Leu Ser Leu Leu Tyr Phe Ala Asn Leu Val 
        195                 200                 205             


Lys Leu Ala Gly Phe Pro Lys Gly Val Phe Asn Val Val Ser Gly Phe 
    210                 215                 220                 


Gly Asp Asp Val Gly Ser Ala Leu Ser Asn His Pro Lys Leu Gly Lys 
225                 230                 235                 240 


Ile Ala Phe Thr Gly Ser Thr Leu Thr Gly Gln Lys Val Met Ala Asp 
                245                 250                 255     


Ala Ala Arg Ser Asn Leu Lys Ser Val Ser Leu Glu Cys Gly Gly Lys 
            260                 265                 270         


Ser Pro Leu Ile Val Phe Glu Asp Ala Glu Leu Asp Glu Cys Val Lys 
        275                 280                 285             


Trp Ala Ser Phe Gly Val Met Tyr Asn Thr Gly Gln Asn Cys Thr Ala 
    290                 295                 300                 


Asn Ser Arg Ile Ile Val His Asp Lys Val Tyr Asp Gln Phe Ile Glu 
305                 310                 315                 320 


Lys Phe Leu Ser Gln Leu Lys Glu Asp Trp Lys Met Gly Asp Val Met 
                325                 330                 335     


Asn Glu Lys Thr Thr Leu Gly Pro Leu Val Ser Gln Gln Gln Tyr Glu 
            340                 345                 350         


Arg Val Gln Ser Tyr Ile Asp Ile Gly Val Lys Glu Gly Ala Thr Leu 
        355                 360                 365             


Ile Gln Pro Leu Lys Glu Ser Thr Pro Ser Asn Gly Phe Tyr Ile Ser 
    370                 375                 380                 


Pro Thr Val Phe Thr Asn Val Lys Glu Asp Met Arg Ile Val Lys Glu 
385                 390                 395                 400 


Glu Ile Phe Gly Pro Val Val Thr Ile Ser Lys Phe Ser Thr Glu Glu 
                405                 410                 415     


Glu Ala Ile Ser Lys Ala Asn Asp Thr Ile Tyr Gly Leu Ala Ala Met 
            420                 425                 430         


Leu Phe Thr Thr Asn Phe Glu Arg Ala Asn Arg Val Ala Asp Lys Leu 
        435                 440                 445             


Glu Ala Gly Ser Val Tyr Ile Asn Ser Ser Asn Asn Glu Ser Thr Lys 
    450                 455                 460                 


Val Pro Phe Gly Gly Met Lys Met Ser Gly Ile Gly Arg Glu Leu Gly 
465                 470                 475                 480 


Gln Glu Ala Phe Asn Leu Tyr Thr Val Thr Lys Ser Ile Tyr Tyr Ser 
                485                 490                 495     


Tyr Gly Ala Lys Leu 
            500     


<210>  16
<211>  501
<212>  PRT
<213>  Pichia kudriavzevii

<400>  16

Met Ser Ala Leu Phe Arg Thr Ile Glu Thr Pro Asn Gly Lys Thr Leu 
1               5                   10                  15      


Glu Gln Pro Leu Gly Leu Phe Ile Asp Asn Glu Trp Val Lys Thr Asn 
            20                  25                  30          


Arg Thr Phe Glu Thr Ile Asn Pro Ser Thr Gly Glu Ala Ile Cys His 
        35                  40                  45              


Val Tyr Arg Ala Gly Val Gln Glu Val Asn Asp Ala Val Glu Ala Ala 
    50                  55                  60                  


Asn Arg Ala Phe Arg Asn Glu Ser Trp Ser Gly Leu Thr Gly Ser Gln 
65                  70                  75                  80  


Arg Gly Asp Leu Leu Tyr Arg Met Tyr Gln Val Ile Lys Arg Asp Ala 
                85                  90                  95      


Glu Ser Ile Ala Ser Ile Glu Ser Ile Asp Asn Gly Lys Pro Tyr Ala 
            100                 105                 110         


Ala Glu Cys Leu Asp Gly Asp Leu Gly Glu Ala Ala Asp Val Phe Lys 
        115                 120                 125             


Tyr Tyr Ala Gly Trp Ala Asp Lys Ile Thr Gly Glu Leu Ile Gly Ser 
    130                 135                 140                 


Ser Val Leu Gly Lys Asn Lys Met Cys Tyr Val Glu Pro Thr Pro Leu 
145                 150                 155                 160 


Gly Ala Val Gly Gly Ile Val Pro Trp Asn Phe Pro Phe Thr Met Met 
                165                 170                 175     


Ala Trp Lys Ile Ala Pro Ala Leu Ala Thr Gly Cys Thr Val Val Met 
            180                 185                 190         


Lys Ser Ser Glu Val Thr Pro Leu Thr Ala Leu Trp Tyr Gly Lys Ile 
        195                 200                 205             


Ala Leu Glu Val Gly Leu Pro Lys Gly Val Leu Asn Ile Leu Ser Gly 
    210                 215                 220                 


Phe Gly Ser Asp Val Gly Ser Ala Met Ala Ser His Pro Lys Leu Ala 
225                 230                 235                 240 


Lys Ile Ala Phe Thr Gly Ser Thr Ala Thr Gly Lys Lys Ile Met Glu 
                245                 250                 255     


Ala Ala Gly Gly Ser Asn Leu Lys Lys Val Thr Leu Glu Cys Gly Gly 
            260                 265                 270         


Lys Ser Pro Tyr Ile Val Phe Asp Asp Ala Asp Leu Glu Leu Ala Val 
        275                 280                 285             


Glu Trp Ala Tyr Trp Gly Ile Trp Tyr Asn Lys Gly Glu Val Cys Thr 
    290                 295                 300                 


Ser Thr Ser Arg Phe Leu Ile Gln Glu Asp Ile Tyr Asp Lys Phe Val 
305                 310                 315                 320 


Glu Ser Phe Val Glu Leu Thr Lys Thr Arg Ala Ile Thr Ala Asp Pro 
                325                 330                 335     


Phe Asp Asp Arg Cys Thr Ile Gly Pro Leu Val Ser Ser Ser Gln Tyr 
            340                 345                 350         


Glu Lys Val Lys Lys Tyr Val Glu Ile Gly Lys Asn Glu Gly Ala Lys 
        355                 360                 365             


Leu Leu Thr Gly Lys Phe Ile Asp Gly Pro Gly Tyr Phe Cys Glu Pro 
    370                 375                 380                 


Phe Ile Phe Ser Glu Cys Thr Asp Asp Met Thr Ile Met Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Val Gly Ile Thr Lys Phe Ser Thr Val Lys Glu 
                405                 410                 415     


Ala Ile Glu Arg Ala Asn Ala Thr Thr Tyr Gly Leu Gly Ala Ala Leu 
            420                 425                 430         


Phe Ser Ser Asn Ile Thr Lys Ala His Ser Val Ala Ala Lys Leu Glu 
        435                 440                 445             


Ala Gly Met Val Trp Ile Asn Ser Asn Gly Asp Ser Asp Ile His Ile 
    450                 455                 460                 


Pro Phe Gly Gly Ser Lys Met Ser Gly Ile Gly Arg Glu Leu Gly Pro 
465                 470                 475                 480 


Tyr Ala Leu Asp Leu Phe Thr Glu Lys Lys Ala Val His Val Asn Leu 
                485                 490                 495     


Ser Leu Pro Val Lys 
            500     


<210>  17
<211>  502
<212>  PRT
<213>  Pichia kudriavzevii

<400>  17

Met Gly Ala Thr Thr Ala Glu Ile Ser Ile Pro Asn Gly Asn Lys Tyr 
1               5                   10                  15      


Glu Gln Pro Thr Gly Leu Phe Ile Asn Gly Asp Phe Val Ala Ser Ser 
            20                  25                  30          


Asp Gly Lys Thr Ala Glu Val Glu Asn Pro Gly Asn Gly Asn Ile Val 
        35                  40                  45              


Cys Ser Val His Leu Ala Ser Ile Glu Asp Ile Asn Thr Ala Val Glu 
    50                  55                  60                  


Ala Ala Glu Asp Ala Phe Phe Lys Arg Trp Ala Thr Ile Ser Gly Lys 
65                  70                  75                  80  


Ala Lys Gly Glu Tyr Leu Ser Lys Ile Ala Asp Leu Ile Val Lys Tyr 
                85                  90                  95      


Ser Asp Gln Leu Ala Asp Leu Glu Ala Ile Glu Ser Gly Lys Pro Lys 
            100                 105                 110         


Asp Thr Asn Ala Ile Phe Asp Val Leu His Ser Ala Asp Val Phe Arg 
        115                 120                 125             


Tyr Tyr Ala Gly Lys Ala Val Thr Ala Gln Ser Gly Lys Thr Ile Glu 
    130                 135                 140                 


Ser Glu Leu Ser Lys Phe Thr Tyr Thr Val Tyr Glu Pro Tyr Gly Val 
145                 150                 155                 160 


Cys Ala Ala Ile Ile Ala Trp Asn Phe Pro Met Ser Thr Phe Ala Trp 
                165                 170                 175     


Lys Val Ala Ala Cys Leu Ala Ala Gly Asn Thr Met Val Val Lys Thr 
            180                 185                 190         


Ser Glu Leu Thr Pro Leu Ser Ala Leu Phe Met Cys Lys Ile Phe Gln 
        195                 200                 205             


Glu Ala Asp Leu Pro Ala Gly Val Ile Asn Val Thr Cys Gly Leu Gly 
    210                 215                 220                 


Ser Val Ala Gly Val Arg Leu Ser Glu His Glu Lys Val Gln Lys Ile 
225                 230                 235                 240 


Ser Phe Thr Gly Ser Thr Gly Val Gly Lys Leu Ile Gln Glu Ser Ala 
                245                 250                 255     


Ala Lys Ser Asn Leu Lys Tyr Cys Thr Leu Glu Cys Gly Gly Lys Ser 
            260                 265                 270         


Pro Leu Val Ile Tyr Glu Asp Ala Asp Leu Glu Gln Ala Val Lys Trp 
        275                 280                 285             


Ala Ala Phe Gly Ile Phe Phe Asn Lys Gly Glu Ile Cys Thr Ala Ser 
    290                 295                 300                 


Ser Arg Ile Tyr Val Gln Glu Ser Val Tyr Asp Lys Phe Leu Thr Met 
305                 310                 315                 320 


Tyr Lys Asp His Val Glu Glu Ala Tyr Val Gln Gly Glu Gln Phe Ala 
                325                 330                 335     


Thr Gly Val Asn Val Gly Pro Thr Val Cys Lys Ala Gln Gln Glu Lys 
            340                 345                 350         


Ile Leu Ala Tyr Ile Glu Ser Ala Lys Gln Glu Gly Gly Arg Ile Ile 
        355                 360                 365             


Thr Gly Gly Lys Ile Pro Ser Tyr Thr Asn Lys Asn Gly Tyr Tyr Leu 
    370                 375                 380                 


Glu Pro Thr Ile Ile Ala Asp Cys Asn Gln Asp Met Lys Val Val Arg 
385                 390                 395                 400 


Glu Glu Ile Phe Gly Pro Val Val Thr Val Ser Lys Phe Thr Ser Asp 
                405                 410                 415     


Glu Glu Ala Ile Lys Leu Ser Asn Asp Ser Glu Tyr Gly Leu Ala Ala 
            420                 425                 430         


Tyr Leu Phe Thr Lys Asp Leu Val Arg Ser Gln Asn Tyr Ile Arg Lys 
        435                 440                 445             


Val Gln Ser Gly Gln Val Phe Val Asn Phe Thr Phe Ala Ala Asp Phe 
    450                 455                 460                 


Arg Leu Pro Phe Gly Gly Tyr Lys Met Ser Gly Asn Gly Arg Glu Leu 
465                 470                 475                 480 


Gly Asp Glu Gly Leu Ser Ala Phe Gln Gln Val Lys Ala Val His Ile 
                485                 490                 495     


Asn Leu Thr Gly Lys Leu 
            500         


<210>  18
<211>  497
<212>  PRT
<213>  Pichia kudriavzevii

<400>  18

Met Ser Ala Thr Ser Val Thr Phe Pro Ile Ile Asn Glu Thr Tyr Gln 
1               5                   10                  15      


Gln Pro Thr Gly Leu Phe Ile Asn Asn Glu Phe Val Ser Ala Lys Ser 
            20                  25                  30          


Gly Lys Thr Phe Asp Val Asn Thr Pro Ile Asp Glu Ser Leu Ile Cys 
        35                  40                  45              


Lys Val Gln Gln Ala Asp Ala Glu Asp Val Glu Ile Ala Val Gln Ala 
    50                  55                  60                  


Ala Ser Lys Ala Tyr Lys Thr Trp Arg Phe Thr Pro Pro Asn Glu Arg 
65                  70                  75                  80  


Gly Arg Tyr Leu Asn Lys Leu Ala Asp Leu Met Asp Glu Lys Arg Asp 
                85                  90                  95      


Leu Leu Ala Lys Ile Glu Ser Leu Asp Asn Gly Lys Ala Leu His Cys 
            100                 105                 110         


Ala Lys Phe Asp Val Asn Leu Val Ile Glu Tyr Phe Arg Tyr Cys Ala 
        115                 120                 125             


Gly Tyr Cys Asp Lys Ile Asp Gly Arg Thr Ile Thr Thr Asp Val Glu 
    130                 135                 140                 


His Phe Thr Tyr Thr Arg Lys Glu Pro Leu Gly Val Cys Gly Ala Ile 
145                 150                 155                 160 


Thr Pro Trp Asn Phe Pro Leu Leu Met Phe Ala Trp Lys Ile Gly Pro 
                165                 170                 175     


Ala Leu Ala Thr Gly Asn Thr Ile Ile Leu Lys Pro Ala Ser Ala Thr 
            180                 185                 190         


Pro Leu Ser Asn Leu Phe Thr Cys Thr Leu Ile Lys Glu Ala Gly Ile 
        195                 200                 205             


Pro Ala Gly Val Val Asn Val Val Pro Gly Ser Gly Arg Gly Cys Gly 
    210                 215                 220                 


Asn Ser Ile Leu Gln His Pro Lys Ile Lys Lys Val Ala Phe Thr Gly 
225                 230                 235                 240 


Ser Thr Glu Val Gly Lys Thr Val Met Lys Glu Cys Ala Asn Ser Ile 
                245                 250                 255     


Lys Lys Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile Val Phe 
            260                 265                 270         


Lys Asp Cys Asn Val Glu Gln Thr Ile Gln Asn Leu Ile Thr Gly Ile 
        275                 280                 285             


Phe Phe Asn Gly Gly Glu Val Cys Cys Ala Gly Ser Arg Ile Tyr Ile 
    290                 295                 300                 


Glu Ala Thr Asp Glu Lys Trp Tyr Thr Glu Phe Leu Thr Lys Phe Lys 
305                 310                 315                 320 


Glu Thr Val Glu Lys Leu Lys Ile Gly Asn Pro Phe Glu Glu Gly Val 
                325                 330                 335     


Phe Gln Gly Ala Gln Thr Thr Pro Asp Gln Phe Gln Thr Val Leu Asp 
            340                 345                 350         


Tyr Ile Thr Ala Ala Asn Glu Ser Ser Leu Lys Leu Leu Thr Gly Gly 
        355                 360                 365             


Lys Arg Ile Gly Asn Lys Gly Tyr Phe Val Glu Pro Thr Ile Phe Tyr 
    370                 375                 380                 


Asp Val Pro Gln Asn Ser Lys Leu Thr Gln Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 


Val Ala Val Val Leu Pro Phe Lys Ser Thr Glu Glu Leu Ile Glu Lys 
                405                 410                 415     


Ala Asn Asp Ser Asp Phe Gly Leu Gly Ser Gly Ile His Thr Glu Asp 
            420                 425                 430         


Phe Asn Lys Ala Ile Trp Val Ser Glu Arg Leu Glu Ala Gly Ser Val 
        435                 440                 445             


Trp Ile Asn Thr Tyr Asn Asp Phe His Pro Ala Ala Pro Phe Gly Gly 
    450                 455                 460                 


Tyr Lys Glu Ser Gly Ile Gly Arg Glu Met Gly Ile Glu Ala Phe Asp 
465                 470                 475                 480 


Asn Tyr Thr Gln Thr Lys Leu Val Arg Ala Arg Val Asn Lys Pro Ala 
                485                 490                 495     


Phe 
    


<210>  19
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  19

Met Ser Thr Gly Val Lys Ala Asn Asp Val Lys Thr Lys Thr Lys Gly 
1               5                   10                  15      


Ala Asp Leu Val Val Asp Cys Leu Ile Ala Gln Gly Val Thr His Val 
            20                  25                  30          


Phe Gly Ile Pro Gly Ala Lys Ile Asp Ala Val Phe Asp Val Leu Gln 
        35                  40                  45              


Asp Arg Gly Pro Glu Leu Ile Val Cys Arg His Glu Gln Asn Ala Ala 
    50                  55                  60                  


Phe Met Ala Ala Ala Val Gly Arg Leu Thr Gly Lys Pro Gly Val Cys 
65                  70                  75                  80  


Leu Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly Leu Val 
                85                  90                  95      


Thr Ala Asn Ala Glu Gly Asp Pro Val Val Ala Leu Ala Gly Ala Val 
            100                 105                 110         


Pro Arg Ala Asp Arg Leu Lys Arg Thr His Gln Ser Met Asp Asn Ala 
        115                 120                 125             


Ala Leu Phe Glu Pro Ile Thr Lys Tyr Ser Val Glu Val Glu His Pro 
    130                 135                 140                 


Asp Asn Ile Pro Glu Ala Leu Thr Asn Ala Phe Arg Ala Ala Thr Ser 
145                 150                 155                 160 


Gly Asn Pro Gly Ala Ala Phe Val Ser Leu Pro Gln Asp Val Val Thr 
                165                 170                 175     


Ala Glu Thr Thr Val Lys Ser Ile Gly Ala Leu Ser Ala Pro Gln Leu 
            180                 185                 190         


Gly Pro Ala Pro Asp Glu Ala Ile Ser Ala Val Val Ala Lys Ile Lys 
        195                 200                 205             


Ser Ala Lys Leu Pro Val Ile Leu Leu Gly Met Arg Ala Ser Arg Pro 
    210                 215                 220                 


Glu Val Thr Lys Ala Val Arg Lys Leu Leu Ala Lys Thr Glu Leu Pro 
225                 230                 235                 240 


Val Val Glu Thr Tyr Gln Ala Ala Gly Ala Ile Ser Arg Glu Leu Glu 
                245                 250                 255     


Asp His Phe Phe Gly Arg Val Gly Leu Phe Arg Asn Gln Pro Gly Asp 
            260                 265                 270         


Ile Leu Leu Glu Gln Ala Asp Leu Val Ile Thr Ile Gly Tyr Asp Pro 
        275                 280                 285             


Ile Glu Tyr Asp Pro Lys Phe Trp Asn Lys Leu Gly Asp Arg Thr Ile 
    290                 295                 300                 


Ile His Leu Asp Asp Ile Gln Ala Asp Ile Asp His Asp Tyr Gln Pro 
305                 310                 315                 320 


Glu Leu Glu Leu Ile Gly Asp Ile Ala Leu Thr Val Asn Ser Ile Ala 
                325                 330                 335     


Glu Asp Leu Pro Lys Leu Val Leu Ser Ser Lys Ser Glu Glu Val Leu 
            340                 345                 350         


Glu Asp Leu Arg Ala Lys Leu Ser Glu Gln Ala Glu Val Pro Ala Arg 
        355                 360                 365             


Ala Lys Glu Gly Leu Thr His Pro Leu Gln Val Ile Arg Thr Leu Arg 
    370                 375                 380                 


Ser Leu Ile Asp Asp Asp Thr Thr Val Thr Cys Asp Ile Gly Ser His 
385                 390                 395                 400 


Ala Ile Trp Met Ala Arg Tyr Phe Arg Ser Tyr Glu Pro Arg Arg Leu 
                405                 410                 415     


Leu Phe Ser Asn Gly Met Gln Thr Leu Gly Val Ala Leu Pro Trp Ala 
            420                 425                 430         


Ile Ala Ala Thr Leu Val Asn Pro Gly Glu Lys Val Val Ser Val Ser 
        435                 440                 445             


Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala Val 
    450                 455                 460                 


Arg Leu Lys Ala Pro Ile Val His Leu Val Trp Asn Asp Gly Thr Tyr 
465                 470                 475                 480 


Asp Met Val Ala Phe Gln Gln Met Met Lys Tyr Gly Arg Thr Ser Ala 
                485                 490                 495     


Val Glu Phe Gly Asp Val Asp Ile Val Lys Tyr Ala Glu Ser Phe Gly 
            500                 505                 510         


Ala Lys Gly Leu Arg Val Asn Ser Pro Asp Glu Leu Glu Asp Val Leu 
        515                 520                 525             


Lys Ala Ala Leu Asp Ala Glu Gly Pro Val Ile Ile Asp Ile Pro Ile 
    530                 535                 540                 


Asp Tyr Arg Asp Asn Ile Lys Leu Ser Glu Lys Leu Leu Pro Asn Gln 
545                 550                 555                 560 


Phe Asn Glu Met Lys Lys Ala 
                565         


<210>  20
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  20

Met Ala Val Lys Val Tyr Tyr Asp Lys Asp Ala Asp Leu Ser Ile Ile 
1               5                   10                  15      


Gln Gly Lys Lys Val Ala Ile Ile Gly Tyr Gly Ser Gln Gly His Ala 
            20                  25                  30          


His Ala Leu Asn Leu Arg Asp Ser Gly Val Asp Val Ile Val Gly Leu 
        35                  40                  45              


Arg Glu Gly Ser Lys Ser Phe Ala Lys Ala Glu Glu Asp Gly Phe Lys 
    50                  55                  60                  


Val Phe Thr Val Ala Glu Ala Ala Lys Gln Ala Asp Val Ile Met Ile 
65                  70                  75                  80  


Leu Ala Pro Asp Glu Ile Gln Ala Asp Ile Tyr Glu Glu Glu Ile Glu 
                85                  90                  95      


Pro Asn Leu Lys Ala Gly Asn Ala Leu Phe Phe Ala His Gly Phe Asn 
            100                 105                 110         


Ile His Phe Gly Gln Ile Lys Pro Pro Ala Asp Val Asp Val Phe Met 
        115                 120                 125             


Val Ala Pro Lys Gly Pro Gly His Leu Val Arg Arg Thr Phe Val Glu 
    130                 135                 140                 


Gly Gly Gly Val Pro Cys Leu Ile Ala Val Tyr Gln Asp Ala Ser Gly 
145                 150                 155                 160 


Asn Ala Lys Asp Leu Ala Leu Ser Tyr Ala Lys Gly Ile Gly Gly Ala 
                165                 170                 175     


Arg Ala Gly Val Ile Glu Thr Thr Phe Lys Glu Glu Thr Glu Thr Asp 
            180                 185                 190         


Leu Phe Gly Glu Gln Ala Val Leu Cys Gly Gly Leu Thr Ala Leu Val 
        195                 200                 205             


Lys Ala Gly Phe Glu Thr Leu Val Glu Ala Gly Tyr Ala Pro Glu Met 
    210                 215                 220                 


Ala Tyr Phe Glu Cys Leu His Glu Leu Lys Leu Ile Val Asp Leu Met 
225                 230                 235                 240 


Tyr Glu Gly Gly Ile Ala Asn Met Arg Tyr Ser Ile Ser Asp Thr Ala 
                245                 250                 255     


Glu Tyr Gly Asp Tyr Val Ser Gly Pro Arg Val Ile Thr Ala Glu Thr 
            260                 265                 270         


Lys Glu Ala Met Lys Ala Val Leu Ala Asp Ile Gln Asp Gly Thr Phe 
        275                 280                 285             


Ala Lys Arg Phe Ile Ala Glu Asn Lys Ala Gly Arg Pro Glu Phe Asn 
    290                 295                 300                 


Ala Leu Arg Ala Lys Glu Ala Glu His Pro Ile Glu Lys Val Gly Ala 
305                 310                 315                 320 


Lys Leu Arg Asp Met Met Pro Trp Val Lys Lys Asn Lys Asp Val Asp 
                325                 330                 335     


Ala Lys Lys Asn 
            340 


<210>  21
<211>  340
<212>  PRT
<213>  Lactococcus lactis

<400>  21

Met Ala Val Thr Met Tyr Tyr Glu Asp Asp Val Glu Val Ser Ala Leu 
1               5                   10                  15      


Ala Gly Lys Gln Ile Ala Val Ile Gly Tyr Gly Ser Gln Gly His Ala 
            20                  25                  30          


His Ala Gln Asn Leu Arg Asp Ser Gly His Asn Val Ile Ile Gly Val 
        35                  40                  45              


Arg His Gly Lys Ser Phe Asp Lys Ala Lys Glu Asp Gly Phe Glu Thr 
    50                  55                  60                  


Phe Glu Val Gly Glu Ala Val Ala Lys Ala Asp Val Ile Met Val Leu 
65                  70                  75                  80  


Ala Pro Asp Glu Leu Gln Gln Ser Ile Tyr Glu Glu Asp Ile Lys Pro 
                85                  90                  95      


Asn Leu Lys Ala Gly Ser Ala Leu Gly Phe Ala His Gly Phe Asn Ile 
            100                 105                 110         


His Phe Gly Tyr Ile Lys Val Pro Glu Asp Val Asp Val Phe Met Val 
        115                 120                 125             


Ala Pro Lys Ala Pro Gly His Leu Val Arg Arg Thr Tyr Thr Glu Gly 
    130                 135                 140                 


Phe Gly Thr Pro Ala Leu Phe Val Ser His Gln Asn Ala Ser Gly His 
145                 150                 155                 160 


Ala Arg Glu Ile Ala Met Asp Trp Ala Lys Gly Ile Gly Cys Ala Arg 
                165                 170                 175     


Val Gly Ile Ile Glu Thr Thr Phe Lys Glu Glu Thr Glu Glu Asp Leu 
            180                 185                 190         


Phe Gly Glu Gln Ala Val Leu Cys Gly Gly Leu Thr Ala Leu Val Glu 
        195                 200                 205             


Ala Gly Phe Glu Thr Leu Thr Glu Ala Gly Tyr Ala Gly Glu Leu Ala 
    210                 215                 220                 


Tyr Phe Glu Val Leu His Glu Met Lys Leu Ile Val Asp Leu Met Tyr 
225                 230                 235                 240 


Glu Gly Gly Phe Thr Lys Met Arg Gln Ser Ile Ser Asn Thr Ala Glu 
                245                 250                 255     


Phe Gly Asp Tyr Val Thr Gly Pro Arg Ile Ile Thr Asp Ala Val Lys 
            260                 265                 270         


Lys Asn Met Lys Leu Val Leu Ala Asp Ile Gln Ser Gly Lys Phe Ala 
        275                 280                 285             


Gln Asp Phe Val Asp Asp Phe Lys Ala Gly Arg Pro Lys Leu Thr Ala 
    290                 295                 300                 


Tyr Arg Glu Ala Ala Lys Asn Leu Glu Ile Glu Lys Ile Gly Ala Glu 
305                 310                 315                 320 


Leu Arg Lys Ala Met Pro Phe Thr Gln Ser Gly Asp Asp Asp Ala Phe 
                325                 330                 335     


Lys Ile Tyr Gln 
            340 


<210>  22
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  22

Met Pro Lys Tyr Arg Ser Arg Thr Ile Thr His Gly Arg Asn Met Ala 
1               5                   10                  15      


Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Met Lys Asp Glu Asp Phe 
            20                  25                  30          


Gly Lys Pro Ile Ile Ala Val Ala Asn Ser Phe Thr Gln Phe Val Pro 
        35                  40                  45              


Gly His Val His Leu Lys Asp Leu Gly Gln Leu Val Lys Glu Glu Ile 
    50                  55                  60                  


Glu Ala Ala Gly Gly Val Pro Lys Glu Phe Asn Thr Ile Ala Val Asp 
65                  70                  75                  80  


Asp Gly Ile Ala Met Gly His Asp Gly Met Leu Tyr Ser Leu Pro Ser 
                85                  90                  95      


Arg Glu Ile Ile Ala Asp Ser Val Glu Tyr Met Val Asn Ala His Cys 
            100                 105                 110         


Ala Asp Ala Met Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly 
        115                 120                 125             


Met Leu Met Ala Ala Ala Arg Leu Asn Ile Pro Ala Val Phe Val Ser 
    130                 135                 140                 


Gly Gly Pro Met Glu Ala Gly Lys Thr Lys Leu Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Lys Leu Asp Leu Phe Glu Ala Met Gly Ala Ala Ala Asp Gly Lys Ile 
                165                 170                 175     


Ser Asp Glu Asp Val Ala Gln Ile Glu Arg Ser Ala Cys Pro Thr Cys 
            180                 185                 190         


Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Leu Thr 
        195                 200                 205             


Glu Ala Leu Gly Leu Ser Leu Pro Gly Asn Gly Ser Ile Leu Ala Thr 
    210                 215                 220                 


His Ala Asp Arg Lys Glu Leu Phe Arg Glu Ala Gly Arg Ala Ile Val 
225                 230                 235                 240 


Glu Leu Ala Lys Arg Tyr Tyr Glu Gln Asp Asp Lys Ser Ile Leu Pro 
                245                 250                 255     


Arg Asp Ile Ala Thr Lys Glu Ala Phe Glu Asn Ala Met Ala Leu Asp 
            260                 265                 270         


Met Ala Met Gly Gly Ser Thr Asn Thr Val Leu His Leu Leu Ala Ile 
        275                 280                 285             


Ala Gln Glu Ala Glu Val Asp Phe Thr Leu Asp Asp Ile Asp Arg Ile 
    290                 295                 300                 


Ser Arg Arg Val Pro His Leu Cys Lys Val Ala Pro Ser Gly Gln Lys 
305                 310                 315                 320 


Tyr His Met Glu Asp Val His Arg Ala Gly Gly Ile Pro Ala Ile Leu 
                325                 330                 335     


Gly Glu Leu Leu Arg Ala Gly Leu Leu His Gly Asp Cys Leu Thr Val 
            340                 345                 350         


Thr Gly Lys Thr Leu Ala Glu Asn Leu Ala Asp Trp Asp Ile Pro Pro 
        355                 360                 365             


Thr Gln Asp Glu Ala Val Gln Glu Phe Phe Arg Ala Ala Pro Gly Gly 
    370                 375                 380                 


Ile Arg Thr Gln Lys Ala Phe Ser Gln Ser Cys Arg Trp Asp Thr Leu 
385                 390                 395                 400 


Asp Leu Asp Arg Asp Glu Gly Val Ile Arg Pro Leu Glu Asn Ala Phe 
                405                 410                 415     


Ser Lys Asp Gly Gly Leu Ala Val Leu Lys Gly Asn Leu Ala Pro Asp 
            420                 425                 430         


Gly Cys Val Val Lys Thr Ala Gly Val Asp Glu Ser Ile Leu Lys Phe 
        435                 440                 445             


Thr Gly Pro Ala Arg Val Phe Glu Ser Gln Asp Glu Ala Val Glu Ala 
    450                 455                 460                 


Ile Leu Asn Gly Lys Val Lys Ala Gly Asp Val Val Val Ile Arg Tyr 
465                 470                 475                 480 


Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu Tyr Pro Thr 
                485                 490                 495     


Ser Tyr Leu Lys Gly Lys Gly Leu Gly Lys Asp Cys Ala Leu Ile Thr 
            500                 505                 510         


Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile Gly His Val 
        515                 520                 525             


Ser Pro Glu Ala Ala Glu Gly Gly Pro Ile Ala Leu Val Glu Asp Gly 
    530                 535                 540                 


Asp Arg Ile Thr Ile Asp Ile Pro Asn Arg Ser Ile Asp Leu Leu Val 
545                 550                 555                 560 


Ser Asp Glu Glu Leu Ala Ala Arg Arg Ala Ala Trp Lys Pro Pro Pro 
                565                 570                 575     


Arg Pro Arg Tyr Val Ser Gly Ala Leu Lys Ala Tyr Ala Lys Leu Val 
            580                 585                 590         


Thr Ser Ala Asp Lys Gly Ala Val Arg Asp Leu Ser Lys Leu 
        595                 600                 605     


<210>  23
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  23

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Ile Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Ile 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Asp Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Glu Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Glu Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Val Val Ile Ala Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ala Val Asp Glu Glu Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Glu Ser Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Val Ile Glu Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Val Ser Ser Leu Ser Asp Leu Ser Gly Ile Glu Tyr Glu 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Ile Pro Ser Asp Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Asn Ile Phe Leu Lys Ser Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Leu Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Val Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Val Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Leu Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys 
545         


<210>  24
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  24

Met Ser Glu Ser Gln Val Ala Val Leu Pro Asn Val Gln Gln Phe Leu 
1               5                   10                  15      


Asp Arg Gln His Gly Leu Tyr Ile Asp Gly Arg Gln Val Ala Ser Gln 
            20                  25                  30          


Ser Glu Lys Arg Leu Pro Val Phe Asn Pro Ala Thr Gly Gln Ala Ile 
        35                  40                  45              


Ala Ser Thr Ala Asp Ala Ser Glu Ala Asp Val Asp Arg Ala Val Met 
    50                  55                  60                  


Ser Ala Trp Arg Ala Phe Val Asp Arg Arg Trp Ala Gly Arg Leu Pro 
65                  70                  75                  80  


Ala Glu Arg Glu Arg Ile Leu Leu Arg Phe Ala Asp Leu Val Glu Gln 
                85                  90                  95      


His Ala Glu Glu Leu Ala Gln Leu Glu Thr Leu Glu Gln Gly Lys Ser 
            100                 105                 110         


Ile Ala Ile Ser Arg Ala Phe Glu Val Gly Cys Thr Leu Asn Trp Met 
        115                 120                 125             


Arg Tyr Thr Ala Gly Leu Thr Thr Lys Ile Ala Gly Lys Thr Leu Asp 
    130                 135                 140                 


Leu Ser Ile Pro Leu Pro Pro Gly Ala Arg Tyr Gln Ala Trp Thr Arg 
145                 150                 155                 160 


Lys Glu Pro Val Gly Val Val Ala Gly Ile Val Pro Trp Asn Phe Pro 
                165                 170                 175     


Leu Met Ile Gly Met Trp Lys Val Met Pro Ala Leu Ala Ala Gly Cys 
            180                 185                 190         


Ser Ile Val Ile Lys Pro Ser Glu Thr Thr Pro Leu Thr Leu Leu Arg 
        195                 200                 205             


Val Ala Glu Leu Ala Ser Glu Ala Gly Ile Pro Asp Gly Val Phe Asn 
    210                 215                 220                 


Val Val Thr Gly Ser Gly Ala Val Cys Gly Ala Ala Leu Thr Ser His 
225                 230                 235                 240 


Pro His Val Ala Lys Val Ser Phe Thr Gly Ser Thr Ala Thr Gly Lys 
                245                 250                 255     


Gln Ile Ala Arg Thr Ala Ala Asp Arg Leu Thr Arg Val Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Asn Pro Ala Ile Val Leu Lys Asp Ala Asp Pro Gln 
        275                 280                 285             


Trp Val Ile Glu Gly Leu Met Met Gly Ser Phe Leu Asn Gln Gly Gln 
    290                 295                 300                 


Val Cys Ala Ala Ser Ser Arg Ile Tyr Ile Glu Ala Pro Leu Phe Asp 
305                 310                 315                 320 


Thr Leu Val Ala Gly Phe Glu Gln Ala Val Lys Ser Leu Ser Val Gly 
                325                 330                 335     


Pro Gly Met Ser Pro Thr Ala Gln Ile Asn Pro Leu Val Ser Arg Ala 
            340                 345                 350         


His Cys Asp Lys Val Ala Ala Phe Leu Asp Asp Ala Gln Ala Gln Gly 
        355                 360                 365             


Ala Glu Leu Ile Arg Gly Ala Ala Gly Pro Ala Gly Gln Gly Tyr Tyr 
    370                 375                 380                 


Val Ser Pro Thr Leu Val Val Asn Pro Asp Ala Gly Leu Arg Leu Thr 
385                 390                 395                 400 


Arg Glu Glu Val Phe Gly Pro Val Val Asn Leu Val Arg Val Ala Asp 
                405                 410                 415     


Gly Glu Glu Ala Leu Arg Leu Ala Asn Asp Thr Asp Tyr Gly Leu Thr 
            420                 425                 430         


Ala Ser Val Trp Thr Gln Asp Leu Ser Gln Ala Leu Glu Tyr Thr Asp 
        435                 440                 445             


Arg Leu Gln Ala Gly Thr Val Trp Val Asn Ser His Thr Leu Ile Asp 
    450                 455                 460                 


Ala Asn Leu Pro Phe Gly Gly Met Lys Gln Ser Gly Thr Gly Arg Asp 
465                 470                 475                 480 


Phe Gly Pro Asp Trp Leu Asp Gly Trp Cys Glu Thr Lys Ser Val Cys 
                485                 490                 495     


Val Arg Tyr 
            


