<110>    Korea Research Institute of Bioscience and Biotechnology

<120>    PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MUSCULAR
         DISEASE OR CACHEXIA COMPRISING, AS ACTIVE INGREDIENT, miRNA
         LOCATED IN Dlk1-Dio3 CLUSTER OR VARIANT THEREOF

<130>    PCB811123KBB/PCT

<150>    KR 10-2018-0002557
<151>    2018-01-09

<160>    67

<170>    KoPatentIn 3.0

<210>    1
<211>    66
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-668


<400>    1
ggtaagtgcg cctcgggtga gcatgcactt aatgtgggtg tatgtcactc ggctcggccc         60

actacc                                                                    66


<210>    2
<211>    66
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-376c


<400>    2
aaaaggtgga tattccttct atgtttatgt tatttatggt taaacataga ggaaattcca         60

cgtttt                                                                    66


<210>    3
<211>    68
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-376a


<400>    3
taaaaggtag attctccttc tatgagtaca ttatttatga ttaatcatag aggaaaatcc         60

acgttttc                                                                  68


<210>    4
<211>    81
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-494


<400>    4
gatactcgaa ggagaggttg tccgtgttgt cttctcttta tttatgatga aacatacacg         60

ggaaacctct tttttagtat c                                                   81


<210>    5
<211>    84
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-541


<400>    5
acgtcaggga aaggattctg ctgtcggtcc cactccaaag ttcacagaat gggtggtggg         60

cacagaatct ggactctgct tgtg                                                84


<210>    6
<211>    88
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-1197


<400>    6
acttcctggt atttgaagat gcggttgacc atggtgtgta cgctttattt gtgacgtagg         60

acacatggtc tacttcttct caatatca                                            88


<210>    7
<211>    82
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-495


<400>    7
tggtacctga aaagaagttg cccatgttat tttcgcttta tatgtgacga aacaaacatg         60

gtgcacttct ttttcggtat ca                                                  82


<210>    8
<211>    76
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-382


<400>    8
tacttgaaga gaagttgttc gtggtggatt cgctttactt atgacgaatc attcacggac         60

aacacttttt tcagta                                                         76


<210>    9
<211>    91
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-412


<400>    9
ctggggtacg gggatggatg gtcgaccagt tggaaagtaa ttgtttctaa tgtacttcac         60

ctggtccact agccgtccgt atccgctgca g                                        91


<210>    10
<211>    69
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-377


<400>    10
ttgagcagag gttgcccttg gtgaattcgc tttatttatg ttgaatcaca caaaggcaac         60

ttttgtttg                                                                 69


<210>    11
<211>    80
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-329


<400>    11
ggtacctgaa gagaggtttt ctgggtttct gtttctttaa tgaggacgaa acacacctgg         60

ttaacctctt ttccagtatc                                                     80


<210>    12
<211>    88
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-758


<400>    12
gcctggatac atgagatggt tgaccagaga gcacacgctt tatttgtgcc gtttgtgacc         60

tggtccacta accctcagta tctaatgc                                            88


<210>    13
<211>    61
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-380


<400>    13
aagatggttg accatagaac atgcgctatc tctgtgtcgt atgtaatatg gtccacatct         60

t                                                                         61


<210>    14
<211>    83
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-300


<400>    14
tgctacttga agagaggtaa tccttcacgc atttgcttta cttgcaatga ttatacaagg         60

gcagactctc tctggggagc aaa                                                 83


<210>    15
<211>    63
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-299


<400>    15
aagaaatggt ttaccgtccc acatacattt tgaatatgta tgtgggatgg taaaccgctt         60

ctt                                                                       63


<210>    16
<211>    79
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-409


<400>    16
tggtactcgg ggagaggtta cccgagcaac tttgcatctg gacgacgaat gttgctcggt         60

gaaccccttt tcggtatca                                                      79


<210>    17
<211>    73
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-134


<400>    17
cagggtgtgt gactggttga ccagaggggc atgcactgtg ttcaccctgt gggccaccta         60

gtcaccaacc ctc                                                            73


<210>    18
<211>    91
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-544a


<400>    18
attttcatca cctagggatc ttgttaaaaa gcagattctg attcagggac caagattctg         60

catttttagc aagttctcaa gtgatgctaa t                                        91


<210>    19
<211>    67
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-379


<400>    19
agagatggta gactatggaa cgtaggcgtt atgatttctg acctatgtaa catggtccac         60

taactct                                                                   67


<210>    20
<211>    94
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-432


<400>    20
tgactcctcc aggtcttgga gtaggtcatt gggtggatcc tctatttcct tacgtgggcc         60

actggatggc tcctccatgt cttggagtag atca                                     94


<210>    21
<211>    89
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-493


<400>    21
ctggcctcca gggctttgta catggtaggc tttcattcat tcgtttgcac attcggtgaa         60

ggtctactgt gtgccaggcc ctgtgccag                                           89


<210>    22
<211>    82
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-136


<400>    22
tgagccctcg gaggactcca tttgttttga tgatggattc ttatgctcca tcatcgtctc         60

aaatgagtct tcagagggtt ct                                                  82


<210>    23
<211>    114
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-431


<400>    23
tcctgcttgt cctgcgaggt gtcttgcagg ccgtcatgca ggccacactg acggtaacgt         60

tgcaggtcgt cttgcagggc ttctcgcaag acgacatcct catcaccaac gacg              114


<210>    24
<211>    84
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-487b


<400>    24
ttggtacttg gagagtggtt atccctgtcc tgttcgtttt gctcatgtcg aatcgtacag         60

ggtcatccac tttttcagta tcaa                                                84


<210>    25
<211>    100
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-376b


<400>    25
cagtccttct ttggtattta aaacgtggat attccttcta tgtttacgtg attcctggtt         60

aatcatagag gaaaatccat gttttcagta tcaaatgctg                              100


<210>    26
<211>    72
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-665


<400>    26
tctcctcgag gggtctctgc ctctacccag gactctttca tgaccaggag gctgaggccc         60

ctcacaggcg gc                                                             72


<210>    27
<211>    81
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-654


<400>    27
gggtaagtgg aaagatggtg ggccgcagaa catgtgctga gttcgtgcca tatgtctgct         60

gaccatcacc tttagaagcc c                                                   81


<210>    28
<211>    75
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-370


<400>    28
agacagagaa gccaggtcac gtctctgcag ttacacagct cacgagtgcc tgctggggtg         60

gaacctggtc tgtct                                                          75


<210>    29
<211>    86
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-323a


<400>    29
ttggtacttg gagagaggtg gtccgtggcg cgttcgcttt atttatggcg cacattacac         60

ggtcgacctc tttgcagtat ctaatc                                              86


<210>    30
<211>    78
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-543


<400>    30
tacttaatga gaagttgccc gtgttttttt cgctttattt gtgacgaaac attcgcggtg         60

cacttctttt tcagtatc                                                       78


<210>    31
<211>    102
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-496


<400>    31
cccaagtcag gtactcgaat ggaggttgtc catggtgtgt tcattttatt tatgatgagt         60

attacatggc caatctcctt tcggtactca attcttcttg gg                           102


<210>    32
<211>    78
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-539


<400>    32
atacttgagg agaaattatc cttggtgtgt tcgctttatt tatgatgaat catacaagga         60

caatttcttt ttgagtat                                                       78


<210>    33
<211>    75
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-381


<400>    33
tacttaaagc gaggttgccc tttgtatatt cggtttattg acatggaata tacaagggca         60

agctctctgt gagta                                                          75


<210>    34
<211>    84
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-154


<400>    34
gtggtacttg aagataggtt atccgtgttg ccttcgcttt atttgtgacg aatcatacac         60

ggttgaccta tttttcagta ccaa                                                84


<210>    35
<211>    78
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-1193


<400>    35
gtagctgagg ggatggtaga ccggtgacgt gcacttcatt tacgatgtag gtcacccgtt         60

tgactatcca ccagcgcc                                                       78


<210>    36
<211>    93
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-337


<400>    36
gtagtcagta gttggggggt gggaacggct tcatacagga gttgatgcac agttatccag         60

ctcctatatg atgcctttct tcatcccctt caa                                      93


<210>    37
<211>    70
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-369


<400>    37
ttgaagggag atcgaccgtg ttatattcgc tttattgact tcgaataata catggttgat         60

cttttctcag                                                                70


<210>    38
<211>    93
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-433


<400>    38
ccggggagaa gtacggtgag cctgtcatta ttcagagagg ctagatcctc tgtgttgaga         60

aggatcatga tgggctcctc ggtgttctcc agg                                      93


<210>    39
<211>    94
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-434


<400>    39
tcgactctgg gtttgaacca aagctcgact catggtttga accattactt aattcgtggt         60

ttgaaccatc actcgactcc tggttcgaac catc                                     94


<210>    40
<211>    73
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-485


<400>    40
acttggagag aggctggccg tgatgaattc gattcatcaa agcgagtcat acacggctct         60

cctctctttt agt                                                            73


<210>    41
<211>    80
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-410


<400>    41
ggtacctgag aagaggttgt ctgtgatgag ttcgctttta ttaatgacga atataacaca         60

gatggcctgt tttcagtacc                                                     80


<210>    42
<211>    96
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-411


<400>    42
tggtacttgg agagatagta gaccgtatag cgtacgcttt atctgtgacg tatgtaacac         60

ggtccactaa ccctcagtat caaatccatc cccgag                                   96


<210>    43
<211>    97
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    miRNA-127


<400>    43
tgtgatcact gtctccagcc tgctgaagct cagagggctc tgattcagaa agatcatcgg         60

atccgtctga gcttggctgg tcggaagtct catcatc                                  97


<210>    44
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mouse atrogin-1 forward primer


<400>    44
acaagggaag tacgaaggag cg                                                  22


<210>    45
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mouse atrogin-1 reverse primer


<400>    45
ggcagtcgag aagtccagtc                                                     20


<210>    46
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mouse beta-actin forward primer


<400>    46
ggctgtattc ccctccat                                                       18


<210>    47
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mouse beta-actin reverse primer


<400>    47
ccagttggta acaatgccat g                                                   21


<210>    48
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    human atrogin-1 forward primer


<400>    48
ccatccgtct agtccgctc                                                      19


<210>    49
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    human atrogin-1 reverse primer


<400>    49
tgaggtcgct cacgaaactg                                                     20


<210>    50
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    human GAPDH forward primer


<400>    50
tgttgccatc aatgaccc                                                       18


<210>    51
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    human GAPDH reverse primer


<400>    51
cccacgacgt actcagcg                                                       18


<210>    52
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mmu-miR-376c primer


<400>    52
aacatagagg aaatttcacg t                                                   21


<210>    53
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    U6 primer


<400>    53
tggcccctgc gcaaggatg                                                      19


<210>    54
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    atrogin-1 forward primer


<400>    54
cagcttcgtg agcgacctc                                                      19


<210>    55
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    atrogin-1 reverse primer


<400>    55
ggcagtcgag aagtccagtc                                                     20


<210>    56
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    GAPDH forward primer


<400>    56
gggaaattca acggcacagt                                                     20


<210>    57
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    GAPDH reverse primer


<400>    57
agatggtgat gggcttccc                                                      19


<210>    58
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Luciferase 2 forward primer


<400>    58
caccttcgtg acttcccatt                                                     20


<210>    59
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Luciferase 2 reverse primer


<400>    59
tgactgaatc ggacacaagc                                                     20


<210>    60
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    5'biotinylated ASO for endogenous Atrogin-1 primer


<400>    60
atgtggcact cacagcagag                                                     20


<210>    61
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    5'biotinylated ASO for reporter mRNA primer


<400>    61
agacgggcaa gaaagaggat                                                     20


<210>    62
<211>    19
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Atrogin-1 Cat. No. 1357211 sense sequence


<400>    62
gauagaugug uucgucuua                                                      19


<210>    63
<211>    19
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Atrogin-1 Cat. No. 1357211 antisense sequence


<400>    63
uaagacgaac acaucuauc                                                      19


<210>    64
<211>    19
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Atrogin-1 Cat. No. 1357212 sense sequence


<400>    64
gugaucuaag augggaagg                                                      19


<210>    65
<211>    19
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Atrogin-1 Cat. No. 1357212 antisense sequence


<400>    65
ccuucccauc uuagaucac                                                      19


<210>    66
<211>    19
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Atrogin-1 Cat. No. 1357210 sense sequence


<400>    66
agagagucgg caagucugu                                                      19


<210>    67
<211>    19
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Atrogin-1 Cat. No. 1357210 antisense sequence


<400>    67
acagacuugc cgacucucu                                                      19
