                         SEQUENCE LISTING

<110>  CUROCELL CO. LTD.
       KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
 
<120>  ENHANCED IMMUNE CELLS USING DUAL SHRNA AND COMPOSITION INCLUDING 
       THE SAME

<130>  14570-001-228

<140>  To Be Assigned
<141>  Herewith

<150>  KR 10-2018-0004238
<151>  2018-01-12

<160>  289   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target GFP for RNA 
       interference

<400>  1
tctcggcatg gacgagctgt a                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  2
tggaacccat tcctgaaatt a                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  3
ggaacccatt cctgaaatta t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  4
gaacccattc ctgaaattat t                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  5
acccattcct gaaattattt a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  6
cccattcctg aaattattta a                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  7
ccttccctgt ggttctatta t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  8
cttccctgtg gttctattat a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  9
ttccctgtgg ttctattata t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  10
tccctgtggt tctattatat t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  11
ccctgtggtt ctattatatt a                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-1 for RNA 
       interference

<400>  12
cctgtggttc tattatatta t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  13
gatgaaaggg atgtgaatta t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  14
gggagcctcc ctgatataaa t                                                 21


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  15
ggaattcgct cagaagaaa                                                    19


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  16
ggaccaaact gaagctatat t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  17
agaactttgg tttcctttaa t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  18
atgaaaggga tgtgaattat t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  19
tcttatcttc ggcgctttaa t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  20
cttatcttcg gcgctttaat t                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  21
ttatcttcgg cgctttaatt t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  22
gaggagccca atgagtatta t                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  23
aggagcccaa tgagtattat t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  24
atagatccaa ccaccttatt t                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  25
atgtcattgc ctctgtattt a                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  26
tgtcattgcc tctgtattta a                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  27
accaccatgc ccagctaatt t                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  28
tgttgagatt taggcttatt t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  29
gaccaaactg aagctatatt t                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  30
aggccttcag caatctatat t                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  31
ggccttcagc aatctatatt a                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  32
gagtggtccc taaacttaaa t                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  33
agtggtccct aaacttaaat t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  34
gtggtcccta aacttaaatt t                                                 21


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIM-3 for RNA
       interference

<400>  35
ctaacacaaa tatccacat                                                    19


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAG-3 for RNA
       interference

<400>  36
tcagcagccc agtccaaata a                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAG-3 for RNA
       interference

<400>  37
cagcagccca gtccaaataa a                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAG-3 for RNA
       interference

<400>  38
tcaacgtctc catcatgtat a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAG-3 for RNA
       interference

<400>  39
caacgtctcc atcatgtata a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAG-3 for RNA
       interference

<400>  40
ctggagacaa tggcgacttt a                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAG-3 for RNA
       interference

<400>  41
ctcagcagcc cagtccaaat a                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAG-3 for RNA
       interference

<400>  42
agcagcccag tccaaataaa c                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  43
gggatcaaag ctatctatat a                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  44
ggatcaaagc tatctatata a                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  45
ggcaacggaa cccagattta t                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  46
tgaagaagag agtccatatt t                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  47
ttggatgcgg aacccaaatt a                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  48
agcatcactt gggattaata t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  49
tgatgtgggt caaggaatta a                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  50
agcgagggag aagactatat t                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CTLA-4 for 
       RNA interference

<400>  51
tttacgtatg agacgtttat a                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target BTLA for RNA 
       interference

<400>  52
gctcctgtat agtttacttc c                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target BTLA for RNA 
       interference

<400>  53
ggaaattaac ctggttgatg c                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target BTLA for RNA 
       interference

<400>  54
gcaccaacag aatatgcatc c                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target BTLA for RNA 
       interference

<400>  55
gctcaacagg atgtcaaata a                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target BTLA for RNA 
       interference

<400>  56
gcatcttgct gttcttctta c                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target BTLA for RNA 
       interference

<400>  57
gcatttgtgg acaacttatg t                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD160 for RNA
       interference

<400>  58
ggaacgcgac taaacttaat c                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD160 for RNA
       interference

<400>  59
gatgttcacc ataagccaag t                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD160 for RNA
       interference

<400>  60
gcaagatgag tctgactatg g                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD160 for RNA
       interference

<400>  61
ggcacagaga agaatgcaac a                                                 21


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD160 for RNA
       interference

<400>  62
gggaagagat gctaaatata c                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD160 for RNA
       interference

<400>  63
gcaaatcagt gtaatccttg a                                                 21


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target VISTA for RNA
       interference

<400>  64
gcaacttctc catcaccatg c                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target VISTA for RNA
       interference

<400>  65
gcaaagatgc accatccaac t                                                 21


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target VISTA for RNA
       interference

<400>  66
gcggatggac agcaacattc a                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target VISTA for RNA
       interference

<400>  67
ggacacttct gagtatgaag c                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target VISTA for RNA
       interference

<400>  68
gggaaccaca atgcacgaaa g                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target VISTA for RNA
       interference

<400>  69
ggtgctttcc aacacacttt c                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIGIT for RNA
       interference

<400>  70
gcttctggcc atttgtaatg c                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIGIT for RNA
       interference

<400>  71
gggagtactt ctgcatctat c                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIGIT for RNA
       interference

<400>  72
gctgcatgac tacttcaatg t                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIGIT for RNA
       interference

<400>  73
taacgtggat cttgatcata a                                                 21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIGIT for RNA
       interference

<400>  74
ggagacatac acaggccttc a                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TIGIT for RNA
       interference

<400>  75
gcatttgggc cttgatctac c                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target 2B4 for RNA 
       interference

<400>  76
gacaggttgc aaggcagttc t                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target 2B4 for RNA 
       interference

<400>  77
gggagtgcct cttcagttac a                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target 2B4 for RNA 
       interference

<400>  78
ggacgaggag gttgacatta a                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target 2B4 for RNA 
       interference

<400>  79
gaggagaaag aggaaggaga a                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target 2B4 for RNA 
       interference

<400>  80
gcccttcctt caatagcact a                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target 2B4 for RNA 
       interference

<400>  81
ggttgactgc atttctagac t                                                 21


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-L1 for RNA
       interference

<400>  82
gcatttgctg aacgcattta c                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-L1 for RNA
       interference

<400>  83
gctgcactaa ttgtctattg g                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-L1 for RNA
       interference

<400>  84
ggatccagtc acctctgaac a                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-L1 for RNA
       interference

<400>  85
gcacatcctc caaatgaaag g                                                 21


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-L1 for RNA
       interference

<400>  86
ggattctcaa cctgtggttt a                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PD-L1 for RNA
       interference

<400>  87
ggtgcttggt ctcctctata a                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-1 for 
       RNA interference

<400>  88
gcacagtact cctggcttat c                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-1 for 
       RNA interference

<400>  89
gcaacaggac cacagtcaag a                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-1 for 
       RNA interference

<400>  90
gcaacaccac cctcagcata a                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-1 for 
       RNA interference

<400>  91
gcctgttcag agcactcatt c                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-1 for 
       RNA interference

<400>  92
gcagtaatgc cttctcctat t                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-1 for 
       RNA interference

<400>  93
gcaccttggt gcttagctag a                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-3 for 
       RNA interference

<400>  94
gcttccatct atgaggaatt g                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-3 for 
       RNA interference

<400>  95
gccagagaac cagctataag t                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-3 for 
       RNA interference

<400>  96
gggtccctga tgaatatctg g                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-3 for 
       RNA interference

<400>  97
ggcttgcagg gaaagtgaat g                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-3 for 
       RNA interference

<400>  98
gcttgcaggg aaagtgaatg g                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-3 for 
       RNA interference

<400>  99
agcttccatc tatgaggaat t                                                 21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-5 for 
       RNA interference

<400>  100
ggaatccaga acgaattaag t                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-5 for 
       RNA interference

<400>  101
ggctgattga tgggaacatc c                                                 21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-5 for 
       RNA interference

<400>  102
ggactacagt caagacaatc a                                                 21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-5 for 
       RNA interference

<400>  103
ggaccctcac tctattcaat g                                                 21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-5 for 
       RNA interference

<400>  104
gctactggcc gcaataattc c                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CEACAM-5 for 
       RNA interference

<400>  105
gctctttgta tgacagaata c                                                 21


<210>  106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD96 for RNA 
       interference

<400>  106
ggtccaaggt caccaataag a                                                 21


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD96 for RNA 
       interference

<400>  107
gcaaccatac gatagaaata g                                                 21


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD96 for RNA 
       interference

<400>  108
ggttctgaaa tttcctcaac a                                                 21


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD96 for RNA 
       interference

<400>  109
gcaagatatc cagctacatc t                                                 21


<210>  110
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD96 for RNA 
       interference

<400>  110
gcaactcacc ctcttccatc t                                                 21


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD96 for RNA 
       interference

<400>  111
gctgcattcc ctaagataat t                                                 21


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAIR1 for RNA
       interference

<400>  112
gggacagtag atccacatac a                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAIR1 for RNA
       interference

<400>  113
ggacaacagt cacaatgagc a                                                 21


<210>  114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAIR1 for RNA
       interference

<400>  114
ggctgttgat gttctagaga g                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAIR1 for RNA
       interference

<400>  115
gcagacaagg ccacagtcaa t                                                 21


<210>  116
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAIR1 for RNA
       interference

<400>  116
ggaggtttct aaccagcatc c                                                 21


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LAIR1 for RNA
       interference

<400>  117
gccttgagac tgtgctatac a                                                 21


<210>  118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target KLRG1 for RNA
       interference

<400>  118
ccaagcccag aatgactatg g                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target KLRG1 for RNA
       interference

<400>  119
gccttcttgt tcttgccttg t                                                 21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target KLRG1 for RNA
       interference

<400>  120
gcttctgact gcagttcttc t                                                 21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target KLRG1 for RNA
       interference

<400>  121
gctggatgaa atatggtaac c                                                 21


<210>  122
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target KLRG1 for RNA
       interference

<400>  122
ggaaatgagc ctgctccaag t                                                 21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target KLRG1 for RNA
       interference

<400>  123
ggattggtct gaggaacaat t                                                 21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target FAS for RNA 
       interference

<400>  124
gccaagaagg gaaggagtac a                                                 21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target FAS for RNA 
       interference

<400>  125
gccaattcca ctaattgttt g                                                 21


<210>  126
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target FAS for RNA 
       interference

<400>  126
ggttctcatg aatctccaac t                                                 21


<210>  127
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target FAS for RNA 
       interference

<400>  127
gctggagtca tgacactaag t                                                 21


<210>  128
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target FAS for RNA 
       interference

<400>  128
gcctggtttg gagatactaa c                                                 21


<210>  129
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target FAS for RNA 
       interference

<400>  129
ggaaccacct aaagaacttc c                                                 21


<210>  130
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-b for RNA
       interference

<400>  130
ccgcgttgat ttaaagaaag a                                                 21


<210>  131
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-b for RNA
       interference

<400>  131
gcctgataca tatcagcatt t                                                 21


<210>  132
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-b for RNA
       interference

<400>  132
gcggaattgg aatttcttag c                                                 21


<210>  133
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-b for RNA
       interference

<400>  133
gcacgactac agaaatatag c                                                 21


<210>  134
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-b for RNA
       interference

<400>  134
tttccggtta agttgcactc g                                                 21


<210>  135
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-b for RNA
       interference

<400>  135
gcctggatct aattcagaaa g                                                 21


<210>  136
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LRR1 for RNA 
       interference

<400>  136
gaaagccact gttcggttaa a                                                 21


<210>  137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LRR1 for RNA 
       interference

<400>  137
tcctgtggat atctgtctaa g                                                 21


<210>  138
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LRR1 for RNA 
       interference

<400>  138
ggctcataga ggctgtaatg t                                                 21


<210>  139
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LRR1 for RNA 
       interference

<400>  139
gggcttgtcc gagttgatat g                                                 21


<210>  140
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LRR1 for RNA 
       interference

<400>  140
aagatttgga taccgcaaaa a                                                 21


<210>  141
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target LRR1 for RNA 
       interference

<400>  141
gtggtactga agcacctatt a                                                 21


<210>  142
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TGFBR1 for 
       RNA interference

<400>  142
gcttgttcag agaacaattg c                                                 21


<210>  143
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TGFBR1 for 
       RNA interference

<400>  143
ggagattgtt ggtacccaag g                                                 21


<210>  144
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TGFBR1 for 
       RNA interference

<400>  144
gcagctaggc ttacagcatt g                                                 21


<210>  145
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TGFBR1 for 
       RNA interference

<400>  145
ggtcctttct gtgcactatg a                                                 21


<210>  146
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TGFBR1 for 
       RNA interference

<400>  146
ggtggtagct aaagaacatt c                                                 21


<210>  147
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target TGFBR1 for 
       RNA interference

<400>  147
ggacctgtct acaggtgatc t                                                 21


<210>  148
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DNMT3A for 
       RNA interference

<400>  148
gccaaggtca ttgcaggaat g                                                 21


<210>  149
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DNMT3A for 
       RNA interference

<400>  149
gcagaacaag cccatgattg a                                                 21


<210>  150
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DNMT3A for 
       RNA interference

<400>  150
cccaaggtca aggagattat t                                                 21


<210>  151
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DNMT3A for 
       RNA interference

<400>  151
gcagaagtgc cggaacattg a                                                 21


<210>  152
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DNMT3A for 
       RNA interference

<400>  152
gcgtcacaca gaagcatatc c                                                 21


<210>  153
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DNMT3A for 
       RNA interference

<400>  153
ccggctcttc tttgagttct a                                                 21


<210>  154
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target A2aR for RNA 
       interference

<400>  154
cagaacgtca ccaactactt t                                                 21


<210>  155
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target A2aR for RNA 
       interference

<400>  155
ccatgctagg ttggaacaac t                                                 21


<210>  156
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target A2aR for RNA 
       interference

<400>  156
ccaagtggcc tgtctctttg a                                                 21


<210>  157
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target A2aR for RNA 
       interference

<400>  157
ggtgtctatt tgcggatctt c                                                 21


<210>  158
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target A2aR for RNA 
       interference

<400>  158
agaccttccg caagatcatt c                                                 21


<210>  159
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target A2aR for RNA 
       interference

<400>  159
tccttagcca tgagctcaag g                                                 21


<210>  160
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-c for RNA
       interference

<400>  160
gaaagtactg tggacacatg t                                                 21


<210>  161
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-c for RNA
       interference

<400>  161
gcacgtgtcc atcttcgagt t                                                 21


<210>  162
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-c for RNA
       interference

<400>  162
ggccaacact cctcaagaac t                                                 21


<210>  163
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-c for RNA
       interference

<400>  163
ggcttctacc tctacccaga t                                                 21


<210>  164
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-c for RNA
       interference

<400>  164
ggccatggac tccacatttg a                                                 21


<210>  165
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target Cbl-c for RNA
       interference

<400>  165
ggccgtgagt atctaccagt t                                                 21


<210>  166
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK alpha for
       RNA interference

<400>  166
gccagaagac aagttagaat t                                                 21


<210>  167
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK alpha for
       RNA interference

<400>  167
gctctggaag ttccagtata t                                                 21


<210>  168
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK alpha for
       RNA interference

<400>  168
ggaaatgatc tggctcgatg c                                                 21


<210>  169
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK alpha for
       RNA interference

<400>  169
gcaaagatcc tcaaggattt a                                                 21


<210>  170
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK alpha for
       RNA interference

<400>  170
ggatgcctct attgctcatc g                                                 21


<210>  171
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK alpha for
       RNA interference

<400>  171
gctatggtac ttcgaatttg c                                                 21


<210>  172
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK zeta for 
       RNA interference

<400>  172
ggaagggatt ccagcagaag t                                                 21


<210>  173
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK zeta for 
       RNA interference

<400>  173
gcaaggagat tgtggccatc a                                                 21


<210>  174
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK zeta for 
       RNA interference

<400>  174
gggcatcctt caagaggaag t                                                 21


<210>  175
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK zeta for 
       RNA interference

<400>  175
gcaaagatca tccagtcttt c                                                 21


<210>  176
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK zeta for 
       RNA interference

<400>  176
gctggagatg taccgcaaag t                                                 21


<210>  177
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target DGK zeta for 
       RNA interference

<400>  177
gcacaggatg agatttatat c                                                 21


<210>  178
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target MerTK for RNA
       interference

<400>  178
ggaagaccac atacaggaaa c                                                 21


<210>  179
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target MerTK for RNA
       interference

<400>  179
gcattggtgt ttcctgcatg a                                                 21


<210>  180
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target MerTK for RNA
       interference

<400>  180
gcacacggtt gggtagatta t                                                 21


<210>  181
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target MerTK for RNA
       interference

<400>  181
gggtctgtaa tggaaggaaa t                                                 21


<210>  182
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target MerTK for RNA
       interference

<400>  182
gcatgttgcg agatgacatg a                                                 21


<210>  183
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target MerTK for RNA
       interference

<400>  183
gcagaccgag tctacacaag t                                                 21


<210>  184
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP1 for RNA 
       interference

<400>  184
gcaccatcat ccacctcaag t                                                 21


<210>  185
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP1 for RNA 
       interference

<400>  185
ggtcacccac atcaaggtca t                                                 21


<210>  186
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP1 for RNA 
       interference

<400>  186
gggcaagaac cgctacaaga a                                                 21


<210>  187
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP1 for RNA 
       interference

<400>  187
ggaacaaatg cgtcccatac t                                                 21


<210>  188
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP1 for RNA 
       interference

<400>  188
gcctggactg tgacattgac a                                                 21


<210>  189
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP1 for RNA 
       interference

<400>  189
gaacctgcac actaagaaca a                                                 21


<210>  190
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP2 for RNA 
       interference

<400>  190
gcagatccta cctctgaaag g                                                 21


<210>  191
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP2 for RNA 
       interference

<400>  191
gcaatgacgg caagtctaaa g                                                 21


<210>  192
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP2 for RNA 
       interference

<400>  192
ggaactgaaa tacgacgttg g                                                 21


<210>  193
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP2 for RNA 
       interference

<400>  193
gcgtgttagg aacgtcaaag a                                                 21


<210>  194
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP2 for RNA 
       interference

<400>  194
gctcatgact atacgctaag a                                                 21


<210>  195
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target SHP2 for RNA 
       interference

<400>  195
ggagagaacg gtctggcaat a                                                 21


<210>  196
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PP2A for RNA 
       interference

<400>  196
gcagctgaac gagaaccaag t                                                 21


<210>  197
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PP2A for RNA 
       interference

<400>  197
ggagactgtg actcttcttg t                                                 21


<210>  198
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PP2A for RNA 
       interference

<400>  198
ggaatgccaa cgtttggaaa t                                                 21


<210>  199
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PP2A for RNA 
       interference

<400>  199
ggatcgttta caggaagttc c                                                 21


<210>  200
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PP2A for RNA 
       interference

<400>  200
gcctttgtat gtggaagtat a                                                 21


<210>  201
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target PP2A for RNA 
       interference

<400>  201
gcctgctgta tttatagtaa c                                                 21


<210>  202
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD45 for RNA 
       interference

<400>  202
gctgcacatc aaggagtaat t                                                 21


<210>  203
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD45 for RNA 
       interference

<400>  203
gctggaaata ctctggttag a                                                 21


<210>  204
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD45 for RNA 
       interference

<400>  204
ggagcttgtt gaaagggatg a                                                 21


<210>  205
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD45 for RNA 
       interference

<400>  205
gcagaatact ggccgtcaat g                                                 21


<210>  206
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD45 for RNA 
       interference

<400>  206
ggttatgttg tcaagctaag g                                                 21


<210>  207
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD45 for RNA 
       interference

<400>  207
gcagaaccca aggaattaat c                                                 21


<210>  208
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD148 for RNA
       interference

<400>  208
ggtgtaacat cacaggctta c                                                 21


<210>  209
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD148 for RNA
       interference

<400>  209
gccatagagt tcaggacaaa t                                                 21


<210>  210
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD148 for RNA
       interference

<400>  210
gcaattctcg ggtagaaata a                                                 21


<210>  211
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD148 for RNA
       interference

<400>  211
gctggcttca ccaacattac c                                                 21


<210>  212
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD148 for RNA
       interference

<400>  212
gggagcaaat catctgcatt c                                                 21


<210>  213
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target CD148 for RNA
       interference

<400>  213
gcgactcaaa tatcaccttg a                                                 21


<210>  214
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target IL-10R alpha 
       for RNA interference

<400>  214
gctcctgagg tatggaatag a                                                 21


<210>  215
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target IL-10R alpha 
       for RNA interference

<400>  215
gcaaatgaca catatgaaag c                                                 21


<210>  216
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target IL-10R alpha 
       for RNA interference

<400>  216
ggtctaaaga ggagtgcatc t                                                 21


<210>  217
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target IL-10R alpha 
       for RNA interference

<400>  217
gggctatttg aaacaggatc c                                                 21


<210>  218
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target IL-10R alpha 
       for RNA interference

<400>  218
gctgtaggaa tggaagcttc a                                                 21


<210>  219
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial shRNA sequence, included in shRNA to target IL-10R alpha 
       for RNA interference

<400>  219
gcttgtgttt gctgctaatg t                                                 21


<210>  220
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mU6-shTIM-3-><-shPD-1-hU6

<400>  220
gttaacaagg tcgggcagga agagggccta tttcccatga ttccttcata tttgcatata       60

cgatacaagg ctgttagaga gataattaga attaatttga ctgtaaacac aaagatatta      120

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      180

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      240

ttatatatct tgtggaaagg acgaaacacc gcctgtggtt ctattatatt atttcaagag      300

aataatataa tagaaccaca ggtttttgac tagtcaaaaa ggaattcgct cagaagaaat      360

ctcttgaatt tcttctgagc gaattccaaa caaggctttt ctccaaggga tatttatagt      420

ctcaaaacac acaattactt tacagttagg gtgagtttcc ttttgtgctg ttttttaaaa      480

taataattta gtatttgtat ctcttataga aatccaagcc tatcatgtaa aatgtagcta      540

gtattaaaaa gaacagatta tctgtctttt atcgcacatt aagcctctat agttactagg      600

aaatattata tgcaaattaa ccggggcagg ggagtagccg agcttctccc acaagtctgt      660

gcgagggggc cggcgcgggc ctagagatgg cggcgtcgga tcgctagcca tatgtctaga      720

gtatac                                                                 726


<210>  221
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shTIM-3-mU6<-->hU6-shPD-1

<400>  221
gttaaccaaa aacctgtggt tctattatat tattctcttg aaataatata atagaaccac       60

aggcggtgtt tcgtcctttc cacaagatat ataaagccaa gaaatcgaaa tactttcaag      120

ttacggtaag catatgatag tccattttaa aacataattt taaaactgca aactacccaa      180

gaaattatta ctttctacgt cacgtatttt gtactaatat ctttgtgttt acagtcaaat      240

taattctaat tatctctcta acagccttgt atcgtatatg caaatatgaa ggaatcatgg      300

gaaataggcc ctcttcctgc ccgaccttac tagtgatccg acgccgccat ctctaggccc      360

gcgccggccc cctcgcacag acttgtggga gaagctcggc tactcccctg ccccggttaa      420

tttgcatata atatttccta gtaactatag aggcttaatg tgcgataaaa gacagataat      480

ctgttctttt taatactagc tacattttac atgataggct tggatttcta taagagatac      540

aaatactaaa ttattatttt aaaaaacagc acaaaaggaa actcacccta actgtaaagt      600

aattgtgtgt tttgagacta taaatatccc ttggagaaaa gccttgtttg gaattcgctc      660

agaagaaatt caagagattt cttctgagcg aattcctttt tggctagcca tatgtctaga      720

gtatac                                                                 726


<210>  222
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA cassette base sequence


<220>
<221>  misc_feature
<222>  (323)..(343)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (353)..(373)
<223>  n is a, c, g, or t

<400>  222
gttaacgatc cgacgccgcc atctctaggc ccgcgccggc cccctcgcac agacttgtgg       60

gagaagctcg gctactcccc tgccccggtt aatttgcata taatatttcc tagtaactat      120

agaggcttaa tgtgcgataa aagacagata atctgttctt tttaatacta gctacatttt      180

acatgatagg cttggatttc tataagagat acaaatacta aattattatt ttaaaaaaca      240

gcacaaaagg aaactcaccc taactgtaaa gtaattgtgt gttttgagac tataaatatc      300

ccttggagaa aagccttgtt tgnnnnnnnn nnnnnnnnnn nnnttcaaga gannnnnnnn      360

nnnnnnnnnn nnntttttgg ttaac                                            385


<210>  223
<211>  409
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mU6-shPD-1 MCS base sequence

<400>  223
gttaacgatc cgacgccgcc atctctaggc ccgcgccggc cccctcgcac agacttgtgg       60

gagaagctcg gctactcccc tgccccggtt aatttgcata taatatttcc tagtaactat      120

agaggcttaa tgtgcgataa aagacagata atctgttctt tttaatacta gctacatttt      180

acatgatagg cttggatttc tataagagat acaaatacta aattattatt ttaaaaaaca      240

gcacaaaagg aaactcaccc taactgtaaa gtaattgtgt gttttgagac tataaatatc      300

ccttggagaa aagccttgtt tgcctgtggt tctattatat tatttcaaga gaataatata      360

atagaaccac aggtttttga ctagtgctag ccatatgtct agagtatac                  409


<210>  224
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hU6-shPD-1 base sequence

<400>  224
gttaacaagg tcgggcagga agagggccta tttcccatga ttccttcata tttgcatata       60

cgatacaagg ctgttagaga gataattaga attaatttga ctgtaaacac aaagatatta      120

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      180

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      240

ttatatatct tgtggaaagg acgaaacacc gcctgtggtt ctattatatt atttcaagag      300

aataatataa tagaaccaca ggtttttg                                         328


<210>  225
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22-CAR

<400>  225

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
    290                 295                 300                 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                325                 330                 335     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            340                 345                 350         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg 
465             


<210>  226
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-CAR

<400>  226

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  227
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta LNGFR_P2A_CD19-CAR

<400>  227

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg Trp Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Ala Leu Pro Val Thr Ala Leu 
    290                 295                 300                 


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Gln 
305                 310                 315                 320 


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                325                 330                 335     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
            340                 345                 350         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
        355                 360                 365             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    370                 375                 380                 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
385                 390                 395                 400 


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
                405                 410                 415     


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
        435                 440                 445             


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
    450                 455                 460                 


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
465                 470                 475                 480 


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
                485                 490                 495     


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
            500                 505                 510         


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        515                 520                 525             


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
    530                 535                 540                 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
545                 550                 555                 560 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                565                 570                 575     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            580                 585                 590         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
        595                 600                 605             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    610                 615                 620                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
625                 630                 635                 640 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                645                 650                 655     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            660                 665                 670         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        675                 680                 685             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    690                 695                 700                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
705                 710                 715                 720 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                725                 730                 735     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            740                 745                 750         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        755                 760                 765             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    770                 775                 780         


<210>  228
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR cloning primer #1

<400>  228
ggtatactct agacatatgg ctagcactag tcaaaaacct gtggttc                     47


<210>  229
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR cloning primer #1

<400>  229
ttgtaccgtt aacgatccga cgccgc                                            26


<210>  230
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR cloning primer #2

<400>  230
tgactagtca aaaacctgtg gttctattat attattctct tgaaataata taatagaacc       60

acaggcggtg tttcgtcctt tccacaagat atataaagcc aa                         102


<210>  231
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR cloning primer #2

<400>  231
gtaccgttaa caaggtcggg caggaagagg gcctatttcc catgattcct                  50


<210>  232
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR cloning primer #3

<400>  232
aggactagtc aaaaaggaat tcgctcagaa gaaatctct                              39


<210>  233
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR cloning primer #3

<400>  233
ctagctagcg atccgacgcc gccatct                                           27


<210>  234
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR cloning primer #4

<400>  234
atgttaacca aaaacctgtg gttctattat attattctct tg                          42


<210>  235
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR cloning primer #4

<400>  235
tcactagtaa ggtcgggcag gaagagggcc tatt                                   34


<210>  236
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward PCR cloning primer #5

<400>  236
taggccctca ctagtgatcc gacgccgcc                                         29


<210>  237
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse PCR cloning primer #5

<400>  237
ctagctagcc aaaaaggaat tcgctcagaa gaaatctc                               38


<210>  238
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIGIT-268

<400>  238
gcttctggcc atttgtaatg c                                                 21


<210>  239
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIGIT-2

<400>  239
gggagtactt ctgcatctat c                                                 21


<210>  240
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIGIT-739

<400>  240
gctgcatgac tacttcaatg t                                                 21


<210>  241
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIGIT-1

<400>  241
taacgtggat cttgatcata a                                                 21


<210>  242
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIGIT-1386

<400>  242
ggagacatac acaggccttc a                                                 21


<210>  243
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIGIT-1750

<400>  243
gcatttgggc cttgatctac c                                                 21


<210>  244
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-138

<400>  244
ccagctttcc agctttcctc t                                                 21


<210>  245
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-503

<400>  245
gatctcagcc ttctgcgaag a                                                 21


<210>  246
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1092

<400>  246
gcttcaacgt ctccatcatg t                                                 21


<210>  247
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1221

<400>  247
ggtctttcct cactgccaag t                                                 21


<210>  248
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1278

<400>  248
ctggagacaa tggcgacttt a                                                 21


<210>  249
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1379

<400>  249
gccactgtca cattggcaat c                                                 21


<210>  250
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1465

<400>  250
tccagtatct ggacaagaac g                                                 21


<210>  251
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1616

<400>  251
gcagcagtgt acttcacaga g                                                 21


<210>  252
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1702

<400>  252
gctgtttctc atccttggtg t                                                 21


<210>  253
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1751

<400>  253
gcctttggct ttcacctttg g                                                 21


<210>  254
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAG3-1954

<400>  254
tcagcagccc agtccaaata a                                                 21


<210>  255
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4-3

<400>  255
ggtggagctc atgtacccac c                                                 21


<210>  256
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4-1

<400>  256
cccaaattac gtgtactaca a                                                 21


<210>  257
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4-1058

<400>  257
gcatcacttg ggattaatat g                                                 21


<210>  258
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4-1154

<400>  258
gcgagggaga agactatatt g                                                 21


<210>  259
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4-1309

<400>  259
gccagtgatg ctaaaggttg t                                                 21


<210>  260
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4-1686

<400>  260
ggtggtatct gagttgactt g                                                 21


<210>  261
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tim3-1

<400>  261
gatgaaaggg atgtgaatta t                                                 21


<210>  262
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tim3-2

<400>  262
gggagcctcc ctgatataaa t                                                 21


<210>  263
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tim3-3

<400>  263
ggaattcgct cagaagaaa                                                    19


<210>  264
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tim3-4

<400>  264
ggaccaaact gaagctatat t                                                 21


<210>  265
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-1

<400>  265
cctgtggttc tattatatta t                                                 21


<210>  266
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-2

<400>  266
gcctagagaa gtttcaggga a                                                 21


<210>  267
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1-3

<400>  267
cattgtcttt cctagcggaa t                                                 21


<210>  268
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  18s rRNA Forward

<400>  268
gattaagtcc ctgccctttg                                                   20


<210>  269
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  18s rRNA Reverse

<400>  269
gttcacctac ggaaaccttg                                                   20


<210>  270
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 Forward

<400>  270
cctccacctt tacacatgcc                                                   20


<210>  271
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 Reverse

<400>  271
cttactgcct cagcttccct                                                   20


<210>  272
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2 Forward

<400>  272
ccaagaaggc cacagaactg a                                                 21


<210>  273
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2 Reverse

<400>  273
gttgtttcag atccctttag ttccag                                            26


<210>  274
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL4 Forward

<400>  274
actttgaaca gcctcacaga g                                                 21


<210>  275
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL4 Reverse

<400>  275
ccgagttgac cgtaacagac at                                                22


<210>  276
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL17A Forward

<400>  276
caaccgatcc acctcacctt                                                   20


<210>  277
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL17A Reverse

<400>  277
ggcactttgc ctcccagat                                                    19


<210>  278
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD25 Forward

<400>  278
cacaagctct gccactcgga a                                                 21


<210>  279
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD25 Reverse

<400>  279
tgcagtgacc tggaaggctc                                                   20


<210>  280
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4 Forward

<400>  280
ctacctgggc ataggcaacg                                                   20


<210>  281
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4 Reverse

<400>  281
ccccgaacta actgctgcaa                                                   20


<210>  282
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOXP3 Forward

<400>  282
gaaacagcac attcccagag ttc                                               23


<210>  283
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOXP3 Reverse

<400>  283
atggcccagc ggatgag                                                      17


<210>  284
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGF-beta1 Forward

<400>  284
cccagcatct gcaaagctc                                                    19


<210>  285
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGF-beta1 Reverse

<400>  285
gtccttgcgg aagtcaatgt                                                   20


<210>  286
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR1 Forward

<400>  286
acatgattca gccacagata cc                                                22


<210>  287
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR1 Reverse

<400>  287
gcatagatgt cagcacgttt g                                                 21


<210>  288
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR2 Forward

<400>  288
acgtgttgag agatcgagg                                                    19


<210>  289
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBR2 Reverse

<400>  289
cccagcactc agtcaacgtc                                                   20


