                         SEQUENCE LISTING

<110>  Leibniz-Institut fr Naturstoff-Forschung und 
       Infektionsbiologie
 
<120>  Modulators of c1q, in particular of the interaction of ApoE 
       with c1q, and uses of the modulators in the therapy of neuronal 
       diseases and inflammation

<130>  H32958WO

<150>  DE 10 2018 100 377.3
<151>  2018-01-09

<160>  12     

<170>  PatentIn version 3.5

<210>  1
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  2
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Thr Ser Gln Gly Trp Leu Val Ala Cys Val Leu Thr Met Thr 
1               5                   10                  15      


Leu Val Trp Thr Val Ala Glu Asp Val Cys Arg Ala Pro Asn Gly Lys 
            20                  25                  30          


Asp Gly Ala Pro Gly Asn Pro Gly Arg Pro Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Arg Gly Glu Pro Gly Ala Ala Gly Ile Arg Thr Gly Ile Arg 
    50                  55                  60                  


Gly Phe Lys Gly Asp Pro Gly Glu Ser Gly Pro Pro Gly Lys Pro Gly 
65                  70                  75                  80  


Asn Val Gly Leu Pro Gly Pro Ser Gly Pro Leu Gly Asp Ser Gly Pro 
                85                  90                  95      


Gln Gly Leu Lys Gly Val Lys Gly Asn Pro Gly Asn Ile Arg Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Gln Asn Pro Met Thr Leu Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Lys Val Leu Thr Asn Gln Glu Ser Pro Tyr 
    130                 135                 140                 


Gln Asn His Thr Gly Arg Phe Ile Cys Ala Val Pro Gly Phe Tyr Tyr 
145                 150                 155                 160 


Phe Asn Phe Gln Val Ile Ser Lys Trp Asp Leu Cys Leu Phe Ile Lys 
                165                 170                 175     


Ser Ser Ser Gly Gly Gln Pro Arg Asp Ser Leu Ser Phe Ser Asn Thr 
            180                 185                 190         


Asn Asn Lys Gly Leu Phe Gln Val Leu Ala Gly Gly Thr Val Leu Gln 
        195                 200                 205             


Leu Arg Arg Gly Asp Glu Val Trp Ile Glu Lys Asp Pro Ala Lys Gly 
    210                 215                 220                 


Arg Ile Tyr Gln Gly Thr Glu Ala Asp Ser Ile Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  3
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr 
            20                  25                  30          


Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly 
        35                  40                  45              


Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu 
    50                  55                  60                  


Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro 
65                  70                  75                  80  


Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly 
                85                  90                  95      


Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu 
            100                 105                 110         


Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg 
        115                 120                 125             


Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His 
    130                 135                 140                 


Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe 
145                 150                 155                 160 


Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser 
                165                 170                 175     


Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250             


<210>  4
<211>  253
<212>  PRT
<213>  Mus musculus

<400>  4

Met Lys Thr Gln Trp Gly Glu Val Trp Thr His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Phe Leu His Val Ser Trp Ala Gln Ser Ser Cys Thr Gly Pro 
            20                  25                  30          


Pro Gly Ile Pro Gly Ile Pro Gly Val Pro Gly Val Pro Gly Ser Asp 
        35                  40                  45              


Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp Leu Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Thr Pro Gly Lys Val Gly Pro Lys Gly Pro Val Gly Pro Lys 
                85                  90                  95      


Gly Thr Pro Gly Pro Ser Gly Pro Arg Gly Pro Lys Gly Asp Ser Gly 
            100                 105                 110         


Asp Tyr Gly Ala Thr Gln Lys Val Ala Phe Ser Ala Leu Arg Thr Ile 
        115                 120                 125             


Asn Ser Pro Leu Arg Pro Asn Gln Val Ile Arg Phe Glu Lys Val Ile 
    130                 135                 140                 


Thr Asn Ala Asn Glu Asn Tyr Glu Pro Arg Asn Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Leu Val Arg Gly Arg Asp Arg Asp Ser Met Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Gln Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Val Val Leu Lys Leu Glu Gln Glu Glu Val Val His Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Ile Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Thr Gly Phe Leu Leu Phe Pro Asp Met Asp Ala 
                245                 250             


<210>  5
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
            20                  25                  30          


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
        35                  40                  45              


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
    50                  55                  60                  


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
65                  70                  75                  80  


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
                85                  90                  95      


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
            100                 105                 110         


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
        115                 120                 125             


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
    130                 135                 140                 


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
                165                 170                 175     


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
            180                 185                 190         


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
        195                 200                 205             


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
    210                 215                 220                 


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Pro Asp 
                245 


<210>  6
<211>  246
<212>  PRT
<213>  Mus musculus

<400>  6

Met Val Val Gly Pro Ser Cys Gln Pro Pro Cys Gly Leu Cys Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ala Leu Pro Leu Arg Ser Gln Ala Ser Ala Gly 
            20                  25                  30          


Cys Tyr Gly Ile Pro Gly Met Pro Gly Met Pro Gly Ala Pro Gly Lys 
        35                  40                  45              


Asp Gly His Asp Gly Leu Gln Gly Pro Lys Gly Glu Pro Gly Ile Pro 
    50                  55                  60                  


Ala Val Pro Gly Thr Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Met Pro Gly His Arg Gly Lys Asn Gly Pro Arg Gly Thr Ser Gly Leu 
                85                  90                  95      


Pro Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Val Glu 
            100                 105                 110         


Gly Arg Tyr Lys Gln Lys His Gln Ser Val Phe Thr Val Thr Arg Gln 
        115                 120                 125             


Thr Thr Gln Tyr Pro Glu Ala Asn Ala Leu Val Arg Phe Asn Ser Val 
    130                 135                 140                 


Val Thr Asn Pro Gln Gly His Tyr Asn Pro Ser Thr Gly Lys Phe Thr 
145                 150                 155                 160 


Cys Glu Val Pro Gly Leu Tyr Tyr Phe Val Tyr Tyr Thr Ser His Thr 
                165                 170                 175     


Ala Asn Leu Cys Val His Leu Asn Leu Asn Leu Ala Arg Val Ala Ser 
            180                 185                 190         


Phe Cys Asp His Met Phe Asn Ser Lys Gln Val Ser Ser Gly Gly Val 
        195                 200                 205             


Leu Leu Arg Leu Gln Arg Gly Asp Glu Val Trp Leu Ser Val Asn Asp 
    210                 215                 220                 


Tyr Asn Gly Met Val Gly Ile Glu Gly Ser Asn Ser Val Phe Ser Gly 
225                 230                 235                 240 


Phe Leu Leu Phe Pro Asp 
                245     


<210>  7
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln 
    210                 215                 


<210>  8
<211>  311
<212>  PRT
<213>  Mus musculus

<400>  8

Met Lys Ala Leu Trp Ala Val Leu Leu Val Thr Leu Leu Thr Gly Cys 
1               5                   10                  15      


Leu Ala Glu Gly Glu Pro Glu Val Thr Asp Gln Leu Glu Trp Gln Ser 
            20                  25                  30          


Asn Gln Pro Trp Glu Gln Ala Leu Asn Arg Phe Trp Asp Tyr Leu Arg 
        35                  40                  45              


Trp Val Gln Thr Leu Ser Asp Gln Val Gln Glu Glu Leu Gln Ser Ser 
    50                  55                  60                  


Gln Val Thr Gln Glu Leu Thr Ala Leu Met Glu Asp Thr Met Thr Glu 
65                  70                  75                  80  


Val Lys Ala Tyr Lys Lys Glu Leu Glu Glu Gln Leu Gly Pro Val Ala 
                85                  90                  95      


Glu Glu Thr Arg Ala Arg Leu Gly Lys Glu Val Gln Ala Ala Gln Ala 
            100                 105                 110         


Arg Leu Gly Ala Asp Met Glu Asp Leu Arg Asn Arg Leu Gly Gln Tyr 
        115                 120                 125             


Arg Asn Glu Val His Thr Met Leu Gly Gln Ser Thr Glu Glu Ile Arg 
    130                 135                 140                 


Ala Arg Leu Ser Thr His Leu Arg Lys Met Arg Lys Arg Leu Met Arg 
145                 150                 155                 160 


Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala Val Tyr Lys Ala Gly Ala 
                165                 170                 175     


Arg Glu Gly Ala Glu Arg Gly Val Ser Ala Ile Arg Glu Arg Leu Gly 
            180                 185                 190         


Pro Leu Val Glu Gln Gly Arg Gln Arg Thr Ala Asn Leu Gly Ala Gly 
        195                 200                 205             


Ala Ala Gln Pro Leu Arg Asp Arg Ala Gln Ala Phe Gly Asp Arg Ile 
    210                 215                 220                 


Arg Gly Arg Leu Glu Glu Val Gly Asn Gln Ala Arg Asp Arg Leu Glu 
225                 230                 235                 240 


Glu Val Arg Glu His Met Glu Glu Val Arg Ser Lys Met Glu Glu Gln 
                245                 250                 255     


Thr Gln Gln Ile Arg Leu Gln Ala Glu Ile Phe Gln Ala Arg Leu Lys 
            260                 265                 270         


Gly Trp Phe Glu Pro Ile Val Glu Asp Met His Arg Gln Trp Ala Asn 
        275                 280                 285             


Leu Met Glu Lys Ile Gln Ala Ser Val Ala Thr Asn Pro Ile Ile Thr 
    290                 295                 300                 


Pro Val Ala Gln Glu Asn Gln 
305                 310     


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9
Leu Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val 
1               5                   10


<210>  10
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  10
Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val 
1               5                   10


<210>  11
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  11
Ser His Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala 
1               5                   10


<210>  12
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  12
Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg Thr 
1               5                   10                  15

Arg Asp Arg Leu Asp Glu Val
            20

