﻿                         序列表

<110>  江苏恒瑞医药股份有限公司
       上海恒瑞医药有限公司

<120>  PD-L1抗体、其抗原结合片段及医药用途

<150>  CN201810023267.0
<151>  2018-1-10

<160>  72

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  445
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HRP00049抗体重链序列


<400>  1
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Asp 
            20                  25                  30          
Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ser Gly Gly Trp Leu Ala Pro Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 

<210>  2
<211>  1338
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>  gene
<223>  HRP00049抗体重链序列编码基因序列


<400>  2
caggtgcaac tgcaggagag cggccccgga ctcgtgaaac cctcccagac cctgagcctg        60
acctgtaccg tgagcggcgg cagcatcagc aacgactact ggacttggat caggcagcac       120
cccggcaaag gcctggagta catcggctac atcagctaca ccggctccac ctactacaac       180
cccagcctga agtccagggt gaccatcagc cgggacacca gcaagaacca gttcagcctg       240
aagctgagca gcgtgaccgc tgccgacaca gccgtgtact attgtgccag aagcggcgga       300
tggctggccc ctttcgacta ctggggcaga ggcaccctgg tgaccgtgag cagcgcttcc       360
accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca       420
gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac       480
tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc       540
tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcacgaa gacctacacc       600
tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agagagttga gtccaaatat       660
ggtcccccat gcccaccatg cccagcacct gaggctgctg ggggaccatc agtcttcctg       720
ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg       780
gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg       840
gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg       900
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag       960
gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag      1020
ccccgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag      1080
gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag      1140
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc      1200
tccttcttcc tctacagcag gctcaccgtg gacaagagca ggtggcagga ggggaatgtc      1260
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc      1320
ctgtctctgg gtaaatga                                                    1338

<210>  3
<211>  220
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HRP00049抗体轻链序列


<400>  3
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr His 
            20                  25                  30          
Ser Asn Gln Lys His Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210>  4
<211>  663
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>  gene
<223>  HRP00049抗体轻链序列编码基因序列


<400>  4
gacatcgtga tgacccagag ccctgatagc ctggctgtga gcctgggcga gagagccacc        60
atcaactgca agagcagcca gagcctgttc taccatagca accagaagca cagcctcgcc       120
tggtatcagc agaagcccgg ccaacccccc aagctgctga tctacggcgc cagcacaaga       180
gagagcggag tgcccgatag gttcagcggc agcggatccg gcaccgattt caccctgacc       240
atcagcagcc tgcaggccga ggatgtggcc gtgtactact gccagcagta ctacggctac       300
ccttacacct tcggcggcgg caccaaggtg gagatcaagc gtacggtggc tgcaccatct       360
gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc       420
ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc       480
caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc       540
ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc       600
gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt       660
tga                                                                     663

<210>  5
<211>  446
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HRP00052抗体重链序列


<400>  5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Gly Pro Asn Ser Gly Phe Thr Ser Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     

<210>  6
<211>  1341
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>  gene
<223>  HRP00052抗体重链序列编码基因序列


<400>  6
caggtgcaac tggtgcagag cggtgccgag gtgaagaagc ctggcgcaag cgtgaaagtg        60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaggcaggcc       120
cctggacagg gcctggagtg gatgggcagg atcgggccca acagtggttt cactagctac       180
aatgaaaagt tcaagaacag ggtaaccatg accagggaca cctccaccag cacagtgtat       240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgtgc cagaggcggc       300
agcagctacg actacttcga ctattggggc cagggcacca ccgtgaccgt gagcagtgct       360
tccaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc       420
acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg       480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga       540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac       600
acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa       660
tatggtcccc catgcccacc atgcccagca cctgaggctg ctgggggacc atcagtcttc       720
ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc       780
gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc       840
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agttcaacag cacgtaccgt       900
gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc       960
aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg      1020
cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat gaccaagaac      1080
caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      1140
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac      1200
ggctccttct tcctctacag caggctcacc gtggacaaga gcaggtggca ggaggggaat      1260
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      1320
tccctgtctc tgggtaaatg a                                                1341

<210>  7
<211>  218
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HRP00052抗体轻链序列


<400>  7
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210>  8
<211>  657
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>  gene
<223>  HRP00052抗体轻链序列编码基因序列


<400>  8
gacatcgtgc tgacccagag tcccgcctca cttgccgtga gccccggtca gagggccacc        60
atcacctgta gggccagcga gagcgtgagc atccacggca cccacctgat gcactggtat       120
caacagaaac ccggccagcc ccccaaactg ctgatctacg ccgccagcaa cctggagagc       180
ggcgtgcccg ccaggttcag cggctccggc agcggcaccg acttcaccct cactatcaac       240
cccgtggagg ccgaggacac cgccaactac tactgccagc agagcttcga ggaccccctg       300
accttcggcc agggcaccaa gctggagatc aagcgtacgg tggctgcacc atctgtcttc       360
atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg       420
aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg       480
ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc       540
agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc       600
acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttga          657

<210>  9
<211>  401
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  PEPTIDE
<223>  人PD-L1-IgG1Fc


<400>  9
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn 
            20                  25                  30          
Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
        35                  40                  45              
Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
    50                  55                  60                  
Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
65                  70                  75                  80  
Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
                85                  90                  95      
Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
            100                 105                 110         
Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
        115                 120                 125             
Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
    130                 135                 140                 
Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 
Pro Ala Gly Gln Phe Gln Thr Leu Val Glu Pro Lys Ser Ser Asp Lys 
                165                 170                 175     
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            180                 185                 190         
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 
Lys 
    

<210>  10
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00049抗体HCDR1序列1


<400>  10
Asp Gly Ser Ala Tyr Trp Ser 
1               5           

<210>  11
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00049抗体HCDR1序列2


<400>  11
Asn Asp Tyr Trp Thr 
1               5   

<210>  12
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00049抗体酵母菌展示文库的抗体HCDR2通式序列


<220>
<221>  UNSURE
<222>  (1)..(1)
<223>  Xaa选自Phe或Met


<220>
<221>  UNSURE
<222>  (4)..(4)
<223>  Xaa选自Arg或Val


<220>
<221>  UNSURE
<222>  (10)..(10)
<223>  Xaa选自Asn或His


<400>  12
Xaa Ile Ser Xaa Ala Gly Ser Thr Tyr Xaa Thr Pro Ser Leu Lys Gly 
1               5                   10                  15      

<210>  13
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00049抗体HCDR3


<400>  13
Ser Gly Gly Trp Leu Ala Pro Phe Asp Tyr 
1               5                   10  

<210>  14
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00049抗体LCDR1


<400>  14
Lys Ser Ser Gln Ser Leu Phe Tyr His Ser Asn Gln Lys His Ser Leu 
1               5                   10                  15      
Ala 
    

<210>  15
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00049抗体LCDR2


<400>  15
Gly Ala Ser Thr Arg Glu Ser 
1               5           

<210>  16
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00049抗体LCDR3


<400>  16
Gln Gln Tyr Tyr Gly Tyr Pro Tyr Thr 
1               5                   

<210>  17
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00049抗体酵母菌展示文库的抗体重链可变区序列通式


<220>
<221>  UNSURE
<222>  (52)..(52)
<223>  Xaa选自Phe或Met


<220>
<221>  UNSURE
<222>  (55)..(55)
<223>  Xaa选自Arg或Val


<220>
<221>  UNSURE
<222>  (61)..(61)
<223>  Xaa选自Asn或His


<400>  17
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Gly 
            20                  25                  30          
Ser Ala Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Tyr Ile Gly Xaa Ile Ser Xaa Ala Gly Ser Thr Tyr Xaa Thr Pro Ser 
    50                  55                  60                  
Leu Lys Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ser Gly Gly Trp Leu Ala Pro Phe Asp Tyr Trp Gly Arg 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  18
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00049抗体酵母菌展示文库的抗体重链可变区序列通式


<220>
<221>  UNSURE
<222>  (50)..(50)
<223>  Xaa选自Phe或Met


<220>
<221>  UNSURE
<222>  (53)..(53)
<223>  Xaa选自Arg或Val


<220>
<221>  UNSURE
<222>  (59)..(59)
<223>  Xaa选自Asn或His


<400>  18
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Asp 
            20                  25                  30          
Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Xaa Ile Ser Xaa Ala Gly Ser Thr Tyr Xaa Thr Pro Ser Leu Lys 
    50                  55                  60                  
Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ser Gly Gly Trp Leu Ala Pro Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  19
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00049抗体轻链可变区序列


<400>  19
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr His 
            20                  25                  30          
Ser Asn Gln Lys His Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys 
    

<210>  20
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00052抗体酵母菌展示文库的抗体HCDR1序列通式


<220>
<221>  UNSURE
<222>  (1)..(1)
<223>  Xaa选自Ser和Asp


<220>
<221>  UNSURE
<222>  (2)..(2)
<223>  Xaa选自Tyr和Lys


<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa选自His和Met


<400>  20
Xaa Xaa Trp Met Xaa 
1               5   

<210>  21
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00052抗体酵母菌展示文库的抗体HCDR2序列通式


<220>
<221>  UNSURE
<222>  (3)..(3)
<223>  Xaa选自Thr，Ser，His和Gly


<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa选自Ser，Asn和Gly


<220>
<221>  UNSURE
<222>  (6)..(6)
<223>  Xaa选自Ser，Leu和Gly


<220>
<221>  UNSURE
<222>  (8)..(8)
<223>  Xaa选自Phe，Leu，Trp和Met


<220>
<221>  UNSURE
<222>  (9)..(9)
<223>  Xaa选自Ala，Pro和Thr


<220>
<221>  UNSURE
<222>  (10)..(10)
<223>  Xaa选自Met，Val，Leu和Ser


<220>
<221>  UNSURE
<222>  (15)..(15)
<223>  Xaa选自Phe和Tyr



<400>  21
Arg Ile Xaa Pro Xaa Xaa Gly Xaa Xaa Xaa Tyr Asn Glu Lys Xaa Lys 
1               5                   10                  15      
Asn 
    

<210>  22
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00052抗体HCDR3序列


<400>  22
Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr 
1               5                   10  

<210>  23
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00052抗体LCDR1序列


<400>  23
Arg Ala Ser Glu Ser Val Ser Ile His Gly Thr His Leu Met His 
1               5                   10                  15  

<210>  24
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00052抗体酵母菌展示文库的抗体LCDR2序列通式


<220>
<221>  UNSURE
<222>  (1)..(1)
<223>  Xaa选自Val和Ala


<220>
<221>  UNSURE
<222>  (4)..(4)
<223>  Xaa选自Tyr和Asn


<220>
<221>  UNSURE
<222>  (5)..(5)
<223>  Xaa选自Ala，Leu和Val


<220>
<221>  UNSURE
<222>  (6)..(6)
<223>  Xaa选自Glu，Phe，Trp,Tyr和Ala


<400>  24
Xaa Ala Ser Xaa Xaa Xaa Ser 
1               5           

<210>  25
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  HRP00052抗体LCDR3序列


<400>  25
Gln Gln Ser Phe Glu Asp Pro Leu Thr 
1               5                   

<210>  26
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00052抗体酵母菌展示文库的抗体重链可变区序列通式


<220>
<221>  UNSURE
<222>  (31)..(31)
<223>  Xaa选自Ser和Asp


<220>
<221>  UNSURE
<222>  (32)..(32)
<223>  Xaa选自Tyr和Lys


<220>
<221>  UNSURE
<222>  (35)..(35)
<223>  Xaa选自His和Met


<220>
<221>  UNSURE
<222>  (52)..(52)
<223>  Xaa选自Thr，Ser，His和Gly


<220>
<221>  UNSURE
<222>  (54)..(54)
<223>  Xaa选自Ser，Asn和Gly


<220>
<221>  UNSURE
<222>  (55)..(55)
<223>  Xaa选自Ser，Leu和Gly


<220>
<221>  UNSURE
<222>  (57)..(57)
<223>  Xaa选自Phe，Leu，Trp和Met


<220>
<221>  UNSURE
<222>  (58)..(58)
<223>  Xaa选自Ala，Pro和Thr


<220>
<221>  UNSURE
<222>  (59)..(59)
<223>  Xaa选自Met，Val，Leu和Ser


<220>
<221>  UNSURE
<222>  (64)..(64)
<223>  Xaa选自Phe和Tyr


<400>  26
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa 
            20                  25                  30          
Trp Met Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Xaa Pro Xaa Xaa Gly Xaa Xaa Xaa Tyr Asn Glu Lys Xaa 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  27
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  来源于HRP00052抗体酵母菌展示文库的抗体轻链可变区序列通式


<220>
<221>  UNSURE
<222>  (54)..(54)
<223>  Xaa选自Val和Ala


<220>
<221>  UNSURE
<222>  (57)..(57)
<223>  Xaa选自Tyr和Asn


<220>
<221>  UNSURE
<222>  (58)..(58)
<223>  Xaa选自Ala，Leu和Val


<220>
<221>  UNSURE
<222>  (59)..(59)
<223>  Xaa选自Glu，Phe，Trp，Tyr和Ala



<400>  27
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Xaa Ala Ser Xaa Xaa Xaa Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  28
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  9-2 H5的HCDR2序列


<400>  28
Phe Ile Ser Arg Ala Gly Ser Thr Tyr Asn Thr Pro Ser Leu Lys Gly 
1               5                   10                  15      

<210>  29
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  9-2 H7的HCDR2序列


<400>  29
Met Ile Ser Val Ala Gly Ser Thr Tyr His Thr Pro Ser Leu Lys Gly 
1               5                   10                  15      

<210>  30
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H12 的HCDR1


<400>  30
Ser Tyr Trp Met His 
1               5   

<210>  31
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5  H15 的HCDR1


<400>  31
Asp Lys Trp Met Met 
1               5   

<210>  32
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H12 的HCDR2


<400>  32
Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210>  33
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H13 的HCDR2


<400>  33
Arg Ile Ser Pro Ser Leu Gly Leu Ala Val Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210>  34
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H14 的HCDR2


<400>  34
Arg Ile His Pro Ser Leu Gly Leu Pro Leu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210>  35
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H17的HCDR2


<400>  35
Arg Ile Gly Pro Asn Leu Gly Trp Ala Met Tyr Asn Glu Lys Tyr Lys 
1               5                   10                  15      
Asn 
    

<210>  36
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H18 的HCDR2


<400>  36
Arg Ile Ser Pro Ser Ser Gly Met Ala Val Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210>  37
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H19 的HCDR2


<400>  37
Arg Ile Ser Pro Gly Gly Gly Phe Thr Leu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210>  38
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H20的 HCDR3


<400>  38
Arg Ile Gly Pro Asn Ser Gly Phe Thr Ser Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210>  39
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L64 的LCDR2序列


<400>  39
Val Ala Ser Tyr Ala Ala Ser 
1               5           

<210>  40
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L61的LCDR2序列


<400>  40
Ala Ala Ser Asn Leu Glu Ser 
1               5           

<210>  41
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L66的LCDR2序列


<400>  41
Val Ala Ser Asn Val Phe Ser 
1               5           

<210>  42
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  9-2 H5重链可变区


<400>  42
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Gly 
            20                  25                  30          
Ser Ala Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Tyr Ile Gly Phe Ile Ser Arg Ala Gly Ser Thr Tyr Asn Thr Pro Ser 
    50                  55                  60                  
Leu Lys Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ser Gly Gly Trp Leu Ala Pro Phe Asp Tyr Trp Gly Arg 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  43
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  9-2 H6重链可变区


<400>  43
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Asp 
            20                  25                  30          
Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Phe Ile Ser Arg Ala Gly Ser Thr Tyr Asn Thr Pro Ser Leu Lys 
    50                  55                  60                  
Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ser Gly Gly Trp Leu Ala Pro Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  44
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  9-2 H7重链可变区


<400>  44
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Asp 
            20                  25                  30          
Tyr Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Met Ile Ser Val Ala Gly Ser Thr Tyr His Thr Pro Ser Leu Lys 
    50                  55                  60                  
Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ser Gly Gly Trp Leu Ala Pro Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  45
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  9-2 L11轻链可变区


<400>  45
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr His 
            20                  25                  30          
Ser Asn Gln Lys His Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys 
    

<210>  46
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H12重链可变区


<400>  46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  47
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H13重链可变区


<400>  47
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ser Pro Ser Leu Gly Leu Ala Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  48
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H14重链可变区


<400>  48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile His Pro Ser Leu Gly Leu Pro Leu Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  49
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H15重链可变区


<400>  49
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Asn Gly Tyr Thr Phe Thr Asp Lys 
            20                  25                  30          
Trp Met Met Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  50
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H16重链可变区


<400>  50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Met Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ser Pro Ser Leu Gly Leu Ala Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  51
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H17重链可变区


<400>  51
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Gly Pro Asn Leu Gly Trp Ala Met Tyr Asn Glu Lys Tyr 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  52
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H18重链可变区


<400>  52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ser Pro Ser Ser Gly Met Ala Val Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  53
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H19重链可变区


<400>  53
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ser Pro Gly Gly Gly Phe Thr Leu Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  54
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H20重链可变区


<400>  54
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Gly Pro Asn Ser Gly Phe Thr Ser Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  55
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L64轻链可变区


<400>  55
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Tyr Ala Ala Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  56
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L61轻链可变区


<400>  56
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  57
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L66轻链可变区


<400>  57
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Phe Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  58
<211>  330
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  IgG1重链恒定区


<400>  58
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  59
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  kappa轻链恒定区


<400>  59
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  60
<211>  327
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  人IgG4重链恒定区


<400>  60
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210>  61
<211>  450
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  Avelumab(A09) 的重链序列


<400>  61
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 

<210>  62
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  Avelumab(A09) 的轻链序列


<400>  62
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      
Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         
Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 
Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             
Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     

<210>  63
<211>  448
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  3280A(Genetech) 的重链序列


<400>  63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             

<210>  64
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  3280A(Genetech)的轻链序列


<400>  64
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  65
<211>  327
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  人IgG4 S228P重链恒定区


<400>  65
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  66
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 H21重链可变区


<400>  66
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Lys 
            20                  25                  30          
Trp Met Met Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L67的LCDR2


<400>  67
Val Ala Ser Asn Val Glu Ser 
1               5           



<210>  68
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L68的LCDR2


<400>  68
Val Ala Ser Asn Val Trp Ser 
1               5  



<210>  69
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L69的LCDR2


<400>  69
Val Ala Ser Asn Val Tyr Ser 
1               5           



<210>  70
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L67轻链可变区


<400>  70
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  71
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L68轻链可变区


<400>  71
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Trp Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     



<210>  72
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  24D5 L69轻链可变区


<400>  72
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Val Tyr Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     
