﻿                         序列表

<110>  南京任诺药业有限公司

<120>  一种具备高效中和活性的人源化抗人CD146单克隆抗体

<130>  2017

<160>  38

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  118
<212>  PRT
<213>  人工序列 (Artificial Sequence)

<400>  1
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  2
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  3
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Phe Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  4
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  5
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Phe Thr Leu Ser Val Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  6
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  7
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  8
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  9
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  10
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  11
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Thr Asp Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Phe Thr Leu Ser Val Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Met Val Thr Val Ser Ser 
        115             

<210>  12
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ile Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

<210>  13
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ile Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

<210>  14
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ile Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

<210>  15
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ile Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

<210>  16
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Asp Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ile Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

<210>  17
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ile Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

<210>  18
<211>  330
<212>  PRT
<213>  智人(homo sapiens)

<400>  18
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  19
<211>  107
<212>  PRT
<213>  智人(homo sapiens)

<400>  19
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  20
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  20
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggcta caccttctcc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccatc tcccgcgaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  21
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  21
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggctt caccttctcc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg gatcgcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccatc tcccgcgaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  22
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  22
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgcca cctccggcta catcttcacc aactactgga tccactgggt gaagcaggcc       120
cccggcaagg gcctggagtg gatcgcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggcaa gttcaccctg tccgtggaca agtccaagaa caccgcctac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  23
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  23
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggctt caccttctcc aactactgga tccactgggt gaagcaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccatc tcccgcgaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  24
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggcta catcttcacc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggcaa gttcaccctg tccgtggaca agtccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  25
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  25
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggctt caccttctcc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccatc tcccgcgaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  26
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  26
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgcca cctccggctt caccttctcc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccatc tcccgcgaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  27
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  27
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggctt caccttctcc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccctg tcccgcgaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  28
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  28
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggctt caccttctcc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccatc tcccgcgaca agtccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  29
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  29
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggctt caccttcacc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccatc tcccgcgaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  30
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  30
caggtgcagc tggtggagtc cggcggcggc gtggtgcagc ccggccgctc cctgcgcctg        60
tcctgcgccg cctccggctt caccttctcc aactactgga tccactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggcccgc atctaccccg gcaccgacat cacctactac       180
aacgagaagt tcaagggccg cttcaccctg tccgtggaca actccaagaa caccctgtac       240
ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgcgc ccgctccggc       300
ggctactggt acttcgacgt gtggggcgcc ggcaccatgg tgaccgtgtc ctcc             354

<210>  31
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  31
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc        60
atcacctgcc gcgcctccaa gtccgtgtcc atctccggct actcctacat gcactggtac       120
cagcagaagc ccggcaaggc ccccaagctg ctgatctacc tggcctccaa cctggagtcc       180
ggcgtgccct cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc       240
tccctgcagc ccgaggactt cgccacctac tactgccagc actcccgcga gctgccctac       300
accttcggcc agggcaccaa gctggagatc aagcgc                                 336

<210>  32
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  32
gagatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc        60
atcacctgcc gcgcctccaa gtccgtgtcc atctccggct actcctacat gcactggtac       120
cagcagaagc ccggcaaggc ccccaagctg ctgatctacc tggcctccaa cctggagtcc       180
ggcgtgccct cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc       240
tccctgcagc ccgaggactt cgccacctac tactgccagc actcccgcga gctgccctac       300
accttcggcc agggcaccaa gctggagatc aagcgc                                 336

<210>  33
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  33
gacatcgtga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc        60
atcacctgcc gcgcctccaa gtccgtgtcc atctccggct actcctacat gcactggtac       120
cagcagaagc ccggcaaggc ccccaagctg ctgatctacc tggcctccaa cctggagtcc       180
ggcgtgccct cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc       240
tccctgcagc ccgaggactt cgccacctac tactgccagc actcccgcga gctgccctac       300
accttcggcc agggcaccaa gctggagatc aagcgc                                 336

<210>  34
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  34
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc        60
atcacctgcc gcgcctccaa gtccgtgtcc atctccggct actcctacat gcactggtac       120
cagcagaagc ccggcaaggc ccccaagctg ctgatctacc tggcctccaa cctggagtcc       180
ggcgtgcccg cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc       240
tccctgcagc ccgaggactt cgccacctac tactgccagc actcccgcga gctgccctac       300
accttcggcc agggcaccaa gctggagatc aagcgc                                 336

<210>  35
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  35
gacctgcaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc        60
atcacctgcc gcgcctccaa gtccgtgtcc atctccggct actcctacat gcactggtac       120
cagcagaagc ccggcaaggc ccccaagctg ctgatctacc tggcctccaa cctggagtcc       180
ggcgtgccct cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc       240
tccctgcagc ccgaggactt cgccacctac tactgccagc actcccgcga gctgccctac       300
accttcggcc agggcaccaa gctggagatc aagcgc                                 336

<210>  36
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  36
gagctggtga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc        60
atcacctgcc gcgcctccaa gtccgtgtcc atctccggct actcctacat gcactggtac       120
cagcagaagc ccggcaaggc ccccaagctg ctgatctacc tggcctccaa cctggagtcc       180
ggcgtgcccg cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc       240
tccctgcagc ccgaggactt cgccacctac tactgccagc actcccgcga gctgccctac       300
accttcggcc agggcaccaa gctggagatc aagcgc                                 336

<210>  37
<211>  990
<212>  DNA
<213>  智人(homo sapiens)

<400>  37
gcctccacca agggcccctc cgtgttcccc ctggccccct cctccaagtc cacctccggc        60
ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc       120
tggaactccg gcgccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagtcctcc       180
ggcctgtact ccctgtcctc cgtggtgacc gtgccctcct cctccctggg cacccagacc       240
tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagccc       300
aagtcctgcg acaagaccca cacctgcccc ccctgccccg cccccgagct gctgggcggc       360
ccctccgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatctc ccgcaccccc       420
gaggtgacct gcgtggtggt ggacgtgtcc cacgaggacc ccgaggtgaa gttcaactgg       480
tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgcgagga gcagtacaac       540
tccacctacc gcgtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag       600
gagtacaagt gcaaggtgtc caacaaggcc ctgcccgccc ccatcgagaa gaccatctcc       660
aaggccaagg gccagccccg cgagccccag gtgtacaccc tgcccccctc ccgcgacgag       720
ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc ctccgacatc       780
gccgtggagt gggagtccaa cggccagccc gagaacaact acaagaccac cccccccgtg       840
ctggactccg acggctcctt cttcctgtac tccaagctga ccgtggacaa gtcccgctgg       900
cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc       960
cagaagtccc tgtccctgtc ccccggcaag                                        990

<210>  38
<211>  320
<212>  DNA
<213>  智人(homo sapiens)

<400>  38
cgcaccgtgg ccgccccctc cgtgttcatc ttccccccct ccgacgagca gctgaagtcc        60
ggcaccgcct ccgtggtgtg cctgctgaac aacttctacc cccgcgaggc caaggtgcag       120
tggaaggtgg acaacgccct gcagtccggc actcccagga gtccgtgacc gagcaggact       180
ccaaggactc cacctactcc ctgtcctcca ccctgaccct gtccaaggcc gactacgaga       240
agcacaaggt gtacgcctgc gaggtgaccc accagggcct gtcctccccc gtgaccaagt       300
ccttcaaccg cggcgagtgc                                                   320

