                         SEQUENCE LISTING

<110>  Washington University
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITION OF ALPHAVIRUS INFECTION

<130>  017583/WO

<150>  62/671,680
<151>  2018-05-15

<150>  62/613,658
<151>  2018-01-04

<150>  62/672,080
<151>  2018-05-16

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  954
<212>  DNA
<213>  homo sapiens

<400>  1
gtcctgttgc atagcggctc ctctgtcccg gccgcagcgg gatcaagcgt agtgagcgag       60

tcagcagttt cctgggaagc gggggcaagg gctgttctga ggtgtcagag cccaaggatg      120

gtgtggacgc aagaccggct ccacgacagg caaagagtgc ttcactggga cctcagggga      180

cccggtggtg gcccagcacg ccggctcctg gacctctata gcgcgggaga acaacgagta      240

tacgaagcta gggacagagg aagactggag ctttcagcca gtgcgttcga tgatggaaat      300

ttttcacttc tgatccgggc tgtggaagaa actgatgctg gactgtatac ttgtaatctc      360

caccatcact actgccacct ctatgagtca ttggctgtca gactggaagt taccgatggc      420

ccgcccgcca caccagctta ctgggatggc gaaaaagaag tacttgctgt cgcgcgaggt      480

gcccctgcgc tcctgacatg cgtcaacagg ggtcacgttt ggactgatcg gcacgtcgaa      540

gaggctcagc aagtagttca ctgggaccgc cagccgcctg gcgtacctca cgatagggcc      600

gaccgcctct tggacctcta cgcctccggt gaaaggaggg cctatgggcc tctgttcctc      660

agagataggg ttgcggtggg cgcagatgcc tttgaacgag gcgatttcag cctccgcatt      720

gagcccctgg aggtagccga tgagggcacc tactcctgtc atctgcatca tcattattgc      780

ggattgcacg agaggagggt cttccacttg actgtagctg aaccgcatgc tgaaccgcca      840

cctcgcggat cacccggaaa cggtagcagt cattccgggg ctcccgggcc ggatccgaca      900

ttggcacgag ggcataacgt aataaatgtc atcgttcccg agtcacgcgc tcat            954


<210>  2
<211>  318
<212>  PRT
<213>  homo sapiens

<400>  2

Val Leu Leu His Ser Gly Ser Ser Val Pro Ala Ala Ala Gly Ser Ser 
1               5                   10                  15      


Val Val Ser Glu Ser Ala Val Ser Trp Glu Ala Gly Ala Arg Ala Val 
            20                  25                  30          


Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln Asp Arg Leu His 
        35                  40                  45              


Asp Arg Gln Arg Val Leu His Trp Asp Leu Arg Gly Pro Gly Gly Gly 
    50                  55                  60                  


Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser Ala Gly Glu Gln Arg Val 
65                  70                  75                  80  


Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu Leu Ser Ala Ser Ala Phe 
                85                  90                  95      


Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val Glu Glu Thr Asp 
            100                 105                 110         


Ala Gly Leu Tyr Thr Cys Asn Leu His His His Tyr Cys His Leu Tyr 
        115                 120                 125             


Glu Ser Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro Pro Ala Thr 
    130                 135                 140                 


Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val Ala Arg Gly 
145                 150                 155                 160 


Ala Pro Ala Leu Leu Thr Cys Val Asn Arg Gly His Val Trp Thr Asp 
                165                 170                 175     


Arg His Val Glu Glu Ala Gln Gln Val Val His Trp Asp Arg Gln Pro 
            180                 185                 190         


Pro Gly Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp Leu Tyr Ala 
        195                 200                 205             


Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg Asp Arg Val 
    210                 215                 220                 


Ala Val Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser Leu Arg Ile 
225                 230                 235                 240 


Glu Pro Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys His Leu His 
                245                 250                 255     


His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe His Leu Thr Val 
            260                 265                 270         


Ala Glu Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro Gly Asn Gly 
        275                 280                 285             


Ser Ser His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu Ala Arg Gly 
    290                 295                 300                 


His Asn Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala His 
305                 310                 315             


<210>  3
<211>  942
<212>  DNA
<213>  Mus musculus

<400>  3
tctggcccga gcggtactgc tgccgcaagc tcaagcctcg tctctgaatc agttgtgtct       60

ctcgcggccg gaactcaggc ggtcctgagg tgtcaaagtc caaggatggt ttggacccaa      120

gatcgcttgc atgatcgaca aagagttgtg cactgggacc tcagcggtgg tcctggatca      180

caacgaagaa ggctggtgga catgtactca gccggagaac agcgcgttta cgagccacga      240

gaccgagatc gactcctttt gtcaccttct gcgttccatg acggcaactt ttctttgttg      300

ataagagccg tagatcgcgg agatgaagga gtttatacgt gtaaccttca ccaccattac      360

tgccatctcg atgaaagtct cgccgtacgg ctggaagtta cggaggaccc acttctttca      420

cgggcatatt gggatggcga gaaggaggtc ctggtcgttg ctcacggcgc accagccctg      480

atgacatgca tcaacagagc ccatgtttgg accgacaggc accttgaaga agcacaacaa      540

gttgtccatt gggaccgaca gctcccaggt gttagccatg atcgggccga tcgcttgctt      600

gacttgtatg ccagcgggga acggagggca tacggcccgc cttttcttcg ggatcgagtt      660

agcgtaaaca ctaacgcctt tgcacgcggt gacttcagcc ttcgcataga tgaactcgaa      720

cgagcagatg aaggaatata ctcctgccat ttgcatcatc attattgcgg cctgcatgag      780

cgaagggtat ttcacctcca agtgactgaa cctgcattcg agccaccagc gagggcctca      840

ccgggaaacg gctccggcca cagcagcgca ccgtctccgg acccgacttt gacacggggc      900

catagtataa taaacgtaat agttcctgag gaccataccc ac                         942


<210>  4
<211>  314
<212>  PRT
<213>  Mus musculus

<400>  4

Ser Gly Pro Ser Gly Thr Ala Ala Ala Ser Ser Ser Leu Val Ser Glu 
1               5                   10                  15      


Ser Val Val Ser Leu Ala Ala Gly Thr Gln Ala Val Leu Arg Cys Gln 
            20                  25                  30          


Ser Pro Arg Met Val Trp Thr Gln Asp Arg Leu His Asp Arg Gln Arg 
        35                  40                  45              


Val Val His Trp Asp Leu Ser Gly Gly Pro Gly Ser Gln Arg Arg Arg 
    50                  55                  60                  


Leu Val Asp Met Tyr Ser Ala Gly Glu Gln Arg Val Tyr Glu Pro Arg 
65                  70                  75                  80  


Asp Arg Asp Arg Leu Leu Leu Ser Pro Ser Ala Phe His Asp Gly Asn 
                85                  90                  95      


Phe Ser Leu Leu Ile Arg Ala Val Asp Arg Gly Asp Glu Gly Val Tyr 
            100                 105                 110         


Thr Cys Asn Leu His His His Tyr Cys His Leu Asp Glu Ser Leu Ala 
        115                 120                 125             


Val Arg Leu Glu Val Thr Glu Asp Pro Leu Leu Ser Arg Ala Tyr Trp 
    130                 135                 140                 


Asp Gly Glu Lys Glu Val Leu Val Val Ala His Gly Ala Pro Ala Leu 
145                 150                 155                 160 


Met Thr Cys Ile Asn Arg Ala His Val Trp Thr Asp Arg His Leu Glu 
                165                 170                 175     


Glu Ala Gln Gln Val Val His Trp Asp Arg Gln Leu Pro Gly Val Ser 
            180                 185                 190         


His Asp Arg Ala Asp Arg Leu Leu Asp Leu Tyr Ala Ser Gly Glu Arg 
        195                 200                 205             


Arg Ala Tyr Gly Pro Pro Phe Leu Arg Asp Arg Val Ser Val Asn Thr 
    210                 215                 220                 


Asn Ala Phe Ala Arg Gly Asp Phe Ser Leu Arg Ile Asp Glu Leu Glu 
225                 230                 235                 240 


Arg Ala Asp Glu Gly Ile Tyr Ser Cys His Leu His His His Tyr Cys 
                245                 250                 255     


Gly Leu His Glu Arg Arg Val Phe His Leu Gln Val Thr Glu Pro Ala 
            260                 265                 270         


Phe Glu Pro Pro Ala Arg Ala Ser Pro Gly Asn Gly Ser Gly His Ser 
        275                 280                 285             


Ser Ala Pro Ser Pro Asp Pro Thr Leu Thr Arg Gly His Ser Ile Ile 
    290                 295                 300                 


Asn Val Ile Val Pro Glu Asp His Thr His 
305                 310                 


<210>  5
<211>  933
<212>  DNA
<213>  Mus musculus

<400>  5
cccagcgggc ccatttcaac aatcaacccc tgtcctccat gcaaggagtg tcacaaatgc       60

ccaggtaagt cactaccaga gctccactcc caggagaatg gtaagtgctg taaaaatccc      120

tgtaatggag gataagccat gtacaaatcc atttccatct ctcctcatca gctcctaacc      180

tcgagggtgg accatccgtc ttcatcttcc ctccaaatat caaggatgta ctcatgatct      240

ccctgacacc caaggtcacg tgtgtggtgg tggatgtgag cgaggatgac ccagacgtcc      300

agatcagctg gtttgtgaac aacgtggaag tacacacagc tcagacacaa acccatagag      360

aggattacaa cagtactatc cgggtggtca gcaccctccc catccagcac caggactgga      420

tgagtggcaa ggagttcaaa tgcaaggtca acaacaaaga cctcccatca cccatcgaga      480

gaaccatctc aaaaattaaa ggtgggacct gcaggacaac tgcatggggg ctgggatggg      540

cataagaata aatgtctatg tggacagcct tccacttcag ccatgacctc tatgtatgtt      600

tctaacccca cagggctagt cagagctcca caagtataca tcttgccgcc accagcagag      660

cagttgtcca ggaaagatgt cagtctcact tgcctggtcg tgggcttcaa ccctggagac      720

atcagtgtgg agtggaccag caatgggcat acagaggaga actacaagga caccgcacca      780

gtcctggact ctgacggttc ttacttcata tatagcaagc tcaatatgaa aacaagcaag      840

tgggagaaaa cagattcctt ctcatgcaac gtgagacacg agggtctgaa aaattactac      900

ctgaagaaga ccatctcccg gtctccgggt aaa                                   933


<210>  6
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  6

Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu 
1               5                   10                  15      


Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe 
            20                  25                  30          


Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro 
        35                  40                  45              


Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
    50                  55                  60                  


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
65                  70                  75                  80  


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr 
                85                  90                  95      


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
            100                 105                 110         


Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
        115                 120                 125             


Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro 
    130                 135                 140                 


Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly 
                165                 170                 175     


His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp 
        195                 200                 205             


Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys 
    210                 215                 220                 


Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys 
225                 230                 235             


<210>  7
<211>  681
<212>  DNA
<213>  homo sapiens

<400>  7
gacaaaaccc atacatgccc accttgtcca gcaccagagc tgctgggagg accaagcgtg       60

ttcctgtttc cacccaagcc caaagatacc ctgatgatct cccggactcc cgaagtcacc      120

tgcgtggtcg tggacgtgtc tcacgaggac cccgaagtca agttcaactg gtacgtggac      180

ggggtcgagg tgcataatgc caagacaaaa cccagagagg aacagtacaa cagtacctat      240

agagtcgtgt cagtcctgac agtgctgcat caggattggc tgaacgggaa agagtataag      300

tgcaaagtga gtaataaggc tctgcctgca ccaatcgaga aaactatttc caaggccaaa      360

ggacagccca gggaacctca ggtgtacacc ctgcctccat cacgcgagga aatgacaaag      420

aaccaggtca gcctgacttg tctggtgaaa ggcttctatc cttctgacat cgctgtggag      480

tgggaaagta atgggcagcc agagaacaat tacaagacaa ctccccctgt cctggactct      540

gatggaagtt tctttctgta tagcaagctg accgtggata aatcccggtg gcagcagggc      600

aatgtcttta gctgttccgt gatgcacgaa gccctgcaca accactacac ccagaagagc      660

ctgagcctgt cacccggcaa a                                                681


<210>  8
<211>  227
<212>  PRT
<213>  homo sapiens

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  9
<211>  681
<212>  DNA
<213>  homo sapiens

<400>  9
gacaaaaccc atacatgccc accttgtcca gcaccagagc tgctgggagg accaagcgtg       60

ttcctgtttc cacccaagcc caaagatacc ctgatgatct cccggactcc cgaagtcacc      120

tgcgtggtcg tggacgtgtc tcacgaggac cccgaagtca agttcaactg gtacgtggac      180

ggggtcgagg tgcataatgc caagacaaaa cccagagagg aacagtacca gagtacctat      240

agagtcgtgt cagtcctgac agtgctgcat caggattggc tgaacgggaa agagtataag      300

tgcaaagtga gtaataaggc tctgcctgca ccaatcgaga aaactatttc caaggccaaa      360

ggacagccca gggaacctca ggtgtacacc ctgcctccat cacgcgagga aatgacaaag      420

aaccaggtca gcctgacttg tctggtgaaa ggcttctatc cttctgacat cgctgtggag      480

tgggaaagta atgggcagcc agagaacaat tacaagacaa ctccccctgt cctggactct      540

gatggaagtt tctttctgta tagcaagctg accgtggata aatcccggtg gcagcagggc      600

aatgtcttta gctgttccgt gatgcacgaa gccctgcaca accactacac ccagaagagc      660

ctgagcctgt cacccggcaa a                                                681


<210>  10
<211>  227
<212>  PRT
<213>  homo sapiens

<400>  10

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  11
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  11
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  12

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  13
tcaagcggca gcagcggcag ttcaggg                                           27


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  14

Ser Ser Gly Ser Ser Gly Ser Ser Gly 
1               5                   


<210>  15
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  15
atggggatcc ttcccagccc tgggatgcct gcgctgctct ccctcgtgag ccttctctcc       60

gtgctgctga tgggttgcgt agct                                              84


<210>  16
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artifiical Sequence

<400>  16

Met Gly Ile Leu Pro Ser Pro Gly Met Pro Ala Leu Leu Ser Leu Val 
1               5                   10                  15      


Ser Leu Leu Ser Val Leu Leu Met Gly Cys Val Ala 
            20                  25              


<210>  17
<211>  1968
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  17
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

atatcggtcc tgttgcatag cggctcctct gtcccggccg cagcgggatc aagcgtagtg      120

agcgagtcag cagtttcctg ggaagcgggg gcaagggctg ttctgaggtg tcagagccca      180

aggatggtgt ggacgcaaga ccggctccac gacaggcaaa gagtgcttca ctgggacctc      240

aggggacccg gtggtggccc agcacgccgg ctcctggacc tctatagcgc gggagaacaa      300

cgagtatacg aagctaggga cagaggaaga ctggagcttt cagccagtgc gttcgatgat      360

ggaaattttt cacttctgat ccgggctgtg gaagaaactg atgctggact gtatacttgt      420

aatctccacc atcactactg ccacctctat gagtcattgg ctgtcagact ggaagttacc      480

gatggcccgc ccgccacacc agcttactgg gatggcgaaa aagaagtact tgctgtcgcg      540

cgaggtgccc ctgcgctcct gacatgcgtc aacaggggtc acgtttggac tgatcggcac      600

gtcgaagagg ctcagcaagt agttcactgg gaccgccagc cgcctggcgt acctcacgat      660

agggccgacc gcctcttgga cctctacgcc tccggtgaaa ggagggccta tgggcctctg      720

ttcctcagag atagggttgc ggtgggcgca gatgcctttg aacgaggcga tttcagcctc      780

cgcattgagc ccctggaggt agccgatgag ggcacctact cctgtcatct gcatcatcat      840

tattgcggat tgcacgagag gagggtcttc cacttgactg tagctgaacc gcatgctgaa      900

ccgccacctc gcggatcacc cggaaacggt agcagtcatt ccggggctcc cgggccggat      960

ccgacattgg cacgagggca taacgtaata aatgtcatcg ttcccgagtc acgcgctcat     1020

gctagcgtta gatctcccag cgggcccatt tcaacaatca acccctgtcc tccatgcaag     1080

gagtgtcaca aatgcccagg taagtcacta ccagagctcc actcccagga gaatggtaag     1140

tgctgtaaaa atccctgtaa tggaggataa gccatgtaca aatccatttc catctctcct     1200

catcagctcc taacctcgag ggtggaccat ccgtcttcat cttccctcca aatatcaagg     1260

atgtactcat gatctccctg acacccaagg tcacgtgtgt ggtggtggat gtgagcgagg     1320

atgacccaga cgtccagatc agctggtttg tgaacaacgt ggaagtacac acagctcaga     1380

cacaaaccca tagagaggat tacaacagta ctatccgggt ggtcagcacc ctccccatcc     1440

agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac aaagacctcc     1500

catcacccat cgagagaacc atctcaaaaa ttaaaggtgg gacctgcagg acaactgcat     1560

gggggctggg atgggcataa gaataaatgt ctatgtggac agccttccac ttcagccatg     1620

acctctatgt atgtttctaa ccccacaggg ctagtcagag ctccacaagt atacatcttg     1680

ccgccaccag cagagcagtt gtccaggaaa gatgtcagtc tcacttgcct ggtcgtgggc     1740

ttcaaccctg gagacatcag tgtggagtgg accagcaatg ggcatacaga ggagaactac     1800

aaggacaccg caccagtcct ggactctgac ggttcttact tcatatatag caagctcaat     1860

atgaaaacaa gcaagtggga gaaaacagat tccttctcat gcaacgtgag acacgagggt     1920

ctgaaaaatt actacctgaa gaagaccatc tcccggtctc cgggtaaa                  1968


<210>  18
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  18

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ile Ser Val Leu Leu His Ser Gly Ser Ser Val Pro 
            20                  25                  30          


Ala Ala Ala Gly Ser Ser Val Val Ser Glu Ser Ala Val Ser Trp Glu 
        35                  40                  45              


Ala Gly Ala Arg Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp 
    50                  55                  60                  


Thr Gln Asp Arg Leu His Asp Arg Gln Arg Val Leu His Trp Asp Leu 
65                  70                  75                  80  


Arg Gly Pro Gly Gly Gly Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser 
                85                  90                  95      


Ala Gly Glu Gln Arg Val Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu 
            100                 105                 110         


Leu Ser Ala Ser Ala Phe Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg 
        115                 120                 125             


Ala Val Glu Glu Thr Asp Ala Gly Leu Tyr Thr Cys Asn Leu His His 
    130                 135                 140                 


His Tyr Cys His Leu Tyr Glu Ser Leu Ala Val Arg Leu Glu Val Thr 
145                 150                 155                 160 


Asp Gly Pro Pro Ala Thr Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val 
                165                 170                 175     


Leu Ala Val Ala Arg Gly Ala Pro Ala Leu Leu Thr Cys Val Asn Arg 
            180                 185                 190         


Gly His Val Trp Thr Asp Arg His Val Glu Glu Ala Gln Gln Val Val 
        195                 200                 205             


His Trp Asp Arg Gln Pro Pro Gly Val Pro His Asp Arg Ala Asp Arg 
    210                 215                 220                 


Leu Leu Asp Leu Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu 
225                 230                 235                 240 


Phe Leu Arg Asp Arg Val Ala Val Gly Ala Asp Ala Phe Glu Arg Gly 
                245                 250                 255     


Asp Phe Ser Leu Arg Ile Glu Pro Leu Glu Val Ala Asp Glu Gly Thr 
            260                 265                 270         


Tyr Ser Cys His Leu His His His Tyr Cys Gly Leu His Glu Arg Arg 
        275                 280                 285             


Val Phe His Leu Thr Val Ala Glu Pro His Ala Glu Pro Pro Pro Arg 
    290                 295                 300                 


Gly Ser Pro Gly Asn Gly Ser Ser His Ser Gly Ala Pro Gly Pro Asp 
305                 310                 315                 320 


Pro Thr Leu Ala Arg Gly His Asn Val Ile Asn Val Ile Val Pro Glu 
                325                 330                 335     


Ser Arg Ala His Ala Ser Val Arg Ser Pro Ser Gly Pro Ile Ser Thr 
            340                 345                 350         


Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro 
        355                 360                 365             


Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys 
    370                 375                 380                 


Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
                405                 410                 415     


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
            420                 425                 430         


Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His Gln Asp 
        435                 440                 445             


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
    450                 455                 460                 


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg 
465                 470                 475                 480 


Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg 
                485                 490                 495     


Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp 
            500                 505                 510         


Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys 
        515                 520                 525             


Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser 
    530                 535                 540                 


Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser 
545                 550                 555                 560 


Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr 
                565                 570                 575     


Ile Ser Arg Ser Pro Gly Lys 
            580             


<210>  19
<211>  1956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  19
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

atatcgtctg gcccgagcgg tactgctgcc gcaagctcaa gcctcgtctc tgaatcagtt      120

gtgtctctcg cggccggaac tcaggcggtc ctgaggtgtc aaagtccaag gatggtttgg      180

acccaagatc gcttgcatga tcgacaaaga gttgtgcact gggacctcag cggtggtcct      240

ggatcacaac gaagaaggct ggtggacatg tactcagccg gagaacagcg cgtttacgag      300

ccacgagacc gagatcgact ccttttgtca ccttctgcgt tccatgacgg caacttttct      360

ttgttgataa gagccgtaga tcgcggagat gaaggagttt atacgtgtaa ccttcaccac      420

cattactgcc atctcgatga aagtctcgcc gtacggctgg aagttacgga ggacccactt      480

ctttcacggg catattggga tggcgagaag gaggtcctgg tcgttgctca cggcgcacca      540

gccctgatga catgcatcaa cagagcccat gtttggaccg acaggcacct tgaagaagca      600

caacaagttg tccattggga ccgacagctc ccaggtgtta gccatgatcg ggccgatcgc      660

ttgcttgact tgtatgccag cggggaacgg agggcatacg gcccgccttt tcttcgggat      720

cgagttagcg taaacactaa cgcctttgca cgcggtgact tcagccttcg catagatgaa      780

ctcgaacgag cagatgaagg aatatactcc tgccatttgc atcatcatta ttgcggcctg      840

catgagcgaa gggtatttca cctccaagtg actgaacctg cattcgagcc accagcgagg      900

gcctcaccgg gaaacggctc cggccacagc agcgcaccgt ctccggaccc gactttgaca      960

cggggccata gtataataaa cgtaatagtt cctgaggacc atacccacgc tagcgttaga     1020

tctcccagcg ggcccatttc aacaatcaac ccctgtcctc catgcaagga gtgtcacaaa     1080

tgcccaggta agtcactacc agagctccac tcccaggaga atggtaagtg ctgtaaaaat     1140

ccctgtaatg gaggataagc catgtacaaa tccatttcca tctctcctca tcagctccta     1200

acctcgaggg tggaccatcc gtcttcatct tccctccaaa tatcaaggat gtactcatga     1260

tctccctgac acccaaggtc acgtgtgtgg tggtggatgt gagcgaggat gacccagacg     1320

tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca caaacccata     1380

gagaggatta caacagtact atccgggtgg tcagcaccct ccccatccag caccaggact     1440

ggatgagtgg caaggagttc aaatgcaagg tcaacaacaa agacctccca tcacccatcg     1500

agagaaccat ctcaaaaatt aaaggtggga cctgcaggac aactgcatgg gggctgggat     1560

gggcataaga ataaatgtct atgtggacag ccttccactt cagccatgac ctctatgtat     1620

gtttctaacc ccacagggct agtcagagct ccacaagtat acatcttgcc gccaccagca     1680

gagcagttgt ccaggaaaga tgtcagtctc acttgcctgg tcgtgggctt caaccctgga     1740

gacatcagtg tggagtggac cagcaatggg catacagagg agaactacaa ggacaccgca     1800

ccagtcctgg actctgacgg ttcttacttc atatatagca agctcaatat gaaaacaagc     1860

aagtgggaga aaacagattc cttctcatgc aacgtgagac acgagggtct gaaaaattac     1920

tacctgaaga agaccatctc ccggtctccg ggtaaa                               1956


<210>  20
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  20

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ile Ser Ser Gly Pro Ser Gly Thr Ala Ala Ala Ser 
            20                  25                  30          


Ser Ser Leu Val Ser Glu Ser Val Val Ser Leu Ala Ala Gly Thr Gln 
        35                  40                  45              


Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln Asp Arg 
    50                  55                  60                  


Leu His Asp Arg Gln Arg Val Val His Trp Asp Leu Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ser Gln Arg Arg Arg Leu Val Asp Met Tyr Ser Ala Gly Glu Gln 
                85                  90                  95      


Arg Val Tyr Glu Pro Arg Asp Arg Asp Arg Leu Leu Leu Ser Pro Ser 
            100                 105                 110         


Ala Phe His Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val Asp Arg 
        115                 120                 125             


Gly Asp Glu Gly Val Tyr Thr Cys Asn Leu His His His Tyr Cys His 
    130                 135                 140                 


Leu Asp Glu Ser Leu Ala Val Arg Leu Glu Val Thr Glu Asp Pro Leu 
145                 150                 155                 160 


Leu Ser Arg Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Val Val Ala 
                165                 170                 175     


His Gly Ala Pro Ala Leu Met Thr Cys Ile Asn Arg Ala His Val Trp 
            180                 185                 190         


Thr Asp Arg His Leu Glu Glu Ala Gln Gln Val Val His Trp Asp Arg 
        195                 200                 205             


Gln Leu Pro Gly Val Ser His Asp Arg Ala Asp Arg Leu Leu Asp Leu 
    210                 215                 220                 


Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Pro Phe Leu Arg Asp 
225                 230                 235                 240 


Arg Val Ser Val Asn Thr Asn Ala Phe Ala Arg Gly Asp Phe Ser Leu 
                245                 250                 255     


Arg Ile Asp Glu Leu Glu Arg Ala Asp Glu Gly Ile Tyr Ser Cys His 
            260                 265                 270         


Leu His His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe His Leu 
        275                 280                 285             


Gln Val Thr Glu Pro Ala Phe Glu Pro Pro Ala Arg Ala Ser Pro Gly 
    290                 295                 300                 


Asn Gly Ser Gly His Ser Ser Ala Pro Ser Pro Asp Pro Thr Leu Thr 
305                 310                 315                 320 


Arg Gly His Ser Ile Ile Asn Val Ile Val Pro Glu Asp His Thr His 
                325                 330                 335     


Ala Ser Val Arg Ser Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys 
            340                 345                 350         


Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly 
        355                 360                 365             


Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met 
    370                 375                 380                 


Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu 
385                 390                 395                 400 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
                405                 410                 415     


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile 
            420                 425                 430         


Arg Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
        435                 440                 445             


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile 
    450                 455                 460                 


Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val 
465                 470                 475                 480 


Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser 
                485                 490                 495     


Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu 
            500                 505                 510         


Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro 
        515                 520                 525             


Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met 
    530                 535                 540                 


Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg 
545                 550                 555                 560 


His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser 
                565                 570                 575     


Pro Gly Lys 
            


<210>  21
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  21
atggggatcc ttcccagccc tgggatgcct gcgctgctct ccctcgtgag ccttctctcc       60

gtgctgctga tgggttgcgt agctgaaacc ggttctggcc cgagcggtac tgctgccgca      120

agctcaagcc tcgtctctga atcagttgtg tctctcgcgg ccggaactca ggcggtcctg      180

aggtgtcaaa gtccaaggat ggtttggacc caagatcgct tgcatgatcg acaaagagtt      240

gtgcactggg acctcagcgg tggtcctgga tcacaacgaa gaaggctggt ggacatgtac      300

tcagccggag aacagcgcgt ttacgagcca cgagaccgag atcgactcct tttgtcacct      360

tctgcgttcc atgacggcaa cttttctttg ttgataagag ccgtagatcg cggagatgaa      420

ggagtttata cgtgtaacct tcaccaccat tactgccatc tcgatgaaag tctcgccgta      480

cggctggaag ttacggagga cccacttctt tcacgggcat attgggatgg cgagaaggag      540

gtcctggtcg ttgctcacgg cgcaccagcc ctgatgacat gcatcaacag agcccatgtt      600

tggaccgaca ggcaccttga agaagcacaa caagttgtcc attgggaccg acagctccca      660

ggtgttagcc atgatcgggc cgatcgcttg cttgacttgt atgccagcgg ggaacggagg      720

gcatacggcc cgccttttct tcgggatcga gttagcgtaa acactaacgc ctttgcacgc      780

ggtgacttca gccttcgcat agatgaactc gaacgagcag atgaaggaat atactcctgc      840

catttgcatc atcattattg cggcctgcat gagcgaaggg tatttcacct ccaagtgact      900

gaacctgcat tcgagccacc agcgagggcc tcaccgggaa acggctccgg ccacagcagc      960

gcaccgtctc cggacccgac tttgacacgg ggccatagta taataaacgt aatagttcct     1020

gaggaccata cccactcaag cggcagcagc ggcagttcag gggacaaaac ccatacatgc     1080

ccaccttgtc cagcaccaga gctgctggga ggaccaagcg tgttcctgtt tccacccaag     1140

cccaaagata ccctgatgat ctcccggact cccgaagtca cctgcgtggt cgtggacgtg     1200

tctcacgagg accccgaagt caagttcaac tggtacgtgg acggggtcga ggtgcataat     1260

gccaagacaa aacccagaga ggaacagtac aacagtacct atagagtcgt gtcagtcctg     1320

acagtgctgc atcaggattg gctgaacggg aaagagtata agtgcaaagt gagtaataag     1380

gctctgcctg caccaatcga gaaaactatt tccaaggcca aaggacagcc cagggaacct     1440

caggtgtaca ccctgcctcc atcacgcgag gaaatgacaa agaaccaggt cagcctgact     1500

tgtctggtga aaggcttcta tccttctgac atcgctgtgg agtgggaaag taatgggcag     1560

ccagagaaca attacaagac aactccccct gtcctggact ctgatggaag tttctttctg     1620

tatagcaagc tgaccgtgga taaatcccgg tggcagcagg gcaatgtctt tagctgttcc     1680

gtgatgcacg aagccctgca caaccactac acccagaaga gcctgagcct gtcacccggc     1740

aaa                                                                   1743


<210>  22
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  22

Met Gly Ile Leu Pro Ser Pro Gly Met Pro Ala Leu Leu Ser Leu Val 
1               5                   10                  15      


Ser Leu Leu Ser Val Leu Leu Met Gly Cys Val Ala Glu Thr Gly Ser 
            20                  25                  30          


Gly Pro Ser Gly Thr Ala Ala Ala Ser Ser Ser Leu Val Ser Glu Ser 
        35                  40                  45              


Val Val Ser Leu Ala Ala Gly Thr Gln Ala Val Leu Arg Cys Gln Ser 
    50                  55                  60                  


Pro Arg Met Val Trp Thr Gln Asp Arg Leu His Asp Arg Gln Arg Val 
65                  70                  75                  80  


Val His Trp Asp Leu Ser Gly Gly Pro Gly Ser Gln Arg Arg Arg Leu 
                85                  90                  95      


Val Asp Met Tyr Ser Ala Gly Glu Gln Arg Val Tyr Glu Pro Arg Asp 
            100                 105                 110         


Arg Asp Arg Leu Leu Leu Ser Pro Ser Ala Phe His Asp Gly Asn Phe 
        115                 120                 125             


Ser Leu Leu Ile Arg Ala Val Asp Arg Gly Asp Glu Gly Val Tyr Thr 
    130                 135                 140                 


Cys Asn Leu His His His Tyr Cys His Leu Asp Glu Ser Leu Ala Val 
145                 150                 155                 160 


Arg Leu Glu Val Thr Glu Asp Pro Leu Leu Ser Arg Ala Tyr Trp Asp 
                165                 170                 175     


Gly Glu Lys Glu Val Leu Val Val Ala His Gly Ala Pro Ala Leu Met 
            180                 185                 190         


Thr Cys Ile Asn Arg Ala His Val Trp Thr Asp Arg His Leu Glu Glu 
        195                 200                 205             


Ala Gln Gln Val Val His Trp Asp Arg Gln Leu Pro Gly Val Ser His 
    210                 215                 220                 


Asp Arg Ala Asp Arg Leu Leu Asp Leu Tyr Ala Ser Gly Glu Arg Arg 
225                 230                 235                 240 


Ala Tyr Gly Pro Pro Phe Leu Arg Asp Arg Val Ser Val Asn Thr Asn 
                245                 250                 255     


Ala Phe Ala Arg Gly Asp Phe Ser Leu Arg Ile Asp Glu Leu Glu Arg 
            260                 265                 270         


Ala Asp Glu Gly Ile Tyr Ser Cys His Leu His His His Tyr Cys Gly 
        275                 280                 285             


Leu His Glu Arg Arg Val Phe His Leu Gln Val Thr Glu Pro Ala Phe 
    290                 295                 300                 


Glu Pro Pro Ala Arg Ala Ser Pro Gly Asn Gly Ser Gly His Ser Ser 
305                 310                 315                 320 


Ala Pro Ser Pro Asp Pro Thr Leu Thr Arg Gly His Ser Ile Ile Asn 
                325                 330                 335     


Val Ile Val Pro Glu Asp His Thr His Ser Ser Gly Ser Ser Gly Ser 
            340                 345                 350         


Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        355                 360                 365             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    370                 375                 380                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
385                 390                 395                 400 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                405                 410                 415     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            420                 425                 430         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        435                 440                 445             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    450                 455                 460                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
465                 470                 475                 480 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                485                 490                 495     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            500                 505                 510         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        515                 520                 525             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    530                 535                 540                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
545                 550                 555                 560 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                565                 570                 575     


Leu Ser Pro Gly Lys 
            580     


<210>  23
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  23
atggggatcc ttcccagccc tgggatgcct gcgctgctct ccctcgtgag ccttctctcc       60

gtgctgctga tgggttgcgt agctgaaacc ggttctggcc cgagcggtac tgctgccgca      120

agctcaagcc tcgtctctga atcagttgtg tctctcgcgg ccggaactca ggcggtcctg      180

aggtgtcaaa gtccaaggat ggtttggacc caagatcgct tgcatgatcg acaaagagtt      240

gtgcactggg acctcagcgg tggtcctgga tcacaacgaa gaaggctggt ggacatgtac      300

tcagccggag aacagcgcgt ttacgagcca cgagaccgag atcgactcct tttgtcacct      360

tctgcgttcc atgacggcaa cttttctttg ttgataagag ccgtagatcg cggagatgaa      420

ggagtttata cgtgtaacct tcaccaccat tactgccatc tcgatgaaag tctcgccgta      480

cggctggaag ttacggagga cccacttctt tcacgggcat attgggatgg cgagaaggag      540

gtcctggtcg ttgctcacgg cgcaccagcc ctgatgacat gcatcaacag agcccatgtt      600

tggaccgaca ggcaccttga agaagcacaa caagttgtcc attgggaccg acagctccca      660

ggtgttagcc atgatcgggc cgatcgcttg cttgacttgt atgccagcgg ggaacggagg      720

gcatacggcc cgccttttct tcgggatcga gttagcgtaa acactaacgc ctttgcacgc      780

ggtgacttca gccttcgcat agatgaactc gaacgagcag atgaaggaat atactcctgc      840

catttgcatc atcattattg cggcctgcat gagcgaaggg tatttcacct ccaagtgact      900

gaacctgcat tcgagccacc agcgagggcc tcaccgggaa acggctccgg ccacagcagc      960

gcaccgtctc cggacccgac tttgacacgg ggccatagta taataaacgt aatagttcct     1020

gaggaccata cccactcaag cggcagcagc ggcagttcag gggacaaaac ccatacatgc     1080

ccaccttgtc cagcaccaga gctgctggga ggaccaagcg tgttcctgtt tccacccaag     1140

cccaaagata ccctgatgat ctcccggact cccgaagtca cctgcgtggt cgtggacgtg     1200

tctcacgagg accccgaagt caagttcaac tggtacgtgg acggggtcga ggtgcataat     1260

gccaagacaa aacccagaga ggaacagtac cagagtacct atagagtcgt gtcagtcctg     1320

acagtgctgc atcaggattg gctgaacggg aaagagtata agtgcaaagt gagtaataag     1380

gctctgcctg caccaatcga gaaaactatt tccaaggcca aaggacagcc cagggaacct     1440

caggtgtaca ccctgcctcc atcacgcgag gaaatgacaa agaaccaggt cagcctgact     1500

tgtctggtga aaggcttcta tccttctgac atcgctgtgg agtgggaaag taatgggcag     1560

ccagagaaca attacaagac aactccccct gtcctggact ctgatggaag tttctttctg     1620

tatagcaagc tgaccgtgga taaatcccgg tggcagcagg gcaatgtctt tagctgttcc     1680

gtgatgcacg aagccctgca caaccactac acccagaaga gcctgagcct gtcacccggc     1740

aaa                                                                   1743


<210>  24
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  24

Met Gly Ile Leu Pro Ser Pro Gly Met Pro Ala Leu Leu Ser Leu Val 
1               5                   10                  15      


Ser Leu Leu Ser Val Leu Leu Met Gly Cys Val Ala Glu Thr Gly Ser 
            20                  25                  30          


Gly Pro Ser Gly Thr Ala Ala Ala Ser Ser Ser Leu Val Ser Glu Ser 
        35                  40                  45              


Val Val Ser Leu Ala Ala Gly Thr Gln Ala Val Leu Arg Cys Gln Ser 
    50                  55                  60                  


Pro Arg Met Val Trp Thr Gln Asp Arg Leu His Asp Arg Gln Arg Val 
65                  70                  75                  80  


Val His Trp Asp Leu Ser Gly Gly Pro Gly Ser Gln Arg Arg Arg Leu 
                85                  90                  95      


Val Asp Met Tyr Ser Ala Gly Glu Gln Arg Val Tyr Glu Pro Arg Asp 
            100                 105                 110         


Arg Asp Arg Leu Leu Leu Ser Pro Ser Ala Phe His Asp Gly Asn Phe 
        115                 120                 125             


Ser Leu Leu Ile Arg Ala Val Asp Arg Gly Asp Glu Gly Val Tyr Thr 
    130                 135                 140                 


Cys Asn Leu His His His Tyr Cys His Leu Asp Glu Ser Leu Ala Val 
145                 150                 155                 160 


Arg Leu Glu Val Thr Glu Asp Pro Leu Leu Ser Arg Ala Tyr Trp Asp 
                165                 170                 175     


Gly Glu Lys Glu Val Leu Val Val Ala His Gly Ala Pro Ala Leu Met 
            180                 185                 190         


Thr Cys Ile Asn Arg Ala His Val Trp Thr Asp Arg His Leu Glu Glu 
        195                 200                 205             


Ala Gln Gln Val Val His Trp Asp Arg Gln Leu Pro Gly Val Ser His 
    210                 215                 220                 


Asp Arg Ala Asp Arg Leu Leu Asp Leu Tyr Ala Ser Gly Glu Arg Arg 
225                 230                 235                 240 


Ala Tyr Gly Pro Pro Phe Leu Arg Asp Arg Val Ser Val Asn Thr Asn 
                245                 250                 255     


Ala Phe Ala Arg Gly Asp Phe Ser Leu Arg Ile Asp Glu Leu Glu Arg 
            260                 265                 270         


Ala Asp Glu Gly Ile Tyr Ser Cys His Leu His His His Tyr Cys Gly 
        275                 280                 285             


Leu His Glu Arg Arg Val Phe His Leu Gln Val Thr Glu Pro Ala Phe 
    290                 295                 300                 


Glu Pro Pro Ala Arg Ala Ser Pro Gly Asn Gly Ser Gly His Ser Ser 
305                 310                 315                 320 


Ala Pro Ser Pro Asp Pro Thr Leu Thr Arg Gly His Ser Ile Ile Asn 
                325                 330                 335     


Val Ile Val Pro Glu Asp His Thr His Ser Ser Gly Ser Ser Gly Ser 
            340                 345                 350         


Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        355                 360                 365             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    370                 375                 380                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
385                 390                 395                 400 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                405                 410                 415     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
            420                 425                 430         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        435                 440                 445             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    450                 455                 460                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
465                 470                 475                 480 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                485                 490                 495     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            500                 505                 510         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        515                 520                 525             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    530                 535                 540                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
545                 550                 555                 560 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                565                 570                 575     


Leu Ser Pro Gly Lys 
            580     


<210>  25
<211>  343
<212>  PRT
<213>  homo sapiens

<400>  25

Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu Gln 
1               5                   10                  15      


Ser Ser Ala Val Leu Leu His Ser Ala Val Glu Glu Thr Asp Ala Gly 
            20                  25                  30          


Leu Tyr Thr Cys Asn Leu His His His Tyr Cys His Leu Tyr Glu Ser 
        35                  40                  45              


Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro Pro Ala Thr Pro Ala 
    50                  55                  60                  


Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val Ala Arg Gly Ala Pro 
65                  70                  75                  80  


Ala Leu Leu Thr Cys Val Asn Arg Gly His Val Trp Thr Asp Arg His 
                85                  90                  95      


Val Glu Glu Ala Gln Gln Val Val His Trp Asp Arg Gln Pro Pro Gly 
            100                 105                 110         


Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp Leu Tyr Ala Ser Gly 
        115                 120                 125             


Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg Asp Arg Val Ala Val 
    130                 135                 140                 


Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser Leu Arg Ile Glu Pro 
145                 150                 155                 160 


Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys His Leu His His His 
                165                 170                 175     


Tyr Cys Gly Leu His Glu Arg Arg Val Phe His Leu Thr Val Ala Glu 
            180                 185                 190         


Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro Gly Asn Gly Ser Ser 
        195                 200                 205             


His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu Ala Arg Gly His Asn 
    210                 215                 220                 


Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala His Phe Phe Gln Gln 
225                 230                 235                 240 


Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu Phe Ile Leu Leu Leu Val 
                245                 250                 255     


Thr Val Leu Leu Ala Ala Arg Arg Arg Arg Gly Gly Tyr Glu Tyr Ser 
            260                 265                 270         


Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys Asp Val Asn Leu Ala Glu 
        275                 280                 285             


Phe Ala Val Ala Ala Gly Asp Gln Met Leu Tyr Arg Ser Glu Asp Ile 
    290                 295                 300                 


Gln Leu Asp Tyr Lys Asn Asn Ile Leu Lys Glu Arg Ala Glu Leu Ala 
305                 310                 315                 320 


His Ser Pro Leu Pro Ala Lys Tyr Ile Asp Leu Asp Lys Asp Pro Ser 
                325                 330                 335     


Gly Leu Cys Pro Leu Gly Ala 
            340             


<210>  26
<211>  444
<212>  PRT
<213>  homo sapiens

<400>  26

Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu Gln 
1               5                   10                  15      


Ser Ser Ala Val Leu Leu His Ser Gly Ser Ser Val Pro Ala Ala Ala 
            20                  25                  30          


Gly Ser Ser Val Val Ser Glu Ser Ala Val Ser Trp Glu Ala Gly Ala 
        35                  40                  45              


Arg Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln Asp 
    50                  55                  60                  


Arg Leu His Asp Arg Gln Arg Val Leu His Trp Asp Leu Arg Gly Pro 
65                  70                  75                  80  


Gly Gly Gly Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser Ala Gly Glu 
                85                  90                  95      


Gln Arg Val Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu Leu Ser Ala 
            100                 105                 110         


Ser Ala Phe Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val Glu 
        115                 120                 125             


Glu Thr Asp Ala Gly Leu Tyr Thr Cys Asn Leu His His His Tyr Cys 
    130                 135                 140                 


His Leu Tyr Glu Ser Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro 
145                 150                 155                 160 


Pro Ala Thr Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val 
                165                 170                 175     


Ala Arg Gly Ala Pro Ala Leu Leu Thr Cys Val Asn Arg Gly His Val 
            180                 185                 190         


Trp Thr Asp Arg His Val Glu Glu Ala Gln Gln Val Val His Trp Asp 
        195                 200                 205             


Arg Gln Pro Pro Gly Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp 
    210                 215                 220                 


Leu Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg 
225                 230                 235                 240 


Asp Arg Val Ala Val Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser 
                245                 250                 255     


Leu Arg Ile Glu Pro Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys 
            260                 265                 270         


His Leu His His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe His 
        275                 280                 285             


Leu Thr Val Ala Glu Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro 
    290                 295                 300                 


Gly Asn Gly Ser Ser His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu 
305                 310                 315                 320 


Ala Arg Gly His Asn Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala 
                325                 330                 335     


His Phe Phe Gln Gln Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Val Thr Val Leu Leu Ala Ala Arg Arg Arg Arg Gly 
        355                 360                 365             


Gly Tyr Glu Tyr Ser Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys Asp 
    370                 375                 380                 


Val Asn Leu Ala Glu Phe Ala Val Ala Ala Gly Asp Gln Met Leu Tyr 
385                 390                 395                 400 


Arg Ser Glu Asp Ile Gln Leu Asp Tyr Lys Asn Asn Ile Leu Lys Glu 
                405                 410                 415     


Arg Ala Glu Leu Ala His Ser Pro Leu Pro Ala Lys Tyr Ile Asp Leu 
            420                 425                 430         


Asp Lys Asp Pro Ser Gly Leu Cys Pro Leu Gly Ala 
        435                 440                 


<210>  27
<211>  442
<212>  PRT
<213>  homo sapiens

<400>  27

Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu Gln 
1               5                   10                  15      


Ser Ser Ala Val Leu Leu His Ser Gly Ser Ser Val Pro Ala Ala Ala 
            20                  25                  30          


Gly Ser Ser Val Val Ser Glu Ser Ala Val Ser Trp Glu Ala Gly Ala 
        35                  40                  45              


Arg Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln Asp 
    50                  55                  60                  


Arg Leu His Asp Arg Gln Arg Val Leu His Trp Asp Leu Arg Gly Pro 
65                  70                  75                  80  


Gly Gly Gly Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser Ala Gly Glu 
                85                  90                  95      


Gln Arg Val Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu Leu Ser Ala 
            100                 105                 110         


Ser Ala Phe Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val Glu 
        115                 120                 125             


Glu Thr Asp Ala Gly Leu Tyr Thr Cys Asn Leu His His His Tyr Cys 
    130                 135                 140                 


His Leu Tyr Glu Ser Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro 
145                 150                 155                 160 


Pro Ala Thr Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val 
                165                 170                 175     


Ala Arg Gly Ala Pro Ala Leu Leu Thr Cys Val Asn Arg Gly His Val 
            180                 185                 190         


Trp Thr Asp Arg His Val Glu Glu Ala Gln Gln Val Val His Trp Asp 
        195                 200                 205             


Arg Gln Pro Pro Gly Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp 
    210                 215                 220                 


Leu Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg 
225                 230                 235                 240 


Asp Arg Val Ala Val Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser 
                245                 250                 255     


Leu Arg Ile Glu Pro Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys 
            260                 265                 270         


His Leu His His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe His 
        275                 280                 285             


Leu Thr Val Ala Glu Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro 
    290                 295                 300                 


Gly Asn Gly Ser Ser His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu 
305                 310                 315                 320 


Ala Arg Gly His Asn Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala 
                325                 330                 335     


His Phe Phe Gln Gln Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Val Thr Val Leu Leu Ala Ala Arg Arg Arg Arg Gly 
        355                 360                 365             


Gly Tyr Glu Tyr Ser Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys Asp 
    370                 375                 380                 


Val Asn Leu Ala Glu Phe Ala Val Ala Ala Gly Asp Gln Met Leu Tyr 
385                 390                 395                 400 


Arg Ser Glu Asp Ile Gln Leu Asp Tyr Lys Asn Asn Ile Leu Lys Glu 
                405                 410                 415     


Arg Ala Glu Leu Ala His Ser Pro Leu Pro Ala Lys Tyr Ile Asp Leu 
            420                 425                 430         


Asp Lys Gly Phe Arg Lys Glu Asn Cys Lys 
        435                 440         


<210>  28
<211>  433
<212>  PRT
<213>  homo sapiens

<400>  28

Met Ile Arg Cys Ala Ala Thr Gly Ser Ala Val Leu Leu His Ser Gly 
1               5                   10                  15      


Ser Ser Val Pro Ala Ala Ala Gly Ser Ser Val Val Ser Glu Ser Ala 
            20                  25                  30          


Val Ser Trp Glu Ala Gly Ala Arg Ala Val Leu Arg Cys Gln Ser Pro 
        35                  40                  45              


Arg Met Val Trp Thr Gln Asp Arg Leu His Asp Arg Gln Arg Val Leu 
    50                  55                  60                  


His Trp Asp Leu Arg Gly Pro Gly Gly Gly Pro Ala Arg Arg Leu Leu 
65                  70                  75                  80  


Asp Leu Tyr Ser Ala Gly Glu Gln Arg Val Tyr Glu Ala Arg Asp Arg 
                85                  90                  95      


Gly Arg Leu Glu Leu Ser Ala Ser Ala Phe Asp Asp Gly Asn Phe Ser 
            100                 105                 110         


Leu Leu Ile Arg Ala Val Glu Glu Thr Asp Ala Gly Leu Tyr Thr Cys 
        115                 120                 125             


Asn Leu His His His Tyr Cys His Leu Tyr Glu Ser Leu Ala Val Arg 
    130                 135                 140                 


Leu Glu Val Thr Asp Gly Pro Pro Ala Thr Pro Ala Tyr Trp Asp Gly 
145                 150                 155                 160 


Glu Lys Glu Val Leu Ala Val Ala Arg Gly Ala Pro Ala Leu Leu Thr 
                165                 170                 175     


Cys Val Asn Arg Gly His Val Trp Thr Asp Arg His Val Glu Glu Ala 
            180                 185                 190         


Gln Gln Val Val His Trp Asp Arg Gln Pro Pro Gly Val Pro His Asp 
        195                 200                 205             


Arg Ala Asp Arg Leu Leu Asp Leu Tyr Ala Ser Gly Glu Arg Arg Ala 
    210                 215                 220                 


Tyr Gly Pro Leu Phe Leu Arg Asp Arg Val Ala Val Gly Ala Asp Ala 
225                 230                 235                 240 


Phe Glu Arg Gly Asp Phe Ser Leu Arg Ile Glu Pro Leu Glu Val Ala 
                245                 250                 255     


Asp Glu Gly Thr Tyr Ser Cys His Leu His His His Tyr Cys Gly Leu 
            260                 265                 270         


His Glu Arg Arg Val Phe His Leu Thr Val Ala Glu Pro His Ala Glu 
        275                 280                 285             


Pro Pro Pro Arg Gly Ser Pro Gly Asn Gly Ser Ser His Ser Gly Ala 
    290                 295                 300                 


Pro Gly Pro Asp Pro Thr Leu Ala Arg Gly His Asn Val Ile Asn Val 
305                 310                 315                 320 


Ile Val Pro Glu Ser Arg Ala His Phe Phe Gln Gln Leu Gly Tyr Val 
                325                 330                 335     


Leu Ala Thr Leu Leu Leu Phe Ile Leu Leu Leu Val Thr Val Leu Leu 
            340                 345                 350         


Ala Ala Arg Arg Arg Arg Gly Gly Tyr Glu Tyr Ser Asp Gln Lys Ser 
        355                 360                 365             


Gly Lys Ser Lys Gly Lys Asp Val Asn Leu Ala Glu Phe Ala Val Ala 
    370                 375                 380                 


Ala Gly Asp Gln Met Leu Tyr Arg Ser Glu Asp Ile Gln Leu Asp Tyr 
385                 390                 395                 400 


Lys Asn Asn Ile Leu Lys Glu Arg Ala Glu Leu Ala His Ser Pro Leu 
                405                 410                 415     


Pro Ala Lys Tyr Ile Asp Leu Asp Lys Gly Phe Arg Lys Glu Asn Cys 
            420                 425                 430         


Lys 
    


<210>  29
<211>  341
<212>  PRT
<213>  homo sapiens

<400>  29

Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu Gln 
1               5                   10                  15      


Ser Ser Ala Val Leu Leu His Ser Ala Val Glu Glu Thr Asp Ala Gly 
            20                  25                  30          


Leu Tyr Thr Cys Asn Leu His His His Tyr Cys His Leu Tyr Glu Ser 
        35                  40                  45              


Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro Pro Ala Thr Pro Ala 
    50                  55                  60                  


Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val Ala Arg Gly Ala Pro 
65                  70                  75                  80  


Ala Leu Leu Thr Cys Val Asn Arg Gly His Val Trp Thr Asp Arg His 
                85                  90                  95      


Val Glu Glu Ala Gln Gln Val Val His Trp Asp Arg Gln Pro Pro Gly 
            100                 105                 110         


Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp Leu Tyr Ala Ser Gly 
        115                 120                 125             


Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg Asp Arg Val Ala Val 
    130                 135                 140                 


Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser Leu Arg Ile Glu Pro 
145                 150                 155                 160 


Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys His Leu His His His 
                165                 170                 175     


Tyr Cys Gly Leu His Glu Arg Arg Val Phe His Leu Thr Val Ala Glu 
            180                 185                 190         


Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro Gly Asn Gly Ser Ser 
        195                 200                 205             


His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu Ala Arg Gly His Asn 
    210                 215                 220                 


Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala His Phe Phe Gln Gln 
225                 230                 235                 240 


Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu Phe Ile Leu Leu Leu Val 
                245                 250                 255     


Thr Val Leu Leu Ala Ala Arg Arg Arg Arg Gly Gly Tyr Glu Tyr Ser 
            260                 265                 270         


Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys Asp Val Asn Leu Ala Glu 
        275                 280                 285             


Phe Ala Val Ala Ala Gly Asp Gln Met Leu Tyr Arg Ser Glu Asp Ile 
    290                 295                 300                 


Gln Leu Asp Tyr Lys Asn Asn Ile Leu Lys Glu Arg Ala Glu Leu Ala 
305                 310                 315                 320 


His Ser Pro Leu Pro Ala Lys Tyr Ile Asp Leu Asp Lys Gly Phe Arg 
                325                 330                 335     


Lys Glu Asn Cys Lys 
            340     


<210>  30
<211>  450
<212>  PRT
<213>  homo sapiens

<400>  30

Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu Gln 
1               5                   10                  15      


Ser Ser Ala Val Leu Leu His Ser Gly Ser Ser Val Pro Ala Ala Ala 
            20                  25                  30          


Gly Ser Ser Val Val Ser Glu Ser Ala Val Ser Trp Glu Ala Gly Ala 
        35                  40                  45              


Arg Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln Asp 
    50                  55                  60                  


Arg Leu His Asp Arg Gln Arg Val Leu His Trp Asp Leu Arg Gly Pro 
65                  70                  75                  80  


Gly Gly Gly Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser Ala Gly Glu 
                85                  90                  95      


Gln Arg Val Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu Leu Ser Ala 
            100                 105                 110         


Ser Ala Phe Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val Glu 
        115                 120                 125             


Glu Thr Asp Ala Gly Leu Tyr Thr Cys Asn Leu His His His Tyr Cys 
    130                 135                 140                 


His Leu Tyr Glu Ser Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro 
145                 150                 155                 160 


Pro Ala Thr Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val 
                165                 170                 175     


Ala Arg Gly Ala Pro Ala Leu Leu Thr Cys Val Asn Arg Gly His Val 
            180                 185                 190         


Trp Thr Asp Arg His Val Glu Glu Ala Gln Gln Val Val His Trp Asp 
        195                 200                 205             


Arg Gln Pro Pro Gly Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp 
    210                 215                 220                 


Leu Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg 
225                 230                 235                 240 


Asp Arg Val Ala Val Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser 
                245                 250                 255     


Leu Arg Ile Glu Pro Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys 
            260                 265                 270         


His Leu His His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe His 
        275                 280                 285             


Leu Thr Val Ala Glu Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro 
    290                 295                 300                 


Gly Asn Gly Ser Ser His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu 
305                 310                 315                 320 


Ala Arg Gly His Asn Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala 
                325                 330                 335     


His Phe Phe Gln Gln Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Val Thr Val Leu Leu Ala Ala Arg Arg Arg Arg Gly 
        355                 360                 365             


Gly Tyr Glu Tyr Ser Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys Asp 
    370                 375                 380                 


Val Asn Leu Ala Glu Phe Ala Val Ala Ala Gly Asp Gln Met Leu Tyr 
385                 390                 395                 400 


Arg Ser Glu Asp Ile Gln Leu Ala Ser Ser Pro Pro Thr Asp Tyr Lys 
                405                 410                 415     


Asn Asn Ile Leu Lys Glu Arg Ala Glu Leu Ala His Ser Pro Leu Pro 
            420                 425                 430         


Ala Lys Tyr Ile Asp Leu Asp Lys Asp Pro Ser Gly Leu Cys Pro Leu 
        435                 440                 445             


Gly Ala 
    450 


<210>  31
<211>  442
<212>  PRT
<213>  homo sapiens

<400>  31

Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu Gln 
1               5                   10                  15      


Ser Ser Ala Val Leu Leu His Ser Gly Ser Ser Val Pro Ala Ala Ala 
            20                  25                  30          


Gly Ser Ser Val Val Ser Glu Ser Ala Val Ser Trp Glu Ala Gly Ala 
        35                  40                  45              


Arg Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln Asp 
    50                  55                  60                  


Arg Leu His Asp Arg Gln Arg Val Leu His Trp Asp Leu Arg Gly Pro 
65                  70                  75                  80  


Gly Gly Gly Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser Ala Gly Glu 
                85                  90                  95      


Gln Arg Val Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu Leu Ser Ala 
            100                 105                 110         


Ser Ala Phe Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val Glu 
        115                 120                 125             


Glu Thr Asp Ala Gly Leu Tyr Thr Cys Asn Leu His His His Tyr Cys 
    130                 135                 140                 


His Leu Tyr Glu Ser Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro 
145                 150                 155                 160 


Pro Ala Thr Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val 
                165                 170                 175     


Ala Arg Gly Ala Pro Ala Leu Leu Thr Cys Val Asn Arg Gly His Val 
            180                 185                 190         


Trp Thr Asp Arg His Val Glu Glu Ala Gln Gln Val Val His Trp Asp 
        195                 200                 205             


Arg Gln Pro Pro Gly Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp 
    210                 215                 220                 


Leu Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg 
225                 230                 235                 240 


Asp Arg Val Ala Val Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser 
                245                 250                 255     


Leu Arg Ile Glu Pro Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys 
            260                 265                 270         


His Leu His His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe His 
        275                 280                 285             


Leu Thr Val Ala Glu Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro 
    290                 295                 300                 


Gly Asn Gly Ser Ser His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu 
305                 310                 315                 320 


Ala Arg Gly His Asn Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala 
                325                 330                 335     


His Phe Phe Gln Gln Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Val Thr Val Leu Leu Ala Ala Arg Arg Arg Arg Gly 
        355                 360                 365             


Gly Tyr Glu Tyr Ser Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys Asp 
    370                 375                 380                 


Val Asn Leu Ala Glu Phe Ala Val Ala Ala Gly Asp Gln Met Leu Tyr 
385                 390                 395                 400 


Arg Ser Glu Asp Ile Gln Leu Asp Tyr Lys Asn Asn Ile Leu Lys Glu 
                405                 410                 415     


Arg Ala Glu Leu Ala His Ser Pro Leu Pro Ala Lys Tyr Ile Asp Leu 
            420                 425                 430         


Asp Lys Gly Phe Arg Lys Glu Asn Cys Lys 
        435                 440         


<210>  32
<211>  2280
<212>  DNA
<213>  Mus musculus

<400>  32
agtcaagatg ggggaggcca agcagttgag cagcgcagtg ggcggggccc agacccggcc       60

cagggctccg tgatgtcagc gggtgctggc agggagaggg ggtcggctgt ttttctggag      120

agttagagct gagtaagaca aagcacgtcc cccgcaggcg ccatggagct gctgtcccgc      180

gtcctgctgt ggaaactgct gcttcttcag agctctgcag tcctgtcctc agggccttca      240

gggaccgcag cagccagcag ctctctggtg tctgagtctg tggtgagctt ggcagccgga      300

acccaggctg tgctacgctg ccagagcccc cgcatggtgt ggacccaaga ccggctgcat      360

gatcgccagc gcgtggtcca ctgggacctc agcgggggcc cgggcagcca acggcgccga      420

cttgtggata tgtattcggc gggtgaacag cgcgtgtacg agccgcgcga tcgcgaccgc      480

ctcctgctgt cgccttctgc tttccacgac ggcaacttct cgctgctcat tcgcgctgtg      540

gacagaggcg atgaaggggt gtacacctgc aacctgcacc atcactactg ccacctcgat      600

gagagcctgg ctgtgcgcct cgaggttaca gaggatcccc tattaagtcg cgcatactgg      660

gacggtgaga aggaagtgtt ggtggtggcc catggcgcgc cggcactgat gacctgcatc      720

aaccgtgcgc acgtgtggac tgaccgccat ttagaggagg cgcagcaggt ggtccattgg      780

gaccgacagc tacctggggt gtcacacgac cgcgccgacc gcctgcttga cctgtatgca      840

tctggcgagc gccgcgccta tgggccaccc ttcctgcgtg atcgcgtgtc agtgaacacc      900

aacgcttttg cacgcggtga cttctcccta cgcatcgatg agctggagcg agctgatgag      960

ggcatctatt cctgccacct gcaccatcac tactgtggcc tccacgagcg ccgagtcttc     1020

cacctacagg tcacagagcc tgcctttgag ccaccagctc gtgcttctcc tggcaatggg     1080

tctggtcaca gcagtgctcc tagcccagat cccaccctga cccgaggcca cagcatcatc     1140

aatgtcattg tcccagagga ccacacacat ttcttccagc aactgggcta tgtgttggcc     1200

acgctgctgc tcttcatctt gctgctcatc actgtagtcc tggctacacg atatcgtcac     1260

agcggaggat gcaagacgtc ggacaaaaaa gctgggaagt caaaggggaa ggatgtgaac     1320

atggtggagt ttgctgtagc cacaagggat caggctccat ataggactga ggacatccag     1380

ctagattaca aaaacaacat cctgaaggag agggctgagc tggcccatag tcctctgcct     1440

gccaaggatg tggatctgga taaagagttc aggaaggagt actgcaaata aatggaccct     1500

gagcttctgg ctgggccagc agctctgtat caaaggacat ctccctgacc ctcctgcggt     1560

attcctggct cttctcagcg gctggtccga cttacctaga aacttggcag agcagctgcc     1620

tgtactttgc ccttcctaga atcgccaccc ctcatcttgg tgagcaactg tgggttccct     1680

agagactctg gtatagtacg attgctgccc ttcacctgtg cccactgatg gttgtacccc     1740

caacttaaac acaacaaaga tcccttgtta atatccacca aatgcaaagt ccctcgtggc     1800

ctcttactgc tagggtcagg aagacactta aaaattccag ttaagactcc ctagccacca     1860

gttaaacaca ttagccattg tcctgggggg tcttcctgag ctgcattgtg cctgtgtact     1920

gttcagagcc ctgctgttat aggttctgac tcatgggccc gccttgctgc tttgggcaac     1980

ttgaggctag cccagggccc tttctctgct tctgattcct ttctgccgaa tgcctcccaa     2040

gagctacacc agcagttact gggtaccgta tgactcttgg ccttgacatc cctccctagg     2100

ctggagtctg gggttggggc cccatttgtc ctctgttttg gctgaagatg gggcgaagat     2160

ttggctgagt ggcctatgct gtcacatcaa acagctatca tttactccta cttgggaagt     2220

tttcatgtga caataaaaga tacatctgat ttttagtctt ggaaaaaaaa aaaaaaaaaa     2280


<210>  33
<211>  2534
<212>  DNA
<213>  homo sapiens

<400>  33
atgtcctcgg accttcttgt ccctccaagg gtgcggtcac cacccctccc caggcctgac       60

cggtgagggg ctgggcctct gctcccacac tgcccctccc cagcaggcca gcaacgatgg      120

gggaggccaa ggggcccggc aggagccaga gggggcggtc cccagaccgt agacaggccc      180

aggcctccgt gatgtcaccg cgggtgctaa ggagggggag ggggtagggc tgtttttctg      240

gagagagact tagagccgag tgggacaaag cctggggctg ggcgggggcc atggcgctgc      300

catcccgaat cctgctttgg aaacttgtgc ttctgcagag ctctgctgtt ctcctgcact      360

cagggtcctc ggtacccgcc gctgctggca gctccgtggt gtccgagtcc gcggtgagct      420

gggaggcggg cgcccgggcg gtgctgcgct gccagagccc gcgcatggtg tggacccagg      480

accggctgca cgaccgccag cgcgtgctcc actgggacct gcgcggcccc gggggtggcc      540

ccgcgcggcg cctgctggac ttgtactcgg cgggcgagca gcgcgtgtac gaggcgcggg      600

accgcggccg cctggagctc tcggcctcgg ccttcgacga cggcaacttc tcgctgctca      660

tccgcgcggt ggaggagacg gacgcggggc tgtacacctg caacctgcac catcactact      720

gccacctcta cgagagcctg gccgtccgcc tggaggtcac cgacggcccc ccggccaccc      780

ccgcctactg ggacggcgag aaggaggtgc tggcggtggc gcgcggcgca cccgcgcttc      840

tgacctgcgt gaaccgcggg cacgtgtgga ccgaccggca cgtggaggag gctcaacagg      900

tggtgcactg ggaccggcag ccgcccgggg tcccgcacga ccgcgcggac cgcctgctgg      960

acctctacgc gtcgggcgag cgccgcgcct acgggcccct ttttctgcgc gaccgcgtgg     1020

ctgtgggcgc ggatgccttt gagcgcggtg acttctcact gcgtatcgag ccgctggagg     1080

tcgccgacga gggcacctac tcctgccacc tgcaccacca ttactgtggc ctgcacgaac     1140

gccgcgtctt ccacctgacg gtcgccgaac cccacgcgga gccgcccccc cggggctctc     1200

cgggcaacgg ctccagccac agcggcgccc caggcccaga ccccacactg gcgcgcggcc     1260

acaacgtcat caatgtcatc gtccccgaga gccgagccca cttcttccag cagctgggct     1320

acgtgctggc cacgctgctg ctcttcatcc tgctactggt cactgtcctc ctggccgccc     1380

gcaggcgccg cggaggctac gaatactcgg accagaagtc gggaaagtca aaggggaagg     1440

atgttaactt ggcggagttc gctgtggctg caggggacca gatgctttac aggagtgagg     1500

acatccagct agattacaaa aacaacatcc tgaaggagag ggcggagctg gcccacagcc     1560

ccctgcctgc caagtacatc gacctagaca aagggttccg gaaggagaac tgcaaatagg     1620

gaggccctgg gctcctggct gggccagcag ctgcacctct cctgtctgtg ctcctcgggg     1680

catctcctga tgctccgggg ctcacccccc ttccagcggc tggtcccgct ttcctggaat     1740

ttggcctggg cgtatgcaga ggccgcctcc acacccctct cccaggggct tggtggcagc     1800

atagccccca cccctgcggc ctttgctcac gggtggccct gcccacccct ggcacaacca     1860

aaatcccact gatgcccatc atgccctcag acccttctgg gctctgcccg ctgggggcct     1920

gaagacattc ctggaggaca ctcccatcag aacctggcag ccccaaaact ggggtcagcc     1980

tcagggcagg agtcccactc ctccagggct ctgctcgtcc ggggctggga gatgttcctg     2040

gaggaggaca ctcccatcag aacttggcag ccttgaagtt ggggtcagcc tcggcaggag     2100

tcccactcct cctggggtgc tgcctgccac cgagagctcc cccacctgta ccaccatgtg     2160

ggactccagg caccatctgt tctccccagg gacctgctga cttgaatgcc agcccttgct     2220

cctctgtgtt gctttgggcc acctggggct gcaccccctg ccctttctct gccccatccc     2280

taccctagcc ttgctctcag ccaccttgat agtcactggg ctccctgtga cttctgaccc     2340

tgacacccct cccttggact ctgcctgggc tggagtctag ggctggggct acatttggct     2400

tctgtactgg ctgaggacag gggagggagt gaagttggtt tggggtggcc tgtgttgcca     2460

ctctcagcac cccacatttg catctgctgg tggacctgcc accatcacaa taaagtcccc     2520

atctgatttt taga                                                       2534


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic RNA

<400>  34
cttgtggata tgtattcggc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic RNA

<400>  35
tgtgcgcctc gaggttacag                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic RNA

<400>  36
gctgcatgat cgccagcgcg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic RNA

<400>  37
ggcgcggatg cctttgagcg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic RNA

<400>  38
gtccgcctgg aggtcaccga                                                   20


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  39
cttgtggata tgtattcggc g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  40
ctggtcgaca tgtacagcgc g                                                 21


<210>  41
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  41
ctggcgcccc ccgccggcac caccgacgcc gcgcacccgg ggcggtccgt ggtccccgcg       60

ttgcttcctc tgctggccgg gaccctgctg ctgctggaga cggccactgc tccc            114


<210>  42
<211>  105
<212>  DNA
<213>  Mus musculus

<400>  42
tacccatacg atgttccaga ttacgctacg tcctcaccat ccattggcgg cccaaacatg       60

actttactat tggccatgat catgtttgcg ttaaagatag ggtcg                      105


<210>  43
<211>  2534
<212>  DNA
<213>  Homo Sapiens

<400>  43
atgtcctcgg accttcttgt ccctccaagg gtgcggtcac cacccctccc caggcctgac       60

cggtgagggg ctgggcctct gctcccacac tgcccctccc cagcaggcca gcaacgatgg      120

gggaggccaa ggggcccggc aggagccaga gggggcggtc cccagaccgt agacaggccc      180

aggcctccgt gatgtcaccg cgggtgctaa ggagggggag ggggtagggc tgtttttctg      240

gagagagact tagagccgag tgggacaaag cctggggctg ggcgggggcc atggcgctgc      300

catcccgaat cctgctttgg aaacttgtgc ttctgcagag ctctgctgtt ctcctgcact      360

cagggtcctc ggtacccgcc gctgctggca gctccgtggt gtccgagtcc gcggtgagct      420

gggaggcggg cgcccgggcg gtgctgcgct gccagagccc gcgcatggtg tggacccagg      480

accggctgca cgaccgccag cgcgtgctcc actgggacct gcgcggcccc gggggtggcc      540

ccgcgcggcg cctgctggac ttgtactcgg cgggcgagca gcgcgtgtac gaggcgcggg      600

accgcggccg cctggagctc tcggcctcgg ccttcgacga cggcaacttc tcgctgctca      660

tccgcgcggt ggaggagacg gacgcggggc tgtacacctg caacctgcac catcactact      720

gccacctcta cgagagcctg gccgtccgcc tggaggtcac cgacggcccc ccggccaccc      780

ccgcctactg ggacggcgag aaggaggtgc tggcggtggc gcgcggcgca cccgcgcttc      840

tgacctgcgt gaaccgcggg cacgtgtgga ccgaccggca cgtggaggag gctcaacagg      900

tggtgcactg ggaccggcag ccgcccgggg tcccgcacga ccgcgcggac cgcctgctgg      960

acctctacgc gtcgggcgag cgccgcgcct acgggcccct ttttctgcgc gaccgcgtgg     1020

ctgtgggcgc ggatgccttt gagcgcggtg acttctcact gcgtatcgag ccgctggagg     1080

tcgccgacga gggcacctac tcctgccacc tgcaccacca ttactgtggc ctgcacgaac     1140

gccgcgtctt ccacctgacg gtcgccgaac cccacgcgga gccgcccccc cggggctctc     1200

cgggcaacgg ctccagccac agcggcgccc caggcccaga ccccacactg gcgcgcggcc     1260

acaacgtcat caatgtcatc gtccccgaga gccgagccca cttcttccag cagctgggct     1320

acgtgctggc cacgctgctg ctcttcatcc tgctactggt cactgtcctc ctggccgccc     1380

gcaggcgccg cggaggctac gaatactcgg accagaagtc gggaaagtca aaggggaagg     1440

atgttaactt ggcggagttc gctgtggctg caggggacca gatgctttac aggagtgagg     1500

acatccagct agattacaaa aacaacatcc tgaaggagag ggcggagctg gcccacagcc     1560

ccctgcctgc caagtacatc gacctagaca aagggttccg gaaggagaac tgcaaatagg     1620

gaggccctgg gctcctggct gggccagcag ctgcacctct cctgtctgtg ctcctcgggg     1680

catctcctga tgctccgggg ctcacccccc ttccagcggc tggtcccgct ttcctggaat     1740

ttggcctggg cgtatgcaga ggccgcctcc acacccctct cccaggggct tggtggcagc     1800

atagccccca cccctgcggc ctttgctcac gggtggccct gcccacccct ggcacaacca     1860

aaatcccact gatgcccatc atgccctcag acccttctgg gctctgcccg ctgggggcct     1920

gaagacattc ctggaggaca ctcccatcag aacctggcag ccccaaaact ggggtcagcc     1980

tcagggcagg agtcccactc ctccagggct ctgctcgtcc ggggctggga gatgttcctg     2040

gaggaggaca ctcccatcag aacttggcag ccttgaagtt ggggtcagcc tcggcaggag     2100

tcccactcct cctggggtgc tgcctgccac cgagagctcc cccacctgta ccaccatgtg     2160

ggactccagg caccatctgt tctccccagg gacctgctga cttgaatgcc agcccttgct     2220

cctctgtgtt gctttgggcc acctggggct gcaccccctg ccctttctct gccccatccc     2280

taccctagcc ttgctctcag ccaccttgat agtcactggg ctccctgtga cttctgaccc     2340

tgacacccct cccttggact ctgcctgggc tggagtctag ggctggggct acatttggct     2400

tctgtactgg ctgaggacag gggagggagt gaagttggtt tggggtggcc tgtgttgcca     2460

ctctcagcac cccacatttg catctgctgg tggacctgcc accatcacaa taaagtcccc     2520

atctgatttt taga                                                       2534


<210>  44
<211>  2008
<212>  DNA
<213>  Homo Sapiens

<400>  44
acttagagcc gagtgggaca aagcctgggg ctgggcgggg gccatggcgc tgccatcccg       60

aatcctgctt tggaaacttg tgcttctgca gagctctgct gttctcctgc actcagggtc      120

ctcggtaccc gccgctgctg gcagctccgt ggtgtccgag tccgcggtga gctgggaggc      180

gggcgcccgg gcggtgctgc gctgccagag cccgcgcatg gtgtggaccc aggaccggct      240

gcacgaccgc cagcgcgtgc tccactggga cctgcgcggc cccgggggtg gccccgcgcg      300

gcgcctgctg gacttgtact cggcgggcga gcagcgcgtg tacgaggcgc gggaccgcgg      360

ccgcctggag ctctcggcct cggccttcga cgacggcaac ttctcgctgc tcatccgcgc      420

ggtggaggag acggacgcgg ggctgtacac ctgcaacctg caccatcact actgccacct      480

ctacgagagc ctggccgtcc gcctggaggt caccgacggc cccccggcca cccccgccta      540

ctgggacggc gagaaggagg tgctggcggt ggcgcgcggc gcacccgcgc ttctgacctg      600

cgtgaaccgc gggcacgtgt ggaccgaccg gcacgtggag gaggctcaac aggtggtgca      660

ctgggaccgg cagccgcccg gggtcccgca cgaccgcgcg gaccgcctgc tggacctcta      720

cgcgtcgggc gagcgccgcg cctacgggcc cctttttctg cgcgaccgcg tggctgtggg      780

cgcggatgcc tttgagcgcg gtgacttctc actgcgtatc gagccgctgg aggtcgccga      840

cgagggcacc tactcctgcc acctgcacca ccattactgt ggcctgcacg aacgccgcgt      900

cttccacctg acggtcgccg aaccccacgc ggagccgccc ccccggggct ctccgggcaa      960

cggctccagc cacagcggcg ccccaggccc agaccccaca ctggcgcgcg gccacaacgt     1020

catcaatgtc atcgtccccg agagccgagc ccacttcttc cagcagctgg gctacgtgct     1080

ggccacgctg ctgctcttca tcctgctact ggtcactgtc ctcctggccg cccgcaggcg     1140

ccgcggaggc tacgaatact cggaccagaa gtcgggaaag tcaaagggga aggatgttaa     1200

cttggcggag ttcgctgtgg ctgcagggga ccagatgctt tacaggagtg aggacatcca     1260

gctagcctcc tctcctccca cagattacaa aaacaacatc ctgaaggaga gggcggagct     1320

ggcccacagc cccctgcctg ccaagtacat cgacctagac aaagaccctt ctgggctctg     1380

cccgctgggg gcctgaagac attcctggag gacactccca tcagaacctg gcagccccaa     1440

aactggggtc agcctcaggg caggagtccc actcctccag ggctctgctc gtccggggct     1500

gggagatgtt cctggaggag gacactccca tcagaacttg gcagccttga agttggggtc     1560

agcctcggca ggagtcccac tcctcctggg gtgctgcctg ccaccgagag ctcccccacc     1620

tgtaccacca tgtgggactc caggcaccat ctgttctccc cagggacctg ctgacttgaa     1680

tgccagccct tgctcctctg tgttgctttg ggccacctgg ggctgcaccc cctgcccttt     1740

ctctgcccca tccctaccct agccttgctc tcagccacct tgatagtcac tgggctccct     1800

gtgacttctg accctgacac ccctcccttg gactctgcct gggctggagt ctagggctgg     1860

ggctacattt ggcttctgta ctggctgagg acaggggagg gagtgaagtt ggtttggggt     1920

ggcctgtgtt gccactctca gcaccccaca tttgcatctg ctggtggacc tgccaccatc     1980

acaataaagt ccccatctga tttttaga                                        2008


<210>  45
<211>  2231
<212>  DNA
<213>  Homo sapiens

<400>  45
atgtcctcgg accttcttgt ccctccaagg gtgcggtcac cacccctccc caggcctgac       60

cggtgagggg ctgggcctct gctcccacac tgcccctccc cagcaggcca gcaacgatgg      120

gggaggccaa ggggcccggc aggagccaga gggggcggtc cccagaccgt agacaggccc      180

aggcctccgt gatgtcaccg cgggtgctaa ggagggggag ggggtagggc tgtttttctg      240

gagagagact tagagccgag tgggacaaag cctggggctg ggcgggggcc atggcgctgc      300

catcccgaat cctgctttgg aaacttgtgc ttctgcagag ctctgctgtt ctcctgcact      360

cagcggtgga ggagacggac gcggggctgt acacctgcaa cctgcaccat cactactgcc      420

acctctacga gagcctggcc gtccgcctgg aggtcaccga cggccccccg gccacccccg      480

cctactggga cggcgagaag gaggtgctgg cggtggcgcg cggcgcaccc gcgcttctga      540

cctgcgtgaa ccgcgggcac gtgtggaccg accggcacgt ggaggaggct caacaggtgg      600

tgcactggga ccggcagccg cccggggtcc cgcacgaccg cgcggaccgc ctgctggacc      660

tctacgcgtc gggcgagcgc cgcgcctacg ggcccctttt tctgcgcgac cgcgtggctg      720

tgggcgcgga tgcctttgag cgcggtgact tctcactgcg tatcgagccg ctggaggtcg      780

ccgacgaggg cacctactcc tgccacctgc accaccatta ctgtggcctg cacgaacgcc      840

gcgtcttcca cctgacggtc gccgaacccc acgcggagcc gcccccccgg ggctctccgg      900

gcaacggctc cagccacagc ggcgccccag gcccagaccc cacactggcg cgcggccaca      960

acgtcatcaa tgtcatcgtc cccgagagcc gagcccactt cttccagcag ctgggctacg     1020

tgctggccac gctgctgctc ttcatcctgc tactggtcac tgtcctcctg gccgcccgca     1080

ggcgccgcgg aggctacgaa tactcggacc agaagtcggg aaagtcaaag gggaaggatg     1140

ttaacttggc ggagttcgct gtggctgcag gggaccagat gctttacagg agtgaggaca     1200

tccagctaga ttacaaaaac aacatcctga aggagagggc ggagctggcc cacagccccc     1260

tgcctgccaa gtacatcgac ctagacaaag ggttccggaa ggagaactgc aaatagggag     1320

gccctgggct cctggctggg ccagcagctg cacctctcct gtctgtgctc ctcggggcat     1380

ctcctgatgc tccggggctc accccccttc cagcggctgg tcccgctttc ctggaatttg     1440

gcctgggcgt atgcagaggc cgcctccaca cccctctccc aggggcttgg tggcagcata     1500

gcccccaccc ctgcggcctt tgctcacggg tggccctgcc cacccctggc acaaccaaaa     1560

tcccactgat gcccatcatg ccctcagacc cttctgggct ctgcccgctg ggggcctgaa     1620

gacattcctg gaggacactc ccatcagaac ctggcagccc caaaactggg gtcagcctca     1680

gggcaggagt cccactcctc cagggctctg ctcgtccggg gctgggagat gttcctggag     1740

gaggacactc ccatcagaac ttggcagcct tgaagttggg gtcagcctcg gcaggagtcc     1800

cactcctcct ggggtgctgc ctgccaccga gagctccccc acctgtacca ccatgtggga     1860

ctccaggcac catctgttct ccccagggac ctgctgactt gaatgccagc ccttgctcct     1920

ctgtgttgct ttgggccacc tggggctgca ccccctgccc tttctctgcc ccatccctac     1980

cctagccttg ctctcagcca ccttgatagt cactgggctc cctgtgactt ctgaccctga     2040

cacccctccc ttggactctg cctgggctgg agtctagggc tggggctaca tttggcttct     2100

gtactggctg aggacagggg agggagtgaa gttggtttgg ggtggcctgt gttgccactc     2160

tcagcacccc acatttgcat ctgctggtgg acctgccacc atcacaataa agtccccatc     2220

tgatttttag a                                                          2231


<210>  46
<211>  2731
<212>  DNA
<213>  Homo sapiens

<400>  46
aagaaggctg gcggtgtttc ctcttagagg ggagaaactc agcctgggta ggagacccag       60

ccccacgcag ggaaaactgt gctaacgctt ccgatgtgcg tggcaggtgc ggcggcggcg      120

aatacggttt gtcctcgagc ctaaccctgt ctgtgttggt gtcagcagtg gcccccctac      180

cacacacaca gggtccctgg cgtcccaaga ccactcctgg cagccccgcc actggctgcg      240

cctggaagcc gcgtcctcag gcctcgcctg gcatttgctg tcacagaggt tgcttccttg      300

ggtccgtccg tcctcgcccc tccagcctgg gcgccccccg acccctgtct cattccctcc      360

accacatgca gcacagtcca ggaggctggg gtccaagagg gccatggctg gcacccggct      420

tagtgctgag tccccagtgc ccagcaagcc tggcacccag gaggtggtca gcaaacgctt      480

ctgaacgaca ggaagtggga ctcttcagcc atcgatgatc cgctgtgcgg ccacaggctc      540

tgctgttctc ctgcactcag ggtcctcggt acccgccgct gctggcagct ccgtggtgtc      600

cgagtccgcg gtgagctggg aggcgggcgc ccgggcggtg ctgcgctgcc agagcccgcg      660

catggtgtgg acccaggacc ggctgcacga ccgccagcgc gtgctccact gggacctgcg      720

cggccccggg ggtggccccg cgcggcgcct gctggacttg tactcggcgg gcgagcagcg      780

cgtgtacgag gcgcgggacc gcggccgcct ggagctctcg gcctcggcct tcgacgacgg      840

caacttctcg ctgctcatcc gcgcggtgga ggagacggac gcggggctgt acacctgcaa      900

cctgcaccat cactactgcc acctctacga gagcctggcc gtccgcctgg aggtcaccga      960

cggccccccg gccacccccg cctactggga cggcgagaag gaggtgctgg cggtggcgcg     1020

cggcgcaccc gcgcttctga cctgcgtgaa ccgcgggcac gtgtggaccg accggcacgt     1080

ggaggaggct caacaggtgg tgcactggga ccggcagccg cccggggtcc cgcacgaccg     1140

cgcggaccgc ctgctggacc tctacgcgtc gggcgagcgc cgcgcctacg ggcccctttt     1200

tctgcgcgac cgcgtggctg tgggcgcgga tgcctttgag cgcggtgact tctcactgcg     1260

tatcgagccg ctggaggtcg ccgacgaggg cacctactcc tgccacctgc accaccatta     1320

ctgtggcctg cacgaacgcc gcgtcttcca cctgacggtc gccgaacccc acgcggagcc     1380

gcccccccgg ggctctccgg gcaacggctc cagccacagc ggcgccccag gcccagaccc     1440

cacactggcg cgcggccaca acgtcatcaa tgtcatcgtc cccgagagcc gagcccactt     1500

cttccagcag ctgggctacg tgctggccac gctgctgctc ttcatcctgc tactggtcac     1560

tgtcctcctg gccgcccgca ggcgccgcgg aggctacgaa tactcggacc agaagtcggg     1620

aaagtcaaag gggaaggatg ttaacttggc ggagttcgct gtggctgcag gggaccagat     1680

gctttacagg agtgaggaca tccagctaga ttacaaaaac aacatcctga aggagagggc     1740

ggagctggcc cacagccccc tgcctgccaa gtacatcgac ctagacaaag ggttccggaa     1800

ggagaactgc aaatagggag gccctgggct cctggctggg ccagcagctg cacctctcct     1860

gtctgtgctc ctcggggcat ctcctgatgc tccggggctc accccccttc cagcggctgg     1920

tcccgctttc ctggaatttg gcctgggcgt atgcagaggc cgcctccaca cccctctccc     1980

aggggcttgg tggcagcata gcccccaccc ctgcggcctt tgctcacggg tggccctgcc     2040

cacccctggc acaaccaaaa tcccactgat gcccatcatg ccctcagacc cttctgggct     2100

ctgcccgctg ggggcctgaa gacattcctg gaggacactc ccatcagaac ctggcagccc     2160

caaaactggg gtcagcctca gggcaggagt cccactcctc cagggctctg ctcgtccggg     2220

gctgggagat gttcctggag gaggacactc ccatcagaac ttggcagcct tgaagttggg     2280

gtcagcctcg gcaggagtcc cactcctcct ggggtgctgc ctgccaccga gagctccccc     2340

acctgtacca ccatgtggga ctccaggcac catctgttct ccccagggac ctgctgactt     2400

gaatgccagc ccttgctcct ctgtgttgct ttgggccacc tggggctgca ccccctgccc     2460

tttctctgcc ccatccctac cctagccttg ctctcagcca ccttgatagt cactgggctc     2520

cctgtgactt ctgaccctga cacccctccc ttggactctg cctgggctgg agtctagggc     2580

tggggctaca tttggcttct gtactggctg aggacagggg agggagtgaa gttggtttgg     2640

ggtggcctgt gttgccactc tcagcacccc acatttgcat ctgctggtgg acctgccacc     2700

atcacaataa agtccccatc tgatttttag a                                    2731


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  47
tcgacgcgcc atctttaa                                                     18


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  48
atcgaatgca ccgcacact                                                    19


<210>  49
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  49
accagcctgc acccactcct cagac                                             25


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  50
gtggagtcat actggaacat gtag                                              24


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  51
tgcaaatggc agccctggtg                                                   20


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  52

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  53
<211>  44
<212>  PRT
<213>  Mus musculus

<400>  53

Trp Thr Gln Asp Arg Leu His Asp Arg Gln Arg Val Val His Trp Asp 
1               5                   10                  15      


Leu Ser Gly Gly Pro Gly Ser Gln Arg Arg Arg Leu Val Asp Met Tyr 
            20                  25                  30          


Ser Ala Gly Glu Gln Arg Val Tyr Glu Pro Arg Asp 
        35                  40                  


<210>  54
<211>  60
<212>  PRT
<213>  Bovine

<400>  54

Trp Thr Gln Asp Arg Leu His Asp Arg Gln Arg Val Val His Trp Asp 
1               5                   10                  15      


Leu Ser Gly Ser Lys Ala Gly Gly Pro Ala Arg Arg Leu Val Asp Met 
            20                  25                  30          


Tyr Ser Thr Gly Glu Gln Arg Val Gly Glu Gln Arg Leu Gly Glu Gln 
        35                  40                  45              


Arg Val Gly Glu Gln Arg Val Tyr Glu Pro Arg Asp 
    50                  55                  60  


