                         SEQUENCE LISTING

<110>  ImmuNext, Inc.
       Amgen Inc.
 
<120>  ANTI-MCT1 ANTIBODIES AND USES THEREOF

<130>  43260.4213

<160>  533   

<170>  PatentIn version 3.5

<210>  1
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human MCT1 amino acid sequence

<400>  1

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
    210                 215                 220                 


Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
225                 230                 235                 240 


Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                245                 250                 255     


Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
            260                 265                 270         


Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
        275                 280                 285             


Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
    290                 295                 300                 


Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
305                 310                 315                 320 


Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                325                 330                 335     


Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
            340                 345                 350         


Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
        355                 360                 365             


Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
    370                 375                 380                 


Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
385                 390                 395                 400 


Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                405                 410                 415     


Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
            420                 425                 430         


Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
        435                 440                 445             


Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu 
    450                 455                 460                 


Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala 
465                 470                 475                 480 


Ala Glu Ser Pro Asp Gln Lys Asp Thr Asp Gly Gly Pro Lys Glu Glu 
                485                 490                 495     


Glu Ser Pro Val 
            500 


<210>  2
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)  VH

<400>  2

Gln Val Gln Leu Lys Ala Thr Gly Pro Gly Leu Val Gln Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Lys Thr Asp Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125     


<210>  3
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)  VL

<400>  3

Asn Ile His Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)   VH CDR1

<400>  4

Gly Phe Ser Leu Thr Asn Tyr His 
1               5               


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)   VH CDR2

<400>  5

Ile Arg Ser Ser Gly Asn Thr 
1               5           


<210>  6
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)   VH CDR3

<400>  6

Ala Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr 
1               5                   10                  15      


Val Met Asp Ala Trp Gly 
            20          


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)  VL CDR1

<400>  7

Gln Asn Ile Asn Asn Tyr 
1               5       


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)  VL CDR2

<400>  8

Asn Arg His 
1           


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCT1 Ab1 (INX310)  VL CDR3

<400>  9

Tyr Gln Tyr Ser Asp Gly Tyr Thr 
1               5               


<210>  10
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >INX310_VH

<400>  10

Gln Val Gln Leu Lys Ala Thr Gly Pro Gly Leu Val Gln Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Lys Thr Asp Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125     


<210>  11
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >INX310_VL

<400>  11

Asn Ile His Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  12
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2 (INX352)

<400>  12

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >INX352|INX356|INX364_VL

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  14
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3 (INX356)

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  15
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >INX352|INX356|INX364_VL

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  16
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4 (INX364)

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >INX352|INX356|INX364_VL

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  18
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  silent IgG1 (constant)

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE HEAVY CHAIN POLYPEPTIDE

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr 
        115                 120 


<210>  20
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) HEAVY CHAIN POLYPEPTIDE

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  21
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE HEAVY CHAIN POLYPEPTIDE

<400>  21

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  22
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) HEAVY CHAIN POLYPEPTIDE

<400>  22

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  23
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE HEAVY CHAIN POLYPEPTIDE

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  24
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) HEAVY CHAIN POLYPEPTIDE

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  25
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE HEAVY CHAIN POLYPEPTIDE

<400>  25

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  26
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) HEAVY CHAIN POLYPEPTIDE

<400>  26

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  27
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE HEAVY CHAIN POLYPEPTIDE

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  28
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) HEAVY CHAIN POLYPEPTIDE

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  29
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE HEAVY CHAIN POLYPEPTIDE

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  30
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) HEAVY CHAIN POLYPEPTIDE

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  31
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE HEAVY CHAIN POLYPEPTIDE

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  32
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) HEAVY CHAIN POLYPEPTIDE

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  33
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE LIGHT CHAIN POLYPEPTIDE

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  34
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED Ab1 (INX310) LIGHT CHAIN POLYPEPTIDE

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  35
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE LIGHT CHAIN POLYPEPTIDE

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  36
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) LIGHT CHAIN POLYPEPTIDE

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  37
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310)  VARIABLE LIGHT CHAIN POLYPEPTIDE

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  38
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) LIGHT CHAIN POLYPEPTIDE

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  39
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310)  VARIABLE LIGHT CHAIN POLYPEPTIDE

<400>  39

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  40
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) LIGHT CHAIN POLYPEPTIDE

<400>  40

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  41
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE LIGHT CHAIN POLYPEPTIDE

<400>  41

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  42
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED Ab1 (INX310) LIGHT CHAIN POLYPEPTIDE

<400>  42

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  43
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) VARIABLE LIGHT CHAIN POLYPEPTIDE

<400>  43

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  44
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMANIZED  Ab1 (INX310) LIGHT CHAIN POLYPEPTIDE

<400>  44

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  45
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5 (INX402)

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  46
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >LC

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  47
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6 (INX403)

<400>  47

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  48
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  49
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7 (INX404)

<400>  49

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Arg His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  50
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  51
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8 (INX405)

<400>  51

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Phe Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  52
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  53
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9 (INX406)

<400>  53

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Lys Trp Ile His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  54
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  55
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab10 (INX407)

<400>  55

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Met 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  56
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  57
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11 (INX408)

<400>  57

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  58
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  59
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12 (INX409)

<400>  59

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Ile His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  60
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  61
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13 (INX410)

<400>  61

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Trp Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  62
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  63
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14 (INX411)

<400>  63

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  64
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  65
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15 (INX412)

<400>  65

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Trp Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  66
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  67
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab16 (INX413)

<400>  67

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Phe Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  68
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  69
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17 (INX414)

<400>  69

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  70
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  71
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18 (INX415)

<400>  71

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Met His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL SEQ ID NO:72

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  73
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19 (INX416)

<400>  73

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Trp Val His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  74
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  75
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20 (INX417)

<400>  75

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  76
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  77
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21 (INX418)

<400>  77

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  78
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  79
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22 (INX419)

<400>  79

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Ser Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  80
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  81
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23 (NX420)

<400>  81

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Phe Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  82
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  83
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24 (INX421)

<400>  83

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Ile His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  84
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  85
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25 (INX422)

<400>  85

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  86
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  87
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26 (INX423)

<400>  87

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Trp Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  88
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  89
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27 (INX424)

<400>  89

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Met His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  90
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  91
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28 (INX425)

<400>  91

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Trp Val His Gly Thr Tyr Phe Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  92
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  93
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29 (INX426)

<400>  93

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  94
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  95
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab30 (INX427)

<400>  95

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Ser Tyr Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  96
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  97
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab31 (INX428)

<400>  97

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  98
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  98

Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Asn 
            20                  25                  30          


Ser Tyr Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp 
            100                 105                 110         


Ile Lys 
        


<210>  99
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab32 (INX429)

<400>  99

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  100
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  100

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  101
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab33 (INX430)

<400>  101

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  102
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  102

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  103
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab34 (INX431)

<400>  103

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  104
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  104

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  105
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab35 (INX432)

<400>  105

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  106
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  106

Asn Ile His Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  107
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab36 (INX433)

<400>  107

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  108
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  108

Asn Ile His Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  109
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab37 (INX434)

<400>  109

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Arg His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  110

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  111
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab38 (INX435)

<400>  111

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Phe Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  112
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  112

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  113
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab39 (INX436)

<400>  113

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Lys Trp Ile His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  114
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  114

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  115
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab40 (INX437)

<400>  115

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Met 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  116
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  116

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  117
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab41 (INX438)

<400>  117

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  118
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  118

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  119
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab42 (INX439)

<400>  119

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Ile His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  120
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  120

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  121
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab43 (INX440)

<400>  121

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Trp Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  122

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  123
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab44 (INX441)

<400>  123

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  124

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  125
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab45 (INX442)

<400>  125

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Trp Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  126
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  126

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  127
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab46 (INX443)

<400>  127

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Phe Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  128
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  128

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  129
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab47 (INX444)

<400>  129

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  130
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  130

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  131
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab48 (INX445)

<400>  131

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Met His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  132
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  132

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  133
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab49 (INX446)

<400>  133

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Trp Val His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  134
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  134

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  135
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab50 (INX447)

<400>  135

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  136
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  136

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  137
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab51 (INX448)

<400>  137

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  138
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  138

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  139
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab52 (INX449)

<400>  139

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Ser Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  140
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  140

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  141
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab53 (INX450)

<400>  141

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Phe Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  142
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  142

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  143
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab54 (INX451)

<400>  143

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Ile His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  144
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  144

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  145
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab55 (INX452)

<400>  145

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  146
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  146

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  147
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab56 (INX453)

<400>  147

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Trp Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  148
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  148

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  149
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab57 (INX454)

<400>  149

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Met His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  150

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  151
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab58 (INX455)

<400>  151

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Trp Val His Gly Thr Tyr Phe Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  152
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  152

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  153
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab59 (INX456)

<400>  153

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val His Gly Thr Trp Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  154
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  154

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  155
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab60 (INX457)

<400>  155

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Arg Trp Val Gln Gly Ser Tyr Tyr Ser Pro Gly Tyr Tyr Leu 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  156
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >VL

<400>  156

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Ala Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  157
<400>  157
000              


<210>  158
<400>  158
000     


<210>  159
<400>  159
000     


<210>  160
<400>  160
000               


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab61 (MCT1 3303 A07 or LM-183) - CDR1-HC

<400>  161

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  162
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  162

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  163
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  163

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  164
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  164

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  165
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  165
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  166

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  167

Asp Asn Asp Lys Arg Pro Ser 
1               5           


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  168

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  169
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  169

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  170
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  170
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggtat cagcagaagt cacctggcag tgcccctgtc      120

actgtgatct atgacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aagtccggct ccacagccac attaaccatc actggggttc gagccgagga cgaggctgtc      240

tattactgtg gcagtgcagg caatagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab62 (LM-185 or MCT1 3303 B04-1) - CDR1-HC

<400>  171

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  172
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  172

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  173
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  173

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  174
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  174

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  175
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  175
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  176

Ser Gly Gly Ser Ser Tyr Gly 
1               5           


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  177

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  178

Gly Ser Arg Asp Ser Ser Gly Ala Asp Leu 
1               5                   10  


<210>  179
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  179

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Ser Ser Tyr Gly Trp Phe Gln Gln Lys 
            20                  25                  30          


Ser Pro Gly Ser Ala Leu Val Thr Leu Ile Tyr Tyr Asn Asp Lys Arg 
        35                  40                  45              


Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser Thr 
    50                  55                  60                  


Gly Ile Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu Ala Val Tyr 
65                  70                  75                  80  


Tyr Cys Gly Ser Arg Asp Ser Ser Gly Ala Asp Leu Phe Gly Ala Gly 
                85                  90                  95      


Thr Thr Leu Thr Val Leu 
            100         


<210>  180
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  180
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggca gcagttatgg ctggttccag cagaagtctc ctggcagtgc ccttgtcact      120

ctgatctatt acaacgacaa gagaccctcg aacatccctt cacgattctc cggttccaaa      180

tccggctcca cgggcatttt gaccatctct ggggtccaag ccgaggacga ggctgtctat      240

tactgtggga gcagggacag cagtggtgct gatctatttg gggccgggac aaccctgacc      300

gtcctt                                                                 306


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab63 (LM-186 or MCT1 3308 B04-2) - CDR1-HC

<400>  181

Gly Phe Ser Phe Ser Ser Arg 
1               5           


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  182

Asp Asn Asp Gly Gly Tyr Pro 
1               5           


<210>  183
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  183

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  184
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  184

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  185
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  185
gtcacgaatt cggccgtgac gttggacgag tccgggggcg gcctccagac gcccggagga       60

gggctcagcc tcgtctgcaa ggcctccggg ttctccttca gcagccgggg catgttctgg      120

gtgcgacagg cacctggcaa ggggctggaa tacgttgcgg gtattgataa tgatggtggt      180

tacccaaact acgggtcggc ggtgaagggc cgtgccacca tctcgaggga caacaggcag      240

agcacagtga ggctgcagct gaacaacctc agggctgacg acaccggcac ctactactgc      300

gccaagggtg cttatggtgg tggttggtat gccgctagta gcatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  186

Ser Gly Gly Val Gly Gln Trp Tyr Gly 
1               5                   


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  187

Asp Asn Thr Asn Arg Pro Ser 
1               5           


<210>  188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  188

Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  189
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  189

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Ala Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Gly Gln Trp Tyr Gly Trp Phe Gln 
            20                  25                  30          


Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile His Asp Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  190
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  190
gccctgactc agccgtcctc ggtgtcagca aacccgggag aagccgtcaa gatcacctgc       60

agtggaggtg tcggccagtg gtatggctgg ttccagcaga aggcacctgg cagtgcccct      120

gtcactgtga tccatgacaa caccaacaga ccctcggaca tcccttcacg attctccggt      180

tccaaatccg gctccacggg cacattaacc atcactgggg tccaagccga ggacgaggct      240

gtctatttct gtgcgaatac atacagcgac ggtaatgatg ctccatttgg ggccgggaca      300

accctgaccg tcctt                                                       315


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab64  (LM-188 or MCT1 3308 E08) - CDR1-HC

<400>  191

Gly Phe Thr Phe Ser Ser Arg 
1               5           


<210>  192
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  192

Asp Asn Asp Gly Gly Tyr Pro 
1               5           


<210>  193
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  193

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  194
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  194

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  195
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  195
gtcacgaatt cggccgtgac gttggacgag tccgggggcg gcctccagac gcccggagga       60

gggctcagcc tcgtctgcaa ggcctccggg ttcaccttca gcagccgggg catgttctgg      120

gtgcgacggg cacctggcaa ggggctggaa tacgttgcgg gtattgataa tgatggtggt      180

tacccaaact acgggtcggc ggtgaagggc cgtgccacca tctcgaggga caacaggcag      240

agcacagtga ggctgcagct gaacaacctc agggctgacg acaccggcac ctactactgc      300

gccaagggtg cttatggtgg tggttggtat gccgctagta gcatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  196

Ser Gly Gly Val Gly Gln Trp Tyr Gly 
1               5                   


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  197

Asp Asn Thr Asn Arg Pro Ser 
1               5           


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  198

Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  199
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  199

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Ala Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Gly Gln Trp Tyr Gly Trp Phe Gln 
            20                  25                  30          


Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  200
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  200
gccctgactc agccgtcctc ggtgtcagca aacccgggag aagccgtcaa gatcacctgc       60

agtggaggtg tcggccagtg gtatggctgg ttccagcaga aggcacctgg cagtgcccct      120

gtcactgtga tctatgacaa caccaacaga ccctcggaca tcccttcacg attctccggt      180

tccaaatccg gctccacggg cacattaacc atcactgggg tccaagccga ggacgaggct      240

gtctatttct gtgcgaatac atacagcgac ggtaatgatg ctccatttgg ggccgggaca      300

accctgaccg tcctt                                                       315


<210>  201
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab65 (LM-189 or MCT1 3308 G12) - CDR1-HC

<400>  201

Gly Phe Ser Phe Ser Ser Arg 
1               5           


<210>  202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  202

Asp Asn Asp Gly Gly Tyr Pro 
1               5           


<210>  203
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  203

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  204
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  204

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  205
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  205
gtcacgaatt cggccgtgac gttggacgag tccgggggcg gcctccagac gcccggagga       60

gggctcagcc tcgtctgcaa ggcctccggg ttctccttca gcagccgggg catgttctgg      120

gtgcgacagg cacctggcaa ggggctggaa tacgttgcgg gtattgataa tgatggtggt      180

tacccaaact acgggtcggc ggtgaagggc cgtgccacca tctcgaggga caacaggcag      240

agcacagtga ggctgcagct gaacaacctc agggctgacg acaccggcac ctactactgc      300

gccaagggtg cttatggtgg tggttggtat gccgctagta gcatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  206

Ser Gly Gly Gly Gly Gly Trp Tyr Gly 
1               5                   


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  207

Asp Asn Thr Asn Arg Pro Ser 
1               5           


<210>  208
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  208

Ala Asn Thr Asp Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  209
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  209

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Gly Trp Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Ala Asn Thr Asp Ser Asp Gly Asn Asp Ala Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  210
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  210
gccctgactc agccgtcctc ggtgtcagcg aacccgggag aaaccgtcaa gatcacctgc       60

tccgggggtg gtggcggctg gtatggctgg tatcagcaga agtctcctgg cagtgcccct      120

gtcactgtga tctatgacaa caccaacaga ccctcggaca tcccttcacg attctccggt      180

tccaaatccg gctccacggg cacattaacc atcactgggg tccaagccga ggacgaggct      240

gtctatttct gtgcgaatac agacagcgac ggtaatgatg ctccatttgg ggccgggaca      300

accctgaccg tcctt                                                       315


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab66 (LM-190 or MCT1 3308 H02) - CDR1-HC

<400>  211

Gly Phe Ser Phe Ser Ser Arg 
1               5           


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  212

Asp Asn Asp Gly Gly Tyr Pro 
1               5           


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  213

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  214
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  214

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  215
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  215
tccgccgtga cgttggacga gtccgggggc ggcctccaga cgcccggagg agggctcagc       60

ctcgtctgca aggcctccgg gttctccttc agcagccggg gcatgttctg ggtgcgacag      120

gcacctggca aggggctgga atacgttgcg ggtattgata atgatggtgg ttacccaaac      180

tacgggtcgg cggtgaaggg ccgtgccacc atctcgaggg acaacaggca gagcacagtg      240

aggctgcagc tgaacaacct cagggctgac gacaccggca cctactactg cgccaagggt      300

gcttatggtg gtggttggta tgccgctagt agcatcgacg catggggcca cgggaccgaa      360

gtcatcgtct cctcg                                                       375


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  216

Ser Gly Gly Val Gly Gln Trp Tyr Gly 
1               5                   


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  217

Asp Asn Thr Lys Arg Pro Ser 
1               5           


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  218

Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  219
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  219

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Glu Ala Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Gly Gln Trp Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Thr 
        35                  40                  45              


Lys Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly 
    50                  55                  60                  


Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  220
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  220
gccctgactc agccgtcctc ggtgtcagca aacctgggag aagccgtcaa gatcacctgc       60

agtggaggtg tcggccagtg gtatggctgg taccagcaga aggcacctgg cagtgcccct      120

gtcactgtga tctatgacaa caccaagaga ccctcaaaca tcccttcacg attctccggt      180

tccgcatccg gctccacagc cacactaacc atcactggag tccgagccga ggacgaggct      240

gtctatttct gtgcgaatac atacagcgac ggtaatgatg ctccatttgg ggccgggaca      300

accctgaccg tcctt                                                       315


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab67 (LM-193 or MCT1 3310 A07) - CDR1-HC

<400>  221

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  222
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  222

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  223
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  223

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  224
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  224

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  225
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  225
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  226
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  226

Ser Gly Gly Ser Gly Ser Tyr Gly 
1               5               


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  227

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  228
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  228

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  229
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  229

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Ser Gly Ser Tyr Gly Trp Phe Arg Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  230
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  230
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaacagtcaa gatcacctgc       60

tccgggggta gtggcagcta tggctggttc cggcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacagccac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  231
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab68 (LM-194 or MCT1 3310 B07-1) - CDR1-HC

<400>  231

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  232
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  232

Gly Asp Gly Ala Ser Tyr 
1               5       


<210>  233
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  233

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  234
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  234

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Gly Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  235
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  235
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca gctacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggcatac gtcgctggta tcggcgacgg tgctagttac      180

tcagcatacg gggtggcggt gaagggccga gccaccatct cgagggacaa cgggcagagc      240

acagtgaggc tgcagctgaa caacctcagg gctgaggaca ccggcaccta ctactgcgcc      300

aaagcttccg agggttccta ctggtattat gaaactggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  236
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  236

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  237

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  238
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  238

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  239
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  239

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  240
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  240
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacagccac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab69 (LM-195 or MCT1 3310 B07-2) - CDR1-HC

<400>  241

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  242
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  242

Gly Asp Gly Ala Ser Tyr 
1               5       


<210>  243
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  243

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  244
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  244

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Gly Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  245
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  245
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca gctacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggcatac gtcgctggta tcggcgacgg tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcgcc      300

aaagcttccg agggttccta ctggtattat gaaactggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  246
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  246

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  247
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  247

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  248
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  248

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  249
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  249

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  250
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  250
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacagccac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  251
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab70 (LM-197 or MCT1 3310 E01) - CDR1-HC

<400>  251

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  252
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  252

Gly Asn Ser Ala Ser Tyr 
1               5       


<210>  253
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  253

Pro Ser Asp Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  254
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  254

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Asn Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Lys Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ser Asp Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  255
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  255
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca gctacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaattc gtcgctggta ttggcaacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acagtgaggc tgaagctgaa caacctcagg gctgaggaca ccggcaccta ctactgcgcc      300

aaaccttccg atggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  256
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  256

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  257
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  257

Asp Asn Asp Lys Arg Pro Ser 
1               5           


<210>  258
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  258

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  259
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  259

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  260
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  260
gccctgactc agccgtcctc ggtgtcagca aacccgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggtat cagcagaagt cacctggcag tgcccctgtc      120

actgtgatct atgacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aagtccggct ccacagccac attaaccatc actggggttc gagccgagga cgaggctgtc      240

tattactgtg gcagtgcagg caatagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  261
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab71 (LM-198 or MCT1 3310 E03) - CDR1-HC

<400>  261

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  262
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  262

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  263
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  263

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  264
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  264

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Ala Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  265
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  265
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

gcactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  266
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  266

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  267
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  267

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  268
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  268

Gly Ser Gly Asp Ser Ser Gly Gly Ile 
1               5                   


<210>  269
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  269

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Val Asp Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Gly Asp Ser Ser Gly Gly Ile Phe Gly Ala Gly 
                85                  90                  95      


Thr Thr Leu Thr Val Leu 
            100         


<210>  270
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  270
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggctcc      180

aaatccggct ccacggccac attaaccatc actggggtcc aagtcgacga cgaggctgtc      240

tatttctgtg ggagtggaga cagcagtggt ggtatatttg gggccgggac aaccctgacc      300

gtcctt                                                                 306


<210>  271
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab72 (LM-199 or MCT1 3310 E04) - CDR1-HC

<400>  271

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  272
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  272

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  273
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  273

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  274
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  274

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Arg Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  275
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  275
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccggacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  276
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  276

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  277
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  277

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  278
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  278

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  279
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  279

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  280
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  280
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcagacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  281
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab73 (LM-201 or MCT1 3310 H09) - CDR1-HC

<400>  281

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  282
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  282

Gly Asp Gly Ala Ser Tyr 
1               5       


<210>  283
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  283

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  284
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  284

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Gly Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  285
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  285
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca gctacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggcatac gtcgctggta tcggcgacgg tgctagttac      180

tcagcatacg gggtggcggt gaagggccga gccaccatct cgagggacaa cgggcagagc      240

acagtgaggc tgcagctgaa caacctcagg gctgaggaca ccggcaccta ctactgcgcc      300

aaagcttccg agggttccta ctggtattat gaaactggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  286
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  286

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  287
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  287

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  288
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  288

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  289
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  289

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  290
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  290
gccctgactc agccgtcctc ggtgtcagca aacctaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacagccac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  291
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab74 (LM-202 or MCT1 3310 H12) - CDR1-HC

<400>  291

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  292
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  292

Gly Asp Gly Ala Ser Tyr 
1               5       


<210>  293
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  293

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  294
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  294

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Gly Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  295
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  295
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca gctacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggcatac gtcgctggta tcggcgacgg tgctagttac      180

tcagcatacg gggtggcggt gaagggccga gccaccatct cgagggacaa cgggcagagc      240

acagtgaggc tgcagctgaa caacctcagg gctgaggaca ccggcaccta ctactgcgcc      300

aaagcttccg agggttccta ctggtattat gaaactggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  296
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  296

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  297
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  297

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  298
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  298

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  299
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  299

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  300
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  300
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacagccac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  301
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab75  (LM-203 or MCT1 3311 A07) - CDR1-HC

<400>  301

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  302
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  302

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  303
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  303

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  304
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  304

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  305
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  305
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  306
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  306

Ser Gly Gly Ser Gly Ser Tyr Gly 
1               5               


<210>  307
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  307

Ala Asn Thr Asn Arg Pro Ser 
1               5           


<210>  308
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  308

Gly Ser Ala Asp Ser Thr Gly Ala Gly Met 
1               5                   10  


<210>  309
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  309

Ala Leu Thr Gln Pro Ser Ser Val Ser Leu Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Ser Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Ala Asn Thr Asn 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Ile 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Ala Asp Ser Thr Gly Ala Gly Met Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  310
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  310
gccctgactc agccgtcctc ggtgtcacta aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggta gtggcagcta cggctggttc cagcagaagt cacctggcag tgcccctgtc      120

actctgatct atgctaatac caacagaccc tcagacatcc cttcacgatt ctccggttcc      180

aaatctggct ccacaaacac attaaccatc actggggtcc aagccgagga cgaggctatc      240

tattactgtg ggagtgcaga cagcactggt gctggtatgt ttggggccgg gacaaccctg      300

accgtcctt                                                              309


<210>  311
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab76 (LM-204 or MCT1 3311 B11) - CDR1-HC

<400>  311

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  312
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  312

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  313
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  313

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  314
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  314

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  315
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  315
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  316
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  316

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  317
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  317

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  318
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  318

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  319
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  319

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  320
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  320
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  321
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab77 (LM-205 or MCT1 3311 C05) - CDR1-HC

<400>  321

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  322
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  322

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  323
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  323

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  324
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  324

Ala Cys Gly Ala Ala Thr Thr Cys Gly Gly Cys Cys Gly Thr Gly Ala 
1               5                   10                  15      


Cys Gly Thr Thr Gly Gly Ala Cys Gly Ala Gly Thr Cys Cys Gly Gly 
            20                  25                  30          


Gly Gly Gly Cys Gly Gly Cys Cys Thr Cys Cys Gly Gly Ala Cys Gly 
        35                  40                  45              


Cys Cys Cys Gly Gly Ala Gly Gly Ala Ala Cys Gly Cys Thr Cys Ala 
    50                  55                  60                  


Gly Cys Cys Thr Cys Gly Thr Cys Thr Gly Cys Ala Ala Gly Gly Cys 
65                  70                  75                  80  


Cys Thr Cys Cys Gly Gly Gly Thr Thr Cys Gly Ala Cys Thr Thr Cys 
                85                  90                  95      


Ala Gly Cys Ala Ala Cys Thr Ala Cys Gly Ala Ala Ala Thr Gly Cys 
            100                 105                 110         


Thr Cys Thr Gly Gly Gly Thr Gly Cys Gly Ala Cys Ala Gly Gly Cys 
        115                 120                 125             


Gly Cys Cys Cys Gly Gly Cys Ala Ala Gly Gly Gly Gly Cys Thr Gly 
    130                 135                 140                 


Gly Ala Ala Thr Ala Cys Gly Thr Cys Gly Cys Thr Gly Gly Thr Ala 
145                 150                 155                 160 


Thr Thr Gly Gly Cys Gly Ala Cys Ala Gly Thr Gly Cys Thr Ala Gly 
                165                 170                 175     


Thr Thr Ala Cys Thr Cys Ala Gly Cys Ala Thr Ala Cys Gly Gly Gly 
            180                 185                 190         


Gly Thr Gly Gly Cys Gly Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys 
        195                 200                 205             


Gly Thr Gly Cys Cys Ala Cys Cys Ala Thr Cys Thr Cys Gly Ala Gly 
    210                 215                 220                 


Gly Gly Ala Cys Ala Ala Cys Gly Gly Gly Cys Ala Gly Ala Gly Cys 
225                 230                 235                 240 


Ala Cys Ala Cys Thr Gly Ala Gly Gly Cys Thr Gly Cys Ala Gly Cys 
                245                 250                 255     


Thr Gly Ala Ala Cys Gly Gly Cys Cys Thr Cys Ala Gly Gly Gly Cys 
            260                 265                 270         


Thr Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Gly Cys Ala Cys Cys 
        275                 280                 285             


Thr Ala Cys Thr Ala Cys Thr Gly Cys Ala Cys Cys Ala Ala Ala Gly 
    290                 295                 300                 


Cys Thr Thr Cys Cys Gly Ala Gly Gly Gly Thr Thr Cys Cys Thr Ala 
305                 310                 315                 320 


Cys Thr Gly Gly Thr Ala Thr Thr Ala Thr Gly Ala Ala Gly Cys Thr 
                325                 330                 335     


Gly Gly Thr Gly Gly Thr Ala Thr Cys Gly Ala Cys Ala Cys Ala Thr 
            340                 345                 350         


Gly Gly Gly Gly Cys Cys Ala Cys Gly Gly Gly Ala Cys Cys Gly Ala 
        355                 360                 365             


Ala Gly Thr Cys Ala Thr Cys Gly Thr Cys Thr Cys Cys Thr Cys Gly 
    370                 375                 380                 


<210>  325
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  325
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccggacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  326
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  326

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  327
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  327

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  328
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  328

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  329
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  329

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  330
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  330
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcagacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  331
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab78 (LM-206 or MCT1 3311 F10) - CDR1-HC

<400>  331

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  332
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  332

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  333
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  333

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  334
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  334

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  335
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  335
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggagcg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  336
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  336

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  337
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  337

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  338
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  338

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  339
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  339

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  340
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  340
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  341
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab79 (LM-207 or MCT1 3311 G09) - CDR1-HC

<400>  341

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  342
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  342

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  343
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  343

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  344
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  344

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  345
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  345
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  346
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  346

Ser Gly Gly Gly Gly Ser Tyr Gly 
1               5               


<210>  347
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  347

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  348
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  348

Gly Ser Ala Gly Asn Ser Gly Ala 
1               5               


<210>  349
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  349

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ala Gly Asn Ser Gly Ala Phe Gly Ala Gly Thr 
                85                  90                  95      


Thr Leu Thr Val Leu 
            100     


<210>  350
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  350
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcagcta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc gagccgagga cgaggctgtc      240

tatttctgtg ggagtgcagg caacagtggt gcatttgggg ccgggacaac cctgaccgtc      300

ctt                                                                    303


<210>  351
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab80 (LM-208 or MCT1 3312 H10) - CDR1-HC

<400>  351

Gly Phe Ser Phe Ser Ser Arg 
1               5           


<210>  352
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  352

Asp Asn Asp Gly Gly Tyr 
1               5       


<210>  353
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  353

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  354
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  354

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  355
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  355
gtcacgaatt cggccgtgac gttggacgag tccgggggcg gcctccagac gcccggagga       60

gggctcagcc tcgtctgcaa ggcctccggg ttctccttca gcagccgggg catgttctgg      120

gtgcgacagg cacctggcaa ggggctggaa tacgttgcgg gtattgataa tgatggtggt      180

tacccaaact acgggtcggc ggtgaagggc cgtgccacca tctcgaggga caacaggcag      240

agcacagtga ggctgcagct gaacaacctc agggctgacg acaccggcac ctactactgc      300

gccaagggtg cttatggtgg tggttggtat gccgctagta gcatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  356
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  356

Ser Gly Gly Gly Ser Ser Ser Tyr Tyr Gly 
1               5                   10  


<210>  357
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  357

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  358
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  358

Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  359
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  359

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Lys Ser Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Ser Ser Ser Tyr Tyr Gly Trp Tyr 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn 
        35                  40                  45              


Asn Lys Arg Pro Ser Asn Ile Pro Ser Gln Phe Ser Gly Ser Lys Ser 
    50                  55                  60                  


Gly Ser Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105     


<210>  360
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  360
gccctgactc agccgtcctc ggtgtcagca aagtcaggag aaaccgtcaa gatcacctgc       60

tccgggggtg gtagcagcag ctactatggc tggtatcagc agaagtcacc tggcagtgcc      120

cctgtcactg tgatctatga caacaacaag agaccctcga acatcccttc acaattctcc      180

ggttccaaat ctggctccac aagcacatta accatcactg gggtccaagc cgacgacgag      240

gctgtctatt tctgtgcgaa tacatacagc gacggtaatg atgctccatt tggggccggg      300

acaaccctga ccgtcctt                                                    318


<210>  361
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab81 (LM-209 or MCT1 3313 A11) - CDR1-HC

<400>  361

Gly Phe Ser Phe Ser Ser Arg 
1               5           


<210>  362
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  362

Asp Asn Asp Gly Gly Tyr 
1               5       


<210>  363
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  363

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  364
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  364

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Ile Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  365
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  365
gtcacgaatt cggccgtgac gttggacgag tccgggggcg gcctccagac gcccggagga       60

gctctcagcc tcatctgcaa ggcctccggg ttctccttca gcagccgggg catgttctgg      120

gtgcgacagg cacctggcaa ggggctggaa tacgttgcgg gtattgataa tgatggtggt      180

tacccaaact acgggtcggc ggtgaagggc cgtgccacca tctcgaggga caacaggcag      240

agcacagtga ggctgcagct gaacaacctc agggctgacg acaccggcac ctactactgc      300

gccaagggtg cttatggtgg tggttggtat gccgctagta gcatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  366

Ser Gly Gly Val Gly Gln Trp Tyr Gly 
1               5                   


<210>  367
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  367

Asp Asn Thr Asn Arg Pro Ser 
1               5           


<210>  368
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  368

Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  369
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  369

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Ala Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Gly Gln Trp Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  370
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  370
gccctgactc agccgtcctc ggtgtcagca aacccgggag aagccgtcaa gatcacctgc       60

agtggaggtg tcggccagtg gtatggctgg taccagcaga aggcacctgg cagtgcccct      120

gtcactgtga tctatgacaa caccaacaga ccctcggaca tcccttcacg attctccggt      180

tccaaatccg gctccacaaa cacattaacc atcactgggg tccaagccga ggacgaggct      240

gtctatttct gtgcgaatac atacagcgac ggtaatgatg ctccatttgg ggccgggaca      300

accctgaccg tcctt                                                       315


<210>  371
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab82 (LM-210 or MCT1 3313 B10) - CDR1-HC

<400>  371

Gly Phe Ser Phe Ser Ser Arg 
1               5           


<210>  372
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  372

Asp Asn Asp Gly Gly Tyr 
1               5       


<210>  373
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  373

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  374
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  374

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  375
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  375
gtcacgaatt cggccgtgac gttggacgag tccgggggcg gcctccagac gcccggagga       60

gggctcagcc tcgtctgcaa ggcctccggg ttctccttca gcagccgggg catgttctgg      120

gtgcgacagg cacctggcaa ggggctggaa tacgttgcgg gtattgataa tgatggtggt      180

tacccaaact acgggtcggc ggtgaagggc cgtgccacca tctcgaggga caacaggcag      240

agcacagtga ggctgcagct gaataacctc agggctgacg acaccggcac ctactactgc      300

gccaagggtg cttatggtgg tggttggtat gccgctagta gcatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  376
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  376

Ser Gly Gly Val Gly Gln Trp Tyr Gly 
1               5                   


<210>  377
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  377

Asp Asn Ala Asn Arg Pro Ser 
1               5           


<210>  378
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  378

Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  379
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  379

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Ala Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Gly Gln Trp Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Ala 
        35                  40                  45              


Asn Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  380
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  380
gccctgactc agccgtcctc ggtgtcagca aacccgggag aagccgtcaa gatcacctgc       60

agtggaggtg tcggccagtg gtatggctgg taccagcaga aggcacctgg cagtgcccct      120

gtcactgtga tctatgacaa cgccaacaga ccctcggaca tcccttcacg attctccggt      180

tccaaatccg gctccacggg cacattaacc atcactgggg tccaagccga ggacgaggct      240

gtctatttct gtgcgaatac atacagcgac ggtaatgatg ctccatttgg ggccgggaca      300

accctgaccg tcctt                                                       315


<210>  381
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab83 (LM-211 or MCT1 3309 B01) - CDR1-HC

<400>  381

Gly Phe Ser Phe Ser Ser Arg 
1               5           


<210>  382
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  382

Asp Asn Asp Gly Gly Tyr 
1               5       


<210>  383
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  383

Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp Ala 
1               5                   10                  15  


<210>  384
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  384

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Ile Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Arg 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Asp Asn Asp Gly Gly Tyr Pro Asn Tyr Gly Ser Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Arg Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Tyr Gly Gly Gly Trp Tyr Ala Ala Ser Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  385
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  385
gtcacgaatt cggccgtgac gttggacgag tccgggggcg gcctccagac gcccggagga       60

gctctcagcc tcatctgcaa ggcctccggg ttctccttca gcagccgggg catgttctgg      120

gtgcgacagg cacctggcaa ggggctggaa tacgttgcgg gtattgataa tgatggtggt      180

tacccaaact acgggtcggc ggtgaagggc cgtgccacca tctcgaggga caacaggcag      240

agcacagtga ggctgcagct gaacaacctc agggctgacg acaccggcac ctactactgc      300

gccaagggtg cttatggtgg tggttggtat gccgctagta gcatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  386
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  386

Ser Gly Gly Val Gly Gln Trp Tyr Gly 
1               5                   


<210>  387
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  387

Asp Asn Thr Asn Arg Pro Ser 
1               5           


<210>  388
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  388

Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro 
1               5                   10      


<210>  389
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  389

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Ala Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Val Gly Gln Trp Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Asp Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Ala Asn Thr Tyr Ser Asp Gly Asn Asp Ala Pro Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  390
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  390
gccctgactc agccgtcctc ggtgtcagca aacccgggag aagccgtcaa gatcacctgc       60

agtggaggtg tcggccagtg gtatggctgg taccagcaga aggcacctgg cagtgcccct      120

gtcactgtga tctatgacaa caccaacaga ccctcggaca tcccttcacg attctccggt      180

tccaaatccg gctccacaaa cacattaacc atcactgggg tccaagccga ggacgaggct      240

gtctatttct gtgcgaatac atacagcgac ggtaatgatg ctccatttgg ggccgggaca      300

accctgaccg tcctt                                                       315


<210>  391
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab84 (LM-184 or MCT1  3303 C03) - CDR1-HC

<400>  391

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  392
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  392

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  393
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  393

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  394
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  394

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  395
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  395
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  396
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  396

Ser Gly Gly Thr Tyr Ser Tyr Gly 
1               5               


<210>  397
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  397

Gln Asn Asp Lys Arg Pro Ser 
1               5           


<210>  398
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  398

Gly Ser Gly Asp Thr Thr Gly Gly Ile 
1               5                   


<210>  399
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  399

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Thr Tyr Ser Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Gln Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Gly Asp Thr Thr Gly Gly Ile Phe Gly Ala Gly 
                85                  90                  95      


Thr Thr Leu Thr Val Leu 
            100         


<210>  400
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  400
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tctgggggca cctatagtta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct atcaaaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc aagccgagga cgaggctgtc      240

tatttctgtg ggagtggaga caccaccggt ggtatatttg gggccgggac aaccctgacc      300

gtcctt                                                                 306


<210>  401
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab85 (LM-187 or MCT1 3308 B07) - CDR1-HC

<400>  401

Gly Phe Gly Phe Thr Asn Tyr 
1               5           


<210>  402
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  402

Ser Ser Gly Gly Ala Tyr 
1               5       


<210>  403
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  403

Ala Pro Cys Gly Ser Trp Cys Gly Trp Gly Tyr Thr Gly Val Asp Asn 
1               5                   10                  15      


Ile Asp Ala 
            


<210>  404
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  404

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Leu Val Ser Leu Val Cys Lys Ala Ser Gly Phe Gly Phe Thr Asn Tyr 
            20                  25                  30          


Glu Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Val Ser Ser Gly Gly Ala Tyr Ala Asp Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Val Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ala Pro Cys Gly Ser Trp Cys Gly Trp Gly Tyr Thr Gly Val 
            100                 105                 110         


Asp Asn Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125             


<210>  405
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  405
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggact ggtcagtctc       60

gtctgcaagg cctccgggtt cggcttcacc aattatgaga tccactgggt gcgacaggcg      120

cccggcaagg ggctggagtg ggtcggtttt gttagtagtg gtggtgctta cgcagattac      180

gcgccggcgg tgaagggccg tgccaccatc acgagggaca acgggcagag cacagtgagg      240

ctgcagctgg tcaacctcag ggcggaggac accggcacct actactgcac cagagctcct      300

tgtggtagtt ggtgtggttg gggttatact ggtgtcgata acatcgacgc gtggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  406
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  406

Ser Gly Gly Gly Arg Gly Ser His Tyr Gly 
1               5                   10  


<210>  407
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  407

Ala Asn Asn Gln Arg Pro Ser 
1               5           


<210>  408
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  408

Gly Gly Tyr Asp Ser Gly Ala Thr 
1               5               


<210>  409
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  409

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Gly Ile Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Arg Gly Ser His Tyr Gly Trp Tyr 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Ala Asn 
        35                  40                  45              


Asn Gln Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Gly Tyr Asp Ser Gly Ala Thr Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  410
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  410
gccctgactc agccgtcctc ggtgtcagcg aacccaggag gaatcgtcaa gatcacctgc       60

tccgggggtg gtcgcggcag ccactatggc tggtatcagc agaagtctcc tggcagtgcc      120

cctgtcactc tgatctatgc taacaaccag agaccctcgg acatcccttc gcgattctcc      180

ggttccgaat ccggctccac ggccacatta accatcactg gggtccaagc cgaggacgag      240

gctgtctatt tctgtggtgg ctacgacagc ggtgctacat ttggggccgg gacaaccctg      300

accgtcctt                                                              309


<210>  411
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab86 (LM-191 or MCT1 3310 A01) - CDR1-HC

<400>  411

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  412
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  412

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  413
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  413

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  414
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  414

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  415
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  415
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  416
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  416

Ser Gly Ser Ser Gly Ser Tyr Gly 
1               5               


<210>  417
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  417

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  418
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  418

Gly Ser Tyr Gly Ser Thr Asp Ala Ala Ile 
1               5                   10  


<210>  419
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  419

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Ser Pro Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Ser Ser Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Tyr Gly Ser Thr Asp Ala Ala Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  420
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  420
gccctgactc agccgtcctc ggtgtccgcg agcccaggag gaaccgtcaa gatcacctgc       60

tccgggagta gtggcagcta tggctggtat cagcagaagt cacctggcag tgcccctgtc      120

actgtgatct attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc aagccgagga cgaggctgtc      240

tatttctgtg ggagctacgg cagcactgat gctgctatat ttggggccgg gacaaccctg      300

accgtcctt                                                              309


<210>  421
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab87 (LM-192 or MCT1 3310 A02-1) - CDR1-HC

<400>  421

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  422
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  422

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  423
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  423

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  424
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  424

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  425
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  425
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  426
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  426

Ser Gly Gly Tyr Ser Ser Tyr Gly 
1               5               


<210>  427
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  427

Tyr Asn Ala Lys Arg Pro Ser 
1               5           


<210>  428
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  428

Gly Thr Ala Asp Arg Ser Ser Thr Ala Leu 
1               5                   10  


<210>  429
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  429

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Tyr Ser Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Tyr Asn Ala Lys 
        35                  40                  45              


Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Thr Ala Asp Arg Ser Ser Thr Ala Leu Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  430
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  430
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtt acagcagcta tggctggtat cagcagaagt ctcctggcag tgctcctgtc      120

actctgatct attacaacgc caagagaccc tcgaacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacagccac attaaccatc actggggtcc aagccgagga cgaggctgtc      240

tatttctgtg ggactgcaga caggagcagt actgctttat ttggggccgg gacaaccctg      300

accgtcctt                                                              309


<210>  431
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab88 (LM-196 or MCT1 3310 C01) - CDR1-HC

<400>  431

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  432
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  432

Gly Asp Gly Ala Ser Tyr 
1               5       


<210>  433
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  433

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  434
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  434

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Gly Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Thr Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  435
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  435
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca gctacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggcatac gtcgctggta tcggcgacgg tgctagttac      180

tcagcatacg gggtggcggt gaagggccga gccaccatct cgagggacaa cgggcagagc      240

acagtgaggc tgcagctgaa caacctcagg gctgaggaca ccggcaccta ctactgcgcc      300

aaagcttccg agggttccta ctggtattat gaaactggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  436
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  436

Ser Gly Gly Ser Gly Ser Tyr Gly 
1               5               


<210>  437
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  437

Tyr Asn Asp Lys Arg Pro Ser 
1               5           


<210>  438
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  438

Gly Ser Gly Asp Arg Ser Tyr Asp Gly Met 
1               5                   10  


<210>  439
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  439

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Ser Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile His Tyr Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Gly Asp Arg Ser Tyr Asp Gly Met Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  440
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  440
gccctgactc agccgtcctc ggtgtcagca aacccgggag aaaccgtcga gatcacctgc       60

tccgggggta gtggcagcta cggctggtac cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatcc attacaacga caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

gcatccggct ccacagccac attaaccatc actggggtcc aagtcgagga cgaggctgtc      240

tatttctgtg ggagtggaga caggagttat gatggtatgt tcggggccgg gacaaccctg      300

accgtcctt                                                              309


<210>  441
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab89 (LM-200 or MCT1 3310 F12) - CDR1-HC

<400>  441

Gly Phe Asp Phe Ser Asn Tyr 
1               5           


<210>  442
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  442

Gly Asp Ser Ala Ser Tyr 
1               5       


<210>  443
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  443

Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile Asp Thr 
1               5                   10                  15      


<210>  444
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  444

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gly Ile Gly Asp Ser Ala Ser Tyr Ser Ala Tyr Gly Val Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Gly Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Ser Glu Gly Ser Tyr Trp Tyr Tyr Glu Ala Gly Gly Ile 
            100                 105                 110         


Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  445
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  445
acgaattcgg ccgtgacgtt ggacgagtcc gggggcggcc tccagacgcc cggaggaacg       60

ctcagcctcg tctgcaaggc ctccgggttc gacttcagca actacgaaat gctctgggtg      120

cgacaggcgc ccggcaaggg gctggaatac gtcgctggta ttggcgacag tgctagttac      180

tcagcatacg gggtggcggt gaagggccgt gccaccatct cgagggacaa cgggcagagc      240

acactgaggc tgcagctgaa cggcctcagg gctgaggaca ccggcaccta ctactgcacc      300

aaagcttccg agggttccta ctggtattat gaagctggtg gtatcgacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  446
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  446

Ser Gly Gly Ser Ser Thr Tyr Gly 
1               5               


<210>  447
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  447

Arg Asn Asp Asn Arg Pro Ser 
1               5           


<210>  448
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  448

Gly Ser Ala Asp Ser Ser Gly Ala Ile 
1               5                   


<210>  449
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  449

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Ser Ser Thr Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Arg Asn Asp Asn 
        35                  40                  45              


Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Lys Tyr Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Leu Cys Gly Ser Ala Asp Ser Ser Gly Ala Ile Phe Gly Ala Gly 
                85                  90                  95      


Thr Thr Leu Thr Val Leu 
            100         


<210>  450
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  450
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcga gatcacctgc       60

tccgggggta gcagcaccta tggctggtac cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct ataggaacga caacagaccc tcaaacatcc cttcacgatt ctccggttcc      180

aaatacggct ccacgggcac attaaccatc actggggtcc aagccgagga cgaggctgtc      240

tatttatgtg ggagtgcaga cagcagtggt gctatatttg gggccgggac aaccctgacc      300

gtcctt                                                                 306


<210>  451
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab90 (MCT1 3308 A05) - CDR1-HC

<400>  451

Gly Phe Ser Phe Ser Gly Phe 
1               5           


<210>  452
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  452

Asp Asp Gly Gly Ser Ser 
1               5       


<210>  453
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  453

Asp Thr Ala Ala Cys Thr Tyr Pro Cys Gly Ser Tyr Val His Thr Ile 
1               5                   10                  15      


Asp Thr 
        


<210>  454
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  454

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Gly Phe 
            20                  25                  30          


Ser Met Gly Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Asp Gly Gly Ser Ser Thr Tyr Tyr Gly Ala Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Ser Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Ala Ala Cys Thr Tyr Pro Cys Gly Ser Tyr Val His 
            100                 105                 110         


Thr Ile Asp Thr Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125         


<210>  455
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  455
tcggccgtga cgttggacga gtccgggggc ggcctccaga cgcccggagg agcgctcagt       60

ctcgtctgca aggcctccgg gttctccttc agtggtttca gcatgggttg ggtgcgccag      120

acgcccggca aagggctgga atgggtcgct ggtattgatg atggtggcag tagcacctac      180

tacggggcgg cggtgaaggg ccgtgccacc atctcgaggg acaacgggca gagcacagtg      240

aggctgcagc tgagcaacct cagggctgag gacaccggca tctactactg cgccagagat      300

actgctgctt gtacttatcc ttgtggttct tatgtgcata cgatagacac atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  456
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  456

Ser Gly Gly Gly Gly Asp Tyr Gly 
1               5               


<210>  457
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  457

Tyr Ser Asp Lys Arg Pro Pro 
1               5           


<210>  458
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  458

Gly Gly Trp Asp Asp Thr Asn Gly Gly Ile 
1               5                   10  


<210>  459
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  459

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Asp Tyr Gly Trp Phe Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Tyr Ser Asp Lys 
        35                  40                  45              


Arg Pro Pro Asn Ile Pro Ser Arg Phe Ser Gly Ser Leu Ser Gly Ser 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Gly Trp Asp Asp Thr Asn Gly Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  460
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  460
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc       60

tccgggggtg gtggcgacta tggctggttc cagcagaagt ctcctggcag tgcccctgtc      120

actgtgatct attacagcga caagagaccc ccgaacatcc cttcacgatt ctccggttcc      180

ctatccggct ccacagccac attaaccatc actggggtcc aagccgagga cgaggctgtc      240

tattactgtg gtggctggga cgatactaat ggtggtatat ttggggccgg gacaaccctg      300

accgtcctt                                                              309


<210>  461
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab91 (MCT1 3309 D07) - CDR1-HC

<400>  461

Gly Phe Ser Phe Ser Ser Tyr 
1               5           


<210>  462
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  462

Arg Ser Ser Gly Ser Ser 
1               5       


<210>  463
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  463

Ala Gly Cys Ser Asp Cys Trp Arg Ser Thr Pro Gly Arg Ile Asp Ala 
1               5                   10                  15      


<210>  464
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  464

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Arg Ser Ser Gly Ser Ser Thr Tyr Tyr Gly Ala Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Gly Cys Ser Asp Cys Trp Arg Ser Thr Pro Gly Arg Ile 
            100                 105                 110         


Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  465
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  465
acgaattcgg ccgtgacgtt ggacgagtct gggggcggcc tccagacgcc cggaggaggg       60

ctcagcctcg tctgcaaggc ctccgggttc tccttcagca gttatggcat gggctgggtg      120

cgacaggcgc ccggcaaggg gctggaattc atcgcgggta ttagaagcag tggtagtagc      180

acatactacg gggcggcggt gaagggccgt gccaccatca cgagggacaa cgggcagagc      240

acagtgaggc tgcagctgaa caacctcagg gctgaggaca ccgccaccta ctactgcgcc      300

aaagctggtt gtagtgattg ttggcgtagt actcctggta ggatcgacgc atggggccac      360

gggaccgaag tcatcgtctc ctcg                                             384


<210>  466
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  466

Ser Gly Ser Ser Ser Gly Tyr Gly Tyr Gly 
1               5                   10  


<210>  467
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  467

Thr Asn Thr Asn Arg Pro Ser 
1               5           


<210>  468
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  468

Gly Ser Tyr Asp Ser Asn Thr Tyr Leu Gly Leu 
1               5                   10      


<210>  469
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  469

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Ser Ser Ser Gly Tyr Gly Tyr Gly Trp Tyr 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Thr Asn 
        35                  40                  45              


Thr Asn Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser 
    50                  55                  60                  


Gly Ser Thr Asn Thr Leu Thr Ile Ala Gly Val Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Gly Ser Tyr Asp Ser Asn Thr Tyr Leu Gly Leu 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105     


<210>  470
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  470
gccctgactc agccgtcctc ggtgtcagca aacctgggag gaaccgtcga gatcacctgc       60

tccgggagta gcagtggcta tggttatggc tggtatcagc agaagtcacc tggcagtgcc      120

cctgtcactc tgatctatac taacaccaac agaccctcgg acatcccttc gcgattctcc      180

ggttccacat ccggctccac aaacacatta acgatcgctg gggtccaagc cgaggacgag      240

gctgtctatt attgtgggag ctacgacagc aacacttatc ttggtctatt tggggccggg      300

acaaccctga ccgtcctt                                                    318


<210>  471
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab92 (MCT1 3310 A05) - CDR1-HC

<400>  471

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  472
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  472

Ser Lys Asp Gly Gly Ser Asp 
1               5           


<210>  473
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  473

Gly Ile Gly Val Gly Asn Ile Asp Ala 
1               5                   


<210>  474
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  474

Ala Val Thr Leu Asp Glu Ser Glu Gly Gly Leu His Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Asp Gly Gly Ser Asp Thr Ala Tyr Glu Thr Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asp Gly Gln Ser Thr Val 
65                  70                  75                  80  


Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ile Gly Val Gly Asn Ile Asp Ala Trp Gly His Gly 
            100                 105                 110         


Thr Glu Val Ile Val Ser Ser 
        115                 


<210>  475
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  475
gccgtgacgt tggacgagtc cgagggcggc ctccatacac ccggaggagg gctcagcctc       60

gtctgcaagg cctccgggtt caccttcagc agttatgcca tgtactggat ccgacaggcg      120

cccggcaagg ggctggagtg ggtcgcctat attagcaagg atggtggtag tgacacagca      180

tacgagacag cggtgaaggg ccgtgccacc atctcgaggg acgacgggca gagcacagtg      240

aggctgcagc tgaacaacct cagggctgag gacaccgcca cctactactg cgccagaggt      300

attggtgttg gtaacatcga cgcatggggc cacgggaccg aagtcatcgt ctcctcc         357


<210>  476
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  476

Ser Gly Ser Ser Ser Gly Tyr Gly Tyr Gly 
1               5                   10  


<210>  477
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  477

Thr Asn Thr Asn Arg Pro Ser 
1               5           


<210>  478
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  478

Gly Ser Tyr Asp Ser Asn Thr Tyr Leu Gly Leu 
1               5                   10      


<210>  479
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  479

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Thr Ser Asp Asn Asn Tyr Phe Gly Trp Tyr 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Gly Asn 
        35                  40                  45              


Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser 
    50                  55                  60                  


Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Ser Tyr Asp Thr Tyr Val Asn Asp Asp Ile 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105     


<210>  480
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  480
gccctgactc agccgtcctc ggtgtcagca aacctgggag aaaccgtcaa gatcacctgc       60

tccgggacta gtgacaataa ctactttggt tggtatcagc agaagtctcc tggcagtgcc      120

cctgtcacgg tgatctatgg caacgacaag agaccctcgg acatcccttc acgattctcc      180

ggttccaaat ccggctccac ggccacatta accatcactg gggtccaagc cgacgacgag      240

gctgtctatt tctgtgggag ctatgacacc tatgttaatg atgatatatt tggggccggg      300

acaaccctga ccgtccta                                                    318


<210>  481
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab93 (MCT1 3310 A12) - CDR1-HC

<400>  481

Gly Phe Asp Phe Ser Ser Tyr 
1               5           


<210>  482
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  482

Tyr Lys Asp Gly Gly Ser Asp 
1               5           


<210>  483
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  483

Gly Ile Gly Ile Gly Asn Ile Asp Ala 
1               5                   


<210>  484
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  484

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Tyr Lys Asp Gly Gly Ser Asp Thr Ala Tyr Glu Thr Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asp Gly Gln Ser Thr Met 
65                  70                  75                  80  


Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ile Gly Ile Gly Asn Ile Asp Ala Trp Gly His Gly 
            100                 105                 110         


Thr Glu Val Ile Val Ser Ser 
        115                 


<210>  485
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  485

Gly Cys Cys Gly Thr Gly Ala Cys Gly Thr Thr Gly Gly Ala Cys Gly 
1               5                   10                  15      


Ala Gly Thr Cys Cys Gly Gly Gly Gly Gly Cys Gly Gly Cys Cys Thr 
            20                  25                  30          


Cys Cys Ala Gly Ala Cys Gly Cys Cys Cys Gly Gly Ala Gly Gly Ala 
        35                  40                  45              


Gly Gly Gly Cys Thr Cys Ala Gly Cys Cys Thr Cys Gly Thr Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Cys Thr Cys Cys Gly Gly Gly Thr Thr 
65                  70                  75                  80  


Thr Gly Ala Cys Thr Thr Cys Ala Gly Cys Ala Gly Thr Thr Ala Cys 
                85                  90                  95      


Gly Cys Cys Ala Thr Gly Thr Ala Cys Thr Gly Gly Ala Thr Cys Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Gly Cys Cys Cys Gly Gly Cys Ala Ala 
        115                 120                 125             


Gly Gly Gly Gly Cys Thr Gly Gly Ala Gly Thr Gly Gly Gly Thr Cys 
    130                 135                 140                 


Gly Cys Cys Thr Ala Thr Ala Thr Thr Thr Ala Cys Ala Ala Gly Gly 
145                 150                 155                 160 


Ala Thr Gly Gly Thr Gly Gly Thr Ala Gly Thr Gly Ala Cys Ala Cys 
                165                 170                 175     


Ala Gly Cys Ala Thr Ala Cys Gly Ala Gly Ala Cys Ala Gly Cys Gly 
            180                 185                 190         


Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys Gly Thr Gly Cys Cys Ala 
        195                 200                 205             


Cys Cys Ala Thr Cys Thr Cys Gly Ala Gly Gly Gly Ala Cys Gly Ala 
    210                 215                 220                 


Cys Gly Gly Gly Cys Ala Gly Ala Gly Thr Ala Cys Gly Ala Thr Gly 
225                 230                 235                 240 


Ala Gly Gly Cys Thr Gly Cys Ala Gly Cys Thr Gly Ala Ala Cys Ala 
                245                 250                 255     


Ala Cys Cys Thr Cys Ala Gly Gly Gly Cys Thr Gly Ala Gly Gly Ala 
            260                 265                 270         


Cys Ala Cys Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala Cys 
        275                 280                 285             


Thr Gly Thr Gly Cys Cys Ala Gly Ala Gly Gly Thr Ala Thr Thr Gly 
    290                 295                 300                 


Gly Thr Ala Thr Thr Gly Gly Thr Ala Ala Cys Ala Thr Cys Gly Ala 
305                 310                 315                 320 


Cys Gly Cys Ala Thr Gly Gly Gly Gly Cys Cys Ala Cys Gly Gly Gly 
                325                 330                 335     


Ala Cys Cys Gly Ala Ala Gly Thr Cys Ala Thr Cys Gly Thr Cys Thr 
            340                 345                 350         


Cys Cys Thr Cys Cys 
        355         


<210>  486
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  486

Ser Gly Asn Ser Asp Asn Asn Tyr Phe Gly 
1               5                   10  


<210>  487
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  487

Gly Asn Asp Lys Arg Pro Ser 
1               5           


<210>  488
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  488

Gly Ser Tyr Asp Thr Tyr Val Asn Asp Asp Met 
1               5                   10      


<210>  489
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  489

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Gly Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Asn Ser Asp Asn Asn Tyr Phe Gly Trp Phe 
            20                  25                  30          


Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Gly Asn 
        35                  40                  45              


Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser 
    50                  55                  60                  


Gly Ser Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu 
65                  70                  75                  80  


Ala Val Tyr Phe Cys Gly Ser Tyr Asp Thr Tyr Val Asn Asp Asp Met 
                85                  90                  95      


Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105     


<210>  490
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  490
gccctgactc agccgtcctc ggtgtcagca aacccgggag gaaccgtcga gatcacctgc       60

tccgggaata gtgacaataa ctactttggc tggttccagc agaagtctcc tggcagtgcc      120

ccagtcactg tgatctatgg caacgacaag agaccctcgg acatcccttc acgattctcc      180

ggttccaaat ccggctccac ggccacatta accatcactg gggtccaagc cgacgacgag      240

gctgtctatt tctgtgggag ctacgacacc tatgtcaatg atgacatgtt tggggccggg      300

acaaccctga ccgtcctt                                                    318


<210>  491
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab94 (MCT1 3311 B04) - CDR1-HC

<400>  491

Gly Phe Thr Phe Ser Ser Phe 
1               5           


<210>  492
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  492

Ser Asn Asp Gly Gly Gly 
1               5       


<210>  493
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  493

Gly Gly Gly Ala Ser Ser Ile Asp Ala 
1               5                   


<210>  494
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  494

Ala Val Thr Leu Asp Glu Ser Glu Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Gly Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Val Ser Asn Asp Gly Gly Gly Thr Trp Tyr Ala Thr Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Lys Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ala Ser Ser Ile Asp Ala Trp Gly His Gly Thr 
            100                 105                 110         


Glu Val Ile Val Ser Ser 
        115             


<210>  495
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  495
gccgtgacgt tggacgagtc cgagggcggc ctccagacgc ccggaggaac gctcagcctc       60

gtctgcaagg gctccgggtt caccttcagc agcttcaaca tgttctgggt gcgacaggcg      120

cccggcaagg ggctggaatt cgtcgctgct gttagcaatg atggtggtgg cacatggtac      180

gcgacggcgg tgaagggccg tgccaccatc tcgaaggaca acgggcagag cacagtgagg      240

ctgcagctga acaacctcag ggctgaggac accggcacct actactgcgc cagaggtggt      300

ggtgccagta gtatcgacgc atggggccac gggaccgaag tcatcgtctc ctcc            354


<210>  496
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  496

Ser Gly Gly Ser Gly Arg Tyr Gly 
1               5               


<210>  497
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  497

Ala Asn Thr Lys Arg Pro Ser 
1               5           


<210>  498
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  498

Gly Ser Ile Asp Asn Asn Tyr Val Gly Ile 
1               5                   10  


<210>  499
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  499

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Ser Gly Arg Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Arg Ala Asn Thr Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Ser Ile Asp Asn Asn Tyr Val Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  500
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  500
gccctgactc agccgtcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc       60

tccgggggta gtggcaggta cggctggtat cagcagaagt cacctggcag tgcccctgtc      120

actgtgatca gggctaacac caagagaccc tcggacatcc cttcacgatt ctccggttcc      180

aaatccggct ccacgggcac attaaccatc actggggtcc aagtcgagga cgaggctgtc      240

tatttctgtg ggagcataga caacaactat gttggtatat ttggggccgg gacaaccctg      300

accgtccta                                                              309


<210>  501
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-HC

<400>  501

Gly Phe Thr Ile Ser Ser Tyr 
1               5           


<210>  502
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-HC

<400>  502

Ser Gly Ser Gly Arg Tyr 
1               5       


<210>  503
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-HC

<400>  503

Asp Gly Gly Gly Asn Tyr Trp Asn Ala Ala Gly Gly Ile Asp Ala 
1               5                   10                  15  


<210>  504
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Protein

<400>  504

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Gly Ser Gly Phe Thr Ile Ser Ser Tyr 
            20                  25                  30          


Thr Met Gln Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Ser Ile Ser Gly Ser Gly Arg Tyr Thr Gly Tyr Gly Ala Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Gly Asn Tyr Trp Asn Ala Ala Gly Gly Ile Asp 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  505
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC DNA

<400>  505
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggaac gctcagcctc       60

gtctgcaagg gctccgggtt caccatcagc agttacacca tgcagtgggt gcgacaggcg      120

cccgacaagg ggttggaata tgtcgccagt attagcggca gtggtagata cacaggctac      180

ggggcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacagtgagg      240

ctgcagctga acaacctcag ggctgaggac accggcacct actactgcgc caaagatggt      300

ggtggtaatt actggaatgc tgctggtggt atcgacgcat ggggccacgg gaccgaagtc      360

atcgtctcct cc                                                          372


<210>  506
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-LC

<400>  506

Ser Gly Gly Ser Ser Thr Tyr Gly 
1               5               


<210>  507
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-LC

<400>  507

Asn Asp Asp Glu Arg Pro Ser 
1               5           


<210>  508
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-LC

<400>  508

Gly Asn Glu Asp Ser Ser Ala Gly Lys Gly Gly Ile 
1               5                   10          


<210>  509
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Protein

<400>  509

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Ser Ser Thr Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Asn Asp Asp Glu 
        35                  40                  45              


Arg Pro Ser Asn Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser Asp Phe 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Asp Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Asn Glu Asp Ser Ser Ala Gly Lys Gly Gly Ile Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  510
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC DNA

<400>  510
gccctgactc agccgtcctc ggtgtcagcg aacctgggag gaaccgtcga gatcacctgc       60

tccgggggta gcagcaccta tggctggtac cagcagaagt ctcctggcag tgcccctgtc      120

actctgattt ataatgatga tgagagaccc tcgaacatcc cttcacgatt ctccggttcc      180

acatccgact tcacgggcac attaaccatc actggggtcc aagccgacga cgaggctgtc      240

tatttctgtg ggaatgaaga cagcagtgct ggtaaaggtg gcatatttgg ggccgggaca      300

accctgaccg tccta                                                       315


<210>  511
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Heavy Chain

<400>  511

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  512
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Heavy Chain

<400>  512

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  513
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Heavy Chain

<400>  513

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  514
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Heavy Chain

<400>  514

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  515
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Heavy Chain

<400>  515

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  516
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Heavy Chain

<400>  516

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  517
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Heavy Chain

<400>  517

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  518
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Light Chain

<400>  518

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  519
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Light Chain

<400>  519

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  520
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Light Chain

<400>  520

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  521
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Light Chain

<400>  521

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  522
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Light Chain

<400>  522

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  523
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Light Chain

<400>  523

Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
1               5                   10                  15      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        35                  40                  45              


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    50                  55                  60                  


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
65                  70                  75                  80  


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                85                  90                  95      


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            100                 105                 110         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        115                 120                 125             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    130                 135                 140                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
145                 150             


<210>  524
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Light Chain

<400>  524

Asn Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  525
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Anti-MCT1 antibody (Ab1 or INX310)

<400>  525

Gln Val Gln Leu Lys Ala Thr Gly Pro Gly Leu Val Gln Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Ser Glu Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Lys Thr Asp Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125     


<210>  526
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Anti-MCT1 Ab _VL

<400>  526

Asn Ile His Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Phe Gly Glu Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  527
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-MCT1 antibody 1_VH

<400>  527

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  528
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-MCT1 antibody 1, 2 and 3 _VL

<400>  528

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  529
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-MCT1 antibody 2_VH

<400>  529

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  530
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-MCT1 antibody 1, 2 and 3 _VL

<400>  530

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  531
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-MCT1 antibody 3 _VH

<400>  531

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


His Leu Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Ser Ser Gly Asn Thr Glu Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Trp Tyr His Gly Thr Tyr Tyr Ser Pro Gly Tyr Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  532
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-MCT1 antibody 1, 2 and 3 _VL

<400>  532

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Thr Pro Ala Leu Leu Ile 
        35                  40                  45              


Tyr Asn Arg His Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Ser Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  533
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  >IgG1_INX_Silent

<400>  533

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Arg Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


