                         SEQUENCE LISTING

<110>  O'Neill, Kim
 
<120>  MODIFIED MACROPHAGES AND MACROPHAGE PRECURSORS 
	AND ASSOCIATED METHODS


<130>  10494-07847 PCT

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 
            20                  25                  30          


Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 
        35                  40                  45              


Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 
    50                  55                  60                  


Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 
65                  70                  75                  80  


Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 
                85                  90                  95      


Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 
            100                 105                 110         


Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 
        115                 120                 125             


His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 
    130                 135                 140                 


Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 
                165                 170                 175     


Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 
            180                 185                 190         


Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 
        195                 200                 205             


Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 
    210                 215                 220                 


Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 
225                 230                 235                 240 


Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 
                245                 250                 255     


Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 
            260                 265                 270         


Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 
        275                 280                 285             


Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 
    290                 295                 300                 


Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 
305                 310                 315                 320 


Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 
                325                 330                 335     


Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 
            340                 345                 350         


Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 
        355                 360                 365             


Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 
    370                 375                 380                 


Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 
385                 390                 395                 400 


Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 
                405                 410                 415     


Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 
            420                 425                 430         


Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 
        435                 440                 445             


Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 
    450                 455                 460                 


Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 
465                 470                 475                 480 


Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 
                485                 490                 495     


Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 
            500                 505                 510         


Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 
        515                 520                 525             


Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 
    530                 535                 540                 


Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 
545                 550                 555                 560 


Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 
                565                 570                 575     


Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 
            580                 585                 590         


Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 
        595                 600                 605             


Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 
    610                 615                 620                 


Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 
625                 630                 635                 640 


Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 
                645                 650                 655     


Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 
            660                 665                 670         


Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 
        675                 680                 685             


Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 
    690                 695                 700                 


Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
705                 710                 715                 720 


Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 
                725                 730                 735     


Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 
            740                 745                 750         


Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 
        755                 760                 765             


Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 
    770                 775                 780                 


Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 
785                 790                 795                 800 


Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 
                805                 810                 815     


Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 
            820                 825                 830         


His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 
        835                 840                 845             


Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 
    850                 855                 860                 


Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 
865                 870                 875                 880 


Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 
                885                 890                 895     


Leu Gly Ser Lys Asn Ser Val His 
            900                 


<210>  2
<211>  2715
<212>  DNA
<213>  Homo sapiens

<400>  2
atgagacaga ctttgccttg tatctacttt tgggggggcc ttttgccctt tgggatgctg       60

tgtgcatcct ccaccaccaa gtgcactgtt agccatgaag ttgctgactg cagccacctg      120

aagttgactc aggtacccga tgatctaccc acaaacataa cagtgttgaa ccttacccat      180

aatcaactca gaagattacc agccgccaac ttcacaaggt atagccagct aactagcttg      240

gatgtaggat ttaacaccat ctcaaaactg gagccagaat tgtgccagaa acttcccatg      300

ttaaaagttt tgaacctcca gcacaatgag ctatctcaac tttctgataa aacctttgcc      360

ttctgcacga atttgactga actccatctc atgtccaact caatccagaa aattaaaaat      420

aatccctttg tcaagcagaa gaatttaatc acattagatc tgtctcataa tggcttgtca      480

tctacaaaat taggaactca ggttcagctg gaaaatctcc aagagcttct attatcaaac      540

aataaaattc aagcgctaaa aagtgaagaa ctggatatct ttgccaattc atctttaaaa      600

aaattagagt tgtcatcgaa tcaaattaaa gagttttctc cagggtgttt tcacgcaatt      660

ggaagattat ttggcctctt tctgaacaat gtccagctgg gtcccagcct tacagagaag      720

ctatgtttgg aattagcaaa cacaagcatt cggaatctgt ctctgagtaa cagccagctg      780

tccaccacca gcaatacaac tttcttggga ctaaagtgga caaatctcac tatgctcgat      840

ctttcctaca acaacttaaa tgtggttggt aacgattcct ttgcttggct tccacaacta      900

gaatatttct tcctagagta taataatata cagcatttgt tttctcactc tttgcacggg      960

cttttcaatg tgaggtacct gaatttgaaa cggtctttta ctaaacaaag tatttccctt     1020

gcctcactcc ccaagattga tgatttttct tttcagtggc taaaatgttt ggagcacctt     1080

aacatggaag ataatgatat tccaggcata aaaagcaata tgttcacagg attgataaac     1140

ctgaaatact taagtctatc caactccttt acaagtttgc gaactttgac aaatgaaaca     1200

tttgtatcac ttgctcattc tcccttacac atactcaacc taaccaagaa taaaatctca     1260

aaaatagaga gtgatgcttt ctcttggttg ggccacctag aagtacttga cctgggcctt     1320

aatgaaattg ggcaagaact cacaggccag gaatggagag gtctagaaaa tattttcgaa     1380

atctatcttt cctacaacaa gtacctgcag ctgactagga actcctttgc cttggtccca     1440

agccttcaac gactgatgct ccgaagggtg gcccttaaaa atgtggatag ctctccttca     1500

ccattccagc ctcttcgtaa cttgaccatt ctggatctaa gcaacaacaa catagccaac     1560

ataaatgatg acatgttgga gggtcttgag aaactagaaa ttctcgattt gcagcataac     1620

aacttagcac ggctctggaa acacgcaaac cctggtggtc ccatttattt cctaaagggt     1680

ctgtctcacc tccacatcct taacttggag tccaacggct ttgacgagat cccagttgag     1740

gtcttcaagg atttatttga actaaagatc atcgatttag gattgaataa tttaaacaca     1800

cttccagcat ctgtctttaa taatcaggtg tctctaaagt cattgaacct tcagaagaat     1860

ctcataacat ccgttgagaa gaaggttttc gggccagctt tcaggaacct gactgagtta     1920

gatatgcgct ttaatccctt tgattgcacg tgtgaaagta ttgcctggtt tgttaattgg     1980

attaacgaga cccataccaa catccctgag ctgtcaagcc actacctttg caacactcca     2040

cctcactatc atgggttccc agtgagactt tttgatacat catcttgcaa agacagtgcc     2100

ccctttgaac tctttttcat gatcaatacc agtatcctgt tgatttttat ctttattgta     2160

cttctcatcc actttgaggg ctggaggata tctttttatt ggaatgtttc agtacatcga     2220

gttcttggtt tcaaagaaat agacagacag acagaacagt ttgaatatgc agcatatata     2280

attcatgcct ataaagataa ggattgggtc tgggaacatt tctcttcaat ggaaaaggaa     2340

gaccaatctc tcaaattttg tctggaagaa agggactttg aggcgggtgt ttttgaacta     2400

gaagcaattg ttaacagcat caaaagaagc agaaaaatta tttttgttat aacacaccat     2460

ctattaaaag acccattatg caaaagattc aaggtacatc atgcagttca acaagctatt     2520

gaacaaaatc tggattccat tatattggtt ttccttgagg agattccaga ttataaactg     2580

aaccatgcac tctgtttgcg aagaggaatg tttaaatctc actgcatctt gaactggcca     2640

gttcagaaag aacggatagg tgcctttcgt cataaattgc aagtagcact tggatccaaa     2700

aactctgtac attaa                                                      2715


<210>  3
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  4
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val Ala Val 
1               5                   10                  15      


Leu Val Tyr Lys Phe Tyr Phe 
            20              


<210>  5
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  5

His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
1               5                   10                  15      


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
            20                  25                  30          


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
        35                  40                  45              


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
    50                  55                  60                  


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
65                  70                  75                  80  


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
                85                  90                  95      


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
            100                 105                 110         


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
        115                 120                 125             


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
    130                 135                 140                 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
145                 150                 155                 160 


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
                165                 170                 175     


Trp Gln Glu Ala Thr Ser Ile 
            180             


<210>  6
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  6
atgatgtctg cctcgcgcct ggctgggact ctgatcccag ccatggcctt cctctcctgc       60

gtgagaccag aaagctggga gccctgcgtg gaggtggttc ctaatattac ttatcaatgc      120

atggagctga atttctacaa aatccccgac aacctcccct tctcaaccaa gaacctggac      180

ctgagcttta atcccctgag gcatttaggc agctatagct tcttcagttt cccagaactg      240

caggtgctgg atttatccag gtgtgaaatc cagacaattg aagatggggc atatcagagc      300

ctaagccacc tctctacctt aatattgaca ggaaacccca tccagagttt agccctggga      360

gccttttctg gactatcaag tttacagaag ctggtggctg tggagacaaa tctagcatct      420

ctagagaact tccccattgg acatctcaaa actttgaaag aacttaatgt ggctcacaat      480

cttatccaat ctttcaaatt acctgagtat ttttctaatc tgaccaatct agagcacttg      540

gacctttcca gcaacaagat tcaaagtatt tattgcacag acttgcgggt tctacatcaa      600

atgcccctac tcaatctctc tttagacctg tccctgaacc ctatgaactt tatccaacca      660

ggtgcattta aagaaattag gcttcataag ctgactttaa gaaataattt tgatagttta      720

aatgtaatga aaacttgtat tcaaggtctg gctggtttag aagtccatcg tttggttctg      780

ggagaattta gaaatgaagg aaacttggaa aagtttgaca aatctgctct agagggcctg      840

tgcaatttga ccattgaaga attccgatta gcatacttag actactacct cgatgatatt      900

attgacttat ttaattgttt gacaaatgtt tcttcatttt ccctggtgag tgtgactatt      960

gaaagggtaa aagacttttc ttataatttc ggatggcaac atttagaatt agttaactgt     1020

aaatttggac agtttcccac attgaaactc aaatctctca aaaggcttac tttcacttcc     1080

aacaaaggtg ggaatgcttt ttcagaagtt gatctaccaa gccttgagtt tctagatctc     1140

agtagaaatg gcttgagttt caaaggttgc tgttctcaaa gtgattttgg gacaaccagc     1200

ctaaagtatt tagatctgag cttcaatggt gttattacca tgagttcaaa cttcttgggc     1260

ttagaacaac tagaacatct ggatttccag cattccaatt tgaaacaaat gagtgagttt     1320

tcagtattcc tatcactcag aaacctcatt taccttgaca tttctcatac tcacaccaga     1380

gttgctttca atggcatctt caatggcttg tccagtctcg aagtcttgaa aatggctggc     1440

aattctttcc aggaaaactt ccttccagat atcttcacag agctgagaaa cttgaccttc     1500

ctggacctct ctcagtgtca actggagcag ttgtctccaa cagcatttaa ctcactctcc     1560

agtcttcagg tactaaatat gagccacaac aacttctttt cattggatac gtttccttat     1620

aagtgtctga actccctcca ggttcttgat tacagtctca atcacataat gacttccaaa     1680

aaacaggaac tacagcattt tccaagtagt ctagctttct taaatcttac tcagaatgac     1740

tttgcttgta cttgtgaaca ccagagtttc ctgcaatgga tcaaggacca gaggcagctc     1800

ttggtggaag ttgaacgaat ggaatgtgca acaccttcag ataagcaggg catgcctgtg     1860

ctgagtttga atatcacctg tcagatgaat aagaccatca ttggtgtgtc ggtcctcagt     1920

gtgcttgtag tatctgttgt agcagttctg gtctataagt tctattttca cctgatgctt     1980

cttgctggct gcataaagta tggtagaggt gaaaacatct atgatgcctt tgttatctac     2040

tcaagccagg atgaggactg ggtaaggaat gagctagtaa agaatttaga agaaggggtg     2100

cctccatttc agctctgcct tcactacaga gactttattc ccggtgtggc cattgctgcc     2160

aacatcatcc atgaaggttt ccataaaagc cgaaaggtga ttgttgtggt gtcccagcac     2220

ttcatccaga gccgctggtg tatctttgaa tatgagattg ctcagacctg gcagtttctg     2280

agcagtcgtg ctggtatcat cttcattgtc ctgcagaagg tggagaagac cctgctcagg     2340

cagcaggtgg agctgtaccg ccttctcagc aggaacactt acctggagtg ggaggacagt     2400

gtcctggggc ggcacatctt ctggagacga ctcagaaaag ccctgctgga tggtaaatca     2460

tggaatccag aaggaacagt gggtacagga tgcaattggc aggaagcaac atctatctga     2520


<210>  7
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln 
                485                 490                 495     


Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp 
            500                 505                 510         


Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu 
        515                 520                 525             


Ile Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu 
    530                 535                 540                 


Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr 
545                 550                 555                 560 


Ala Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn 
                565                 570                 575     


Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr 
            580                 585                 590         


Lys Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile 
        595                 600                 605             


Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu 
    610                 615                 620                 


Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn 
625                 630                 635                 640 


Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp 
                645                 650                 655     


Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly 
            660                 665                 670         


Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 
        675                 680                 685             


Ser Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu 
    690                 695                 700                 


Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 
705                 710                 715                 720 


Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg 
                725                 730                 735     


Ser Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu 
            740                 745                 750         


Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro 
        755                 760                 765             


Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg 
    770                 775                 780                 


Phe Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His 
785                 790                 795                 800 


Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 
                805                 810                 815     


Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 
            820                 825                 830         


Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser 
        835                 840                 845             


Val Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe 
    850                 855                 860                 


Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly 
865                 870                 875                 880 


Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val 
                885                 890                 895     


Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu 
            900                 905                 910         


Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu 
        915                 920                 925             


Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser 
    930                 935                 940                 


Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 
945                 950                 955                 960 


Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln 
                965                 970                 975     


Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu 
            980                 985                 990         


Lys Pro Phe Gln Lys Ser Lys Phe  Leu Gln Leu Arg Lys  Arg Leu Cys 
        995                 1000                 1005             


Gly Ser  Ser Val Leu Glu Trp  Pro Thr Asn Pro Gln  Ala His Pro 
    1010                 1015                 1020             


Tyr Phe  Trp Gln Cys Leu Lys  Asn Ala Leu Ala Thr  Asp Asn His 
    1025                 1030                 1035             


Val Ala  Tyr Ser Gln Val Phe  Lys Glu Thr Val 
    1040                 1045                 


<210>  8
<211>  3150
<212>  DNA
<213>  Homo sapiens

<400>  8
atggtgtttc caatgtggac actgaagaga caaattctta tcctttttaa cataatccta       60

atttccaaac tccttggggc tagatggttt cctaaaactc tgccctgtga tgtcactctg      120

gatgttccaa agaaccatgt gatcgtggac tgcacagaca agcatttgac agaaattcct      180

ggaggtattc ccacgaacac cacgaacctc accctcacca ttaaccacat accagacatc      240

tccccagcgt cctttcacag actggaccat ctggtagaga tcgatttcag atgcaactgt      300

gtacctattc cactggggtc aaaaaacaac atgtgcatca agaggctgca gattaaaccc      360

agaagcttta gtggactcac ttatttaaaa tccctttacc tggatggaaa ccagctacta      420

gagataccgc agggcctccc gcctagctta cagcttctca gccttgaggc caacaacatc      480

ttttccatca gaaaagagaa tctaacagaa ctggccaaca tagaaatact ctacctgggc      540

caaaactgtt attatcgaaa tccttgttat gtttcatatt caatagagaa agatgccttc      600

ctaaacttga caaagttaaa agtgctctcc ctgaaagata acaatgtcac agccgtccct      660

actgttttgc catctacttt aacagaacta tatctctaca acaacatgat tgcaaaaatc      720

caagaagatg attttaataa cctcaaccaa ttacaaattc ttgacctaag tggaaattgc      780

cctcgttgtt ataatgcccc atttccttgt gcgccgtgta aaaataattc tcccctacag      840

atccctgtaa atgcttttga tgcgctgaca gaattaaaag ttttacgtct acacagtaac      900

tctcttcagc atgtgccccc aagatggttt aagaacatca acaaactcca ggaactggat      960

ctgtcccaaa acttcttggc caaagaaatt ggggatgcta aatttctgca ttttctcccc     1020

agcctcatcc aattggatct gtctttcaat tttgaacttc aggtctatcg tgcatctatg     1080

aatctatcac aagcattttc ttcactgaaa agcctgaaaa ttctgcggat cagaggatat     1140

gtctttaaag agttgaaaag ctttaacctc tcgccattac ataatcttca aaatcttgaa     1200

gttcttgatc ttggcactaa ctttataaaa attgctaacc tcagcatgtt taaacaattt     1260

aaaagactga aagtcataga tctttcagtg aataaaatat caccttcagg agattcaagt     1320

gaagttggct tctgctcaaa tgccagaact tctgtagaaa gttatgaacc ccaggtcctg     1380

gaacaattac attatttcag atatgataag tatgcaagga gttgcagatt caaaaacaaa     1440

gaggcttctt tcatgtctgt taatgaaagc tgctacaagt atgggcagac cttggatcta     1500

agtaaaaata gtatattttt tgtcaagtcc tctgattttc agcatctttc tttcctcaaa     1560

tgcctgaatc tgtcaggaaa tctcattagc caaactctta atggcagtga attccaacct     1620

ttagcagagc tgagatattt ggacttctcc aacaaccggc ttgatttact ccattcaaca     1680

gcatttgaag agcttcacaa actggaagtt ctggatataa gcagtaatag ccattatttt     1740

caatcagaag gaattactca tatgctaaac tttaccaaga acctaaaggt tctgcagaaa     1800

ctgatgatga acgacaatga catctcttcc tccaccagca ggaccatgga gagtgagtct     1860

cttagaactc tggaattcag aggaaatcac ttagatgttt tatggagaga aggtgataac     1920

agatacttac aattattcaa gaatctgcta aaattagagg aattagacat ctctaaaaat     1980

tccctaagtt tcttgccttc tggagttttt gatggtatgc ctccaaatct aaagaatctc     2040

tctttggcca aaaatgggct caaatctttc agttggaaga aactccagtg tctaaagaac     2100

ctggaaactt tggacctcag ccacaaccaa ctgaccactg tccctgagag attatccaac     2160

tgttccagaa gcctcaagaa tctgattctt aagaataatc aaatcaggag tctgacgaag     2220

tattttctac aagatgcctt ccagttgcga tatctggatc tcagctcaaa taaaatccag     2280

atgatccaaa agaccagctt cccagaaaat gtcctcaaca atctgaagat gttgcttttg     2340

catcataatc ggtttctgtg cacctgtgat gctgtgtggt ttgtctggtg ggttaaccat     2400

acggaggtga ctattcctta cctggccaca gatgtgactt gtgtggggcc aggagcacac     2460

aagggccaaa gtgtgatctc cctggatctg tacacctgtg agttagatct gactaacctg     2520

attctgttct cactttccat atctgtatct ctctttctca tggtgatgat gacagcaagt     2580

cacctctatt tctgggatgt gtggtatatt taccatttct gtaaggccaa gataaagggg     2640

tatcagcgtc taatatcacc agactgttgc tatgatgctt ttattgtgta tgacactaaa     2700

gacccagctg tgaccgagtg ggttttggct gagctggtgg ccaaactgga agacccaaga     2760

gagaaacatt ttaatttatg tctcgaggaa agggactggt taccagggca gccagttctg     2820

gaaaaccttt cccagagcat acagcttagc aaaaagacag tgtttgtgat gacagacaag     2880

tatgcaaaga ctgaaaattt taagatagca ttttacttgt cccatcagag gctcatggat     2940

gaaaaagttg atgtgattat cttgatattt cttgagaagc cctttcagaa gtccaagttc     3000

ctccagctcc ggaaaaggct ctgtgggagt tctgtccttg agtggccaac aaacccgcaa     3060

gctcacccat acttctggca gtgtctaaag aacgccctgg ccacagacaa tcatgtggcc     3120

tatagtcagg tgttcaagga aacggtctag                                      3150


<210>  9
<211>  1041
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu 
1               5                   10                  15      


Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe Ser Arg 
            20                  25                  30          


Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile Ala Glu 
        35                  40                  45              


Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly Lys Tyr 
    50                  55                  60                  


Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile Thr Asn 
65                  70                  75                  80  


Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu Asn His 
                85                  90                  95      


Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln Ser Asn 
            100                 105                 110         


Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn Leu Arg 
        115                 120                 125             


Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser Gly Leu 
    130                 135                 140                 


Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn 
145                 150                 155                 160 


Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr 
                165                 170                 175     


Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile 
            180                 185                 190         


Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu 
        195                 200                 205             


Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu 
    210                 215                 220                 


Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu Glu 
225                 230                 235                 240 


Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly Asn 
                245                 250                 255     


Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys Asp Gly 
            260                 265                 270         


Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln 
        275                 280                 285             


Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala 
    290                 295                 300                 


Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu Glu Phe 
305                 310                 315                 320 


Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu 
                325                 330                 335     


Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser 
            340                 345                 350         


Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser 
        355                 360                 365             


Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu Arg Glu 
    370                 375                 380                 


Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr Ile Asn 
385                 390                 395                 400 


Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn 
                405                 410                 415     


Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro 
            420                 425                 430         


Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln 
        435                 440                 445             


Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His 
    450                 455                 460                 


Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala 
465                 470                 475                 480 


Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe Ile 
                485                 490                 495     


Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu Asn Leu 
            500                 505                 510         


Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe Ser Ala 
        515                 520                 525             


Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu Asp Phe 
    530                 535                 540                 


Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val Leu Asp 
545                 550                 555                 560 


Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr His His 
                565                 570                 575     


Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn Leu Ser 
            580                 585                 590         


His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu Ser Lys 
        595                 600                 605             


Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile Leu Trp 
    610                 615                 620                 


Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu Lys Asn 
625                 630                 635                 640 


Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile Pro Asn 
                645                 650                 655     


Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His Ile Asn 
            660                 665                 670         


Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln Phe Pro 
        675                 680                 685             


Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe Leu Thr 
    690                 695                 700                 


Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser 
705                 710                 715                 720 


His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu Val Ser 
                725                 730                 735     


Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr Ile Asn 
            740                 745                 750         


Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met Leu Glu 
        755                 760                 765             


Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp Phe Arg 
    770                 775                 780                 


Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu Val Asp 
785                 790                 795                 800 


Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile Val Ser 
                805                 810                 815     


Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile Leu Phe 
            820                 825                 830         


Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala Leu Ala 
        835                 840                 845             


His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu 
    850                 855                 860                 


Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr 
865                 870                 875                 880 


Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp 
                885                 890                 895     


Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn 
            900                 905                 910         


Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile 
        915                 920                 925             


Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe 
    930                 935                 940                 


Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe 
945                 950                 955                 960 


Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile 
                965                 970                 975     


Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu 
            980                 985                 990         


Arg Gln Arg Ile Cys Lys Ser Ser  Ile Leu Gln Trp Pro  Asp Asn Pro 
        995                 1000                 1005             


Lys Ala  Glu Gly Leu Phe Trp  Gln Thr Leu Arg Asn  Val Val Leu 
    1010                 1015                 1020             


Thr Glu  Asn Asp Ser Arg Tyr  Asn Asn Met Tyr Val  Asp Ser Ile 
    1025                 1030                 1035             


Lys Gln  Tyr 
    1040     


<210>  10
<211>  3126
<212>  DNA
<213>  Homo sapiens

<400>  10
atggaaaaca tgttccttca gtcgtcaatg ctgacctgca ttttcctgct aatatctggt       60

tcctgtgagt tatgcgccga agaaaatttt tctagaagct atccttgtga tgagaaaaag      120

caaaatgact cagttattgc agagtgcagc aatcgtcgac tacaggaagt tccccaaacg      180

gtgggcaaat atgtgacaga actagacctg tctgataatt tcatcacaca cataacgaat      240

gaatcatttc aagggctgca aaatctcact aaaataaatc taaaccacaa ccccaatgta      300

cagcaccaga acggaaatcc cggtatacaa tcaaatggct tgaatatcac agacggggca      360

ttcctcaacc taaaaaacct aagggagtta ctgcttgaag acaaccagtt accccaaata      420

ccctctggtt tgccagagtc tttgacagaa cttagtctaa ttcaaaacaa tatatacaac      480

ataactaaag agggcatttc aagacttata aacttgaaaa atctctattt ggcctggaac      540

tgctatttta acaaagtttg cgagaaaact aacatagaag atggagtatt tgaaacgctg      600

acaaatttgg agttgctatc actatctttc aattctcttt cacacgtgcc acccaaactg      660

ccaagctccc tacgcaaact ttttctgagc aacacccaga tcaaatacat tagtgaagaa      720

gatttcaagg gattgataaa tttaacatta ctagatttaa gcgggaactg tccgaggtgc      780

ttcaatgccc catttccatg cgtgccttgt gatggtggtg cttcaattaa tatagatcgt      840

tttgcttttc aaaacttgac ccaacttcga tacctaaacc tctctagcac ttccctcagg      900

aagattaatg ctgcctggtt taaaaatatg cctcatctga aggtgctgga tcttgaattc      960

aactatttag tgggagaaat agcctctggg gcatttttaa cgatgctgcc ccgcttagaa     1020

atacttgact tgtcttttaa ctatataaag gggagttatc cacagcatat taatatttcc     1080

agaaacttct ctaaactttt gtctctacgg gcattgcatt taagaggtta tgtgttccag     1140

gaactcagag aagatgattt ccagcccctg atgcagcttc caaacttatc gactatcaac     1200

ttgggtatta attttattaa gcaaatcgat ttcaaacttt tccaaaattt ctccaatctg     1260

gaaattattt acttgtcaga aaacagaata tcaccgttgg taaaagatac ccggcagagt     1320

tatgcaaata gttcctcttt tcaacgtcat atccggaaac gacgctcaac agattttgag     1380

tttgacccac attcgaactt ttatcatttc acccgtcctt taataaagcc acaatgtgct     1440

gcttatggaa aagccttaga tttaagcctc aacagtattt tcttcattgg gccaaaccaa     1500

tttgaaaatc ttcctgacat tgcctgttta aatctgtctg caaatagcaa tgctcaagtg     1560

ttaagtggaa ctgaattttc agccattcct catgtcaaat atttggattt gacaaacaat     1620

agactagact ttgataatgc tagtgctctt actgaattgt ccgacttgga agttctagat     1680

ctcagctata attcacacta tttcagaata gcaggcgtaa cacatcatct agaatttatt     1740

caaaatttca caaatctaaa agttttaaac ttgagccaca acaacattta tactttaaca     1800

gataagtata acctggaaag caagtccctg gtagaattag ttttcagtgg caatcgcctt     1860

gacattttgt ggaatgatga tgacaacagg tatatctcca ttttcaaagg tctcaagaat     1920

ctgacacgtc tggatttatc ccttaatagg ctgaagcaca tcccaaatga agcattcctt     1980

aatttgccag cgagtctcac tgaactacat ataaatgata atatgttaaa gttttttaac     2040

tggacattac tccagcagtt tcctcgtctc gagttgcttg acttacgtgg aaacaaacta     2100

ctctttttaa ctgatagcct atctgacttt acatcttccc ttcggacact gctgctgagt     2160

cataacagga tttcccacct accctctggc tttctttctg aagtcagtag tctgaagcac     2220

ctcgatttaa gttccaatct gctaaaaaca atcaacaaat ccgcacttga aactaagacc     2280

accaccaaat tatctatgtt ggaactacac ggaaacccct ttgaatgcac ctgtgacatt     2340

ggagatttcc gaagatggat ggatgaacat ctgaatgtca aaattcccag actggtagat     2400

gtcatttgtg ccagtcctgg ggatcaaaga gggaagagta ttgtgagtct ggagctaaca     2460

acttgtgttt cagatgtcac tgcagtgata ttatttttct tcacgttctt tatcaccacc     2520

atggttatgt tggctgccct ggctcaccat ttgttttact gggatgtttg gtttatatat     2580

aatgtgtgtt tagctaaggt aaaaggctac aggtctcttt ccacatccca aactttctat     2640

gatgcttaca tttcttatga caccaaagat gcctctgtta ctgactgggt gataaatgag     2700

ctgcgctacc accttgaaga gagccgagac aaaaacgttc tcctttgtct agaggagagg     2760

gattgggacc cgggattggc catcatcgac aacctcatgc agagcatcaa ccaaagcaag     2820

aaaacagtat ttgttttaac caaaaaatat gcaaaaagct ggaactttaa aacagctttt     2880

tacttggctt tgcagaggct aatggatgag aacatggatg tgattatatt tatcctgctg     2940

gagccagtgt tacagcattc tcagtatttg aggctacggc agcggatctg taagagctcc     3000

atcctccagt ggcctgacaa cccgaaggca gaaggcttgt tttggcaaac tctgagaaat     3060

gtggtcttga ctgaaaatga ttcacggtat aacaatatgt atgtcgattc cattaagcaa     3120

tactaa                                                                3126


<210>  11
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln 
1               5                   10                  15      


Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe 
            20                  25                  30          


Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu 
        35                  40                  45              


Phe Leu Lys Ser Val Pro His Phe Ser Met Ala Ala Pro Arg Gly Asn 
    50                  55                  60                  


Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp 
65                  70                  75                  80  


Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp 
                85                  90                  95      


Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met 
            100                 105                 110         


Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu 
        115                 120                 125             


Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser 
    130                 135                 140                 


Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser 
145                 150                 155                 160 


Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly 
                165                 170                 175     


Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro 
            180                 185                 190         


Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr 
        195                 200                 205             


Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu 
225                 230                 235                 240 


Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg 
                245                 250                 255     


Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe 
            260                 265                 270         


Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly 
        275                 280                 285             


Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe 
    290                 295                 300                 


Arg Gly Leu Gly Asn Leu Arg Val Leu Asp Leu Ser Glu Asn Phe Leu 
305                 310                 315                 320 


Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu 
                325                 330                 335     


Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala 
            340                 345                 350         


His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu 
        355                 360                 365             


Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu 
    370                 375                 380                 


Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met 
385                 390                 395                 400 


Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly 
                405                 410                 415     


Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu 
            420                 425                 430         


Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu 
        435                 440                 445             


Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu 
    450                 455                 460                 


Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser 
465                 470                 475                 480 


Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser 
                485                 490                 495     


His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val 
            500                 505                 510         


Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu 
        515                 520                 525             


Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu 
    530                 535                 540                 


Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly 
545                 550                 555                 560 


Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr 
                565                 570                 575     


Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser 
            580                 585                 590         


Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn 
        595                 600                 605             


Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe 
    610                 615                 620                 


Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu 
625                 630                 635                 640 


His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln 
                645                 650                 655     


Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser 
            660                 665                 670         


Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln 
        675                 680                 685             


Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg 
    690                 695                 700                 


Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe 
705                 710                 715                 720 


Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala 
                725                 730                 735     


Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu 
            740                 745                 750         


Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala 
        755                 760                 765             


Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu 
    770                 775                 780                 


Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser 
785                 790                 795                 800 


Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp 
                805                 810                 815     


Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val 
            820                 825                 830         


Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His 
        835                 840                 845             


Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp 
    850                 855                 860                 


Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln 
865                 870                 875                 880 


Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu 
                885                 890                 895     


Glu Cys Arg Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp 
            900                 905                 910         


Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr 
        915                 920                 925             


Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser 
    930                 935                 940                 


Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu 
945                 950                 955                 960 


Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg 
                965                 970                 975     


Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val 
            980                 985                 990         


Leu Leu Trp Pro His Gln Pro Ser  Gly Gln Arg Ser Phe  Trp Ala Gln 
        995                 1000                 1005             


Leu Gly  Met Ala Leu Thr Arg  Asp Asn His His Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Asn Phe  Cys Gln Gly Pro Thr  Ala Glu 
    1025                 1030         


<210>  12
<211>  3099
<212>  DNA
<213>  Homo sapiens

<400>  12
atgggtttct gccgcagcgc cctgcacccg ctgtctctcc tggtgcaggc catcatgctg       60

gccatgaccc tggccctggg taccttgcct gccttcctac cctgtgagct ccagccccac      120

ggcctggtga actgcaactg gctgttcctg aagtctgtgc cccacttctc catggcagca      180

ccccgtggca atgtcaccag cctttccttg tcctccaacc gcatccacca cctccatgat      240

tctgactttg cccacctgcc cagcctgcgg catctcaacc tcaagtggaa ctgcccgccg      300

gttggcctca gccccatgca cttcccctgc cacatgacca tcgagcccag caccttcttg      360

gctgtgccca ccctggaaga gctaaacctg agctacaaca acatcatgac tgtgcctgcg      420

ctgcccaaat ccctcatatc cctgtccctc agccatacca acatcctgat gctagactct      480

gccagcctcg ccggcctgca tgccctgcgc ttcctattca tggacggcaa ctgttattac      540

aagaacccct gcaggcaggc actggaggtg gccccgggtg ccctccttgg cctgggcaac      600

ctcacccacc tgtcactcaa gtacaacaac ctcactgtgg tgccccgcaa cctgccttcc      660

agcctggagt atctgctgtt gtcctacaac cgcatcgtca aactggcgcc tgaggacctg      720

gccaatctga ccgccctgcg tgtgctcgat gtgggcggaa attgccgccg ctgcgaccac      780

gctcccaacc cctgcatgga gtgccctcgt cacttccccc agctacatcc cgataccttc      840

agccacctga gccgtcttga aggcctggtg ttgaaggaca gttctctctc ctggctgaat      900

gccagttggt tccgtgggct gggaaacctc cgagtgctgg acctgagtga gaacttcctc      960

tacaaatgca tcactaaaac caaggccttc cagggcctaa cacagctgcg caagcttaac     1020

ctgtccttca attaccaaaa gagggtgtcc tttgcccacc tgtctctggc cccttccttc     1080

gggagcctgg tcgccctgaa ggagctggac atgcacggca tcttcttccg ctcactcgat     1140

gagaccacgc tccggccact ggcccgcctg cccatgctcc agactctgcg tctgcagatg     1200

aacttcatca accaggccca gctcggcatc ttcagggcct tccctggcct gcgctacgtg     1260

gacctgtcgg acaaccgcat cagcggagct tcggagctga cagccaccat gggggaggca     1320

gatggagggg agaaggtctg gctgcagcct ggggaccttg ctccggcccc agtggacact     1380

cccagctctg aagacttcag gcccaactgc agcaccctca acttcacctt ggatctgtca     1440

cggaacaacc tggtgaccgt gcagccggag atgtttgccc agctctcgca cctgcagtgc     1500

ctgcgcctga gccacaactg catctcgcag gcagtcaatg gctcccagtt cctgccgctg     1560

accggtctgc aggtgctaga cctgtcccac aataagctgg acctctacca cgagcactca     1620

ttcacggagc taccgcgact ggaggccctg gacctcagct acaacagcca gccctttggc     1680

atgcagggcg tgggccacaa cttcagcttc gtggctcacc tgcgcaccct gcgccacctc     1740

agcctggccc acaacaacat ccacagccaa gtgtcccagc agctctgcag tacgtcgctg     1800

cgggccctgg acttcagcgg caatgcactg ggccatatgt gggccgaggg agacctctat     1860

ctgcacttct tccaaggcct gagcggtttg atctggctgg acttgtccca gaaccgcctg     1920

cacaccctcc tgccccaaac cctgcgcaac ctccccaaga gcctacaggt gctgcgtctc     1980

cgtgacaatt acctggcctt ctttaagtgg tggagcctcc acttcctgcc caaactggaa     2040

gtcctcgacc tggcaggaaa ccagctgaag gccctgacca atggcagcct gcctgctggc     2100

acccggctcc ggaggctgga tgtcagctgc aacagcatca gcttcgtggc ccccggcttc     2160

ttttccaagg ccaaggagct gcgagagctc aaccttagcg ccaacgccct caagacagtg     2220

gaccactcct ggtttgggcc cctggcgagt gccctgcaaa tactagatgt aagcgccaac     2280

cctctgcact gcgcctgtgg ggcggccttt atggacttcc tgctggaggt gcaggctgcc     2340

gtgcccggtc tgcccagccg ggtgaagtgt ggcagtccgg gccagctcca gggcctcagc     2400

atctttgcac aggacctgcg cctctgcctg gatgaggccc tctcctggga ctgtttcgcc     2460

ctctcgctgc tggctgtggc tctgggcctg ggtgtgccca tgctgcatca cctctgtggc     2520

tgggacctct ggtactgctt ccacctgtgc ctggcctggc ttccctggcg ggggcggcaa     2580

agtgggcgag atgaggatgc cctgccctac gatgccttcg tggtcttcga caaaacgcag     2640

agcgcagtgg cagactgggt gtacaacgag cttcgggggc agctggagga gtgccgtggg     2700

cgctgggcac tccgcctgtg cctggaggaa cgcgactggc tgcctggcaa aaccctcttt     2760

gagaacctgt gggcctcggt ctatggcagc cgcaagacgc tgtttgtgct ggcccacacg     2820

gaccgggtca gtggtctctt gcgcgccagc ttcctgctgg cccagcagcg cctgctggag     2880

gaccgcaagg acgtcgtggt gctggtgatc ctgagccctg acggccgccg ctcccgctac     2940

gtgcggctgc gccagcgcct ctgccgccag agtgtcctcc tctggcccca ccagcccagt     3000

ggtcagcgca gcttctgggc ccagctgggc atggccctga ccagggacaa ccaccacttc     3060

tataaccgga acttctgcca gggacccacg gccgaatag                            3099


<210>  13
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
        35                  40                  45              


Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
    50                  55                  60                  


Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
65                  70                  75                  80  


Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
            100                 105                 110         


Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
        115                 120                 125             


Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
    130                 135                 140                 


Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
145                 150                 155                 160 


Lys Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
            180                 185                 190         


Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
        195                 200                 205             


Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
    210                 215                 220                 


Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
225                 230                 235                 240 


Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                245                 250                 255     


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            260                 265                 270         


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        275                 280                 285             


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    290                 295                 300                 


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315         


<210>  14
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  14
atgactatgg agacccaaat gtctcagaat gtatgtccca gaaacctgtg gctgcttcaa       60

ccattgacag ttttgctgct gctggcttct gcagacagtc aagctgcagc tcccccaaag      120

gctgtgctga aacttgagcc cccgtggatc aacgtgctcc aggaggactc tgtgactctg      180

acatgccagg gggctcgcag ccctgagagc gactccattc agtggttcca caatgggaat      240

ctcattccca cccacacgca gcccagctac aggttcaagg ccaacaacaa tgacagcggg      300

gagtacacgt gccagactgg ccagaccagc ctcagcgacc ctgtgcatct gactgtgctt      360

tccgaatggc tggtgctcca gacccctcac ctggagttcc aggagggaga aaccatcatg      420

ctgaggtgcc acagctggaa ggacaagcct ctggtcaagg tcacattctt ccagaatgga      480

aaatcccaga aattctccca tttggatccc accttctcca tcccacaagc aaaccacagt      540

cacagtggtg attaccactg cacaggaaac ataggctaca cgctgttctc atccaagcct      600

gtgaccatca ctgtccaagt gcccagcatg ggcagctctt caccaatggg gatcattgtg      660

gctgtggtca ttgcgactgc tgtagcagcc attgttgctg ctgtagtggc cttgatctac      720

tgcaggaaaa agcggatttc agccaattcc actgatcctg tgaaggctgc ccaatttgag      780

ccacctggac gtcaaatgat tgccatcaga aagagacaac ttgaagaaac caacaatgac      840

tatgaaacag ctgacggcgg ctacatgact ctgaacccca gggcacctac tgacgatgat      900

aaaaacatct acctgactct tcctcccaac gaccatgtca acagtaataa ctaa            954


<210>  15
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  16
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  16
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagggt gctcgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agagcctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcgacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaagg caggaagtat tttcatcata attctgactt ctacattcca      480

aaagccacac tcaaagacag cggctcctac ttctgcaggg ggctttttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctttc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattc gaagctcaac aagagactgg      720

aaggaccata aatttaaatg gagaaaggac cctcaagaca aatga                      765


<210>  17
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  18
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  18
atgattccag cagtggtctt gctcttactc cttttggttg aacaagcagc ggccctggga       60

gagcctcagc tctgctatat cctggatgcc atcctgtttc tgtatggaat tgtcctcacc      120

ctcctctact gtcgactgaa gatccaagtg cgaaaggcag ctataaccag ctatgagaaa      180

tcagatggtg tttacacggg cctgagcacc aggaaccagg agacttacga gactctgaag      240

catgagaaac caccacagta g                                                261


<210>  19
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  20
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  20
atgcgacccg accgcgctga ggctccagga ccgcccgcca tggctgcagg aggtcccggc       60

gcggggtctg cggccccggt ctcctccaca tcctcccttc ccctggctgc tctcaacatg      120

cgagtgcggc gccgcctgtc tctgttcttg aacgtgcgga cacaggtggc ggccgactgg      180

accgcgctgg cggaggagat ggactttgag tacttggaga tccggcaact ggagacacaa      240

gcggacccca ctggcaggct gctggacgcc tggcagggac gccctggcgc ctctgtaggc      300

cgactgctcg agctgcttac caagctgggc cgcgacgacg tgctgctgga gctgggaccc      360

agcattgagg aggattgcca aaagtatatc ttgaagcagc agcaggagga ggctgagaag      420

cctttacagg tggccgctgt agacagcagt gtcccacgga cagcagagct ggcgggcatc      480

accacacttg atgaccccct ggggcatatg cctgagcgtt tcgatgcctt catctgctat      540

tgccccagcg acatccagtt tgtgcaggag atgatccggc aactggaaca gacaaactat      600

cgactgaagt tgtgtgtgtc tgaccgcgat gtcctgcctg gcacctgtgt ctggtctatt      660

gctagtgagc tcatcgaaaa gaggttggct agaaggccac ggggtgggtg ccgccggatg      720

gtggtggttg tctctgatga ttacctgcag agcaaggaat gtgacttcca gaccaaattt      780

gcactcagcc tctctccagg tgcccatcag aagcgactga tccccatcaa gtacaaggca      840

atgaagaaag agttccccag catcctgagg ttcatcactg tctgcgacta caccaacccc      900

tgcaccaaat cttggttctg gactcgcctt gccaaggcct tgtccctgcc ctga            954


<210>  21
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Pro Ala Ala Ala Thr Gly Gly Ser Thr Leu Pro Ser Gly Phe 
1               5                   10                  15      


Ser Val Phe Thr Thr Leu Pro Asp Leu Leu Phe Ile Phe Glu Phe Ile 
            20                  25                  30          


Phe Gly Gly Leu Val Trp Ile Leu Val Ala Ser Ser Leu Val Pro Trp 
        35                  40                  45              


Pro Leu Val Gln Gly Trp Val Met Phe Val Ser Val Phe Cys Phe Val 
    50                  55                  60                  


Ala Thr Thr Thr Leu Ile Ile Leu Tyr Ile Ile Gly Ala His Gly Gly 
65                  70                  75                  80  


Glu Thr Ser Trp Val Thr Leu Asp Ala Ala Tyr His Cys Thr Ala Ala 
                85                  90                  95      


Leu Phe Tyr Leu Ser Ala Ser Val Leu Glu Ala Leu Ala Thr Ile Thr 
            100                 105                 110         


Met Gln Asp Gly Phe Thr Tyr Arg His Tyr His Glu Asn Ile Ala Ala 
        115                 120                 125             


Val Val Phe Ser Tyr Ile Ala Thr Leu Leu Tyr Val Val His Ala Val 
    130                 135                 140                 


Phe Ser Leu Ile Arg Trp Lys Ser Ser 
145                 150             


<210>  22
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  22
atggcccccg cagcggcgac ggggggcagc accctgccca gtggcttctc ggtcttcacc       60

accttgcccg acttgctctt catctttgag tttatcttcg ggggcctggt gtggatcctg      120

gtggcctcct ccctggtgcc ctggcccctg gtccagggct gggtgatgtt cgtgtctgtg      180

ttctgcttcg tggccaccac caccttgatc atcctgtaca taattggagc ccacggtgga      240

gagacttcct gggtcacctt ggacgcagcc taccactgca ccgctgccct cttttacctc      300

agcgcctcag tcctggaggc cctggccacc atcacgatgc aagacggctt cacctacagg      360

cactaccatg aaaacattgc tgccgtggtg ttctcctaca tagccactct gctctacgtg      420

gtccatgcgg tgttctcttt aatcagatgg aagtcttcat aa                         462


<210>  23
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Val Tyr Glu Arg Leu Glu Lys Leu Gln Ala Val Val Ala Gly Val 
        515                 520                 525             


Pro Gly His Ser Glu Ala Ala Ser Cys Ile Pro Pro Ser Pro Gln Glu 
    530                 535                 540                 


Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala Ala Pro 
545                 550                 555                 560 


Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala Ala Glu 
                565                 570                 575     


Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu Ser Leu 
            580                 585                 590         


Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro Ser Cys 
        595                 600                 605             


Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln Gly Asp 
    610                 615                 620                 


Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg Pro Thr 
625                 630                 635                 640 


Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser Ser Glu 
                645                 650                 655     


Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val Gln Lys 
            660                 665                 670         


Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu Leu Ser 
        675                 680                 685             


Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln Gly Pro 
    690                 695                 700                 


Glu Glu Ser Asp Glu Phe Gln Ser 
705                 710         


<210>  24
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  24
atggccgggg ggccgggccc gggggagccc gcagcccccg gcgcccagca cttcttgtac       60

gaggtgccgc cctgggtcat gtgccgcttc tacaaagtga tggacgccct ggagcccgcc      120

gactggtgcc agttcgccgc cctgatcgtg cgcgaccaga ccgagctgcg gctgtgcgag      180

cgctccgggc agcgcacggc cagcgtcctg tggccctgga tcaaccgcaa cgcccgtgtg      240

gccgacctcg tgcacatcct cacgcacctg cagctgctcc gtgcgcggga catcatcaca      300

gcctggcacc ctcccgcccc gcttccgtcc ccaggcacca ctgccccgag gcccagcagc      360

atccctgcac ccgccgaggc cgaggcctgg agcccccgga agttgccatc ctcagcctcc      420

accttcctct ccccagcttt tccaggctcc cagacccatt cagggcctga gctcggcctg      480

gtcccaagcc ctgcttccct gtggcctcca ccgccatctc cagccccttc ttctaccaag      540

ccaggcccag agagctcagt gtccctcctg cagggagccc gcccctttcc gttttgctgg      600

cccctctgtg agatttcccg gggcacccac aacttctcgg aggagctcaa gatcggggag      660

ggtggctttg ggtgcgtgta ccgggcggtg atgaggaaca cggtgtatgc tgtgaagagg      720

ctgaaggaga acgctgacct ggagtggact gcagtgaagc agagcttcct gaccgaggtg      780

gagcagctgt ccaggtttcg tcacccaaac attgtggact ttgctggcta ctgtgctcag      840

aacggcttct actgcctggt gtacggcttc ctgcccaacg gctccctgga ggaccgtctc      900

cactgccaga cccaggcctg cccacctctc tcctggcctc agcgactgga catccttctg      960

ggtacagccc gggcaattca gtttctacat caggacagcc ccagcctcat ccatggagac     1020

atcaagagtt ccaacgtcct tctggatgag aggctgacac ccaagctggg agactttggc     1080

ctggcccggt tcagccgctt tgccgggtcc agccccagcc agagcagcat ggtggcccgg     1140

acacagacag tgcggggcac cctggcctac ctgcccgagg agtacatcaa gacgggaagg     1200

ctggctgtgg acacggacac cttcagcttt ggggtggtag tgctagagac cttggctggt     1260

cagagggctg tgaagacgca cggtgccagg accaagtatc tgaaagacct ggtggaagag     1320

gaggctgagg aggctggagt ggctttgaga agcacccaga gcacactgca agcaggtctg     1380

gctgcagatg cctgggctgc tcccatcgcc atgcagatct acaagaagca cctggacccc     1440

aggcccgggc cctgcccacc tgagctgggc ctgggcctgg gccagctggc ctgctgctgc     1500

ctgcaccgcc gggccaaaag gaggcctcct atgacccagg tgtacgagag gctagagaag     1560

ctgcaggcag tggtggcggg ggtgcccggg cattcggagg ccgccagctg catcccccct     1620

tccccgcagg agaactccta cgtgtccagc actggcagag cccacagtgg ggctgctcca     1680

tggcagcccc tggcagcgcc atcaggagcc agtgcccagg cagcagagca gctgcagaga     1740

ggccccaacc agcccgtgga gagtgacgag agcctaggcg gcctctctgc tgccctgcgc     1800

tcctggcact tgactccaag ctgccctctg gacccagcac ccctcaggga ggccggctgt     1860

cctcaggggg acacggcagg agaatcgagc tgggggagtg gcccaggatc ccggcccaca     1920

gccgtggaag gactggccct tggcagctct gcatcatcgt cgtcagagcc accgcagatt     1980

atcatcaacc ctgcccgaca gaagatggtc cagaagctgg ccctgtacga ggatggggcc     2040

ctggacagcc tgcagctgct gtcgtccagc tccctcccag gcttgggcct ggaacaggac     2100

aggcaggggc ccgaagaaag tgatgaattt cagagctga                            2139


<210>  25
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv fragment

<400>  25

Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
1               5                   10                  15      


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
            20                  25                  30          


Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
        35                  40                  45              


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
                85                  90                  95      


Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
        115                 120                 125             


Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala 
    130                 135                 140                 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser 
145                 150                 155                 160 


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro 
                165                 170                 175     


Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn 
            180                 185                 190         


Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Thr Asp 
        195                 200                 205             


Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu 
    210                 215                 220                 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Val Asp 
                245                 250                 255     


Leu 
    


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Short hinge linker

<400>  26

Met Asn Lys Thr Ile 
1               5   


<210>  27
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long hinge linker

<400>  27

Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln Trp Ile 
1               5                   10                  15      


Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu Cys Ala 
            20                  25                  30          


Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn Ile Thr 
        35                  40                  45              


Cys Gln Met Asn Lys Thr Ile 
    50                  55  


<210>  28
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  30
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  31
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  32
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  33
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated CD8 hinge

<400>  33

Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val 
1               5                   10                  15      


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            20                  25                  30          


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        35                  40                  45              


Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    50                  55                  60                  


Ala Ser Asp Ile 
65              


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS linker

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1-ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS-Linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(313)
<223>  TLR4-Transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (314)..(496)
<223>  TLR4-Cytosolic domain

<400>  35

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val 
    290                 295                 300                 


Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly 
305                 310                 315                 320 


Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile 
                325                 330                 335     


Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn 
            340                 345                 350         


Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp 
        355                 360                 365             


Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe 
    370                 375                 380                 


His Lys Ser Arg Lys Val Ile Val Val Val Ser Gln His Phe Ile Gln 
385                 390                 395                 400 


Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe 
                405                 410                 415     


Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu 
            420                 425                 430         


Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg 
        435                 440                 445             


Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe 
    450                 455                 460                 


Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro 
465                 470                 475                 480 


Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 
                485                 490                 495     


<210>  36
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1-ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS-Linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(295)
<223>  LRR Short Hinge

<220>
<221>  MISC_FEATURE
<222>  (296)..(318)
<223>  TLR4 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (319)..(500)
<223>  TLR4 cytosolic domain

<400>  36

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu 
    290                 295                 300                 


Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu 
305                 310                 315                 320 


Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr 
                325                 330                 335     


Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn 
            340                 345                 350         


Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys 
        355                 360                 365             


Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile 
    370                 375                 380                 


Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser 
385                 390                 395                 400 


Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala 
                405                 410                 415     


Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val 
            420                 425                 430         


Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr 
        435                 440                 445             


Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu 
    450                 455                 460                 


Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly 
465                 470                 475                 480 


Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln 
                485                 490                 495     


Glu Ala Thr Ser 
            500 


<210>  37
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Singal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1-ScFv

<220>
<221>  MISC_FEATURE
<222>  (269)..(551)
<223>  TLR4 cytosolic domain

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS-Linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(345)
<223>  LRR long hinge

<220>
<221>  MISC_FEATURE
<222>  (346)..(368)
<223>  TLR4 transmembrane domain

<400>  37

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
    290                 295                 300                 


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
305                 310                 315                 320 


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
                325                 330                 335     


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
            340                 345                 350         


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
        355                 360                 365             


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
    370                 375                 380                 


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
385                 390                 395                 400 


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
                405                 410                 415     


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
            420                 425                 430         


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
        435                 440                 445             


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
    450                 455                 460                 


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
465                 470                 475                 480 


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
                485                 490                 495     


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
            500                 505                 510         


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
        515                 520                 525             


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
    530                 535                 540                 


Trp Gln Glu Ala Thr Ser Ile 
545                 550     


<210>  38
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(302)
<223>  IgG4 short hinge

<220>
<221>  MISC_FEATURE
<222>  (303)..(325)
<223>  TLR4 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (326)..(508)
<223>  TLR4 cytosolic domain

<400>  38

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Gly 
    290                 295                 300                 


Val Ser Val Leu Ser Val Leu Val Val Ser Val Val Ala Val Leu Val 
305                 310                 315                 320 


Tyr Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr 
                325                 330                 335     


Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln 
            340                 345                 350         


Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly 
        355                 360                 365             


Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly 
    370                 375                 380                 


Val Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe His Lys Ser Arg 
385                 390                 395                 400 


Lys Val Ile Val Val Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys 
                405                 410                 415     


Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg 
            420                 425                 430         


Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu 
        435                 440                 445             


Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu 
    450                 455                 460                 


Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu 
465                 470                 475                 480 


Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val 
                485                 490                 495     


Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 
            500                 505             


<210>  39
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(409)
<223>  IgG4 medium hinge

<220>
<221>  MISC_FEATURE
<222>  (410)..(432)
<223>  TLR4 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (433)..(615)
<223>  TLR4 cytosolic domain

<400>  39

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln 
    290                 295                 300                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
305                 310                 315                 320 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                325                 330                 335     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            340                 345                 350         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        355                 360                 365             


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
    370                 375                 380                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
385                 390                 395                 400 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Gly Val Ser Val Leu Ser 
                405                 410                 415     


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
            420                 425                 430         


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
        435                 440                 445             


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
    450                 455                 460                 


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
465                 470                 475                 480 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
                485                 490                 495     


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
            500                 505                 510         


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
        515                 520                 525             


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
    530                 535                 540                 


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
545                 550                 555                 560 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
                565                 570                 575     


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
            580                 585                 590         


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
        595                 600                 605             


Trp Gln Glu Ala Thr Ser Ile 
    610                 615 


<210>  40
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(518)
<223>  IgG4 long hinge

<220>
<221>  MISC_FEATURE
<222>  (519)..(541)
<223>  TLR4 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (542)..(724)
<223>  TLR4 cytosolic domain

<400>  40

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    290                 295                 300                 


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
305                 310                 315                 320 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                325                 330                 335     


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            340                 345                 350         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln 
        355                 360                 365             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    370                 375                 380                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
385                 390                 395                 400 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                405                 410                 415     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            420                 425                 430         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        435                 440                 445             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    450                 455                 460                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
465                 470                 475                 480 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                485                 490                 495     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            500                 505                 510         


Ser Leu Ser Leu Gly Lys Ile Gly Val Ser Val Leu Ser Val Leu Val 
        515                 520                 525             


Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met 
    530                 535                 540                 


Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp 
545                 550                 555                 560 


Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu 
                565                 570                 575     


Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu 
            580                 585                 590         


His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile 
        595                 600                 605             


His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser Gln 
    610                 615                 620                 


His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln 
625                 630                 635                 640 


Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu 
                645                 650                 655     


Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg 
            660                 665                 670         


Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly 
        675                 680                 685             


Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys 
    690                 695                 700                 


Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu 
705                 710                 715                 720 


Ala Thr Ser Ile 
                


<210>  41
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linkder

<220>
<221>  MISC_FEATURE
<222>  (291)..(358)
<223>  Mutated CD8 hinge

<220>
<221>  MISC_FEATURE
<222>  (359)..(381)
<223>  TLR4 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (382)..(564)
<223>  TLR4 cytosolic domain

<400>  41

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val 
    290                 295                 300                 


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
305                 310                 315                 320 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                325                 330                 335     


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            340                 345                 350         


Asp Phe Ala Ser Asp Ile Ile Gly Val Ser Val Leu Ser Val Leu Val 
        355                 360                 365             


Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met 
    370                 375                 380                 


Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp 
385                 390                 395                 400 


Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu 
                405                 410                 415     


Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu 
            420                 425                 430         


His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile 
        435                 440                 445             


His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser Gln 
    450                 455                 460                 


His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln 
465                 470                 475                 480 


Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu 
                485                 490                 495     


Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg 
            500                 505                 510         


Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly 
        515                 520                 525             


Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys 
    530                 535                 540                 


Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu 
545                 550                 555                 560 


Ala Thr Ser Ile 
                


<210>  42
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Sginal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(358)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (359)..(381)
<223>  TLR4 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (382)..(564)
<223>  TLR4 cytosolic domain

<400>  42

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val 
    290                 295                 300                 


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
305                 310                 315                 320 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                325                 330                 335     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            340                 345                 350         


Asp Phe Ala Cys Asp Ile Ile Gly Val Ser Val Leu Ser Val Leu Val 
        355                 360                 365             


Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met 
    370                 375                 380                 


Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp 
385                 390                 395                 400 


Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu 
                405                 410                 415     


Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu 
            420                 425                 430         


His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile 
        435                 440                 445             


His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser Gln 
    450                 455                 460                 


His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln 
465                 470                 475                 480 


Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu 
                485                 490                 495     


Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg 
            500                 505                 510         


Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly 
        515                 520                 525             


Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys 
    530                 535                 540                 


Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu 
545                 550                 555                 560 


Ala Thr Ser Ile 
                


<210>  43
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(311)
<223>  FCGR3A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (312)..(336)
<223>  FCGR3A cytosolic domain

<220>
<221>  MISC_FEATURE
<222>  (337)..(378)
<223>  FCER1G cytosolic domain

<400>  43

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp 
    290                 295                 300                 


Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg 
305                 310                 315                 320 


Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                325                 330                 335     


Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
            340                 345                 350         


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
        355                 360                 365             


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
    370                 375             


<210>  44
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(358)
<223>  Modified CD8a linker

<220>
<221>  MISC_FEATURE
<222>  (359)..(379)
<223>  FCGR3A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (380)..(404)
<223>  FCGR3A cytosolic domain

<220>
<221>  MISC_FEATURE
<222>  (405)..(446)
<223>  FCER1G cytosolic domain

<400>  44

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val 
    290                 295                 300                 


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
305                 310                 315                 320 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                325                 330                 335     


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            340                 345                 350         


Asp Phe Ala Ser Asp Ile Val Ser Phe Cys Leu Val Met Val Leu Leu 
        355                 360                 365             


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
    370                 375                 380                 


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
385                 390                 395                 400 


Pro Gln Asp Lys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr 
                405                 410                 415     


Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn 
            420                 425                 430         


Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        435                 440                 445     


<210>  45
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(358)
<223>  Portion of CD8 hinge

<220>
<221>  MISC_FEATURE
<222>  (359)..(379)
<223>  FCGR3A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (380)..(404)
<223>  FCGR3A cytosolic domain

<220>
<221>  MISC_FEATURE
<222>  (405)..(446)
<223>  FCER1G cytosolic domain

<400>  45

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val 
    290                 295                 300                 


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
305                 310                 315                 320 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                325                 330                 335     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            340                 345                 350         


Asp Phe Ala Cys Asp Ile Val Ser Phe Cys Leu Val Met Val Leu Leu 
        355                 360                 365             


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
    370                 375                 380                 


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
385                 390                 395                 400 


Pro Gln Asp Lys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr 
                405                 410                 415     


Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn 
            420                 425                 430         


Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        435                 440                 445     


<210>  46
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(303)
<223>  IgG4 short hinge

<220>
<221>  MISC_FEATURE
<222>  (304)..(324)
<223>  FCGR3A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (325)..(349)
<223>  FCGR3A cytosolic domain

<220>
<221>  MISC_FEATURE
<222>  (350)..(391)
<223>  FCER1G cytosolic domain

<400>  46

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Val 
    290                 295                 300                 


Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu 
305                 310                 315                 320 


Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys 
                325                 330                 335     


Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys Arg Leu Lys 
            340                 345                 350         


Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly 
        355                 360                 365             


Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu 
    370                 375                 380                 


Lys His Glu Lys Pro Pro Gln 
385                 390     


<210>  47
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linkder

<220>
<221>  MISC_FEATURE
<222>  (291)..(409)
<223>  IgG4 119 aa hinge

<220>
<221>  MISC_FEATURE
<222>  (410)..(430)
<223>  FCGR3A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (431)..(455)
<223>  FCGR3A cytosolic domain

<220>
<221>  MISC_FEATURE
<222>  (456)..(497)
<223>  FCER1G cytosolic domain

<400>  47

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln 
    290                 295                 300                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
305                 310                 315                 320 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                325                 330                 335     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            340                 345                 350         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        355                 360                 365             


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
    370                 375                 380                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
385                 390                 395                 400 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Val Ser Phe Cys Leu Val Met 
                405                 410                 415     


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
            420                 425                 430         


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
        435                 440                 445             


Arg Lys Asp Pro Gln Asp Lys Arg Leu Lys Ile Gln Val Arg Lys Ala 
    450                 455                 460                 


Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser 
465                 470                 475                 480 


Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro 
                485                 490                 495     


Gln 
    


<210>  48
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric angtigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(519)
<223>  IgG4 long hinge

<220>
<221>  MISC_FEATURE
<222>  (520)..(540)
<223>  FCGR3A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (541)..(565)
<223>  FCGR3A cytosolic domain

<220>
<221>  MISC_FEATURE
<222>  (566)..(607)
<223>  FCER1G cytosolic domain

<400>  48

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    290                 295                 300                 


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
305                 310                 315                 320 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                325                 330                 335     


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            340                 345                 350         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln 
        355                 360                 365             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    370                 375                 380                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
385                 390                 395                 400 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                405                 410                 415     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            420                 425                 430         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        435                 440                 445             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    450                 455                 460                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
465                 470                 475                 480 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                485                 490                 495     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            500                 505                 510         


Ser Leu Ser Leu Gly Lys Ile Val Ser Phe Cys Leu Val Met Val Leu 
        515                 520                 525             


Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile 
    530                 535                 540                 


Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys 
545                 550                 555                 560 


Asp Pro Gln Asp Lys Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile 
                565                 570                 575     


Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg 
            580                 585                 590         


Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        595                 600                 605         


<210>  49
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(312)
<223>  FCGR2A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (313)..(390)
<223>  FCGR2A cytosolic domain

<400>  49

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ile Ile Val Ala Val Val Ile Ala Thr Ala Val Ala Ala Ile 
    290                 295                 300                 


Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser 
305                 310                 315                 320 


Ala Asn Ser Thr Asp Pro Val Lys Ala Ala Gln Phe Glu Pro Pro Gly 
                325                 330                 335     


Arg Gln Met Ile Ala Ile Arg Lys Arg Gln Leu Glu Glu Thr Asn Asn 
            340                 345                 350         


Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met Thr Leu Asn Pro Arg Ala 
        355                 360                 365             


Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu Thr Leu Pro Pro Asn Asp 
    370                 375                 380                 


His Val Asn Ser Asn Asn 
385                 390 


<210>  50
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(358)
<223>  Modified CD8a hinge

<220>
<221>  MISC_FEATURE
<222>  (359)..(380)
<223>  FCGR2A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(458)
<223>  FCGR2A cytosolic domain

<400>  50

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val 
    290                 295                 300                 


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
305                 310                 315                 320 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                325                 330                 335     


Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            340                 345                 350         


Asp Phe Ala Ser Asp Ile Ile Ile Val Ala Val Val Ile Ala Thr Ala 
        355                 360                 365             


Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg Lys 
    370                 375                 380                 


Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala Gln Phe 
385                 390                 395                 400 


Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln Leu Glu 
                405                 410                 415     


Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met Thr Leu 
            420                 425                 430         


Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu Thr Leu 
        435                 440                 445             


Pro Pro Asn Asp His Val Asn Ser Asn Asn 
    450                 455             


<210>  51
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(358)
<223>  Portion of CD8a linker

<220>
<221>  MISC_FEATURE
<222>  (359)..(380)
<223>  FCGR2A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (381)..(458)
<223>  FCGR2A cytosolic domain

<400>  51

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val 
    290                 295                 300                 


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
305                 310                 315                 320 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                325                 330                 335     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            340                 345                 350         


Asp Phe Ala Cys Asp Ile Ile Ile Val Ala Val Val Ile Ala Thr Ala 
        355                 360                 365             


Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg Lys 
    370                 375                 380                 


Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala Gln Phe 
385                 390                 395                 400 


Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln Leu Glu 
                405                 410                 415     


Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met Thr Leu 
            420                 425                 430         


Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu Thr Leu 
        435                 440                 445             


Pro Pro Asn Asp His Val Asn Ser Asn Asn 
    450                 455             


<210>  52
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(303)
<223>  IgG4 short hinge

<220>
<221>  MISC_FEATURE
<222>  (304)..(325)
<223>  FCGR2A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (326)..(403)
<223>  FCGR2A cytosolic domain

<400>  52

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Ile 
    290                 295                 300                 


Ile Val Ala Val Val Ile Ala Thr Ala Val Ala Ala Ile Val Ala Ala 
305                 310                 315                 320 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser 
                325                 330                 335     


Thr Asp Pro Val Lys Ala Ala Gln Phe Glu Pro Pro Gly Arg Gln Met 
            340                 345                 350         


Ile Ala Ile Arg Lys Arg Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu 
        355                 360                 365             


Thr Ala Asp Gly Gly Tyr Met Thr Leu Asn Pro Arg Ala Pro Thr Asp 
    370                 375                 380                 


Asp Asp Lys Asn Ile Tyr Leu Thr Leu Pro Pro Asn Asp His Val Asn 
385                 390                 395                 400 


Ser Asn Asn 
            


<210>  53
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK1 ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(409)
<223>  IgG4 119 aa hinge

<220>
<221>  MISC_FEATURE
<222>  (410)..(431)
<223>  FCGR2A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (432)..(509)
<223>  FCGR2A cytosolic domain

<400>  53

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln 
    290                 295                 300                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
305                 310                 315                 320 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                325                 330                 335     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            340                 345                 350         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        355                 360                 365             


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
    370                 375                 380                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
385                 390                 395                 400 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Ile Val Ala Val Val Ile 
                405                 410                 415     


Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
            420                 425                 430         


Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
        435                 440                 445             


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
    450                 455                 460                 


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
465                 470                 475                 480 


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
                485                 490                 495     


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
            500                 505                 


<210>  54
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor


<220>
<221>  SIGNAL
<222>  (1)..(18)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(275)
<223>  TK! ScFv

<220>
<221>  MISC_FEATURE
<222>  (276)..(290)
<223>  GS linker

<220>
<221>  MISC_FEATURE
<222>  (291)..(519)
<223>  IgG4 long hinge

<220>
<221>  MISC_FEATURE
<222>  (520)..(541)
<223>  FCGR2A transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (542)..(619)
<223>  FCGR2A cytosolic domain

<400>  54

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Phe Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Met Ala Val Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr 
                165                 170                 175     


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn 
        195                 200                 205             


Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr 
    210                 215                 220                 


Thr Asp Thr Ser Phe Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Gly Tyr Gly His 
                245                 250                 255     


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270         


Val Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    290                 295                 300                 


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
305                 310                 315                 320 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                325                 330                 335     


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
            340                 345                 350         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln 
        355                 360                 365             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    370                 375                 380                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
385                 390                 395                 400 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                405                 410                 415     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
            420                 425                 430         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        435                 440                 445             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    450                 455                 460                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
465                 470                 475                 480 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
                485                 490                 495     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            500                 505                 510         


Ser Leu Ser Leu Gly Lys Ile Ile Ile Val Ala Val Val Ile Ala Thr 
        515                 520                 525             


Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg 
    530                 535                 540                 


Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala Gln 
545                 550                 555                 560 


Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln Leu 
                565                 570                 575     


Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met Thr 
            580                 585                 590         


Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu Thr 
        595                 600                 605             


Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
    610                 615                 


