                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
 
<120>  TRANSGENIC EUKARYOTIC ORGANISMS AND METHODS FOR GENDER SELECTION

<130>  2625571

<150>  US 62/613,531
<151>  2018-01-04

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA1 for mouse Atp5b

<400>  1
cactgccacc gggcgaatcg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA2 for mouse cdc20

<400>  2
cagacctgaa tcttgtagat                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA3 for mouse caspase 8

<400>  3
tgcagagatg agcctcaaaa                                                   20


<210>  4
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA core for mouse

<400>  4
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgc                                                       76


<210>  5
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U6 promoter

<400>  5
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacacc                                                              249


<210>  6
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Knocking in (KI) sequence

<400>  6
gcggccgcac gcgtgagggc ctatttccca tgattccttc atatttgcat atacgataca       60

aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata ttagtacaaa      120

atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa ttatgtttta      180

aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg gctttatata      240

tcttgtggaa aggacgaaac acccactgcc accgggcgaa tcggttttag agctagaaat      300

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      360

tttttggatc cgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg      420

ctgttagaga gataattgga attaatttga ctgtaaacac aaagatatta gtacaaaata      480

cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa      540

tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct      600

tgtggaaagg acgaaacacc cagacctgaa tcttgtagat gttttagagc tagaaatagc      660

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt      720

tttctagaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      780

gttagagaga taattggaat taatttgact gtaaacacaa agatattagt acaaaatacg      840

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      900

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      960

tggaaaggac gaaacacctg cagagatgag cctcaaaagt tttagagcta gaaatagcaa     1020

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt     1080

ggtaccaggt cttgaaagga gtgggaattg gctccggtgc ccgtcagt                  1128


<210>  7
<211>  5270
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  mouse Uty gene 

Accession number: NM_009484.3)

<400>  7
attggaaagc ctggctttag ggagaggtta tggacgttac gtgcggttca cactgacggt       60

attataacaa ctttatgcgg atgctagcga agtttgatat tctaagaact tcgcttaggt      120

tctgcaacaa tgagttcttc ttgcgttcac catctgcgtg gtaatgtgac cagatagcct      180

ctgccgcttt ctcctttgcc agtttccatg aaatcttacg gattatctct cactactgct      240

gccctaggta atgaggaaaa gaaaatggcg gcggaaaagg ctagaggcga gggcgaagag      300

gggtccttca gtctcacagt cgaagagaag aaggcgcttt gtggattaga tagcagcttc      360

ttcgggttct tgacccgatg caaagatggc gccaagatga agacgctgtt gaacaaggca      420

attcacttct atgagtcttt aatagtaaaa gctgaaggaa aagtggaatc agatttcttt      480

tgtcaattag gtcacttcaa tctcttactg gaagattatt caaaagcatt gtcatcttac      540

cagagatact acagtttaca gactgactac tggaagaatg ctgccttttt atatggtctt      600

ggtttggtct atttctacta caatgcattt cagtgggcaa ttagagcttt tcaggaagtc      660

ctttatgttg accctaattt ttgcagagcc aaagaaatcc atttacgact tggttttatg      720

ttcaaaatga atacagatta tgaatctagt ttaaagcatt ttcagctggc cctgatcgac      780

tgtaatgtct gtactttgtc cagtgtcgaa attcagtttc atattgctca cttatatgaa      840

acccagagga aataccattc tgcaaaggca gcctatgaac aacttttaca gattgaaagc      900

ttgccatcac aagtcaaagc aactgtattg caacagttag gttggatgca ccataatatg      960

gatctaattg gagacaatac caccaaagag agatatgcta ttcagtatct ccaaaagtca     1020

ttggaggaag atcctaattc tggtcaatct tggtatttcc ttggaaggtg ttactcatgt     1080

attgggaagg ttcaggatgc ctttgtatct tacaggcaat ccattgataa atcagaagca     1140

agtgcagaca catggtgttc aataggtgtg ctgtatcaac agcaaaatca acctatggat     1200

gccttgcaag cctatatatg tgctgtacag ttggatcatg gacatgcagc agcctggatg     1260

gacttaggta ttctttatga atcttgcaac caaccccagg atgccattaa atgctactta     1320

aatgcagctc ggagcaaatc ttgtaataac acctctgcac ttacatcaag aattaagttt     1380

ttacaggctc agttgtgtaa ccttccacaa agtagtctac agaataaaac taaattactt     1440

cctagtattg aggaggcatg gagcctacca atacccgcag agcttacctc caggcagggt     1500

gccatgaaca cagcacagca gagtgtttct gatacctgga atagtgtcca gacagcttca     1560

catcattcag tacagcagaa agtttataca cagtgcttca cagcacagaa attacagagt     1620

tttggtaaag atcaacaacc tccatttcaa actgggtcca cacgatatct ccaagcagct     1680

agcactaatg atcagaatca gaatggaaat catactctgc ctcagaattc aaaaggggat     1740

gctcaaaatc acttcttacg tattcctacc tcagaagaac aaaagatcat taactttacc     1800

aaagagagca aggattcaag aagtaaatcc ttgacttcta aaacaagtag gaaagataga     1860

gacacatcta atatctgtgt taatgcaaag aagcattcta atcatattta tcagatctca     1920

tcagttccga tttccagcct taataataaa gaatctgtgt caccagattt aataattgta     1980

gacaatcctc agctttctgt cttagttgga gaaactatcg acaatgtgga ccatgacatt     2040

ggaacttgtg acaaagtcaa taatgttcat ctagccattc acaaaaagcc tgataatctt     2100

tctgcttctt caccctcttc agccatttcc acagaaacac tttctctaaa gctcactgaa     2160

cagacacaca ttgttaccag ctttatcagt cctcacagtg gattacacac aattaatgga     2220

gaagggcatg agaacttaga gagttctgcc agtgttaatg ttggcctcag acctagatct     2280

caaatcatac catcaatgtc tgtgtccata tactccagtt caacagaagt tctgaaagcg     2340

tgcaggagtc taggtaaaaa tggtttgtct aatggtcata ttctcttgga tatatgccca     2400

cctccaagac caccaacttc gccatatcct cctttaccaa aggagaagtt gaatccaccc     2460

actcctagta tttatttgga aaataagcga gatgcctttt ttcctccatt acatcaattt     2520

tgcatcaatc caaaaaaccc tgttacagta attcgcggtc ttgctggagc tcttaagtta     2580

gatcttggac ttttctctac caaaactttg gtagaggcta acaatgaaca tatcgtagaa     2640

gtgaggaccc aattgttaca gccagcagat gaaaactggg atccctctgg aacaaagaaa     2700

atctggcgat atgaaaataa aagttctcat actacaattg ctaaatatgc acagtaccag     2760

gcctgctcct tccaggaatc attgagagaa gaaaatgaaa gaagaacaca agttaaagac     2820

tattcagata atgaatcaac atgttcagat aattctggaa ggagacagaa agcacccttt     2880

aaaaccataa aatgtgggat taacattgat ctgtctgata acaaaaagtg gaagttgcag     2940

ttacatgagc tgacaaagct tcctgctttt gtacgtgttg tatcagcagg gaatcttctc     3000

agtcatgttg gctatactat attggggatg aattcagttc aactatgtat gaaagttcca     3060

gggagtagaa taccaggtca ccaagaaaat aacaatttct gttctgttaa cataaatatt     3120

ggtccaggtg attgtgaatg gtttgttgta cctgaagatt attggggtgt tctgaatgac     3180

ttctgtgaaa aaaataattt gaatttcctg atgagttctt ggtggccgaa ccttgaagat     3240

ctttatgaag caaatgttcc tgtttatagg tttattcaac gacctggtga tttggtttgg     3300

ataaatgcag gcactgttca ctgggttcag gctattgggt ggtgtaacaa catcacctgg     3360

aatgttggtc cactcacagc cttccaatat aaattggcag ttgaacgata tgaatggaat     3420

aaattgcaaa gtgtcaagtc agtagtaccc atggttcatc tttcatggaa tatggcacga     3480

aatatcaaag tctcagatcc aaagcttttt gaaatgatta aatattgtct cctcaagatt     3540

ctaaagcatt gtcagacttt gagagaagct cttgttgcag cagggaaaga ggttttgtgg     3600

catgggagga taaatgatga accagctcct tactgtagca tctgtgaggt ggaagttttt     3660

aatttacttt ttgtcactaa tgaaagcaat tctcaaaaga catatatagt acattgtcag     3720

aactgtgcac gaaaaacaag tggaaatttg gaaaattttg tagtgctaga acaatacaaa     3780

atggaggacc tgattcaagt ctatgaccaa tttacattag ctccttcgtt atcttctgca     3840

tcttaatatt gttccagaaa tactgaggcg tttgttcttc ttgaaatata ctacttattt     3900

tcttgttatt ctcataagac tgctatctca aagctaaatt tatgcaacct ttcaagagta     3960

gagaatcagg agactaaaca gagcattact tctattccaa gatttacaaa gttgacccaa     4020

atgtatttca taattaaaag ttaatagtaa tagtcacatg atttgtatat atctgccaga     4080

aataacattt tgacacaaac aaatacctgg aaaacaactt tttatatctc catttcctgg     4140

atgacagatt tctttatgct tgtaagttac cccaaatttt ttgtttagaa tcaaatagta     4200

tcttatttgg ctacttcttt ttaagataac taacaaattg aaaaaaaatt ttttctttta     4260

ccaatttttt gctaaagtca aaataatatg aaaaaggttt atattgctct gtcactattg     4320

ttttgaagtc ttgatttcat gtgattacaa aataaaaata ttaacagact ggtaaaaaga     4380

ttataggttg catataaata atttcaaagt gatggttttt tgttttgttt tgaatcttga     4440

cacaaactca aactattcat aaatacatat atatatgtgt atatatgtat gtatacatat     4500

atgtacatat atatatatat acacatacat acatatatac atatatatgt atattgctgg     4560

aaaatccttg tgaattgaat gttatttttt tctagattta cttgccatta aatactaagg     4620

agttgtataa ttttaaatgc cacaattaat ttttatatgt gtaaataaag ctacttagta     4680

ttgtacataa actcttatta aaattattta gtgtataaag aatttttcaa tgtttgagtt     4740

ttgaagatta tatagttcca atctttgttc cttttcaaag ttaatgaata tatgtattta     4800

agtctgccaa cacatgtatg tatgtagaga tctcagtatt tcactcaaca agaaaatcac     4860

aatttttcaa ttttttatgg ctgaaagttt ttgaaggtat ttgcttacaa aataggtatg     4920

cttattttta aagaccatca gtgtctttta gtctgattag gttacacctt atgaaatgac     4980

aagtagttgc tgtcagaaat attttttaag ggtagaaaat aaaggtaaat taagattttt     5040

ttataagaaa catagatttg acaagtgctt atcatttaga gttttgcttt aatggaaaag     5100

ttcattgcaa tgatgatctc tattttagag tttaatattc ctaggaactt ttaaaacaga     5160

taattttgaa attccatgta ttcctgcttg ttcaatctgg tgtgtgttgg gagacttacg     5220

cattaaaatt tattattagt aaatcttaaa aaaaaaaaaa aaaaaaaaaa                5270


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA1 for chicken Caspase 8

<400>  8
atacaaagac tgcactgcag                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA2 for chicken Atp5b

<400>  9
ctcgggcccc gttaaagcgg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA3 for chickenCdc20

<400>  10
gatggtcgct acctggccag                                                   20


<210>  11
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes M1 GAS


<220>
<221>  misc_feature
<223>  Cas9  

Accession number: AAK33936.1

<400>  11
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210>  12
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes M1 GAS


<220>
<221>  MISC_FEATURE
<223>  Cas9  protein 

Accession number: AAK33936.1

<400>  12

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  13
<211>  7119
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  mouse gene Atp5b (ATP synthase, H+ transporting mitochondrial F1 
       complex, beta subunit)

<400>  13
gcaggaccgg cggagaggac cgcttcggcg ctcagtctcc acccggattc cgccatgttg       60

agtcttgtgg ggcgtgtggc ctcggcctcg gcctccgggg ccttgcgggg actcagccct      120

tcggcggctc tgccacaggc gcagcttcta ctgcgagctg ctcccgccgg ggttcatcct      180

ggtaagcgcc ttcctggagg agctagttcg gttcttctcc ccgtgacctt gagcttgggc      240

ctatcggatc cgttctccat aaggattccc gggcagcgga ctactgtcca gccgaggagt      300

gcaaggacag tcgcccgtgg gagcgttgat ataaccagca gcgtcccatt ttgtgaggct      360

agagtggccg gcagctgcct cgaccttgag gttttgaggg ggataccaaa ctcgagaata      420

atggcggttc tgtgcacgag gtcgggaaaa cagtgcgggt gggttcccga ttgcagcgtg      480

cccttctcca tgcctcctcc tatcttgcag gagacttagt ctgggctcag ctaaccttcc      540

ctcgggggat aaatctggga ttcgggtgac cttaagctgt cctaacacca acgccttcca      600

ataccttttt gtctgctagc cagagactat gcggcgcagg cgtctgcggc cccgaaggca      660

ggcactgcca ccgggcgaat cgtggcagtc atcggcgctg tggtggacgt ccagttcgat      720

gagggattac cacccatcct aaatgccctg gaagtgcaag gcagggacag cagactggtt      780

ttggaggtgg cccagcattt gggtaagtag gacgttttag aggtgggaaa gagcttgtta      840

ggcttaaata acacgagatc gtgccatctc cattctgtga tgactttacc aaatgacttt      900

cgttcttctg agtttgctga agccacactc aggtgctgag aggggaggcc tgtttgcttt      960

tgatcaccct tcattacata ctgttaggtt ttggtgctta taacgtgtta atgctgattg     1020

acaggggaga gcacggtcag aactattgct atggatggca ctgaaggctt ggttagaggc     1080

cagaaagtac tggattcagg ggcaccaatc aaaattcctg ttggtcctga gaccttgggc     1140

agaatcatga atgtcattgg agaacctatt gatgagagag gtcctatcaa aaccaaacag     1200

taagtttctc tcactgcatt tgtgaacatg ggaacctttt cttgcagttg tacacatggg     1260

gtaataactg gtagtaaagc aacattttcc tacagtacta cttccatttc tgttgtattc     1320

agttattgaa aatgaagata cagaagtttg gattgttgaa aacttgctac atagaacccc     1380

ctgttacttt ttttaaagct gtgttacatt atggattctc taaaatttac aggtttttat     1440

tttcttattg ttatataaag aaactttgtt atattaagtt cagtaaaagg aaaatatcaa     1500

aaaagaggat tatttgttct tgagactttt tttttttggt ttttcgagac agggtttctc     1560

tgtatagccc tggctgtcct ggagctcact ctgtagacca ggctggcctc gaactcagaa     1620

atctgcccgc ctctgcctcc caagtgctgg gatcaaaggc gtgcgccacc acgcccggcg     1680

agacaatatt ttttattgca gagagatgat gttctgtgac agcttaactt gaacaagatt     1740

agacttgact gtttgtggtg gccagtggct tttgagcatg gtgcctggtt ctgacccttt     1800

cctccctgaa ccttacagat ttgctcctat tcatgctgag gctcctgagt tcatagagat     1860

gagtgttgag caggagattc tggtgactgg gataaaggtt gtggatctgc tggccccata     1920

cgccaagggt gggaaaatcg gtacgttggt ttttggtccg tgttttccaa atacagtaaa     1980

gcatggagac ccttttttct tttgagagtg cttgagcctt cagtgatgat tagcttctga     2040

ctttcgttct tctgaatttg ctgaagccag atgccgttcc tgagaagggg aaaatggaca     2100

gaactgaaca tttttgaagg ctgtttaatt tgggaatgca gagatctgaa atatttcttc     2160

ttaaactagg actctttgga ggtgctggcg ttggaaagac agtactgatc atggagctaa     2220

tcaacaatgt cgccaaagcc catggtggtt actctgtatt tgctggtgtt ggtgagagga     2280

cccgtgaggg caatgattta taccatgaaa tgattgaatc tggtgttatc aatctaaaag     2340

atgccacttc caaggtgagc tccattcaga aaactaatgt gttatgtttg atgtgatgag     2400

ccccgggttc tgtaaacaaa atagttgtct tcccaccacc attttccaga ataccagtgt     2460

acacttctct ggtgtgagat atttctagac tttttgatga gtaagtaatc caatttgaaa     2520

gctgatttaa aaggtgtaga atggaagcca ctcacatatc tcagtcttac ttttagttta     2580

gaaattattt ccagtgttct caatttcatg aaggttccaa acagaaacat tggcatccag     2640

tggaagatcc cattagtggt gtctctctct ctcttcccct ctcttctctc tgattgggaa     2700

tcttggattt ctctgtggct tccttactac tctgctgtct tttctgactt gtgtatgttt     2760

tacaggtagc gttggtatat ggacagatga acgaaccacc tggcgctcga gcccgggtag     2820

ctctgactgg tttgaccgtt gctgaatact tcagagacca ggagggccaa gatgtcctgc     2880

tgtttattga caacatcttc cgctttaccc aggctggctc agaggtaggg gggaagcctc     2940

gaggcctggt ttgttgagcc agttgggcat attagaagaa agatgtagac acctaagacc     3000

attattcttt acttctgtct tttaggtgtc tgccttattg ggcagaatcc cttctgctgt     3060

aggctaccag cccaccctag ccaccgacat gggcacaatg caggaaagga tcaccaccac     3120

caagaaggga tcgatcacct cggtgcaggt aatgaaaaaa accaacctag ggagataata     3180

acaccatatt atacttgggg ctagagagat aattcacagt taagaatgct tttggctctt     3240

ccggttgccc agtgtccatc aggtggctta ccatctgtaa ctccagctta ggagacatgg     3300

cgccctcttt tggcttccat gggtacctgc atatacagta aacatggtct ggggcgcgga     3360

gatgtacaaa aatcatgtgc taggtgaaat ggcacttacc tttaatccca acacttagaa     3420

ggcaggggca ggtggatctc tgagattgag gccaacctgc tctatgtaga gttccaggac     3480

agacagtgtt gcttcttgag gtcctgagtt tgattcccag caactacatg gtggctcaaa     3540

gccatctgtt atgggatctt ctggcatgaa ggtatatata cagattgagc actcatgtat     3600

aaaataaaaa ataaatttaa aaagattatg tatttgtatg ctagattgta aaggttaagt     3660

tagaaacaaa tgctcattag ctgggcgtgg tattacatac atatacctgg gatcctagca     3720

catgggaaac aggcagaagg atcaggaact caatgctatt tccacctaca tagtgaattc     3780

ctgcctaact tcactatatg acactgtctc acaccagaaa ataggacatt tttttttttt     3840

ttaaagattt atttattgat tatatgtaag tacactgtag ctgtcttcag acactcaaga     3900

gggagtcaga tcttgttacg gatggttgtg agccaccatg tggttgctgg gatttgaact     3960

cctgaccttt ggaagagcag tcgggtgctc ttacccactg agccatctca ccagccccca     4020

ataggacatt tttttaagta attctaaggt actggggctg aagagatggc tcagtagtta     4080

aaagtacttt ctgtaggcag gtggtggtag cccagaggaa gcagaggccg gcagatctcc     4140

aagtgtgagg tcagagtggt ctaggaccaa ttccaagata accagtgcta catagagaaa     4200

ccctgtcttt ttttttttaa agatttattt tattattata tctaagtaca ctgtagctgt     4260

cttcagacac accagaagag ggcatcaggt cttattaagg atggttgtga gccaccatgt     4320

ggttgctggg atttgaactc atgacctttg gaagagcagt cagtgctctt accctctgag     4380

ccatctctcc agcccccgaa accctgtctt aaagaaagaa aaagaaaaag aaaaaaagcc     4440

atactttttg ggattgtatt cccagttgga gaggatcagt ccgactcctc gggtacattc     4500

tgcaggctca gtcgtgcata tgatacacaa tgaaaatatt gttgtatggt ttttgacatt     4560

agatctactt gtgtagcttc agctggcctg gtactcactt tctgttcagc tctgtttggc     4620

agctcatagc agtcctcctg cctcagtgtc ctaagagttg ggattataga caggagctgc     4680

tacatctagc tttcattgtt atcttgattg tgtgctgtgt attccgaggc acataataag     4740

caagcaacaa gcaacacata agcaagataa tgatgataac agaccttacc atgcaccctc     4800

gtggtcatat ttacttagta ttgcagtgca ggaacatctt ttaagagcac aacataaata     4860

aaagttggta ccatcacaat aaagtgttgg catagtatgc agacccagat aaagggagtc     4920

catagcttaa tccagtccca gagatgccaa gaaagaaaaa aaaagacctt gattttaaga     4980

gggaaatgaa aagagcaggc ttaagcagga gtggggttac tgctgatctc ctgggttctt     5040

gactctaggc tatctatgtg cctgctgatg acctgactga ccctgcccct gcaaccacct     5100

ttgcccattt ggatgctacc actgtgttgt cccgggctat tgctgagttg ggcatctatc     5160

cagctgtgga tccactggac tccacctctc gaattatgga tcccaacatt gttggcaatg     5220

agcattatga cgtcgcccga ggagtgcaga aaatcctgca ggtgagtatc tttatcctca     5280

gagtcaatgg ccatcaaatt gtaaggaatt tgagacctct ataaggacta gatttttttt     5340

tccccctagt catttgtgtg aacaaggaaa gttgagaatg gattgatact gctgatgagg     5400

tgtccccagt ttcagggtac tctacttcac ccttagaatc cagttgtcag actggcagta     5460

gtggtgcaca tctttaatcc cagcactcag gaggcagagg ccagcctggt ctacaaggat     5520

agccaaggct acacaaagaa actctttctc aaaaaaataa tcagttgttt tctaacctag     5580

ttgaataggc agaataagac actaaccttg gttgatggct tcctggacct tctgaaagtg     5640

taggcactta actctgtcct tcctttcatc ttgcttgctt ttaggactac aaatctctcc     5700

aggacatcat tgccatcttg ggtatggatg aactttctga ggaagataaa ttgactgtgt     5760

cccgggcaag aaagatacag cgcttcttgt ctcagccatt ccaagttgct gaggtcttca     5820

cgggtcacat ggggaagctg gtgcccttga aggagaccat taaaggattc cagcagattt     5880

tagcaggtga ggttttttct ttttatcaag cctagccata aaagtgagag aaaacaagcc     5940

tatcttctca ttctaacatg atcaaatgaa atgatacata cctttctttt ctttcttaaa     6000

gatctattat gtgtatgtac actgtagttt tcttcagaca ctccagagac agcgtcagat     6060

cccattacag atggttgtga gccaccatgt ggttgctggg aattgaactc aggacctttg     6120

gaagaacagt ctatgctctt aacctctgag ccatctctag cccccttgtc tatacttttc     6180

ttaaagtata ccattaaagg ccattaccct gccttccatt aactgtccca tgtcactgag     6240

ttgaaagtga gaattttaac tcaggtgctc cagattacgg gtttttaagt gcttgtgtgt     6300

ctgagtgttg tatgtgatgt gagtacacga tcccatgagg agttagatcc tcccagaaca     6360

gtcagtggag gttaggagtg gtgtctggtc actggaatta gaggtgataa agcagtagtc     6420

agtgttaaac caccactcaa gccccaaaca tattcttgat ctactacatc ttgtcttaaa     6480

ttacacactt tacactttaa aaacaattat acttggaagg gggtggatat ggtgcacacc     6540

tttagtgctg ggactcctaa atagatctag gggcttgagt tccaggtcag ccaggaacac     6600

acccccaccc cccaaaagta aatttcacgt ggaagttgaa aagtttcctt gcatgataag     6660

gtttcacagt gggctcaagt ggtgaggtgt acatgctgca ggaagctgat ataactcagc     6720

ttcttactgt gttttcccct atgtaggtga atatgaccat ctcccagaac aagccttcta     6780

catggtggga cccattgaag aagccgtggc aaaggctgat aagctggcag aagagcacgg     6840

gtcgtgaggg actccagcca aaggcagcac tgcaactgat ctctccatat caagcgagag     6900

ctcaggtttc cttccatgca ggccacacaa gagccttgat tgaagatgtg atgttctctc     6960

tgaagagtat ttaaagtttt caataaagta tatacccctc atttatgtct gtttatgttg     7020

cttctgaaac agcttataat tgagctcaca gtggtgggcc acatttagga aattgttaga     7080

aacaggatta ttattaaaaa gatcaattta ttaatgaga                            7119


<210>  14
<211>  4452
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  mouse gene Cdc20 (cell division cycle 20)

<400>  14
gccaatgaac gctagcagcg gagagtttaa gaacaacagt ccggcgtgtc cttagcttgt       60

ctggaaaaga acgcgttcgg caggcgcact gacgcgctgc gaggagctgg gggtttgtgt      120

tcgggagagc tgagtacgga gagggaccgg gctgctgcga gctgtggcag gcggagccca      180

ggagcccggc gaggatcgcg cttggtcgcc tttcgccccg gtagcggtgc catggcgcag      240

ttcgtgttcg agagcgattt gcactcactg cttcaactgg acgcacccat ccccaatgcc      300

ccggttgcgc gctggcagcg caaagcaaag gaagccacag gcccagcccc ctcgcccatg      360

cgggccgcca acagatcaca cagcgccggg cggaccccgg gccgaactcc tggtgagtgg      420

gtggagggag ctggaatcgc tgagagtccg tcttcatgct ccctccggga gcctcgtcag      480

gctgtctgac ttctctctcc ctgcccccag gcaaatctag ttccaaggtt cagaccaccc      540

ctagcaaacc tggaggtgac cgctttatcc cccaacgcag tgcttctcaa atggaggtgg      600

ccagcttcct cttaagcaag gaaaaccagc cggaagacag ggggacgccc accaaaaagg      660

tatgattcca caggggtcat gagacttgag gtgtctgtcc cctggctgat accggtcttc      720

ctcccctcac ttgccgtgta tttcaggagc atcagaaagc ctggtctctc aacctgaacg      780

gttttgatgt ggaggaagcc aagatcctca ggctcagcgg caaacctcag aatgccccag      840

aaggtaagga gtgagtgaca tcatcgaggc tggtgtcagt ccttcctaag gggagacatg      900

tggctgcttt tccacatgtg gatgggtatc agtttccaag tctagaccca ctctcttgcc      960

acaggctacc agaacagact gaaagtactg tacagtcaga aagccacgcc tggctccagc     1020

aggaagactt gcagatacat cccttctctg ccagacagga tccttgatgc ccccgaaatc     1080

cggaatgact actgtgagtg cactgttgtc tttgcggatg gagaaagatg gcctaggaat     1140

ggaccagtcc aacaaaggac ctcatgtttt cttccttccc ctggcagacc tgaatcttgt     1200

agattggagc tctggaaatg tattggctgt ggcactggac aacagtgtgt acttatggaa     1260

cgctggttct ggtgacatcc tgcagttgtt gcaaatggag cagcctggag actacatatc     1320

ctcggtggcc tggatcaagg agggcaacta cctagctgta ggcaccagca atgctgaggt     1380

ccaggtgagc ctggttgcct gtattgtggc tctgtggtca ctgggctcag gggggagctt     1440

gcccacctta catctgtgac cctgtggtca ttcctctgca gctctgggat gtgcagcagc     1500

agaaacgact tcgaaacatg accagtcact ccgctcgagt aagctccctc agttggaaca     1560

gctatatcct atccaggtcg gtgtttttcc cagtctatag cagaaccttt ccggtttctg     1620

ccatccggaa ctaaatctct tcttctctca gtggttcacg gtctggccac atccaccacc     1680

atgatgttcg ggtagcagaa caccatgtgg ccacactgag tggccatagc caggaagtat     1740

gtgggcttcg ctgggcccca gatggacgac atctggcaag tggtggcaat gataacattg     1800

tcaacgtgtg gcctagtggt cctggagaaa gtggatgggc tcccctgcaa acattcactc     1860

aacatcaagg cgctgtcaag gtgagaaagc atttgagctg aggtctttac agacactcag     1920

ctataaacga gggactacta agaggagagg acaaggcggg gttgagttta attgtgacac     1980

ttagagttga gagatggttt tgtccactga gtattcataa tagatgatga ctactgtgcc     2040

cagagagctg ggtgccttcc agcatcgtca cgattattga agcagctcct gtcttggagt     2100

tgtttgaaaa ttgttatcac ctctgattgg ctaataaaga gctgatcaac ctgtagctgg     2160

ggaggagagt ttaagatggg tgggaaaaga ggtgaggtca ccaggaggga gtctccagga     2220

gatggtggag gaggagcagc cagggcgaga cggagatgtc aggttacagg gcaggtgctg     2280

ggtgttaggc atcagagctg ggttagaata gatgagaacc ctgcccagct atagtgcaag     2340

aagctcttta atacatattc caggtttctg tgccatttca agggaaagga gggcatggaa     2400

aagctcagtt cttttacacg tagggctgct tctgcctctc tgttgacctg acccagcctt     2460

tatccattcc acccaggctg tggcatggtg tccctggcag tccaatatcc tggcaacagg     2520

aggaggaacc agtgaccggc acattcgcat ttggaacgtc tgctcagggg cctgtctgag     2580

tgctgtggat gtgcattccc aggtagtttt gttgtgattg ctactggtgg tgattcatgg     2640

tttaacctat cccaggcaga ggtgtgttcc tctatgtgac atttctgaac agccacttct     2700

actccaactc tctacctgat catttctaaa tttctgactc agccctcact ggcattccca     2760

tttcctagtt tggcttctct ccaaccctag gtcctcaaga atcctcctcc tccgtatgtc     2820

ctaattaagc ttgtcagttc accttgcctt cctgaaatgt actgtgttcc acttgtactg     2880

ttttagatgc agaacctgct tagaaatctg aaaagccacc tagtctttca tccttctcag     2940

gatatttcag tgttagcttg aaataccatt cacatccgtc ccttcctcag cactctcatt     3000

cattcattca ctcattcatt cattcattca ttcattgagg cagggtcttg tgagacagag     3060

tcttgccttt gctggcctca gtcctgcttt taacatccca agtgttgaga ttaccagcat     3120

gtaactccat gcccaggctc ccacacattt tctctctctt ccagttccct ttatacaatc     3180

cgagtggtat cttactgtcc ttaaacctgt gatgactccc acaacctaca gcataagatc     3240

caaatacatt agacccgggc tgtgttgtgc ctttaatccc agcacttggg aggcagaggc     3300

aggcggattt ctgagttcga ggccagcctg gtctacaaag tgagttccag gacagccagg     3360

gctatacaga aaaagaaacc ctgtatcgga aaaaaaaaca aaaaaccaaa tacattagaa     3420

catttgaggc tcttgctgct gatatgcctt gctgtaaata ctccagtttt ccctatctgc     3480

tcccctcact cggccttcac tgcaggtgtg ggctctgaag gcagatggtt gaagttgcca     3540

agggagtcgc ttatgggatg actttgggta acatgaaact tcccttctgg tggattcatc     3600

ttcatcacca tagatgtgtg tctgggggct tcagtgagga ctgtgaccat taagttaaat     3660

ctgtagtgcc tgacagggtg tctaatacta gaatggactg actcggttct gagtaaccct     3720

gcctgactca tgtccgtgat gaccttctcc acaggtgtgc tccatcctct ggtctcccca     3780

ctataaggag ctgatctcag gtcacggctt tgcccagaac cagctggtta tttggaagta     3840

tccaaccatg gccaaggtgg ctgagctcaa aggtaggtgg caataggaag ccaggcagaa     3900

aggccacata gtgtatgttt ccatccatat gaaatattga gaataaacag actgatatga     3960

cttgcctggg gatttggcaa gggtggtggg agggtatgat tgcacgagaa tgggtaaatg     4020

cagagttaac aggcttagat ttagaatgtc gtggtactgg ttataacaat gtacaaccta     4080

accttgtaaa tacagtaaca ccactgaatt ataaaagggt gagtgtatgg cattcaaatt     4140

gcatttcaag gtgactgtca aagttagagg gaggcctgtg tgtatactca aatgcactgc     4200

tctcgcccta ggacacacag cacgggtcct gggtcttaca atgagtccag atggggccac     4260

agtggcatca gcagcagctg atgagactct acggttgtgg cgctgctttg agatggaccc     4320

tgcccttcgg cgtgagcggg aaaaagccag tgtagctaaa agtagcctca tccaccaagg     4380

catccgttga acaaacgcat ttcctttctt gtttttattt tattttttct aataaagttc     4440

gtatcttcct ta                                                         4452


<210>  15
<211>  52130
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  mouse gene Casp8 (caspase 8)

<400>  15
ggaataagga agtgtcctcc agaactggcg ggagctctta aggcgggcag aaagcgaagc       60

agcctatggc ctctagggct ggcaccagga tgccacctct aatgattaac tcaaacgcct      120

ctaaacattc ggaggcattt ctgtccccta tgccctagtt ctctcagttg tctttcattc      180

tgacttcggt gcttaaaagt ccagcttctc ggaatcggta gcaaacctct gtgagccggc      240

gtggaacagg aagtgagtac agttctgggg agcgccggcc cgggctggag gctcggaaag      300

cccaagccag cggaggcctc gcccgagctg gagttgtgac cggcgcggca ggtactcggc      360

cacaggtgag tgctgcagag cagtcgggtt cctttcccac cagcgggccg agatcccacc      420

ggtgggtgtc gatctcgcgt ggcgctcccc gaaatgcagc catcggggtg ccgtcgccgc      480

ctctccagaa aactttattg gacttcttag gcttactttc tttgtagttt ggctcaggac      540

ctggagctga gttaatcctc cggggagtcc tctagcttga gctgcgtttc ctccggcgat      600

tttcgtgctc ttcccaactc agacgtccat caactctaat cccaaattct ctcttccttt      660

ctccttctcc tccaacatct cccctccctt tttctctccc tcttcttctc tttgccttct      720

cctctccctc cctctcctct tcctctctcc ctccctccct ctgtccctct ttggtttcat      780

gatttcctgc agaagctcag gcttcttgaa cttacgacct tgcttccacc tcctgagtgc      840

tggcagtaca gggggtgggg ggtcgtaggg cactagctct gcacttaaaa caccaacccc      900

ccaccccctc accccaaccc ccacagagag gggatgagag aggagggagg gagggggcta      960

caggtgacct gaggccggta attcctctac gtgctaagca gttgtaaggg tgactggctt     1020

gttaagtacc tgtaaggaat tatcatacag tcatatttct gtttcttctt tctttctttc     1080

tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt tctctctctc     1140

tctctctctc tctctctctc tctctttctt tctctttctt tctttccttc cttccttcct     1200

ttcttttctt ttcttttctt ttcttttctt ttcttttttc tttctttttt ttctttttct     1260

tttttgtctt tttaaaggga gtcctctaag tgccttctgc ttggctaggt ctcagtttca     1320

ttctttaaaa aattatttat ttctatttta atttcatgag tatgagtatt ttgcctgcat     1380

gtatgtatgt gcacctggta ctgggcgggg gggggggggg tggcggcaca gattccttga     1440

actggattta cagacagttt cagccattat atgggtgctg gaaactgaac ccaggtggtc     1500

tgcaagagca ttgagtgctc ttaaactcct gagttgtctc atcgacaaat ctttcttttt     1560

ttaaataaat atggcattga ttgaattagc atgaggacga ttagtgctcc cgtttcttac     1620

aaacctattt aaagaagact caagaactcg tatgtggaca cagaggagtt gctggtcatg     1680

gctgtgtgtc tcccatgtct ctttcccagg agggagaaag gtgaccccat agcaggccat     1740

ttagctgtta tttgattttg cccagtaatt tctgtttgtg ggtaggttca ctccaggaac     1800

taatatgatt tctccagcag cctgcatagc ctgaccacct caccctatca ggttgctctt     1860

ttttcttttt cttttctttt ctttctttct ttttttttaa tcttccaact taaaagaaat     1920

tctaataaga aagtgggcat cttcttgctt tatttgacat tcctcggatt tactgaccca     1980

tgtgatgtgt catcctatgc tctcatgggc ttagtgccta taggggagct ccatgtgttt     2040

tttccagcaa gaccacaccc ccattgcccc tgtacagagg ttcattgcct ctttacacag     2100

tatcttctca ttgatgattt tcaggctgtt gttatgtggt tcaagtatta ccatgagagc     2160

ttcagttgct gcactcacag gaagttcgtg gtctctgaca ggaaattctc agaaaacagt     2220

gagccagaac tggggtagag gttatagagg atgctgggaa aactatagta actcctggag     2280

tggactgggc cacagacagg atttgatttt gctgcttcca tggtgcccag gttcctgggc     2340

agaatcaaat gccagctaaa ggtcctggta cgatggtgtc acctttgccc agacatcgag     2400

ggtggacata tgcttttggg cgcctcattc agttccctca gctgtgaagt tggcgctctt     2460

tactctgaaa gtttacattc tattttaggt agcagaaaac acagtttcaa agtccttttc     2520

tttttcttct ctttaacacc agaaaatatt ttaactaatt cccagcaagg agcttatgtg     2580

tttgtacaca ggtttgctca cacaatgaag gacccagggt ttgcctcttt ggggagtttg     2640

ctgtaggaaa gccctgattt tgactttagg cttatttttt gtttgtttgt ttgtttggtt     2700

ggttggttgg ttggtttttt ttgttttttt gtttgtttgt ttgtttgttt tgttttgttt     2760

tgttctgttt tagctgtaag tagaaactat cgaactagga gcaaggagaa catccctgtg     2820

taacagtaag acttagctgt ggaagtcagc aaaccctcaa agcccaggca ggactctagg     2880

cccatcagag gtgaaacact tctggggcct atttttgcta gttaataaaa ttttagaaat     2940

taattctttt atttttttta agattctaaa agcaggtaga atgaaagttt ttcaggtata     3000

ttcatatgat ttttctaaat ttcattgata ttagttgtaa tgtcttcctt gttgcttcta     3060

actttgttaa tgtgggtttt ctctcttttg cttggtttag tttgtttgtt tgttgttttt     3120

aatcttttct tcatatcaac tctgcttctt taattctttg tgaaattttt tgttttgttt     3180

tggtttgttt cattaatttc tgccctgatc ttaattattt ttcccatatg tcttaatttt     3240

tctgttgcta tgaggaaaca ccatgaccaa ggcaactttt agaagaaagc atttaattgg     3300

gagcttgctt ccagtttcag aaggttagtt cattatcatc attgtggggc gcatggggac     3360

aggcaggcag gaaaagtgct ggctggacca gtagctgagc tcacctgatc cacaagttac     3420

aggccaatgg agagtgagaa actgggcctg gcatgggctt ttgaaacggt gaagcccacc     3480

cccagtgata tgtctttttc cagcaagacc acacctccta atccttctca aagagttcca     3540

gtaagggctg ttctcattca gaccaccaca gcatctgttg ctttggggtt tagcttgctc     3600

tcattttgcc acagtcttaa ggtgttttca ttgagttact aatttgaaac ctctctgact     3660

tttttcccat ttgtttagtg tgtgtgtgtg tgtttagcta tgtgcatgcc accgtgctct     3720

tgtttcaccc tgtgagttcc aggctttaga agcaagcacc tttatctgct gagccatctt     3780

gccagtccct ctcgaagttt gtgtgtcgaa ggtttctttt tattattatt tttaatcatt     3840

taaaattatg cgtatatggg tgtgtatatg catgtgagtg ccatgcccaa gaagccagaa     3900

gagagtgttg ggccccttgg agttggagtt acagatggtt atgagctgcc caatgctggg     3960

aattgaactc tggtcctctg taagtgcagc aagtgctctt aaccactgag ccacctctcc     4020

agtccctctc tctgctttgt aatgtaggtg cttatagcta taaatttgcc tcttagggca     4080

gctttcattg tatcccacag gttttagtgt gttgtgtttt cattttcaat tttgcctagg     4140

gatttttttt ttaatttcct tcttgacttc atcagtaaac tggtcatcat tcactagcgt     4200

gttatttact tagtgttaat tagtgtgtta atgagtttgt atattttttt aagcattctt     4260

ttgctgttaa tttctagctt tacttcacgg ttgtcagaca gagcgtgaga tgttctttcc     4320

actttcctgt atttgctaag gcttgctttg tgtcctctta cattatccga gagctctgag     4380

gaccaccaga agacacgcac tcggcagtgt ttgatggaaa ccttctgtag atcgctgtta     4440

actccatttg atctggtatc tcatgtaact cagatgattc tctacttaga gatgggaatg     4500

aagtggtgaa gttacccact tactgtgctg ggtcagttcg tgactttagc ctgagtagaa     4560

tttgttctat gtatacatca atgtttagaa gttcaatgtc ctcttgatgg attgttccct     4620

taatccatat gaagtaaact tctgtacctt ctgactagtt ttgggtagaa gtctctcttg     4680

tcaagtattt gaacaatgat gcttacttgt ctcctagatg cattccttgc gtccatgata     4740

ccgtaccctt ctaccccttc accttcaagg cagtgttcct ttatctttga tgtcaaaggg     4800

tttttttttt cccctcaatg acaataggtg gatcctgttt ccttgttttg tttttgtttt     4860

taaatgcaat ctgcagttcg tgacttttga ttgtgatccc aagaccacta atacccagaa     4920

ttacttttga aaggcattgc tcaagaagta agtccaacag ttgccaaatg agacctcatg     4980

aaactaaaaa gctctttgta tgtcgaagga actattaatt gggcaaagag acagcattca     5040

gaatgggagg gaaatctttg caaactatac atctgacaaa atattagtct agactatgca     5100

aagaactaaa aaagtaaaca gtaagaaatc aaacaatcca acaaatgaac aagtggctca     5160

caaaaattga actaaagatc cagggggttg gctgaggggc gaaggtgctg ggtcaccgag     5220

ctggacaacc tgagttctat cccagagcat acacgacaga cggatgagga tggacggacg     5280

gacgaggaca gactcccaaa ggctgtctct gacttccaca agtggcaaga atgcctctca     5340

ctctcggttg aataaataaa caaaaaaagt aattgattaa ataaatggta agaaaacaat     5400

gaaaacgttc tccgctccac tggccatcag agaagtgtga gttaaagacc tttgagtttg     5460

catctcatcc ctgtcagaat agcagtcatt aaaataacaa ataatggggc ctagtgagat     5520

ggctcagtgg gtaagagcac cctactgctc ttccaaaggt ccgaagttca aatcccagca     5580

accacatggt ggctcacaac catctgtaat gagatctgac tccctcttct ggagtgtttg     5640

aagacagcta cagtgtactt acatataata aaaataaaaa taaattaaaa aacaaataac     5700

atttattctg atggagttag gaattttgct gtatctcttt ggaatttatt tagctgcaag     5760

agagctaacg aaactgaatt tattagttag taattgcaat tcctgtgccc ccatactttg     5820

tagtcacatt tttaaaaaat tagatatttt ctttatttac atttcaagtg ctatcccgaa     5880

aattcctact ttaatgatga catagaaaag ccaaaaatta ctaaacacta atactccact     5940

aatactctag atggtaattg ttaaaattat catcttttat ttacctagtc acttgaaaac     6000

atgagtatct aaaacctggc agaagctatg ttatacaaca agaataaaaa taaagttata     6060

caatgaacaa taaaatcaac aaaatgaatc cagcaagatt ggaagacaaa agatcaatat     6120

atgaaagatt tattgatcgg tttgggcaat gtatacctgt gaccctccga aggcaggact     6180

taagctttaa gagaatcatg agtttgagac caacctatgt attcataaaa aaaattaaat     6240

atattcattt gaaaaaaaag ataataaata acaacaaacg ctggccctta tacactcctg     6300

atgggaacgt gagctgggcc agcctctagg aagtcaaaat ggaggttgtt aaaaaaaaaa     6360

aaaaaaaaaa aaaagctctt ccatggaccc agctgtattt atgcaaagga ctctaagtca     6420

gcatatcatg gagtcacttg cacatccata cttattcata atagttaagt tatggaacca     6480

accgaccatt aaaaacagag gaatggatga ggaaattgtg gcattttata tatatataca     6540

cacacacaca cacactcact cacacactct cactctctca cacacactca ctcacactca     6600

tactcatgca cacacttaca cattcactct ctcacactca catacatact cacgcacaca     6660

ctcacacaca catacacact cacacaaatt tcagccataa agaacggagt gacagcccag     6720

cgatggtggc gcacaccttt aatcccagca cttggaaggc agaggcaggt ggatccctga     6780

gtttgaggct ggtctcgtct acaaagccag tttcaggaca gccagggtca aacaaaacca     6840

aagccaaacc aaaaaacaaa acaaaatggg aaatgtttga cagaaaatag acaaaaaact     6900

gagataatca ttttaagtga actgaaccaa tctcagaagg acagatctca tttgtttttt     6960

catttgtggt tcctagattt tattaagacc cgtaaattca aacgtacgct gcgaaagcag     7020

aaacgaaact gggagaccaa gggactaaca ggaaatgggg gatgggcaaa tggggagact     7080

atggctaatg tagtgtatac atgtatagaa ctttgcacag ccttagccag tgtcattcta     7140

ctactcaggc cagcctgctt gaggctgcct cctcctatgt cctgtctcag gaaagcagga     7200

agtgtgagag gctctaccct ccagctctct gttgccccct gcctgccaca gaccccagac     7260

agagaagggg cttgggagca aggtgcctcc tgaggatcct cgggacttgt ttctgataag     7320

gtcagctggg cttttaagca gggatggatc ttgattctaa agctttctag gtttcggagt     7380

gcgggatctg gagtccacaa ggccatagag ggtttcaggg tttgaatact gaaagggaag     7440

ccgggagctt tctgtgtgag tagctgcctt cttccctctt cgagggttct cccccccctc     7500

cctcctgggt gttcctggac agccatctat tgtccccctc cttgaaaaga agccaaaatt     7560

cagatctcaa ttgatttggc tgaactgtct cctcaccgtc tcacccaccc tgaaactaca     7620

catctgatac tcacacacgc acaccccaac acgcatactc ccaaacacag acacaatcta     7680

gtgattttat ctatttatgt ttttaaatcc gcagttccgg gaattgaatt cagggcctta     7740

cctgctaggc aagggctcta tcaccaaact ccctcctcag cctatcgtct ctattttttt     7800

gagaaattaa aaagaaacaa gacagcccag agaaggaaac aataggaagc acagtttaag     7860

agcccagaaa tccgttccag cgtcaggtta caagttatat tcagttagaa aacgacgggg     7920

ttggttgttc attttattga cgtttgattg cctttaatga ggtggatcca acacctgcct     7980

gctgcggctt gttgatcgtg ctcctgtgtg atgtgtggag ttctttgggg tttaggggag     8040

cccaattctg ggagcagcct tgcctagaag gcagaggcag agctcaaggt taggatttgg     8100

tctgatggag cctctcagat tctctcaggc tttggatgac gtattgactt ttatccctgg     8160

aaaggttttt atccctggaa aggtttttat ccctggaaag ttctagcaag tttcatttta     8220

tgtctcccca ccacctccat ctcggagtcg gttatctaaa tctcaggagg ggcagaatgt     8280

accttattat ttatggaata atgattagaa acagtaacct ggcacaagag ggtgtggtgg     8340

agcttggatc atagatcggg cctccggtct aagtagacta gcacttcctc aacagtgggc     8400

aggccacaca ctccatttta tgtgcagttt tttccgtttt tttctttttt ttttaattct     8460

ttaactttta atctttggcc attgtaccca tttgaaaata cgactattag taattctcta     8520

ttgaatttcc tcattgtctt ctaatagaat aaaatagcat atctctttct gtatatgtgt     8580

gcgtgttgtg gtatgctcac tcactgttct gtgtgcattc ttcaggtgct atcttgggtc     8640

ttttgctggc ctgaaactct ccaggtagct caggcagcct ggctggtgtt ttaaaaactc     8700

cacattttaa tgtgtgtgct tttggaacta ctgagtgact ggtgagtctg agcctatctc     8760

tggctgacta gctgatttaa gttatgattt agtgcaatag gaaaatgaag actgtagtaa     8820

ccatttcttc agaggcttct agcaaaatga gataagaaaa tgatttatgt agttatgggt     8880

acttctgaat gcttctaagt cataatgtaa acattgattt acatttaaat attttaagtt     8940

attcatatat aaaatatgaa atgttctata tatcataaag tggaaacata tttagattat     9000

ttgacagcaa taataaaata tataaataat atgataaact caaatacttc tcaaatttat     9060

ttatacatat ctatttttgt agagagatgt gaataaattt caggacacaa tgccaaatag     9120

gaccagagag ttactttaga atgataagat ttaaatgatt ttcttttctt ttcttttctt     9180

ttcttttctt ttcttttctt ttcttttctt ttcttttctt ttcttttctt ttctcttctc     9240

ttcttttctt ttcttttctt ttcttttctt ttcttttctt ttcttacttt tccacacttt     9300

ctctgtgagg tgttttacac ttagtgtctt cagtaacaaa aacaacagca agcatttcaa     9360

aaatattaac agtgttaatt tcccacaagt tcaagtcacc agtttaggtc ccataaaatg     9420

aggccacagt gtggtccccg ttcttataga gtgagtgact aaactcaccc atggtctcac     9480

aaattccatg aaactgattg ctttttgcgg ggctatgagt agagaaatgt gtgacccaaa     9540

caggaacaag caagcaagat ggaacgtcag gtaccatgga gaggcctggg aagctaagag     9600

gccttaccaa ctccttcaga agcagtcacc tcatagaggt gcagggaaga gtgagctggg     9660

atgggcacag gggccagatg cccatcacac catgtccaga ctcactgtca cactgacctc     9720

aggtcataac gtgggggaag gtgttgttct gtgggaaagg gacttgtaag gaggaaggag     9780

ggtgtggggt gggaggagga gaagagatgg tgggatcgtc aagggtaaac agaaagggtg     9840

atagacataa atgaaagaaa tggtcaaaga acaagcctag ccaattaaaa caattaaaag     9900

ttttaaacag ctctctttaa gctctcacct ttcttactct ctagccctcc ttctctctct     9960

cttccctcct ctctccacgt ggccatagcc ggcatctctc tctttctacc ttctcccttt    10020

ctccctgcct tcctacaata aagctgttta aaaaaaaagt tttaaacaaa agaaatgctg    10080

ttgaatttgt gatgcctgaa aaggcttatt aactaaattc cttgaccgta taatattata    10140

ggaaagtatt ctaaggaaat aggattcaga gatttacatt ttaaaattat cctgagttta    10200

ataatgactg gttatgtgaa ttacgtactt atggtagatg ccttatggat actaaaatct    10260

gtgttataga gaaaaaagac atcagaacgt attttcagta ttattaatgg gaaaaaagca    10320

tgattaaaat atttggcaga ttaagcagta aaatattact acatatttat ctttggttgg    10380

tggaattaca ggtagtttta tttattttta aaatattatt ttattattta atgtatattt    10440

aatgtatatg tcttcagaca caccagaata gggcatcaga tcccattaca gatggttgtg    10500

agccaccatg tggttgttgg gaattgaact caggacctct ggaagagcag tcagtgctct    10560

taaaccattg agctgtctct ccagcccaga agtcttgttt ctttttcttg tggatttttt    10620

ttccctatta aatgggattt taacagatta aactgcttta aaattttaag ggtgtttggc    10680

ctaatgttga tcaacacact ggccctaagt taaggtactt ttgtgattac atcatggatt    10740

tgggaaggac gcatgttctc tcctgggaga gattcacagc tagaatatgc cccctgatct    10800

gtctgttcac tttgggtttc tctgaaagat gtgtgagctg ggtttttttc ccatatgaag    10860

ttgagtattg ttctttcaaa atatataaaa acattgtatt ggaatattga tggggatagc    10920

attgaatctg gagattgctt ttgataaaat ggccattttt actttgttaa tcctactgat    10980

ctttgagcat gggctatctt tccatcttct gataccttct tcagtttctt tcttcaaaga    11040

cttgaatctt ttgtcatgca ggcctttcag ttgcttggtt agagttaccc caagatattt    11100

tatagtatct gtggctattg tgaaggatgc tgttctcttc tcttctcttc tcttctcttc    11160

tcttctcttc tcttctcttc tcttctcttc tcttctcttc tcttctcttc tcttctcccc    11220

tcccctcccc tcccctcccc tcccctcccc tcccctcccc tcccctcccc tcttctcttc    11280

tcttctcttc tcttctctct tgttttactg agtcctgcct ctctggggta cccaggcacc    11340

tgggagggga cagggcaaag tccgaatctt tgggggaagg caagtttcca gttctctaag    11400

aacttggttc taatgctaag ttttcttaag agcatttgtg ctgacgccca gactgagagg    11460

cacttcctgc cctgccttgg acttcctgga agtcaacttc ctgtcttcta caccatacag    11520

tctttaacac gggaacacac ccagcatttc ttttcattct cttattttct cttcctctcc    11580

aagtctaaca atttatttaa gaaaggtgct tatttttcaa agctggcaac ctggctcaat    11640

ccccaaaacc cacacaaatg tggaaggcag gagctcttcc cagaggtcct ggtacacttg    11700

ctgtggcaca cacatgccta tacccaacac acacacacac acacacacac acacacacac    11760

aaataatgaa ttcagtaaaa gggaaataag tcagaactta tagaagatga gagaaatgtc    11820

tttgtgtggt gtcattccaa caattaatat gtgaatgtac tgggcatggc actcatcttc    11880

aattccagct cttgagaggc catggcagga agacagtacc ggtgcacact gaattccaga    11940

acttttttcc ttttttcctt ttttcctttt ccttttcctc ccctcctctc ctctccctcc    12000

cctttttcct tttctccttt tcttttcttt ttcttctctt ttctttcttt tctttctcgt    12060

cgtactgagt cctgcctctc tggggtaccc aggaacctgg gaggggtcag ggcaaagtcc    12120

gaatcaggga gtccacaatg attcctggtc ttctctctgg cgtaccatcc cagggagtca    12180

ggaactggtc tgcggtcttt gcttctcctc agggcatctt tgtgacaagc aggagagggg    12240

agatggagcc ccacatgagc agaattcagt ctgattagga gtgaggggct ggagaggagg    12300

cagccttctt ctggagtctt aggcatggct ccttagtcaa aggccttctt cttgggtgat    12360

ccttaatgga gcagctttct gagacaatcc ttgcttgttt tttattgctt tatttgatgg    12420

tggatgtaaa tgcgtacact ttattcggga tgaccaaggg gttatatacc ttttgggggc    12480

aggatatcca ggaagggaag ctcattggct gaaggctcaa ggctatctag acacctcatt    12540

aacatgaaga agaattccaa gtgttatgct atgtgactga ctgtctggtc ttctcagtgg    12600

ggtgtagtgg ttacatgttg tagagcaggt acagagacag gtagggaatg gctccattcc    12660

tgccaccaaa tctctgagat tcctggtttg agctcattca gccttaaatt cttatgcctg    12720

tctggtagtg cattcccaca tgtcctacat tctaacgttt ttcctccttt cttgtggttc    12780

ttctatttct ctccctacct gggacccctg gctgggatca gaagtccagc cttcctgtct    12840

cccctgccca gtcataggct gatcatcatt ttattaacct atcagagata attggaggat    12900

attctttaca taacattgac acaggagata gttcaacaat caatacaaag ctagtgttca    12960

tactgtaacc agatctctgg gcacagaaat cagccaacac acaattagcc caccaccatt    13020

tgttggagat gttttctttc tttttttttt tttttcaatt gtatttttct ggcttcttta    13080

tcaaaaccag gtgttcatag gtgtggggat ttacttctgt gtcttcaatt tgattccact    13140

gatcatatac ctgtctgttt ttatgctaat acaatgtgaa tttattacta cagctctatg    13200

acagagctta aaaccaaggg tcgtgcggga cgtggtggcg cacgccttta atcccagcac    13260

tcaggaggca gaggcaggca gatttctgag ttctaggtca gcttggtcta cagagtgagt    13320

tccaggacat ccagggctac acagagaaac cctgtctcga aaaaacaaac aaacaaacaa    13380

acaaacaacc ccaaaataca aaaacaaaaa aacaaacccc aagggtcgtg atacaagttc    13440

cttactgtac aggatggttt aatctatcct ggggtttttt ttcccatatg aggttgagta    13500

ttgttctttc aaagcatata aaaacattgt attgaaatat tgatagggat agcattgaat    13560

ctggagattg cttttgataa agtggccatt tatttattta ttttgttttt tcaagacaag    13620

gtttctctgt gtagtcctgg ctgtcctgga actcactttg tagaccaggc tggtctcgta    13680

ctctgaaatc tgcctgcctc tgcctcccaa gtgctgggat tacaggcatg tgccaccact    13740

gcctggccta aaatggccat ttttactttg ttaatcctac tgatctatga gcatgggaga    13800

tctttccatc ttctgataaa cttcttcatt ttctttcttc aaagacttta atcttttgtc    13860

atgcaagtct ttcagttgct tggttagagt taccccaaga tattttatag tatctgtgac    13920

tattgtgaag gatgctgttc ccctgatttt ttttctcagt gatttattat ttatgtatag    13980

aagggctagt gacttttttg tttgttcgtc tgtttgtttg ttttgttaat cttgtatcca    14040

gccacttcac caaaagtgtt tatcagctgt aggagttccc tggtagaatt tttgaggtca    14100

catatgtata ctatcatatc atctgcaaat agcaatactt tgacttcttc cattacaatt    14160

tgtgtcttct tgatctcctt ttgtcttact gactagctgg aacttccagc actatgctga    14220

atagatacag agaaagagga cagccttgac ttgctcctga ttttagtgga attgcttttg    14280

agtttctctc catttaattt gatattggct atacgcttgc tgtaaattgt ttactttact    14340

atgctttctt tttttttaat tatatttttc tgggttcctt atcatgttta ggtatgtcca    14400

ttgtatccca aatctcttcc agacttttaa aatgaatggg tgttggattg tgtcaaaggc    14460

tttttccaca tctaatgaga tgacaatgta gggttttgtc tttcagttcc tttatatgat    14520

ctattacatt gatagatttt catatgttgc gtcatccctg catctctagg atgaagccta    14580

cttgatcaag gtagatgatc tttttggtgt gttcttggat ttggtttgtg agtattttat    14640

tgaacatttt tgcatcggtg ttcatggggg aattgatctg taattctctt tctttgttga    14700

atctttatgt ggtttcagta tcagggtgaa tggcctcata aaacaatttt ggcaatgttt    14760

cttctgtttc tgttttgtgg aataacttga ggagaattgg cattagttct ttctttgaaa    14820

gtctggtaga aatctgtgct aaaatcttct ggatctgttt ttatgttttt ggttttggtt    14880

gttgttgttg ttgttgtttg gtttttgttc atttgttttt gagttgggag acttttaatg    14940

actacttcca tttccttggg ggttataggt cttttaaaaa tgtttatctg atattgattt    15000

aactttggag agtggtatct atcaaaatgt ccatttgtct tagatatttc aattttgtgg    15060

ggtacagggt tttgaagtat gactgaatga ttctttccat ttccttagtg ttgttttaaa    15120

tccccctttt cgtttctaat tttgttcatt tggatattct ctcttctttt tagttaatct    15180

agataaaagt ttatcttgtt ggctctcaaa gaactaactc tttatttcat tgattgcttt    15240

gtattattct catttctatt ttagtaattt cagccctcag tttgattatt tcctaccata    15300

tactcctcct gagtgtgttt gcttcttttt tgttctagag ctttcaggtg tgctgttaac    15360

ttgctagtat gaaatcttct ttatgaagcc acttagtgct atgaactttc ctcttagcat    15420

tgctttcatt ctgttccata agtctgggta tgtctggcat taattttcat tgaattctag    15480

gaagtctctg atttctttct ttatttttgc cttgacccag tagtcatgca gtagagagat    15540

ggtcaattac tacaaactgt agactttctg ttgcttctgt tgttgttgaa atcgagcttt    15600

aatctgtggt agtctgataa aagagcttat ttcaattttc ttgtatctgt tgataattgc    15660

tttgtgactg aacacgtggt caattttgga aaaagctgac aaagtgctaa gaagaaggta    15720

cattctgttg tgtttgggtg aaatgttgta tagatagctg ttaggtccat ttggttcata    15780

acttctgtta gctccactat ttctctactt agttttgcct ggatgccctg tccattaatg    15840

acaatggggt atttaagtct tccactaatc atgtgtgagg ttcaatgtgt aatttaagcc    15900

tttgcaatgt tccttttatg aatgtgggtg ctcttatctt tggggtagag atgttaagga    15960

ttttttgttt gatgagtatg gtatccttcc ccatctcttt tgattaattt tggtttgaac    16020

tctatcttgt tggatatttc aaaagatata acagctttct tcctctgtcc atttacttgg    16080

aaaatggttt ttctatcttt tactctgagg taatgtctct ttgttggtga ggtgtatttc    16140

ttttatgctg cataaggaag gatcatgttt tcatagccat tcttgtagcc ggtgtttttt    16200

ttattgggga attgagtcta ctgatattga gagatattaa tgaccaaaga ttattaattc    16260

ctgttatttt gttgttgtta gtgatggtgg tgtgtgtgtg tgtgtgtgtg tgtgtgttat    16320

tagaagcgtt ctcacgcccg gccaggaaga acaccacaga ccagaatctt ctgcggcaaa    16380

actttattgc ttacatcttc aggagcaaga gtgtaagaag caagagagag agaaaacgaa    16440

accccgtccc tattaaggag aattatcctt cgcctaggac gtgtcactcc ctgattggct    16500

gcagcccatc ggccgagttg acgtcacggg gaaggcagag cacatggagt ggagaaccac    16560

cctcggcaca tgcgcagatt atttgtttac cacttagaac acagctgtca gcgccatctt    16620

gtaaaggcga atgtgggcgc ggctcccaac atctccccct ttccttttaa taagagcaaa    16680

taggccaccc atattaatga gagtggagat agaggtcaaa tccccagtgt gtaggtaaag    16740

gagccatgta caggattagc tcttaggctc acaggctttt acccagagca accctgacct    16800

gctcccgtgt cgttttgcct ggagagaagg acacttggac actcaacctt cttgaaagat    16860

gacatgtctc cctagaatag gctcatatat gccgcagagc ctttctactg cagtgcttag    16920

ccgtgcaact ctctcgggct gctgaagcac actcactcta tcccgtgcaa tgagactagc    16980

ctcatgggat ataagagctg agtggccagc gacctattgc ctaagcatag atatatcagg    17040

ggaagctcca tgttctagtc ctgcaagcgc ctgggcaata accaccttgt ctctcctagt    17100

ttgggcctta agcttacaga ccaatcaaag aagcaacact aatccacagc aaagtgtatc    17160

tccaaataat attaatccca cccatttttt aaagaaggaa aatgctgagg agatccaatt    17220

gggtaatcct ttggtcagcg acaggtccaa gcgcgtggag ttgacctgaa gtctcaattc    17280

ccgaagggat ctgttcaaat tcagccgtcc aattctgtaa catatactga aaaagacttt    17340

ttgacaaatt agctgtccta gtaaatttct catactgaat ggaagtaaca cacaatctcg    17400

gaaacttttg ttcacatctc agctgagcta tttgccataa tacatctagt tgtttctgga    17460

caagatctat gagttgatta accagcatga gacctctctg tatctagaca ttagttgagg    17520

cctgtttatc tatgactgta gtcactgagg ctgacaaagt gttaatggtg tcagtcgtct    17580

ggacctgtcc agacagagcc aaggctgtct gaatcaaggc taaacccagt tcctagttag    17640

tggtaaaaaa gcaggagaat acttgagcat tatacatcac cgtcattggg agtggaaata    17700

tcgacattct cccccaacgc tgctctcttt ttattattga cgccctggac atcaccaaga    17760

cgagggacat cagtattccc ttggtcagtc tggatttttc gggtgagtct ttctggtatc    17820

caaaatgggt tgtcttcatt ctgtgggaaa acacagatag ctcccctgga tcttatcaaa    17880

ataggatccg ggccatacca tttattatca aggacatttt tccatttaac catctcattg    17940

ggcctatctg gctctgaaca atgacgttca gccgcagtat ggccatgagc atcaatattt    18000

aaaaaattga gtgtaaagag tgccaaagac acagacactc ttggtgctcg gggtaaaatc    18060

tcttcaattc ccctcttctg ttttataaga taggttttga gggtgcgatg cgcacgctca    18120

acaataccct gtccttgagg gttgtatgga agtccagtca ggtgggtcac gtccatctga    18180

cggcagaact gttggaattt ttgagacgta taagctggtc cattatcagt cttaaggagt    18240

ctgggtttcc cccaagcact ccatgcctca agacaatgtt gaatcacatg tgaggctttt    18300

tctccggtta acggagaagc aaacatgatg ccagaacatg tgtcaatgga cacatggaga    18360

tattgaagtt ttccaaagga agaaacatgt gtaacatcca tttgccagac ctgtagaggt    18420

cgaataccgc gtgggttaat tcccacatga ggaactggca agaactcaca gcagctttga    18480

cattgagtaa caatgtcacg ggcttctttt cttgtcaggg agaaacgact gcgtaatgtt    18540

tcagccgtca catgaaaatt gttatgaaaa tttcttgcag cctctaccgg ggatgatagg    18600

gcagcagcca tcactttagt ggccttatct gccaaatcat ttcccagagc catggggcca    18660

ggtaggcctg aatgggctct aacatgagta atataaacag gaaatcttct agataacaaa    18720

actaattgta tctgctgaaa aatattggct actctactgg aaggcttaat cactccagcc    18780

acttctaaaa gatttactgc attaaccaca taacaggaat ctgacacaat attaaggggt    18840

tctaaaaagg tttttaaaac ttctaagacc actaaacatt ctaccacttg aggtgaaatt    18900

tcattatact gtttggatac cactttacca ttagccacat aggcacctat gccagttttt    18960

gatccatcag tatataccac aatcccattt ttaagtgggt ttcttactgt tatttgtgga    19020

aacacaacag attgattttg gacaaactgt aaaagtggat gttttggata atggttatct    19080

atttgtcctg aaaaggaggt aactaaaact gcccaatcat tagatgtggc tgccaaggtt    19140

tgaacctgtg cagcggtata aggtacaatt aaaagatatg gacttcgccc aaagtgggtg    19200

attgctgctt ttagaccttt aagggcaagc tgtgcaattg catcaggata ccaatctatt    19260

attttagctg gggatacgtt tggatggatc cacaacaatg gcccattctg ccacaaaact    19320

gcagttggca attgtgctgt cttaaagaca cacaaactga aaggctgcga atcctcaata    19380

cattgtaatt gtgcattctg taaggcattt tccacttttt gtaaggcctg gttagcagct    19440

agagtaagag tcctagggga ggagatatga ggatctcctt ctaaaatacc aaacaaaggc    19500

cttaactcag cggaaggaat ctttaaaaaa ggtctgagcc aattaatatc tcccaacagc    19560

ttttgaaaat catttaaggt atggaggtga tctcttctta tctctacctt ttggggcaca    19620

atcttatctg gggacaccac agagcccaag aattgtcctg tatcagaaat ttggaccttt    19680

tctgtggcta tctgtaaacc ccactgactt aaagttttaa gtagaaaagg atatgccttt    19740

tgtagcatgg taaggtcttt atggcacagg aggatgtcat ccatgtaaag gagcaaaatt    19800

aaagagggga attgttccct cactggcaaa agagcttctt gcacataaag ttggcacatt    19860

gtaggactat tggacattcc ctgtggtaag accttccatt gatacctctt atcaggttcc    19920

atgtgattaa tagaggggat ggtaaaggca aatctgggcc tatcccttgg acacaaaggt    19980

atagaaaaga aacaatcttt aatatctata ataattaaat tccagccacg tggtaaggcg    20040

gaaagtacag ggagacccct ctgtactggg ccaaataagt tcatttgctc attaatggct    20100

ctgaggtcat ggagcagtct ccactttcct gactttttct taattacaaa aattggagta    20160

ttccaaggtg aggtagatgg ctcaatatgg cctagtttta attgttcctc taccagttga    20220

atcacagctt ctagtttttc agaggatagg tgccattgag gaacccacac tgggtcccct    20280

gttttccatg gtatgggtcg tgctgcccca atggccgcta tggaaaaccc agaccctgtc    20340

tgtcttggtt tccattaggt aagataggct ctatccttcc ctgttcttga tgtcctaacc    20400

cttttccttc tttataaccc atctttgcca tgatattttt tgctttagtt gaataccctc    20460

ccgatggggc gttttcattg gacaaaataa ggcccaaatg ctgcataata tcccttcccc    20520

agaggttaac cgggagtggg agcacataag gtatgaattt cccttgctgt ccttcagagg    20580

attcccacgt caaggcaacg gagcttatag tgggacatga ttgatatcct aggccctgta    20640

atgaatgaga tgactctgtg gtgggccacg ctttgggcca ccaatgtgta gagattatac    20700

ttttatctgc tccggtatca aggatgcctt caaactcttt tccgttaatc ttaaggcgga    20760

gcttaggtct atcatttaaa gatacaacca aataggcaga atcatttcct gaggagccca    20820

ttttctttat ctcaggtcct gcagatttct ccctggtatt atcagggagg agcagcagct    20880

gagctatcct atctccttta ctaatagaaa aaacgccctt agggcttgag cacaggacct    20940

gtatttcagg ggaatgttga caatccataa ctccagggtg gactactaag ccctgcaagg    21000

tgagtgaacc ccggccgaga ataaggccca tggttcccgg gggcaaggat ggtataggct    21060

ccactggcac cggctgaata ctcatttgag gcattaatag gaagtcggag gcggcacgca    21120

ggtccaccct tgtgggtctt cctgggtcgc ctctctgact gcttcctggg tcctgacaaa    21180

ccggttccca tatctttgag ggccctggga ccgagggccc gatgacccgt tttttggcac    21240

ataagctgat tgactatcag gtgggggaag aattctgccc tttatatccc tcacagagcg    21300

acactggtcg gctctatgat aacccttgcc acacttagag caaagagtga gagtccctcc    21360

ctgtttatct ggagctctgc aatctttctt aaaatgccca ggctttccgc aattaaaaca    21420

tgtcctctga tcatttctgc ccatggagcg gttctgagat tgaaggatgg cggccgctaa    21480

gcctgcattg gtgagaggtc ccccaagctc tcgacagacc ctgagccagt cttgtaagcc    21540

tttgttcttt cttggggcta tggccgctcg gcactccttt gtggcttgct catagattag    21600

ctgttctacc agaggcgcgg cttgctctga atctccaaaa atacgctctg ctgcctctgt    21660

cattctggcc acaaaatctg agaaggattc ctgaggtccc tggacaactt ttgttaattg    21720

accagtggtt tcacctgctc gggagagcgc cttccaggcc ctaatagccg tggaggaaac    21780

ttgggcataa gctccccaat ggtagtttgt ttgatcagca gaataagctc cctgacccgt    21840

taacaagtca aaagtccaat ctctctgctc tggagtcaaa gcagctgcgt ttgctcgggc    21900

ctgcgcttgt gcagtttcat gccaaagagc tctccattcc atatatttgc ccatactagg    21960

gagagcggct tttacaaccg tttgccagtc ggcaggagtt agtgccatgc cggcaagcct    22020

gtctaactgc accaaggtaa aattagcatt ggttccgtat ttacggaccg actcggcaag    22080

ttctttaatt tgtaagtatt ctaccggagc gtggacacgc ccaccctcgg ctccttcaaa    22140

gactggaaat gcctgttgta ttttcctttg ttcctctctg ggaatgaatg agtctgcgca    22200

ctgcctctct gcgcactgcc tctctgcgca ctgcctctct gcgcatctct ctgcgcattg    22260

cctctctgcg catctctctg tgcattgcct ctctgcgcat ctctctgcgc attgcctctc    22320

tgcgcatctc tgacgcacta cgcagggcgg ggactccgca tagggcggac cttgaaaccg    22380

actgccctga ggccaatcag caaactggcc ttcgccagcc gcttttggct tccttaactg    22440

attagctagc actttacctg gctggtaccc ttttttctca taatgagctg cttcttcctc    22500

ccagtctgtt tcttcagagg agaattcatc atctgattca gagctaccaa gagctggctc    22560

cccgagccca tccagcgatg agcacaggct ccttttccta gagacctccg ctaattgatc    22620

tttcttcttt tccctttttc ctctttttct tctaatctct ctccaggtat tcctacctaa    22680

ccttaacttt tcctcgggtt caagaccctt ggaaaggcct gtatacttat tttgtgtacc    22740

atatttcctc tttgttccta ctctctctcc ccactttact tctgatagct tgtcctgaat    22800

ttcctctaga attttcagcc ctatcttaat cacttgataa catgtgaaaa ggaacaaaag    22860

ggctcctaac accagaaaaa attcaaggcc aaacattttc cactttactt ctgatagact    22920

gtcttgaatt tccttagaaa gttcaaggcc aggcttacct cgtaaagcta tactcactgg    22980

tactctcgtt ccccagctga aaagttctga attcatgcag ttgaatcctt cttaacagtc    23040

tgctttacgg gaacctttat taccgcgacc cgcagttctg gttctggaat gagggatctt    23100

ccttgcgcca gtcccgagtt ttttctcgtc ccggaattcg gcaccaattg ttattagaag    23160

cgttctcacg cccggccagg aagaacacca cagaccagaa tcttctgcgg caaaacttta    23220

ttgcttacat cttcaggagc aagagtgtaa gaagcaagag agagagaaaa cgaaaccccg    23280

tccctattaa ggagaattat ccttcgccta ggacgtgtca ctccctgatt ggctgcagcc    23340

catcggccga gttgacgtca cggggaaggc agagcacatg gagtggagaa ccaccctcgg    23400

cacatgcgca gattatttgt ttaccactta gaacacagct gtcagcgcca tcttgtaaag    23460

gcgaatgtgg gcgcggctcc caacatgtgt gtgtgtgtgt ttcccttctc tgggttttgc    23520

tagtgtgaga ttatttattt catgttttca tagttatagt taatcttctt gggttggagc    23580

tttccttcta ataccttgtg tagggctaga tttgtggata gatattattt aaatttgact    23640

ttgtaatgga gtatcttgtt ttctccatct ataataattg aaattttgct gggtatagta    23700

gtctgggctg ttatctgtga tctcataaga gtctgcaaga catctgttca ggcctttctg    23760

tcttttagag tttccattga ggaatcagat gtaattctga gaggtatccc tttatatgtt    23820

acttggcctt ggtttctgtt ttgcttttgg tcttttggtc tttgtggtct gtatttctgg    23880

tgactgttgt gacctccctc tctatttttc tgtctataca gggtctctct atgtagccct    23940

ggctaccctg gaactcacac tgtagaccag gctggtcttg aactcagata tccacttgtt    24000

tctgcttcct gagtactggg agtaaaggtg tgtgccacca ctggttggta aaggacctgt    24060

ttcaaaaaat gaaaacagct gggcttggtg gcacaagcct ttaatctcag cacttgggag    24120

gcagattcag gtggatttct gagttcaagg ccagcctggt ttacagagtg agctccagga    24180

caaccaggac tatacagaga aaccctgtct caaaaaatca aaagaaaaaa aaaaagaaga    24240

agaagaaaaa aaatgaaaac acagagcaaa agcaagaaca aacaaacaaa caaaaaaccc    24300

aaccctgttg cattagtttt caacccaata taagaaacac acaatctggt tattgtattt    24360

ataagctgta tgcctagatt gggcagatct agtgctatac tagtttctcc tggctccatc    24420

ttcgtttcct cctcttcctc tctcttctcc cttccttctt ctctttctcc tcctaactgc    24480

ccccactctc caagacctcc catcccacct ttcccttcca ctgcccaatc acagccttta    24540

gtctttattt gaccagttca aatggggaaa agattcacat gaggtctcat gagtatgtga    24600

tcagctgatt gacagggagc agcctgtctt gaggaagcag aattaacatc agaatacaaa    24660

cagcatcagg gaacccacag catttccctc ttttgttcaa taaaaaagga tcttttcttt    24720

caggtataaa ttgagcacaa ccataacaat tatgtaaatt gtaaagcagg atatacactt    24780

aacatctagt ctatcatatt tgtcagttag ataaagtact ctaccaccta ccctaattta    24840

aagagttaat aagtctatgt ctaaattatg ttgattttaa cttgtattcc catctgaaat    24900

ccatgcttac aaatctagat aatctttctt aatgttaaac catttaagtt tgattatgag    24960

actataacta gtcttcaatc ccatcagagg tctgagaaag aattaaatat tacctgaata    25020

tgtaggaggc acaatgacgt agcttccaag attatacaat ttgtagagac agctgactgc    25080

cctaatttct tataatgttg gatctgtctt tagccttctg gcccagaaca atctgacaga    25140

cctaagtaaa gcaggaactt tgaaggacta gcttaccctg ttttgacaga gcttaacaat    25200

tgactatccc acatctgttt gtcctttttt ggacagtatt tttgtctgca gatgaattag    25260

ggcacttctt gcccaatggc taccttgcca cgatcaaagc aactccccct ggaggtaatg    25320

atgctcaata gcctccttga agtggaatgt gatactgtca tgaacacatc tgtctcatag    25380

tcatatgatc tttgatgatg aaataatatt aaatgccata ttctgtgaat ctctgatgct    25440

tttgaagact atctaaacat ataccataac agaattgtca aacatccatt actcttagct    25500

atttactatt aaaataatct tgaaaacact tgtaattaac taaattagaa tctaataaag    25560

ccatgaattt cagtatctga cttgcatcac ttaatcatcc taaacagttt gtaacagcag    25620

ctattaaaag gactggatct aagccttgta ttcttaaatg agttacatag gcataatgcc    25680

tatctaagag taacaatatt aattttaaat tttgtactaa tatacaaaga tttataccaa    25740

tgaaaacctt aaacctgtat caatatatat aaatagtgta acaatgtaag aattaaaact    25800

tcaattttgt atcagatata aaggtttcta ccaatgtaag attatggtga tttgatgctt    25860

tgtttaagtg taaatttaat atcctatctc tatctgtcca tttgactata tttccccttc    25920

cctttccatc ttcctctctt tacctaagaa ggaaggatag agaagaggaa acgaaaggta    25980

gaaatccctg agtctaggct ctctagtttc ctccctgtcc aaagtcacac ttgtaagtta    26040

tccactaaga tgacaatata tctataactt ataaaatagc cagaactatc cactccaacc    26100

taagggactg ggacaacaat cttcttttgt ttgcttctag ctaaattggg gtgaggaatt    26160

cccttctggg ggcccaaagg ggaataggaa aattggtctt gtcaaaggca gactagctgg    26220

catcatttgc ctttcggtct ctatgtgctg agaaagttta tggcttagct gaagtcctga    26280

ctgtaatagt ctgaaaggct agatgagtga attagctgtt ctgaaactgt cctggaagca    26340

agtctttaga ggaaacagct ccgatgtagt tgaggtagaa tcaagcaagg agctggaatg    26400

gaaggacctg gaatctcagc gtccccgagt gtgaatcttg tcagggttgt ctctctcctc    26460

tttcattctt cagtatacaa accttacaag caactcgtgg gctctgtaaa gacattcatg    26520

tggaacgtgc agggtgcaca gattaattaa ggaagatcaa taaagaaaga caactgcctt    26580

tcttcagagg ttagtttgat cacataatca aaatacaata taaatagcta ttcctgccat    26640

cttaaaggat ggtagctaat aaaaagttat gaaaattttg tgctcaacaa gtgttattgg    26700

ctgtatatag acagttatat ctcagcaggt cccagagctg tctctgtgta cagagtcata    26760

tatacatcac cacatataca tcacttatct tgttgatctt gtcaatctcc ttttgtctgt    26820

agccaaggtc tttagggggt tctccccttg tcatgtctga tttttatcaa cttggaagga    26880

actcatagct tttcttttcc tgtggaaata taggcaaaac ctctccccca gagttagaag    26940

atctttaaag taaacaggct ggtctagctc agcgggtttt ccccacaatc caatgtcttt    27000

cagcagctat atttttttgt tcattaccat tttaaaaatt taaggttaat aaaacactat    27060

gaaatctatt tctgagagtc tttgttaccc ccttttgtct gataagcatc tcttttagag    27120

tacaattaga tctttccaca attgcttgtc ctgtaggatt atgtgatacg cttgaaacat    27180

gttttatata ataatatgtt aaaaactttt ttcatcttat tagacacata tgtcggacca    27240

ttttctgttt taatttgtat gagtattccc atcatggcca caacgtctaa caaatgtgta    27300

attacagaat ctgccttttc tgaagctaaa gcagttgtcc attgaaatcc tgaatatgtg    27360

tctattgtat gatgcacata tcttagttta ccaaactcta taaaatggaa cacatccatt    27420

tgtcaaattt catttctttg ggtaccttta gggtacttcc tggaggttaa tggagtttgg    27480

ttatgtaatg agcaagtagg acattgcctc acaatttctt tggcttgttg tcaagtgata    27540

gagaattctt tctttaaacc tttgttgtta acatggtgat ttttatgcaa tttcgaagcc    27600

tctagtaggc aggtctgtgg tgtattttct tggtcacgat tgatgtggaa ggccctgctc    27660

actgtgggca gtgccactga tggtcttggg tgccacagga aggcaggtgg agcgagttac    27720

gaggaacaag gcagtaagca ttgctcctcc attctctgca tccgtttctg tctccaggtt    27780

cctgccctga cttcccgtgg gtgatggact ctaaagctat aacagtaaat gaactttttc    27840

ttctccaggt tgcttttggt catgatgttt ttaccataac aatagcaaca aactgagaca    27900

agctccatga ccaggggttt ctctttcttg gaagttggtg tggctttgtt tgttagtagc    27960

tgaatgttac ttgatgttac cccagattca cagcttcagg agaaaggtag acttctaccc    28020

ttcatttaac acacaaagac atgtaaaata ctctgaggaa gcagcttccc gaggcagagt    28080

ggccagtgat acagccaggt ttcaatctag gaggagcccg tgttcccagc caggactctt    28140

actatcttcc tgcagagtca tcaacaatct agtctagcct ctttggggtt gttctactga    28200

actctggtgt ctgtccaatt tgtctccgca ttttgtatgc acttttcctt taagagccgc    28260

ttttcttgcc tcctccccaa aggtgtcttg ccctattccc aagactgtta aggcacctag    28320

gaggtgacta tctgaccagt ggctttctgt atattcacct ctctaaacaa aagcttccga    28380

gaatcaggaa cttcctgttt tgtttcctgt tattattctc catttttttt ccttctaaag    28440

tgtctggaat atggtagatg cagttagttt ttgacaggaa acaagctggt agctgacact    28500

taacttcctc acttgatcat tagcatcttg tgttgaccca ggttacagct cttctacctc    28560

ttgataagaa tggatttcca gagttgtctt tatgctattg ctgaagaact gggcagtgaa    28620

gacctggctg ccctcaagtt cctgtgcttg gactacatcc cacacaagaa gcaggagacc    28680

atcgaggatg cccagaagct atttctgagg ctgcgggaaa aggggatgtt ggaggaaggc    28740

aatctgtctt tcctgaaaga gctgcttttc cacatcagtc ggtgggacct gctggtcaac    28800

ttcctagact gcaaccgaga ggagatggtg agagagctgc gggatccaga caatgcccag    28860

atttctccct acaggtgggt agaaaggctg tggtgggggg actgggaagt gtgggctgaa    28920

gggggcatgc ccctgtgaca tgtgtgaagt gacttgtgag actgcgggct aaatgtaggg    28980

gctaaataca taattcagag aaacatgcta aagccataaa ataatgtatc tttcatacag    29040

catggtacag aaagggactt atgaggagga aaagggattt ggctacagga gtcagagaga    29100

gaccagtgta ggggaatatg attctgtgtg gagtagttac tttgctgttg ctgtggaaaa    29160

ataccacgac caaaagcaat ttatagaaga gtttatgttg gattacagtt ccagagtgct    29220

aatgccggag ataagatggt aactagcagg cagggcagca ggggcaggga gctgagagtt    29280

cacatctgcc atgcacacgg gaaacagaaa gtgtgacccg aaagctgggt gaggtcaaac    29340

ccctcaaagt ctgtgcctgg tgatcatgat gtgcttcctg ctgcaaggct ctgcgttcta    29400

aaagctccat aacctctcca gacagcctgg gaccaagtgt tcaaatacat acgcctagga    29460

aggaccctgt tcattcaaac caccacaatg tataatttaa atttttcatt tttcaaagtg    29520

aaacattacc ttctagtatg ctgatagtga gattttttta aagatttttt taatttttat    29580

tttacgacat aggtattttg tttaccgatg tgtctgtaca gcatttgcat gtaggcttcc    29640

tgcagaggcc agaagagggc attaaatcac ctggacatgg agttatagac agttgtgagc    29700

tgccatgtag gtgttgggaa ttggacctgt gtgcttggaa gagccatcag aactttgttt    29760

gtttgcttgt ttcactattt atttattttt atttatttta catcctgatc aaagccccct    29820

cccttttctc ctcccagtcc tgccctccca ccgcccttct ccctccccca ccccaccacc    29880

tgccctggca cagtaagtca cagcaggaga ctaagtgcat cctctctcac tgaggccaga    29940

caaagcaacc caggtagagg aaaggaatcc aaaggcaagc aacagagtca taggcagaca    30000

cctccctcac ctctgtgcct gctccagtta ttggagaacc cacatgaaga ccaagctgca    30060

catctgctac atatgtgggg gggcgggggc taggtccagc cccatatgct ctttgattgg    30120

ttgttcagcc tctgtgagcc cccatgggtg caggttagtt gactctgtag gtcttcgagt    30180

ggtccccttg acccctcagg ctctttcaat cctatccccc actcttccac aagactcccc    30240

gagctctgcc tgatgtttgg ctgtgggtct ctgaatctgt cagttgctgg atgaagcgtc    30300

tccgaagaca gtcatgtgag gctcctgtct gcaagcagag tttcaaataa gtattttagc    30360

tcttcctctt ctttcttgtt aaagaaagtt aagatgacag aggtttaaaa tagtctgggg    30420

acactaagga gaacaaacca ggattccagc aggctatgtg gtagctgctt ccaccagcca    30480

agaaggactg ggctctggag aaacaacaag gcattgttgc cctttccccc acgtaacctg    30540

agtaactttg taagtagtcc cacatttata catgttctga tgtagaaatt gtaatatctg    30600

atgtaacaaa ttgtaacaga caggattgtg ggtaatgatg acttctaaga gagtctctgt    30660

ctatcaggga aaggaccacc cagcctgccc ctggactggg caaggggagg gaaaatggag    30720

aagtctagag gtgtgctcac tttcagggat gttttctcac ctcctgaaat aagctggaaa    30780

tactttgcat tacacacgct gcagggtgaa ttctcaggaa cttaaaaacc gagactgcag    30840

gcctggatca ataagaaggc agattcacac atcggtgaca cacatgtatc ttggtggctc    30900

acatttaaag acacagaagg gttccatatg catacacaag caggtgggaa gggttgtcac    30960

tgtgggaagc agcaagaccc taaccatgaa caaacacatc ttgcccagcc tggaagtggc    31020

caccttctgt aaccaggcag gacttccagt ggagggatag agacgccagc ccacccacag    31080

aattttgtcc tgcctacaag atgtgtttgt agtctggggc ccctgcactc aaacattaca    31140

cctcacaaat ctcaggttaa tgaaaagtga aaaaggcatg ggccaggctg ttaggggact    31200

tggcagttta taaacaggct gttgccatat gtgagttctt tcaggggcgg gggtgggggg    31260

tgaatgaaga tttagtgaga gaacagagcc ccgaggactc cctggcaact aatgagattg    31320

caggtgggca gtggatgcat gcaaggagac acagggaatg tatggtgggg agagcacacg    31380

gcagctggct gtgttgagag ccttgggtgt tggtaagagt ggaaagaggt gtgtgtgtgt    31440

gtgtgtgtgt gtgttcagag tcccttttat tctagaacca aatattcagc ctcctcctga    31500

aggaaattgc tgagagaaca tggaccaatg cttagaaggg agtcagctct gttgtgcacc    31560

atggagaata taattccccc aaatcctcgc atctggatct tgatttttat atcgacatag    31620

gagcagggag attcttttag ttgaagttag ttggttacaa aggtggtggc acttcgcatg    31680

ggtgggttgg ttggacctga ctctatagac ttccaccagt caggaatagt tgactatttt    31740

aaggaagccc tgggagtgag ccctgctgtg actgtgtagt ggtgggaaat gatctagaac    31800

gtgtttctaa agtgcctctg tttcctgcca cagggtcatg ctctttaagc tctcagaaga    31860

agtgagcgag ttggaattga gatcttttaa gttccttttg aacaatgaga tccccaaatg    31920

taagctggaa gatgacttgg taagacctaa tctcctgaag atgggtcacc tctggggttt    31980

ctgagaccag agagccctgc taaacataaa tagtattcaa ggttgtgatg gtgttgttgt    32040

tgttttgaaa catggtatcc tatagcccag gctaaatcca aacttgctat ttagctgtct    32100

tcattagagt tttcctgctg tgaatagaca ccatgaccaa ggcaactctt ataaggacag    32160

catttaatta gggctggctt acaggttcag gtccattatc gtcaaggctg gaacgtggca    32220

gcgttcaggc agatatggta caggaggagc tgagagttct acatcttcat ctgaaggttg    32280

ctagcagaat actggctccc aggcagcaag aacaagggta ttaaagccca cacttacaag    32340

gccacaccta ctccaacaag gccacacctc ccaacagtgc cacacctccc aacagtgcca    32400

ctccctgggc caaccatgta caaaccatca ctgtagccaa agttgaccct aaacttctga    32460

tcttcctgcc tttatctcct gttaatgtgg ttccaggatg tggaactcag cactttctgc    32520

accgtaagca agcactctgt ccactgagca gcccctgtct tctcactaga agaaagtagt    32580

tagataggaa caggtaggta tggctctagt gcctctgcac agtgaagtgt tactcggcca    32640

cagggccgag ccagaagccg gagagagcaa gttgtgcagt tcaacaatac atgggaccca    32700

gcagggccaa ggagaaaagg tggcccaggg tcacatttcc ctacttctgc tgcccttgaa    32760

acacggcgtg ttcgccccct ctcactccat cccggtgtgt attatgtgtc tttatgagta    32820

ggttgtatga tgtgtctgtg tctacatgtt gtgtatattg tgggtgttta tgtgtggtgt    32880

aggtgcctgg gtatacctct gtgtggcttc tctgttggtc tgagtatata tgtgtgtgat    32940

acctgtgtgt tggcgggggt tgggggttct ctcactctgt aaatcagtgt gtctctgtgt    33000

gctctgtggt agatggccta aatttgatgt atgctttgtc cagatgtatc tctgtgcgtt    33060

tgcttagggt acccgtgaac acaagtgtgt ggcatctttc tgtgtgttcg gtgcatatga    33120

ctctgtgtgt attaactgag gtttagagaa agctaaggta ccaggggcaa tactggggaa    33180

taattcagtc tctaggattg gcccatccac attcctcagg ctggtccata gctgaaggca    33240

ttctcatact ggttgagaac aagacctggg gactgggtga cacctgacat ggcttattca    33300

tctttccatc ttttaaaata ctttcaggcc ttcctgagta ctgtcacctg tgagagatcg    33360

gcctgtgctt ggaggtggga gggggatcta tgtgggaaat aagactgggc cctgagtttg    33420

gaagaagtag agactaaacg aagccccaaa tctccaagcc tgtgctctca agccttttgt    33480

gcttcactct cctccccaga gcctgcttga aatttttgta gaaatggaga agaggaccat    33540

gctggcagaa aataacttgg aaaccctaaa atcaatctgt gaccaggtca acaagagcct    33600

gctggggaag atcgaggatt atgaaagatc aagcacaggt agccagctag tcaacagctg    33660

cgagttggga aagccctcag agaaacagct ctttctgatc aaatttttct ttttcaattc    33720

agagagaaga atgagccttg aaggaaggga agagttgcca ccttcagttt tggatggtaa    33780

ttcgcacaga tacattcctt agattctgag gtgcttgatt tccgacttcc tcttgccttc    33840

tacccaccat cttctgcctc atcctgatta agatgaaagt tcagtggcct cttgtcacct    33900

ctgcagctct ctgaaagccc catggaaaca ttctcacagt tactctgtaa gaggctctta    33960

actctgctct ggcctttgct tttgaagaga gttgtgggga gctagacaca aatcttttcc    34020

tggacatcct tttgttttgt tttgttttgt tttgttttgt tttgttttgt tttgttttgt    34080

tttgttttgt tttgttgaga cagggtcttt ctacctcatc ctggttgtct tggaactctc    34140

aatgtagacc aggctggcct tgaaatcata gaaatctatc tgcctctgtc tcaagtgtta    34200

ggatcaacac ctgacttttt ccagaatgtt gttaaccaag tttcttcaag tttttctgct    34260

ctgtgagagg cccctcagcc aagtgtctcc tgttaagccc aggcacccag gtccacacac    34320

acctgagttc ctccattgtg tgcctgctcc atcctgggat actcaagcca agttgcctag    34380

ctcatcccag aatggaattt gtccagtcct ctgtttcctt acctaggaaa ctggatagaa    34440

caaacagaag gattccttca acgtagggtg tctcagttag ggttctatta ctatgaagag    34500

acaccatgac ctaggcaact cttataaagg aaaacattta actgaggctg gcttacagtt    34560

tcagaggttc agtccattat tgccatggta ataaaacggc agggcaggca gatgtggcac    34620

tggagataga gctgagagtt ctacatcttg atcctaaggc agcaaggaga ctgtgccact    34680

gggcatggct tgggcatatg agagatctca aaccccacct ccacagtgac atacttcctt    34740

taacaaggcc acatctccta atagtgccac tctccagggg ccacacattc aaacacacga    34800

gtctatgagg gccataccta ttcaaaccta ttctccctat gtagctagct agcctggaat    34860

ttgctatgta gaacaggctg gcctccaact catagagatc catctgcctc tctctgcctt    34920

ccaagtgctg gggttaaagg tgtgtgctac aacacctggc tctttcattt tttaaaaaat    34980

ttttatttat ttttcaacta tgtgtatgtg tgaaaacatg agtacatgag tgtaggtacc    35040

catgaagtct ggaagagggc atcagacctc ctgaaactga agttacttac agatggttgt    35100

gagccaccat attgatgctg ggaacctaat ctgcacactc tgcaagagca gccagagctc    35160

ttaactactg agcatctctc tagtcccctc caaatttttg attaatctaa tattctgatt    35220

ataaaaattt tctgtgctct tttgggggca gtttttaaat tcagagaaaa ttaaaacacc    35280

atcactactc tgtaaatact aatattgata atatctcttc tgctctcact attgtttttg    35340

ctgtgtaata tattttggat cactctttat tttaaattta tgtgtaaatg tgtgtggctg    35400

agtaagttta tgcatgctgc atttgtgtag gagcctgaat acgtcagaag atagcatcag    35460

atcccctgga actggagtta cagatggttg tgagccacca tgtgggtgtt gggaatctct    35520

ggtcctctgc aaaaatgtta aggtctcaac agctgagcca tctctttagc cgtgaggata    35580

atcctccttt aaagactgtg cctgagtaag agagccagtt ctttcttcca tccacgcaca    35640

cctaagccta gctctttcca actaccttca ggatgtttga ctcagtgact catcctgggc    35700

tcacgctttt aatcagtaac cgcctagcaa atgaggcaat gtgctcttgg ttttcaaggg    35760

gtgctaagta cccttcctac aagattgata tatctgaaat atgttcaagg cagtttcaat    35820

gtttattttt aaaaaatacc taagaggcca gtgaaatgcc ttagtaggta aaactgtctg    35880

ccatacaggg caggtgatct gagtttgatc tctggaacac atgtaggagg gaggaaggga    35940

gccaatctgc agagtcctct gtgatctcca cacacacatg ccatagcatg agagctccct    36000

acatcaacac acacacacac acactctcca cacacacatg ccatagcatg agagctccct    36060

acatcaacac acacacacac acacacacac acacacacac acacacacac gcatgcacac    36120

acgtgcaaga acgcacacat tcacgtacat acgcgtgcat gcacttgcat cctgaaaatg    36180

ttttaaggtc cttaggttgt cctaagtgtg acgttttttt ggttgcttgc agagatgagc    36240

ctcaaaatgg cggaactgtg tgactcgcca agagaacaag acagtgagtc acgggtaggt    36300

gtgtctccta cctctctctt tgcattggtg ttcctgtttc ctttggttgg ttccttttca    36360

gctgccagat aagccaataa ggggtagagc cttttggaaa ctctggagag aaaaacagaa    36420

aaaacaaaca aaacaaaaca aaacaaacaa aacaaaacaa aacaaaaaaa ccaaacaaac    36480

ctacaaaaga accagttaag atagcctctc cagttttctt tgtgttacat tatcactgtt    36540

ttgtttgtcg tttgagacag tgtctcctat agctcagatt ggctttgaac tcattatgta    36600

gctgaggcta accctgaact cctgattccc ctgcctttac ttcccaagtg ctaggattat    36660

aggcataggc ctataataat tacggtcaca ctgggccata attgtattat aaggtcaagg    36720

gcagaggtaa ggggttattg aaggggagag actgtgtgtg gcttcccccc tctagagcag    36780

cggtgttagc taaaaatagc acatggggga tggagtggaa gcttcaggac tttctctggc    36840

aggttttctc ttttagccag acaccacaca gagttttctc ctttgtgtta ggcaacaaat    36900

aggatctcag catgtcttag gtgttgtctc cacgaagcac atagagagat ttccttcctg    36960

gacatagctt ccgtttataa ccttcagtag ctcaccaaat atggctcagc catgaggctc    37020

catgtggcag gaggctcagg aaatcctcag cactatgaat agggtctgta ctagggaggg    37080

ctcctgagca gatcctcagg cctgtgttgg tcaggaagtc aaagatcatg gactccatgg    37140

gctgctctga agcatagtgg ttttctacag ggtcaccctc tccaaacaga ggatgccatg    37200

tcactaactt agtagctgtt agcattacag catctgaata cattaataca agttggaaac    37260

gtaggataat aacaaatact gaatattctt tgtgcttaat aaagtactac atgtcataga    37320

aaacatattg aaaggcaaag gacttttaca gtatgaaggg acactcaaat gtgttacaaa    37380

atatatgaag atactaggag attaggtgag ctgcccagat tcccatggtt tcaagccata    37440

gaagctggca tttgtcttct agcctggggt ccttttcttc aggagacaga agaggcttcc    37500

acccaaatgc taaaaatatc agcccgaaga aaataaccac aacgttattt tatgtatact    37560

acatatttta tgtataccac actattgctg tcttcagaca caccagaaaa gggcaatgat    37620

tccattacag atggttgtga gccaccatgt ggttgctggg aattgaactc aggacccctg    37680

gaaaagcaat cagtgctttt aactgctgag ccatctctcc agcccctgtc atctggtttt    37740

tactgtcagg atttggtaaa cacaacttga cgagctcctt gctctccacc accatggagt    37800

tcctttgcat tgggttaagg catcagcaat aaccacccag agactgcact gtatcctgtg    37860

tgaagggcag gtcctcaact gttagccaag aaacacagat gagctgagaa ggccaccaaa    37920

agattcccaa ggtgatagag agacatccta agacatgacc cttgagtgaa ctgagagtca    37980

taaaactcta gtctccacga tggcacagat ggcatctgcc ctgaagctca tctgtatggt    38040

cagggacact gataggccgt gatgacagcc atgatgtaca cagagggtat tcagcaggtc    38100

caggcctact gaccatgcag ctcatgagga gccaagcaat ggaaggagcc tatgcttgcc    38160

tgaggggctg agcagcaatc cagcttcttc ctgagcactt ggacatagcc agtgtctgag    38220

ctgcagcatc aacccctgga ttgggcttgt gttttccaga cttcagacaa agtttaccaa    38280

atgaagaaca aacctcgggg atactgtctg atcatcaaca atcatgattt cagcaaggcc    38340

cgggaagaca taacccaact ccgaaaaatg aaggacagaa aaggaacaga ctgtgataaa    38400

ggtatggtgg gatccaaagg agaagcatga gaaaatttta ttcttatgga cctttcttta    38460

accaaaaagg agagagcagt agttatactt aaagggatat atatatatat atatatatat    38520

atatatataa attaattaaa gcatttatta tgttgaaaat ttttaaacaa tttttattag    38580

atattttctt catttacatt tcaaatgcta tccagaaaat ccccaatacc cttcccccgc    38640

cctgctcccc aacccaccca ttcccacttc ctgcccctgg cattacccta tactggggaa    38700

tataatcttt gcaagaccag gggcctctcc tcccaatgat ggccgactag gccatcttct    38760

gatacatatg cagctagaga catgagctca gggtgtactg gttaattcat attattgttc    38820

ctcctatagg gttgcagacc ccttcagcaa cttgggtact ttctctagct cttccattgg    38880

ggtccctgtg ttccatccaa tagctgactg tgagcatcca cttctgtgtt tgccaggcac    38940

cggcatagcc tcataagaga cagctatatc agggtccttt ccgcaaaatc ttgctggcat    39000

atacaatagt gtctgcgttt ggtggctgat tatgggatgg atcctcaggt ggggcagtct    39060

ctggacggtc tttccttcca tctcagctcc aaattttgtc tctgtaactc cttccatgga    39120

tgttttgttc cccattctaa ggatggacaa agtatccaca ctttggtctt ccttcttctt    39180

gagtttcatg tgttttccaa gttgtatctt tggtattcta agttttgggg ctaatatcca    39240

cttatcagtg agtgcatatc aagtgacttc ttttgtgatt gggttacctc acttaggatg    39300

atatcctcca gaaccatcca tttgcctaag aatttcataa attcattttt ttgatagctg    39360

agtagtactc cattgtgtaa atgtaccaca ttttccgtat ccattcctct attgagggac    39420

atctgggttc tttccagctt ctggctatta taaataaggc taccatgaac ataatggagc    39480

atatgttttt attaccagtt ggaacatctt ctgggtatat gcccaggaga ggtattgctt    39540

ggattctcct gtagtactat gttcaatttt ctgaagaacc gccagactga tttccagagt    39600

ggttgtacaa gcttgcaatc ccaccagcaa tggaggagtg ttcctctttc tccacatcct    39660

cgccagcatc tgctgtcacc tgaatttttg atcttagcca ttctgactgg tgtgaggtgg    39720

aatctcaggg ttgttttgat ttccatttcc ctgataatta aggatgttga acattttttc    39780

tggtgcttct cagccattcg tattcctcag ttgagaattc tttgtttagc tctgtgtccc    39840

attttttaat ggggttattg gattttctgg agtacagctt cttgagttct ttgtatatat    39900

tggatattag tcccctattg gatgtaggat tgggaaaaat cctttcccaa tctgttggcg    39960

gcctttttgt cttattgaca ggttcttttg ccttacagaa gctttgcaat tttatgaggt    40020

cccatttgtc gattctcaat cttacagcag actccatttc tgttctgttc aggaattttt    40080

tcccctgtgc ccatatcttt gaggctttcc cccactttct ccactataag ttttagtatc    40140

tctggtttta tgtggagttc cttgaaccac ttagacttga gctttgtaca aggagataag    40200

aatggatcaa tttgcattct tctatataat aaccgctagt taagccagca ccatttgttg    40260

aaaatgctgt cattttttcc actggatggt tttagctcct ttgtcaaaag atcaagtgac    40320

cataggtgtg tgggttcatt tctgggtctt caattctatt ctattgatct acctgtctgt    40380

agctgtacca gtaccatgca gtttttacca caattgcttt atagtacagc ttgaggtcag    40440

gcatggtgat tccaccagag gttcttttat tgttgagaag agtttttgct attctaggtt    40500

ttttgttatt ctagatgaat ttgcaaattg ccctttctaa ctcagtgaag aattgagttg    40560

gaattttgat ggggattgca ttgaatctgt agattgcatt tggcaaaata accattttta    40620

ctatattaat cctgccaatc catgagcatg ggagatcttt ccatcttctg agatcttctt    40680

ggatttcttt cttcagagac ttgaatttct tatcatacag atctttgact tccttagtta    40740

gagtcacacc aaggcatttt atattatttg tgactattgt gaagggtgtt gtttccctaa    40800

tttctttctc agcctgttta tcctctgtgt agagaaaggc cactgatttg ttttgagtta    40860

attttatatc cagctactgc actgaagctg tttatcaggt ttaggagttc tctggtggaa    40920

tttttagggt tacttatata tactatcata tcatctgcaa atagtgatat tttgacttct    40980

tcctttccaa tgtgtattcc cttgatctcc ttttgttgtc taattgctct ggctagaact    41040

tcaagtgcta tattgaatag gtagggaaaa agagtgcagg cttgtctagt ccctgatttt    41100

agtgggattg cttcaagttt ctctccattt agtttgatgt tggctactgg tttactgtat    41160

attgctttta ttatgtttag gtatgggcct tgaattcctg atctttccaa gacttttatc    41220

atgaacggac gttggatttt gtcaaatgct ttctcagcat ctaatgagat gatcatgtgg    41280

tttttgtctt tgagtttgtt tatatagtga attacgttga cgggtttcca tatattaaac    41340

cattcctgca tccctgggat gaaacctact tgatcatgat ggatgatcgt attgatgtgt    41400

tcttggattc ggtttgtgag aattttattg agtaattttg catggatatt cataaggaaa    41460

attggtctga agttctcttt ctttgttgga tctttatgtg gtttaggtat cagagtaatt    41520

gtggcttcat agaatgaatt gggtagagtg ccttctgttt ctattttgtg gaatagtttg    41580

aggagaattg gaattaggtc ttctttgaag gtctggtaga actctgcact aaacccatct    41640

ggtcctgggg tttttgttgt tgggagacta ttaatgacgg cttttatttc tttacggggg    41700

atatgggact gtttagatcg ttaatctgat cctgatttaa ctttggtacc tggtacctgt    41760

ctagaaaatt gtccatttca tccaggcttt ccagttttgt tgagtatagc cttttgttgt    41820

aggatctgat gatattttgg atttcctcag gttctgttgt catgtctcct ttttcgtttc    41880

tgattttgtt aattaggata ctgtccctgt gccctctagt tagtctggct aagggtttat    41940

ctatcttgtt gtttttctca aagaaccaac tcctggtttg gttgattctt tgtatagttc    42000

ttttcatttc cacttggttg atttcagccc taagtttgat tatttcctgc cgtctactcc    42060

tcttgggtga atttgcttcc tttttttcta gagcttttag gtgtgttgtc aagctgctag    42120

tgtgtgctct ctctagtttc tttttggagg ccctcagggc tatgagtttt cctcttaaga    42180

ctgctttcat tatgtcccat aagtttgagt atgttgtggc ttcattttca ttaaactctt    42240

tgatttcatt ctttatttct tccttgacca aggtatcatt gagtggagtg ttcttcagct    42300

tccacgtgaa tgttggcttt ctattattta attgaagatg atatttcatt ttttaagaca    42360

gggtttctct gtgtagccct ggctgtcctg aaactcactc tgtagaccag gctggcctcg    42420

aactcagaaa tctgcctgcc tctgcctccc aagtgctggg attaaaggtg tgcgccacta    42480

ctgcctggct aacttgtctg tttttatacc aatactgagg tcagagatga tgatacctcc    42540

agaagttctt ttattgttca ggattgtttt ggctattctg aggtttgttt gttttttcca    42600

catgaagttg atgattgctc tttcaaagtc tataaataat tgtgatggaa ttttgatgag    42660

gaatgcactg aatctgtaca ttgcttttag taagatggcc atttttacta tgttaatcct    42720

atcaatccat aagcttgagt gatctttcca tcatctaata tcatcttcaa ttcttctttt    42780

attcagagac ttgatgttct tatcacacag gtctttcact ggcttgctta gagttacacc    42840

aagatatttt atattgtttg tggctattgt gaaggatgtt gtttccctac tttttttctc    42900

agccccttta ttgtttgtgt aaaagagggc tagtgatttt ttttttttga gttaatttgg    42960

tatccaagat ttgaggtgtt tatcagctgt aggagttctc tgacagattt ggggggaggg    43020

tcacttatgt atacgatcat atcatctgtg tgtagcttta ctttgacttt tttagttgtc    43080

ttattgctct agctagaact ttactattga tagatatgga gagagtagat agccctgttt    43140

tgtccttgat tttagtggaa ttactttaag tttctcttaa tttaatttaa atttgggttg    43200

actatcagct tgctgtaaat tgcctttatt atgcttaggt acgtaccttg tatccctttt    43260

atcatgaagg tatgttggat tttgtcaagg ctttttcagc atctaatgaa atgatcatgt    43320

ggttttagtt ttaattttaa gtttgtttat ggtagattcc attgatggat ttccaaatgt    43380

tgatccctgc atccctgaga tgaagtatac ttgaccatag tggataatct ttatgatgtg    43440

ttcttagatt tggtttgtga gtattttatt gaatattttt gcatcaatgt tcataaggga    43500

aattggtctg aaattctgtt tctttgttga gtctttgtgt ggtttctgtg ttaaagtgac    43560

tgggacttca taaaatgaat ttgacaatgt ttcttctgtt tctattttgt ggaataattt    43620

gaggagtgct acctcaaatt attacctctt ctttgaaagt caagtagaat tctgtgctaa    43680

aacaatctgg ctctgggctt tctttggttg ggaaactttt aatgaccgct tctatttcct    43740

taggagttat aggactattt aaattgttta cctgatcttg attcaacttt ggttaagtag    43800

aatctatcaa gaaaatcatc catgtccctt aaattttcca attttgtgga gtacaggctt    43860

tagattcttt acatttcccc agtgtctgtt gttatgtccc ccttttcatt tctgagtctg    43920

ttaatttggg tactgtttct ctgcctttta gtcagtttag ttaagggttt tttctatctt    43980

gctgatgttc ttaagaaacc agctcttggt tttgttgatt ctttgtatag ttctctttgt    44040

ttctgattta tcgattttag ccccaagttt aatttttcct accattaact cctcttgggt    44100

gtgtttgctc ctttttgttc tagaactttt aggtgtgctt ttgaattgct agactgagat    44160

ctctccaatt tctttatcaa gacacttagc actatgaaag ttcctcttag cattgctttc    44220

atggttccat aagtttgggt atgttgtgtc atcattttca ttgaattcta gaaagtcttt    44280

atttttttcc ctgatccagt tgtcattgag tagagggagt tgttcggttt ccaggagttt    44340

gtagtctttc tgctgtttct gtagttgaag ttctgcttta atctatggtg gtctgataag    44400

aaacaaagca ttgtttcaat tttgttgtat ctgttttggc ttggtttgtg accaatatac    44460

ggtcaatttt ggagaaggtt ccatgaggtg ctgaggagga ggtaatcttt tgtgtttgtg    44520

tgaaatgttc tatagatctg taacacctat ttgatttata atgtctgtta gttttactat    44580

ttctctgttt tgtttctgtc tctatgatct gtccatggtg acagtgaggt gttgaagtct    44640

cccactatta tgtggggttt ggtgtgtgat ttaagcttta gtaaagtttc ttttatgaat    44700

gtgggttttc ttgaatttgg ggcatagatg ttcagaattg aggcatcatc ttggtacatt    44760

tttcctttga ggaacataaa gtgtccttcc ccatctcttt tgattatttt tggttgaaag    44820

tctattctat tagatattag aatggctacc ccaggttgct tcttaggtct gtttacttgg    44880

aaagtctttg tccagccctt tactctgaga taatgtcaac ctttgttgtt gaggtgtgtt    44940

tcttctgtgc agaataatga tggatcctat tttttcatcc attcagttag cctgaatctt    45000

ttttattagg gaattgagtc cattgatgtt gagagatatt aatgaccaat gattgttaat    45060

tcctgttatt ttgatggtgg tggtagtagt gtgtgtgtgt gtatgtgtgt gtgtagtatt    45120

tcccttcttt tggttttgct gatgtgatat ttatttcatg ttttcatggg tgtagttaat    45180

cttcttgggt tggagttttc cttctactag ggataaattt gtggacagat atggttttgt    45240

catagaatat tttgttttct ccattggtgg tgattgacgg ttttgctggg tatagtagtc    45300

tgggctgaca tctgttgtct cttaggatct gcaagatatc ttcccaggcc cttctggctt    45360

ttgagaagtc atgtgtattg cctttgtatg caacatggcc ttttcccctt gcagttttta    45420

atgttctttc tttgttccaa tatttagtgt cttcattatt atgtggagga aggattttct    45480

tttctgatcc aatttatttt gtattctgta ggcttcttgt ttgtttatag ctatgtcttt    45540

ctctaggttg ggaaagtttt cctgtatgat tttattgaaa atattttctg ggacttggag    45600

ttgggaatct tctccttcta gtcctgttat ttttggtttg atctttttct aattttccag    45660

atttcttgga tattttgtgt caggaacttt ttagatttag cattttattt ggttgatata    45720

tccatttcct caatagtatc ttccatgact gagattctgt cttccatttc atattctgtc    45780

agctatagtt cctcttctct tccatctcca agattccctg tttgtctttt ctatattgct    45840

actatttcca ttttcatgtc ttgtacagtt ttttttcatt tctttcacct gtttgattgt    45900

actttgtttt gattgtattt tcctatattt cttaatttcc tgtttaaagg cctctatcat    45960

ctttattaga ttgaatttaa ggtcatcttc ctgtgcttta gctgtgctag gatatttagg    46020

gcttggtgtg gtccaatagc tgggctctgg tggtgccata ttgccctggc tcttgctggt    46080

tgtattcgta tctggccttt agcacatggt tgtccctggt gtttgctgga tgttcctgtc    46140

actgacagta ctcctcaggg aggcaggcag agccttgggt ctgacaagag agctcaggaa    46200

acagcaagct gctcacctct gctgactgta cctcaggtgg ccctaagtgt tcctggagtc    46260

tagcaggcct ccttctaggg aagggaggca gagccatggg cttgccaatg tcacagagca    46320

aagcttgtct gtagttgtgc cccaggtgga atcagcagtc agaggatagg tgaggtaggg    46380

tctaatctgg gtgttcctgg ggacctacat gcctggatgt tcctgaggct gggcaggtct    46440

cctggagagg aaaggccatg gtgctggggg caggggaata ggaggagtgg acacagcatg    46500

cagctcacct ctctatcaag catttcttat tcattttatt tatttatatt tcttacatat    46560

ctattttctg ctgtttcaaa aaataggttt taaaatcaaa gtaatatatt catcatgata    46620

aaatgatagc tttctttttt tgtttttgtt ttttatttta cttgtaattc atttttttac    46680

actccatatt ccattcccgg cctctcccca tccaccctct gactgctcca catcacacac    46740

ctcctcccca ccccacccca tctccacatt ccccagctca tctgacctct atactctctg    46800

gggcatctag tctcttgagg gttagatgca tcatctgtga atgaacacag acctgaaagt    46860

cctctactct atgtgtgttg agggcctcat atcagctggt gtatgctgtc tgattgctgg    46920

tccaatgttt gaaagatctc atgggtccag attaattaag gctgctggtc ctcctacaga    46980

attgcccttc tcctcagctt cttttagcct tccctaattc aacaacaggg gccaactgct    47040

tctgcccatt gattgactgc aaatatctgc atctgactct ttcagctgct tgttgggtct    47100

ttcagagggc agtcacgata ggtccctttt tgtgagtatt ctatagcctt agtaataggg    47160

tcaggccttg ggacctccat ttgagctgaa aatgatagcc ttctaacatt tataatgaag    47220

agcatcaatg aactttaaaa tttttttaaa ttttatttca tatatatata tatatatata    47280

tatatatttc tatgtatgcc cctttgtgtg tgtgcatatg tgtgtgtgta tacttgtgtg    47340

tgtgtgtgtg tgtgtgtgtg tgtatgtttg tgtgtgcgag ggcctttgga tccagaacag    47400

gacaagttct atgcaagagc agcaaggact cttaaccact gagcaatctc tctagccctg    47460

agctttacat ttaactcaac taaatgaaaa atatttctgg agaatgaatt agtcaaaacc    47520

aattgctatg gtatcctact tactctgggt agtttgctca tgaaagtttc tcaattgcag    47580

caggagttgt gagctcccag caagatgcta aactagtgag acctgccttg gggcagccta    47640

cttatgttta tactgagagc tgacaagtta aatggaacaa tattcattta taagtataca    47700

atatacctat aacaagtata agaatacaga aatgggtgcc gggcatggtg gcgcacacct    47760

ttaatcccag cactcgggag gcagaggcag gtagatttct gagttcgagg ccagcctggt    47820

ctacaaagtg agttccagga cagccagggc tacacagaga aaccctgtct tgaaaaaaaa    47880

aaaaaagata cagaaatggg gctcaaagat ggctcaagag cactgactgc tcttccagag    47940

gtcctgagtt caattcccag gaaccacatg gtggcttaca accatctgta atgagatcct    48000

gtgccttctt cccgtatgtc tgaagacagc tactgtgttc tcatatacat aaaataattc    48060

ctaccaattc ttaccaagaa ttctttctcc tctcaatgtc ccaccttctc tttcctgcct    48120

aagccatagg ccataggctt tttaattgac aggtagtgca tccatacaat gcacataaga    48180

tgctctctct gcaggtgact cagtagttaa aagcactgac tgcttgttct gaggcttcag    48240

attcaattcc cagcacccac atggcagctc tcatgctgcc tgtatctcca gttccagagg    48300

agtcactctc ttcttctggc acgcacatac atgcgataaa agcactcgta cacacaaaat    48360

gataatgtaa agcatttaaa atacatggac aacaataaac atatgcaagg ttaagactca    48420

ggaagtcaga ccaaaagaaa acactgatgg aaaatgggaa caataggagt tgaaatggag    48480

aatactggtc acagatgcca gatctgtgac catgagagcc ataagacaaa gacaaggaaa    48540

tggacctgtg caagaagtga gtgtacgttc tccagtctga aagcgcttgt tgcatctttg    48600

agattgagag ggaggggtat ggacaagtca gatacgtaga gcagtcacag atcaggatat    48660

cactgaattt cataatagca gatctggaag ctaaaagatg aaaattcaga ggaaagggga    48720

ttttggaacg aatgctatat ctagctagac tgtcaaaaag aatgagagta gaaatgaatc    48780

ctcatggtgc aagaactcag caaagttcca gctggcagta cacagcactt tcagcaggca    48840

acaataaaca taaggagcct gtacaatccg attggtggtg atgcagaagg accgctcagg    48900

ttctggttct tgcctacagg ctgtgttctg ggaatgattg taattcatgg tttcccatct    48960

tacttttcag aggctctgag taagaccttt aaggagcttc attttgagat agtatcttac    49020

gacgactgca ctgcaaatga aatccacgag attctagaag gctaccaaag cgcagaccac    49080

aagaacaaag actgcttcat ctgctgtatc ctatcccacg gtgacaaggg tgtcgtctat    49140

ggaacggatg ggaaggaggc ctccatctat gacctgacat cttacttcac tggttcaaag    49200

tgcccttccc tgtctgggaa acccaagatc tttttcattc aggcttgcca aggaagtaac    49260

ttccagaaag gagtgcctga tgaggcaggc ttcgagcaac agaaccacac tttagaagtg    49320

gattcatcat ctcacaagaa ctatattccg gatgaggcag actttctgct gggaatggct    49380

acggtgaaga actgcgtttc ctaccgagat cctgtgaatg gaacctggta tattcagtca    49440

ctttgccaga gcctgaggga aagatgtcct cagtaagttt ggcctcctgg gcccctctca    49500

gggttatgct tccttactca tttctgtggt tagagcccat tagaaggtgc tttatggccg    49560

agataatata tactaagcag agaagtagcc attggcatgt tccatctctg aatgtctagc    49620

tgtagctgac acagttgtat ttcccaggtc agtggcaaag tgggagagat ggcacgtatt    49680

gttctcctta gttcatagat gggaaaagaa tatgtttact gaagagtttc ctttatttag    49740

caaccgaggt accacagagc cagagaggtt gctaatacca cacagtccag ctctgtcttt    49800

gggtagtaac tgactaaggc aactcaaccc ctttggggag tcttcccaga tggaagcaaa    49860

ccactatgtt taacatacct cacctttgtc agaagccatg ttttagagct ggcaagatgg    49920

ctcactgggt aaaggcactt ggttataagt cttataacat gaattagatc cccagaggcc    49980

tatatggtgg agaagaccaa ctccttcaaa ttgtcctatg accaccaaat gtgaaccatg    50040

tcatgtgcct gtgtgaataa gtaaatgtaa tttttaaaag ttaagaaaga aatcctctcc    50100

aattgctatc tagccttgaa tcttcttagc aaactataac cgtactgaag agcaggggac    50160

ctctatatct ctactaattt gacctgctag gaatccacaa gtgtgggatg atagccctgt    50220

ggcatatggt tcatctccag ttaaattagg gctccatact tcaggttccc tcccacttac    50280

acctggctga tagctgaaca atgaggagcc cttctacggg ctccttttac atctctgtct    50340

tatcgtctgg tgtctgaaga gtgagaattt cccatggcat gtggagagta gacaggaaca    50400

ccatcgcagt gctttcattt tgtaacacag accctgagtc ctacaggatc catgtcagct    50460

atgcagattg atgaagaggt tgctccacaa gattgctcag actgctggtg tcagagatgg    50520

ggaggtagct acgggaaatg cttagccttt acttgcctac attttagtag aaatctgtgg    50580

atgatcctgt aggagcaatg ctgatttagg cagagggtac tgggggaaga gagggaggca    50640

tttgtgagat ccaaatggca acatgggaaa catggaggaa cacataggtt aacagagaag    50700

gaaagcaaat ctgataggaa ctctggtttc ttgtaaccag cagagattcc aagtacacaa    50760

aagtaactct gtgtgctctg agaaaactga gttgccagaa cagcggtgag aggtcttgat    50820

tcagtgactt tcaactgcaa atgtccgatg ctctctctga gagacagaac tagagaacct    50880

acctcaggca cagccagtga ggtggtgggc acagccagtg agacagtggg cactgccagt    50940

gagatgtggg tggcacagcc agtgagacag tgagcacagc cagtgagagg gtgggcacag    51000

ccagtgagac agtgggcact gccaatgaga cgtgggtggc acagccagtg agacagtgag    51060

cacagccaga gagagggtgg acacagccag tgagacagtg ggcactacca gtgagacagt    51120

ggatatagcc agtgagacag tgagcacagc cagtgatacg gtgggcactg ccagtgagac    51180

ggtgggcaca gccagtgaga cggtggacac tgccttgtcc catatgctta cgctgctttc    51240

tttttcagag gagatgacat tcttagcatc ctgactggcg tgaactatga cgtgagcaat    51300

aaagacgaca ggaggaacaa gggaaagcag atgccacagc ccaccttcac actacggaag    51360

aagctcttct tccctcccta atgatgtgtg ctctccacag ttcacatggc ttatctgtgc    51420

acttttgtgt ggatgagtct aatttatttt ttagaatttc ttttgctttt gaatttacat    51480

ttacataatt ttcccttttc ttccctttaa acccttcttt gttatgttcc aatttcaaat    51540

acatggcctc ttttctcatt aactgttgta cacacacata catacacaca cacacacaca    51600

cacacacatt tctaaatata acctgtatac tatcacttgt atgtatgttt tgttttgctt    51660

tttttaaaaa atggagcgac ctttggtagg ccaatcacac tccaaggcag gtccctctcc    51720

caagaatagt tgggcaatac aaattggctt ccatgggttc acctttaatc tcagcactct    51780

ggagacagag gcaggaggat ctctgagttc aaagccaacc tgctctacat agcaagttct    51840

gagatagcca gggctacaca gagaaagctt gtcttgaaaa aaacaaaaaa gaaaacttga    51900

agatgcatga gtaagaaagc aagactggag catgaatctg gttaacagaa tgggtgaatg    51960

acgggagcag ggacctgggg caagttaaca gagggggtga atgacgggag cagggacctg    52020

gggcaagtta actgctgaag gtgagtcagc agaatggggt gaatatcatc agcattctct    52080

gcatgaaatt ctcagaggta ataataatat taaacttttt tctgtgcagt               52130


<210>  16
<211>  1053
<212>  DNA
<213>  Anopheles gambiae


<220>
<221>  misc_feature
<223>  mosquito gene Cyclin A (AGAP012413)

<400>  16
cgtagcgctc ctttgcaaga gctaaaacat gcagaactgc tcgaaactcc catgtcagtg       60

ggagaaaact tttctccaat gtcaatagac aagtcgacta gcataattgt cgaagaagga      120

cccatcccta ggaacgatcg cgagcgtttc ttcgaggtag aggagtacca ggaagacata      180

ctactttatc ttaaagaagc cgaaaagcgc aatcgtccga agccgggata tatgcttaaa      240

cagactgaca taacccattc tatgcgcaca attctggtcg attggttggt ggaggtttcc      300

gaagaataca aactgcaggg agaaacactt gcccttgccg tatcttacat cgatcgattc      360

cttagcttca tgtcggtagt tcgtgccaag cttcagttgg taggcacagc cgccatgttt      420

atcgcagcca agtacgaaga aatctatcca ccggacgtga gcgagtttgt ttacataaca      480

gatgatacgt acaccaagac ccaagtgttg cgaatggagc agctcatact gaaggttctt      540

tcatttgatt tgacggtacc aacttcgttg gtatttacta atacctactg tgtgatgaac      600

gacgtacccg ataaagttaa atatttaaca atgtatcttt gcgagttgtc attgctggaa      660

gcagatccat tcctaacgta tatgccatcc aaaattgcag ccggtgcttt ggcattagca      720

agacgcactc tcgatttacc gatgtggtcg aagatgttag agaataatac tggttacaaa      780

ttggtcgaca tgagagacat aattttagat ctaaacaaaa ctcatgttga tgcagtaaca      840

atgcaacaac aagcaataca ggaaaaatac aaatccaaaa cataccatga agtcgcatcc      900

ttacctgcta ctgagataac aaaagaatct tttgataaga tatgcgctac attatgcaat      960

tcttctgctg caacactgct actttctaac accgacagtg agttgttgaa ggaaatgggg     1020

cgagaaaatc catcaaactt acttttcgtt tag                                  1053


<210>  17
<211>  1110
<212>  DNA
<213>  Anopheles gambiae


<220>
<221>  misc_feature
<223>  mosquito gene inhibitor of apoptosis 1 (AGAP007294-PA)

<400>  17
atggcccatg cactatcgct acccgcccca ccgatcgacc tgcccgacaa caagcacaag       60

gatgacgatc tcgcctgcat gtcaccggag tacttccaca tcgaggagaa ccggttacgc      120

agcttcacct cccgctggcc ggtcacgttc atcagcccga acgtgctggc ccggtacggg      180

ttttactacg tcggcaccga tgacacggtc aagtgttact tctgccgggt ggagatcggg      240

ctgtgggaac cgcaggacga cgtgatccag gagcatctgc gctggtcgcc gtactgtccg      300

ctgctgaaga agcgccccac caacaacgtg ccgctgaacg cgaactatct cgatgccgtg      360

ccggagccga gcttcgacac ctgcggcatc agcgtgcggc acaattcgta cgcggagaat      420

gccgacgatc gggtgcggat agatttggac cggctgagcg gcgattcgtg gagcggggcg      480

agcgatatca gtctgagcag tgccgctggt gcagcggctg cttccgccgg ggagagcgag      540

ccgatgccgt cggtcgggag tggatacccg aactacgcga tcgaggcgga ccggctgaag      600

tcgtacgagg actggccgac gtcgctgaag cagaaaccgc agcagctgag cgacgctggc      660

ttcttctaca cgggcatgag cgaccgcgtc aagtgcttca gctgtggcgg tgggctgaag      720

gactgggagc aggaggacga cccgtggcag cagcacgcga tctggtacag caactgccac      780

tacctgcagc tgatgaaggg ccgcgagttc attcagaagt gcaacgagct gaaggaggcg      840

gcttccgcct cctccgctgc cagcacatct tccgcgatgt cttccgcctc gtcccagccg      900

tccactgacg agggcgagga cgatgcgggt ggcgatcggc gcgtaccgtc cgacggtaag      960

atctgcaaga tctgcttcgt caacgagtac aacaccgcgt tcatgccgtg cgggcacgtc     1020

gtcgcctgcg ccaagtgcgc atcgtccgtc agcaagtgtc cgctctgtca gcaaccgttc     1080

atcaacgtgc tacggctgta cctgtcgtaa                                      1110


<210>  18
<211>  2193
<212>  DNA
<213>  Anopheles gambiae


<220>
<221>  misc_feature
<223>  mosquito gene Glycerol-3-phosphate dehydrogenase (AGAP004437-PD)

<400>  18
atggcatcga gacttcgaaa gttcggcgtg acagcagccg gtatcgcgat cggtgccgcc       60

ctgtccacct atgccctgca gcacaaagat acgccccagt atcaggttca aatggaggaa      120

atgcaacgta ttcgacgtaa gcgaacgctg ccttcacgat cggaacagat caaggcgctg      180

cagagcgacg aagagtacga tgtgctgatc atcggtggtg gagccactgg ggccggttgt      240

gcactggatt cggtcacgcg cggacttaag accgccctgg tcgaagcgga cgactttgcc      300

agcggtacct cgtcacgatc aaccaagctg atccatggtg gtgtgcgata tctgcagaaa      360

gccattctcg gtttggacat tgaacagtac cggatggtaa aagaagctct gcacgagcgc      420

gcctcaatgc tgcgatcggc gccacatctg accagaccac tgccgatcat gcttcccgtt      480

tacacctggt ggcaaattcc gtacttctgg gtcggcatta aggcgtacga tttcgtcgct      540

ggcgatcgta acgtgaaaag ctcgtactat ctgtcacgcg ccgatgcgct ggaactgttt      600

cccatgttgc gcggcgataa actgtgcgga gctatcgtgt actacgacgg acagcaggat      660

gacgcacgta tgaatctggc catcgcactg accgcggcac gccatggcgc tgccatcacg      720

aatcacgtcg aggtgttgga gctgctgaag aaaaagggcg acgatggtaa ggatgtgctg      780

tgtggcgcca aggtccgtga taacattagc aaaaaggagt ggacgatcaa ggcaaagtgt      840

atcatcaacg cgaccggtcc gtttacggac tcgatccgca aaatggataa cccgacggtg      900

aaggaaatct gctgcccgag ctcgggcgtg catattgtgc tgccgggata ctacagccca      960

cagcagatgg gtctgctcga tccggacact tcggacggtc gcgttatctt cttcctgccc     1020

tggctgaacg gcacgatcgc cggtaccacg gactcgccgt gcgatgtaac gcgcaccccc     1080

acgcccaccg aggacgagat ccagtttatt ctgagcgaaa tcaagaacta tctcaacaag     1140

gacgttgatg ttcgccgtgg tgatgtgctg tcggcgtgga gtggcatccg accgctggtg     1200

tccgatccga acaaggagga cacgcaatcg ctggctcgca accacatcgt gcacgtgagc     1260

gactcgaagc tgatcacaat tgccggtggc aagtggacga cgttccgagc gatggccgag     1320

cacacgatcg atgctgccat caaggcgtgc aacctgaagc ccgagcgcgg ttgtgtcacc     1380

gatgggctgt ggattgaggg cgcccaggga tggacaccga cgatgtacat ccgcttggtg     1440

caggatttgg gtctggaggt agaggtggcc aaacatctgg ccatatcgta cggcgatcgt     1500

gcgtttgccg tggccaagct ggctacgctg actggcaagc gttggcccat catcggcaag     1560

aagctgcatc cggagttccc gtacattgat gcggaggtgc gctacggcat tcgcgagtat     1620

gcctgcactt gcgtggacat gatttcgcgc cgtttgcgac tgtcgttcct gaatgtgcag     1680

gccgccatcg aggcgctccc catgattgca gacatcatgg cggaggagct aaagtggtca     1740

aaggacgaaa aggagcgcca gataaagcag tgcgaacact tcctgcagac gcagatgggc     1800

caccaagcta accgcacact gaaggagaag gtaccgatca atctctccaa gcaggaggtc     1860

gacatgtacg tgaagcgctt cgaaacgatc gacaaggaga agaagggcta cgtgtcgatc     1920

accgacatta agcgcgcaat gaagtcgttc ggcgatgcgg aggtcagtgg cgaagagctg     1980

cacgacattc tcaaggaaat cgacaccaac atgaacggac aggtcgagct ggaggagtac     2040

ctacagatga tgtcggcaat caagtccgga tttgtatcgc actctcggtt tgctgcggtg     2100

gcggaacagg aagaaatccg caaggagcag gaacgtctca agaagcagat caccatcgag     2160

cgatctggag ccactcaacg aaagtcaaac taa                                  2193


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y forward primer

<400>  19
ggcagtgggt gtttcgtcct t                                                 21


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y reverse primer

<400>  20
aactgtttca tttcccctct cctc                                              24


<210>  21
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y-WT forward primer

<400>  21
ggtaaggaga taaagagttt ccgtac                                            26


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-M forward primer

<400>  22
acaccagcac caaagaggtg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-M reverse primer

<400>  23
gtaggtcagg gtggtcacga                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-WT forward primer

<400>  24
aagggagctg cagtggagta                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-WT reverse primer

<400>  25
ccgaaaatct gtgggaagtc                                                   20


<210>  26
<211>  2973
<212>  DNA
<213>  Gallus gallus


<220>
<221>  misc_feature
<223>  ATP5F1B

ACCESSION   NC_008465

<400>  26
gggcggagcg cggggctcag tcggcgccgc catgttgggg ctcgcgggtc gctgctccgc       60

cgccgccgcc tccgccgccc gcccggcgct gcgccgcgct gccgggccgt ctcatggctt      120

cctgccgctg ttactcagcc gcggggccgg cccggccgcc gccgtcggcg cgcgtgagtg      180

tggagcggcc gcggggtcac cttggggcct acgcgcgcgg ggggcgtcgc ggcgagcgcc      240

attctcgggc cccgttaaag cggaggggcc ctcagcgccc gccctgactc gctctctcct      300

tcaggccggg accacgcggc tcaggcggcc cccgccgcca aggccggctc cgccaccggg      360

cgcatcgtgg ccgtgatcgg cgcggtggtg gacgtgcagt tcgatgaggg gctgccgccc      420

atcctgaacg ccctggaggt gcagggccgg gagacgcgcc tggtgctgga ggtggcccag      480

catttgggtg agtggggagg ggggggcctg ggggggtcct ccggtgatga tggatatcgg      540

tgactttcgt tcttctgagc tcgctgaagc cacacgcgaa aatctgagga ggaggaggag      600

ggcaatgggt gctggggggc tgcgcgttgt ggggggctgc ggcccacagt ggctgtgctt      660

ggggctgcta tttccctgca ccgttttgtc cttgggggcc tctcccagca ccgcatcccc      720

ttggcagggg tgggaggaag cgtgcagctg tccccagggt cagcccgagg gcactgcggt      780

aactctgccc tcggcagggg agaacacggt gcgcaccatt gccatggatg gcacggaagg      840

gctggtgagg ggacagaagg tgttggactc cggcgctccc atccgcatcc ccgtcggccc      900

cgagaccttg ggaaggatca tgaatgtcat cggggaaccc atcgacgaga ggggccccat      960

cacaacgaaa cagtgagtga tgctgcaggc cgggccgtgg tgccgtgtgg ggtttggagg     1020

ctcggggtct ggcagcagtt gctgtccgta agggatccac tttggtcgct catttgcttc     1080

cctctggtgc tgtaggtttg ctgctatcca cgctgaagcc cctgagtttg tagagatgag     1140

cgtcgagcag gagatcctgg tgacgggcat caaggtggtg gacctgctgg ccccctatgc     1200

caagggtggc aagattggta cgtagccctc agagggaggg cggagcagag gcactgtgcc     1260

caccacgagg ctcagagccc atccccacac agcagcttcc ttcgctgatg agtaaccttt     1320

tgactttcgt tctactgagc ttgctgaagc aacgttcatt acctgaggag gaaaggggtg     1380

aagggagacc ccaggggggc tggattggct ccgggttgag tgggtcaccc ttttccccca     1440

ggtttgtttg gaggcgctgg cgtcggcaag acggtgctga tcatggaact gatcaacaac     1500

gtggcgaaag ctcacggcgg ttattcggtg ttcgctggtg tgggggagcg aacccgcgag     1560

ggcaacgatt tgtaccacga gatgattgaa tccggggtca tcaacctgaa agatgccacc     1620

tccaaggtgc gtgaggcccg ggctgggctg ggggcccgct ggcacggcag ctgtgctgat     1680

gttgggtctc tccttgtgcc aggtcgctct ggtctacgga cagatgaatg agcccccggg     1740

tgcccgtgcc agggtggctc tgactgggct gacggtggca gagtacttca gggaccagga     1800

aggccaggac gtgctgctct tcatcgacaa cattttccgc ttcacccagg ctggctcaga     1860

ggttggtgct gaccaccggg cagccagctg tcccagcatc aacagccctt catcaggccc     1920

atccccataa caatgctgct cttcatgtgg gctctgctgg ttgtctcacc gtctctgttc     1980

cctcctaggt gtcagccttg ctgggcagaa tcccctccgc cgtgggctac cagcccacac     2040

tggccactga catgggcacc atgcaggagc ggatcaccac cacacgcaaa ggctccatca     2100

cttcagtgca ggtagtgcca gtgctgtgcc tgctgggctg gggaccccca cagcgcccgc     2160

ctctgtccca tggtgcccac ccttcctgca ggccatctac gtgccagcag atgatctaac     2220

agaccctgcc cctgccacca ccttcgccca tttggatgcc accacggtgc tgtcccgtgc     2280

catcgctgag ctgggtatct accctgccgt ggaccctctg gattccacct ctcgaatcat     2340

ggaccccaac atcgtggggc ccgagcacta cgacgtggcc cgaggtgtgc agaagatcct     2400

tcaggtgagg tggggatggg gcagcgaccc ctggggatgc catggggtgc acgaagccct     2460

gactgctcac cgcctgcttt gtcccccccc ccgccaggac tacaagtccc tgcaggacat     2520

catcgccatc ctgggcatgg atgagctgtc tgaggaggac aagctgaccg tggcccgggc     2580

ccgcaagatc cagcgctttt tgtcacagcc cttccaggtg gccgaggtct tcaccggcca     2640

catgggcaag ctggtgcccc tgaaggagac catcaagggc ttcaagcaga tcctggcagg     2700

tgaggagggg gcacggggag ctgggggacc ccacgccggg cctggcacca cctcccccta     2760

ccgctggctg tgtttcctcc cctcaggtga atacgaccac ctcccagagc aggccttcta     2820

catggtgggg cccatcgagg aggcggtggc caaggcagag aagctggctg aggagcacgc     2880

gtgagcaggg ctgccttcac ccctcccggc tccgtgtggg gccggaccca aagtatttaa     2940

ggtttccaat aaaatgttgg tgaaaacagc ccg                                  2973


<210>  27
<211>  5358
<212>  DNA
<213>  Gallus gallus


<220>
<221>  misc_feature
<223>  cdc20 (cell division cycle 20)

Accession number: NC_006095

<400>  27
gtgaggctga gcggggacgc ggaggtgaga ggggctgcgg tggggctccg ggtcgggggg       60

gtgttgaggc ctgaaggccc cgtcgaggag ggggggcccg aggctcggcc taacgggagg      120

ggggcggccg tgcccggcgg tgccccgctg acccggcggg ccgcccgcag cgccatggcg      180

cacttcgtgt tcgaggcgga cctgcacggg ctgctgaagc tggacacgcc gatccccaac      240

gccccgcccg cgcggtggca gcgcaaggcc aaggagagcg cctgcccggg ccccggcccc      300

agccccgccg ccagcatgtc gcccatgaag ccggccaacc gctcgtacag cggcagcaag      360

acgccgtcca agactcccgg tgagcggagg cgcccagtgg cggggcgggg tgggagggcg      420

agcggggctg tgccgggccg ccctggccgg gtgggacgga gggcgtccct cgcttctggg      480

tgcgcggagc tccgcgctgg ggctgggaga accgccgccc ccaacccctc ggccgcccgc      540

gtgatgcggc tctgccggga cggcgtggga gggctgcgag cctcgtcagc ttcgtgcgct      600

gtaacagtgg gaaatggccc tcccttcttt gtgagccccg gcgctgtcgt tgcggcagaa      660

cctgggagtt atctgtttgg ccgttcccga tctgagctcg gcgcattcga tgcacggagg      720

tacgggggag gccgggaata gctgcgagct gcggctcgag cggcctgtgt gctcccaggc      780

ctgctgcggt catggagctt gtctgtgctg ggggctgaag tggtaaaatg cttcttggga      840

acggtgctag ttttgctttc caagcttgtt gaattcagac tcactcagta tctctaaaac      900

acactttata tatgtgaacg caggcaaatc tggatccaaa gtccagagca ccccaacaaa      960

agctggaggg gaccgctaca ttcccaaccg cagcactatg cagatggaaa tggccaattt     1020

cctcctaacc aaagaaaacg accctgctga aaattcccct accaagaagg tgagctttat     1080

ctcttactga gattaatctc tcactaagat tagtatgacg atcgttgcca aatacctaat     1140

ccttcatgac ctgtcagaga agcagacttt aaaagcaggc atggggatga gggctcctcc     1200

caactccact tccagtgctg ggccttcaga agcctgcaag tggaactggc gcacagcctg     1260

cacacgtggg cctgagcaca gctgctctgc agaggtatat ccttgagcac aggcttttac     1320

tttggcctgt gcagcttgtg atagcagaac ttgggctact gagactttga aatagagaag     1380

gttacggaga ccagagctgt gagcctgagc gctgtgaaac tgctggcagt agctgttcta     1440

ggacaatgtc tgcatgggga gcaattctgg aatgcgcaca caatgctctg aaatgtgttt     1500

atgaagcatt tggtcccttg tggctccagc tttctgcgct ggtgatgaga cgctgaattt     1560

gcctcttctc tgcaggaaaa tagcaccatg tcctgctgaa tcccacagcg caaccgaact     1620

atcttctacc agctttgttt aagggtggta tttcaaatga gtcttgatga gggtggtttg     1680

ttttcctagg agcaacagaa atcctgggca atgaatctta atggctttga tgtagaagag     1740

gctaagattc tccgccttag tggaaagcca cagaatgctc cagaaggtat gatgcagggt     1800

cagggtggtg cgtgcagggt ctgtttgagg gacttgggtg cagagatctg cgtggggaac     1860

tgcaacacac atggccctat ttctggccat gggagagatc agctggctgc atctgagttc     1920

tttgcacact gaaatctctc tcaggtttcc tgaagttcag gggttggcta aaagctggca     1980

tgttgtttgt gtgaggtttc tcattgtgct gttttatgag agttggatta tgactgccaa     2040

ttgcgaactt gtactgcaga taatgtattt ttctgaagtc tgcctatgaa agcttccaac     2100

tccctaagca aggaagtggg tagtagcaac agtcagttaa acgtgttctg gtgaactgga     2160

acccactctg attcagcaat actgccagtg atgctgtaac acagtgctct tctgcccaga     2220

tctcttttcc agggctttgt tctaactgga aggggttttc tagtgatatc ctgcttcctg     2280

accattcact caaagctgtt tctctgtgtg caggctatca gaacaacctg aaagtgctct     2340

acagccagaa gactacacct gcttccagta ggaagcatgg tagatacatt ccctcaatgc     2400

cagacaggat cctggatgca ccagagattc gcaatgacta ttgtaagtag gctgcggtgt     2460

tgggatcatt ttgcagcggg gtgaaatact taggcctgtg tggtctgatg aactgaaact     2520

cttaattggg ctgtttcagt tctcatgcac ccagactggc actgaccact tctggagtgt     2580

ctctgtgctg cctaatagtc caaggtacca tgcgggtgac ttgaactggg gctacttgac     2640

tgggcatggt gaatcccagg aggctgcccc ttacctgcat gcgcacatgg ctggtgcagg     2700

tgggaggtgt ggcatcatca cacagcactg cagtgaaata ttttcagtaa tgctgaagat     2760

gtgggtgagg ctccgcatgt aagcactgtg tgagctgcac tgctctttca aattgtagat     2820

ctgaatctca ttgactggag ctctcagaac ttcctggcag tggctctgga caactgtgtt     2880

tatctgtgga atcactctac tggggaaatc attcagctgc tgcagataga gaatccagat     2940

gattatgtat cctctgtgtc atggattaaa gaaggaaact accttgctgt tggtacaaga     3000

aatgctgagg tccaggtgag tgcagtaaga tgagaggtgt tgtccaagga ttgctggagc     3060

tgtggggcct tggaacaaag tcttggctag cacaggaaag atacagtgtt gtatctttca     3120

tacattctga cttgtcttaa gcacagggga gaggagtgtt ctaggacttg ttatagtcca     3180

gtgaattgct gcccactgtg ggagcagaag agtgaagtgg atgacttgtg acagaggcct     3240

gtagggaact tgtcactgct gtgcttctct gtcagagagc aagattgtct gaaggtgtcc     3300

ttatgctcac atcatcataa ggtagcacaa atcctaagta gtttgtaatc acagtaatcc     3360

ttgctgtggt cttgtgacta ttagtagtta cagtctctgt cttgtgatgc tgagggtgct     3420

aagactagca taagtggaag tgtccccatc cagctgtggt cagtgacaaa ctgcagtagt     3480

gaggcagact ttagggattt tctcatttct ggaataactt tgttctgtat gtgagaaatt     3540

aactgctgct cccatactga aaaggtcaaa tgccagagcc tatgtagtaa ggtttcctgg     3600

caaagcaaca atgctgttgg tccttaccct ctggagaaca taatactctt gcctctctag     3660

ctatgggatg tacagcagca gaagcgtctt cgaagtatga ccagccattc ttctcgtgtg     3720

gggtccctca gctggaacag ctacatcctc tccaggtaaa gctgggggtg aagcagtgtc     3780

cagctggaca cagtcagttg tgaagaggtt ctgtggctgc tctgctcatg tcaacaggcc     3840

agtgatggtg atcaacactg gttgaaaccc agtggcaaaa aaggcagcct tgcaatagca     3900

caaaaatggc ttttggtgaa aatgagctag tctgacactg tgaacctcct ctctgcagtg     3960

ggtcacgaac tggccacatc caccaccatg atgtcagagt ggctgagcac catgtggcca     4020

ctcttactgg ccacacacaa gaggtgtgcg gactcaagtg gtctctagat ggtcgctacc     4080

tggccagtgg tggcaatgac aacctggtga acatctggcc ctctgtccag ggagacagtg     4140

gagacttcac tcctgtacag accttcactc agcaccaggg tgctgtcaag gtgagtgcag     4200

gtctgctgtg tgtagtgtgg gagcatgtct gtgtgaaagg caggtgtgta gcacttgctg     4260

taaccctgcc ttgttggagg gagaatgccc tgaagctgct gtggcctgag ctctggaaga     4320

tgcaataggg gacaggttgc cttttgtact acttaaaatg aactgtttct tcctcaggct     4380

gtggcatggt gtccatggca gtcaaatgtt ctagccactg gaggtggaac cagtgacaga     4440

cacatccgca tctggaatgt ctgttccggc acctgtctca gtgctgttga tgcccactcc     4500

caggtgagac ataaacatcc tcgtgataaa ttctttctgg cacacatgat ggtgcctggg     4560

ccctgggaaa ggtcagggag ccagcagggg ctcatccttg ctgatgagta tcagcacaag     4620

tagcttgtgt cttcatggta tttctgcctc tttgcaggtc tgttctatcc tgtggtcaac     4680

aacctacaaa gagttcattt caggccatgg ctttgcgcag aatcagctag tgatatggaa     4740

gtatccaaca atggccaagg tcactgaact tcgaggtaag ctgagttctt tgtctgagga     4800

agagagggct gaaggcagat tcaagcctca gtttgagtag agactgctgc ttgtctaacc     4860

tgaagcacca ataataaaaa gatagtgtcc agggccatcc tccagaatac ttaagtgctc     4920

caagagtagg ccaaggatgt gacctcatga ggcttcagca tgttacaggg acaatgatgc     4980

aggctgttgt ggtttatgag ggacatacaa gtgtaaaagg tggggggaac catggttgtg     5040

tttagaatca gcacagccct gactgcatgc ttccttaggt cacactgccc gagtcctgaa     5100

cctgaccatg agcccagatg gtgtaacagt agcatcggca gctgctgatg aaacgctacg     5160

actttggcgc tgttttgaga tggatcccat aaagaagaag gaaaaagaga aggcaaacag     5220

tgccaaaagc agcatcattc accagggcat ccgataagtg cacagagttg gtgttgtggg     5280

aagctgggac atgggcttac acactgtaca gtattttaag tgttaataaa cagctttaat     5340

ttgcctttgc cttttaaa                                                   5358


<210>  28
<211>  12369
<212>  DNA
<213>  Gallus gallus


<220>
<221>  misc_feature
<223>  Casp8 (caspase 8) 

ACCESSION   NC_006094

<400>  28
aataacaatg tcctcgatta ggaatagctt ctggaatgga cttccagaag gaatttaaga       60

gaacttgcaa gagaatttgt ctgggtctgt gtagttcgtt gctgtcctgc aaggagacat      120

ctgacctaaa tttttcaaat gtgtaatgtg taatgagtct tctcaaactt gaattggtag      180

gtcttctaag gcaatggagg agtaaagact tgctttcctg tcctgctgaa gcaatgaaat      240

ctattcagcc ctggtcttaa gtgtgaggaa gcacctccaa ccagtatgat ttttaactgt      300

tatattacac tggaattatc atttctatct gttgagagag taagtccttg aaatctgaag      360

aaaagaacag gaagatccag agtgccagat cccttcccag ggaacttgtg taatagattt      420

acacaggact gagtgactgg gtatctctgg aaggtgtgta gtttttcaca gaaaataatg      480

tctctgtcta gaaggacaaa agaaaaatga ttgttatata tctggttctt ttccttcaca      540

tttttttgtt tgctttatgt tattaatttg catggttggg cagcattgct ggctaggatt      600

tttaataata agttccaatt gtgctctttc tcagagtgct ttggaagcat tatcttttga      660

aaggctgttg gccactggaa gtaaggtccc actccatgag actctcaatt ctgagatgct      720

gtcacctcct ggcaactggc tgtagcttct accggctcct aatctctatt gtaataaaca      780

ctgttggttg tcacatcacc cttgtttgtg gtgttttcct ctgaggagct gactgagggt      840

cagtcagcac aacaaacctc ctttgcttca tctgaagaag ttacttttgc tttcactgaa      900

gtattctatg gcagacaccc tgagggaggg gtggcgtgtt gatattcttt cattagcaga      960

tggagagatg gtagaaaaga gtaagcttaa agttaggaca ttcttgataa tgggagctga     1020

ttccagtgaa gctgttctta ccttgtatct tcagcgatac acatgtagta tctgggagcc     1080

atctggaatt ctaatggcta tatccatttt gagctttata acaagacaaa ggatcaatgt     1140

gcaacacttt ataacttctg ccttttttaa cttggatttt tttttttttt tttttttttt     1200

ttttgagatc tgtgtctagc tgtaatgcag gggttcttta ttcagtcctg tttgtcttcc     1260

tgaagtgagg cttttttact cctaattcct cacagtatgt tgacagttgc tctgcttacc     1320

attttcactt tccaagtaaa agagagaatg tctgttctta gaatcacagc tctgtgattc     1380

taaaaaccca aaaagtcaga aggatcgtga ggccccgctt tcacggtctg tatttgtact     1440

gaaaatcaag atcaagtgag ctttcaccct tctgcataca ggtttcgtaa ataatacatt     1500

gatattatga gcactatata aatgagaatg ctgtttgtgg cagatattag cagaaggtgt     1560

taggagttat gatgcatttc tatagctgat gtttggttaa ctgttgagga aacatgacaa     1620

ttcacgtttt tacagcattt tcataagtgc gaccttgcta taaatgtagt agttaatttt     1680

ttttttttta aattttatgg aaatatagtt tgaatgaaat tgctgcttcc tctgggagaa     1740

gcttgctgga aggtggcagc tgctccagta gaattaagag aaaatattac tggtattagt     1800

gaagtgatga atctacagca cttccgtttc tttctatgtc tccgtgtcag aattctgtcc     1860

tctcagacta ggttctttta tatactccac atgaggagaa tttaatgtct aatatcaatt     1920

ttacttgttt ggtgttactt gggttttttt atatagtaat aataaacata atattataaa     1980

ataggaggca tgacttttgg agaagccctt gtacttagaa gtaatttcag gaagaagtca     2040

tactgtgagt tgatacgtgg ctcaatgaag gagaaaatgc actttgattt tttgtggttc     2100

tgagcaaaat aaacactcac agccccatgg ctgagtgact gcgatgtttc tgaccatatt     2160

tgttgccctc taccagagct gagagttatg aaggaagctt gaaggctgta caatttcctg     2220

actgttagct tctaacagtc tgtgactgac tgactgtgct tctctgtagc acaacccggt     2280

gaaaggggag gggtaactgc ctctctgttc agaaggctat agttagtcat ctagttattc     2340

agcctgcctt tcccttttct tcaactcatg tctgggaggc agaacttttt gcactgaaac     2400

aatgctggca cttaagtctg ttctcagcca atggaagcgt taccagcggg aagtgaatca     2460

caagcttggc aggaaggcaa cgctaagtcc tgcagaggta acctagaaag caggcaaagt     2520

gacgctgttt gggaaagaaa atgctaagtg agggaggggc attatctgct taggcaggaa     2580

cagtgttcat tcagaggcac gaatgtctgc cctttgattt gcatcttctt ttcctatttg     2640

ttcagttgaa tgtcagttta acgtcagtgt cccacagaca tgttgatgcc agccttccct     2700

gggaaattta tcattctctc atttttaggg taacctggta atctgctgct gccggggtgg     2760

gttattggca agttttagga gcctgcctgc tcactgctgc tttctctcat tgcatgggct     2820

gctgtaagta tgtgcttttc cactacctct gtaagggttc actcttttca aagtttttaa     2880

agtgctgaaa agtttgatta caggggattt ttttatttaa ttacttactt atttatattt     2940

aactgttggc tgtgtctgtc gtctacaaca tctcacacag gaaatcgtgg aaactcatgg     3000

gaagtggaaa caaattccac atcctttaga agatccagtt gtgcagcatg gagtccagag     3060

ctagaacgtt ctcaggaatt tttcagtgtt gagtccttga tggccatcct ttttattttg     3120

acccctaact tacatgggca catgttctct ggaattattc agatctacct ttttctgcta     3180

aagaggtgta aacttacaga gaacatgttt actttacaac ggtttctgtg cagtgtacta     3240

aaatatagtt tagatctttg ggaatttcca agtactcatt tgtgtttcct ttctgaagct     3300

gtgcctttgc ttactgctgt atttgttcta tttttgacag ccatgggaat tccccagtca     3360

cataatgtga ctagcttttg cagttctcaa ctgtaataca ttcctagcta ggtacaaagt     3420

tatggcctgg gtcttttata tcagattttc ctgtagctac tttgttttta ggctgctttg     3480

tccagacatg tcagtgcaaa aagaataatc catacctcct gcagtctgtt cactaggagt     3540

ttgttttaaa aggacttgag gggatattaa ctcataagct gttaaaaaaa aaaaaaaaaa     3600

tgtctcacta cattcagatt acttccacct ttgacccaat ctatatgcag gcagtaacca     3660

aatatcttgc ttagggcttt gaacattggt gacttttatg ataataatgt aaatatttct     3720

gcttaattgc tgtgttaaag ggtatatatc caagttggca gattcttttg aataccaata     3780

atgtgaataa cacagctctg aactatgaaa tacccctaca gagatttctg tgtttcccag     3840

ggaagcccgt ggtgaaactg agtgtgaaaa tcttccccag taggtatccc tgtgggggcg     3900

ggaagagagg ctcagcccat tgactggttc cagaaatcag cagtgtcctc ctgacttgtc     3960

tgcgatagaa tctttcccaa aaattcctcc tccttttttt tttttttttt taatactatt     4020

ttcttacttt caagtggagc ttgagtgact aatattacct gtctttgtcg cgattggtgc     4080

aacagaaaac tgaaaaactg ctatctcagt ttgattgcta tgcagtttat cagttccaca     4140

gtaccaccaa gttcccatcc ctgtgcttag ggagctgtca tggaatacac tccatgcata     4200

tttactgcat tccaccctgg aggtttctac aacacttttc ttcttttgag aggagaatat     4260

ccctataagc aacttccggt aatcattcca cataatcgat cccatgacta cagttgctca     4320

agactcacaa tacttagaag gaactgggga gggcatgtgc agccttttta ttaggattag     4380

agttcaaggg gctctgaggc tgttcactat ttatagggta agatgattgg cacagtcata     4440

gtatgtagca gaactgtgtt atcagccctg aaaacagcct tgggtgtaac agccaggcca     4500

aaggaggaga ttgggggtgg ggggaagcac actctcagat tactgtctaa aaaaatgttg     4560

gttttttttt ttttttttga aagagagaag tagtaggaag aggttccgtt ttaaaaccag     4620

tgctgaggct gagcgcagat ctcctgccat ggtgtaaatg ttcggtttta gaaccatgaa     4680

actccaacaa gtaaaaacat ctccctcctt cctcctgttg ttatgaaata ccatctgtgt     4740

gttagaattt ataacagagg cgatgcacca tcccaaggtc tcaccccatc gtgccacttc     4800

ctgtgggctt gctcctcctg ctgaaagcct ccagcaaatc ccgagggctg ggaagggagt     4860

tggttccgtg acttgtgccc gttaataggg aaaagggtca aatacctgta ctgagcgtgc     4920

tgtgcttcct gtcggcagcc tgggggcagc ttgtgaggag gaagtggtgt tctgagattc     4980

tttcattagt attaaaatga tgatgaattg ttagtgccct cagactgtgg aggtgtgact     5040

gcagacagag cccaggcaga gggagagctc ctgacctgca aaaataagtt cagttttctc     5100

aagactcctt ttcatgccag aaatatcctt gggatgcatg tgaagataat ggcgcgattt     5160

gagctcaaac tcttattgga gaactctgaa gtcctcttgt ttactatgct taaccactga     5220

agtgccactc tggcaattga ttttcacgtg tctctgtgtg tgtttcttct gaagtacttc     5280

agcacagagg caaagctctt cctttggctt cccccacgtt tccacttact ggttttgctg     5340

agtgggtgaa tgaatcttat gaagcaaaag ggaagaattc aaaaaagcag tgggcagcgt     5400

ttatgtaaaa cagcacagaa tgctgtgttt tgcatgtaat acaagatcag ccacgtacgt     5460

aacattcact tcttcctgtc agtagtatgt gtgtttgaag tgatatgagg aatctctcct     5520

ccaggaaaag agcaccgatc tgctattgtt tttgtggggt ttttttttct tcttttttct     5580

tttttctttc tttctttctt cttctttttt ttgttttttt aacagtaaag agagatgtat     5640

cggtatttca cggtaagaga agaaaaggaa atatgaagta cagtgccgcc caggctgaag     5700

gaaagagctc agcatttgga cagcagtgac gcctgtggag ataggcgtag gggaggtggg     5760

cgctggtgag cgctgaccgg cccccgtgct ctcccccggg ccgtgccaag cgcacagcag     5820

ggattttcta cttcttcagt ctctattaaa aaaaaaaaaa aatagcgctc cgtaactgtg     5880

aacggagacg gcctcagctg tgtcagaaag ctcccgtctg gcaggcaagc agtttctgag     5940

ttgaagtggg agttttcaag tcaggaatcc agacggaact acagctccca ggagcctggg     6000

cgctgcctcg cctgtccgga ggcgggcgga agcgcagagg cgcgggtgca cgaggaagcg     6060

gcgcccatcc cggcccgggg ctggagctgc tgcggggcga tggagttctc gcagctgctc     6120

ttcgtgatca gcgaggcgct ggacaggact gagctggcgt ctctgaagtt tctcagcctg     6180

gagcacgtca ctgtaaggaa gcgggaagat attgaggagc ccaaggcctt cttccaagca     6240

ttacaggaga aagggatgat cgaggtgggg gacctgttct tcttgaagga gctgctctat     6300

cggatcaatc gaatagacct tctagcttcc tacctgggct ccagccgaga ggagatggag     6360

agagagctcc aggttccagg cagggcacgg gtgtctccgt tcaggtgagc ggctgacagt     6420

gtgggttcac cagggtcctg gaggcgaaag cctagcagag cctgaccctg gagttcctct     6480

ctggggatca gttatctttc ttgggtgggg aggtgcaaga tttttacaga tgagttaaca     6540

ccagggtaag atttggcaaa acacaagcat ctccatcttt ccaaggaaaa gtgggtataa     6600

gcagtagaga aagcttctgt ccagtaaagg agagaagacc aagctttctt ctctgtaaga     6660

gccatgagga actgtaatgg actgtccaga gaggtggttt agtcactgtg cctagaggtg     6720

ttcaagaaac ttgtggatgt ggtactaagg gacatgattt agtgggaaac tattggcagt     6780

aggtgggcag ttagactaca tgatcttaga gctcttttcc aaccttggcg attctatgat     6840

tctgagataa cacccgcctg ggtgttgtgg gctgcagtca gtgactgggt gtgactgtct     6900

ttgccctggt gtcccagtgc agaaactctc tgtgcaattc tgattttggg aaaacagata     6960

tttttagttg cagctgaaaa tggtttgact tctgtctgtt ctgggactga tgtcctcaat     7020

taaagagaaa aaaaaagctg ccctgggaag gcagctgagg ggatggttca atggtacagt     7080

gtaaaactgt gcgaaggaga atgctagaga acataatgaa gctgtcctcc actgttcctt     7140

ctaggtatct gctctttcag ctgtcagaaa acatcaccaa agatgacatg aagtgtttca     7200

agtttcttct ggggaaagaa ttaccaaaat gcaagctaag tcctgaaact gtaagaattg     7260

ttttgttctg ttttattttt cttttgtttt cttttacatc attgctataa tacatagcaa     7320

catttaggct gcattgaggg gaatgagtgt cgcttttcca taaggaaaag ggaggatctg     7380

gaatggtgca tagaggacat gttgcatgcc agtgttacgt gtagctccag cagtactgct     7440

ccagcccaga aagcacaggc cagccctgga ccaggcatga cgcctgcaga cccaagctgt     7500

gtatagggtt gactggcttt cttcagtagg aggctgagca ctgtcactca tcttttccag     7560

ctggttttct tttggctgct ttctaagtaa gtaattagca aatgaagaat cacccactag     7620

ggctattcct gtaatgtttt ggttctgttt atttccaaac gtagaagaaa accccaaaca     7680

gatctaggca gagatcctta ctagagctag ggcccaagag cttgaagtta acttacatca     7740

ttgcaagaga tccagctgct ctttacacta tgtcaacctg cccttttgac tgctaggtac     7800

tttgttctgc ctaatgaaat ctcttttaaa atcttccctc tgttcttaga ggataaactg     7860

tgcctgttca gtggtggctc ttctagtaaa tccatgggtg accactgtgc tctgcgactc     7920

tctttggcaa aagcttctgt cccttgggtt ctgtctttct tcagagaact ctttatacca     7980

tatttgcatg gttataccca tttttgctac agtgatgctt gtgtttcagt caagtgtaca     8040

aagttgccac tgcaagtcag ataaatgata ggagtcatta aaaatgacat tatttgttcc     8100

tgagtgatta ccattagttc tcctgggtta gatcttacta gctctcagca tctctgagca     8160

gtgggaggga aataagcttg ttttgggaaa atatttctag tcattgtatt tctagctttt     8220

gtcaacctac atttaattga atcagcttga ggtatcagct gagacagtga gactgacagt     8280

ggttcacttg tgttgtcaat acattaaaac cagctcggtt gctcctaaac atgctgcagc     8340

ttccttctca gtagcagcat ggatctgccc taagagcaaa ctacctttct gattgctcag     8400

acaatgccgg acgttttcat tgagatggag aagaagggga ttttgaaaga agacaactta     8460

actgtcctga agactatttg tgggaaagtg gacaagagcc tgttgaagaa aattgaagac     8520

tatgaattaa acttacttgg taaaacaaaa caaggcctct ttcccacact ttttatcctt     8580

gaagtgatgt ataaggtgtc ttacaggact aataatgaat gctttccagg tgaaggagag     8640

atgcttgtaa cagaggggca aagaagcagc acaggagccc ctgaaggtaa ctgaaactcc     8700

ttcgaaaatg aacgtttaga tcttttgctt ttttccagct tttggactct ctacactact     8760

tgcatcttgc ctctttaaac atgtgcctat ctgagaagtg atcaggtatc cttttgctta     8820

ctaactgatc acagcacttt aaactccctt ttaattgttt acttatacat atgttttgtg     8880

tgtgtattca gacagtgcca tttggctggc atcatctgtg gcacccgatt ctctgggcaa     8940

ctgtgatcag tcttcacagg taggtcagtt tgtgtcttag taatgtcaca attttgtctc     9000

agaagagacc attcatttat gaagtacaca tgaagtattg taagcacagc tgttaaaggc     9060

acggtctgga aaagcaaaga tgcactactc tgtaatgtcc tttattttga aactatgtac     9120

caggcagaag ctgcagcagc attaaaactt aagaaatgtt tttaagggta gaagataccc     9180

ctaactttta ataccaggag acaggcagat aaataggcac agagaagcgg gtgaatgcaa     9240

caccccttgt gggtggagtg tgatggtgga ggctgcaaga ggtgggttct tctgctgtga     9300

ggcagcacgt ggccaagtcc tgggagcaga gctgtacggg gagagctgcc cagatagaaa     9360

gctggctggc tttttaccct ctgtgccact acaaaggctg agaagcagtc acaagaagtc     9420

tttctttcca acagcttgaa gtttataaaa tgaccagccg accccgtgga gtctgcctga     9480

tcctgaataa tcacaatttt gcaaaagcca gggaagcagt gccagaactc agaaggatga     9540

aagatcggaa tgggacacat gtggatgcag gtacagtgaa tgttacagat gagtttacat     9600

gtattcaggg agagtggacc gtacataaaa acaggaagca ttttgtgttg tgtttcagac     9660

taggagtctg aagttcaagc ttccatttca aggctatgtt tcttgtagtg gtagacttgc     9720

atactactaa aatacacaga atcagaaaca gatttgctgg agaaccagaa ttttacttta     9780

tatctagcgt aagagtgggt ggggacctga cttcaggcag tattacaaag ggccctcact     9840

ttagcaggct gtcctgcaga agagcagcac agctcatgga aggtctgagg ggctgtgaaa     9900

tgggtttatt tgcactacat tgaccaggag agaaaaatcc atcatcagag tacaggttat     9960

cttcttgaga cgcaggtact acctgaatat attgacagaa atatttattt atataaataa    10020

atatagaatc gttatataat atatatttta attaatatat ataatataat tatatattat    10080

aataatataa aaataaaata aaattatatt atataaataa taaaattata ttacatataa    10140

tacataccat aataatatat attatatatt atttatatta tatataattt ataaattata    10200

gatattatat attttatatt atatgtaata tacaatataa atatatgtga tatatattat    10260

aatatacata tatacatata aatataatat aaatatatgt aatatatatt atatatgtag    10320

cattatacat atattatata taatatataa aatatatgat caaaacatgg aggtaaatgt    10380

cagtattttt agtttgtcat attttaatcg atgtactaac tttgttttta ttgaatgcgt    10440

gatcaagctg tcctagggga ggtttagata gatgttagga agaatttcat aagggtgtgg    10500

gtggtcaagc actggaatgg gctatccagg gaggtggtag agtatctacc cctggaggta    10560

tttaagagct gtgtggacat ggccctaagg tgcagaattt agtgatggga tgtggtaggt    10620

ctggttgata gttgaattct atgatcttga aggtcttttc caacctcgat gattctagga    10680

gaaatcactc ccacccatct agagttgaaa caactgttaa caaatagcaa atgccctcca    10740

ctcttgggga atggagtggc actgtttgac atgtgttgca agatgcagag aacagctgta    10800

aagttctgtg agagctaaca gctaagtctg cacttttccc ttgcagacaa tactgaacag    10860

caagatcaca aggaattctt ttaatgagag acaagggaat gtaatacaaa tatgactagt    10920

gatcagacaa ctagattatt ttcagagaaa gaatgtaaat acctggatag tagggtggcg    10980

ggattaaaaa aaaaaaaaaa aaaaaaaaaa ggtttatttg taagaagtgt ccaagtttta    11040

gaaaactgct ttaatccccc cttggtttac tttccagatg ctctgagaaa agtctttagc    11100

aaccttcatt ttacagtagc agaatacaaa gactgcactg cagaggaaat ccgtaacata    11160

gtgaacaact atcggtgcat ggaccacaac aacaaagact gttttgtttg ctgtattctc    11220

tctcatggaa aaaaaggcat tatatatggt gttgatgggc aggaagtacc tatccaagaa    11280

ctgaccactt ctttcactgg gcaaaattgc caatcacttg ctggaaaacc aaaagtcttc    11340

tttgttcagg cctgccaagg tgatgcttat cagaaaggtg taaccattga aacagattct    11400

ggggagcaag attattctct agaaacagat gcaagatttc agctggactg catcccctca    11460

gaggcagact tcctcttggg catggctacc ctgcaagatt atgtctccta cagaagccca    11520

agccagggga cctggtacat acagtcactg tgccaacact tggagagcag ctgtcctagg    11580

taattatact tcctaagata ctttttcgca acacctttat cttccttctg aaggacacaa    11640

gtttgatttg gatgcagagg tagataacct gcagggggag tgatcactca gtgaaaagag    11700

caatgtagaa tagcaacact gattgtttga agcagttcac ccaactgctt taaagacggt    11760

ttagaggagc cattagcact cgcacaggtc aagatgatat ataagaatgc agtaagtttt    11820

ctgatgttac atacaaatac tctatacaaa accgcttgta ttttttgcag aggagaagat    11880

attctcacca tactgacagc agtgaatcaa gaggtgagca gcaagattga caagcagaat    11940

gcagggaagc aaatgccaca gcccagtttc acactgagga aaaaactcat atttcctgta    12000

aactaaatgg gagcagaggc agagagcact gcagtaacct ggaaaccact catctcagct    12060

aaaaattcag taagacatca gtctgctctt agcacatatg caaatgtttt tattggtaac    12120

acataaggaa taaaggcttt acgaatataa gagttaatct gtgtgacgct ttttatactt    12180

ggaagtatct cagagctggt ctccagtttg caaccttaca atatatggag ggctcttcca    12240

gatgtactct atgctgttgt tgttgtttta agatactttt caaatacaaa ctcatataaa    12300

gccttgtgta ttttatgttt aacttttcat aaaataaaat gcaggggact gcaaatttta    12360

tagaacgca                                                            12369


<210>  29
<211>  1364
<212>  DNA
<213>  Anopheles gambiae


<220>
<221>  misc_feature
<223>  Yellow-g (AGAP005958)

<400>  29
cgcgtttgtt cttcgttgtg gatcacgggt ttgtgttggc gctggggata aacgaacgca       60

cagaacacga tgagttgccg cgtgacgggg ctaccgcttg ccctgctgtt tgtgctggtg      120

tccgcgctcg ctagcacgga cgatctcgag tactgcaaca tcgtgtaccg gatcaatggc      180

aattcgatcg actttccctg cctttcgacc aagaacatct acatctccgc acatcgctac      240

cagccacgca atgtgatgcc ggtgcggtgc cagtacgaca atcaacgcat gctgatggca      300

ctgccaagat tgcgctcggg cgttcctacc acgcttgggc agatcgatct gaacaaaccg      360

aactgctacg cgcacattaa gccgtaccct tgctgggcct atcaggagga gggcaattgc      420

aactcgctcc aatccgtcat cgatctgtac gtggatgtga aggtacgttg ttgtgttacc      480

gtggccaccg tgcttttgcg gtaggatgaa aacatgctaa cgtgtcgtct ctttccttgc      540

agcgcatcgc gtgggtgctg gactcgggca tcaccaactt cctggagcaa ccgatcaagc      600

gctgcccgcc gaaggtgtat gccttcaact tgagcaacga caagacggtc aagacgatcg      660

acctgtcgga gattgtgaaa tccagctcgc ggctccagta tctcgtcact gattacaacg      720

agctcggcca tccgtttgtg taagtattgt gttgggtaaa gcatgcaaag taaaatcacg      780

tgcgtgatgc taacgatctc ccaacttgca gctacatttc cgatggcgat ggtgcaatca      840

ttgtgctgga cgtgaacaac aacaagagct tccgcgtggt gctaccgcgt gccatctcgg      900

ctggctgcgg cgattcggac gtgctctacc tgctgctcat cccgaaaccg aagggccaga      960

gcctggtgat cttcagctat ctgtgcggcc agaaggttta ctcgatcaag tcggaacatc     1020

tgcgcagcgg caagggttcg agcgcgatcg tcgagctcgg caccaagcgc aaacactccg     1080

tcctgctcgg cacggacggt ggcaaggggg tggtgctgcg gtaccgtggc gaggccgagc     1140

tgtacctctg ggacagcgat cagccgtaca gggagtgtaa ctttgagctg attcagaacg     1200

cggacgagtg ccggctgtcg acgcacgtgg tcgtgggcaa gaacgagcat ctactgtcgc     1260

tgtcgtcgaa cttgagcgat tttctcaaca acacgtgcgg cgttggtggc gcctcgtccc     1320

ggttgaagta cgtttgcaag gagtgtgacg atgattgtta ctaa                      1364


<210>  30
<211>  8612
<212>  DNA
<213>  Anopheles gambiae


<220>
<221>  misc_feature
<223>  AGAP007280

<400>  30
atggcggatc acgatcaaac tgtgctagat ggtaagtgcc aacgacgcaa tgcgtgtcct       60

acatatggct gcatgttttt accaacgttt cgaaaacaaa ctgccaaagc aattgattta      120

aaaaaacaca ctcacacaca taaagctttc ttgtcctcaa ttgctcagga gacggtccac      180

acgcataagc acaaaaaaat gcataagaaa tctatacatt ttccctcccc tttgaacgat      240

ttactttgaa actttcaaca tacccccaaa atgtgtacaa gtaaacaaac ggactgcggt      300

ccgtccatcc accaggtgat atgaatgaaa agggagagag agagggcaac gggtggggag      360

gtttgggcag gctcggctca aaagtttgtc aacagtgcgt ccaattactc gtacgtaagc      420

ggaactatca tcggacccgc gcctgtcccg gtgtataaac aattattggg ctttttaaac      480

cgattgacat aacataacct agttcgggtg gaggattgga ggtcgtgcac gaaacggggt      540

cttaccttct tggctttcct tcctttccaa cacggcagaa gagttggcaa cgatcaactc      600

gacgagaatg cagcaattgg tgggtgctgg caggacgaac tggctctgcc tgatgatgac      660

ggcgatcggt ggagtgatcg tgatggctgc gatcgcgttc ggtttctacc taaccatacc      720

cgcatcaggt acgtgatagt agatcaagag gtgagcgact cgtatgtcat ttttaataca      780

ccttcctcct gttagctctc tcccaacaac catctaacct gattgagcta gaacctatcg      840

aagtacaaag ccccgaagag ctggaaacca tccgcgaaac gtacttcaaa gcggaagcac      900

atgacatcct gatgggatca ctggaattgc tggaactgtt aaacgatctt gatccactgc      960

tccaacgtca ccgctcgcgc cgagaagcct ttggagcaga acccgtcccg aaccgtatct     1020

cccgcggaga cgatcgttcc ggcgagatta cgtacggtgt gcgaaagcgc gtacagcgtg     1080

agttcgatct cggtacagta ccgatcgact accggggtat actggtcggt tctgagtctc     1140

cccgtgcgcc acgtaagcga cgccacaccg acatctcgct cgacgagctg gagcgtgcaa     1200

agcgcagtgc acagaaagac taccagcggc tggagaagga gtacaaccgg tgtcggaagg     1260

aagcaccgaa cgggaagctg tgcgatcaga tctacgaaaa gctgcaacgt ctgtcggagg     1320

aagtgaatgc acgctttctc gagatggcga acctgctgca ggggttcagc gagatgggtc     1380

cagccaaaga gaagacgacg ccacagtatg aggagatgta ctatagtagc accgagcgaa     1440

gtacaagtta tcgaccggag atgcacgctc cgaaaaacga tcccaagata acgactgttg     1500

agcagcttgt gaatcagatg aacattacac aggccatccc caaggagaag ctaaggacga     1560

gtgcggagga tgagatggtc accaccactc ccatgctacc ggtgtttgat ccgagcctgc     1620

ataaaccgat cgagaatagt tctatacgga gtttggatga tctgttcgat catatgagac     1680

tgagcggaga ggacgcttcc accaccgagt ggactacaga gcggcgtgag ctgtttgagt     1740

tcgaaatcga ctccacttcc acgtcgcctg tcaccgtgaa gccatcaacc caaccgacga     1800

gtaagcgacg aacaacaacc aaaagcccac tgcaagcggc tcgcaatctc cacgatgttg     1860

tccatcaact gcaactagca cagatgcttc agccacaccc cttccacgag gatcttgtga     1920

tgagtccacc ggaaaacatt aacgagtttg tcatgtcacg atcgcgcaat cgggaggaaa     1980

tgcatcacga cacgaccccc agtccgatgc gtgccgtcgt ccatcaacaa catcaacatc     2040

tgcagcatca gactcaacct caatcacctc accaaccgtt ggtcgttggt ccaagtgctc     2100

cctttctgaa tctgtgcgat caacttcgat cggcagcagg aaatggccac ctgaagccaa     2160

cacaccctgg ggcaacattc caacactcac caggcattcc gatcacgggt gaagcaacga     2220

aagcctcctc ccagatcatt gtcaactcgg cgtttggggc tgggtatgtg ccgaatacgg     2280

tttgcttcta ccagaacgca ccaccagtag gggcacaacc aacggcgtac ggctttcgtc     2340

ctgccggttc cggtgctcct tacgtgtatc cgaacgcgcc agggtatcca ccgtaccagc     2400

cacaccagca acagccttat catcaacaac accaccatca tcatccgggt gccggaggta     2460

agcttccgtt gaatgatccc gcgatcgatg cactcattca accgcgcatt cccgaaggtg     2520

attagtgtga catccacact ctgaagagag agagacagag agttcttact gtatttttgt     2580

gtctttttcc tttcccctcc agctatgatc aacatgcccg ttagcataca gaaccttcat     2640

caagccggtg ctcgtacctc ggagctgccg gccgatcaga acggtcccat cctcctctgc     2700

tcaatgatgc agaacgtgga gcaaccgacg cgacatcacg ccgggaatga aacgcaccca     2760

gaggacgccg aagaagagct ggacgaaaat ctagacacga tgtttgcggc gggacgctca     2820

ctggcagcac gggccaaggg acgccaccac tgccgacggg gctcggtacc gtgctttagc     2880

tcgcatcagt gcgtcaaacg cagcagctgg tgtgactcca agacggactg tatggatggt     2940

agtgacgaga gtgcgtgctc ctgcgtttcg cgcctcccca agcgcaagct ctgcgatggt     3000

tatgccgact gtccgctcgg tatggacgag atgggatgct ttgggtgtga aaagttctcc     3060

ttctcctgct tccacacgga ggcggagtac cgttcggctc accggtctgg gtcgatgtgc     3120

tacagtctgc tcgaaaagtg cgacggtttc gataactgtc tgaacaggaa ggatgaacag     3180

gactgtacga tgttggtgcg tgatctgggg cactatttgg cgtactcggt cccgcactct     3240

actggggtgt tgcatcggaa ctatcgcggg aagtggtacc cggtgtgtca taatcctacg     3300

cagtgggcaa gggaagcttg cgagacggag ctcgggccac tcgatcgtga gccactgttg     3360

agccacggcc atggcagtct tcccggaccg tacattagcc agcgagcgaa cagtgccgta     3420

ccgcagcccg agtttagtga agcttgtaat ggggtttacg tacacgtgaa gtgtccggcg     3480

gtgcgatgtg gtacgagtcg gatgcacgaa cagcacgccg cccgaatcaa tgtgcggaca     3540

aggcgtgagg cgaacgagag tgaaattgtg gagagtgttc gcatcgttgg aggatcacat     3600

gccgatccgg aagcgtaccc gttcatcgtc ggtatcttcc gggatgggaa gtatcactgt     3660

ggtggcagca tttacaacga acattgggta agaggagcaa gagcctatca ttttgcattg     3720

gctcttacac tatgtgtact tcttttagat catttctgcc gctcattgct gtgacaactt     3780

cgaccagcac tacttcgagg tacggtcggg catgctgcgc aagcggagct ttgcgccgca     3840

ggttcaaatt acacgcgtca cgcacatgat cgttcatcac gcgtacagct cgtcgttgat     3900

ggcgaacgat attgcgctga tgcgggtaga gcatccgttc cactacaatc gatgggtgcg     3960

tccgatctgt atgccggagc gccatcgtac cacggacgat cgggattgga tctggggacc     4020

aaaggctggc actgtctgca ccgctattgg atggggtgca ctgcgggagc gtggtggagc     4080

acgtatgtat cattggcttc tcggaggacg cacacatctt ctctaatcca gcgcaatcct     4140

tctctttagc cgatcatctg atgcaggttt cggtgccgat cttaggctac tgcaagcaca     4200

aatccgatcg tgacagtctg cagatctgtg cggcagaaga agacggcggt catgatgcgt     4260

gccagggtga ttccggtgga ccgtttgtgt gtcagagcaa gtcgaacccg ttcgagtggt     4320

atctggccgg tgtggtaagt cacggggagg gatgtgcgcg tgcacacgaa cccggtgtct     4380

acacgcgagt ggcactgttt atcgattgga ttgcggagaa ggtaaatgcg ccactgccag     4440

cacgtactgc gcgggctgac tgtccgggga tgcgatgtat ctggggtgga gggatctgtc     4500

taccaccggg caagaagtgt aacggatacg ttaactgtct tggtggtgag gatgagtcgg     4560

gctgtgggat ggatcagatg ctacgatcga tgtcgcagcg aggtgaggaa gaaagtgagg     4620

aggagggtgg tagtgccaca cagagagctt cggatgtgga tacaacggaa gctgagacta     4680

ccgtattgtt cacatcggaa gaaacgacga cgttaagcgt gccggaagaa gcgagtgtag     4740

aagcgcagga gagtatgatc atgacgaaca cagcacagac ggaaccgatc actactacta     4800

caagtacagt tgccactacc acacctcagc ttgagctatc tactgctgaa gaaagcacaa     4860

cggaggacag ctctacctca gcaagtacct cagaagatgc acctacggaa gcttctacct     4920

cgccggagtc aaccacattg gaggtcacaa cagacctcag tacagagcca tcttccacta     4980

cgaatgaacc aacaacaacc ttcacatcaa caaccgactc tgcgatcatc ttccccatac     5040

acgatcacga acaggatcgt cctaagcaag actttgaatt cattgcaccg atcacctcct     5100

ccacaacgga agtcatttgg aaggcgttgg aaaaggcagt caaagaggta cgtggacagg     5160

tacgcactgg gaatggcact tcagtggtga acgccacaac ggaaccaatg gaagtgttct     5220

ctacggaact gccactggaa gccacgtccg aagatccgct ggaagattct tccgaccatc     5280

cattcttggt ggagttggac gtgatgcagc agcagaaaca caagcgagtg gcccaattcc     5340

gcatgacggt gcacaatgtg cacacgaaca cgaaggtgca gacgatgctg ccgaatgata     5400

cggcacagta caggcagttt tcctgcagga agtaagactt acggtggagt tagctgttga     5460

aaaaagactg tctaaattat ctttaacctg tttttctagt atcacccaga agatcaatgt     5520

ggcacaccgg tgcgatcgga tcgtagactg tgaagatggc agtgatgagc tgaactgtac     5580

ctgtcgcgac ttcctgaagg ataagtttga tttcctgatc tgcgacggca agacggactg     5640

tctcgatcaa acggatgagc tgggttgtag taagtgatct tctacggtga ggtagttttg     5700

atcaaaacaa gctaaaacaa gctcttctgt ttcctcagtg aactgtcagg ctggtcagta     5760

tgcgtgccgg atcagccagg tttgcattcc cggggtgcag gtctgcaacg gtcatccaga     5820

ctgtccgatg catgaagatg agctggattg ctgtaagtat tgctgtggac acattgttct     5880

gtgaagtcat actaaccttt ggtgctttag tggctctaac ggatggacat cgtgtgtact     5940

tcgatgcaaa caatctcacc ctcttccaca acacgggcat tgtgacgaaa aacacgaacg     6000

gaacttggga gatactgtgt ggagcggttc tcacggcaaa gacggaacat gctgtggaga     6060

agatctgttc cttcttggga tttgcgtaag tcctttatca ccgcgcgagc ttcagaaaca     6120

cctcatcata cacctttcgc ttctttttag tggtcatcga aactactcac tgctctcact     6180

cgcaccgacc gatctgcctg ttgggctgct tgcaaatcca aacaatctac actacgtcaa     6240

ccttacgctc catgctccct gtcaagcgtt gcgtgtctcc tgcgtccagc acatcaacgc     6300

taccgagcac gacattgcac actttgagca caaccacaag caagacccgg tacaggttaa     6360

cattcgccca ctgaacccga tcaaccggcc ccatcacatg ccccagatcg tgttccagga     6420

gaacgctcac attgagctgg tggaaaactt tggcgatgat tacgattggc cctggaatac     6480

gaacatctat ctcgatggag taatgatctg cagtgggctg atcatcgatg cgagctggat     6540

cattgtgtcg gggagctgta cacggttggt gaacctgcgg catcagtatc tggcggtggt     6600

ggcgggcggt gccaagtcgt acctacacat tgaagggccg tacgagcagg tggtgcgggt     6660

cgattgctac cactacatac cggaggcgga aacggtgatg ctgcatctgg cgacgaagct     6720

aagctttagc cggcacgtgc tgccgacgtt tgtgccggag aagtaagttg tgatgcgaaa     6780

tctgtctctc accattggat aaaacattat taatggattg gggtttattt gtttgtagtg     6840

aaaacctaac ggacagtgag tgtcttgcgg tgggacagga taagtacgga agaacgaaaa     6900

cgctgcgggt gcatctcaac accaccaact gcccaggcga acgggtgcga tgctaccata     6960

aggatctgaa gcagccctac tatcatcatg aatcttgtta cacaccaggt aaggagaacg     7020

agagagatta cttcaagaac tcctactgat tactctcatc ttaattcttc ctcgcagaag     7080

cgacacgatc aggtgtgatc gtgtgcaaaa caagtcgctc cggttggtat ccagtcggat     7140

tctaccagca caagcgtggt ctgtgcggat tcaacgaagt ggtgcgtgtt acgagcctgg     7200

tagaatcgta ccacaggatc cagaacgtgc tacacaagga acagtgcggt gatcagctgt     7260

acgaggaacc tcattgcgga ggaaagcgct gtcgctatgg aaagtgtgtc ggtgagaagt     7320

tgctgtgcga tcgcaaaccg gactgttccg atggatcgga tgaggaaccg gcaatgtgtg     7380

cctcacgcaa tcaaactgga agtgagtaga tggtgtcagt gtgttgtatc tgatcattat     7440

acgaactctt ttatgtcatt tttttaagat tgtctgccac atcaactacg ttgcgcgaat     7500

gaacggtgta ttgacaagtc tagtttctgc gatcgcaaga acgattgtgg agactcgacc     7560

gatgaaccgc acgattgctc ctgctacacc tatcttaagt aagatcactg taagatcagg     7620

tcgcaataca gggtttccca cgatttattg gttggatccc atcaattttt ggttggttcc     7680

catatttttt tagtgcgttc ccacgatttt ttggccgttt cccagatttt tttagtccaa     7740

ttgtattgat atccattcgg aaaataccaa taaattatgg gaacgaacta aaaatccatg     7800

cgatacgacc aaaaattcgt gggaattcac caaaaaatca tgggaactga ccaataaatc     7860

gtgggaaacc ctgtaaggag gtgttttact atttttctct ccttctctct ctctctctct     7920

ctctcgttgt cttagaatta ccgacccagg caagatctgc gacggagtgc gcaactgttg     7980

ggacaaatcg gacgagaatc cacgcgtctg tcggtgccac tcgacgagct tccggtgtgg     8040

cgagtccgac atctgcgtgc cgtatgattt tgtgtgcgac aaggaacggg actgtccgaa     8100

tggggaggat gagctgtact gttacgcact gcagcagaac tcttatgaag cgtaagaatc     8160

tctactacat ttctacgtct tgtggtatgt cacgtttgga gttaacattt ccctttttac     8220

tctttcatca ttcccctagt gggtacggtg agctgatgga gcaaagctac ggcatctggc     8280

actcaaaatg cttccccacg acgacccagt tcgacgacga gtacatgaag cgcatctgcg     8340

agcagttggg ctacagtcag gtgcgcaaaa tctttggccg agcgatcgtg caaggtgctc     8400

ggttgcgtac ggccaaccag acggaaacgc ccgttgataa gctgcgtcgt tcggcgacca     8460

aagcgatcgt gcagaacaag ttctccaagg tcgttattaa ccagaaccat acgttttaca     8520

tgaaaccgag tcggcccatg tttaaggtga tcaactggaa ctatgaggac gagcaaaact     8580

gccatcggtt ggagttgctg tgtgccccgt ga                                   8612


<210>  31
<211>  859
<212>  DNA
<213>  Anopheles gambiae


<220>
<221>  misc_feature
<223>  AGAP011377

<400>  31
tgtccctcaa ttgctctata ccgtgtgtaa tggcccgcag gatgaggtac ggtgcagtgg       60

tgctgctagt gctactggtg gctggcagtc tcgccatgta cgccaccaac aatgagcgct      120

gtacgtgcgc ccccggacca ccagactatc tctgcccgtc ggcaccactg ctgcaggtgt      180

acctgccgca cgagctgtac tgtacccgct actacaagtg taccgatggg cgtgcgatcg      240

agttccagtg tccttacgga ttgtacttcg atacgcagaa caatacctgt acgtgtgact      300

ttacgcagtg ctaccggaca gatccctgca tcgtgttcgt tgatagctgc cgttgctgca      360

acagacagtt cgaaaacacg ggcctggcgc cggaaaattt ctacgtctgc tacaacgacg      420

gatatgcggt agcgacgacc tgcccggtag cgctcgatcc ctgcactggc tcgcaggtgc      480

agctacagtt tgtaaatcaa aagtgtgagg tgccaccgcc gtgtaagttt aagtggtgtt      540

ctttgcagag cggctctgga ttgaaaatcc atcttggaat ttcgtttcag ctactaccac      600

ggtggctacc acgaccacga cagcggcctc aactacgaca acaacaaccg aggctacaac      660

aacgaccacc acggaagcta caacaacgac gaccacggag gctacaacca cgacaaccac      720

ggaggctact acaacgacga cggcggcccc ggtagcatag gagttccacc gaactgtagc      780

caaccagttc atatttattt ggttttggat ctttccgttc tactgccgcg cgcagcagaa      840

taactccgga caaggaagc                                                   859


<210>  32
<211>  16603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of the Final Targeting Vector

<400>  32
cgcttacaat ttccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg       60

ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg      120

ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgtaata      180

cgactcacta tagggcgaat tggagctcca ccgcccgggc tggttctttc cgcctcagaa      240

gccatagagc ccaccgcatc cccagcatgc ctgctattgt cttcccaatc ctcccccttg      300

ctgtcctgcc ccaccccacc ccccagaata gaatgacacc tactcagaca atgcgatgca      360

atttcctcat tttattagga aaggacagtg ggagtggcac cttccagggt caaggaaggc      420

acgggggagg ggcaaacaac agatggctgg caactagaag gcacagtcga ggctgatcag      480

cgagctctag gatctgcatt ccaccactgc tcccattcat cagttccata ggttggaatc      540

taaaatacac aaacaattag aatcagtagt ttaacacatt atacacttaa aaattttata      600

tttaccttag agctttaaat ctctgtaggt agtttgtcca attatgtcac accacagaag      660

taaggttcct tcacaaagag atcgcctgac acgatttcct gcacaggctt gagccatata      720

ctcatacatc gcatcttggc cacgttttcc acgggtttca aaattaatct caagttctac      780

gcttaacgct ttcgcctgtt cccagttatt aatatattca acgctagaac tcccctcagc      840

gaagggaagg ctgagcacta cacgcgaagc accatcaccg aaccttttga taaactcttc      900

cgttccgact tgctccatca acggttcagt gagacttaaa cctaactctt tcttaatagt      960

ttcggcatta tccactttta gtgcgagaac cttcgtcagt cctggatacg tcactttgac     1020

cacgcctcca gcttttccag agagcgggtt ttcattatct acagagtatc ccgcagcgtc     1080

gtatttattg tcggtactat aaaacccttt ccaatcatcg tcataatttc cttgtgtacc     1140

agattttggc ttttgtatac ctttttgaat ggaatctaca taaccaggtt tagtcccgtg     1200

gtacgaagaa aagttttcca tcacaaaaga tttagaagaa tcaacaacat catcaggatc     1260

catggcacgc gcttctacaa ggcgctggcc gaagaggtgc gggagtttca cgccaccaag     1320

atctgcggca cgctgttgac gctgttaagc gggtcgctgc agggtcgctc ggtgttcgag     1380

gccacacgcg tcaccttaat atgcgaagtg gacctgggac cgcgccgccc cgactgcatc     1440

tgcgtgttcg aattcgccaa tgacaagacg ctgggcgggg tttgctcgac attgggtgga     1500

aacattccag gcctgggtgg agaggctttt tgcttcctct tgcaaaacca cactgctcga     1560

cattgggtgg aaacattcca ggcctgggtg gagaggcttt ttgcttcctc ttgaaaacca     1620

cactgctcga tttgttagca gcctcgaatc aacccgggcg atcctaggcg atgagatcta     1680

gctgtcgcga agagtggcgc gccaccaccg cccagctagc tttcttaaat taagcagttt     1740

ctgtcagtgt tagggatttt tacctgcaat tccatcatat ttgaatactc tgtgactgag     1800

actgttaggg tccagtaata gccatacaaa cccctcagaa gccaatctca gtcatgtatc     1860

aatggtttat tgaacacatt cctagactga ttagtcagga gtggggatcg aaaacttcaa     1920

taaggcattc ctcagaacca atttttatat gggaaaaaca aggacttggt acatttgcaa     1980

tgtttataac atttgcaaca tttatgctat ctagacaaag cagtgctgtc tggcctttaa     2040

gctgataggc tatgtataga gacaaggaga caaggagacc tccaaagttc acaaggctca     2100

gtgaaaaagt ataacaactt tttttcaggg caagaaacaa taggtcaagt taaatttatg     2160

agctacaaaa tgaagattga gggaatatgg cagaatttta atatttaaca gagaaatgtc     2220

cttaaacccc caaagagtaa tttaaaaggg tttttattat caaacacctt tttctgtttt     2280

aagattctct atgtagagta ggttgcattg gacaattatc tttctggctt tacttactga     2340

gttctgaaat ttgaaaggat tcaccattat ttctttgtgg caaatatttg tcaaccccag     2400

aactcagcag atacaatagt ggaagaaata agtcagctct tgctccctcc cttacctcta     2460

ttctctagct cttttgctcc cctgctcccc ctctctcccc atccccttcc ttgctctctc     2520

tatgtggtca tggctgcctt ctgcttctct actatctcac actctttgcc tttctacaat     2580

aaatgcctta aaaccaaaaa ataaaaaata agaaaaaagt cagcagagga gaatgaaagg     2640

atggactact actacttcag aactgtttaa acctgagaat tttgaggaga aagattgttt     2700

agtttcaacc cttacaaggg actgaggtac atattttaca tattaaagca gtcctggcct     2760

ccagattctc ctagcatccc tcagtcccaa cctggcattc tgtctccaaa cctaaacttt     2820

tcaggtcaga ggctgggcta cctttccccc agaagcttct ccctatataa tccagacatt     2880

tggacaatga ctcccccccc catgtccccc tccttttcct tttcctcctc ttcttcctct     2940

tcctccccac cttgtcttat cctctttctc tctctctgtc tatctctctc tctctcttct     3000

cccttctctg tgtacatgag ctttctctct ccatggtaac ttccctggcc tcagttattg     3060

gggccagtga acttgcccaa gagcagcttc ccaataagcc tgcctatata taaaatatta     3120

aagacctgtt ccacaatatc caactaaagc aagctttatt taacactgac taggaagttc     3180

aacactgact acattcatgc caggattcca agagaaatgg ctttgaatta aaatcagtca     3240

tgtgatcatg caaagaaacc tctacaaatc tatgaacttt ccatatttgt ccaattaggg     3300

gtaagcatac atcctcactg acttcctgtc tgcatatttc tcacctgtgt gtgatcaagc     3360

atatcctgag cacttggggc aacaaacctt gctattgaac taaaacacaa cctccagtat     3420

tctgcagtta tttgtcctta ggtaagtgta gcatacacat taactttaaa gaattcccag     3480

agctgatttt ttgtttgttt gtttgtttgt ttgtttgttt gtttttgaga gaaagttttt     3540

ctgtgtagcc ctggctgtcc tggaactcac tctgtagacc aggcttcctc aaactcagaa     3600

atccacctgc ctctgcctcc caagtgctgg gattaaaggc gtgcaccacc acggctggct     3660

ctgacttttt ttttttttaa gagttacttt atttatatga gtacactgtt actgttttca     3720

gacaccccag aagagggcat tggatcccat tacagatggt tgtgaaccac catgttggtg     3780

gtgggaattg aactcaggac ctctggaaga gcagtcagtg ctcttaacca taccatgcag     3840

ttagtatctg agagtaaagt agcagaagct atacaccgtc tgagaatcaa ttcttgtagt     3900

gtaggcttct ggagtcccag aaactgcttt tcaagttaaa ttgggtgcag ggagggaggg     3960

ggagaatagg tctaattgtt tctgaaacct tttggcagaa gggtaaaaga taagtcagat     4020

tgcctgtttt ttgcatctta tggcttccag gtctgcaaag tgttttagaa gcttcctaga     4080

attttgttat ggaagctttt gaaaagactt agacatgttt tgtggacctg gtttgggggt     4140

agggaattta cttgaagagg gattaggtag tgtttgctag ccagtcttca atacaattca     4200

agtttaaggt catcttagat ttataaatat ttgtgttgga gacttgtgat actggtttct     4260

gagatgggga actaggtttc cttgtgaagg tccaggccca gtaagtaatg gtaatacaag     4320

tcaattcaaa actcctgaga acagcaaaat tggaacttgt cttattatat tttttattat     4380

tgtattatat ataaatgaat gctcctctta caaagtgttg gatcatattt acaaatttta     4440

gctacaacaa ccaaaaggtc aaaagaaatg gtattgttct caaatggtta ctgcatcttc     4500

aaaatgcaat gagggattcc cccgtccttc cccccccccc gccccctcac gtcactcctt     4560

gcccccgcag ggataacctt tgtgagggac tgttcattca ctatgatctg ttgtttaagg     4620

acaaagtcat gtgactttta taaagttttt ttggtttgat gtggttgagt ggatgggtaa     4680

ttaatgagtt tagctatggt ggtgacaaaa aaacacgacc cagttactca ttgaggatga     4740

tttcaatttt agctgaatac attttgtttt cccaacgtgt gtgtcattac ttcaagatct     4800

taattttaaa gtttgctaga attagtatta aggagcaccg attctgggaa cttaacagaa     4860

ggtgttctgt aaggcaagag gaaaattttt ttttttaact atttggtctc taattggctt     4920

tcatgtgccc taaaaaccga tgtttgatgt attttttctt agtgctcttt gttccttgtg     4980

agatcagtat agcaattaaa tgaaagggtc tggatatcta gtgtggaata agaaagagtt     5040

acaaagcata cctaaaacta atttcactgt ggtcggtagg tagagctctt aggctgacat     5100

cacgagctag cgaagtagca agtttagctg cactggtgat gacgcaagtc aacaaaagtc     5160

acgtgggata aaacggttgc ttccattgga aagcctggct ttagggagag gttatggacg     5220

ttacgtgcgg ttcacactga cggtattata acaactttat gcggatgcta gcgaagtttg     5280

atattctaag aacttcgctt aggttctgca acaatgagtt cttcttgcgt tcaccatctg     5340

cgtggtaatg tgaccagata gcctctgccg ctttctcctt tgccagtttc catgaaatct     5400

tacggattat ctctcactac tgctgcccta ggtaatgagg aaaagaaaat ggcggcggaa     5460

aaggctagag gcgagggcga agaggggtcc ttcagtctca cagtcgaaga gaagaaggcg     5520

ctttgtggat tagataggta cgcactgcta atacttacag gttgtctttc tctctccggg     5580

ttcaaaagac tctccaggag gcctgactgc atcttgcttg cggtgacgac tcgctttcgc     5640

ctagcactgt taacaatgtt ttgggagatt ttttactgat gtctttctgt gatcattaac     5700

aagagccatg tatttcttcc acagcagctt cttcgggttc ttgacccgat gcaaagatgg     5760

cgccaagatg aagacgctgt tgaacaaggt cagcaactgt ttaaacataa ttacttatat     5820

ttttctccta agcttttcac tgttccaagc ctggagcctc tccctactct gaaagtgctc     5880

attatagctt ttagggatct ttgaaacttt ttttttcctt ccccgtttct cctttcttgg     5940

cttactttcc tgatagtttg aggccctgcc tcagcataca gcccagagca ctgcttattt     6000

tgcagttttt ctgaggtcag ctatatcctc cagttactca tctcaagtta tgagaagacg     6060

cttggttgtt gcagcctctt gtgatataca cacgttttat tattttccca taagggacaa     6120

gttataggta aggagataaa gagtttccgt acttaaaaag aattttttac gatgcagtag     6180

taatactatg cagaaataat actgaattcc agtttggaat gttaattttt tttttttttt     6240

acttccttgt agtttatttt ccagagagtg agagagcaca cggcatttcc tttgtgaaac     6300

tttgcattgt catttagtta ttggctgctg gtatcaatca agatggtggc ttaagactga     6360

cgggcaccgg agccaattcc cactcctttc aagacctggt accaaaaaag caccgactcg     6420

gtgccacttt ttcaagttga taacggacta gccttatttt aacttgctat ttctagctct     6480

aaaacttttg aggctcatct ctgcaggtgt ttcgtccttt ccacaagata tataaagcca     6540

agaaatcgaa atactttcaa gttacggtaa gcatatgata gtccatttta aaacataatt     6600

ttaaaactgc aaactaccca agaaattatt actttctacg tcacgtattt tgtactaata     6660

tctttgtgtt tacagtcaaa ttaattccaa ttatctctct aacagccttg tatcgtatat     6720

gcaaatatga aggaatcatg ggaaataggc cctcttctag aaaaaaagca ccgactcggt     6780

gccacttttt caagttgata acggactagc cttattttaa cttgctattt ctagctctaa     6840

aacatctaca agattcaggt ctgggtgttt cgtcctttcc acaagatata taaagccaag     6900

aaatcgaaat actttcaagt tacggtaagc atatgatagt ccattttaaa acataatttt     6960

aaaactgcaa actacccaag aaattattac tttctacgtc acgtattttg tactaatatc     7020

tttgtgttta cagtcaaatt aattccaatt atctctctaa cagccttgta tcgtatatgc     7080

aaatatgaag gaatcatggg aaataggccc tcggatccaa aaaagcaccg actcggtgcc     7140

actttttcaa gttgataacg gactagcctt attttaactt gctatttcta gctctaaaac     7200

cgattcgccc ggtggcagtg ggtgtttcgt cctttccaca agatatataa agccaagaaa     7260

tcgaaatact ttcaagttac ggtaagcata tgatagtcca ttttaaaaca taattttaaa     7320

actgcaaact acccaagaaa ttattacttt ctacgtcacg tattttgtac taatatcttt     7380

gtgtttacag tcaaattaat tccaattatc tctctaacag ccttgtatcg tatatgcaaa     7440

tatgaaggaa tcatgggaaa taggccctca cgcgtgcggc cgcctcgagg gacctaataa     7500

cttcgtatag catacattat acgaagttat attaagggtt ccgcaagctc tagtcgagcc     7560

ccagctggtt ctttccgcct cagaagccat agagcccacc gcatccccag catgcctgct     7620

attgtcttcc caatcctccc ccttgctgtc ctgccccacc ccacccccca gaatagaatg     7680

acacctactc agacaatgcg atgcaatttc ctcattttat taggaaagga cagtgggagt     7740

ggcaccttcc agggtcaagg aaggcacggg ggaggggcaa acaacagatg gctggcaact     7800

agaaggcaca gtcgaggctg atcagcgagc tctagagaat tgatcccctc agaagaactc     7860

gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga gcggcgatac cgtaaagcac     7920

gaggaagcgg tcagcccatt cgccgccaag ctcttcagca atatcacggg tagccaacgc     7980

tatgtcctga tagcggtccg ccacacccag ccggccacag tcgatgaatc cagaaaagcg     8040

gccattttcc accatgatat tcggcaagca ggcatcgcca tgggtcacga cgagatcatc     8100

gccgtcgggc atgcgcgcct tgagcctggc gaacagttcg gctggcgcga gcccctgatg     8160

ctcttcgtcc agatcatcct gatcgacaag accggcttcc atccgagtac gtgctcgctc     8220

gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg tatgcagccg     8280

ccgcattgca tcagccatga tggatacttt ctcggcagga gcaaggtgag atgacaggag     8340

atcctgcccc ggcacttcgc ccaatagcag ccagtccctt cccgcttcag tgacaacgtc     8400

gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg ctgcctcgtc     8460

ctgcagttca ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg ggcgcccctg     8520

cgctgacagc cggaacacgg cggcatcaga gcagccgatt gtctgttgtg cccagtcata     8580

gccgaatagc ctctccaccc aagcggccgg agaacctgcg tgcaatccat cttgttcaat     8640

ggccgatccc atggtttagt tcctcacctt gtcgtattat actatgccga tatactatgc     8700

cgatgattaa ttgtcaacag gctgcaggtc gaaaggcccg gagatgagga agaggagaac     8760

agcgcggcag acgtgcgctt ttgaagcgtg cagaatgccg ggcctccgga ggaccttcgg     8820

gcgcccgccc cgcccctgag cccgcccctg agcccgcccc cggacccacc ccttcccagc     8880

ctctgagccc agaaagcgaa ggagcaaagc tgctattggc cgctgcccca aaggcctacc     8940

cgcttccatt gctcagcggt gctgtccatc tgcacgagac tagtgagacg tgctacttcc     9000

atttgtcacg tcctgcacga cgcgagctgc ggggcggggg ggaacttcct gactagggga     9060

ggagtagaag gtggcgcgaa ggggccacca aagaacggag ccggttggcg cctaccggtg     9120

gatgtggaat gtgtgcgagg ccagaggcca cttgtgtagc gccaagtgcc cagcggggct     9180

gctaaagcgc atgctccaga ctgccttggg aaaagcgcct cccctacccg gtagaatttc     9240

gacgacctgc agccaagcta gcttcgcgag ctcgaccgaa caaacgaccc aacacccgtg     9300

cgttttattc tgtcttttta ttgccgctca gctttacagt gacaatgacg gctggcgact     9360

gaatattagt gcttacagac agcactacat attttccgtc gatgttgaaa tcctttctca     9420

tatgtcacca taaatatcaa ataattatag caatcattta cgcgttaatg gctaatcgcc     9480

atcttccagc aggcgcacca ttgcccctgt ttcactatcc aggttacgga tatagttcat     9540

gacaatattt acattggtcc agccaccagc ttgcatgatc tccggtattg aaactccagc     9600

gcgggccata tctcgcgcgg ctccgacacg ggcactgtgt ccagaccagg ccaggtatct     9660

ctgaccagag tcatccttag cgccgtaaat caatcgatga gttgcttcaa aaatcccttc     9720

cagggcgcga gttgatagct ggctggtggc agatggcgcg gcaacaccat tttttctgac     9780

ccggcaaaac aggtagttat tcggatcatc agctacacca gagacggaaa tccatcgctc     9840

gaccagttta gttaccccca ggctaagtgc cttctctaca cctgcggtgc taaccagcgt     9900

tttcgttctg ccaatatgga ttaacattct cccaccgtca gtacgtgaga tatctttaac     9960

cctgatcctg gcaatttcgg ctatacgtaa cagggtgtta taagcaatcc ccagaaatgc    10020

cagattacgt atatcctggc agcgatcgct attttccatg agtgaacgaa cctggtcgaa    10080

atcagtgcgt tcgaacgcta gagcctgttt tgcacgttca ccggcatcaa cgttttcttt    10140

tcggatccgc cgcataacca gtgaaacagc attgctgtca cttggtcgtg gcagcccgga    10200

ccgacgatga agcatgttta gctggcccaa atgttgctgg atagttttta ctgccagacc    10260

gcgcgcctga agatatagaa gataatcgcg aacatcttca ggttctgcgg gaaaccattt    10320

ccggttattc aacttgcacc atgccgccca cgaccggcaa acggacagaa gcattttcca    10380

ggtatgctca gaaaacgcct ggcgatccct gaacatgtcc atcaggttct tgcgaacctc    10440

atcactcgtt gcatcgaccg gtaatgcagg caaattttgg tgtacggtca gtaaattgga    10500

caccttcctc ttcttcttgg gcatggccgc aggaaagcag agccctgaag ctcccatcac    10560

cggccaataa gagccaagcc tgcagtgtga cctcatagag caatgtgcca gccagcctga    10620

ccccaagggc cctcaggctt gggcacactg tctctaggac cctgagagaa agacataccc    10680

atttctgctt agggccctga ggatgagccc aggggtggct tggcactgaa gcaaaggaca    10740

ctggggctca gctggcagca aagtgaccag gatgctgagg ctttgaccca gaagccagag    10800

gccagaggcc aggacttctc ttggtcccag tccaccctca ctcagagctt taccaatgcc    10860

ctctggatag ttgtcgggta acggtggacg ccactgattc tctggccagc ctaggacttc    10920

gccattccgc tgattctgct cttccagcca ctggctgacc ggttggaagt actccagcag    10980

tgccttggca tccagggcat ctgagcctac caggtccttc agtacctcct gccagggcct    11040

ggagcagcca gcctgcaaca cctgcctgcc aagcagagtg accactgtgg gcacagggga    11100

cacagggtgg ggcccacaac agcaccattg tccacttgtc cctcactagt aaaagaactc    11160

tagggttgcg gggggtgggg gaggtctctg tgaggctggt aagggatatt tgcctggccc    11220

atggagctag cttggctgga cgtaaactcc tcttcagacc taataacttc gtatagcata    11280

cattatacga agttatatta agggttattg aatatgatcg gaattgggct gcaggaattc    11340

gatagcttgg ctgcaggtcg acgtacgtag caagcttgat gggccctggt accgaaatag    11400

agggaggaga ggggaaatga aacagtttta gaaaggaaac agggtagttt taccaagaaa    11460

atattaaacc tagcaagtac aggttaatga aaagtattcc ccattactta aaaggagaat    11520

tatcaagtct ttttaaacct ttaaaaaaag attcttagcc gggcggggtg gcacatgcct    11580

ttaatcccag cacttgggag gcagaggcag gcagatttct gagtttgagg ccagtctggt    11640

ctacagagtg agttccagga cagccagggc tacacagaga taccctgtct caaaaaaaaa    11700

aaaaaaattc ttaaaggtaa catatttaga tacttgtaaa ccatagcaaa aaaagcacag    11760

atctgtgaca tacatacttg ttaccattat atagtttccg ttctaatgaa aatcagtgat    11820

tataaacttg ataatttcat accaccaatg aagtattaat agtattcttt tttggttttt    11880

ggagacaggg tttctcagta tagctctggt tgctatacag ttaatagtgt tcttaacata    11940

tatgtgtata tataaattta tgtatgtatg tatatatata tatacatata tatatatgca    12000

tattatgcac acataatttt tggtttggtt tggttgtgag cctagccttt aaggactgag    12060

tccaagattt aaacactctt caggtgatat gtatagaaac atatttctgt ttactagtag    12120

gttgctaggt ttctggtgta cagtgggtaa ttttaaattt gatgttaacc tccacactct    12180

tttaagattt catggtaaaa gcttaaagaa atgattttgt ctagttttta tttttatttt    12240

ttaatttttt ttattttttt ggtttttgga gacagggttt ctctgtatag ctctggctgt    12300

cctggaactc actttgtaga ccaggctggc ctcaaactca gaaatctgcc tgtctctccc    12360

tcctgagtgc tgggattaaa ggcatgcacc accacgcctg acgtggtttt taaagatata    12420

attatttaac tatatcttag catttctttt ttttttttag agtagtaatt cttatattat    12480

aaaaaagact tggtgttgaa tgtatttttg gagtgactac aacaactatg tgtgatcctg    12540

tttgtcctag aactcacaga cagaaatatc actttctctg ctttctcatt gctcattgct    12600

aagattaaag ccctgttttc ctaaaactgg cttcttttaa atttaataat tttgtatata    12660

ttcatgtctg gaagttatag gacaaattgt ggaagtcagt tttcttcttc tatcatgtca    12720

gggctggagg caagtccttt tactagctaa gccacttcct tgaactttca gtttatgtgt    12780

atagtgtttc tactgcttgt aggtctattc cacttgagtg tctggttcta ctaaggagtt    12840

tagaagagac agacctatgg aactggaatt agtgaaggtt gtgagcttca ctaatcaaac    12900

cagtgttctc ttgcagagct ctttagttta tttaagtagc atatattttt caggtgcttt    12960

gtaatatcaa tttatatgtt agtaaactgt tttcaaatat tgaaataaca ggtatttttt    13020

aactaattgc aacagcattt taaaaatgag aagttaaaaa caaaatatga gaaactatca    13080

agtgccactg ttcttagaac atttatgagt tgtgccttta ttaaacattg agtaatatgt    13140

atttttgttt tagatcagtc tcagcctttc taatgcagtt tctcatgttg tgatgacccc    13200

caaccataaa attatttttg ttgttattca taactaattt tggtgctgtt atgaatcatt    13260

atgtaaatat ctgaatagtt tattagtgac caaaaaggta ttttgaccca taggttgaga    13320

accattattt tagacactgt cttagtctat attttgttgc ccagaatagc tttaaatttg    13380

aagaagtact catctctcag cctccaagta ttgagatttc aggcatgagc cactactctt    13440

taacagttat taaaatgtat tacaattata atttaaaatg acaagtatta aaaactgaaa    13500

tatagggctg gtgagatggc tcagtgggta agagcacccg actgctcttc cgaaggtcca    13560

gagttcaaat cccagcaacc acatggtggc tcacaaccat ccataacgag atctgactcc    13620

ctcttctgga gtgtctgaag acagctacag tgtacttaca tataataaat aaatctttaa    13680

aaaaaaaaaa acaaaaaaaa acctgaaata tataaagggc aattgatgga tggtggtgga    13740

atatcccttt atcctagcac tgtgcagagg cagttgggtc tcttataagt ttgaggccag    13800

cctgatctac atagcaagtt tcaggacagc aagattagac agagaaacct gcctcaaaaa    13860

aggacaattt gtttttaagc ctgacagtgg tggcatacac ctttaaaccc agcacttggg    13920

ggacataggc agatagatct ttggcggccg cgtaccagct tttgttccct ttagtgaggg    13980

ttaatttcga gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg    14040

ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa    14100

tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac    14160

ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt    14220

gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga    14280

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca    14340

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg    14400

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt    14460

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc    14520

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct    14580

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc    14640

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta    14700

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca    14760

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag    14820

tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag    14880

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt    14940

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa    15000

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg    15060

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga    15120

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta    15180

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc    15240

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg    15300

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga    15360

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt    15420

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt    15480

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc    15540

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc    15600

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca    15660

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag    15720

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg    15780

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa    15840

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa    15900

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga    15960

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga    16020

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg    16080

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt    16140

ccccgaaaag tgccacctga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg    16200

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc    16260

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc    16320

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt    16380

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag    16440

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg    16500

gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag    16560

ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taa                      16603


<210>  33
<211>  6594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence confirmed regions of the Final Targeting Vector

<400>  33
ggaccgcgcc gccccgactg catctgcgtg ttcgaattcg ccaatgacaa gacgctgggc       60

ggggtttgct cgacattggg tggaaacatt ccaggcctgg gtggagaggc tttttgcttc      120

ctcttgcaaa accacactgc tcgacattgg gtggaaacat tccaggcctg ggtggagagg      180

ctttttgctt cctcttgaaa accacactgc tcgatttgtt agcagcctcg aatcaacccg      240

ggcgatccta ggcgatgaga tctagctgtc gcgaagagtg gcgcgccacc accgcccagc      300

tagctttctt aaattaagca gtttctgtca gtgttaggga tttttacctg caattccatc      360

atatttgaat actctgtgac tgagactgtt agggtccagt aatagccata caaacccctc      420

agaagccaat ctcagtcatg tatcaatggt ttattgaaca cattcctaga ctgattagtc      480

aggagtgggg atcgaaaact tcaataaggc attcctcaga accaattttt atatgggaaa      540

aacaaggact tggtacattt gcaatgttta taacatttgc aacatttatg ctatctagac      600

aaagcagtgc tgtctggcct ttaagctgat aggctatgta tagagacaag gagacaagga      660

gacctccaaa gttcacaagg ctcagtgaaa aagtataaca actttttttc agggcaagaa      720

acaataggtc aagttaaatt tatgagctac aaaatgaaga ttgagggaat atggcagaat      780

tttaatattt aacagagaaa tgtccttaaa cccccaaaga gtaatttaaa agggttttta      840

ttatcaaaca cctttttctg ttttaagatt ctctatgtag agtaggttgc attggacaat      900

tatctttctg gctttactta ctgagttctg aaatttgaaa ggattcacca ttatttcttt      960

gtggcaaata tttgtcaacc ccagaactca gcagatacaa tagtggaaga aataagtcag     1020

ctcttgctcc ctcccttacc tctattctct agctcttttg ctcccctgct ccccctctct     1080

ccccatcccc ttccttgctc tctctatgtg gtcatggctg ccttctgctt ctctactatc     1140

tcacactctt tgcctttcta caataaatgc cttaaaacca aaaaataaaa aataagaaaa     1200

aagtcagcag aggagaatga aaggatggac tactactact tcagaactgt ttaaacctga     1260

gaattttgag gagaaagatt gtttagtttc aacccttaca agggactgag gtacatattt     1320

tacatattaa agcagtcctg gcctccagat tctcctagca tccctcagtc ccaacctggc     1380

attctgtctc caaacctaaa cttttcaggt cagaggctgg gctacctttc ccccagaagc     1440

ttctccctat ataatccaga catttggaca atgactcccc cccccatgtc cccctccttt     1500

tccttttcct cctcttcttc ctcttcctcc ccaccttgtc ttatcctctt tctctctctc     1560

tgtctatctc tctctctctc ttctcccttc tctgtgtaca tgagctttct ctctccatgg     1620

taacttccct ggcctcagtt attggggcca gtgaacttgc ccaagagcag cttcccaata     1680

agcctgccta tatataaaat attaaagacc tgttccacaa tatccaacta aagcaagctt     1740

tatttaacac tgactaggaa gttcaacact gactacattc atgccaggat tccaagagaa     1800

atggctttga attaaaatca gtcatgtgat catgcaaaga aacctctaca aatctatgaa     1860

ctttccatat ttgtccaatt aggggtaagc atacatcctc actgacttcc tgtctgcata     1920

tttctcacct gtgtgtgatc aagcatatcc tgagcacttg gggcaacaaa ccttgctatt     1980

gaactaaaac acaacctcca gtattctgca gttatttgtc cttaggtaag tgtagcatac     2040

acattaactt taaagaattc ccagagctga ttttttgttt gtttgtttgt ttgtttgttt     2100

gtttgttttt gagagaaagt ttttctgtgt agccctggct gtcctggaac tcactctgta     2160

gaccaggctt cctcaaactc agaaatccac ctgcctctgc ctcccaagtg ctgggattaa     2220

aggcgtgcac caccacggct ggctctgact tttttttttt ttaagagtta ctttatttat     2280

atgagtacac tgttactgtt ttcagacacc ccagaagagg gcattggatc ccattacaga     2340

tggttgtgaa ccaccatgtt ggtggtggga attgaactca ggacctctgg aagagcagtc     2400

agtgctctta accataccat gcagttagta tctgagagta aagtagcaga agctatacac     2460

cgtctgagaa tcaattcttg tagtgtaggc ttctggagtc ccagaaactg cttttcaagt     2520

taaattgggt gcagggaggg agggggagaa taggtctaat tgtttctgaa accttttggc     2580

agaagggtaa aagataagtc agattgcctg ttttttgcat cttatggctt ccaggtctgc     2640

aaagtgtttt agaagcttcc tagaattttg ttatggaagc ttttgaaaag acttagacat     2700

gttttgtgga cctggtttgg gggtagggaa tttacttgaa gagggattag gtagtgtttg     2760

ctagccagtc ttcaatacaa ttcaagttta aggtcatctt agatttataa atatttgtgt     2820

tggagacttg tgatactggt ttctgagatg gggaactagg tttccttgtg aaggtccagg     2880

cccagtaagt aatggtaata caagtcaatt caaaactcct gagaacagca aaattggaac     2940

ttgtcttatt atatttttta ttattgtatt atatataaat gaatgctcct cttacaaagt     3000

gttggatcat atttacaaat tttagctaca acaaccaaaa ggtcaaaaga aatggtattg     3060

ttctcaaatg gttactgcat cttcaaaatg caatgaggga ttcccccgtc cttccccccc     3120

ccccgccccc tcacgtcact ccttgccccc gcagggataa cctttgtgag ggactgttca     3180

ttcactatga tctgttgttt aaggacaaag tcatgtgact tttataaagt ttttttggtt     3240

tgatgtggtt gagtggatgg gtaattaatg agtttagcta tggtggtgac aaaaaaacac     3300

gacccagtta ctcattgagg atgatttcaa ttttagctga atacattttg ttttcccaac     3360

gtgtgtgtca ttacttcaag atcttaattt taaagtttgc tagaattagt attaaggagc     3420

accgattctg ggaacttaac agaaggtgtt ctgtaaggca agaggaaaat tttttttttt     3480

aactatttgg tctctaattg gctttcatgt gccctaaaaa ccgatgtttg atgtattttt     3540

tcttagtgct ctttgttcct tgtgagatca gtatagcaat taaatgaaag ggtctggata     3600

tctagtgtgg aataagaaag agttacaaag catacctaaa actaatttca ctgtggtcgg     3660

taggtagagc tcttaggctg acatcacgag ctagcgaagt agcaagttta gctgcactgg     3720

tgatgacgca agtcaacaaa agtcacgtgg gataaaacgg ttgcttccat tggaaagcct     3780

ggctttaggg agaggttatg gacgttacgt gcggttcaca ctgacggtat tataacaact     3840

ttatgcggat gctagcgaag tttgatattc taagaacttc gcttaggttc tgcaacaatg     3900

agttcttctt gcgttcacca tctgcgtggt aatgtgacca gatagcctct gccgctttct     3960

cctttgccag tttccatgaa atcttacgga ttatctctca ctactgctgc cctaggtaat     4020

gaggaaaaga aaatggcggc ggaaaaggct agaggcgagg gcgaagaggg gtccttcagt     4080

ctcacagtcg aagagaagaa ggcgctttgt ggattagata ggtacgcact gctaatactt     4140

acaggttgtc tttctctctc cgggttcaaa agactctcca ggaggcctga ctgcatcttg     4200

cttgcggtga cgactcgctt tcgcctagca ctgttaacaa tgttttggga gattttttac     4260

tgatgtcttt ctgtgatcat taacaagagc catgtatttc ttccacagca gcttcttcgg     4320

gttcttgacc cgatgcaaag atggcgccaa gatgaagacg ctgttgaaca aggtcagcaa     4380

ctgtttaaac ataattactt atatttttct cctaagcttt tcactgttcc aagcctggag     4440

cctctcccta ctctgaaagt gctcattata gcttttaggg atctttgaaa cttttttttt     4500

ccttccccgt ttctcctttc ttggcttact ttcctgatag tttgaggccc tgcctcagca     4560

tacagcccag agcactgctt attttgcagt ttttctgagg tcagctatat cctccagtta     4620

ctcatctcaa gttatgagaa gacgcttggt tgttgcagcc tcttgtgata tacacacgtt     4680

ttattatttt cccataaggg acaagttata ggtaaggaga taaagagttt ccgtacttaa     4740

aaagaatttt ttacgatgca gtagtaatac tatgcagaaa taatactgaa ttccagtttg     4800

gaatgttaat tttttttttt ttttacttcc ttgtagttta ttttccagag agtgagagag     4860

cacacggcat ttcctttgtg aaactttgca ttgtcattta gttattggct gctggtatca     4920

atcaagatgg tggcttaaga ctgacgggca ccggagccaa ttcccactcc tttcaagacc     4980

tggtaccaaa aaagcaccga ctcggtgcca ctttttcaag ttgataacgg actagcctta     5040

ttttaacttg ctatttctag ctctaaaact tttgaggctc atctctgcag gtgtttcgtc     5100

ctttccacaa gatatataaa gccaagaaat cgaaatactt tcaagttacg gtaagcatat     5160

gatagtccat tttaaaacat aattttaaaa ctgcaaacta cccaagaaat tattactttc     5220

tacgtcacgt attttgtact aatatctttg tgtttacagt caaattaatt ccaattatct     5280

ctctaacagc cttgtatcgt atatgcaaat atgaaggaat catgggaaat aggccctctt     5340

ctagaaaaaa agcaccgact cggtgccact ttttcaagtt gataacggac tagccttatt     5400

ttaacttgct atttctagct ctaaaacatc tacaagattc aggtctgggt gtttcgtcct     5460

ttccacaaga tatataaagc caagaaatcg aaatactttc aagttacggt aagcatatga     5520

tagtccattt taaaacataa ttttaaaact gcaaactacc caagaaatta ttactttcta     5580

cgtcacgtat tttgtactaa tatctttgtg tttacagtca aattaattcc aattatctct     5640

ctaacagcct tgtatcgtat atgcaaatat gaaggaatca tgggaaatag gccctcggat     5700

ccaaaaaagc accgactcgg tgccactttt tcaagttgat aacggactag ccttatttta     5760

acttgctatt tctagctcta aaaccgattc gcccggtggc agtgggtgtt tcgtcctttc     5820

cacaagatat ataaagccaa gaaatcgaaa tactttcaag ttacggtaag catatgatag     5880

tccattttaa aacataattt taaaactgca aactacccaa gaaattatta ctttctacgt     5940

cacgtatttt gtactaatat ctttgtgttt acagtcaaat taattccaat tatctctcta     6000

acagccttgt atcgtatatg caaatatgaa ggaatcatgg gaaataggcc ctcacgcgtg     6060

cggccgcctc gagggaccta ataacttcgt atagcataca ttatacgaag ttatattaag     6120

ggttccgcaa gctctagtcg agccccagct ggttctttcc gcctcagaag ccatagagcc     6180

caccgcatcc ccagcatgcc tgctattgtc ttcccaatcc tcccccttgc tgtcctgccc     6240

caccccaccc cccagaatag aatgacacct actcagacaa tgcgatgcaa tttcctcatt     6300

ttattaggaa aggacagtgg gagtggcacc ttccagggtc aaggaaggca cgggggaggg     6360

gcaaacaaca gatggctggc aactagaagg cacagtcgag gctgatcagc gagctctaga     6420

gaattgatcc cctcagaaga actcgtcaag aaggcgatag aaggcgatgc gctgcgaatc     6480

gggagcggcg ataccgtaaa gcacgaggaa gcggtcagcc cattcgccgc caagctcttc     6540

agcaatatca cgggtagcca acgctatgtc ctgatagcgg tccgccacac ccag           6594


<210>  34
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KI region

<400>  34
actgacgggc accggagcca attcccactc ctttcaagac ctggtaccaa aaaagcaccg       60

actcggtgcc actttttcaa gttgataacg gactagcctt attttaactt gctatttcta      120

gctctaaaac ttttgaggct catctctgca ggtgtttcgt cctttccaca agatatataa      180

agccaagaaa tcgaaatact ttcaagttac ggtaagcata tgatagtcca ttttaaaaca      240

taattttaaa actgcaaact acccaagaaa ttattacttt ctacgtcacg tattttgtac      300

taatatcttt gtgtttacag tcaaattaat tccaattatc tctctaacag ccttgtatcg      360

tatatgcaaa tatgaaggaa tcatgggaaa taggccctct tctagaaaaa aagcaccgac      420

tcggtgccac tttttcaagt tgataacgga ctagccttat tttaacttgc tatttctagc      480

tctaaaacat ctacaagatt caggtctggg tgtttcgtcc tttccacaag atatataaag      540

ccaagaaatc gaaatacttt caagttacgg taagcatatg atagtccatt ttaaaacata      600

attttaaaac tgcaaactac ccaagaaatt attactttct acgtcacgta ttttgtacta      660

atatctttgt gtttacagtc aaattaattc caattatctc tctaacagcc ttgtatcgta      720

tatgcaaata tgaaggaatc atgggaaata ggccctcgga tccaaaaaag caccgactcg      780

gtgccacttt ttcaagttga taacggacta gccttatttt aacttgctat ttctagctct      840

aaaaccgatt cgcccggtgg cagtgggtgt ttcgtccttt ccacaagata tataaagcca      900

agaaatcgaa atactttcaa gttacggtaa gcatatgata gtccatttta aaacataatt      960

ttaaaactgc aaactaccca agaaattatt actttctacg tcacgtattt tgtactaata     1020

tctttgtgtt tacagtcaaa ttaattccaa ttatctctct aacagccttg tatcgtatat     1080

gcaaatatga aggaatcatg ggaaataggc cctcacgcgt gcggccgc                  1128


<210>  35
<211>  4646
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Homology arm

<400>  35
accaccgccc agctagcttt cttaaattaa gcagtttctg tcagtgttag ggatttttac       60

ctgcaattcc atcatatttg aatactctgt gactgagact gttagggtcc agtaatagcc      120

atacaaaccc ctcagaagcc aatctcagtc atgtatcaat ggtttattga acacattcct      180

agactgatta gtcaggagtg gggatcgaaa acttcaataa ggcattcctc agaaccaatt      240

tttatatggg aaaaacaagg acttggtaca tttgcaatgt ttataacatt tgcaacattt      300

atgctatcta gacaaagcag tgctgtctgg cctttaagct gataggctat gtatagagac      360

aaggagacaa ggagacctcc aaagttcaca aggctcagtg aaaaagtata acaacttttt      420

ttcagggcaa gaaacaatag gtcaagttaa atttatgagc tacaaaatga agattgaggg      480

aatatggcag aattttaata tttaacagag aaatgtcctt aaacccccaa agagtaattt      540

aaaagggttt ttattatcaa acaccttttt ctgttttaag attctctatg tagagtaggt      600

tgcattggac aattatcttt ctggctttac ttactgagtt ctgaaatttg aaaggattca      660

ccattatttc tttgtggcaa atatttgtca accccagaac tcagcagata caatagtgga      720

agaaataagt cagctcttgc tccctccctt acctctattc tctagctctt ttgctcccct      780

gctccccctc tctccccatc cccttccttg ctctctctat gtggtcatgg ctgccttctg      840

cttctctact atctcacact ctttgccttt ctacaataaa tgccttaaaa ccaaaaaata      900

aaaaataaga aaaaagtcag cagaggagaa tgaaaggatg gactactact acttcagaac      960

tgtttaaacc tgagaatttt gaggagaaag attgtttagt ttcaaccctt acaagggact     1020

gaggtacata ttttacatat taaagcagtc ctggcctcca gattctccta gcatccctca     1080

gtcccaacct ggcattctgt ctccaaacct aaacttttca ggtcagaggc tgggctacct     1140

ttcccccaga agcttctccc tatataatcc agacatttgg acaatgactc ccccccccat     1200

gtccccctcc ttttcctttt cctcctcttc ttcctcttcc tccccacctt gtcttatcct     1260

ctttctctct ctctgtctat ctctctctct ctcttctccc ttctctgtgt acatgagctt     1320

tctctctcca tggtaacttc cctggcctca gttattgggg ccagtgaact tgcccaagag     1380

cagcttccca ataagcctgc ctatatataa aatattaaag acctgttcca caatatccaa     1440

ctaaagcaag ctttatttaa cactgactag gaagttcaac actgactaca ttcatgccag     1500

gattccaaga gaaatggctt tgaattaaaa tcagtcatgt gatcatgcaa agaaacctct     1560

acaaatctat gaactttcca tatttgtcca attaggggta agcatacatc ctcactgact     1620

tcctgtctgc atatttctca cctgtgtgtg atcaagcata tcctgagcac ttggggcaac     1680

aaaccttgct attgaactaa aacacaacct ccagtattct gcagttattt gtccttaggt     1740

aagtgtagca tacacattaa ctttaaagaa ttcccagagc tgattttttg tttgtttgtt     1800

tgtttgtttg tttgtttgtt tttgagagaa agtttttctg tgtagccctg gctgtcctgg     1860

aactcactct gtagaccagg cttcctcaaa ctcagaaatc cacctgcctc tgcctcccaa     1920

gtgctgggat taaaggcgtg caccaccacg gctggctctg actttttttt tttttaagag     1980

ttactttatt tatatgagta cactgttact gttttcagac accccagaag agggcattgg     2040

atcccattac agatggttgt gaaccaccat gttggtggtg ggaattgaac tcaggacctc     2100

tggaagagca gtcagtgctc ttaaccatac catgcagtta gtatctgaga gtaaagtagc     2160

agaagctata caccgtctga gaatcaattc ttgtagtgta ggcttctgga gtcccagaaa     2220

ctgcttttca agttaaattg ggtgcaggga gggaggggga gaataggtct aattgtttct     2280

gaaacctttt ggcagaaggg taaaagataa gtcagattgc ctgttttttg catcttatgg     2340

cttccaggtc tgcaaagtgt tttagaagct tcctagaatt ttgttatgga agcttttgaa     2400

aagacttaga catgttttgt ggacctggtt tgggggtagg gaatttactt gaagagggat     2460

taggtagtgt ttgctagcca gtcttcaata caattcaagt ttaaggtcat cttagattta     2520

taaatatttg tgttggagac ttgtgatact ggtttctgag atggggaact aggtttcctt     2580

gtgaaggtcc aggcccagta agtaatggta atacaagtca attcaaaact cctgagaaca     2640

gcaaaattgg aacttgtctt attatatttt ttattattgt attatatata aatgaatgct     2700

cctcttacaa agtgttggat catatttaca aattttagct acaacaacca aaaggtcaaa     2760

agaaatggta ttgttctcaa atggttactg catcttcaaa atgcaatgag ggattccccc     2820

gtccttcccc cccccccgcc ccctcacgtc actccttgcc cccgcaggga taacctttgt     2880

gagggactgt tcattcacta tgatctgttg tttaaggaca aagtcatgtg acttttataa     2940

agtttttttg gtttgatgtg gttgagtgga tgggtaatta atgagtttag ctatggtggt     3000

gacaaaaaaa cacgacccag ttactcattg aggatgattt caattttagc tgaatacatt     3060

ttgttttccc aacgtgtgtg tcattacttc aagatcttaa ttttaaagtt tgctagaatt     3120

agtattaagg agcaccgatt ctgggaactt aacagaaggt gttctgtaag gcaagaggaa     3180

aatttttttt tttaactatt tggtctctaa ttggctttca tgtgccctaa aaaccgatgt     3240

ttgatgtatt ttttcttagt gctctttgtt ccttgtgaga tcagtatagc aattaaatga     3300

aagggtctgg atatctagtg tggaataaga aagagttaca aagcatacct aaaactaatt     3360

tcactgtggt cggtaggtag agctcttagg ctgacatcac gagctagcga agtagcaagt     3420

ttagctgcac tggtgatgac gcaagtcaac aaaagtcacg tgggataaaa cggttgcttc     3480

cattggaaag cctggcttta gggagaggtt atggacgtta cgtgcggttc acactgacgg     3540

tattataaca actttatgcg gatgctagcg aagtttgata ttctaagaac ttcgcttagg     3600

ttctgcaaca atgagttctt cttgcgttca ccatctgcgt ggtaatgtga ccagatagcc     3660

tctgccgctt tctcctttgc cagtttccat gaaatcttac ggattatctc tcactactgc     3720

tgccctaggt aatgaggaaa agaaaatggc ggcggaaaag gctagaggcg agggcgaaga     3780

ggggtccttc agtctcacag tcgaagagaa gaaggcgctt tgtggattag ataggtacgc     3840

actgctaata cttacaggtt gtctttctct ctccgggttc aaaagactct ccaggaggcc     3900

tgactgcatc ttgcttgcgg tgacgactcg ctttcgccta gcactgttaa caatgttttg     3960

ggagattttt tactgatgtc tttctgtgat cattaacaag agccatgtat ttcttccaca     4020

gcagcttctt cgggttcttg acccgatgca aagatggcgc caagatgaag acgctgttga     4080

acaaggtcag caactgttta aacataatta cttatatttt tctcctaagc ttttcactgt     4140

tccaagcctg gagcctctcc ctactctgaa agtgctcatt atagctttta gggatctttg     4200

aaactttttt tttccttccc cgtttctcct ttcttggctt actttcctga tagtttgagg     4260

ccctgcctca gcatacagcc cagagcactg cttattttgc agtttttctg aggtcagcta     4320

tatcctccag ttactcatct caagttatga gaagacgctt ggttgttgca gcctcttgtg     4380

atatacacac gttttattat tttcccataa gggacaagtt ataggtaagg agataaagag     4440

tttccgtact taaaaagaat tttttacgat gcagtagtaa tactatgcag aaataatact     4500

gaattccagt ttggaatgtt aatttttttt tttttttact tccttgtagt ttattttcca     4560

gagagtgaga gagcacacgg catttccttt gtgaaacttt gcattgtcat ttagttattg     4620

gctgctggta tcaatcaaga tggtgg                                          4646


<210>  36
<211>  2550
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Homology arm

<400>  36
gaaatagagg gaggagaggg gaaatgaaac agttttagaa aggaaacagg gtagttttac       60

caagaaaata ttaaacctag caagtacagg ttaatgaaaa gtattcccca ttacttaaaa      120

ggagaattat caagtctttt taaaccttta aaaaaagatt cttagccggg cggggtggca      180

catgccttta atcccagcac ttgggaggca gaggcaggca gatttctgag tttgaggcca      240

gtctggtcta cagagtgagt tccaggacag ccagggctac acagagatac cctgtctcaa      300

aaaaaaaaaa aaaattctta aaggtaacat atttagatac ttgtaaacca tagcaaaaaa      360

agcacagatc tgtgacatac atacttgtta ccattatata gtttccgttc taatgaaaat      420

cagtgattat aaacttgata atttcatacc accaatgaag tattaatagt attctttttt      480

ggtttttgga gacagggttt ctcagtatag ctctggttgc tatacagtta atagtgttct      540

taacatatat gtgtatatat aaatttatgt atgtatgtat atatatatat acatatatat      600

atatgcatat tatgcacaca taatttttgg tttggtttgg ttgtgagcct agcctttaag      660

gactgagtcc aagatttaaa cactcttcag gtgatatgta tagaaacata tttctgttta      720

ctagtaggtt gctaggtttc tggtgtacag tgggtaattt taaatttgat gttaacctcc      780

acactctttt aagatttcat ggtaaaagct taaagaaatg attttgtcta gtttttattt      840

ttatttttta atttttttta tttttttggt ttttggagac agggtttctc tgtatagctc      900

tggctgtcct ggaactcact ttgtagacca ggctggcctc aaactcagaa atctgcctgt      960

ctctccctcc tgagtgctgg gattaaaggc atgcaccacc acgcctgacg tggtttttaa     1020

agatataatt atttaactat atcttagcat ttcttttttt tttttagagt agtaattctt     1080

atattataaa aaagacttgg tgttgaatgt atttttggag tgactacaac aactatgtgt     1140

gatcctgttt gtcctagaac tcacagacag aaatatcact ttctctgctt tctcattgct     1200

cattgctaag attaaagccc tgttttccta aaactggctt cttttaaatt taataatttt     1260

gtatatattc atgtctggaa gttataggac aaattgtgga agtcagtttt cttcttctat     1320

catgtcaggg ctggaggcaa gtccttttac tagctaagcc acttccttga actttcagtt     1380

tatgtgtata gtgtttctac tgcttgtagg tctattccac ttgagtgtct ggttctacta     1440

aggagtttag aagagacaga cctatggaac tggaattagt gaaggttgtg agcttcacta     1500

atcaaaccag tgttctcttg cagagctctt tagtttattt aagtagcata tatttttcag     1560

gtgctttgta atatcaattt atatgttagt aaactgtttt caaatattga aataacaggt     1620

attttttaac taattgcaac agcattttaa aaatgagaag ttaaaaacaa aatatgagaa     1680

actatcaagt gccactgttc ttagaacatt tatgagttgt gcctttatta aacattgagt     1740

aatatgtatt tttgttttag atcagtctca gcctttctaa tgcagtttct catgttgtga     1800

tgacccccaa ccataaaatt atttttgttg ttattcataa ctaattttgg tgctgttatg     1860

aatcattatg taaatatctg aatagtttat tagtgaccaa aaaggtattt tgacccatag     1920

gttgagaacc attattttag acactgtctt agtctatatt ttgttgccca gaatagcttt     1980

aaatttgaag aagtactcat ctctcagcct ccaagtattg agatttcagg catgagccac     2040

tactctttaa cagttattaa aatgtattac aattataatt taaaatgaca agtattaaaa     2100

actgaaatat agggctggtg agatggctca gtgggtaaga gcacccgact gctcttccga     2160

aggtccagag ttcaaatccc agcaaccaca tggtggctca caaccatcca taacgagatc     2220

tgactccctc ttctggagtg tctgaagaca gctacagtgt acttacatat aataaataaa     2280

tctttaaaaa aaaaaaaaca aaaaaaaacc tgaaatatat aaagggcaat tgatggatgg     2340

tggtggaata tccctttatc ctagcactgt gcagaggcag ttgggtctct tataagtttg     2400

aggccagcct gatctacata gcaagtttca ggacagcaag attagacaga gaaacctgcc     2460

tcaaaaaagg acaatttgtt tttaagcctg acagtggtgg catacacctt taaacccagc     2520

acttggggga cataggcaga tagatctttg                                      2550


<210>  37
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  loxP sites

<400>  37
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  38
<211>  353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon 1

<400>  38
attggaaagc ctggctttag ggagaggtta tggacgttac gtgcggttca cactgacggt       60

attataacaa ctttatgcgg atgctagcga agtttgatat tctaagaact tcgcttaggt      120

tctgcaacaa tgagttcttc ttgcgttcac catctgcgtg gtaatgtgac cagatagcct      180

ctgccgcttt ctcctttgcc agtttccatg aaatcttacg gattatctct cactactgct      240

gccctaggta atgaggaaaa gaaaatggcg gcggaaaagg ctagaggcga gggcgaagag      300

gggtccttca gtctcacagt cgaagagaag aaggcgcttt gtggattaga tag             353


<210>  39
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon 2

<400>  39
cagcttcttc gggttcttga cccgatgcaa agatggcgcc aagatgaaga cgctgttgaa       60

caag                                                                    64


<210>  40
<211>  4335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 adapted for mammalian expression

<400>  40
atggactata aggaccacga cggagactac aaggatcatg atattgatta caaagacgat       60

gacgataaga tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc      120

gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc      180

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      240

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      300

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      360

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      420

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      480

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      540

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      600

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      660

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      720

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      780

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      840

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      900

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      960

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg     1020

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg     1080

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1140

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1200

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1260

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1320

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1380

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1440

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1500

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1560

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1620

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1680

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1740

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1800

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1860

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1920

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1980

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     2040

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     2100

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2160

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2220

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2280

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2340

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2400

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2460

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2520

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2580

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2640

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2700

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2760

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2820

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2880

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2940

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     3000

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     3060

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3120

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3180

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3240

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3300

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3360

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3420

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3480

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3540

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3600

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3660

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3720

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3780

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3840

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3900

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3960

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     4020

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     4080

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4140

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4200

ctgtctcagc tgggaggcga caaaaggccg gcggccacga aaaaggccgg ccaggcaaaa     4260

aagaaaaagg gaagcggagc cactaacttc tccctgttga aacaagcagg ggatgtcgaa     4320

gagaatcccg ggcca                                                      4335


<210>  41
<211>  1445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cas9 adapted for mammalian expression

<400>  41

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu 
        35                  40                  45              


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    50                  55                  60                  


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
65                  70                  75                  80  


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                85                  90                  95      


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            100                 105                 110         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        115                 120                 125             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    130                 135                 140                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
145                 150                 155                 160 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                165                 170                 175     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            180                 185                 190         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        195                 200                 205             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    210                 215                 220                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
225                 230                 235                 240 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                245                 250                 255     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            260                 265                 270         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        275                 280                 285             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    290                 295                 300                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
305                 310                 315                 320 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                325                 330                 335     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            340                 345                 350         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        355                 360                 365             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    370                 375                 380                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
385                 390                 395                 400 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                405                 410                 415     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            420                 425                 430         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        435                 440                 445             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    450                 455                 460                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                485                 490                 495     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        515                 520                 525             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
545                 550                 555                 560 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                565                 570                 575     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            580                 585                 590         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        595                 600                 605             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    610                 615                 620                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                645                 650                 655     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            660                 665                 670         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        675                 680                 685             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    690                 695                 700                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
705                 710                 715                 720 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                725                 730                 735     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            740                 745                 750         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        755                 760                 765             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    770                 775                 780                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
785                 790                 795                 800 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                805                 810                 815     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            820                 825                 830         


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
        835                 840                 845             


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
    850                 855                 860                 


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
865                 870                 875                 880 


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
                885                 890                 895     


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
            900                 905                 910         


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
        915                 920                 925             


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
    930                 935                 940                 


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
                965                 970                 975     


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
            980                 985                 990         


Lys Val Ile Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
        995                 1000                 1005             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1010                 1015                 1020             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1040                 1045                 1050             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1055                 1060                 1065             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1070                 1075                 1080             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1085                 1090                 1095             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1100                 1105                 1110             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1115                 1120                 1125             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1130                 1135                 1140             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1160                 1165                 1170             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1175                 1180                 1185             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1190                 1195                 1200             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1205                 1210                 1215             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1220                 1225                 1230             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1235                 1240                 1245             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1250                 1255                 1260             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1265                 1270                 1275             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1280                 1285                 1290             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1295                 1300                 1305             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1310                 1315                 1320             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1325                 1330                 1335             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1340                 1345                 1350             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1355                 1360                 1365             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1370                 1375                 1380             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1385                 1390                 1395             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1400                 1405                 1410             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Gly Ser  Gly Ala Thr 
    1415                 1420                 1425             


Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro 
    1430                 1435                 1440             


Gly Pro  
    1445 


<210>  42
<211>  5052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-2A peptide-GFP cassette

<400>  42
atggactata aggaccacga cggagactac aaggatcatg atattgatta caaagacgat       60

gacgataaga tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc      120

gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc      180

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      240

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      300

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      360

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      420

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      480

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      540

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      600

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      660

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      720

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      780

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      840

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      900

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      960

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg     1020

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg     1080

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1140

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1200

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1260

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1320

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1380

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1440

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1500

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1560

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1620

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1680

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1740

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1800

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1860

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1920

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1980

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     2040

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     2100

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2160

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2220

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2280

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2340

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2400

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2460

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2520

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2580

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2640

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2700

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2760

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2820

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2880

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2940

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     3000

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     3060

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3120

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3180

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3240

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3300

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3360

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3420

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3480

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3540

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3600

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3660

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3720

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3780

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3840

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3900

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3960

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     4020

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     4080

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4140

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4200

ctgtctcagc tgggaggcga caaaaggccg gcggccacga aaaaggccgg ccaggcaaaa     4260

aagaaaaagg gaagcggagc cactaacttc tccctgttga aacaagcagg ggatgtcgaa     4320

gagaatcccg ggccagtgag caagggcgag gagctgttca ccggggtggt gcccatcctg     4380

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc     4440

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg     4500

ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc     4560

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag     4620

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag     4680

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac     4740

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac     4800

aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc     4860

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     4920

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc     4980

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     5040

ctgtacaagt aa                                                         5052


<210>  43
<211>  1683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cas9-2A peptide-GFP

<400>  43

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu 
        35                  40                  45              


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    50                  55                  60                  


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
65                  70                  75                  80  


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                85                  90                  95      


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            100                 105                 110         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        115                 120                 125             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    130                 135                 140                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
145                 150                 155                 160 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                165                 170                 175     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            180                 185                 190         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        195                 200                 205             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    210                 215                 220                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
225                 230                 235                 240 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                245                 250                 255     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            260                 265                 270         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        275                 280                 285             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    290                 295                 300                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
305                 310                 315                 320 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                325                 330                 335     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            340                 345                 350         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        355                 360                 365             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    370                 375                 380                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
385                 390                 395                 400 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                405                 410                 415     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            420                 425                 430         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        435                 440                 445             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    450                 455                 460                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                485                 490                 495     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        515                 520                 525             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
545                 550                 555                 560 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                565                 570                 575     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            580                 585                 590         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        595                 600                 605             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    610                 615                 620                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                645                 650                 655     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            660                 665                 670         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        675                 680                 685             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    690                 695                 700                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
705                 710                 715                 720 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                725                 730                 735     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            740                 745                 750         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        755                 760                 765             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    770                 775                 780                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
785                 790                 795                 800 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                805                 810                 815     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            820                 825                 830         


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
        835                 840                 845             


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
    850                 855                 860                 


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
865                 870                 875                 880 


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
                885                 890                 895     


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
            900                 905                 910         


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
        915                 920                 925             


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
    930                 935                 940                 


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
                965                 970                 975     


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
            980                 985                 990         


Lys Val Ile Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
        995                 1000                 1005             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1010                 1015                 1020             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1040                 1045                 1050             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1055                 1060                 1065             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1070                 1075                 1080             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1085                 1090                 1095             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1100                 1105                 1110             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1115                 1120                 1125             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1130                 1135                 1140             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1160                 1165                 1170             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1175                 1180                 1185             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1190                 1195                 1200             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1205                 1210                 1215             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1220                 1225                 1230             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1235                 1240                 1245             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1250                 1255                 1260             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1265                 1270                 1275             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1280                 1285                 1290             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1295                 1300                 1305             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1310                 1315                 1320             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1325                 1330                 1335             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1340                 1345                 1350             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1355                 1360                 1365             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1370                 1375                 1380             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1385                 1390                 1395             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1400                 1405                 1410             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Gly Ser  Gly Ala Thr 
    1415                 1420                 1425             


Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro 
    1430                 1435                 1440             


Gly Pro  Val Ser Lys Gly Glu  Glu Leu Phe Thr Gly  Val Val Pro 
    1445                 1450                 1455             


Ile Leu  Val Glu Leu Asp Gly  Asp Val Asn Gly His  Lys Phe Ser 
    1460                 1465                 1470             


Val Ser  Gly Glu Gly Glu Gly  Asp Ala Thr Tyr Gly  Lys Leu Thr 
    1475                 1480                 1485             


Leu Lys  Phe Ile Cys Thr Thr  Gly Lys Leu Pro Val  Pro Trp Pro 
    1490                 1495                 1500             


Thr Leu  Val Thr Thr Leu Thr  Tyr Gly Val Gln Cys  Phe Ser Arg 
    1505                 1510                 1515             


Tyr Pro  Asp His Met Lys Gln  His Asp Phe Phe Lys  Ser Ala Met 
    1520                 1525                 1530             


Pro Glu  Gly Tyr Val Gln Glu  Arg Thr Ile Phe Phe  Lys Asp Asp 
    1535                 1540                 1545             


Gly Asn  Tyr Lys Thr Arg Ala  Glu Val Lys Phe Glu  Gly Asp Thr 
    1550                 1555                 1560             


Leu Val  Asn Arg Ile Glu Leu  Lys Gly Ile Asp Phe  Lys Glu Asp 
    1565                 1570                 1575             


Gly Asn  Ile Leu Gly His Lys  Leu Glu Tyr Asn Tyr  Asn Ser His 
    1580                 1585                 1590             


Asn Val  Tyr Ile Met Ala Asp  Lys Gln Lys Asn Gly  Ile Lys Val 
    1595                 1600                 1605             


Asn Phe  Lys Ile Arg His Asn  Ile Glu Asp Gly Ser  Val Gln Leu 
    1610                 1615                 1620             


Ala Asp  His Tyr Gln Gln Asn  Thr Pro Ile Gly Asp  Gly Pro Val 
    1625                 1630                 1635             


Leu Leu  Pro Asp Asn His Tyr  Leu Ser Thr Gln Ser  Ala Leu Ser 
    1640                 1645                 1650             


Lys Asp  Pro Asn Glu Lys Arg  Asp His Met Val Leu  Leu Glu Phe 
    1655                 1660                 1665             


Val Thr  Ala Ala Gly Ile Thr  Leu Gly Met Asp Glu  Leu Tyr Lys 
    1670                 1675                 1680             


