                               SEQUENCE LISTING

<110> CODIAK BIOSCIENCES, INC.
 
<120> EXOSOMES FOR IMMUNO-ONCOLOGY AND ANTI-INFLAMMATORY THERAPY

<130> 32724-41775/WO

<140> PCT/US2018/068062
<141> 2018-12-28

<150> 62/723,267
<151> 2018-08-27

<150> 62/611,140
<151> 2017-12-28

<160> 26    

<170> PatentIn version 3.5

<210> 1
<211> 390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Ser Ala Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp 
        195                 200                 205             


Thr Pro Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile 
    210                 215                 220                 


Thr Val Glu Gly Ala Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val 
225                 230                 235                 240 


Ser Trp Phe Ala Val His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu 
                245                 250                 255     


Leu Ser Ser Leu Asp Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp 
            260                 265                 270         


Trp Lys Ser Asp Leu Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu 
        275                 280                 285             


Leu Gln Val His Gly Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys 
    290                 295                 300                 


Ser Val Thr Pro Trp Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu 
305                 310                 315                 320 


Ala Glu Ile His Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp Val 
                325                 330                 335     


Leu Asn Ala Phe Lys Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr 
            340                 345                 350         


Val Ile Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp 
        355                 360                 365             


Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu 
    370                 375                 380                 


Met Ser Met Glu Met Asp 
385                 390 


<210> 2
<211> 382
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Ile 
            180                 185                 190         


Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly Asp 
        195                 200                 205             


Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu Asp 
    210                 215                 220                 


Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser Phe 
225                 230                 235                 240 


Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys Gly 
                245                 250                 255     


Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu Glu 
            260                 265                 270         


Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu Asp 
        275                 280                 285             


Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys Ser 
    290                 295                 300                 


Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro Val 
305                 310                 315                 320 


Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro Leu 
                325                 330                 335     


Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys Leu 
            340                 345                 350         


Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln Glu 
        355                 360                 365             


Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp 
    370                 375                 380         


<210> 3
<211> 1418
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Arg 
            340                 345                 350         


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
        355                 360                 365             


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
    370                 375                 380                 


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
385                 390                 395                 400 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
                405                 410                 415     


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
            420                 425                 430         


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
        435                 440                 445             


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
    450                 455                 460                 


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
465                 470                 475                 480 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
                485                 490                 495     


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
            500                 505                 510         


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
        515                 520                 525             


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
    530                 535                 540                 


Leu Asn Ala Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Arg Val Val Arg Val Pro Thr Ala Thr Leu Val Arg Val Val Gly Thr 
                565                 570                 575     


Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu 
            580                 585                 590         


Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly Ser Ser Phe Val Glu 
        595                 600                 605             


Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu 
    610                 615                 620                 


Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala 
625                 630                 635                 640 


Val Glu Leu His Ile Lys Asn Val Gln Pro Ser Asp Gln Gly His Tyr 
                645                 650                 655     


Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu 
            660                 665                 670         


Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser Leu His Val Gly Pro 
        675                 680                 685             


Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe 
    690                 695                 700                 


Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro Leu His Thr His Leu 
705                 710                 715                 720 


Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala Arg Arg Ser Val Leu 
                725                 730                 735     


Ala Leu Thr His Glu Gly Arg Phe His Pro Gly Leu Gly Tyr Glu Gln 
            740                 745                 750         


Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr Val Gly Ser Asp Ala 
        755                 760                 765             


Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr 
    770                 775                 780                 


Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu 
785                 790                 795                 800 


Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro Ser 
                805                 810                 815     


Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly Lys 
            820                 825                 830         


Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp Val 
        835                 840                 845             


Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met Pro Asp Ser Thr Leu 
    850                 855                 860                 


Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg Asp Ser Leu Val His 
865                 870                 875                 880 


Ser Ser Pro His Val Ala Leu Ser His Val Asp Ala Arg Ser Tyr His 
                885                 890                 895     


Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys 
            900                 905                 910         


His Val Ser Leu Trp Ala Pro Gly His Asn Arg Ser Trp His Lys Val 
        915                 920                 925             


Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly Val Thr Trp Leu Glu 
    930                 935                 940                 


Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe Ala 
945                 950                 955                 960 


Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val Asp Thr Lys Ser Gly 
                965                 970                 975     


Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg 
            980                 985                 990         


Arg Ser Asp Asn Val Val Thr Ser  Glu Leu Leu Ala Val  Met Asp Gly 
        995                 1000                 1005             


Asp Trp  Thr Leu Lys Tyr Gly  Glu Arg Ser Lys Gln  Arg Ala Gln 
    1010                 1015                 1020             


Asp Gly  Asp Phe Ile Phe Ser  Lys Glu His Thr Asp  Thr Phe Asn 
    1025                 1030                 1035             


Phe Arg  Ile Gln Arg Thr Thr  Glu Glu Asp Arg Gly  Asn Tyr Tyr 
    1040                 1045                 1050             


Cys Val  Val Ser Ala Trp Thr  Lys Gln Arg Asn Asn  Ser Trp Val 
    1055                 1060                 1065             


Lys Ser  Lys Asp Val Phe Ser  Lys Pro Val Asn Ile  Phe Trp Ala 
    1070                 1075                 1080             


Leu Glu  Asp Ser Val Leu Val  Val Lys Ala Arg Gln  Pro Lys Pro 
    1085                 1090                 1095             


Phe Phe  Ala Ala Gly Asn Thr  Phe Glu Met Thr Cys  Lys Val Ser 
    1100                 1105                 1110             


Ser Lys  Asn Ile Lys Ser Pro  Arg Tyr Ser Val Leu  Ile Met Ala 
    1115                 1120                 1125             


Glu Lys  Pro Val Gly Asp Leu  Ser Ser Pro Asn Glu  Thr Lys Tyr 
    1130                 1135                 1140             


Ile Ile  Ser Leu Asp Gln Asp  Ser Val Val Lys Leu  Glu Asn Trp 
    1145                 1150                 1155             


Thr Asp  Ala Ser Arg Val Asp  Gly Val Val Leu Glu  Lys Val Gln 
    1160                 1165                 1170             


Glu Asp  Glu Phe Arg Tyr Arg  Met Tyr Gln Thr Gln  Val Ser Asp 
    1175                 1180                 1185             


Ala Gly  Leu Tyr Arg Cys Met  Val Thr Ala Trp Ser  Pro Val Arg 
    1190                 1195                 1200             


Gly Ser  Leu Trp Arg Glu Ala  Ala Thr Ser Leu Ser  Asn Pro Ile 
    1205                 1210                 1215             


Glu Ile  Asp Phe Gln Thr Ser  Gly Pro Ile Phe Asn  Ala Ser Val 
    1220                 1225                 1230             


His Ser  Asp Thr Pro Ser Val  Ile Arg Gly Asp Leu  Ile Lys Leu 
    1235                 1240                 1245             


Phe Cys  Ile Ile Thr Val Glu  Gly Ala Ala Leu Asp  Pro Asp Asp 
    1250                 1255                 1260             


Met Ala  Phe Asp Val Ser Trp  Phe Ala Val His Ser  Phe Gly Leu 
    1265                 1270                 1275             


Asp Lys  Ala Pro Val Leu Leu  Ser Ser Leu Asp Arg  Lys Gly Ile 
    1280                 1285                 1290             


Val Thr  Thr Ser Arg Arg Asp  Trp Lys Ser Asp Leu  Ser Leu Glu 
    1295                 1300                 1305             


Arg Val  Ser Val Leu Glu Phe  Leu Leu Gln Val His  Gly Ser Glu 
    1310                 1315                 1320             


Asp Gln  Asp Phe Gly Asn Tyr  Tyr Cys Ser Val Thr  Pro Trp Val 
    1325                 1330                 1335             


Lys Ser  Pro Thr Gly Ser Trp  Gln Lys Glu Ala Glu  Ile His Ser 
    1340                 1345                 1350             


Lys Pro  Val Phe Ile Thr Val  Lys Met Asp Val Leu  Asn Ala Phe 
    1355                 1360                 1365             


Lys Tyr  Pro Leu Leu Ile Gly  Val Gly Leu Ser Thr  Val Ile Gly 
    1370                 1375                 1380             


Leu Leu  Ser Cys Leu Ile Gly  Tyr Cys Ser Ser His  Trp Cys Cys 
    1385                 1390                 1395             


Lys Lys  Glu Val Gln Glu Thr  Arg Arg Glu Arg Arg  Arg Leu Met 
    1400                 1405                 1410             


Ser Met  Glu Met Asp 
    1415             


<210> 4
<211> 1421
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
        355                 360                 365             


Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
    370                 375                 380                 


Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
385                 390                 395                 400 


Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
                405                 410                 415     


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
            420                 425                 430         


Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
        435                 440                 445             


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
    450                 455                 460                 


Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
465                 470                 475                 480 


Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
                485                 490                 495     


Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
            500                 505                 510         


Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
        515                 520                 525             


Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
    530                 535                 540                 


Met Gly Tyr Leu Ser Ser Ala Ser Ala Gly Gly Gly Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Arg Val Val Arg Val Pro Thr Ala Thr Leu Val Arg Val 
                565                 570                 575     


Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr Asp Gly 
            580                 585                 590         


Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly Ser Ser 
        595                 600                 605             


Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala Gln Leu 
    610                 615                 620                 


Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg Thr Ala 
625                 630                 635                 640 


Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser Asp Gln 
                645                 650                 655     


Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val Gln Gly 
            660                 665                 670         


Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser Leu His 
        675                 680                 685             


Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly 
    690                 695                 700                 


Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro Leu His 
705                 710                 715                 720 


Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala Arg Arg 
                725                 730                 735     


Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly Leu Gly 
            740                 745                 750         


Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr Val Gly 
        755                 760                 765             


Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala Asp Gln 
    770                 775                 780                 


Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln Gly Asn 
785                 790                 795                 800 


Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val Val Ile 
                805                 810                 815     


Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser Val Ala 
            820                 825                 830         


Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala 
        835                 840                 845             


Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met Pro Asp 
    850                 855                 860                 


Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg Asp Ser 
865                 870                 875                 880 


Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp Ala Arg 
                885                 890                 895     


Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr 
            900                 905                 910         


Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg Ser Trp 
        915                 920                 925             


His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly Val Thr 
    930                 935                 940                 


Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val Pro 
945                 950                 955                 960 


Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val Asp Thr 
                965                 970                 975     


Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg 
            980                 985                 990         


Met Asn Arg Arg Ser Asp Asn Val  Val Thr Ser Glu Leu  Leu Ala Val 
        995                 1000                 1005             


Met Asp  Gly Asp Trp Thr Leu  Lys Tyr Gly Glu Arg  Ser Lys Gln 
    1010                 1015                 1020             


Arg Ala  Gln Asp Gly Asp Phe  Ile Phe Ser Lys Glu  His Thr Asp 
    1025                 1030                 1035             


Thr Phe  Asn Phe Arg Ile Gln  Arg Thr Thr Glu Glu  Asp Arg Gly 
    1040                 1045                 1050             


Asn Tyr  Tyr Cys Val Val Ser  Ala Trp Thr Lys Gln  Arg Asn Asn 
    1055                 1060                 1065             


Ser Trp  Val Lys Ser Lys Asp  Val Phe Ser Lys Pro  Val Asn Ile 
    1070                 1075                 1080             


Phe Trp  Ala Leu Glu Asp Ser  Val Leu Val Val Lys  Ala Arg Gln 
    1085                 1090                 1095             


Pro Lys  Pro Phe Phe Ala Ala  Gly Asn Thr Phe Glu  Met Thr Cys 
    1100                 1105                 1110             


Lys Val  Ser Ser Lys Asn Ile  Lys Ser Pro Arg Tyr  Ser Val Leu 
    1115                 1120                 1125             


Ile Met  Ala Glu Lys Pro Val  Gly Asp Leu Ser Ser  Pro Asn Glu 
    1130                 1135                 1140             


Thr Lys  Tyr Ile Ile Ser Leu  Asp Gln Asp Ser Val  Val Lys Leu 
    1145                 1150                 1155             


Glu Asn  Trp Thr Asp Ala Ser  Arg Val Asp Gly Val  Val Leu Glu 
    1160                 1165                 1170             


Lys Val  Gln Glu Asp Glu Phe  Arg Tyr Arg Met Tyr  Gln Thr Gln 
    1175                 1180                 1185             


Val Ser  Asp Ala Gly Leu Tyr  Arg Cys Met Val Thr  Ala Trp Ser 
    1190                 1195                 1200             


Pro Val  Arg Gly Ser Leu Trp  Arg Glu Ala Ala Thr  Ser Leu Ser 
    1205                 1210                 1215             


Asn Pro  Ile Glu Ile Asp Phe  Gln Thr Ser Gly Pro  Ile Phe Asn 
    1220                 1225                 1230             


Ala Ser  Val His Ser Asp Thr  Pro Ser Val Ile Arg  Gly Asp Leu 
    1235                 1240                 1245             


Ile Lys  Leu Phe Cys Ile Ile  Thr Val Glu Gly Ala  Ala Leu Asp 
    1250                 1255                 1260             


Pro Asp  Asp Met Ala Phe Asp  Val Ser Trp Phe Ala  Val His Ser 
    1265                 1270                 1275             


Phe Gly  Leu Asp Lys Ala Pro  Val Leu Leu Ser Ser  Leu Asp Arg 
    1280                 1285                 1290             


Lys Gly  Ile Val Thr Thr Ser  Arg Arg Asp Trp Lys  Ser Asp Leu 
    1295                 1300                 1305             


Ser Leu  Glu Arg Val Ser Val  Leu Glu Phe Leu Leu  Gln Val His 
    1310                 1315                 1320             


Gly Ser  Glu Asp Gln Asp Phe  Gly Asn Tyr Tyr Cys  Ser Val Thr 
    1325                 1330                 1335             


Pro Trp  Val Lys Ser Pro Thr  Gly Ser Trp Gln Lys  Glu Ala Glu 
    1340                 1345                 1350             


Ile His  Ser Lys Pro Val Phe  Ile Thr Val Lys Met  Asp Val Leu 
    1355                 1360                 1365             


Asn Ala  Phe Lys Tyr Pro Leu  Leu Ile Gly Val Gly  Leu Ser Thr 
    1370                 1375                 1380             


Val Ile  Gly Leu Leu Ser Cys  Leu Ile Gly Tyr Cys  Ser Ser His 
    1385                 1390                 1395             


Trp Cys  Cys Lys Lys Glu Val  Gln Glu Thr Arg Arg  Glu Arg Arg 
    1400                 1405                 1410             


Arg Leu  Met Ser Met Glu Met  Asp 
    1415                 1420     


<210> 5
<211> 753
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Ser Gly Gly Gly Ser Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Arg 
            340                 345                 350         


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
        355                 360                 365             


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
    370                 375                 380                 


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
385                 390                 395                 400 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
                405                 410                 415     


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
            420                 425                 430         


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
        435                 440                 445             


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
    450                 455                 460                 


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
465                 470                 475                 480 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
                485                 490                 495     


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
            500                 505                 510         


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
        515                 520                 525             


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
    530                 535                 540                 


Leu Asn Ala Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile 
                565                 570                 575     


Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala 
            580                 585                 590         


Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val 
        595                 600                 605             


His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp 
    610                 615                 620                 


Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu 
625                 630                 635                 640 


Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly 
                645                 650                 655     


Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp 
            660                 665                 670         


Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser 
        675                 680                 685             


Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys 
    690                 695                 700                 


Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu 
705                 710                 715                 720 


Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu 
                725                 730                 735     


Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met 
            740                 745                 750         


Asp 
    


<210> 6
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
        355                 360                 365             


Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
    370                 375                 380                 


Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
385                 390                 395                 400 


Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
                405                 410                 415     


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
            420                 425                 430         


Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
        435                 440                 445             


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
    450                 455                 460                 


Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
465                 470                 475                 480 


Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
                485                 490                 495     


Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
            500                 505                 510         


Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
        515                 520                 525             


Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
    530                 535                 540                 


Met Gly Tyr Leu Ser Ser Ala Ser Ala Gly Gly Gly Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro 
                565                 570                 575     


Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val 
            580                 585                 590         


Glu Gly Ala Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp 
        595                 600                 605             


Phe Ala Val His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser 
    610                 615                 620                 


Ser Leu Asp Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys 
625                 630                 635                 640 


Ser Asp Leu Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln 
                645                 650                 655     


Val His Gly Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val 
            660                 665                 670         


Thr Pro Trp Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu 
        675                 680                 685             


Ile His Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu Asn 
    690                 695                 700                 


Ala Phe Lys Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile 
705                 710                 715                 720 


Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys 
                725                 730                 735     


Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser 
            740                 745                 750         


Met Glu Met Asp 
        755     


<210> 7
<211> 1018
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu 
            20                  25                  30          


Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr 
        35                  40                  45              


Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys 
    50                  55                  60                  


Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn 
65                  70                  75                  80  


Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu 
                85                  90                  95      


Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp 
            100                 105                 110         


Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg 
        115                 120                 125             


Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala 
    130                 135                 140                 


Ala Lys Thr Gly Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Arg Val Val Arg Val Pro Thr Ala Thr Leu Val Arg Val Val Gly Thr 
                165                 170                 175     


Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu 
            180                 185                 190         


Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly Ser Ser Phe Val Glu 
        195                 200                 205             


Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu 
    210                 215                 220                 


Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala 
225                 230                 235                 240 


Val Glu Leu His Ile Lys Asn Val Gln Pro Ser Asp Gln Gly His Tyr 
                245                 250                 255     


Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu 
            260                 265                 270         


Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser Leu His Val Gly Pro 
        275                 280                 285             


Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe 
    290                 295                 300                 


Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro Leu His Thr His Leu 
305                 310                 315                 320 


Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala Arg Arg Ser Val Leu 
                325                 330                 335     


Ala Leu Thr His Glu Gly Arg Phe His Pro Gly Leu Gly Tyr Glu Gln 
            340                 345                 350         


Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr Val Gly Ser Asp Ala 
        355                 360                 365             


Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr 
    370                 375                 380                 


Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu 
385                 390                 395                 400 


Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro Ser 
                405                 410                 415     


Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly Lys 
            420                 425                 430         


Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp Val 
        435                 440                 445             


Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met Pro Asp Ser Thr Leu 
    450                 455                 460                 


Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg Asp Ser Leu Val His 
465                 470                 475                 480 


Ser Ser Pro His Val Ala Leu Ser His Val Asp Ala Arg Ser Tyr His 
                485                 490                 495     


Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys 
            500                 505                 510         


His Val Ser Leu Trp Ala Pro Gly His Asn Arg Ser Trp His Lys Val 
        515                 520                 525             


Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly Val Thr Trp Leu Glu 
    530                 535                 540                 


Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe Ala 
545                 550                 555                 560 


Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val Asp Thr Lys Ser Gly 
                565                 570                 575     


Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg 
            580                 585                 590         


Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu Ala Val Met Asp Gly 
        595                 600                 605             


Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp 
    610                 615                 620                 


Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp Thr Phe Asn Phe Arg 
625                 630                 635                 640 


Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val 
                645                 650                 655     


Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp Val Lys Ser Lys Asp 
            660                 665                 670         


Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala Leu Glu Asp Ser Val 
        675                 680                 685             


Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn 
    690                 695                 700                 


Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys Asn Ile Lys Ser Pro 
705                 710                 715                 720 


Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser 
                725                 730                 735     


Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val 
            740                 745                 750         


Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg Val Asp Gly Val Val 
        755                 760                 765             


Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr Arg Met Tyr Gln Thr 
    770                 775                 780                 


Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met Val Thr Ala Trp Ser 
785                 790                 795                 800 


Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn 
                805                 810                 815     


Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser 
            820                 825                 830         


Val His Ser Asp Thr Pro Ser Val Ile Arg Gly Asp Leu Ile Lys Leu 
        835                 840                 845             


Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu Asp Pro Asp Asp Met 
    850                 855                 860                 


Ala Phe Asp Val Ser Trp Phe Ala Val His Ser Phe Gly Leu Asp Lys 
865                 870                 875                 880 


Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys Gly Ile Val Thr Thr 
                885                 890                 895     


Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu Glu Arg Val Ser Val 
            900                 905                 910         


Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu Asp Gln Asp Phe Gly 
        915                 920                 925             


Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys Ser Pro Thr Gly Ser 
    930                 935                 940                 


Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro Val Phe Ile Thr Val 
945                 950                 955                 960 


Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro Leu Leu Ile Gly Val 
                965                 970                 975     


Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys 
            980                 985                 990         


Ser Ser His Trp Cys Cys Lys Lys  Glu Val Gln Glu Thr  Arg Arg Glu 
        995                 1000                 1005             


Arg Arg  Arg Leu Met Ser Met  Glu Met Asp 
    1010                 1015             


<210> 8
<211> 1157
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu 
            20                  25                  30          


Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr 
        35                  40                  45              


Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys 
    50                  55                  60                  


Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn 
65                  70                  75                  80  


Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu 
                85                  90                  95      


Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp 
            100                 105                 110         


Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg 
        115                 120                 125             


Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala 
    130                 135                 140                 


Ala Lys Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn 
                165                 170                 175     


Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile 
            180                 185                 190         


Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
        195                 200                 205             


Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln 
    210                 215                 220                 


Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys 
225                 230                 235                 240 


Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr 
                245                 250                 255     


Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu 
            260                 265                 270         


Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Ser 
        275                 280                 285             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Val Arg Val 
    290                 295                 300                 


Pro Thr Ala Thr Leu Val Arg Val Val Gly Thr Glu Leu Val Ile Pro 
305                 310                 315                 320 


Cys Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp 
                325                 330                 335     


Ser Phe Ser Ser Leu Gly Ser Ser Phe Val Glu Leu Ala Ser Thr Trp 
            340                 345                 350         


Glu Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly 
        355                 360                 365             


Glu Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala Val Glu Leu His Ile 
    370                 375                 380                 


Lys Asn Val Gln Pro Ser Asp Gln Gly His Tyr Lys Cys Ser Thr Pro 
385                 390                 395                 400 


Ser Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu Asp Thr Val Gln Val 
                405                 410                 415     


Lys Val Leu Ala Asp Ser Leu His Val Gly Pro Ser Ala Arg Pro Pro 
            420                 425                 430         


Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr 
        435                 440                 445             


Ala Ala Ser Ala Ser Pro Leu His Thr His Leu Ala Leu Leu Trp Glu 
    450                 455                 460                 


Val His Arg Gly Pro Ala Arg Arg Ser Val Leu Ala Leu Thr His Glu 
465                 470                 475                 480 


Gly Arg Phe His Pro Gly Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly 
                485                 490                 495     


Asp Val Arg Leu Asp Thr Val Gly Ser Asp Ala Tyr Arg Leu Ser Val 
            500                 505                 510         


Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser 
        515                 520                 525             


Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala 
    530                 535                 540                 


Val Glu Val Ala Thr Val Val Ile Gln Pro Ser Val Leu Arg Ala Ala 
545                 550                 555                 560 


Val Pro Lys Asn Val Ser Val Ala Glu Gly Lys Glu Leu Asp Leu Thr 
                565                 570                 575     


Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp Val Arg Pro Glu Val Thr 
            580                 585                 590         


Trp Ser Phe Ser Arg Met Pro Asp Ser Thr Leu Pro Gly Ser Arg Val 
        595                 600                 605             


Leu Ala Arg Leu Asp Arg Asp Ser Leu Val His Ser Ser Pro His Val 
    610                 615                 620                 


Ala Leu Ser His Val Asp Ala Arg Ser Tyr His Leu Leu Val Arg Asp 
625                 630                 635                 640 


Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp 
                645                 650                 655     


Ala Pro Gly His Asn Arg Ser Trp His Lys Val Ala Glu Ala Val Ser 
            660                 665                 670         


Ser Pro Ala Gly Val Gly Val Thr Trp Leu Glu Pro Asp Tyr Gln Val 
        675                 680                 685             


Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe Ala Asp Asp Pro Thr Glu 
    690                 695                 700                 


Leu Ala Cys Arg Val Val Asp Thr Lys Ser Gly Glu Ala Asn Val Arg 
705                 710                 715                 720 


Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp Asn Val 
                725                 730                 735     


Val Thr Ser Glu Leu Leu Ala Val Met Asp Gly Asp Trp Thr Leu Lys 
            740                 745                 750         


Tyr Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe 
        755                 760                 765             


Ser Lys Glu His Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr 
    770                 775                 780                 


Glu Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys 
785                 790                 795                 800 


Gln Arg Asn Asn Ser Trp Val Lys Ser Lys Asp Val Phe Ser Lys Pro 
                805                 810                 815     


Val Asn Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val Lys Ala 
            820                 825                 830         


Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu Met Thr 
        835                 840                 845             


Cys Lys Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu 
    850                 855                 860                 


Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn Glu Thr 
865                 870                 875                 880 


Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu Glu Asn 
                885                 890                 895     


Trp Thr Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys Val Gln 
            900                 905                 910         


Glu Asp Glu Phe Arg Tyr Arg Met Tyr Gln Thr Gln Val Ser Asp Ala 
        915                 920                 925             


Gly Leu Tyr Arg Cys Met Val Thr Ala Trp Ser Pro Val Arg Gly Ser 
    930                 935                 940                 


Leu Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp 
945                 950                 955                 960 


Phe Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr 
                965                 970                 975     


Pro Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr 
            980                 985                 990         


Val Glu Gly Ala Ala Leu Asp Pro  Asp Asp Met Ala Phe  Asp Val Ser 
        995                 1000                 1005             


Trp Phe  Ala Val His Ser Phe  Gly Leu Asp Lys Ala  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Ser Leu Asp Arg Lys  Gly Ile Val Thr Thr  Ser Arg Arg 
    1025                 1030                 1035             


Asp Trp  Lys Ser Asp Leu Ser  Leu Glu Arg Val Ser  Val Leu Glu 
    1040                 1045                 1050             


Phe Leu  Leu Gln Val His Gly  Ser Glu Asp Gln Asp  Phe Gly Asn 
    1055                 1060                 1065             


Tyr Tyr  Cys Ser Val Thr Pro  Trp Val Lys Ser Pro  Thr Gly Ser 
    1070                 1075                 1080             


Trp Gln  Lys Glu Ala Glu Ile  His Ser Lys Pro Val  Phe Ile Thr 
    1085                 1090                 1095             


Val Lys  Met Asp Val Leu Asn  Ala Phe Lys Tyr Pro  Leu Leu Ile 
    1100                 1105                 1110             


Gly Val  Gly Leu Ser Thr Val  Ile Gly Leu Leu Ser  Cys Leu Ile 
    1115                 1120                 1125             


Gly Tyr  Cys Ser Ser His Trp  Cys Cys Lys Lys Glu  Val Gln Glu 
    1130                 1135                 1140             


Thr Arg  Arg Glu Arg Arg Arg  Leu Met Ser Met Glu  Met Asp 
    1145                 1150                 1155         


<210> 9
<211> 1018
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Arg His Gly Thr Val Ile Glu Ser Leu Glu Ser 
            20                  25                  30          


Leu Asn Asn Tyr Phe Asn Ser Ser Gly Ile Asp Val Glu Glu Lys Ser 
        35                  40                  45              


Leu Phe Leu Asp Ile Trp Arg Asn Trp Gln Lys Asp Gly Asp Met Lys 
    50                  55                  60                  


Ile Leu Gln Ser Gln Ile Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val 
65                  70                  75                  80  


Leu Lys Asp Asn Gln Ala Ile Ser Asn Asn Ile Ser Val Ile Glu Ser 
                85                  90                  95      


His Leu Ile Thr Thr Phe Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala 
            100                 105                 110         


Phe Met Ser Ile Ala Lys Phe Glu Val Asn Asn Pro Gln Val Gln Arg 
        115                 120                 125             


Gln Ala Phe Asn Glu Leu Ile Arg Val Val His Gln Leu Leu Pro Glu 
    130                 135                 140                 


Ser Ser Leu Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Arg Val Val Arg Val Pro Thr Ala Thr Leu Val Arg Val Val Gly Thr 
                165                 170                 175     


Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu 
            180                 185                 190         


Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly Ser Ser Phe Val Glu 
        195                 200                 205             


Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu 
    210                 215                 220                 


Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala 
225                 230                 235                 240 


Val Glu Leu His Ile Lys Asn Val Gln Pro Ser Asp Gln Gly His Tyr 
                245                 250                 255     


Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu 
            260                 265                 270         


Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser Leu His Val Gly Pro 
        275                 280                 285             


Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe 
    290                 295                 300                 


Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro Leu His Thr His Leu 
305                 310                 315                 320 


Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala Arg Arg Ser Val Leu 
                325                 330                 335     


Ala Leu Thr His Glu Gly Arg Phe His Pro Gly Leu Gly Tyr Glu Gln 
            340                 345                 350         


Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr Val Gly Ser Asp Ala 
        355                 360                 365             


Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr 
    370                 375                 380                 


Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu 
385                 390                 395                 400 


Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro Ser 
                405                 410                 415     


Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly Lys 
            420                 425                 430         


Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp Val 
        435                 440                 445             


Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met Pro Asp Ser Thr Leu 
    450                 455                 460                 


Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg Asp Ser Leu Val His 
465                 470                 475                 480 


Ser Ser Pro His Val Ala Leu Ser His Val Asp Ala Arg Ser Tyr His 
                485                 490                 495     


Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys 
            500                 505                 510         


His Val Ser Leu Trp Ala Pro Gly His Asn Arg Ser Trp His Lys Val 
        515                 520                 525             


Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly Val Thr Trp Leu Glu 
    530                 535                 540                 


Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe Ala 
545                 550                 555                 560 


Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val Asp Thr Lys Ser Gly 
                565                 570                 575     


Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg 
            580                 585                 590         


Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu Ala Val Met Asp Gly 
        595                 600                 605             


Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp 
    610                 615                 620                 


Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp Thr Phe Asn Phe Arg 
625                 630                 635                 640 


Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val 
                645                 650                 655     


Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp Val Lys Ser Lys Asp 
            660                 665                 670         


Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala Leu Glu Asp Ser Val 
        675                 680                 685             


Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn 
    690                 695                 700                 


Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys Asn Ile Lys Ser Pro 
705                 710                 715                 720 


Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser 
                725                 730                 735     


Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val 
            740                 745                 750         


Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg Val Asp Gly Val Val 
        755                 760                 765             


Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr Arg Met Tyr Gln Thr 
    770                 775                 780                 


Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met Val Thr Ala Trp Ser 
785                 790                 795                 800 


Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn 
                805                 810                 815     


Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser 
            820                 825                 830         


Val His Ser Asp Thr Pro Ser Val Ile Arg Gly Asp Leu Ile Lys Leu 
        835                 840                 845             


Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu Asp Pro Asp Asp Met 
    850                 855                 860                 


Ala Phe Asp Val Ser Trp Phe Ala Val His Ser Phe Gly Leu Asp Lys 
865                 870                 875                 880 


Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys Gly Ile Val Thr Thr 
                885                 890                 895     


Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu Glu Arg Val Ser Val 
            900                 905                 910         


Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu Asp Gln Asp Phe Gly 
        915                 920                 925             


Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys Ser Pro Thr Gly Ser 
    930                 935                 940                 


Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro Val Phe Ile Thr Val 
945                 950                 955                 960 


Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro Leu Leu Ile Gly Val 
                965                 970                 975     


Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys 
            980                 985                 990         


Ser Ser His Trp Cys Cys Lys Lys  Glu Val Gln Glu Thr  Arg Arg Glu 
        995                 1000                 1005             


Arg Arg  Arg Leu Met Ser Met  Glu Met Asp 
    1010                 1015             


<210> 10
<211> 1156
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Arg His Gly Thr Val Ile Glu Ser Leu Glu Ser 
            20                  25                  30          


Leu Asn Asn Tyr Phe Asn Ser Ser Gly Ile Asp Val Glu Glu Lys Ser 
        35                  40                  45              


Leu Phe Leu Asp Ile Trp Arg Asn Trp Gln Lys Asp Gly Asp Met Lys 
    50                  55                  60                  


Ile Leu Gln Ser Gln Ile Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val 
65                  70                  75                  80  


Leu Lys Asp Asn Gln Ala Ile Ser Asn Asn Ile Ser Val Ile Glu Ser 
                85                  90                  95      


His Leu Ile Thr Thr Phe Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala 
            100                 105                 110         


Phe Met Ser Ile Ala Lys Phe Glu Val Asn Asn Pro Gln Val Gln Arg 
        115                 120                 125             


Gln Ala Phe Asn Glu Leu Ile Arg Val Val His Gln Leu Leu Pro Glu 
    130                 135                 140                 


Ser Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


His Gly Thr Val Ile Glu Ser Leu Glu Ser Leu Asn Asn Tyr Phe Asn 
                165                 170                 175     


Ser Ser Gly Ile Asp Val Glu Glu Lys Ser Leu Phe Leu Asp Ile Trp 
            180                 185                 190         


Arg Asn Trp Gln Lys Asp Gly Asp Met Lys Ile Leu Gln Ser Gln Ile 
        195                 200                 205             


Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val Leu Lys Asp Asn Gln Ala 
    210                 215                 220                 


Ile Ser Asn Asn Ile Ser Val Ile Glu Ser His Leu Ile Thr Thr Phe 
225                 230                 235                 240 


Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala Phe Met Ser Ile Ala Lys 
                245                 250                 255     


Phe Glu Val Asn Asn Pro Gln Val Gln Arg Gln Ala Phe Asn Glu Leu 
            260                 265                 270         


Ile Arg Val Val His Gln Leu Leu Pro Glu Ser Ser Leu Arg Ser Ala 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Val Arg Val Pro 
    290                 295                 300                 


Thr Ala Thr Leu Val Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys 
305                 310                 315                 320 


Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser 
                325                 330                 335     


Phe Ser Ser Leu Gly Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu 
            340                 345                 350         


Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu 
        355                 360                 365             


Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys 
    370                 375                 380                 


Asn Val Gln Pro Ser Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser 
385                 390                 395                 400 


Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys 
                405                 410                 415     


Val Leu Ala Asp Ser Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro 
            420                 425                 430         


Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala 
        435                 440                 445             


Ala Ser Ala Ser Pro Leu His Thr His Leu Ala Leu Leu Trp Glu Val 
    450                 455                 460                 


His Arg Gly Pro Ala Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly 
465                 470                 475                 480 


Arg Phe His Pro Gly Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp 
                485                 490                 495     


Val Arg Leu Asp Thr Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser 
            500                 505                 510         


Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu 
        515                 520                 525             


Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val 
    530                 535                 540                 


Glu Val Ala Thr Val Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val 
545                 550                 555                 560 


Pro Lys Asn Val Ser Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys 
                565                 570                 575     


Asn Ile Thr Thr Asp Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp 
            580                 585                 590         


Ser Phe Ser Arg Met Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu 
        595                 600                 605             


Ala Arg Leu Asp Arg Asp Ser Leu Val His Ser Ser Pro His Val Ala 
    610                 615                 620                 


Leu Ser His Val Asp Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val 
625                 630                 635                 640 


Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala 
                645                 650                 655     


Pro Gly His Asn Arg Ser Trp His Lys Val Ala Glu Ala Val Ser Ser 
            660                 665                 670         


Pro Ala Gly Val Gly Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr 
        675                 680                 685             


Leu Asn Ala Ser Lys Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu 
    690                 695                 700                 


Ala Cys Arg Val Val Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe 
705                 710                 715                 720 


Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val 
                725                 730                 735     


Thr Ser Glu Leu Leu Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr 
            740                 745                 750         


Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser 
        755                 760                 765             


Lys Glu His Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu 
    770                 775                 780                 


Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln 
785                 790                 795                 800 


Arg Asn Asn Ser Trp Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val 
                805                 810                 815     


Asn Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg 
            820                 825                 830         


Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys 
        835                 840                 845             


Lys Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile 
    850                 855                 860                 


Met Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys 
865                 870                 875                 880 


Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp 
                885                 890                 895     


Thr Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys Val Gln Glu 
            900                 905                 910         


Asp Glu Phe Arg Tyr Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly 
        915                 920                 925             


Leu Tyr Arg Cys Met Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu 
    930                 935                 940                 


Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe 
945                 950                 955                 960 


Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro 
                965                 970                 975     


Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val 
            980                 985                 990         


Glu Gly Ala Ala Leu Asp Pro Asp  Asp Met Ala Phe Asp  Val Ser Trp 
        995                 1000                 1005             


Phe Ala  Val His Ser Phe Gly  Leu Asp Lys Ala Pro  Val Leu Leu 
    1010                 1015                 1020             


Ser Ser  Leu Asp Arg Lys Gly  Ile Val Thr Thr Ser  Arg Arg Asp 
    1025                 1030                 1035             


Trp Lys  Ser Asp Leu Ser Leu  Glu Arg Val Ser Val  Leu Glu Phe 
    1040                 1045                 1050             


Leu Leu  Gln Val His Gly Ser  Glu Asp Gln Asp Phe  Gly Asn Tyr 
    1055                 1060                 1065             


Tyr Cys  Ser Val Thr Pro Trp  Val Lys Ser Pro Thr  Gly Ser Trp 
    1070                 1075                 1080             


Gln Lys  Glu Ala Glu Ile His  Ser Lys Pro Val Phe  Ile Thr Val 
    1085                 1090                 1095             


Lys Met  Asp Val Leu Asn Ala  Phe Lys Tyr Pro Leu  Leu Ile Gly 
    1100                 1105                 1110             


Val Gly  Leu Ser Thr Val Ile  Gly Leu Leu Ser Cys  Leu Ile Gly 
    1115                 1120                 1125             


Tyr Cys  Ser Ser His Trp Cys  Cys Lys Lys Glu Val  Gln Glu Thr 
    1130                 1135                 1140             


Arg Arg  Glu Arg Arg Arg Leu  Met Ser Met Glu Met  Asp 
    1145                 1150                 1155     


<210> 11
<211> 422
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
225                 230                 235                 240 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                245                 250                 255     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            260                 265                 270         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        275                 280                 285             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    290                 295                 300                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
305                 310                 315                 320 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                325                 330                 335     


Gln Met Phe Ile Asn Thr Ser Ser Ala Asp Tyr Lys Asp Asp Asp Asp 
            340                 345                 350         


Lys Phe Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Gly 
        355                 360                 365             


Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys 
    370                 375                 380                 


Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile 
385                 390                 395                 400 


Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg Ser Gly 
                405                 410                 415     


Leu Leu Thr Gly Arg Thr 
            420         


<210> 12
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly His His 
            20                  25                  30          


His His His His Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        35                  40                  45              


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    50                  55                  60                  


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
65                  70                  75                  80  


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                85                  90                  95      


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
            100                 105                 110         


Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu 
        115                 120                 125             


Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn 
    130                 135                 140                 


Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro 
145                 150                 155                 160 


Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser 
                165                 170                 175     


Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr 
            180                 185                 190         


Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser 
        195                 200                 205             


Asp Thr Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    210                 215                 220                 


Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro Asn Asp Lys Tyr Glu 
225                 230                 235                 240 


Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Ser Asn Trp Val Asn Val Ile Ser Asp Leu 
            260                 265                 270         


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
        275                 280                 285             


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
    290                 295                 300                 


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
305                 310                 315                 320 


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
                325                 330                 335     


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
            340                 345                 350         


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
        355                 360                 365             


Ile Val Gln Met Phe Ile Asn Thr Ser Ser Ala Asp Tyr Lys Asp Asp 
    370                 375                 380                 


Asp Asp Lys Phe Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
385                 390                 395                 400 


Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
                405                 410                 415     


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
            420                 425                 430         


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
        435                 440                 445             


Ser Gly Leu Leu Thr Gly Arg Thr 
    450                 455     


<210> 13
<211> 412
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Ser Ala Asp 
                325                 330                 335     


Tyr Lys Asp Asp Asp Asp Lys Phe Glu Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro 
        355                 360                 365             


His Ser Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu 
    370                 375                 380                 


Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln 
385                 390                 395                 400 


Lys Lys Pro Arg Ser Gly Leu Leu Thr Gly Arg Thr 
                405                 410         


<210> 14
<211> 446
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Leu Asp Pro Arg Ser 
145                 150                 155                 160 


Phe Leu Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp 
                165                 170                 175     


Glu Glu Lys Asn Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
        195                 200                 205             


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
    210                 215                 220                 


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
225                 230                 235                 240 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
                245                 250                 255     


Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
            260                 265                 270         


Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro 
        275                 280                 285             


Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala 
    290                 295                 300                 


Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys 
305                 310                 315                 320 


Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His 
                325                 330                 335     


Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser 
            340                 345                 350         


Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr 
        355                 360                 365             


Thr Ser Ala Phe Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
    370                 375                 380                 


Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
385                 390                 395                 400 


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
                405                 410                 415     


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
            420                 425                 430         


Ser Gly Leu Leu Thr Gly Arg Thr His His His His His His 
        435                 440                 445     


<210> 15
<211> 1239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser Ala Gly Thr Thr Gly 
145                 150                 155                 160 


Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr Ala Gly Ala Ser Ser 
            180                 185                 190         


Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
        195                 200                 205             


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
    210                 215                 220                 


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
225                 230                 235                 240 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
                245                 250                 255     


Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
            260                 265                 270         


Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro 
        275                 280                 285             


Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala 
    290                 295                 300                 


Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys 
305                 310                 315                 320 


Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His 
                325                 330                 335     


Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser 
            340                 345                 350         


Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr 
        355                 360                 365             


Thr Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Val 
    370                 375                 380                 


Arg Val Pro Thr Ala Thr Leu Val Arg Val Val Gly Thr Glu Leu Val 
385                 390                 395                 400 


Ile Pro Cys Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu Gln Asn Phe 
                405                 410                 415     


Asp Trp Ser Phe Ser Ser Leu Gly Ser Ser Phe Val Glu Leu Ala Ser 
            420                 425                 430         


Thr Trp Glu Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu Arg Leu Gln 
        435                 440                 445             


Arg Gly Glu Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala Val Glu Leu 
    450                 455                 460                 


His Ile Lys Asn Val Gln Pro Ser Asp Gln Gly His Tyr Lys Cys Ser 
465                 470                 475                 480 


Thr Pro Ser Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu Asp Thr Val 
                485                 490                 495     


Gln Val Lys Val Leu Ala Asp Ser Leu His Val Gly Pro Ser Ala Arg 
            500                 505                 510         


Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe Glu Leu Arg 
        515                 520                 525             


Cys Thr Ala Ala Ser Ala Ser Pro Leu His Thr His Leu Ala Leu Leu 
    530                 535                 540                 


Trp Glu Val His Arg Gly Pro Ala Arg Arg Ser Val Leu Ala Leu Thr 
545                 550                 555                 560 


His Glu Gly Arg Phe His Pro Gly Leu Gly Tyr Glu Gln Arg Tyr His 
                565                 570                 575     


Ser Gly Asp Val Arg Leu Asp Thr Val Gly Ser Asp Ala Tyr Arg Leu 
            580                 585                 590         


Ser Val Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr Arg Cys Ile 
        595                 600                 605             


Val Ser Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu Ile Gln Glu 
    610                 615                 620                 


Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro Ser Val Leu Arg 
625                 630                 635                 640 


Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly Lys Glu Leu Asp 
                645                 650                 655     


Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp Val Arg Pro Glu 
            660                 665                 670         


Val Thr Trp Ser Phe Ser Arg Met Pro Asp Ser Thr Leu Pro Gly Ser 
        675                 680                 685             


Arg Val Leu Ala Arg Leu Asp Arg Asp Ser Leu Val His Ser Ser Pro 
    690                 695                 700                 


His Val Ala Leu Ser His Val Asp Ala Arg Ser Tyr His Leu Leu Val 
705                 710                 715                 720 


Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser 
                725                 730                 735     


Leu Trp Ala Pro Gly His Asn Arg Ser Trp His Lys Val Ala Glu Ala 
            740                 745                 750         


Val Ser Ser Pro Ala Gly Val Gly Val Thr Trp Leu Glu Pro Asp Tyr 
        755                 760                 765             


Gln Val Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe Ala Asp Asp Pro 
    770                 775                 780                 


Thr Glu Leu Ala Cys Arg Val Val Asp Thr Lys Ser Gly Glu Ala Asn 
785                 790                 795                 800 


Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp 
                805                 810                 815     


Asn Val Val Thr Ser Glu Leu Leu Ala Val Met Asp Gly Asp Trp Thr 
            820                 825                 830         


Leu Lys Tyr Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe 
        835                 840                 845             


Ile Phe Ser Lys Glu His Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg 
    850                 855                 860                 


Thr Thr Glu Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val Ser Ala Trp 
865                 870                 875                 880 


Thr Lys Gln Arg Asn Asn Ser Trp Val Lys Ser Lys Asp Val Phe Ser 
                885                 890                 895     


Lys Pro Val Asn Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val 
            900                 905                 910         


Lys Ala Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu 
        915                 920                 925             


Met Thr Cys Lys Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser 
    930                 935                 940                 


Val Leu Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu 
                965                 970                 975     


Glu Asn Trp Thr Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys 
            980                 985                 990         


Val Gln Glu Asp Glu Phe Arg Tyr  Arg Met Tyr Gln Thr  Gln Val Ser 
        995                 1000                 1005             


Asp Ala  Gly Leu Tyr Arg Cys  Met Val Thr Ala Trp  Ser Pro Val 
    1010                 1015                 1020             


Arg Gly  Ser Leu Trp Arg Glu  Ala Ala Thr Ser Leu  Ser Asn Pro 
    1025                 1030                 1035             


Ile Glu  Ile Asp Phe Gln Thr  Ser Gly Pro Ile Phe  Asn Ala Ser 
    1040                 1045                 1050             


Val His  Ser Asp Thr Pro Ser  Val Ile Arg Gly Asp  Leu Ile Lys 
    1055                 1060                 1065             


Leu Phe  Cys Ile Ile Thr Val  Glu Gly Ala Ala Leu  Asp Pro Asp 
    1070                 1075                 1080             


Asp Met  Ala Phe Asp Val Ser  Trp Phe Ala Val His  Ser Phe Gly 
    1085                 1090                 1095             


Leu Asp  Lys Ala Pro Val Leu  Leu Ser Ser Leu Asp  Arg Lys Gly 
    1100                 1105                 1110             


Ile Val  Thr Thr Ser Arg Arg  Asp Trp Lys Ser Asp  Leu Ser Leu 
    1115                 1120                 1125             


Glu Arg  Val Ser Val Leu Glu  Phe Leu Leu Gln Val  His Gly Ser 
    1130                 1135                 1140             


Glu Asp  Gln Asp Phe Gly Asn  Tyr Tyr Cys Ser Val  Thr Pro Trp 
    1145                 1150                 1155             


Val Lys  Ser Pro Thr Gly Ser  Trp Gln Lys Glu Ala  Glu Ile His 
    1160                 1165                 1170             


Ser Lys  Pro Val Phe Ile Thr  Val Lys Met Asp Val  Leu Asn Ala 
    1175                 1180                 1185             


Phe Lys  Tyr Pro Leu Leu Ile  Gly Val Gly Leu Ser  Thr Val Ile 
    1190                 1195                 1200             


Gly Leu  Leu Ser Cys Leu Ile  Gly Tyr Cys Ser Ser  His Trp Cys 
    1205                 1210                 1215             


Cys Lys  Lys Glu Val Gln Glu  Thr Arg Arg Glu Arg  Arg Arg Leu 
    1220                 1225                 1230             


Met Ser  Met Glu Met Asp 
    1235                 


<210> 16
<211> 1239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser Ala Gly Thr Thr Gly 
145                 150                 155                 160 


Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr Ala Gly Ala Ser Ser 
            180                 185                 190         


Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
        195                 200                 205             


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
    210                 215                 220                 


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
225                 230                 235                 240 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
                245                 250                 255     


Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
            260                 265                 270         


Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro 
        275                 280                 285             


Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala 
    290                 295                 300                 


Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys 
305                 310                 315                 320 


Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His 
                325                 330                 335     


Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser 
            340                 345                 350         


Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr 
        355                 360                 365             


Thr Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Val 
    370                 375                 380                 


Arg Val Pro Thr Ala Thr Leu Val Arg Val Val Gly Thr Glu Leu Val 
385                 390                 395                 400 


Ile Pro Cys Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu Gln Asn Phe 
                405                 410                 415     


Asp Trp Ser Phe Ser Ser Leu Gly Ser Ser Phe Val Glu Leu Ala Ser 
            420                 425                 430         


Thr Trp Glu Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu Arg Leu Gln 
        435                 440                 445             


Arg Gly Glu Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala Val Glu Leu 
    450                 455                 460                 


His Ile Lys Asn Val Gln Pro Ser Asp Gln Gly His Tyr Lys Cys Ser 
465                 470                 475                 480 


Thr Pro Ser Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu Asp Thr Val 
                485                 490                 495     


Gln Val Lys Val Leu Ala Asp Ser Leu His Val Gly Pro Ser Ala Arg 
            500                 505                 510         


Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe Glu Leu Arg 
        515                 520                 525             


Cys Thr Ala Ala Ser Ala Ser Pro Leu His Thr His Leu Ala Leu Leu 
    530                 535                 540                 


Trp Glu Val His Arg Gly Pro Ala Arg Arg Ser Val Leu Ala Leu Thr 
545                 550                 555                 560 


His Glu Gly Arg Phe His Pro Gly Leu Gly Tyr Glu Gln Arg Tyr His 
                565                 570                 575     


Ser Gly Asp Val Arg Leu Asp Thr Val Gly Ser Asp Ala Tyr Arg Leu 
            580                 585                 590         


Ser Val Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr Arg Cys Ile 
        595                 600                 605             


Val Ser Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu Ile Gln Glu 
    610                 615                 620                 


Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro Ser Val Leu Arg 
625                 630                 635                 640 


Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly Lys Glu Leu Asp 
                645                 650                 655     


Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp Val Arg Pro Glu 
            660                 665                 670         


Val Thr Trp Ser Phe Ser Arg Met Pro Asp Ser Thr Leu Pro Gly Ser 
        675                 680                 685             


Arg Val Leu Ala Arg Leu Asp Arg Asp Ser Leu Val His Ser Ser Pro 
    690                 695                 700                 


His Val Ala Leu Ser His Val Asp Ala Arg Ser Tyr His Leu Leu Val 
705                 710                 715                 720 


Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser 
                725                 730                 735     


Leu Trp Ala Pro Gly His Asn Arg Ser Trp His Lys Val Ala Glu Ala 
            740                 745                 750         


Val Ser Ser Pro Ala Gly Val Gly Val Thr Trp Leu Glu Pro Asp Tyr 
        755                 760                 765             


Gln Val Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe Ala Asp Asp Pro 
    770                 775                 780                 


Thr Glu Leu Ala Cys Arg Val Val Asp Thr Lys Ser Gly Glu Ala Asn 
785                 790                 795                 800 


Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp 
                805                 810                 815     


Asn Val Val Thr Ser Glu Leu Leu Ala Val Met Asp Gly Asp Trp Thr 
            820                 825                 830         


Leu Lys Tyr Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe 
        835                 840                 845             


Ile Phe Ser Lys Glu His Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg 
    850                 855                 860                 


Thr Thr Glu Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val Ser Ala Trp 
865                 870                 875                 880 


Thr Lys Gln Arg Asn Asn Ser Trp Val Lys Ser Lys Asp Val Phe Ser 
                885                 890                 895     


Lys Pro Val Asn Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val 
            900                 905                 910         


Lys Ala Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu 
        915                 920                 925             


Met Thr Cys Lys Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser 
    930                 935                 940                 


Val Leu Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn 
945                 950                 955                 960 


Glu Thr Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu 
                965                 970                 975     


Glu Asn Trp Thr Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys 
            980                 985                 990         


Val Gln Glu Asp Glu Phe Arg Tyr  Arg Met Tyr Gln Thr  Gln Val Ser 
        995                 1000                 1005             


Asp Ala  Gly Leu Tyr Arg Cys  Met Val Thr Ala Trp  Ser Pro Val 
    1010                 1015                 1020             


Arg Gly  Ser Leu Trp Arg Glu  Ala Ala Thr Ser Leu  Ser Asn Pro 
    1025                 1030                 1035             


Ile Glu  Ile Asp Phe Gln Thr  Ser Gly Pro Ile Phe  Asn Ala Ser 
    1040                 1045                 1050             


Val His  Ser Asp Thr Pro Ser  Val Ile Arg Gly Asp  Leu Ile Lys 
    1055                 1060                 1065             


Leu Phe  Cys Ile Ile Thr Val  Glu Gly Ala Ala Leu  Asp Pro Asp 
    1070                 1075                 1080             


Asp Met  Ala Phe Asp Val Ser  Trp Phe Ala Val His  Ser Phe Gly 
    1085                 1090                 1095             


Leu Asp  Lys Ala Pro Val Leu  Leu Ser Ser Leu Asp  Arg Lys Gly 
    1100                 1105                 1110             


Ile Val  Thr Thr Ser Arg Arg  Asp Trp Lys Ser Asp  Leu Ser Leu 
    1115                 1120                 1125             


Glu Arg  Val Ser Val Leu Glu  Phe Leu Leu Gln Val  His Gly Ser 
    1130                 1135                 1140             


Glu Asp  Gln Asp Phe Gly Asn  Tyr Tyr Cys Ser Val  Thr Pro Trp 
    1145                 1150                 1155             


Val Lys  Ser Pro Thr Gly Ser  Trp Gln Lys Glu Ala  Glu Ile His 
    1160                 1165                 1170             


Ser Lys  Pro Val Phe Ile Thr  Val Lys Met Asp Val  Leu Asn Ala 
    1175                 1180                 1185             


Phe Lys  Tyr Pro Leu Leu Ile  Gly Val Gly Leu Ser  Thr Val Ile 
    1190                 1195                 1200             


Gly Leu  Leu Ser Cys Leu Ile  Gly Tyr Cys Ser Ser  His Trp Cys 
    1205                 1210                 1215             


Cys Lys  Lys Glu Val Gln Glu  Thr Arg Arg Glu Arg  Arg Arg Leu 
    1220                 1225                 1230             


Met Ser  Met Glu Met Asp 
    1235                 


<210> 17
<211> 602
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Lys Ile Ile Cys Leu Ala Leu Val Ala Leu Leu Leu Thr Ala Gln 
1               5                   10                  15      


Pro Ala Met Ala Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Ser Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser 
                245                 250                 255     


Ala Gly Thr Thr Gly Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr 
        275                 280                 285             


Ala Gly Ala Ser Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Lys Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys 
            340                 345                 350         


Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    370                 375                 380                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe 
385                 390                 395                 400 


Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            420                 425                 430         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                485                 490                 495     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Ser Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser 
545                 550                 555                 560 


Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val 
                565                 570                 575     


Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys 
            580                 585                 590         


Pro Arg Asp Tyr Lys Asp Asp Asp Asp Lys 
        595                 600         


<210> 18
<211> 1656
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Lys Ile Ile Cys Leu Ala Leu Val Ala Leu Leu Leu Thr Ala Gln 
1               5                   10                  15      


Pro Ala Met Ala Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Ser Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser 
                245                 250                 255     


Ala Gly Thr Thr Gly Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr 
        275                 280                 285             


Ala Gly Ala Ser Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Lys Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys 
            340                 345                 350         


Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    370                 375                 380                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe 
385                 390                 395                 400 


Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            420                 425                 430         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                485                 490                 495     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Ser Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Arg Val Val Arg Val Pro Thr Ala Thr Leu Val Arg Val Val Gly 
545                 550                 555                 560 


Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr Asp Gly Pro Ser 
                565                 570                 575     


Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly Ser Ser Phe Val 
            580                 585                 590         


Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala Gln Leu Tyr Gln 
        595                 600                 605             


Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg Thr Ala Asn Asp 
    610                 615                 620                 


Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser Asp Gln Gly His 
625                 630                 635                 640 


Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val Gln Gly Asn Tyr 
                645                 650                 655     


Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser Leu His Val Gly 
            660                 665                 670         


Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro 
        675                 680                 685             


Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro Leu His Thr His 
    690                 695                 700                 


Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala Arg Arg Ser Val 
705                 710                 715                 720 


Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly Leu Gly Tyr Glu 
                725                 730                 735     


Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr Val Gly Ser Asp 
            740                 745                 750         


Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser 
        755                 760                 765             


Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln 
    770                 775                 780                 


Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro 
785                 790                 795                 800 


Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly 
                805                 810                 815     


Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp 
            820                 825                 830         


Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met Pro Asp Ser Thr 
        835                 840                 845             


Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg Asp Ser Leu Val 
    850                 855                 860                 


His Ser Ser Pro His Val Ala Leu Ser His Val Asp Ala Arg Ser Tyr 
865                 870                 875                 880 


His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr 
                885                 890                 895     


Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg Ser Trp His Lys 
            900                 905                 910         


Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly Val Thr Trp Leu 
        915                 920                 925             


Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe 
    930                 935                 940                 


Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val Asp Thr Lys Ser 
945                 950                 955                 960 


Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn 
                965                 970                 975     


Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu Ala Val Met Asp 
            980                 985                 990         


Gly Asp Trp Thr Leu Lys Tyr Gly  Glu Arg Ser Lys Gln  Arg Ala Gln 
        995                 1000                 1005             


Asp Gly  Asp Phe Ile Phe Ser  Lys Glu His Thr Asp  Thr Phe Asn 
    1010                 1015                 1020             


Phe Arg  Ile Gln Arg Thr Thr  Glu Glu Asp Arg Gly  Asn Tyr Tyr 
    1025                 1030                 1035             


Cys Val  Val Ser Ala Trp Thr  Lys Gln Arg Asn Asn  Ser Trp Val 
    1040                 1045                 1050             


Lys Ser  Lys Asp Val Phe Ser  Lys Pro Val Asn Ile  Phe Trp Ala 
    1055                 1060                 1065             


Leu Glu  Asp Ser Val Leu Val  Val Lys Ala Arg Gln  Pro Lys Pro 
    1070                 1075                 1080             


Phe Phe  Ala Ala Gly Asn Thr  Phe Glu Met Thr Cys  Lys Val Ser 
    1085                 1090                 1095             


Ser Lys  Asn Ile Lys Ser Pro  Arg Tyr Ser Val Leu  Ile Met Ala 
    1100                 1105                 1110             


Glu Lys  Pro Val Gly Asp Leu  Ser Ser Pro Asn Glu  Thr Lys Tyr 
    1115                 1120                 1125             


Ile Ile  Ser Leu Asp Gln Asp  Ser Val Val Lys Leu  Glu Asn Trp 
    1130                 1135                 1140             


Thr Asp  Ala Ser Arg Val Asp  Gly Val Val Leu Glu  Lys Val Gln 
    1145                 1150                 1155             


Glu Asp  Glu Phe Arg Tyr Arg  Met Tyr Gln Thr Gln  Val Ser Asp 
    1160                 1165                 1170             


Ala Gly  Leu Tyr Arg Cys Met  Val Thr Ala Trp Ser  Pro Val Arg 
    1175                 1180                 1185             


Gly Ser  Leu Trp Arg Glu Ala  Ala Thr Ser Leu Ser  Asn Pro Ile 
    1190                 1195                 1200             


Glu Ile  Asp Phe Gln Thr Ser  Gly Pro Ile Phe Asn  Ala Ser Val 
    1205                 1210                 1215             


His Ser  Asp Thr Pro Ser Val  Ile Arg Gly Asp Leu  Ile Lys Leu 
    1220                 1225                 1230             


Phe Cys  Ile Ile Thr Val Glu  Gly Ala Ala Leu Asp  Pro Asp Asp 
    1235                 1240                 1245             


Met Ala  Phe Asp Val Ser Trp  Phe Ala Val His Ser  Phe Gly Leu 
    1250                 1255                 1260             


Asp Lys  Ala Pro Val Leu Leu  Ser Ser Leu Asp Arg  Lys Gly Ile 
    1265                 1270                 1275             


Val Thr  Thr Ser Arg Arg Asp  Trp Lys Ser Asp Leu  Ser Leu Glu 
    1280                 1285                 1290             


Arg Val  Ser Val Leu Glu Phe  Leu Leu Gln Val His  Gly Ser Glu 
    1295                 1300                 1305             


Asp Gln  Asp Phe Gly Asn Tyr  Tyr Cys Ser Val Thr  Pro Trp Val 
    1310                 1315                 1320             


Lys Ser  Pro Thr Gly Ser Trp  Gln Lys Glu Ala Glu  Ile His Ser 
    1325                 1330                 1335             


Lys Pro  Val Phe Ile Thr Val  Lys Met Asp Val Leu  Asn Ala Phe 
    1340                 1345                 1350             


Lys Tyr  Pro Leu Leu Ile Gly  Val Gly Leu Ser Thr  Val Ile Gly 
    1355                 1360                 1365             


Leu Leu  Ser Cys Leu Ile Gly  Tyr Cys Ser Ser His  Trp Cys Cys 
    1370                 1375                 1380             


Lys Lys  Glu Val Gln Glu Thr  Arg Arg Glu Arg Arg  Arg Leu Met 
    1385                 1390                 1395             


Ser Met  Glu Met Asp Thr Gly  Gly Ser Gly Gly Ser  Val Ser Lys 
    1400                 1405                 1410             


Gly Glu  Glu Leu Phe Thr Gly  Val Val Pro Ile Leu  Val Glu Leu 
    1415                 1420                 1425             


Asp Gly  Asp Val Asn Gly His  Lys Phe Ser Val Ser  Gly Glu Gly 
    1430                 1435                 1440             


Glu Gly  Asp Ala Thr Tyr Gly  Lys Leu Thr Leu Lys  Phe Ile Cys 
    1445                 1450                 1455             


Thr Thr  Gly Lys Leu Pro Val  Pro Trp Pro Thr Leu  Val Thr Thr 
    1460                 1465                 1470             


Leu Thr  Tyr Gly Val Gln Cys  Phe Ser Arg Tyr Pro  Asp His Met 
    1475                 1480                 1485             


Lys Gln  His Asp Phe Phe Lys  Ser Ala Met Pro Glu  Gly Tyr Val 
    1490                 1495                 1500             


Gln Glu  Arg Thr Ile Phe Phe  Lys Asp Asp Gly Asn  Tyr Lys Thr 
    1505                 1510                 1515             


Arg Ala  Glu Val Lys Phe Glu  Gly Asp Thr Leu Val  Asn Arg Ile 
    1520                 1525                 1530             


Glu Leu  Lys Gly Ile Asp Phe  Lys Glu Asp Gly Asn  Ile Leu Gly 
    1535                 1540                 1545             


His Lys  Leu Glu Tyr Asn Tyr  Asn Ser His Asn Val  Tyr Ile Met 
    1550                 1555                 1560             


Ala Asp  Lys Gln Lys Asn Gly  Ile Lys Val Asn Phe  Lys Ile Arg 
    1565                 1570                 1575             


His Asn  Ile Glu Asp Gly Ser  Val Gln Leu Ala Asp  His Tyr Gln 
    1580                 1585                 1590             


Gln Asn  Thr Pro Ile Gly Asp  Gly Pro Val Leu Leu  Pro Asp Asn 
    1595                 1600                 1605             


His Tyr  Leu Ser Thr Gln Ser  Lys Leu Ser Lys Asp  Pro Asn Glu 
    1610                 1615                 1620             


Lys Arg  Asp His Met Val Leu  Leu Glu Phe Val Thr  Ala Ala Gly 
    1625                 1630                 1635             


Ile Thr  Leu Gly Met Asp Glu  Leu Tyr Lys Asp Tyr  Lys Asp Asp 
    1640                 1645                 1650             


Asp Asp  Lys 
    1655     


<210> 19
<211> 1361
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala Ala 
            20                  25                  30          


His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp 
        35                  40                  45              


Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu 
    50                  55                  60                  


Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr 
65                  70                  75                  80  


Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro 
                85                  90                  95      


Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile 
            100                 105                 110         


Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln 
        115                 120                 125             


Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser 
    130                 135                 140                 


Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val Gly 
145                 150                 155                 160 


Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Ser Gly Gly Ser Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Gly Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
            180                 185                 190         


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
        195                 200                 205             


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
    210                 215                 220                 


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
225                 230                 235                 240 


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
                245                 250                 255     


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
            260                 265                 270         


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
        275                 280                 285             


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
    290                 295                 300                 


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
305                 310                 315                 320 


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Ser Gly Gly Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Ser Gly Met Gln Arg Gly Asp Glu Asp Pro Gln Ile 
            340                 345                 350         


Ala Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu 
        355                 360                 365             


Gln Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met 
    370                 375                 380                 


Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr 
385                 390                 395                 400 


Val Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln 
                405                 410                 415     


Arg Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu 
            420                 425                 430         


Arg Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys 
        435                 440                 445             


Glu Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly 
    450                 455                 460                 


Ala Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg 
465                 470                 475                 480 


Val Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Ser Ala Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Arg Val Val Arg Val Pro Thr Ala Thr 
            500                 505                 510         


Leu Val Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser 
        515                 520                 525             


Asp Tyr Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser 
    530                 535                 540                 


Leu Gly Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe 
545                 550                 555                 560 


Pro Ala Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu 
                565                 570                 575     


Arg Arg Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln 
            580                 585                 590         


Pro Ser Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala 
        595                 600                 605             


Thr Val Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala 
    610                 615                 620                 


Asp Ser Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser 
625                 630                 635                 640 


Leu Arg Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala 
                645                 650                 655     


Ser Pro Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly 
            660                 665                 670         


Pro Ala Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His 
        675                 680                 685             


Pro Gly Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu 
    690                 695                 700                 


Asp Thr Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu 
705                 710                 715                 720 


Ser Ala Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala 
                725                 730                 735     


Glu Gln Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala 
            740                 745                 750         


Thr Val Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn 
        755                 760                 765             


Val Ser Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr 
    770                 775                 780                 


Thr Asp Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser 
785                 790                 795                 800 


Arg Met Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu 
                805                 810                 815     


Asp Arg Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His 
            820                 825                 830         


Val Asp Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu 
        835                 840                 845             


Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His 
    850                 855                 860                 


Asn Arg Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly 
865                 870                 875                 880 


Val Gly Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala 
                885                 890                 895     


Ser Lys Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg 
            900                 905                 910         


Val Val Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser 
        915                 920                 925             


Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu 
    930                 935                 940                 


Leu Leu Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg 
945                 950                 955                 960 


Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His 
                965                 970                 975     


Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg 
            980                 985                 990         


Gly Asn Tyr Tyr Cys Val Val Ser  Ala Trp Thr Lys Gln  Arg Asn Asn 
        995                 1000                 1005             


Ser Trp  Val Lys Ser Lys Asp  Val Phe Ser Lys Pro  Val Asn Ile 
    1010                 1015                 1020             


Phe Trp  Ala Leu Glu Asp Ser  Val Leu Val Val Lys  Ala Arg Gln 
    1025                 1030                 1035             


Pro Lys  Pro Phe Phe Ala Ala  Gly Asn Thr Phe Glu  Met Thr Cys 
    1040                 1045                 1050             


Lys Val  Ser Ser Lys Asn Ile  Lys Ser Pro Arg Tyr  Ser Val Leu 
    1055                 1060                 1065             


Ile Met  Ala Glu Lys Pro Val  Gly Asp Leu Ser Ser  Pro Asn Glu 
    1070                 1075                 1080             


Thr Lys  Tyr Ile Ile Ser Leu  Asp Gln Asp Ser Val  Val Lys Leu 
    1085                 1090                 1095             


Glu Asn  Trp Thr Asp Ala Ser  Arg Val Asp Gly Val  Val Leu Glu 
    1100                 1105                 1110             


Lys Val  Gln Glu Asp Glu Phe  Arg Tyr Arg Met Tyr  Gln Thr Gln 
    1115                 1120                 1125             


Val Ser  Asp Ala Gly Leu Tyr  Arg Cys Met Val Thr  Ala Trp Ser 
    1130                 1135                 1140             


Pro Val  Arg Gly Ser Leu Trp  Arg Glu Ala Ala Thr  Ser Leu Ser 
    1145                 1150                 1155             


Asn Pro  Ile Glu Ile Asp Phe  Gln Thr Ser Gly Pro  Ile Phe Asn 
    1160                 1165                 1170             


Ala Ser  Val His Ser Asp Thr  Pro Ser Val Ile Arg  Gly Asp Leu 
    1175                 1180                 1185             


Ile Lys  Leu Phe Cys Ile Ile  Thr Val Glu Gly Ala  Ala Leu Asp 
    1190                 1195                 1200             


Pro Asp  Asp Met Ala Phe Asp  Val Ser Trp Phe Ala  Val His Ser 
    1205                 1210                 1215             


Phe Gly  Leu Asp Lys Ala Pro  Val Leu Leu Ser Ser  Leu Asp Arg 
    1220                 1225                 1230             


Lys Gly  Ile Val Thr Thr Ser  Arg Arg Asp Trp Lys  Ser Asp Leu 
    1235                 1240                 1245             


Ser Leu  Glu Arg Val Ser Val  Leu Glu Phe Leu Leu  Gln Val His 
    1250                 1255                 1260             


Gly Ser  Glu Asp Gln Asp Phe  Gly Asn Tyr Tyr Cys  Ser Val Thr 
    1265                 1270                 1275             


Pro Trp  Val Lys Ser Pro Thr  Gly Ser Trp Gln Lys  Glu Ala Glu 
    1280                 1285                 1290             


Ile His  Ser Lys Pro Val Phe  Ile Thr Val Lys Met  Asp Val Leu 
    1295                 1300                 1305             


Asn Ala  Phe Lys Tyr Pro Leu  Leu Ile Gly Val Gly  Leu Ser Thr 
    1310                 1315                 1320             


Val Ile  Gly Leu Leu Ser Cys  Leu Ile Gly Tyr Cys  Ser Ser His 
    1325                 1330                 1335             


Trp Cys  Cys Lys Lys Glu Val  Gln Glu Thr Arg Arg  Glu Arg Arg 
    1340                 1345                 1350             


Arg Leu  Met Ser Met Glu Met  Asp 
    1355                 1360     


<210> 20
<211> 1361
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala 
            20                  25                  30          


His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp 
        35                  40                  45              


Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu 
    50                  55                  60                  


Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr 
65                  70                  75                  80  


Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro 
                85                  90                  95      


Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile 
            100                 105                 110         


Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln 
        115                 120                 125             


Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser 
    130                 135                 140                 


Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly 
145                 150                 155                 160 


Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Ser Gly Gly Ser Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Gly Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
            180                 185                 190         


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
        195                 200                 205             


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
    210                 215                 220                 


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
225                 230                 235                 240 


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
                245                 250                 255     


Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg 
            260                 265                 270         


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
        275                 280                 285             


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
    290                 295                 300                 


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
305                 310                 315                 320 


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Ser Gly Gly Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Ser Gly Met Gln Lys Gly Asp Gln Asn Pro Gln Ile 
            340                 345                 350         


Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu 
        355                 360                 365             


Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr 
    370                 375                 380                 


Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr 
385                 390                 395                 400 


Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln 
                405                 410                 415     


Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu 
            420                 425                 430         


Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys 
        435                 440                 445             


Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly 
    450                 455                 460                 


Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly 
465                 470                 475                 480 


Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Ser Ala Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Arg Val Val Arg Val Pro Thr Ala Thr 
            500                 505                 510         


Leu Val Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser 
        515                 520                 525             


Asp Tyr Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser 
    530                 535                 540                 


Leu Gly Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe 
545                 550                 555                 560 


Pro Ala Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu 
                565                 570                 575     


Arg Arg Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln 
            580                 585                 590         


Pro Ser Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala 
        595                 600                 605             


Thr Val Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala 
    610                 615                 620                 


Asp Ser Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser 
625                 630                 635                 640 


Leu Arg Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala 
                645                 650                 655     


Ser Pro Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly 
            660                 665                 670         


Pro Ala Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His 
        675                 680                 685             


Pro Gly Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu 
    690                 695                 700                 


Asp Thr Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu 
705                 710                 715                 720 


Ser Ala Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala 
                725                 730                 735     


Glu Gln Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala 
            740                 745                 750         


Thr Val Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn 
        755                 760                 765             


Val Ser Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr 
    770                 775                 780                 


Thr Asp Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser 
785                 790                 795                 800 


Arg Met Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu 
                805                 810                 815     


Asp Arg Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His 
            820                 825                 830         


Val Asp Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu 
        835                 840                 845             


Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His 
    850                 855                 860                 


Asn Arg Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly 
865                 870                 875                 880 


Val Gly Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala 
                885                 890                 895     


Ser Lys Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg 
            900                 905                 910         


Val Val Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser 
        915                 920                 925             


Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu 
    930                 935                 940                 


Leu Leu Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg 
945                 950                 955                 960 


Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His 
                965                 970                 975     


Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg 
            980                 985                 990         


Gly Asn Tyr Tyr Cys Val Val Ser  Ala Trp Thr Lys Gln  Arg Asn Asn 
        995                 1000                 1005             


Ser Trp  Val Lys Ser Lys Asp  Val Phe Ser Lys Pro  Val Asn Ile 
    1010                 1015                 1020             


Phe Trp  Ala Leu Glu Asp Ser  Val Leu Val Val Lys  Ala Arg Gln 
    1025                 1030                 1035             


Pro Lys  Pro Phe Phe Ala Ala  Gly Asn Thr Phe Glu  Met Thr Cys 
    1040                 1045                 1050             


Lys Val  Ser Ser Lys Asn Ile  Lys Ser Pro Arg Tyr  Ser Val Leu 
    1055                 1060                 1065             


Ile Met  Ala Glu Lys Pro Val  Gly Asp Leu Ser Ser  Pro Asn Glu 
    1070                 1075                 1080             


Thr Lys  Tyr Ile Ile Ser Leu  Asp Gln Asp Ser Val  Val Lys Leu 
    1085                 1090                 1095             


Glu Asn  Trp Thr Asp Ala Ser  Arg Val Asp Gly Val  Val Leu Glu 
    1100                 1105                 1110             


Lys Val  Gln Glu Asp Glu Phe  Arg Tyr Arg Met Tyr  Gln Thr Gln 
    1115                 1120                 1125             


Val Ser  Asp Ala Gly Leu Tyr  Arg Cys Met Val Thr  Ala Trp Ser 
    1130                 1135                 1140             


Pro Val  Arg Gly Ser Leu Trp  Arg Glu Ala Ala Thr  Ser Leu Ser 
    1145                 1150                 1155             


Asn Pro  Ile Glu Ile Asp Phe  Gln Thr Ser Gly Pro  Ile Phe Asn 
    1160                 1165                 1170             


Ala Ser  Val His Ser Asp Thr  Pro Ser Val Ile Arg  Gly Asp Leu 
    1175                 1180                 1185             


Ile Lys  Leu Phe Cys Ile Ile  Thr Val Glu Gly Ala  Ala Leu Asp 
    1190                 1195                 1200             


Pro Asp  Asp Met Ala Phe Asp  Val Ser Trp Phe Ala  Val His Ser 
    1205                 1210                 1215             


Phe Gly  Leu Asp Lys Ala Pro  Val Leu Leu Ser Ser  Leu Asp Arg 
    1220                 1225                 1230             


Lys Gly  Ile Val Thr Thr Ser  Arg Arg Asp Trp Lys  Ser Asp Leu 
    1235                 1240                 1245             


Ser Leu  Glu Arg Val Ser Val  Leu Glu Phe Leu Leu  Gln Val His 
    1250                 1255                 1260             


Gly Ser  Glu Asp Gln Asp Phe  Gly Asn Tyr Tyr Cys  Ser Val Thr 
    1265                 1270                 1275             


Pro Trp  Val Lys Ser Pro Thr  Gly Ser Trp Gln Lys  Glu Ala Glu 
    1280                 1285                 1290             


Ile His  Ser Lys Pro Val Phe  Ile Thr Val Lys Met  Asp Val Leu 
    1295                 1300                 1305             


Asn Ala  Phe Lys Tyr Pro Leu  Leu Ile Gly Val Gly  Leu Ser Thr 
    1310                 1315                 1320             


Val Ile  Gly Leu Leu Ser Cys  Leu Ile Gly Tyr Cys  Ser Ser His 
    1325                 1330                 1335             


Trp Cys  Cys Lys Lys Glu Val  Gln Glu Thr Arg Arg  Glu Arg Arg 
    1340                 1345                 1350             


Arg Leu  Met Ser Met Glu Met  Asp 
    1355                 1360     


<210> 21
<211> 991
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Lys Ile Ile Cys Leu Ala Leu Val Ala Leu Leu Leu Thr Ala Gln 
1               5                   10                  15      


Pro Ala Met Ala Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Ser Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser 
                245                 250                 255     


Ala Gly Thr Thr Gly Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr 
        275                 280                 285             


Ala Gly Ala Ser Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Lys Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys 
            340                 345                 350         


Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    370                 375                 380                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe 
385                 390                 395                 400 


Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            420                 425                 430         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                485                 490                 495     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Ser Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val 
545                 550                 555                 560 


Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly 
                565                 570                 575     


Ala Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala 
            580                 585                 590         


Val His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu 
        595                 600                 605             


Asp Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp 
    610                 615                 620                 


Leu Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His 
625                 630                 635                 640 


Gly Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro 
                645                 650                 655     


Trp Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His 
            660                 665                 670         


Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe 
        675                 680                 685             


Lys Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu 
    690                 695                 700                 


Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys 
705                 710                 715                 720 


Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu 
                725                 730                 735     


Met Asp Thr Gly Gly Ser Gly Gly Ser Val Ser Lys Gly Glu Glu Leu 
            740                 745                 750         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        755                 760                 765             


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    770                 775                 780                 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
785                 790                 795                 800 


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
                805                 810                 815     


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            820                 825                 830         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        835                 840                 845             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    850                 855                 860                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
865                 870                 875                 880 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                885                 890                 895     


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
            900                 905                 910         


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        915                 920                 925             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    930                 935                 940                 


Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg 
945                 950                 955                 960 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
                965                 970                 975     


Gly Met Asp Glu Leu Tyr Lys Asp Tyr Lys Asp Asp Asp Asp Lys 
            980                 985                 990     


<210> 22
<211> 1055
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Ser Ala Gly Gly Gly Gly Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Arg Val Val Arg Val Pro Thr Ala Thr Leu Val 
        195                 200                 205             


Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr 
    210                 215                 220                 


Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly 
225                 230                 235                 240 


Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala 
                245                 250                 255     


Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg 
            260                 265                 270         


Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser 
        275                 280                 285             


Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val 
    290                 295                 300                 


Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser 
305                 310                 315                 320 


Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg 
                325                 330                 335     


Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro 
            340                 345                 350         


Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala 
        355                 360                 365             


Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly 
    370                 375                 380                 


Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr 
385                 390                 395                 400 


Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala 
                405                 410                 415     


Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln 
            420                 425                 430         


Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val 
        435                 440                 445             


Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser 
    450                 455                 460                 


Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp 
465                 470                 475                 480 


Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met 
                485                 490                 495     


Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg 
            500                 505                 510         


Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp 
        515                 520                 525             


Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser 
    530                 535                 540                 


Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg 
545                 550                 555                 560 


Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly 
                565                 570                 575     


Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys 
            580                 585                 590         


Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val 
        595                 600                 605             


Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr 
    610                 615                 620                 


Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu 
625                 630                 635                 640 


Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys 
                645                 650                 655     


Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp 
            660                 665                 670         


Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn 
        675                 680                 685             


Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp 
    690                 695                 700                 


Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala 
705                 710                 715                 720 


Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe 
                725                 730                 735     


Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys 
            740                 745                 750         


Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro 
        755                 760                 765             


Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu 
    770                 775                 780                 


Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg 
785                 790                 795                 800 


Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr 
                805                 810                 815     


Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met 
            820                 825                 830         


Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala 
        835                 840                 845             


Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro 
    850                 855                 860                 


Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly 
865                 870                 875                 880 


Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu 
                885                 890                 895     


Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser 
            900                 905                 910         


Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys 
        915                 920                 925             


Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu 
    930                 935                 940                 


Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu 
945                 950                 955                 960 


Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys 
                965                 970                 975     


Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro 
            980                 985                 990         


Val Phe Ile Thr Val Lys Met Asp  Val Leu Asn Ala Phe  Lys Tyr Pro 
        995                 1000                 1005             


Leu Leu  Ile Gly Val Gly Leu  Ser Thr Val Ile Gly  Leu Leu Ser 
    1010                 1015                 1020             


Cys Leu  Ile Gly Tyr Cys Ser  Ser His Trp Cys Cys  Lys Lys Glu 
    1025                 1030                 1035             


Val Gln  Glu Thr Arg Arg Glu  Arg Arg Arg Leu Met  Ser Met Glu 
    1040                 1045                 1050             


Met Asp  
    1055 


<210> 23
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Glu His Ser Ala Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
1               5                   10                  15      


Lys Gly Gly Gly Gly Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln 
            20                  25                  30          


Thr Ser Gly Pro Ile Phe 
        35              


<210> 24
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Glu His Ser Ala Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
1               5                   10                  15      


Lys Gly Gly Gly Gly Ser Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro 
            20                  25                  30          


Ile Phe 
        


<210> 25
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Glu His Ser Ala Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
1               5                   10                  15      


Lys Gly Gly Gly Gly Ser Phe Gln Thr Ser Gly Pro Ile Phe 
            20                  25                  30  


<210> 26
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Glu His Ser Ala Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
1               5                   10                  15      


Lys Gly Gly Gly Gly Ser Gly Pro Ile Phe 
            20                  25      


