                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS 
      TO INFLAME THE TUMOR MICROENVIRONMENT

<130> 030258-090990WOPT

<140>
<141>

<150> 62/611,186
<151> 2017-12-28

<160> 49    

<170> PatentIn version 3.5

<210> 1
<211> 3465
<212> DNA
<213> Homo sapiens

<400> 1
atgccaggag gagggccaga gatggatgac tacatggaga cgctgaagga tgaagaggac       60

gccttgtggg agaatgtgga gtgtaaccgg cacatgctca gccgctatat caaccctgcc      120

aagctcacgc cctacctgcg tcagtgtaag gtcattgatg agcaggatga agatgaagtg      180

cttaatgccc ctatgctgcc atccaagatc aaccgagcag gccggctgtt ggacattcta      240

cataccaagg ggcaaagggg ctatgtggtc ttcttggaga gcctagaatt ttattaccca      300

gaactgtaca aactggtgac tgggaaagag cccactcgga gattctccac cattgtggtg      360

gaggaaggcc acgagggcct cacgcacttc ctgatgaacg aggtcatcaa gctgcagcag      420

cagatgaagg ccaaggacct gcaacgctgc gagctgctgg ccaggttgcg gcagctggag      480

gatgagaaga agcagatgac gctgacgcgc gtggagctgc taaccttcca ggagcggtac      540

tacaagatga aggaagagcg ggacagctac aatgacgagc tggtcaaggt gaaggacgac      600

aactacaact tagccatgcg ctacgcacag ctcagtgagg agaagaacat ggcggtcatg      660

aggagccgag acctccaact cgagatcgat cagctaaagc accggttgaa taagatggag      720

gaggaatgta agctggagag aaatcagtct ctaaaactga agaatgacat tgaaaatcgg      780

cccaagaagg agcaggttct ggaactggag cgggagaatg aaatgctgaa gaccaaaaac      840

caggagctgc agtccatcat ccaggccggg aagcgcagcc tgccagactc agacaaggcc      900

atcctggaca tcttggaaca cgaccgcaag gaggccctgg aggacaggca ggagctggtc      960

aacaggatct acaacctgca ggaggaggcc cgccaggcag aggagctgcg agacaagtac     1020

ctggaggaga aggaggacct ggagctcaag tgctcgaccc tgggaaagga ctgtgaaatg     1080

tacaagcacc gcatgaacac ggtcatgctg cagctggagg aggtggagcg ggagcgggac     1140

caggccttcc actcccgaga tgaagctcag acacagtact cgcagtgctt aatcgaaaag     1200

gacaagtaca ggaagcagat ccgcgagctg gaggagaaga acgacgagat gaggatcgag     1260

atggtgcggc gggaggcctg catcgtcaac ctggagagca agctgcggcg cctctccaag     1320

gacagcaaca acctggacca gagtctgccc aggaacctgc cagtaaccat catctctcag     1380

gactttgggg atgccagccc caggaccaat ggtcaagaag ctgacgattc ttccacctcg     1440

gaggagtcac ctgaagacag caagtacttc ctgccctacc atccgcccca gcgcaggatg     1500

aacctgaagg gcatccagct gcagagagcc aaatccccca tcagcctgaa gcgaacatca     1560

gattttcaag ccaaggggca cgaggaagaa ggcacggacg ccagccctag ctcctgcgga     1620

tctctgccca tcaccaactc cttcaccaag atgcagcccc cccggagccg cagcagcatc     1680

atgtcaatca ccgccgagcc cccgggaaac gactccatcg tcagacgcta caaggaggac     1740

gcgccccatc gcagcacagt cgaagaagac aatgacagcg gcgggtttga cgccttagat     1800

ctggatgatg acagtcacga acgctactcc ttcggaccct cctccatcca ctcctcctcc     1860

tcctcccacc aatccgaggg cctggatgcc tacgacctgg agcaggtcaa cctcatgttc     1920

aggaagttct ctctggaaag acccttccgg ccttcggtca cctctgtggg gcacgtgcgg     1980

ggcccagggc cctcggtgca gcacacgacg ctgaatggcg acagcctcac ctcccagctc     2040

accctgctgg ggggcaacgc gcgagggagc ttcgtgcact cggtcaagcc tggctctctg     2100

gccgagaaag ccggcctccg tgagggccac cagctgctgc tgctagaagg ctgcatccga     2160

ggcgagaggc agagtgtccc gttggacaca tgcaccaaag aggaagccca ctggaccatc     2220

cagaggtgca gcggccccgt cacgctgcac tacaaggtca accacgaagg gtaccggaag     2280

ctggtgaagg acatggagga cggcctgatc acatcggggg actcgttcta catccggctg     2340

aacctgaaca tctccagcca gctggacgcc tgcaccatgt ccctgaagtg tgacgatgtt     2400

gtgcacgtcc gtgacaccat gtaccaggac aggcacgagt ggctgtgcgc gcgggtcgac     2460

cctttcacag accatgacct ggatatgggc accataccca gctacagccg agcccagcag     2520

ctcctcctgg tgaaactgca gcgcctgatg caccgaggca gccgggagga ggtagacggc     2580

acccaccaca ccctgcgggc actccggaac accctgcagc cagaagaagc gctttcaaca     2640

agcgaccccc gggtcagccc ccgtctctcg cgagcaagct tcctttttgg ccagctcctt     2700

cagttcgtca gcaggtccga gaacaagtat aagcggatga acagcaacga gcgggtccgc     2760

atcatctcgg ggagtccgct agggagcctg gcccggtcct cgctggacgc caccaagctc     2820

ttgactgaga agcaggaaga gctggaccct gagagcgagc tgggcaagaa cctcagcctc     2880

atcccctaca gcctggtacg cgccttctac tgcgagcgcc gccggcccgt gctcttcaca     2940

cccaccgtgc tggccaagac gctggtgcag aggctgctca actcgggagg tgccatggag     3000

ttcaccatct gcaagtcaga tatcgtcaca agagatgagt tcctcagaag gcagaagacg     3060

gagaccatca tctactcccg agagaagaac cccaacgcgt tcgaatgcat cgcccctgcc     3120

aacattgaag ctgtggccgc caagaacaag cactgcctgc tggaggctgg gatcggctgc     3180

acaagagact tgatcaagtc caacatctac cccatcgtgc tcttcatccg ggtgtgtgag     3240

aagaacatca agaggttcag aaagctgctg ccccgacctg agacggagga ggagttcctg     3300

cgcgtgtgcc ggctgaagga gaaggagctg gaggccctgc cgtgcctgta cgccacggtg     3360

gaacctgaca tgtggggcag cgtagaggag ctgctccgcg ttgtcaagga caagatcggc     3420

gaggagcagc gcaagaccat ctgggtggac gaggaccagc tgtga                     3465


<210> 2
<211> 669
<212> DNA
<213> Homo sapiens

<400> 2
atggagccca ccgcaccgtc cctcaccgag gaggacctca ctgaagtgaa gaaggacgcc       60

ttagaaaatt tacgtgtata cctgtgtgag aaaatcatag ctgagagaca ttttgatcat      120

ctacgtgcaa aaaaaatact cagtagagaa gacactgaag aaatttcttg tcgaacatca      180

agtagaaaaa gggctggaaa attgttagac tacttacagg aaaacccaaa aggtctggac      240

acccttgttg aatctattcg gcgagaaaaa acacagaact tcctgataca gaagattaca      300

gatgaagtgc tgaaacttag aaatataaaa ctagaacatc tgaaagatgg agccacgaac      360

aacctctcca gatcaaattc agatgagagt aatttctctg aaaaactgag ggcatccact      420

gtcatgtacc atccagaagg agaatccagc acgacgccct ttttttctac taattcttct      480

ctgaatttgc ctgttctaga agtaggcaga actgaaaata ccatcttctc ttcaactaca      540

cttcccagac ctggggaccc aggggctcct cctttgccac cagatctaca gttagaagaa      600

gaaggaactt gtgcaaactc tagtgagatg tttcttccct taagatcacg tactgtttca      660

cgacaatga                                                              669


<210> 3
<211> 2475
<212> DNA
<213> Homo sapiens

<400> 3
atgtcgctgt tgggggaccc gctacaggcc ctgccgccct cggccgcccc cacggggccg       60

ctgctcgccc ctccggccgg cgcgaccctc aaccgcctgc gggagccgct gctgcggagg      120

ctcagcgagc tcctggatca ggcgcccgag ggccggggct ggaggagact ggcggagctg      180

gcggggagtc gcgggcgcct ccgcctcagt tgcctagacc tggagcagtg ttctcttaag      240

gtactggagc ctgaaggaag ccccagcctg tgtctgctga agttaatggg tgaaaaaggt      300

tgcacagtca cagaattgag tgatttcctg caggctatgg aacacactga agttcttcag      360

cttctcagcc ccccaggaat aaagattact gtaaacccag agtcaaaggc agtcttggct      420

ggacagtttg tgaaactgtg ttgccgggca actggacatc cttttgttca atatcagtgg      480

ttcaaaatga ataaagagat tccaaatgga aatacatcag agcttatttt taatgcagtg      540

catgtaaaag atgcaggctt ttatgtctgt cgagttaata acaatttcac ctttgaattc      600

agccagtggt cacagctgga tgtttgcgac atcccagaga gcttccagag aagtgttgat      660

ggcgtctctg aatccaagtt gcaaatctgt gttgaaccaa cttcccaaaa gctgatgcca      720

ggcagcacat tggttttaca gtgtgttgct gttggaagcc ctattcctca ctaccagtgg      780

ttcaaaaatg aattaccatt aacacatgag accaaaaagc tatacatggt gccttatgtg      840

gatttggaac accaaggaac ctactggtgt catgtatata atgatcgaga cagtcaagat      900

agcaagaagg tagaaatcat cataggaaga acagatgagg cagtggagtg cactgaagat      960

gaattaaata atcttggtca tcctgataat aaagagcaaa caactgacca gcctttggcg     1020

aaggacaagg ttgccctttt gataggaaat atgaattacc gggagcaccc caagctcaaa     1080

gctcctttgg tggatgtgta cgaattgact aacttactga gacagctgga cttcaaagtg     1140

gtttcactgt tggatcttac tgaatatgag atgcgtaatg ctgtggatga gtttttactc     1200

cttttagaca agggagtata tgggttatta tattatgcag gacatggtta tgaaaatttt     1260

gggaacagct tcatggtccc cgttgatgct ccaaatccat ataggtctga aaattgtctg     1320

tgtgtacaaa atatactgaa attgatgcaa gaaaaagaaa ctggacttaa tgtgttctta     1380

ttggatatgt gtaggaaaag aaatgactac gatgatacca ttccaatctt ggatgcacta     1440

aaagtcaccg ccaatattgt gtttggatat gccacgtgtc aaggagcaga agcttttgaa     1500

atccagcatt ctggattggc aaatggaatc tttatgaaat ttttaaaaga cagattatta     1560

gaagataaga aaatcactgt gttactggat gaagttgcag aagatatggg taagtgtcac     1620

cttaccaaag gcaaacaggc tctagagatt cgaagtagtt tatctgagaa gagagcactt     1680

actgatccaa tacagggaac agaatattct gctgaatctc ttgtgcggaa tctacagtgg     1740

gccaaggctc atgaacttcc agaaagtatg tgtcttaagt ttgactgtgg tgttcagatt     1800

caattaggat ttgcagctga gttttccaat gtcatgatca tctatacaag tatagtttac     1860

aaaccaccgg agataataat gtgtgatgcc tacgttactg attttccact tgatctagat     1920

attgatccaa aagatgcaaa taaaggcaca cctgaagaaa ctggcagcta cttggtatca     1980

aaggatcttc ccaagcattg cctctatacc agactcagtt cactgcaaaa attaaaggaa     2040

catctagtct tcacagtatg tttatcatat cagtactcag gattggaaga tactgtagag     2100

gacaagcagg aagtgaatgt tgggaaacct ctcattgcta aattagacat gcatcgaggt     2160

ttgggaagga agacttgctt tcaaacttgt cttatgtcta atggtcctta ccagagttct     2220

gcagccacct caggaggagc agggcattat cactcattgc aagacccatt ccatggtgtt     2280

taccattcac atcctggtaa tccaagtaat gttacaccag cagatagctg tcattgcagc     2340

cggactccag atgcatttat ttcaagtttc gctcaccatg cttcatgtca ttttagtaga     2400

agtaatgtgc cagtagagac aactgatgaa ataccattta gtttctctga caggctcaga     2460

atttctgaaa aatga                                                      2475


<210> 4
<211> 1154
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Gly Gly Gly Pro Glu Met Asp Asp Tyr Met Glu Thr Leu Lys 
1               5                   10                  15      


Asp Glu Glu Asp Ala Leu Trp Glu Asn Val Glu Cys Asn Arg His Met 
            20                  25                  30          


Leu Ser Arg Tyr Ile Asn Pro Ala Lys Leu Thr Pro Tyr Leu Arg Gln 
        35                  40                  45              


Cys Lys Val Ile Asp Glu Gln Asp Glu Asp Glu Val Leu Asn Ala Pro 
    50                  55                  60                  


Met Leu Pro Ser Lys Ile Asn Arg Ala Gly Arg Leu Leu Asp Ile Leu 
65                  70                  75                  80  


His Thr Lys Gly Gln Arg Gly Tyr Val Val Phe Leu Glu Ser Leu Glu 
                85                  90                  95      


Phe Tyr Tyr Pro Glu Leu Tyr Lys Leu Val Thr Gly Lys Glu Pro Thr 
            100                 105                 110         


Arg Arg Phe Ser Thr Ile Val Val Glu Glu Gly His Glu Gly Leu Thr 
        115                 120                 125             


His Phe Leu Met Asn Glu Val Ile Lys Leu Gln Gln Gln Met Lys Ala 
    130                 135                 140                 


Lys Asp Leu Gln Arg Cys Glu Leu Leu Ala Arg Leu Arg Gln Leu Glu 
145                 150                 155                 160 


Asp Glu Lys Lys Gln Met Thr Leu Thr Arg Val Glu Leu Leu Thr Phe 
                165                 170                 175     


Gln Glu Arg Tyr Tyr Lys Met Lys Glu Glu Arg Asp Ser Tyr Asn Asp 
            180                 185                 190         


Glu Leu Val Lys Val Lys Asp Asp Asn Tyr Asn Leu Ala Met Arg Tyr 
        195                 200                 205             


Ala Gln Leu Ser Glu Glu Lys Asn Met Ala Val Met Arg Ser Arg Asp 
    210                 215                 220                 


Leu Gln Leu Glu Ile Asp Gln Leu Lys His Arg Leu Asn Lys Met Glu 
225                 230                 235                 240 


Glu Glu Cys Lys Leu Glu Arg Asn Gln Ser Leu Lys Leu Lys Asn Asp 
                245                 250                 255     


Ile Glu Asn Arg Pro Lys Lys Glu Gln Val Leu Glu Leu Glu Arg Glu 
            260                 265                 270         


Asn Glu Met Leu Lys Thr Lys Asn Gln Glu Leu Gln Ser Ile Ile Gln 
        275                 280                 285             


Ala Gly Lys Arg Ser Leu Pro Asp Ser Asp Lys Ala Ile Leu Asp Ile 
    290                 295                 300                 


Leu Glu His Asp Arg Lys Glu Ala Leu Glu Asp Arg Gln Glu Leu Val 
305                 310                 315                 320 


Asn Arg Ile Tyr Asn Leu Gln Glu Glu Ala Arg Gln Ala Glu Glu Leu 
                325                 330                 335     


Arg Asp Lys Tyr Leu Glu Glu Lys Glu Asp Leu Glu Leu Lys Cys Ser 
            340                 345                 350         


Thr Leu Gly Lys Asp Cys Glu Met Tyr Lys His Arg Met Asn Thr Val 
        355                 360                 365             


Met Leu Gln Leu Glu Glu Val Glu Arg Glu Arg Asp Gln Ala Phe His 
    370                 375                 380                 


Ser Arg Asp Glu Ala Gln Thr Gln Tyr Ser Gln Cys Leu Ile Glu Lys 
385                 390                 395                 400 


Asp Lys Tyr Arg Lys Gln Ile Arg Glu Leu Glu Glu Lys Asn Asp Glu 
                405                 410                 415     


Met Arg Ile Glu Met Val Arg Arg Glu Ala Cys Ile Val Asn Leu Glu 
            420                 425                 430         


Ser Lys Leu Arg Arg Leu Ser Lys Asp Ser Asn Asn Leu Asp Gln Ser 
        435                 440                 445             


Leu Pro Arg Asn Leu Pro Val Thr Ile Ile Ser Gln Asp Phe Gly Asp 
    450                 455                 460                 


Ala Ser Pro Arg Thr Asn Gly Gln Glu Ala Asp Asp Ser Ser Thr Ser 
465                 470                 475                 480 


Glu Glu Ser Pro Glu Asp Ser Lys Tyr Phe Leu Pro Tyr His Pro Pro 
                485                 490                 495     


Gln Arg Arg Met Asn Leu Lys Gly Ile Gln Leu Gln Arg Ala Lys Ser 
            500                 505                 510         


Pro Ile Ser Leu Lys Arg Thr Ser Asp Phe Gln Ala Lys Gly His Glu 
        515                 520                 525             


Glu Glu Gly Thr Asp Ala Ser Pro Ser Ser Cys Gly Ser Leu Pro Ile 
    530                 535                 540                 


Thr Asn Ser Phe Thr Lys Met Gln Pro Pro Arg Ser Arg Ser Ser Ile 
545                 550                 555                 560 


Met Ser Ile Thr Ala Glu Pro Pro Gly Asn Asp Ser Ile Val Arg Arg 
                565                 570                 575     


Tyr Lys Glu Asp Ala Pro His Arg Ser Thr Val Glu Glu Asp Asn Asp 
            580                 585                 590         


Ser Gly Gly Phe Asp Ala Leu Asp Leu Asp Asp Asp Ser His Glu Arg 
        595                 600                 605             


Tyr Ser Phe Gly Pro Ser Ser Ile His Ser Ser Ser Ser Ser His Gln 
    610                 615                 620                 


Ser Glu Gly Leu Asp Ala Tyr Asp Leu Glu Gln Val Asn Leu Met Phe 
625                 630                 635                 640 


Arg Lys Phe Ser Leu Glu Arg Pro Phe Arg Pro Ser Val Thr Ser Val 
                645                 650                 655     


Gly His Val Arg Gly Pro Gly Pro Ser Val Gln His Thr Thr Leu Asn 
            660                 665                 670         


Gly Asp Ser Leu Thr Ser Gln Leu Thr Leu Leu Gly Gly Asn Ala Arg 
        675                 680                 685             


Gly Ser Phe Val His Ser Val Lys Pro Gly Ser Leu Ala Glu Lys Ala 
    690                 695                 700                 


Gly Leu Arg Glu Gly His Gln Leu Leu Leu Leu Glu Gly Cys Ile Arg 
705                 710                 715                 720 


Gly Glu Arg Gln Ser Val Pro Leu Asp Thr Cys Thr Lys Glu Glu Ala 
                725                 730                 735     


His Trp Thr Ile Gln Arg Cys Ser Gly Pro Val Thr Leu His Tyr Lys 
            740                 745                 750         


Val Asn His Glu Gly Tyr Arg Lys Leu Val Lys Asp Met Glu Asp Gly 
        755                 760                 765             


Leu Ile Thr Ser Gly Asp Ser Phe Tyr Ile Arg Leu Asn Leu Asn Ile 
    770                 775                 780                 


Ser Ser Gln Leu Asp Ala Cys Thr Met Ser Leu Lys Cys Asp Asp Val 
785                 790                 795                 800 


Val His Val Arg Asp Thr Met Tyr Gln Asp Arg His Glu Trp Leu Cys 
                805                 810                 815     


Ala Arg Val Asp Pro Phe Thr Asp His Asp Leu Asp Met Gly Thr Ile 
            820                 825                 830         


Pro Ser Tyr Ser Arg Ala Gln Gln Leu Leu Leu Val Lys Leu Gln Arg 
        835                 840                 845             


Leu Met His Arg Gly Ser Arg Glu Glu Val Asp Gly Thr His His Thr 
    850                 855                 860                 


Leu Arg Ala Leu Arg Asn Thr Leu Gln Pro Glu Glu Ala Leu Ser Thr 
865                 870                 875                 880 


Ser Asp Pro Arg Val Ser Pro Arg Leu Ser Arg Ala Ser Phe Leu Phe 
                885                 890                 895     


Gly Gln Leu Leu Gln Phe Val Ser Arg Ser Glu Asn Lys Tyr Lys Arg 
            900                 905                 910         


Met Asn Ser Asn Glu Arg Val Arg Ile Ile Ser Gly Ser Pro Leu Gly 
        915                 920                 925             


Ser Leu Ala Arg Ser Ser Leu Asp Ala Thr Lys Leu Leu Thr Glu Lys 
    930                 935                 940                 


Gln Glu Glu Leu Asp Pro Glu Ser Glu Leu Gly Lys Asn Leu Ser Leu 
945                 950                 955                 960 


Ile Pro Tyr Ser Leu Val Arg Ala Phe Tyr Cys Glu Arg Arg Arg Pro 
                965                 970                 975     


Val Leu Phe Thr Pro Thr Val Leu Ala Lys Thr Leu Val Gln Arg Leu 
            980                 985                 990         


Leu Asn Ser Gly Gly Ala Met Glu  Phe Thr Ile Cys Lys  Ser Asp Ile 
        995                 1000                 1005             


Val Thr  Arg Asp Glu Phe Leu  Arg Arg Gln Lys Thr  Glu Thr Ile 
    1010                 1015                 1020             


Ile Tyr  Ser Arg Glu Lys Asn  Pro Asn Ala Phe Glu  Cys Ile Ala 
    1025                 1030                 1035             


Pro Ala  Asn Ile Glu Ala Val  Ala Ala Lys Asn Lys  His Cys Leu 
    1040                 1045                 1050             


Leu Glu  Ala Gly Ile Gly Cys  Thr Arg Asp Leu Ile  Lys Ser Asn 
    1055                 1060                 1065             


Ile Tyr  Pro Ile Val Leu Phe  Ile Arg Val Cys Glu  Lys Asn Ile 
    1070                 1075                 1080             


Lys Arg  Phe Arg Lys Leu Leu  Pro Arg Pro Glu Thr  Glu Glu Glu 
    1085                 1090                 1095             


Phe Leu  Arg Val Cys Arg Leu  Lys Glu Lys Glu Leu  Glu Ala Leu 
    1100                 1105                 1110             


Pro Cys  Leu Tyr Ala Thr Val  Glu Pro Asp Met Trp  Gly Ser Val 
    1115                 1120                 1125             


Glu Glu  Leu Leu Arg Val Val  Lys Asp Lys Ile Gly  Glu Glu Gln 
    1130                 1135                 1140             


Arg Lys  Thr Ile Trp Val Asp  Glu Asp Gln Leu 
    1145                 1150                 


<210> 5
<211> 222
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Pro Thr Ala Pro Ser Leu Thr Glu Glu Asp Leu Thr Glu Val 
1               5                   10                  15      


Lys Lys Asp Ala Leu Glu Asn Leu Arg Val Tyr Leu Cys Glu Lys Ile 
            20                  25                  30          


Ile Ala Glu Arg His Phe Asp His Leu Arg Ala Lys Lys Ile Leu Ser 
        35                  40                  45              


Arg Glu Asp Thr Glu Glu Ile Ser Cys Arg Thr Ser Ser Arg Lys Arg 
    50                  55                  60                  


Ala Gly Lys Leu Leu Asp Tyr Leu Gln Glu Asn Pro Lys Gly Leu Asp 
65                  70                  75                  80  


Thr Leu Val Glu Ser Ile Arg Arg Glu Lys Thr Gln Asn Phe Leu Ile 
                85                  90                  95      


Gln Lys Ile Thr Asp Glu Val Leu Lys Leu Arg Asn Ile Lys Leu Glu 
            100                 105                 110         


His Leu Lys Asp Gly Ala Thr Asn Asn Leu Ser Arg Ser Asn Ser Asp 
        115                 120                 125             


Glu Ser Asn Phe Ser Glu Lys Leu Arg Ala Ser Thr Val Met Tyr His 
    130                 135                 140                 


Pro Glu Gly Glu Ser Ser Thr Thr Pro Phe Phe Ser Thr Asn Ser Ser 
145                 150                 155                 160 


Leu Asn Leu Pro Val Leu Glu Val Gly Arg Thr Glu Asn Thr Ile Phe 
                165                 170                 175     


Ser Ser Thr Thr Leu Pro Arg Pro Gly Asp Pro Gly Ala Pro Pro Leu 
            180                 185                 190         


Pro Pro Asp Leu Gln Leu Glu Glu Glu Gly Thr Cys Ala Asn Ser Ser 
        195                 200                 205             


Glu Met Phe Leu Pro Leu Arg Ser Arg Thr Val Ser Arg Gln 
    210                 215                 220         


<210> 6
<211> 824
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser Leu Leu Gly Asp Pro Leu Gln Ala Leu Pro Pro Ser Ala Ala 
1               5                   10                  15      


Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg 
            20                  25                  30          


Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gln Ala 
        35                  40                  45              


Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg 
    50                  55                  60                  


Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gln Cys Ser Leu Lys 
65                  70                  75                  80  


Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met 
                85                  90                  95      


Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln Ala 
            100                 105                 110         


Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile Lys 
        115                 120                 125             


Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe Val 
    130                 135                 140                 


Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln Trp 
145                 150                 155                 160 


Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu Ile 
                165                 170                 175     


Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val 
            180                 185                 190         


Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp Val 
        195                 200                 205             


Cys Asp Ile Pro Glu Ser Phe Gln Arg Ser Val Asp Gly Val Ser Glu 
    210                 215                 220                 


Ser Lys Leu Gln Ile Cys Val Glu Pro Thr Ser Gln Lys Leu Met Pro 
225                 230                 235                 240 


Gly Ser Thr Leu Val Leu Gln Cys Val Ala Val Gly Ser Pro Ile Pro 
                245                 250                 255     


His Tyr Gln Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys 
            260                 265                 270         


Lys Leu Tyr Met Val Pro Tyr Val Asp Leu Glu His Gln Gly Thr Tyr 
        275                 280                 285             


Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gln Asp Ser Lys Lys Val 
    290                 295                 300                 


Glu Ile Ile Ile Gly Arg Thr Asp Glu Ala Val Glu Cys Thr Glu Asp 
305                 310                 315                 320 


Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys Glu Gln Thr Thr Asp 
                325                 330                 335     


Gln Pro Leu Ala Lys Asp Lys Val Ala Leu Leu Ile Gly Asn Met Asn 
            340                 345                 350         


Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu Val Asp Val Tyr Glu 
        355                 360                 365             


Leu Thr Asn Leu Leu Arg Gln Leu Asp Phe Lys Val Val Ser Leu Leu 
    370                 375                 380                 


Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val Asp Glu Phe Leu Leu 
385                 390                 395                 400 


Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr Tyr Ala Gly His Gly 
                405                 410                 415     


Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro Val Asp Ala Pro Asn 
            420                 425                 430         


Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gln Asn Ile Leu Lys Leu 
        435                 440                 445             


Met Gln Glu Lys Glu Thr Gly Leu Asn Val Phe Leu Leu Asp Met Cys 
    450                 455                 460                 


Arg Lys Arg Asn Asp Tyr Asp Asp Thr Ile Pro Ile Leu Asp Ala Leu 
465                 470                 475                 480 


Lys Val Thr Ala Asn Ile Val Phe Gly Tyr Ala Thr Cys Gln Gly Ala 
                485                 490                 495     


Glu Ala Phe Glu Ile Gln His Ser Gly Leu Ala Asn Gly Ile Phe Met 
            500                 505                 510         


Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys Lys Ile Thr Val Leu 
        515                 520                 525             


Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys His Leu Thr Lys Gly 
    530                 535                 540                 


Lys Gln Ala Leu Glu Ile Arg Ser Ser Leu Ser Glu Lys Arg Ala Leu 
545                 550                 555                 560 


Thr Asp Pro Ile Gln Gly Thr Glu Tyr Ser Ala Glu Ser Leu Val Arg 
                565                 570                 575     


Asn Leu Gln Trp Ala Lys Ala His Glu Leu Pro Glu Ser Met Cys Leu 
            580                 585                 590         


Lys Phe Asp Cys Gly Val Gln Ile Gln Leu Gly Phe Ala Ala Glu Phe 
        595                 600                 605             


Ser Asn Val Met Ile Ile Tyr Thr Ser Ile Val Tyr Lys Pro Pro Glu 
    610                 615                 620                 


Ile Ile Met Cys Asp Ala Tyr Val Thr Asp Phe Pro Leu Asp Leu Asp 
625                 630                 635                 640 


Ile Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro Glu Glu Thr Gly Ser 
                645                 650                 655     


Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys Leu Tyr Thr Arg Leu 
            660                 665                 670         


Ser Ser Leu Gln Lys Leu Lys Glu His Leu Val Phe Thr Val Cys Leu 
        675                 680                 685             


Ser Tyr Gln Tyr Ser Gly Leu Glu Asp Thr Val Glu Asp Lys Gln Glu 
    690                 695                 700                 


Val Asn Val Gly Lys Pro Leu Ile Ala Lys Leu Asp Met His Arg Gly 
705                 710                 715                 720 


Leu Gly Arg Lys Thr Cys Phe Gln Thr Cys Leu Met Ser Asn Gly Pro 
                725                 730                 735     


Tyr Gln Ser Ser Ala Ala Thr Ser Gly Gly Ala Gly His Tyr His Ser 
            740                 745                 750         


Leu Gln Asp Pro Phe His Gly Val Tyr His Ser His Pro Gly Asn Pro 
        755                 760                 765             


Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys Ser Arg Thr Pro Asp 
    770                 775                 780                 


Ala Phe Ile Ser Ser Phe Ala His His Ala Ser Cys His Phe Ser Arg 
785                 790                 795                 800 


Ser Asn Val Pro Val Glu Thr Thr Asp Glu Ile Pro Phe Ser Phe Ser 
                805                 810                 815     


Asp Arg Leu Arg Ile Ser Glu Lys 
            820                 


<210> 7
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Val Arg Pro Arg 
1               


<210> 8
<211> 8
<212> PRT
<213> Gallus gallus

<400> 8
Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210> 9
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Leu Ser Ser Arg 
1               


<210> 10
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Leu Ser Ser Arg 
1               


<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Ala Ser Arg 
1               


<210> 12
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Ala Ser Arg 
1               


<210> 13
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (57)..(57)
<223> a, c, t, g, unknown or other

<400> 13
aagcagtggt atcaacgcag agtacttttt tttttttttt tttttttttt tttttvn          57


<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 14
aagcagtggt atcaacgcag agtacatggg                                        30


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
aagcagtggt atcaacgcag agt                                               23


<210> 16
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (30)..(37)
<223> This region may encompass one of the following sequences:
      "AAGTAGAG" or "ACACGATC" or "TGTTCCGA"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 16
aatgatacgg cgaccaccga gatctacacn nnnnnnntcg tcggcagcgt c                51


<210> 17
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (25)..(32)
<223> This region may encompass one of the following sequences:
     "AGCAATTC" or "AACTTGAC" or "TGTCGGAT" or "TCGCCTTG" or
     "AAGACACT" or "TCTCGGTC"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 17
caagcagaag acggcatacg agatnnnnnn nngtgactgg agttcagacg tgtgctcttc       60

cgatctggg                                                               69


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
acatgctgag ccgttacatc a                                                 21


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ccacatagcc cctttgtccc                                                   20


<210> 20
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
cggcacagtc attgaaagcc ta                                                22


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
gttgctgatg gcctgattgt c                                                 21


<210> 22
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gcttcctaga ttaccccttc tgc                                               23


<210> 23
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
cgggcatggt tctggatca                                                    19


<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
ccacattcaa agccctctcc ta                                                22


<210> 25
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
gttttcccac acttcatctt gc                                                22


<210> 26
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ttggccagcg ccatctt                                                      17


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
tgcctcctcc agagagaagt g                                                 21


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
aaggttcaga acggaagtg                                                    19


<210> 29
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
gggtctccac agtggtact                                                    19


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
caaatcccac acaaccactg                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
tgctcacttg gtcacaggac                                                   20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
catgtagggt cgagagtggg                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
cctcctgcta ctgctgacct                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
tgctgcataa tcagctacgg                                                   20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
gctggtcaca ttgagaagca                                                   20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
acaagctgct acaaccaggg                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
acttctggct ggagacctca                                                   20


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
gtggccgcag tgggacaaga g                                                 21


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
agggcactgg tggcatcatc                                                   20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
tggtgaaatt gcaagagctg                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
cagacttccg ttggtggatt                                                   20


<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
cagaggaaag agagaaagtc c                                                 21


<210> 43
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
cacacggtga cagtgctgg                                                    19


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
catcctgctg ggtctgagtg                                                   20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
attctcactg gcccgtcatc                                                   20


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
caagagagtg ctgttccagg t                                                 21


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
gagcacgctg agtacctcat t                                                 21


<210> 48
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
tggtgaaggt cggtgaac                                                     18


<210> 49
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
ccatgtagtt gaggtcaatg aagg                                              24

