                         SEQUENCE LISTING

<110>  Yale University
       Desir, Gary
       Nelson, Bryce
 
<120>  Anti-Renalase Antibodies for the Treatment and Prevention of 
       Diseases and Disorders

<130>  047162-5248-00-WO.608350

<150>  US 62/611,609
<151>  2017-12-29

<160>  225   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, antigen seq 1a

<400>  1

Ala Val Trp Asp Lys Ala Asp Asp Ser Gly Gly Arg Met Thr Thr Ala 
1               5                   10                  15      


Cys 
    


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, antigen seq 1b

<400>  2

Ala Val Trp Asp Lys Ala Glu Asp Ser Gly Gly Arg Met Thr Thr Ala 
1               5                   10                  15      


Cys 
    


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, antigen seq 1c

<400>  3

Cys Thr Pro His Tyr Ala Lys Lys His Gln Arg Phe Tyr Asp Glu Leu 
1               5                   10                  15      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, antigen seq 1d

<400>  4

Cys Ile Arg Phe Val Ser Ile Asp Asn Lys Lys Arg Asn Ile Glu Ser 
1               5                   10                  15      


Ser Glu Ile Gly Pro 
            20      


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, antigen seq 1e

<400>  5

Pro Gly Gln Met Thr Leu His His Lys Pro Phe Leu Ala Cys 
1               5                   10                  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, antigen seq 1f

<400>  6

Cys Val Leu Glu Ala Leu Lys Asn Tyr Ile 
1               5                   10  


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, antigen seq 3a

<400>  7

Pro Ser Ala Gly Val Ile Leu Gly Cys 
1               5                   


<210>  8
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu Renalase-1 protein (polymorphism resulting in the highlighted

       glutamate amino acid at position 37)

<400>  8

Met Ala Gln Val Leu Ile Val Gly Ala Gly Met Thr Gly Ser Leu Cys 
1               5                   10                  15      


Ala Ala Leu Leu Arg Arg Gln Thr Ser Gly Pro Leu Tyr Leu Ala Val 
            20                  25                  30          


Trp Asp Lys Ala Glu Asp Ser Gly Gly Arg Met Thr Thr Ala Cys Ser 
        35                  40                  45              


Pro His Asn Pro Gln Cys Thr Ala Asp Leu Gly Ala Gln Tyr Ile Thr 
    50                  55                  60                  


Cys Thr Pro His Tyr Ala Lys Lys His Gln Arg Phe Tyr Asp Glu Leu 
65                  70                  75                  80  


Leu Ala Tyr Gly Val Leu Arg Pro Leu Ser Ser Pro Ile Glu Gly Met 
                85                  90                  95      


Val Met Lys Glu Gly Asp Cys Asn Phe Val Ala Pro Gln Gly Ile Ser 
            100                 105                 110         


Ser Ile Ile Lys His Tyr Leu Lys Glu Ser Gly Ala Glu Val Tyr Phe 
        115                 120                 125             


Arg His Arg Val Thr Gln Ile Asn Leu Arg Asp Asp Lys Trp Glu Val 
    130                 135                 140                 


Ser Lys Gln Thr Gly Ser Pro Glu Gln Phe Asp Leu Ile Val Leu Thr 
145                 150                 155                 160 


Met Pro Val Pro Glu Ile Leu Gln Leu Gln Gly Asp Ile Thr Thr Leu 
                165                 170                 175     


Ile Ser Glu Cys Gln Arg Gln Gln Leu Glu Ala Val Ser Tyr Ser Ser 
            180                 185                 190         


Arg Tyr Ala Leu Gly Leu Phe Tyr Glu Ala Gly Thr Lys Ile Asp Val 
        195                 200                 205             


Pro Trp Ala Gly Gln Tyr Ile Thr Ser Asn Pro Cys Ile Arg Phe Val 
    210                 215                 220                 


Ser Ile Asp Asn Lys Lys Arg Asn Ile Glu Ser Ser Glu Ile Gly Pro 
225                 230                 235                 240 


Ser Leu Val Ile His Thr Thr Val Pro Phe Gly Val Thr Tyr Leu Glu 
                245                 250                 255     


His Ser Ile Glu Asp Val Gln Glu Leu Val Phe Gln Gln Leu Glu Asn 
            260                 265                 270         


Ile Leu Pro Gly Leu Pro Gln Pro Ile Ala Thr Lys Cys Gln Lys Trp 
        275                 280                 285             


Arg His Ser Gln Val Thr Asn Ala Ala Ala Asn Cys Pro Gly Gln Met 
    290                 295                 300                 


Thr Leu His His Lys Pro Phe Leu Ala Cys Gly Gly Asp Gly Phe Thr 
305                 310                 315                 320 


Gln Ser Asn Phe Asp Gly Cys Ile Thr Ser Ala Leu Cys Val Leu Glu 
                325                 330                 335     


Ala Leu Lys Asn Tyr Ile 
            340         


<210>  9
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-28-4 full length heavy chain amino
       acid

<400>  9

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Ser Phe Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Tyr Ile Gly Ile Ile Ser Ser Val Gly Ile Thr Arg Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Ala Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Tyr Gly Tyr Ser Gly Asp Val Asn Arg Leu Asp Leu Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val 
            180                 185                 190         


Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr 
        195                 200                 205             


Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr 
225                 230                 235                 240 


Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr 
        275                 280                 285             


Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg 
    290                 295                 300                 


Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile 
305                 310                 315                 320 


Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg 
            340                 345                 350         


Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu 
        355                 360                 365             


Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu 
385                 390                 395                 400 


Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly 
            420                 425                 430         


Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 


<210>  10
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-28-4 full length light chain amino
       acid

<400>  10

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Gln Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Phe Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 


Ile Phe Pro Pro Ser Ala Asp Leu Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 


Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     


Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         


Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 


Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 heavy chain CDR1 amino acid

<400>  11

Leu Ser Ser Phe Ala Val Gly 
1               5           


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 heavy chain CDR2 amino acid

<400>  12

Ile Ile Ser Ser Val Gly Ile Thr Arg Tyr Ala Ser Trp Ala Ala Gly 
1               5                   10                  15      


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 heavy chain CDR3 amino acid

<400>  13

Tyr Gly Tyr Ser Gly Asp Val Asn Arg Leu Asp Leu 
1               5                   10          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 light chain CDR1 amino acid

<400>  14

Ser Gln Ser Val Tyr Asp Asn Asn Asn Leu Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 light chain CDR2 amino acid

<400>  15

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 light chain CDR3 amino acid

<400>  16

Leu Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Phe Ala 
1               5                   10              


<210>  17
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-37-10 full length heavy chain 
       amino acid

<400>  17

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Gly Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Asp Tyr Ala Ile Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Tyr Ile Ala Ile Ile Gly Ser Ser Gly Asp Thr Phe Tyr Ala Thr Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Pro Arg Tyr Ala Gly Thr Thr Asp Tyr His Asp Ala Phe Asp Pro Trp 
        115                 120                 125             


Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro 
            180                 185                 190         


Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser 
        195                 200                 205             


Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys 
225                 230                 235                 240 


Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro 
    290                 295                 300                 


Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu 
305                 310                 315                 320 


Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys 
                325                 330                 335     


Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro 
        355                 360                 365             


Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys 
385                 390                 395                 400 


Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln 
            420                 425                 430         


Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 460     


<210>  18
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-37-10 full length light chain 
       amino acid

<400>  18

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Glu Val Val Met Thr Gln Thr Pro Ala 
            20                  25                  30          


Ser Met Glu Ala Pro Met Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
        35                  40                  45              


Ser Gln Asn Ile Tyr Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Val Tyr Lys Ala Ser Thr Leu Thr Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Ile Asn Tyr Ser Ile Tyr Asn His Tyr Asn Ile Ile Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ala Asp Leu Val Ala Thr Gly Thr Val Thr Ile Val 
145                 150                 155                 160 


Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val 
                165                 170                 175     


Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln 
            180                 185                 190         


Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln 
    210                 215                 220                 


Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235             


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 heavy chain CDR1 amino acid

<400>  19

Leu Ser Asp Tyr Ala Ile Ile 
1               5           


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 heavy chain CDR2 amino acid

<400>  20

Ile Ile Gly Ser Ser Gly Asp Thr Phe Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 heavy chain CDR3 amino acid

<400>  21

Arg Tyr Ala Gly Thr Thr Asp Tyr His Asp Ala Phe Asp Pro 
1               5                   10                  


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 light chain CDR1 amino acid

<400>  22

Ser Gln Asn Ile Tyr Asn Tyr Leu Ser 
1               5                   


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 light chain CDR2 amino acid

<400>  23

Lys Ala Ser Thr Leu Thr Ser 
1               5           


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 light chain CDR3 amino acid

<400>  24

Gln Ile Asn Tyr Ser Ile Tyr Asn His Tyr Asn Ile Ile 
1               5                   10              


<210>  25
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-26-1 full length heavy chain amino
       acid

<400>  25

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro 
            20                  25                  30          


Thr Asp Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Ser Tyr Gly Val Thr Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Leu Ile Gly Asp Arg Gly Thr Thr Phe Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val 
                85                  90                  95      


Thr Leu Lys Met Thr Arg Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Ala Arg Gly Ser Gly Tyr Gly Ala Arg Ile Trp Gly Pro Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Trp Gln Pro Lys Ala Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser 
        195                 200                 205             


Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro 
225                 230                 235                 240 


Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr 
        275                 280                 285             


Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln 
    290                 295                 300                 


Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His 
305                 310                 315                 320 


Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln 
            340                 345                 350         


Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu 
        355                 360                 365             


Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val 
            420                 425                 430         


Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455         


<210>  26
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-26-1 full length light chain amino
       acid

<400>  26

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Lys Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Thr Ser Lys Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala Phe Gly Gly Gly Thr 
        115                 120                 125             


Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ala Asp Leu Val Ala Thr Gly Thr Val Thr Ile Val Cys 
145                 150                 155                 160 


Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp 
                165                 170                 175     


Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn 
            180                 185                 190         


Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser 
        195                 200                 205             


Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly 
    210                 215                 220                 


Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235         


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 heavy chain CDR1 amino acid

<400>  27

Leu Ser Ser Tyr Gly Val Thr 
1               5           


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 heavy chain CDR2 amino acid

<400>  28

Leu Ile Gly Asp Arg Gly Thr Thr Phe Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 heavy chain CDR3 amino acid

<400>  29

Gly Ser Gly Tyr Gly Ala Arg Ile 
1               5               


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 light chain CDR1 amino acid

<400>  30

Ser Gln Ser Val Tyr Lys Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 light chain CDR2 amino acid

<400>  31

Glu Thr Ser Lys Leu Ala Ser 
1               5           


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 light chain CDR3 amino acid

<400>  32

Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala 
1               5                   10      


<210>  33
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-42-7 full length heavy chain amino
       acid

<400>  33

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro 
            20                  25                  30          


Thr Asp Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
        35                  40                  45              


Thr Tyr Gly Val Thr Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Leu Ile Gly Asp Arg Gly Thr Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Val Asn Gly Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val 
                85                  90                  95      


Thr Leu Lys Met Thr Arg Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Ala Arg Gly Ser Gly Tyr Gly Ala Arg Ile Trp Gly Pro Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ala Ser Trp Gln Pro Lys Ala Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser 
        195                 200                 205             


Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro 
225                 230                 235                 240 


Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr 
        275                 280                 285             


Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln 
    290                 295                 300                 


Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His 
305                 310                 315                 320 


Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln 
            340                 345                 350         


Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu 
        355                 360                 365             


Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val 
            420                 425                 430         


Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455         


<210>  34
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-42-7 full length light chain amino
       acid

<400>  34

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Met Ser Ala Ala Leu Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Thr Val Tyr Asn Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Thr Ser Lys Leu Ser Ser 
65                  70                  75                  80  


Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala Phe Gly Gly Gly Thr 
        115                 120                 125             


Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ala Asp Leu Val Ala Thr Gly Thr Val Thr Ile Val Cys 
145                 150                 155                 160 


Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp 
                165                 170                 175     


Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn 
            180                 185                 190         


Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser 
        195                 200                 205             


Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly 
    210                 215                 220                 


Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235         


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 heavy chain CDR1 amino acid

<400>  35

Leu Thr Thr Tyr Gly Val Thr 
1               5           


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 heavy chain CDR2 amino acid

<400>  36

Leu Ile Gly Asp Arg Gly Thr Thr Tyr Tyr Ala Ser Trp Val Asn Gly 
1               5                   10                  15      


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 heavy chain CDR3 amino acid

<400>  37

Gly Ser Gly Tyr Gly Ala Arg Ile 
1               5               


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 light chain CDR1 amino acid

<400>  38

Ser Gln Thr Val Tyr Asn Asn Asn Tyr Leu Ser 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 light chain CDR2 amino acid

<400>  39

Glu Thr Ser Lys Leu Ser Ser 
1               5           


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 light chain CDR3 amino acid

<400>  40

Gln Gly Gly Tyr Ser Gly Val Asp Phe Met 
1               5                   10  


<210>  41
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 3A-5-2 full length heavy chain amino 
       acid

<400>  41

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
        35                  40                  45              


Asn Tyr His Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Tyr Ile Gly Ile Ile Phe Asn Gly Gly Thr Tyr Tyr Ala Arg Trp Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
                85                  90                  95      


Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            100                 105                 110         


Gly Asp Gly Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
    130                 135                 140                 


Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly 
                165                 170                 175     


Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro 
    210                 215                 220                 


Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg 
        275                 280                 285             


Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg 
    290                 295                 300                 


Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr 
            340                 345                 350         


Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu 
        355                 360                 365             


Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp 
    370                 375                 380                 


Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro 
                405                 410                 415     


Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  42
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 3A-5-2 full length light chain amino 
       acid

<400>  42

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ala Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Val Phe Asn Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                85                  90                  95      


Leu Thr Met Ser Gly Val Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Ser Phe Asp Cys Asn Ser Gly Asp Cys Val Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 


Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 


Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     


Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         


Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 


Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 heavy chain CDR1 amino acid

<400>  43

Leu Asn Asn Tyr His Ile Tyr 
1               5           


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 heavy chain CDR2 amino acid

<400>  44

Ile Ile Phe Asn Gly Gly Thr Tyr Tyr Ala Arg Trp Thr Lys Gly 
1               5                   10                  15  


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 heavy chain CDR3 amino acid

<400>  45

Gly Asp Gly Ile 
1               


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 light chain CDR1 amino acid

<400>  46

Ser Gln Ser Val Phe Asn Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 light chain CDR2 amino acid

<400>  47

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 light chain CDR3 amino acid

<400>  48

Ala Gly Ser Phe Asp Cys Asn Ser Gly Asp Cys Val Ala 
1               5                   10              


<210>  49
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human Renalase-1 nucleic acid sequence 
       (Note potential polymorphism at nucleotide position 111)

<400>  49
atggcgcagg tgctgatcgt gggcgccggg atgacaggaa gcttgtgcgc tgcgctgctg       60

aggaggcaga cgtccggtcc cttgtacctt gctgtgtggg acaaggctga ggactcaggg      120

ggaagaatga ctacagcctg cagtcctcat aatcctcagt gcacagctga cttgggtgct      180

cagtacatca cctgcactcc tcattatgcc aaaaaacacc aacgttttta tgatgaactg      240

ttagcctatg gcgttttgag gcctctaagc tcgcctattg aaggaatggt gatgaaagaa      300

ggagactgta actttgtggc acctcaagga atttcttcaa ttattaagca ttacttgaaa      360

gaatcaggtg cagaagtcta cttcagacat cgtgtgacac agatcaacct aagagatgac      420

aaatgggaag tatccaaaca aacaggctcc cctgagcagt ttgatcttat tgttctcaca      480

atgccagttc ctgagattct gcagcttcaa ggtgacatca ccaccttaat tagtgaatgc      540

caaaggcagc aactggaggc tgtgagctac tcctctcgat atgctctggg cctcttttat      600

gaagctggta cgaagattga tgtcccttgg gctgggcagt acatcaccag taatccctgc      660

atacgcttcg tctccattga taataagaag cgcaatatag agtcatcaga aattgggcct      720

tccctcgtga ttcacaccac tgtcccattt ggagttacat acttggaaca cagcattgag      780

gatgtgcaag agttagtctt ccagcagctg gaaaacattt tgccgggttt gcctcagcca      840

attgctacca aatgccaaaa atggagacat tcacaggtta caaatgctgc tgccaactgt      900

cctggccaaa tgactctgca tcacaaacct ttccttgcat gtggagggga tggatttact      960

cagtccaact ttgatggctg catcacttct gccctatgtg ttctggaagc tttaaagaat     1020

tatatttaa                                                             1029


<210>  50
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human Renalase-2 amino acid sequence 
       (polymorphism resulting in the highlighted glutamate amino acid 
       at position 37)

<400>  50

Met Ala Gln Val Leu Ile Val Gly Ala Gly Met Thr Gly Ser Leu Cys 
1               5                   10                  15      


Ala Ala Leu Leu Arg Arg Gln Thr Ser Gly Pro Leu Tyr Leu Ala Val 
            20                  25                  30          


Trp Asp Lys Ala Glu Asp Ser Gly Gly Arg Met Thr Thr Ala Cys Ser 
        35                  40                  45              


Pro His Asn Pro Gln Cys Thr Ala Asp Leu Gly Ala Gln Tyr Ile Thr 
    50                  55                  60                  


Cys Thr Pro His Tyr Ala Lys Lys His Gln Arg Phe Tyr Asp Glu Leu 
65                  70                  75                  80  


Leu Ala Tyr Gly Val Leu Arg Pro Leu Ser Ser Pro Ile Glu Gly Met 
                85                  90                  95      


Val Met Lys Glu Gly Asp Cys Asn Phe Val Ala Pro Gln Gly Ile Ser 
            100                 105                 110         


Ser Ile Ile Lys His Tyr Leu Lys Glu Ser Gly Ala Glu Val Tyr Phe 
        115                 120                 125             


Arg His Arg Val Thr Gln Ile Asn Leu Arg Asp Asp Lys Trp Glu Val 
    130                 135                 140                 


Ser Lys Gln Thr Gly Ser Pro Glu Gln Phe Asp Leu Ile Val Leu Thr 
145                 150                 155                 160 


Met Pro Val Pro Glu Ile Leu Gln Leu Gln Gly Asp Ile Thr Thr Leu 
                165                 170                 175     


Ile Ser Glu Cys Gln Arg Gln Gln Leu Glu Ala Val Ser Tyr Ser Ser 
            180                 185                 190         


Arg Tyr Ala Leu Gly Leu Phe Tyr Glu Ala Gly Thr Lys Ile Asp Val 
        195                 200                 205             


Pro Trp Ala Gly Gln Tyr Ile Thr Ser Asn Pro Cys Ile Arg Phe Val 
    210                 215                 220                 


Ser Ile Asp Asn Lys Lys Arg Asn Ile Glu Ser Ser Glu Ile Gly Pro 
225                 230                 235                 240 


Ser Leu Val Ile His Thr Thr Val Pro Phe Gly Val Thr Tyr Leu Glu 
                245                 250                 255     


His Ser Ile Glu Asp Val Gln Glu Leu Val Phe Gln Gln Leu Glu Asn 
            260                 265                 270         


Ile Leu Pro Gly Leu Pro Gln Pro Ile Ala Thr Lys Cys Gln Lys Trp 
        275                 280                 285             


Arg His Ser Gln Val Pro Ser Ala Gly Val Ile Leu Gly Cys Ala Lys 
    290                 295                 300                 


Ser Pro Trp Met Met Ala Ile Gly Phe Pro Ile 
305                 310                 315 


<210>  51
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Human Ren 2 nucleic acid sequence (Note 
       potential polymorphism at nucleotide position 111)

<400>  51
atggcgcagg tgctgatcgt gggcgccggg atgacaggaa gcttgtgcgc tgcgctgctg       60

aggaggcaga cgtccggtcc cttgtacctt gctgtgtggg acaaggctga ggactcaggg      120

ggaagaatga ctacagcctg cagtcctcat aatcctcagt gcacagctga cttgggtgct      180

cagtacatca cctgcactcc tcattatgcc aaaaaacacc aacgttttta tgatgaactg      240

ttagcctatg gcgttttgag gcctctaagc tcgcctattg aaggaatggt gatgaaagaa      300

ggagactgta actttgtggc acctcaagga atttcttcaa ttattaagca ttacttgaaa      360

gaatcaggtg cagaagtcta cttcagacat cgtgtgacac agatcaacct aagagatgac      420

aaatgggaag tatccaaaca aacaggctcc cctgagcagt ttgatcttat tgttctcaca      480

atgccagttc ctgagattct gcagcttcaa ggtgacatca ccaccttaat tagtgaatgc      540

caaaggcagc aactggaggc tgtgagctac tcctctcgat atgctctggg cctcttttat      600

gaagctggta cgaagattga tgtcccttgg gctgggcagt acatcaccag taatccctgc      660

atacgcttcg tctccattga taataagaag cgcaatatag agtcatcaga aattgggcct      720

tccctcgtga ttcacaccac tgtcccattt ggagttacat acttggaaca cagcattgag      780

gatgtgcaag agttagtctt ccagcagctg gaaaacattt tgccgggttt gcctcagcca      840

attgctacca aatgccaaaa atggagacat tcacaggtac caagtgctgg tgtgattcta      900

ggatgtgcga agagcccctg gatgatggcg attggatttc ccatc                      945


<210>  52
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-28-4 full length heavy chain 
       nucleic acid

<400>  52
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagtctctg gattctccct cagtagtttt gcagtgggct gggtccgcca ggctccaggg      180

aaggggctgg aatacatcgg aatcattagt agtgttggta ttacacgcta cgcgagctgg      240

gcggccggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa aatcaccagt      300

ccgacaaccg aggacacggc cacctatttt tgtgccagat atggttatag tggtgatgtt      360

aatcggttgg atctctgggg ccagggcacc ctggtcaccg tctcctcagg gcaacctaag      420

gctccatcag tcttcccact ggccccctgc tgcggggaca cacccagctc cacggtgacc      480

ctgggctgcc tggtcaaagg gtacctcccg gagccagtga ccgtgacctg gaactcgggc      540

accctcacca atggggtacg caccttcccg tccgtccggc agtcctcagg cctctactcg      600

ctgagcagcg tggtgagcgt gacctcaagc agccagcccg tcacctgcaa cgtggcccac      660

ccagccacca acaccaaagt ggacaagacc gttgcgccct cgacatgcag caagcccacg      720

tgcccacccc ctgaactcct ggggggaccg tctgtcttca tcttcccccc aaaacccaag      780

gacaccctca tgatctcacg cacccccgag gtcacatgcg tggtggtgga cgtgagccag      840

gatgaccccg aggtgcagtt cacatggtac ataaacaacg agcaggtgcg caccgcccgg      900

ccgccgctac gggagcagca gttcaacagc acgatccgcg tggtcagcac cctccccatc      960

gcgcaccagg actggctgag gggcaaggag ttcaagtgca aagtccacaa caaggcactc     1020

ccggccccca tcgagaaaac catctccaaa gccagagggc agcccctgga gccgaaggtc     1080

tacaccatgg gccctccccg ggaggagctg agcagcaggt cggtcagcct gacctgcatg     1140

atcaacggct tctacccttc cgacatctcg gtggagtggg agaagaacgg gaaggcagag     1200

gacaactaca agaccacgcc ggccgtgctg gacagcgacg gctcctactt cctctacagc     1260

aagctctcag tgcccacgag tgagtggcag cggggcgacg tcttcacctg ctccgtgatg     1320

cacgaggcct tgcacaacca ctacacgcag aagtccatct cccgctctcc gggtaaatga     1380


<210>  53
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-28-4 full length light chain 
       nucleic acid

<400>  53
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactgca tcgcccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca attgccaggc cagtcagagt gtttatgata acaacaactt agcctggtat      180

cagcagaaac cagggcagcc tcccaagcaa ctgatctatg gtgcatccac tctggcatct      240

ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

ggcgtgcagt gtgacgatgc tgccacttac tactgtctag gcgaatttag ttgtagtagt      360

gctgattgtt ttgctttcgg cggagggacc gaggtggtcg tcaaaggtga tccagttgca      420

cctactgtcc tcatcttccc accatctgct gatcttgtgg caactggaac agtcaccatc      480

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      540

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      600

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      660

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgttag      720


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 heavy chain CDR1 nucleic acid

<400>  54
ctcagtagtt ttgcagtggg c                                                 21


<210>  55
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 heavy chain CDR2 nucleic acid

<400>  55
atcattagta gtgttggtat tacacgctac gcgagctggg cggccggc                    48


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 heavy chain CDR3 nucleic acid

<400>  56
tatggttata gtggtgatgt taatcggttg gatctc                                 36


<210>  57
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 light chain CDR1 nucleic acid

<400>  57
agtcagagtg tttatgataa caacaactta gcc                                    33


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 light chain CDR2 nucleic acid

<400>  58
ggtgcatcca ctctggcatc t                                                 21


<210>  59
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-28-4 light chain CDR3 nucleic acid

<400>  59
ctaggcgaat ttagttgtag tagtgctgat tgttttgct                              39


<210>  60
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-37-10 full length heavy chain 
       nucleic acid

<400>  60
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcgcctggtc acgcctggag gatccctgac actcacctgc      120

acagtctctg gattctccct cagtgactat gcaataatct gggtccgcca ggctccaggg      180

aaggggctgg aatacatcgc aattattggt agtagtggtg acacattcta cgcgacctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa aatgaccagt      300

ctgacagccg cggacacggc cacctatttc tgtgccccac gttatgctgg tactactgat      360

tatcatgatg cttttgatcc ctggggccca ggcactttgg tcaccgtctc ctcagggcaa      420

cctaaggctc catcagtctt cccactggcc ccctgctgcg gggacacacc cagctccacg      480

gtgaccctgg gctgcctggt caaagggtac ctcccggagc cagtgaccgt gacctggaac      540

tcgggcaccc tcaccaatgg ggtacgcacc ttcccgtccg tccggcagtc ctcaggcctc      600

tactcgctga gcagcgtggt gagcgtgacc tcaagcagcc agcccgtcac ctgcaacgtg      660

gcccacccag ccaccaacac caaagtggac aagaccgttg cgccctcgac atgcagcaag      720

cccacgtgcc caccccctga actcctgggg ggaccgtctg tcttcatctt ccccccaaaa      780

cccaaggaca ccctcatgat ctcacgcacc cccgaggtca catgcgtggt ggtggacgtg      840

agccaggatg accccgaggt gcagttcaca tggtacataa acaacgagca ggtgcgcacc      900

gcccggccgc cgctacggga gcagcagttc aacagcacga tccgcgtggt cagcaccctc      960

cccatcgcgc accaggactg gctgaggggc aaggagttca agtgcaaagt ccacaacaag     1020

gcactcccgg cccccatcga gaaaaccatc tccaaagcca gagggcagcc cctggagccg     1080

aaggtctaca ccatgggccc tccccgggag gagctgagca gcaggtcggt cagcctgacc     1140

tgcatgatca acggcttcta cccttccgac atctcggtgg agtgggagaa gaacgggaag     1200

gcagaggaca actacaagac cacgccggcc gtgctggaca gcgacggctc ctacttcctc     1260

tacagcaagc tctcagtgcc cacgagtgag tggcagcggg gcgacgtctt cacctgctcc     1320

gtgatgcacg aggccttgca caaccactac acgcagaagt ccatctcccg ctctccgggt     1380

aaatga                                                                1386


<210>  61
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1D-37-10 full length light chain 
       nucleic acid

<400>  61
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

agatgtgccg aagtagtgat gacccagact ccagcctcca tggaggcacc tatgggaggc      120

acagtcacca tcaagtgcca ggccagtcag aacatttaca actacttatc ctggtatcag      180

cagaaaccag ggcagcctcc caagctccta gtctacaagg cctccactct gacttctggg      240

gtcccgtcgc gcttcaaagg cagtggatct gggacacagt tcactctcac catcagcgac      300

ctggagtgtg ccgatgctgc cacttactac tgtcaaatca attactctat ttataatcat      360

tataatatta tttttggcgg agggaccgag gtggtcgtca agggtgatcc agttgcacct      420

actgtcctca tcttcccacc atctgctgat cttgtggcaa ctggaacagt caccatcgtg      480

tgtgtggcga ataaatactt tcccgatgtc accgtcacct gggaggtgga tggcaccacc      540

caaacaactg gcatcgagaa cagtaaaaca ccgcagaatt ctgcagattg tacctacaac      600

ctcagcagca ctctgacact gaccagcaca cagtacaaca gccacaaaga gtacacctgc      660

aaggtgaccc agggcacgac ctcagtcgtc cagagcttca ataggggtga ctgttag         717


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 heavy chain CDR1 nucleic acid

<400>  62
ctcagtgact atgcaataat c                                                 21


<210>  63
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 heavy chain CDR2 nucleic acid

<400>  63
attattggta gtagtggtga cacattctac gcgacctggg cgaaaggc                    48


<210>  64
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 heavy chain CDR3 nucleic acid

<400>  64
cgttatgctg gtactactga ttatcatgat gcttttgatc cc                          42


<210>  65
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 light chain CDR1 nucleic acid

<400>  65
agtcagaaca tttacaacta cttatcc                                           27


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 light chain CDR2 nucleic acid

<400>  66
aaggcctcca ctctgacttc t                                                 21


<210>  67
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1D-37-10 light chain CDR3 nucleic acid

<400>  67
caaatcaatt actctattta taatcattat aatattatt                              39


<210>  68
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-26-1 full length heavy chain 
       nucleic acid

<400>  68
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtgaagg agtccgaggg aggtctcttc aagccaacgg ataccctgac actcacctgc      120

acagtctctg gattctccct cagtagctat ggagtgacct gggtccgcca ggctccaggg      180

aacgggctgg agtggatcgg attgattggt gatcgtggta ctacgttcta cgcgagctgg      240

gcgaaaagcc gatccaccat caccagaaac accaacctga acacggtgac tctgaaaatg      300

accaggctga cagccgcgga cacggccacc tatttctgtg cgagggggag tgggtatggt      360

gctcgcatct ggggcccagg caccctggtc accgtctcct catggcaacc taaggctcca      420

tcagtcttcc cactggcccc ctgctgcggg gacacaccca gctccacggt gaccctgggc      480

tgcctggtca aagggtacct cccggagcca gtgaccgtga cctggaactc gggcaccctc      540

accaatgggg tacgcacctt cccgtccgtc cggcagtcct caggcctcta ctcgctgagc      600

agcgtggtga gcgtgacctc aagcagccag cccgtcacct gcaacgtggc ccacccagcc      660

accaacacca aagtggacaa gaccgttgcg ccctcgacat gcagcaagcc cacgtgccca      720

ccccctgaac tcctgggggg accgtctgtc ttcatcttcc ccccaaaacc caaggacacc      780

ctcatgatct cacgcacccc cgaggtcaca tgcgtggtgg tggacgtgag ccaggatgac      840

cccgaggtgc agttcacatg gtacataaac aacgagcagg tgcgcaccgc ccggccgccg      900

ctacgggagc agcagttcaa cagcacgatc cgcgtggtca gcaccctccc catcgcgcac      960

caggactggc tgaggggcaa ggagttcaag tgcaaagtcc acaacaaggc actcccggcc     1020

cccatcgaga aaaccatctc caaagccaga gggcagcccc tggagccgaa ggtctacacc     1080

atgggccctc cccgggagga gctgagcagc aggtcggtca gcctgacctg catgatcaac     1140

ggcttctacc cttccgacat ctcggtggag tgggagaaga acgggaaggc agaggacaac     1200

tacaagacca cgccggccgt gctggacagc gacggctcct acttcctcta cagcaagctc     1260

tcagtgccca cgagtgagtg gcagcggggc gacgtcttca cctgctccgt gatgcacgag     1320

gccttgcaca accactacac gcagaagtcc atctcccgct ctccgggtaa atga           1374


<210>  69
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-26-1 full length light chain 
       nucleic acid

<400>  69
atggacacga gggcccccac tcagctcctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactcca tcgcctgtgt ctgcagctgt gggaggcaca      120

gtcaccatca attgccagtc cagtcagagt gtttataaga acaactactt agcctggtat      180

cagcagaaac cagggcagcc tcccaagctc cttatctacg aaacatccaa actggcatct      240

ggggtcccac cgcggttcag cggcagtggg tctgggacac agttcactct caccatcagc      300

agcgtgcagt gtgacgatgc tgccacttac tactgtcaag gcggttatag tggtgttgat      360

tttatggctt tcggcggagg gaccgaggtg gtcgtcaaag gtgatccagt tgcacctact      420

gtcctcatct tcccaccatc tgctgatctt gtggcaactg gaacagtcac catcgtgtgt      480

gtggcgaata aatactttcc cgatgtcacc gtcacctggg aggtggatgg caccacccaa      540

acaactggca tcgagaacag taaaacaccg cagaattctg cagattgtac ctacaacctc      600

agcagcactc tgacactgac cagcacacag tacaacagcc acaaagagta cacctgcaag      660

gtgacccagg gcacgacctc agtcgtccag agcttcaata ggggtgactg ttag            714


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 heavy chain CDR1 nucleic acid

<400>  70
ctcagtagct atggagtgac c                                                 21


<210>  71
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 heavy chain CDR2 nucleic acid

<400>  71
ttgattggtg atcgtggtac tacgttctac gcgagctggg cgaaaagc                    48


<210>  72
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 heavy chain CDR3 nucleic acid

<400>  72
gggagtgggt atggtgctcg catc                                              24


<210>  73
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 light chain CDR1 nucleic acid

<400>  73
agtcagagtg tttataagaa caactactta gcc                                    33


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 light chain CDR2 nucleic acid

<400>  74
gaaacatcca aactggcatc t                                                 21


<210>  75
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-26-1 light chain CDR3 nucleic acid

<400>  75
caaggcggtt atagtggtgt tgattttatg gct                                    33


<210>  76
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-42-7 full length heavy chain 
       nucleic acid

<400>  76
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtgaagg agtccgaggg aggtctcttc aagccaacgg ataccctgac actcacctgc      120

acagtctctg gattctccct cactacctat ggagtgacct gggtccgcca ggctccaggg      180

aatgggctgg agtggatcgg attgattggt gatcgcggta ccacttacta cgcgagctgg      240

gtgaatggcc gatccaccat caccagaaac accaacctga acacggtgac tctgaaaatg      300

accaggctga cagccgcgga cacggccacc tatttctgtg cgagggggag tggatatggt      360

gctcgcatct ggggcccagg caccctggtc accgtcgcct catggcaacc taaggctcca      420

tcagtcttcc cactggcccc ctgctgcggg gacacaccca gctccacggt gaccctgggc      480

tgcctggtca aagggtacct cccggagcca gtgaccgtga cctggaactc gggcaccctc      540

accaatgggg tacgcacctt cccgtccgtc cggcagtcct caggcctcta ctcgctgagc      600

agcgtggtga gcgtgacctc aagcagccag cccgtcacct gcaacgtggc ccacccagcc      660

accaacacca aagtggacaa gaccgttgcg ccctcgacat gcagcaagcc cacgtgccca      720

ccccctgaac tcctgggggg accgtctgtc ttcatcttcc ccccaaaacc caaggacacc      780

ctcatgatct cacgcacccc cgaggtcaca tgcgtggtgg tggacgtgag ccaggatgac      840

cccgaggtgc agttcacatg gtacataaac aacgagcagg tgcgcaccgc ccggccgccg      900

ctacgggagc agcagttcaa cagcacgatc cgcgtggtca gcaccctccc catcgcgcac      960

caggactggc tgaggggcaa ggagttcaag tgcaaagtcc acaacaaggc actcccggcc     1020

cccatcgaga aaaccatctc caaagccaga gggcagcccc tggagccgaa ggtctacacc     1080

atgggccctc cccgggagga gctgagcagc aggtcggtca gcctgacctg catgatcaac     1140

ggcttctacc cttccgacat ctcggtggag tgggagaaga acgggaaggc agaggacaac     1200

tacaagacca cgccggccgt gctggacagc gacggctcct acttcctcta cagcaagctc     1260

tcagtgccca cgagtgagtg gcagcggggc gacgtcttca cctgctccgt gatgcacgag     1320

gccttgcaca accactacac gcagaagtcc atctcccgct ctccgggtaa atga           1374


<210>  77
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 1F-42-7 full length light chain 
       nucleic acid

<400>  77
atggacacga gggcccccac tcagctcctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactcca tcccccatgt ctgcagctct gggaggcaca      120

gtcaccatca attgccagtc cagtcagact gtttataaca ataactactt atcctggtat      180

cagcagaaac cagggcagcc tcccaagctc cttatctacg aaacatccaa actgtcatct      240

ggggtcccac cgcggttcag cggcagtggg tctgggacac agttcactct caccatcagc      300

agcgtgcagt gtgacgatgc tgccacttac tactgtcaag gcggttatag tggtgttgat      360

tttatggctt tcggcggagg gaccgaggtg gtcgtcaaag gtgatccagt tgcacctact      420

gtcctcatct tcccaccatc tgctgatctt gtggcaactg gaacagtcac catcgtgtgt      480

gtggcgaata aatactttcc cgatgtcacc gtcacctggg aggtggatgg caccacccaa      540

acaactggca tcgagaacag taaaacaccg cagaattctg cagattgtac ctacaacctc      600

agcagcactc tgacactgac cagcacacag tacaacagcc acaaagagta cacctgcaag      660

gtgacccagg gcacgacctc agtcgtccag agcttcaata ggggtgactg ttag            714


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 heavy chain CDR1 nucleic acid

<400>  78
ctcactacct atggagtgac c                                                 21


<210>  79
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 heavy chain CDR2 nucleic acid

<400>  79
ttgattggtg atcgcggtac cacttactac gcgagctggg tgaatggc                    48


<210>  80
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 heavy chain CDR3 nucleic acid

<400>  80
gggagtggat atggtgctcg catc                                              24


<210>  81
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 light chain CDR1 nucleic acid

<400>  81
agtcagactg tttataacaa taactactta tcc                                    33


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 light chain CDR2 nucleic acid

<400>  82
gaaacatcca aactgtcatc t                                                 21


<210>  83
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 1F-42-7 light chain CDR3 nucleic acid

<400>  83
ggcggttata gtggtgttga ttttatggct                                        30


<210>  84
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 3A-5-2 full length heavy chain 
       nucleic acid

<400>  84
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagtctctg gattctccct caataactac cacatatact gggtccgcca ggctccagga      180

aaggggctgg aatacatcgg aatcattttc aatggtggca catattacgc gagatggaca      240

aaaggccgat tcaccatctc caaaacctcg accacggtgg atctgaaaat gaccagtctg      300

acaaccgagg acacggccac ctatttctgt gccagagggg acggcatctg gggcccaggc      360

accctggtca ccgtctcctt agggcaacct aaggctccat cagtcttccc actggccccc      420

tgctgcgggg acacacccag ctccacggtg accctgggct gcctggtcaa agggtacctc      480

ccggagccag tgaccgtgac ctggaactcg ggcaccctca ccaatggggt acgcaccttc      540

ccgtccgtcc ggcagtcctc aggcctctac tcgctgagca gcgtggtgag cgtgacctca      600

agcagccagc ccgtcacctg caacgtggcc cacccagcca ccaacaccaa agtggacaag      660

accgttgcgc cctcgacatg cagcaagccc acgtgcccac cccctgaact cctgggggga      720

ccgtctgtct tcatcttccc cccaaaaccc aaggacaccc tcatgatctc acgcaccccc      780

gaggtcacat gcgtggtggt ggacgtgagc caggatgacc ccgaggtgca gttcacatgg      840

tacataaaca acgagcaggt gcgcaccgcc cggccgccgc tacgggagca gcagttcaac      900

agcacgatcc gcgtggtcag caccctcccc atcgcgcacc aggactggct gaggggcaag      960

gagttcaagt gcaaagtcca caacaaggca ctcccggccc ccatcgagaa aaccatctcc     1020

aaagccagag ggcagcccct ggagccgaag gtctacacca tgggccctcc ccgggaggag     1080

ctgagcagca ggtcggtcag cctgacctgc atgatcaacg gcttctaccc ttccgacatc     1140

tcggtggagt gggagaagaa cgggaaggca gaggacaact acaagaccac gccggccgtg     1200

ctggacagcg acggctccta cttcctctac agcaagctct cagtgcccac gagtgagtgg     1260

cagcggggcg acgtcttcac ctgctccgtg atgcacgagg ccttgcacaa ccactacacg     1320

cagaagtcca tctcccgctc tccgggtaaa tga                                  1353


<210>  85
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, mAb 3A-5-2 full length light chain 
       nucleic acid

<400>  85
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactcca gcctccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca attgccaggc cagtcagagt gtttttaata acaactattt agcctggtat      180

cagcagaaac cagggcagcc tcccaagcgc ctgatctatt ctgcatccac tctggcgtct      240

ggggtctcat cgcggttcaa aggcagtgga tctgggacag aattcactct gaccatgagt      300

ggcgtggagt gtgacgatgc tgccacttac tactgtgcag gcagttttga ttgtaatagt      360

ggtgattgtg ttgctttcgg cggagggacc gaggtggtgg tcaagggtga tccagttgca      420

cctactgtcc tcatcttccc accagctgct gatcaggtgg caactggaac agtcaccatc      480

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      540

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      600

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      660

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgttag      720


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 heavy chain CDR1 nucleic acid

<400>  86
ctcaataact accacatata c                                                 21


<210>  87
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 heavy chain CDR2 nucleic acid

<400>  87
atcattttca atggtggcac atattacgcg agatggacaa aaggc                       45


<210>  88
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 heavy chain CDR3 nucleic acid

<400>  88
ggggacggca tc                                                           12


<210>  89
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 light chain CDR1 nucleic acid

<400>  89
agtcagagtg tttttaataa caactattta gcc                                    33


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 light chain CDR2 nucleic acid

<400>  90
tctgcatcca ctctggcgtc t                                                 21


<210>  91
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, 3A-5-2 light chain CDR3 nucleic acid

<400>  91
gcaggcagtt ttgattgtaa tagtggtgat tgtgttgct                              39


<210>  92
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Alternative Human Renalase-1 protein 
       (polymorphism resulting in the highlighted aspartate amino acid 
       at position 37)

<400>  92

Met Ala Gln Val Leu Ile Val Gly Ala Gly Met Thr Gly Ser Leu Cys 
1               5                   10                  15      


Ala Ala Leu Leu Arg Arg Gln Thr Ser Gly Pro Leu Tyr Leu Ala Val 
            20                  25                  30          


Trp Asp Lys Ala Asp Asp Ser Gly Gly Arg Met Thr Thr Ala Cys Ser 
        35                  40                  45              


Pro His Asn Pro Gln Cys Thr Ala Asp Leu Gly Ala Gln Tyr Ile Thr 
    50                  55                  60                  


Cys Thr Pro His Tyr Ala Lys Lys His Gln Arg Phe Tyr Asp Glu Leu 
65                  70                  75                  80  


Leu Ala Tyr Gly Val Leu Arg Pro Leu Ser Ser Pro Ile Glu Gly Met 
                85                  90                  95      


Val Met Lys Glu Gly Asp Cys Asn Phe Val Ala Pro Gln Gly Ile Ser 
            100                 105                 110         


Ser Ile Ile Lys His Tyr Leu Lys Glu Ser Gly Ala Glu Val Tyr Phe 
        115                 120                 125             


Arg His Arg Val Thr Gln Ile Asn Leu Arg Asp Asp Lys Trp Glu Val 
    130                 135                 140                 


Ser Lys Gln Thr Gly Ser Pro Glu Gln Phe Asp Leu Ile Val Leu Thr 
145                 150                 155                 160 


Met Pro Val Pro Glu Ile Leu Gln Leu Gln Gly Asp Ile Thr Thr Leu 
                165                 170                 175     


Ile Ser Glu Cys Gln Arg Gln Gln Leu Glu Ala Val Ser Tyr Ser Ser 
            180                 185                 190         


Arg Tyr Ala Leu Gly Leu Phe Tyr Glu Ala Gly Thr Lys Ile Asp Val 
        195                 200                 205             


Pro Trp Ala Gly Gln Tyr Ile Thr Ser Asn Pro Cys Ile Arg Phe Val 
    210                 215                 220                 


Ser Ile Asp Asn Lys Lys Arg Asn Ile Glu Ser Ser Glu Ile Gly Pro 
225                 230                 235                 240 


Ser Leu Val Ile His Thr Thr Val Pro Phe Gly Val Thr Tyr Leu Glu 
                245                 250                 255     


His Ser Ile Glu Asp Val Gln Glu Leu Val Phe Gln Gln Leu Glu Asn 
            260                 265                 270         


Ile Leu Pro Gly Leu Pro Gln Pro Ile Ala Thr Lys Cys Gln Lys Trp 
        275                 280                 285             


Arg His Ser Gln Val Thr Asn Ala Ala Ala Asn Cys Pro Gly Gln Met 
    290                 295                 300                 


Thr Leu His His Lys Pro Phe Leu Ala Cys Gly Gly Asp Gly Phe Thr 
305                 310                 315                 320 


Gln Ser Asn Phe Asp Gly Cys Ile Thr Ser Ala Leu Cys Val Leu Glu 
                325                 330                 335     


Ala Leu Lys Asn Tyr Ile 
            340         


<210>  93
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Alternative Human Renalase-1 nucleic acid
       sequence (Note potential polymorphism at nucleotide position 111)

<400>  93
atggcgcagg tgctgatcgt gggcgccggg atgacaggaa gcttgtgcgc tgcgctgctg       60

acgaggcaga cgtccggtcc cttgtacctt gctgtgtggg acaaggctga ggactcaggg      120

ggaagaatga ctacagcctg cagtcctcat aatcctcagt gcacagctga cttgggtgct      180

cagtacatca cctgcactcc tcattatgcc aaaaaacacc aacgttttta tgatgaactg      240

ttagcctatg gcgttttgag gcctctaagc tcgcctattg aaggaatggt gatgaaagaa      300

ggagactgta actttgtggc acctcaagga atttcttcaa ttattaagca ttacttgaaa      360

gaatcaggtg cagaagtcta cttcagacat cgtgtgacac agatcaacct aagagatgac      420

aaatgggaag tatccaaaca aacaggctcc cctgagcagt ttgatcttat tgttctcaca      480

atgccagttc ctgagattct gcagcttcaa ggtgacatca ccaccttaat tagtgaatgc      540

caaaggcagc aactggaggc tgtgagctac tcctctcgat atgctctggg cctcttttat      600

gaagctggta cgaagattga tgtcccttgg gctgggcagt acatcaccag taatccctgc      660

atacgcttcg tctccattga taataagaag cgcaatatag agtcatcaga aattgggcct      720

tccctcgtga ttcacaccac tgtcccattt ggagttacat acttggaaca cagcattgag      780

gatgtgcaag agttagtctt ccagcagctg gaaaacattt tgccgggttt gcctcagcca      840

attgctacca aatgccaaaa atggagacat tcacaggtta caaatgctgc tgccaactgt      900

cctggccaaa tgactctgca tcacaaacct ttccttgcat gtggagggga tggatttact      960

cagtccaact ttgatggctg catcacttct gccctatgtg ttctggaagc tttaaagaat     1020

tatatttaa                                                             1029


<210>  94
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Alternative Human Renalase-2 amino acid 
       sequence (polymorphism resulting in the highlighted aspartate 
       amino acid at position 37)

<400>  94

Met Ala Gln Val Leu Ile Val Gly Ala Gly Met Thr Gly Ser Leu Cys 
1               5                   10                  15      


Ala Ala Leu Leu Arg Arg Gln Thr Ser Gly Pro Leu Tyr Leu Ala Val 
            20                  25                  30          


Trp Asp Lys Ala Asp Asp Ser Gly Gly Arg Met Thr Thr Ala Cys Ser 
        35                  40                  45              


Pro His Asn Pro Gln Cys Thr Ala Asp Leu Gly Ala Gln Tyr Ile Thr 
    50                  55                  60                  


Cys Thr Pro His Tyr Ala Lys Lys His Gln Arg Phe Tyr Asp Glu Leu 
65                  70                  75                  80  


Leu Ala Tyr Gly Val Leu Arg Pro Leu Ser Ser Pro Ile Glu Gly Met 
                85                  90                  95      


Val Met Lys Glu Gly Asp Cys Asn Phe Val Ala Pro Gln Gly Ile Ser 
            100                 105                 110         


Ser Ile Ile Lys His Tyr Leu Lys Glu Ser Gly Ala Glu Val Tyr Phe 
        115                 120                 125             


Arg His Arg Val Thr Gln Ile Asn Leu Arg Asp Asp Lys Trp Glu Val 
    130                 135                 140                 


Ser Lys Gln Thr Gly Ser Pro Glu Gln Phe Asp Leu Ile Val Leu Thr 
145                 150                 155                 160 


Met Pro Val Pro Glu Ile Leu Gln Leu Gln Gly Asp Ile Thr Thr Leu 
                165                 170                 175     


Ile Ser Glu Cys Gln Arg Gln Gln Leu Glu Ala Val Ser Tyr Ser Ser 
            180                 185                 190         


Arg Tyr Ala Leu Gly Leu Phe Tyr Glu Ala Gly Thr Lys Ile Asp Val 
        195                 200                 205             


Pro Trp Ala Gly Gln Tyr Ile Thr Ser Asn Pro Cys Ile Arg Phe Val 
    210                 215                 220                 


Ser Ile Asp Asn Lys Lys Arg Asn Ile Glu Ser Ser Glu Ile Gly Pro 
225                 230                 235                 240 


Ser Leu Val Ile His Thr Thr Val Pro Phe Gly Val Thr Tyr Leu Glu 
                245                 250                 255     


His Ser Ile Glu Asp Val Gln Glu Leu Val Phe Gln Gln Leu Glu Asn 
            260                 265                 270         


Ile Leu Pro Gly Leu Pro Gln Pro Ile Ala Thr Lys Cys Gln Lys Trp 
        275                 280                 285             


Arg His Ser Gln Val Pro Ser Ala Gly Val Ile Leu Gly Cys Ala Lys 
    290                 295                 300                 


Ser Pro Trp Met Met Ala Ile Gly Phe Pro Ile 
305                 310                 315 


<210>  95
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Alternative Human Renalase-2 nucleic acid
       sequence (Note potential polymorphism at nucleotide position 111)

<400>  95
atggcgcagg tgctgatcgt gggcgccggg atgacaggaa gcttgtgcgc tgcgctgctg       60

acgaggcaga cgtccggtcc cttgtacctt gctgtgtggg acaaggctga ggactcaggg      120

ggaagaatga ctacagcctg cagtcctcat aatcctcagt gcacagctga cttgggtgct      180

cagtacatca cctgcactcc tcattatgcc aaaaaacacc aacgttttta tgatgaactg      240

ttagcctatg gcgttttgag gcctctaagc tcgcctattg aaggaatggt gatgaaagaa      300

ggagactgta actttgtggc acctcaagga atttcttcaa ttattaagca ttacttgaaa      360

gaatcaggtg cagaagtcta cttcagacat cgtgtgacac agatcaacct aagagatgac      420

aaatgggaag tatccaaaca aacaggctcc cctgagcagt ttgatcttat tgttctcaca      480

atgccagttc ctgagattct gcagcttcaa ggtgacatca ccaccttaat tagtgaatgc      540

caaaggcagc aactggaggc tgtgagctac tcctctcgat atgctctggg cctcttttat      600

gaagctggta cgaagattga tgtcccttgg gctgggcagt acatcaccag taatccctgc      660

atacgcttcg tctccattga taataagaag cgcaatatag agtcatcaga aattgggcct      720

tccctcgtga ttcacaccac tgtcccattt ggagttacat acttggaaca cagcattgag      780

gatgtgcaag agttagtctt ccagcagctg gaaaacattt tgccgggttt gcctcagcca      840

attgctacca aatgccaaaa atggagacat tcacaggtac caagtgctgg tgtgattcta      900

ggatgtgcga agagcccctg gatgatggcg attggatttc ccatc                      945


<210>  96
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN452

M28 L1

<400>  96
tgccgtgcca gtcagagcgt gtatgacaac aacaacgtag cctggtatca a                51


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN452

M28 L1

<400>  97

Cys Arg Ala Ser Gln Ser Val Tyr Asp Asn Asn Asn Val Ala Trp Tyr 
1               5                   10                  15      


Gln 
    


<210>  98
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN453

M42 L1

<400>  98
tgccgtgcca gtcagaccgt gtataacaac aactacgtag cctggtatca a                51


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN453

M42 L1

<400>  99

Cys Arg Ala Ser Gln Thr Val Tyr Asn Asn Asn Tyr Val Ala Trp Tyr 
1               5                   10                  15      


Gln 
    


<210>  100
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN454

M28 L2

<400>  100
aagcttctga tttacggcgc cagcaccctc tactctggag tc                          42


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN454

M28 L2

<400>  101

Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Tyr Ser Gly Val 
1               5                   10                  


<210>  102
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN455

M42 L2

<400>  102
aagcttctga tttacgaaac cagcaaactc tactctggag tc                          42


<210>  103
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN455

M42 L2

<400>  103

Lys Leu Leu Ile Tyr Glu Thr Ser Lys Leu Tyr Ser Gly Val 
1               5                   10                  


<210>  104
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN456

M28 L3

<400>  104
gcaacttatt actgtctggg cgaattcagc tgcagcagcg ctgactgctt cgccttcgga       60

cagggtacc                                                               69


<210>  105
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN456

M28 L3

<400>  105

Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys 
1               5                   10                  15      


Phe Ala Phe Gly Gln Gly Thr 
            20              


<210>  106
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN457

M42 L3

<400>  106
gcaacttatt actgtcaggg cggctacagc ggcgtggact tcatggcttt cggacagggt       60

acc                                                                     63


<210>  107
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN457

M42 L3

<400>  107

Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala 
1               5                   10                  15      


Phe Gly Gln Gly Thr 
            20      


<210>  108
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN458

M28 H1

<400>  108
gcttctggct tcaacctgag cagcttcgcc gttcactggg tgcgtcag                    48


<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN458

M28 H1

<400>  109

Ala Ser Gly Phe Asn Leu Ser Ser Phe Ala Val His Trp Val Arg Gln 
1               5                   10                  15      


<210>  110
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN459

M42 H1

<400>  110
gcttctggct tcaacctgac cacctacggc gttcactggg tgcgtcag                    48


<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN459

M42 H1

<400>  111

Ala Ser Gly Phe Asn Leu Thr Thr Tyr Gly Val His Trp Val Arg Gln 
1               5                   10                  15      


<210>  112
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN460

M28 H2

<400>  112
ctggaatggg ttgcaatcat cagcagcgtt ggcatcaccc gctatgccga tagcgtc          57


<210>  113
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN460

M28 H2

<400>  113

Leu Glu Trp Val Ala Ile Ile Ser Ser Val Gly Ile Thr Arg Tyr Ala 
1               5                   10                  15      


Asp Ser Val 
            


<210>  114
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN461

M42 H2

<400>  114
ctggaatggg ttgcactgat cggcgatcgc ggcaccacct attatgccga tagcgtc          57


<210>  115
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN461

M42 H2

<400>  115

Leu Glu Trp Val Ala Leu Ile Gly Asp Arg Gly Thr Thr Tyr Tyr Ala 
1               5                   10                  15      


Asp Ser Val 
            


<210>  116
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN462

M28 H3

<400>  116
tattattgtg ctcgctatgg ctatagcggc gacgtgaacc gcctggacct gtggggtcaa       60

ggaacc                                                                  66


<210>  117
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN462

M28 H3

<400>  117

Tyr Tyr Cys Ala Arg Tyr Gly Tyr Ser Gly Asp Val Asn Arg Leu Asp 
1               5                   10                  15      


Leu Trp Gly Gln Gly Thr 
            20          


<210>  118
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN463

M42 H3

<400>  118
tattattgtg ctcgcggcag cggctatggc gctcgcatct ggggtcaagg aacc             54


<210>  119
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN463

M42 H3

<400>  119

Tyr Tyr Cys Ala Arg Gly Ser Gly Tyr Gly Ala Arg Ile Trp Gly Gln 
1               5                   10                  15      


Gly Thr 
        


<210>  120
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN464

M28 HC71

<400>  120
cgtttcacta taagcaaaga cacatccaaa aac                                    33


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN464

M28 HC71

<400>  121

Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn 
1               5                   10      


<210>  122
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN465

M42 HC71

<400>  122
cgtttcacta taagccgcga cacatccaaa aac                                    33


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN465

M42 HC71

<400>  123

Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn 
1               5                   10      


<210>  124
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN498

M28 L3 STOP

<400>  124
gcaacttatt actgttaatg ataattcgga cagggtacc                              39


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN498

M28 L3 STOP


<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  STOP

<400>  125

Ala Thr Tyr Tyr Cys Xaa Xaa Xaa Phe Gly Gln Gly Thr 
1               5                   10              


<210>  126
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN484

M28 H1 STOP

<400>  126
gcttctggct tcaattaatg ataacactgg gtgcgtcag                              39


<210>  127
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN484

M28 H1 STOP


<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  STOP

<400>  127

Ala Ser Gly Phe Asn Xaa Xaa Xaa His Trp Val Arg Gln 
1               5                   10              


<210>  128
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN467

M28 and M42

H2 STOP

<400>  128
ctggaatggg ttgcatgata atgatatgcc gatagcgtc                              39


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN467

M28 and M42

H2 STOP


<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  STOP

<400>  129

Leu Glu Trp Val Ala Xaa Xaa Xaa Tyr Ala Asp Ser Val 
1               5                   10              


<210>  130
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN485

M28 and M42

H3 STOP

<400>  130
tattattgtg ctcgctaatg ataatggggt caaggaacc                              39


<210>  131
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN485

M28 and M42

H3 STOP


<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  STOP

<400>  131

Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Trp Gly Gln Gly Thr 
1               5                   10              


<210>  132
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN469

M42 L1 STOP

<400>  132
tgccgtgcca gtcagtgata atgagtagcc tggtatcaa                              39


<210>  133
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN469

M42 L1 STOP


<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  STOP

<400>  133

Cys Arg Ala Ser Gln Xaa Xaa Xaa Val Ala Trp Tyr Gln 
1               5                   10              


<210>  134
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN466

M42 H1 STOP

<400>  134
gcttctggct tcaactgata atgacactgg gtgcgtcag                              39


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN466

M42 H1 STOP


<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  STOP

<400>  135

Ala Ser Gly Phe Asn Xaa Xaa Xaa His Trp Val Arg Gln 
1               5                   10              


<210>  136
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN492

M28 L3

randomization

<400>  136
gcaacttatt actgtctggg cgaattcagc tgcagcagcg ctgactgctt cgccttcgga       60

cagggtacc                                                               69


<210>  137
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN492

M28 L3

randomization

<400>  137

Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys 
1               5                   10                  15      


Phe Ala Phe Gly Gln Gly Thr 
            20              


<210>  138
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN488

M28 H1

randomization

<400>  138
gcttctggct tcaacctgag cagcttcgcc gttcactggg tgcgtcag                    48


<210>  139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN488

M28 H1

randomization

<400>  139

Ala Ser Gly Phe Asn Leu Ser Ser Phe Ala Val His Trp Val Arg Gln 
1               5                   10                  15      


<210>  140
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN489

M28 H2

randomization

<400>  140
ctggaatggg ttgcaatcat cagcagcgtt ggcatcaccc gctatgccga tagcgtc          57


<210>  141
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN489

M28 H2

randomization

<400>  141

Leu Glu Trp Val Ala Ile Ile Ser Ser Val Gly Ile Thr Arg Tyr Ala 
1               5                   10                  15      


Asp Ser Val 
            


<210>  142
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN490

M28 H3

randomization

<400>  142
tattattgtg ctcgctatgg ctatagcggc gacgtgaacc gcctggacct gtggggtcaa       60

ggaacc                                                                  66


<210>  143
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN490

M28 H3

randomization

<400>  143

Tyr Tyr Cys Ala Arg Tyr Gly Tyr Ser Gly Asp Val Asn Arg Leu Asp 
1               5                   10                  15      


Leu Trp Gly Gln Gly Thr 
            20          


<210>  144
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN496

M42 L1

randomization

<400>  144
tgccgtgcca gtcagaccgt gtataacaac aactacgtag cctggtatca a                51


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN496

M42 L1

randomization

<400>  145

Cys Arg Ala Ser Gln Thr Val Tyr Asn Asn Asn Tyr Val Ala Trp Tyr 
1               5                   10                  15      


Gln 
    


<210>  146
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN493

M42 H1

randomization

<400>  146
gcttctggct tcaacctgac cacctacggc gttcactggg tgcgtcag                    48


<210>  147
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN493

M42 H1

randomization

<400>  147

Ala Ser Gly Phe Asn Leu Thr Thr Tyr Gly Val His Trp Val Arg Gln 
1               5                   10                  15      


<210>  148
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN494

M42 H2

randomization

<400>  148
ctggaatggg ttgcactgat cggcgatcgc ggcaccacct attatgccga tagcgtc          57


<210>  149
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN494

M42 H2

randomization

<400>  149

Leu Glu Trp Val Ala Leu Ile Gly Asp Arg Gly Thr Thr Tyr Tyr Ala 
1               5                   10                  15      


Asp Ser Val 
            


<210>  150
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN495

M42 H3

randomization

<400>  150
tattattgtg ctcgcggcag cggctatggc gctcgcatct ggggtcaagg aacc             54


<210>  151
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, BN495

M42 H3

randomization

<400>  151

Tyr Tyr Cys Ala Arg Gly Ser Gly Tyr Gly Ala Arg Ile Trp Gly Gln 
1               5                   10                  15      


Gly Thr 
        


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28 Parental CDR-L1

<400>  152

Ser Val Tyr Asp Asn Asn Asn 
1               5           


<210>  153
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28 Parental CDR-L2

<400>  153

Gly Ala Ser Thr 
1               


<210>  154
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28 Parental CDR-L3

<400>  154

Leu Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Phe Ala 
1               5                   10              


<210>  155
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28 Parental CDR-H1

<400>  155

Leu Ser Ser Phe Ala Val 
1               5       


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28 Parental CDR-H2

<400>  156

Ile Ile Ser Ser Val Gly Ile Thr Arg 
1               5                   


<210>  157
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28 Parental CDR-H3

<400>  157

Tyr Gly Tyr Ser Gly Asp Val Asn Arg Leu Asp Leu 
1               5                   10          


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K2 CDR-L1

<400>  158

Ser Val Tyr Asp Asn Asn Asn 
1               5           


<210>  159
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K2 CDR-L2

<400>  159

Gly Ala Ser Thr 
1               


<210>  160
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K2 CDR-L3

<400>  160

Leu Gly Glu Gly Pro Cys Ser Val Thr Asp Cys Leu Ile 
1               5                   10              


<210>  161
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K2 CDR-H1

<400>  161

Leu Ser Ser Phe Ala Val 
1               5       


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K2 CDR-H2

<400>  162

Leu Ile Gly Val Arg Gly Ser Leu Tyr 
1               5                   


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K2 CDR-H3

<400>  163

His Trp Tyr Ser Gly Gly Val Val Arg Leu Asp Ala 
1               5                   10          


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K5 CDR-L1

<400>  164

Ser Val Tyr Asp Asn Asn Asn 
1               5           


<210>  165
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K5 CDR-L2

<400>  165

Gly Ala Ser Thr 
1               


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K5 CDR-L3

<400>  166

Leu Gly Glu Gly Pro Cys Ser Val Thr Asp Cys Leu Ile 
1               5                   10              


<210>  167
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K5 CDR-H1

<400>  167

Leu Ser Ser Phe Ala Val 
1               5       


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K5 CDR-H2

<400>  168

Leu Ile Ser Gly Arg Gly Thr Arg Phe 
1               5                   


<210>  169
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K5 CDR-H3

<400>  169

His Trp Tyr Ser Gly Gly Val Val Arg Leu Asp Ala 
1               5                   10          


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K9 CDR-L1

<400>  170

Ser Val Tyr Asp Asn Asn Asn 
1               5           


<210>  171
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K9 CDR-L2

<400>  171

Gly Ala Ser Thr 
1               


<210>  172
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K9 CDR-L3

<400>  172

Leu Gly Glu Gly Pro Cys Ser Val Thr Asp Cys Leu Ile 
1               5                   10              


<210>  173
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K9 CDR-H1

<400>  173

Leu Ser Ser Phe Ala Val 
1               5       


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K9 CDR-H2

<400>  174

Ile Ile Ser Ser Val Gly Ile Thr Arg 
1               5                   


<210>  175
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K9 CDR-H3

<400>  175

His Trp Tyr Ser Gly Gly Val Val Arg Leu Asp Ala 
1               5                   10          


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K13 CDR-L1

<400>  176

Ser Val Tyr Asp Asn Asn Asn 
1               5           


<210>  177
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K13 CDR-L2

<400>  177

Gly Ala Ser Thr 
1               


<210>  178
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K13 CDR-L3

<400>  178

Leu Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Phe Ala 
1               5                   10              


<210>  179
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K13 CDR-H1

<400>  179

Leu Ser Ser Phe Ala Val 
1               5       


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K13 CDR-H2

<400>  180

Leu Ile Gly Val Arg Gly Ser Leu Tyr 
1               5                   


<210>  181
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K13 CDR-H3

<400>  181

His Trp Tyr Ser Gly Gly Val Val Arg Leu Asp Ala 
1               5                   10          


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K14 CDR-L1

<400>  182

Ser Val Tyr Asp Asn Asn Asn 
1               5           


<210>  183
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K14 CDR-L2

<400>  183

Gly Ala Ser Thr 
1               


<210>  184
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K14 CDR-L3

<400>  184

Leu Gly Glu Gly Pro Cys Ser Val Thr Asp Cys Leu Ile 
1               5                   10              


<210>  185
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K14 CDR-H1

<400>  185

Leu Ser Ser Phe Ala Val 
1               5       


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K14 CDR-H2

<400>  186

Leu Ile Ser Gly Arg Gly Thr Arg Phe 
1               5                   


<210>  187
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K14 CDR-H3

<400>  187

Tyr Gly Tyr Ser Gly Asp Val Asn Arg Leu Asp Leu 
1               5                   10          


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K16 CDR-L1

<400>  188

Ser Val Tyr Asp Asn Asn Asn 
1               5           


<210>  189
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K16 CDR-L2

<400>  189

Gly Ala Ser Thr 
1               


<210>  190
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K16 CDR-L3

<400>  190

Leu Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Phe Ala 
1               5                   10              


<210>  191
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K16 CDR-H1

<400>  191

Leu Ser Ser Phe Ala Val 
1               5       


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K16 CDR-H2

<400>  192

Leu Ile Ser Gly Arg Gly Thr Arg Phe 
1               5                   


<210>  193
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-K16 CDR-H3

<400>  193

His Trp Tyr Ser Gly Gly Val Val Arg Leu Asp Ala 
1               5                   10          


<210>  194
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 Parental CDR-L1

<400>  194

Thr Val Tyr Asn Asn Asn Tyr 
1               5           


<210>  195
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 Parental CDR-L2

<400>  195

Glu Thr Ser Lys 
1               


<210>  196
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 Parental CDR-L3

<400>  196

Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala 
1               5                   10      


<210>  197
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 Parental CDR-H1

<400>  197

Leu Thr Thr Tyr Gly Val 
1               5       


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 Parental CDR-H2

<400>  198

Leu Ile Gly Asp Arg Gly Thr Thr Tyr 
1               5                   


<210>  199
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 Parental CDR-H3

<400>  199

Gly Ser Gly Tyr Gly Ala Arg Ile 
1               5               


<210>  200
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K31 CDR-L1

<400>  200

Ser Val Tyr Arg Asn Asn Tyr 
1               5           


<210>  201
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K31 CDR-L2

<400>  201

Glu Thr Ser Lys 
1               


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K31 CDR-L3

<400>  202

Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala 
1               5                   10      


<210>  203
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K31 CDR-H1

<400>  203

Met Ser Ser Glu Arg Arg 
1               5       


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K31 CDR-H2

<400>  204

Leu Ile Arg Asp Arg Gly Trp Asn Tyr 
1               5                   


<210>  205
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K31 CDR-H3

<400>  205

Gly Ile Cys Tyr Cys Ala Arg Ser 
1               5               


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K34 CDR-L1

<400>  206

Ser Val Tyr Arg Asn Asn Tyr 
1               5           


<210>  207
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K34 CDR-L2

<400>  207

Glu Thr Ser Lys 
1               


<210>  208
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K34 CDR-L3

<400>  208

Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala 
1               5                   10      


<210>  209
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K34 CDR-H1

<400>  209

Leu Thr Thr Tyr Gly Val 
1               5       


<210>  210
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K34 CDR-H2

<400>  210

Leu Ile Arg Asp Arg Gly Trp Asn Tyr 
1               5                   


<210>  211
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K34 CDR-H3

<400>  211

Gly Ile Cys Tyr Cys Ala Arg Ser 
1               5               


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K35 CDR-L1

<400>  212

Thr Val Tyr Asn Asn Asn Tyr 
1               5           


<210>  213
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K35 L2

<400>  213

Glu Thr Ser Lys 
1               


<210>  214
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K35 L3

<400>  214

Gln Gly Gly Tyr Ser Gly Val Asp Phe Met Ala 
1               5                   10      


<210>  215
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K35 H1

<400>  215

Met Ser Ser Glu Arg Arg 
1               5       


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K35 H2

<400>  216

Leu Ile Arg Asp Arg Gly Trp Asn Tyr 
1               5                   


<210>  217
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42-K35 H3

<400>  217

Gly Ile Cys Tyr Cys Ala Arg Ser 
1               5               


<210>  218
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-humanized Fv sequence Heavy chain

<400>  218
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caatctgagc agcttcgccg ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcaatc atcagcagcg ttggcatcac ccgctatgcc      180

gatagcgtca agggccgttt cactataagc aaagacacat ccaaaaacac agcctaccta      240

caaatgaaca gcttaagagc tgaggacact gccgtctatt attgtgctcg ctatggctat      300

agcggcgacg tgaaccgcct ggacctgtgg ggtcaaggaa ccctggtcac cgtctcctcg      360


<210>  219
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-humanized Fv sequence Heavy chain

<400>  219

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Ser Phe 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Ser Val Gly Ile Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Tyr Ser Gly Asp Val Asn Arg Leu Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  220
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-humanized Fv sequence Light chain

<400>  220
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gagcgtgtat gacaacaaca acgtagcctg gtatcaacag      120

aaaccaggaa aagctccgaa gcttctgatt tacggcgcca gcaccctcta ctctggagtc      180

ccttctcgct tctctggtag ccgttccggg acggatttca ctctgaccat cagcagtctg      240

cagccggaag acttcgcaac ttattactgt ctgggcgaat tcagctgcag cagcgctgac      300

tgcttcgcct tcggacaggg taccaaggtg gagatcaaac ga                         342


<210>  221
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M28-humanized Fv sequence Light chain

<400>  221

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Tyr Asp Asn 
            20                  25                  30          


Asn Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Thr Leu Tyr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Glu Phe Ser Cys 
                85                  90                  95      


Ser Ser Ala Asp Cys Phe Ala Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  222
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 humanized Fv sequence Heavy chain

<400>  222
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctgacc acctacggcg ttcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcactg atcggcgatc gcggcaccac ctattatgcc      180

gatagcgtca agggccgttt cactataagc cgcgacacat ccaaaaacac agcctaccta      240

caaatgaaca gcttaagagc tgaggacact gccgtctatt attgtgctcg cggcagcggc      300

tatggcgctc gcatctgggg tcaaggaacc ctggtcaccg tctcctcg                   348


<210>  223
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 humanized Fv sequence Heavy chain

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Gly Asp Arg Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ser Gly Tyr Gly Ala Arg Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  224
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 humanized Fv sequence Light chain

<400>  224
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gaccgtgtat aacaacaact acgtagcctg gtatcaacag      120

aaaccaggaa aagctccgaa gcttctgatt tacgaaacca gcaaactcta ctctggagtc      180

ccttctcgct tctctggtag ccgttccggg acggatttca ctctgaccat cagcagtctg      240

cagccggaag acttcgcaac ttattactgt cagggcggct acagcggcgt ggacttcatg      300

gctttcggac agggtaccaa ggtggagatc aaacga                                336


<210>  225
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, M42 humanized Fv sequence Light chain

<400>  225

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Thr Ser Lys Leu Tyr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Ser Gly 
                85                  90                  95      


Val Asp Phe Met Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


