                         SEQUENCE LISTING

<110>  Julius-Maximilians-Universitt Wrzburg
 
<120>  Tumor necrosis factor (TNF) receptor superfamily (TNFRSF) 
       receptor-activating antibody fusion proteins with Fc 
       R-independent agonistic activity (TNFRSF receptor-activating 
       antibody fusion proteins with Fc R-independent agonistic 
       activity; TRAAFFIAA)

<130>  209681

<150>  EP 17210849.0
<151>  2017-12-28

<150>  EP 18189937.8
<151>  2018-08-21

<160>  167   

<170>  PatentIn version 3.5

<210>  1
<211>  2892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40-Flag-VH-heavy-full-scTNF80(mu)-pCR3 (N297A)

<400>  1
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggatatc      120

cagctccagc agtctggccc tggactcgtc aaaccatctc agagcctgtc tctcacctgt      180

tctgtcaccg gatactccat caccaccaac tacaactgga attggattcg gcagtttcct      240

gggaacaaac tcgaatggat gggatacatc cgatacgacg gcactagtga atacacccca      300

tctctcaaaa atcgggtgtc cattacccgg gacacttcta tgaaccagtt ctttctccga      360

ctcacctctg tgacacctga ggataccgcc acatactact gtgctagact ggactactgg      420

gggcagggaa cactggtgac cgtgtcatct ggatccagca gcgcctctac aaagggcccc      480

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      540

tgcctcgtga aggactactt tcccgagccc gtgaccgtgt cctggaactc tggcgctctg      600

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      660

agcgtcgtga cagtgcccag cagctctctg ggcacccaga cctacatctg caacgtgaac      720

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      780

cacacctgtc ccccttgtcc tgcccccgaa ctgctgggag gcccttccgt gttcctgttc      840

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      900

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa      960

gtgcacaacg ccaagaccaa gcctagagag gaacagtacg ccagcaccta ccgggtggtg     1020

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1080

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1140

cgcgaacccc aggtgtacac actgccccca agcagggacg agctgaccaa gaaccaggtg     1200

tccctgacct gtctcgtgaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1260

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1320

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1380

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1440

agccccggca aggaattcga gttcacacgg gacaaacctg tggctcatgt ggtggccaat     1500

catcaggtgg aggaacagct ggaatggctg agtcagagag caaacgccct gctggcaaat     1560

gggatggacc tcaaagacaa tcagctcgtg gtgcctgccg atggactgta cctggtgtac     1620

tctcaggtcc tgtttaaggg acagggatgc cccgattacg tgctgctcac ccacactgtg     1680

tcacgcttcg ccatctcata ccaggagaaa gtcaatctcc tctccgccgt gaaatcacca     1740

tgtcctaagg atactcccga gggagccgaa ctgaaacctt ggtacgaacc catctacctg     1800

ggcggcgtgt ttcagctgga gaaaggcgat cagctctccg ccgaagtgaa tctgcccaaa     1860

tacctcaact ttagggaatc cggacaggtc tactttggcg tgattgccct gggaggcgga     1920

tctggaggag gctctggcgg gggatctggg ggcggatccg acaaacctgt ggcacacgtc     1980

gtggcaaacc atcaggtcga ggaacagctc gagtggctgt cacagagggc caatgccctg     2040

ctggcaaatg gaatggatct gaaggataat cagctcgtcg tgcctgccga cggcctctac     2100

ctcgtctact ctcaggtcct ctttaaggga cagggctgcc ccgactacgt cctgctcact     2160

cataccgtga gtcgcttcgc tatttcatac caggaaaaag tcaacctgct gagtgctgtg     2220

aaatctcctt gccctaagga tacccctgag ggagccgaac tcaaaccatg gtacgagcca     2280

atctacctcg gaggagtgtt tcagctggaa aaaggggatc agctctccgc cgaagtcaac     2340

ctccccaaat acctcaattt ccgggaatcc ggacaggtgt actttggagt cattgccctg     2400

ggaggcggct ctggcggggg atctggagga ggctccggag gaggcagtga caaacccgtc     2460

gctcacgtgg tggcaaatca tcaggtcgag gaacagctgg aatggctgtc tcagagagca     2520

aacgctctcc tcgccaatgg aatggatctc aaggacaacc agctcgtcgt ccctgccgat     2580

ggactctacc tggtctactc tcaggtgctc tttaagggac agggatgccc cgattacgtc     2640

ctgctcacac acaccgtgtc tcgctttgct atttcatacc aggagaaagt caatctgctg     2700

tctgccgtca aatctccttg tccaaaagac acacccgagg gagccgaact caaaccttgg     2760

tacgagccaa tctacctggg gggagtgttt cagctggaga agggggatca gctctccgcc     2820

gaagtgaatc tcccaaaata cctcaatttt cgggaatccg gacaggtcta ctttggagtg     2880

attgccctgt ag                                                         2892


<210>  2
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40-Flag-VH-heavy-full-pCR3 (hIgG1)

<400>  2
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggatatc      120

cagctccagc agtctggccc tggactcgtc aaaccatctc agagcctgtc tctcacctgt      180

tctgtcaccg gatactccat caccaccaac tacaactgga attggattcg gcagtttcct      240

gggaacaaac tcgaatggat gggatacatc cgatacgacg gcactagtga atacacccca      300

tctctcaaaa atcgggtgtc cattacccgg gacacttcta tgaaccagtt ctttctccga      360

ctcacctctg tgacacctga ggataccgcc acatactact gtgctagact ggactactgg      420

gggcagggaa cactggtgac cgtgtcatct ggatcctcta gcgccagcac aaagggcccc      480

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      540

tgcctcgtga aggactactt tcccgagccc gtgacagtgt cctggaactc tggcgccctg      600

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      660

agcgtcgtga ctgtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      720

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      780

cacacctgtc ccccttgtcc tgcccctgaa ctgctgggcg gaccttccgt gttcctgttc      840

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      900

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa      960

gtgcacaacg ccaagaccaa gcccagagag gaacagtaca acagcaccta ccgggtggtg     1020

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1080

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1140

cgcgaacccc aggtgtacac actgcctccc agcagggacg agctgaccaa gaaccaggtg     1200

tccctgacct gtctcgtgaa aggcttctac ccctccgata tcgccgtgga atgggagagc     1260

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1320

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1380

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1440

agccccggca agtaa                                                      1455


<210>  3
<211>  2189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40-Flag-VH-heavy-full-scFv-anti-CD20-pCR3 (N297A)

<400>  3
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggatatc      120

cagctccagc agtctggccc tggactcgtc aaaccatctc agagcctgtc tctcacctgt      180

tctgtcaccg gatactccat caccaccaac tacaactgga attggattcg gcagtttcct      240

gggaacaaac tcgaatggat gggatacatc cgatacgacg gcactagtga atacacccca      300

tctctcaaaa atcgggtgtc cattacccgg gacacttcta tgaaccagtt ctttctccga      360

ctcacctctg tgacacctga ggataccgcc acatactact gtgctagact ggactactgg      420

gggcagggaa cactggtgac cgtgtcatct ggatccagca gcgcctctac aaagggcccc      480

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      540

tgcctcgtga aggactactt tcccgagccc gtgaccgtgt cctggaactc tggcgctctg      600

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      660

agcgtcgtga cagtgcccag cagctctctg ggcacccaga cctacatctg caacgtgaac      720

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      780

cacacctgtc ccccttgtcc tgcccccgaa ctgctgggag gcccttccgt gttcctgttc      840

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      900

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa      960

gtgcacaacg ccaagaccaa gcctagagag gaacagtacg ccagcaccta ccgggtggtg     1020

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1080

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1140

cgcgaacccc aggtgtacac actgccccca agcagggacg agctgaccaa gaaccaggtg     1200

tccctgacct gtctcgtgaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1260

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1320

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1380

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1440

agccccggca aggaattcca ggtacaactg cagcagcctg gggctgagct ggtgaagcct     1500

ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg     1560

cactgggtaa aacagacacc tggtcggggc ctggaatgga ttggagctat ttatcccgga     1620

aatggtgata cttcctacaa tcagaagttc aaaggcaagg ccacattgac tgcagacaaa     1680

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaggactc tgcggtctat     1740

tactgtgcaa gatcgactta ctacggcggt gactggtact tcaatgtctg gggcgcaggg     1800

accacggtca ccgtctcttc aggaggaggc ggatccggcg gaggcggaag cggtggcgga     1860

ggctctcaaa ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag     1920

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tccactggtt ccagcagaag     1980

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct     2040

gttcgcttca gtggcagtgg gtctgggact tcttactctc tcacaatcag cagagtggag     2100

gcgaagatgc tgccacttat tactgccagc agtggactag taacccaccc acgttcggag     2160

gggggaccaa gctggaaatc aaacgttaa                                       2189


<210>  4
<211>  2874
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40-Flag-VH-heavy-full-scBaff-pCR3 (N297A)

<400>  4
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggatatc      120

cagctccagc agtctggccc tggactcgtc aaaccatctc agagcctgtc tctcacctgt      180

tctgtcaccg gatactccat caccaccaac tacaactgga attggattcg gcagtttcct      240

gggaacaaac tcgaatggat gggatacatc cgatacgacg gcactagtga atacacccca      300

tctctcaaaa atcgggtgtc cattacccgg gacacttcta tgaaccagtt ctttctccga      360

ctcacctctg tgacacctga ggataccgcc acatactact gtgctagact ggactactgg      420

gggcagggaa cactggtgac cgtgtcatct ggatccagca gcgcctctac aaagggcccc      480

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      540

tgcctcgtga aggactactt tcccgagccc gtgaccgtgt cctggaactc tggcgctctg      600

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      660

agcgtcgtga cagtgcccag cagctctctg ggcacccaga cctacatctg caacgtgaac      720

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      780

cacacctgtc ccccttgtcc tgcccccgaa ctgctgggag gcccttccgt gttcctgttc      840

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      900

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa      960

gtgcacaacg ccaagaccaa gcctagagag gaacagtacg ccagcaccta ccgggtggtg     1020

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1080

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1140

cgcgaacccc aggtgtacac actgccccca agcagggacg agctgaccaa gaaccaggtg     1200

tccctgacct gtctcgtgaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1260

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1320

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1380

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1440

agccccggca agctcgaggg acccgaggaa actgtgactc aggactgtct ccagctcatt     1500

gccgatagtg aaacccctac catccagaaa ggctcttaca ccttcgtgcc atggctgctg     1560

tcattcaaac ggggatctgc tctggaggag aaggaaaaca aaatcctggt caaggaaacc     1620

ggctacttct tcatctacgg ccaggtcctc tacaccgaca aaacatacgc tatggggcat     1680

ctcattcagc ggaaaaaagt ccacgtgttc ggcgacgaac tctctctcgt gacactgttc     1740

cggtgtattc agaacatgcc cgagactctg cccaataata gctgctactc tgctggcatt     1800

gccaaactgg aggagggcga cgaactccag ctggctattc ctagggaaaa tgcccagatt     1860

agcctggacg gggatgtgac attttttggc gccctgaaac tgctgggagg cggagggagt     1920

ggcgggggag gctctggacc tgaggaaact gtgacccagg attgtctcca gctcattgcc     1980

gatagtgaga ctcctaccat tcagaaggga tcttacacct ttgtgccttg gctgctgtct     2040

ttcaaacggg gctctgctct ggaggaaaag gagaacaaaa ttctggtcaa agagactggc     2100

tacttcttca tctacggcca ggtgctgtac accgacaaaa catacgccat gggccatctc     2160

attcagcgga aaaaagtcca cgtgttcggc gacgaactct ctctcgtgac actgttccgg     2220

tgtatccaga acatgcccga gacactgccc aataatagct gctactctgc cggcattgct     2280

aaactggagg agggggacga actccagctg gctattccta gggaaaatgc ccagatttct     2340

ctcgatgggg atgtgacatt cttcggggcc ctcaaactgc tgggaggcgg cggatctggc     2400

ggaggcggga gtcaattcgc agcaggtcca gaagaaacag tcactcaaga ctgcttgcaa     2460

ctgattgcag acagtgaaac accaactata caaaaaggat cttacacatt tgttccatgg     2520

cttctcagct ttaaaagggg aagtgcccta gaagaaaaag agaataaaat attggtcaaa     2580

gaaactggtt acttttttat atatggtcag gttttatata ctgataagac ctacgccatg     2640

ggacatctaa ttcagaggaa gaaggtccat gtctttgggg atgaattgag tctggtgact     2700

ttgtttcgat gtattcaaaa tatgcctgaa acactaccca ataattcctg ctattcagct     2760

ggcattgcaa aactggaaga aggagatgaa ctccaacttg caataccaag agaaaatgca     2820

caaatatcac tggatggaga tgtcacattt tttggtgcat tgaaactgct gtga           2874


<210>  5
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40-Flag-VL-light-full-pCR3

<400>  5
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggacatc      120

gtgatgactc agaacccact gtctctgcct gtgtctctgg gggatgaggc tagcatttct      180

tgccgctcat ctcagtcact ggagaactcc aatggcaaca ccttcctgaa ttggtttttc      240

cagaaacccg gccagtcacc tcagctgctc atctaccgag tgagcaatcg gtttagcgga      300

gtgcccgatc gattctctgg ctccggatct gggaccgact ttaccctgaa aatctcacga      360

gtggaggccg aggatctggg agtgtacttc tgtctccagg tcacacatgt gccttacaca      420

tttggcggcg gaacaactct cgaaatcaaa ggatccgaaa tcaagcgtac ggtggccgct      480

cccagcgtgt tcatcttccc acctagcgac gagcagctga agtccggcac agcctctgtc      540

gtgtgcctgc tgaacaactt ctacccccgc gaggccaagg tgcagtggaa ggtggacaat      600

gccctgcaga gcggcaacag ccaggaaagc gtgaccgagc aggacagcaa ggactccacc      660

tacagcctga gcagcaccct gaccctgagc aaggccgact acgagaagca caaggtgtac      720

gcctgcgaag tgacccacca gggcctgtct agccccgtga ccaagagctt caaccggggc      780

gagtgctaa                                                              789


<210>  6
<211>  1908
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-HC-full-IL2(mu)-pCR3  (hIgG1) ( Flagless)

<400>  6
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatcctct agcgccagca caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgacagtg tcctggaact ctggcgccct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

actgtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccctga actgctgggc ggaccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcccagaga ggaacagtac aacagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgcctcc cagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta cccctccgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattgc ccggtaccgc ccctaccagc agcagcacct ctagctctac agccgaggct     1500

caacaacaac aacaacagca acagcagcag cagcagcacc tggaacagct gctgatggac     1560

ctgcaggaac tgctgagccg gatggaaaac taccggaacc tgaagctgcc ccggatgctg     1620

accttcaagt tctacctgcc caagcaggcc accgagctga aggatctgca gtgcctggaa     1680

gatgagctgg gccccctgag acacgtgctg gatctgaccc agagcaagag ctttcagctg     1740

gaagatgccg agaacttcat cagcaacatc agagtgaccg tcgtgaagct gaagggcagc     1800

gacaacacct tcgagtgcca gttcgacgac gagagcgcta ccgtggtgga cttcctgcgg     1860

agatggatcg ccttctgcca gagcatcatc agcaccagcc cccagtaa                  1908


<210>  7
<211>  2199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-HC-heavy-konst-full-scFv-anti-CD19-pCR3  (N297A) (Flagless)

<400>  7
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatccagc agcgcctcta caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgaccgtg tcctggaact ctggcgctct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

acagtgccca gcagctctct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccccga actgctggga ggcccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac gccagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgccccc aagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattcg acattcagat gacgcagtct ccatcctcca tgtctgtatc tctgggagac     1500

acagtcagca tcacttgcca tgcaagtcag ggcattagca gtaatatagg gtggttgcag     1560

cagaaaccag ggaaatcatt taagggcctg atctatcatg gaaccaactt ggaagatgga     1620

gttccatcaa ggttcagtgg cagtggatct ggagcagatt attctctcac catcagcagc     1680

ctggaatctg aagattttgc agactattac tgtgtacagt atgctcagtt tccgtacacg     1740

ttcggagggg ggaccaagct ggagctgaaa cgtggtggtg gtggttctgg tggtggtggt     1800

tctggcggcg gcggctccag tggtggtgga tcccaggttc agctgcagca atctggacct     1860

gagctggtga agcctggggc ctcagtgaag atttcctgca aagcttctgg ctacgcattc     1920

agtagctctt ggatggactg ggtgaagcag aggcctggac agggtcttga gtggattgga     1980

cggatttatc ctggagatgg agatactaac tacaatggga agttcaaggg caaggccaca     2040

ctgactgcag acaaatcctc cagcacagcc tacatgcagc tcagcagcct gacctctgtg     2100

gactctgcgg tctatttctg tgcaaggtcc attactacgg tagtagggtg gtacttcgat     2160

gtctggggcg cagggaccac ggtcaccgtt tcctcctaa                            2199


<210>  8
<211>  2181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-HC-heavy-konst-full-scFv-anti-CD20-pCR3 (N297A) (Flagless)

<400>  8
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatccagc agcgcctcta caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgaccgtg tcctggaact ctggcgctct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

acagtgccca gcagctctct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccccga actgctggga ggcccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac gccagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgccccc aagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattcc aggtacaact gcagcagcct ggggctgagc tggtgaagcc tggggcctca     1500

gtgaagatgt cctgcaaggc ttctggctac acatttacca gttacaatat gcactgggta     1560

aaacagacac ctggtcgggg cctggaatgg attggagcta tttatcccgg aaatggtgat     1620

acttcctaca atcagaagtt caaaggcaag gccacattga ctgcagacaa atcctccagc     1680

acagcctaca tgcagctcag cagcctgaca tctgaggact ctgcggtcta ttactgtgca     1740

agatcgactt actacggcgg tgactggtac ttcaatgtct ggggcgcagg gaccacggtc     1800

accgtctctt caggaggagg cggatccggc ggaggcggaa gcggtggcgg aggctctcaa     1860

attgttctct cccagtctcc agcaatcctg tctgcatctc caggggagaa ggtcacaatg     1920

acttgcaggg ccagctcaag tgtaagttac atccactggt tccagcagaa gccaggaccc     1980

tcccccaaac cctggattta tgccacatcc aacctggctt ctggagtccc tgttcgcttc     2040

agtggcagtg ggtctgggac ttcttactct ctcacaatca gcagagtgga ggctgaagat     2100

gctgccactt attactgcca gcagtggact agtaacccac ccacgttcgg aggggggacc     2160

aagctggaaa tcaaacgtta a                                               2181


<210>  9
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-HC-heavy-full-pCR3 (IgG1) (Flagless)

<400>  9
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatcctct agcgccagca caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgacagtg tcctggaact ctggcgccct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

actgtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccctga actgctgggc ggaccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcccagaga ggaacagtac aacagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgcctcc cagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta cccctccgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aagtaa                                                                1446


<210>  10
<211>  2724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-HC-heavy-full-scGITRL-pCR3 (N297A)

<400>  10
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatccagc agcgcctcta caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgaccgtg tcctggaact ctggcgctct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

acagtgccca gcagctctct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccccga actgctggga ggcccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac gccagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgccccc aagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattcg gcggagggag cggacagctg gaaactgcca aagaaccctg tatggccaaa     1500

ttcggaccac tgcctagcaa atggcagatg gctagtagcg aacctccatg tgtgaacaaa     1560

gtgagcgatt ggaaactcga gatcctccag aatggactgt acctcatcta cggacaggtc     1620

gccccaaatg ccaattacaa tgatgtggcc ccctttgaag tccggctcta caaaaacaag     1680

gatatgatcc agaccctcac caacaaatcc aaaatccaga atgtgggcgg cacatacgaa     1740

ctccatgtcg gcgataccat cgatctcatt ttcaactctg aacaccaggt gctcaaaaac     1800

aacacctact ggggaatcat cctgctggca aaccctcagt tcatctccgg cggcggctct     1860

ggcggcggat ctggcggagg gagtggcgga ggctcacagc tggagactgc taaagaaccc     1920

tgtatggcaa aattcgggcc cctgccctca aaatggcaga tggcctcctc tgaaccaccc     1980

tgtgtgaaca aagtgagtga ttggaaactg gaaatcctcc agaacggcct ctacctcatc     2040

tacggacagg tggcacccaa tgccaattac aacgacgtgg cacccttcga agtgagactg     2100

tacaaaaaca aggatatgat ccagaccctc accaacaaat caaaaatcca gaatgtcgga     2160

gggacatacg aactccatgt gggagacact atcgacctca ttttcaattc cgaacatcag     2220

gtcctgaaaa acaacactta ctggggcatt attctgctcg ccaatccaca gtttattagt     2280

ggaggcgggg gatctggggg aggctccggc ggagggagtg gaggcggatc tcaattccaa     2340

ttagagactg ctaaggagcc ctgtatggct aagtttggac cattaccctc aaaatggcaa     2400

atggcatctt ctgaacctcc ttgcgtgaat aaggtgtctg actggaagct ggagatactt     2460

cagaatggct tatatttaat ttatggccaa gtggctccca atgcaaacta caatgatgta     2520

gctccttttg aggtgcggct gtataaaaac aaagacatga tacaaactct aacaaacaaa     2580

tctaaaatcc aaaatgtagg agggacttat gaattgcatg ttggggacac catagacttg     2640

atattcaact ctgagcatca ggttctaaaa aataatacat actggggtat cattttacta     2700

gcaaatcccc aattcatctc ctag                                            2724


<210>  11
<211>  3411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-HC-heavy-full-sc(mu)41BBL-pCR3 (N297A)

<400>  11
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatccagc agcgcctcta caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgaccgtg tcctggaact ctggcgctct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

acagtgccca gcagctctct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccccga actgctggga ggcccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac gccagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgccccc aagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattcg gcggtggaag tggtactgaa ccgcgacccg ctctcactat aaccaccagc     1500

cctaacttgg gaacgcggga gaataacgcg gatcaagtaa ccccagtttc ccatatcggg     1560

tgtccaaata ccactcaaca aggatcaccg gtctttgcta agctcctggc gaaaaaccaa     1620

gcgtccctct gtaatacaac ccttaattgg cactcccaag atggggcggg ttcttcatac     1680

ctctcacagg ggctccgata cgaagaagac aaaaaggagt tggtggtcga ctcaccagga     1740

ctttactatg tattcctgga gttgaagctc tctcctacat tcaccaatac cggtcacaaa     1800

gtacagggtt gggtgagcct tgtgctccag gcgaagccgc aggtggacga cttcgacaac     1860

cttgcactca ctgtagagct gttcccttgt tccatggaga ataaattggt ggaccgctct     1920

tggagtcagc tcctcctcct caaggcgggt catcgattga gcgttggcct tcgggcatat     1980

cttcatgggg cgcaagatgc ataccgcgat tgggaattgt cataccccaa cacgacctct     2040

tttggcctgt ttctggtcaa acccgacaat ccgtgggaag gtgggggaag cggagggggt     2100

tcaggaggag gatctggggg aggttcaact gaaccgaggc ccgcgcttac tatcacgact     2160

tccccaaatc tggggactag ggaaaacaat gccgatcagg tcactcctgt tagtcacatt     2220

ggttgtccta atacgaccca gcaaggctct ccggtgtttg ccaaactgtt ggccaaaaat     2280

caggcgtcac tttgtaatac aacgctcaac tggcatagtc aggatggggc cggctcctca     2340

tacttgtctc aaggtcttag gtacgaagaa gataagaagg agctggtggt agacagcccc     2400

gggctctact atgtgttcct ggagctcaaa ctgtcaccga cgttcactaa caccggtcat     2460

aaggtacagg gttgggtatc cttggtgttg caagcaaaac cccaggtgga cgatttcgat     2520

aatcttgcgc ttactgtaga gctctttcca tgttcaatgg aaaataaact ggtcgatagg     2580

agctggtccc aacttctcct tcttaaagct ggccatcgcc tgagtgttgg cctgagagcg     2640

tatcttcatg gggcgcagga cgcttaccgg gattgggaac tgtcataccc aaacaccacc     2700

agctttgggc tcttccttgt aaagccagac aatccgtggg aggggggagg cgggagtggg     2760

ggcgggtctg gagggggcag tggggggggt agtacggagc cgcgccccgc cctgaccatc     2820

acaacgtcac ccaatcttgg gactcgggag aataacgccg accaggttac ccctgtatcc     2880

catatcggtt gtcctaatac gacacaacaa ggcagtcctg tattcgctaa actcttggca     2940

aaaaaccagg ccagtctttg taatacgacg cttaattggc atagccagga cggtgcgggc     3000

agctcctacc tttcccaggg gctcaggtat gaagaagata agaaagaact cgttgtagac     3060

agtcccggat tgtattacgt ttttttggaa ctcaagctct ctccaacctt caccaatacg     3120

ggacataagg tccagggctg ggtgagcctc gtactccagg ctaagccgca agttgacgat     3180

ttcgataatc tcgctcttac agtggagttg tttccctgta gtatggagaa taagctcgtc     3240

gaccggtctt ggagccaact tctgctgctt aaggctggtc accggctcag tgtaggcctc     3300

cgagcgtatt tgcatggggc gcaggacgcc tatcgagact gggagctttc ctaccctaac     3360

acgaccagct ttggactctt cttggtgaaa cctgacaatc cgtgggaata a              3411


<210>  12
<211>  1836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-HC-heavy-full-(mu)GITRL-pCR3 (N297A)

<400>  12
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatccagc agcgcctcta caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgaccgtg tcctggaact ctggcgctct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

acagtgccca gcagctctct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccccga actgctggga ggcccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac gccagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgccccc aagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattcc caactgccat cgagtcctgc atggttaagt ttgaactatc atcctcaaaa     1500

tggcacatga catctcccaa acctcactgt gtgaatacga catctgatgg gaagctgaag     1560

atactgcaga gtggcacata tttaatctac ggccaagtga ttcctgtgga taagaaatac     1620

ataaaagaca atgccccctt cgtagtacag atatataaaa agaatgatgt cctacaaact     1680

ctaatgaatg attttcaaat cttgcctata ggaggggttt atgaactgca tgctggagat     1740

aacatatatc tgaagttcaa ctctaaagac catattcaga aaactaacac atactggggg     1800

atcatcttaa tgcctgatct accattcatc tcttag                               1836


<210>  13
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4-LC-light-full-pCR3 (Flagless)

<400>  13
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggacatt gtgatgaccc agtctcacaa attcatgtcc      120

acatcagtag gagacagggt cagcatcacc tgcaaggcca gtcaggatgt ggatactgct      180

gtagcctggt atcaacaaaa accagggcaa tctcctaaac tactgattta ctgggcatcc      240

acccggcaca ctggagtccc tgatcgcttc acaggcagtg gatctgggac agattatact      300

ctcaccatca gcagtgtgca ggctgaagac ctggcgcgtt attactgtca gcaatattat      360

agtgttcctc cgacgttcgg tggaggcacc aagctgggat ccgaaatcaa gcgtacggtg      420

gccgctccca gcgtgttcat cttcccacct agcgacgagc agctgaagtc cggcacagcc      480

tctgtcgtgt gcctgctgaa caacttctac ccccgcgagg ccaaggtgca gtggaaggtg      540

gacaatgccc tgcagagcgg caacagccag gaaagcgtga ccgagcagga cagcaaggac      600

tccacctaca gcctgagcag caccctgacc ctgagcaagg ccgactacga gaagcacaag      660

gtgtacgcct gcgaagtgac ccaccagggc ctgtctagcc ccgtgaccaa gagcttcaac      720

cggggcgagt gctaa                                                       735


<210>  14
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD95(E09)-Flag-VH-full-scFv-anti-CD19-pCR3 (IgG1)

<400>  14
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccagctg      120

cagctgcagg aatctggccc tggcctcgtg aagcccagcg agacactgag cctgacctgt      180

accgtgtccg gcgccagcat cagcgccaac agctactatg gcgtgtgggt gcgccagagc      240

cctggcaagg gactggaatg ggtgggatct atcgcctacc ggggcaacag caacagcggc      300

agcacctact acaaccccag cctgaagtcc cgggccaccg tgtctgtgga caccagcaag      360

aaccaggtgt ccctgcggct gacctctgtg acagccgccg ataccgccct gtactactgc      420

gccagaaggc agctgctgga cgacggcaca ggatatcagt gggccgcctt cgatgtgtgg      480

ggccagggaa caatggtcac cgtgtcctcc agatcctcta gcgccagcac aaagggcccc      540

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      600

tgcctcgtga aggactactt tcccgagccc gtgacagtgt cctggaactc tggcgccctg      660

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      720

agcgtcgtga ctgtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      780

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      840

cacacctgtc ccccttgtcc tgcccctgaa ctgctgggcg gaccttccgt gttcctgttc      900

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      960

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa     1020

gtgcacaacg ccaagaccaa gcccagagag gaacagtaca acagcaccta ccgggtggtg     1080

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1140

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1200

cgcgaacccc aggtgtacac actgcctccc agcagggacg agctgaccaa gaaccaggtg     1260

tccctgacct gtctcgtgaa aggcttctac ccctccgata tcgccgtgga atgggagagc     1320

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1380

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1440

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1500

agccccggca agctcgagga cattcagatg acgcagtctc catcctccat gtctgtatct     1560

ctgggagaca cagtcagcat cacttgccat gcaagtcagg gcattagcag taatataggg     1620

tggttgcagc agaaaccagg gaaatcattt aagggcctga tctatcatgg aaccaacttg     1680

gaagatggag ttccatcaag gttcagtggc agtggatctg gagcagatta ttctctcacc     1740

atcagcagcc tggaatctga agattttgca gactattact gtgtacagta tgctcagttt     1800

ccgtacacgt tcggaggggg gaccaagctg gagctgaaac gtggtggtgg tggttctggt     1860

ggtggtggtt ctggcggcgg cggctccagt ggtggtggat cccaggttca gctgcagcaa     1920

tctggacctg agctggtgaa gcctggggcc tcagtgaaga tttcctgcaa agcttctggc     1980

tacgcattca gtagctcttg gatggactgg gtgaagcaga ggcctggaca gggtcttgag     2040

tggattggac ggatttatcc tggagatgga gatactaact acaatgggaa gttcaagggc     2100

aaggccacac tgactgcaga caaatcctcc agcacagcct acatgcagct cagcagcctg     2160

acctctgtgg actctgcggt ctatttctgt gcaaggtcca ttactacggt agtagggtgg     2220

tacttcgatg tctggggcgc agggaccacg gtcaccgttt cctcctaa                  2268


<210>  15
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD95-E09-Flag-VH-heavy-full-pCR3 (IgG1)

<400>  15
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccagctg      120

cagctgcagg aatctggccc tggcctcgtg aagcccagcg agacactgag cctgacctgt      180

accgtgtccg gcgccagcat cagcgccaac agctactatg gcgtgtgggt gcgccagagc      240

cctggcaagg gactggaatg ggtgggatct atcgcctacc ggggcaacag caacagcggc      300

agcacctact acaaccccag cctgaagtcc cgggccaccg tgtctgtgga caccagcaag      360

aaccaggtgt ccctgcggct gacctctgtg acagccgccg ataccgccct gtactactgc      420

gccagaaggc agctgctgga cgacggcaca ggatatcagt gggccgcctt cgatgtgtgg      480

ggccagggaa caatggtcac cgtgtcctcc agatcctcta gcgccagcac aaagggcccc      540

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      600

tgcctcgtga aggactactt tcccgagccc gtgacagtgt cctggaactc tggcgccctg      660

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      720

agcgtcgtga ctgtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      780

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      840

cacacctgtc ccccttgtcc tgcccctgaa ctgctgggcg gaccttccgt gttcctgttc      900

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      960

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa     1020

gtgcacaacg ccaagaccaa gcccagagag gaacagtaca acagcaccta ccgggtggtg     1080

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1140

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1200

cgcgaacccc aggtgtacac actgcctccc agcagggacg agctgaccaa gaaccaggtg     1260

tccctgacct gtctcgtgaa aggcttctac ccctccgata tcgccgtgga atgggagagc     1320

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1380

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1440

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1500

agccccggca agtaa                                                      1515


<210>  16
<211>  1602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD95(E09)-Flag-VH-FAB2(1-114)-scFv-anti-CD20-pCR3 (IgG1)

<400>  16
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attgcagctg      120

cagctgcagg aatctggccc tggcctcgtg aagcccagcg agacactgag cctgacctgt      180

accgtgtccg gcgccagcat cagcgccaac agctactatg gcgtgtgggt gcgccagagc      240

cctggcaagg gactggaatg ggtgggatct atcgcctacc ggggcaacag caacagcggc      300

agcacctact acaaccccag cctgaagtcc cgggccaccg tgtctgtgga caccagcaag      360

aaccaggtgt ccctgcggct gacctctgtg acagccgccg ataccgccct gtactactgc      420

gccagaaggc agctgctgga cgacggcaca ggatatcagt gggccgcctt cgatgtgtgg      480

ggccagggaa caatggtcac cgtgtcctcc ggatcctcta gcgccagcac aaagggcccc      540

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      600

tgcctcgtga aggactactt tcccgagccc gtgacagtgt cctggaactc tggcgccctg      660

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      720

agcgtcgtga ctgtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      780

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      840

cacacctgtc ccccttgtcc tgccctcgag caggtacaac tgcagcagcc tggggctgag      900

ctggtgaagc ctggggcctc agtgaagatg tcctgcaagg cttctggcta cacatttacc      960

agttacaata tgcactgggt aaaacagaca cctggtcggg gcctggaatg gattggagct     1020

atttatcccg gaaatggtga tacttcctac aatcagaagt tcaaaggcaa ggccacattg     1080

actgcagaca aatcctccag cacagcctac atgcagctca gcagcctgac atctgaggac     1140

tctgcggtct attactgtgc aagatcgact tactacggcg gtgactggta cttcaatgtc     1200

tggggcgcag ggaccacggt caccgtctct tcaggaggag gcggatccgg cggaggcgga     1260

agcggtggcg gaggctctca aattgttctc tcccagtctc cagcaatcct gtctgcatct     1320

ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catccactgg     1380

ttccagcaga agccaggatc ctcccccaaa ccctggattt atgccacatc caacctggct     1440

tctggagtcc ctgttcgctt cagtggcagt gggtctggga cttcttactc tctcacaatc     1500

agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggac tagtaaccca     1560

cccacgttcg gaggggggac caagctggaa atcaaacgtt aa                        1602


<210>  17
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD95-E09-Flag-VH-heavy-full-scBaff-pCR3 (N297A)

<400>  17
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attgcagctg      120

cagctgcagg aatctggccc tggcctcgtg aagcccagcg agacactgag cctgacctgt      180

accgtgtccg gcgccagcat cagcgccaac agctactatg gcgtgtgggt gcgccagagc      240

cctggcaagg gactggaatg ggtgggatct atcgcctacc ggggcaacag caacagcggc      300

agcacctact acaaccccag cctgaagtcc cgggccaccg tgtctgtgga caccagcaag      360

aaccaggtgt ccctgcggct gacctctgtg acagccgccg ataccgccct gtactactgc      420

gccagaaggc agctgctgga cgacggcaca ggatatcagt gggccgcctt cgatgtgtgg      480

ggccagggaa caatggtcac cgtgtcctcc ggatccagca gcgcctctac aaagggcccc      540

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      600

tgcctcgtga aggactactt tcccgagccc gtgaccgtgt cctggaactc tggcgctctg      660

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      720

agcgtcgtga cagtgcccag cagctctctg ggcacccaga cctacatctg caacgtgaac      780

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      840

cacacctgtc ccccttgtcc tgcccccgaa ctgctgggag gcccttccgt gttcctgttc      900

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      960

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa     1020

gtgcacaacg ccaagaccaa gcctagagag gaacagtacg ccagcaccta ccgggtggtg     1080

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1140

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1200

cgcgaacccc aggtgtacac actgccccca agcagggacg agctgaccaa gaaccaggtg     1260

tccctgacct gtctcgtgaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1320

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1380

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1440

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1500

agccccggca agctcgaggg acccgaggaa actgtgactc aggactgtct ccagctcatt     1560

gccgatagtg aaacccctac catccagaaa ggctcttaca ccttcgtgcc atggctgctg     1620

tcattcaaac ggggatctgc tctggaggag aaggaaaaca aaatcctggt caaggaaacc     1680

ggctacttct tcatctacgg ccaggtcctc tacaccgaca aaacatacgc tatggggcat     1740

ctcattcagc ggaaaaaagt ccacgtgttc ggcgacgaac tctctctcgt gacactgttc     1800

cggtgtattc agaacatgcc cgagactctg cccaataata gctgctactc tgctggcatt     1860

gccaaactgg aggagggcga cgaactccag ctggctattc ctagggaaaa tgcccagatt     1920

agcctggacg gggatgtgac attttttggc gccctgaaac tgctgggagg cggagggagt     1980

ggcgggggag gctctggacc tgaggaaact gtgacccagg attgtctcca gctcattgcc     2040

gatagtgaga ctcctaccat tcagaaggga tcttacacct ttgtgccttg gctgctgtct     2100

ttcaaacggg gctctgctct ggaggaaaag gagaacaaaa ttctggtcaa agagactggc     2160

tacttcttca tctacggcca ggtgctgtac accgacaaaa catacgccat gggccatctc     2220

attcagcgga aaaaagtcca cgtgttcggc gacgaactct ctctcgtgac actgttccgg     2280

tgtatccaga acatgcccga gacactgccc aataatagct gctactctgc cggcattgct     2340

aaactggagg agggggacga actccagctg gctattccta gggaaaatgc ccagatttct     2400

ctcgatgggg atgtgacatt cttcggggcc ctcaaactgc tgggaggcgg cggatctggc     2460

ggaggcggga gtcaattcgc agcaggtcca gaagaaacag tcactcaaga ctgcttgcaa     2520

ctgattgcag acagtgaaac accaactata caaaaaggat cttacacatt tgttccatgg     2580

cttctcagct ttaaaagggg aagtgcccta gaagaaaaag agaataaaat attggtcaaa     2640

gaaactggtt acttttttat atatggtcag gttttatata ctgataagac ctacgccatg     2700

ggacatctaa ttcagaggaa gaaggtccat gtctttgggg atgaattgag tctggtgact     2760

ttgtttcgat gtattcaaaa tatgcctgaa acactaccca ataattcctg ctattcagct     2820

ggcattgcaa aactggaaga aggagatgaa ctccaacttg caataccaag agaaaatgca     2880

caaatatcac tggatggaga tgtcacattt tttggtgcat tgaaactgct gtga           2934


<210>  18
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD95-E09-Flag-VL-light-full-pCR3

<400>  18
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attgcagagc      120

gtgctgaccc agcctcctag cgtgtccgaa gcccctagac agaccgtgac catcagctgc      180

tccggcaaca gcttcaacat cggcagatac cccgtgaact ggtatcagca gctgccaggc      240

aaggccccta aactgctgat ctactataac aacctgcggt tcagcggagt gtccgaccgg      300

ttctctggca gcaagtctgg cacatctgcc agcctggcca tccgggatct gctgtctgag      360

gacgaggccg actactactg cagcacctgg gacgacaccc tgaagggctg ggtgttcggc      420

ggaggcacca aagtgacagt gctgggcgga tccgaaatca agcgtacggt ggccgctccc      480

agcgtgttca tcttcccacc tagcgacgag cagctgaagt ccggcacagc ctctgtcgtg      540

tgcctgctga acaacttcta cccccgcgag gccaaggtgc agtggaaggt ggacaatgcc      600

ctgcagagcg gcaacagcca ggaaagcgtg accgagcagg acagcaagga ctccacctac      660

agcctgagca gcaccctgac cctgagcaag gccgactacg agaagcacaa ggtgtacgcc      720

tgcgaagtga cccaccaggg cctgtctagc cccgtgacca agagcttcaa ccggggcgag      780

tgctaa                                                                 786


<210>  19
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 1

<400>  19

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Leu Gln Gln Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly 
    50                  55                  60                  


Tyr Ser Ile Thr Thr Asn Tyr Asn Trp Asn Trp Ile Arg Gln Phe Pro 
65                  70                  75                  80  


Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Arg Tyr Asp Gly Thr Ser 
                85                  90                  95      


Glu Tyr Thr Pro Ser Leu Lys Asn Arg Val Ser Ile Thr Arg Asp Thr 
            100                 105                 110         


Ser Met Asn Gln Phe Phe Leu Arg Leu Thr Ser Val Thr Pro Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys Glu Phe Glu Phe Thr Arg Asp Lys Pro Val Ala His 
                485                 490                 495     


Val Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln 
            500                 505                 510         


Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln 
        515                 520                 525             


Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu 
    530                 535                 540                 


Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val 
545                 550                 555                 560 


Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala 
                565                 570                 575     


Val Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys 
            580                 585                 590         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        595                 600                 605             


Gly Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe 
    610                 615                 620                 


Arg Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Lys Pro 
                645                 650                 655     


Val Ala His Val Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp 
            660                 665                 670         


Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys 
        675                 680                 685             


Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser 
    690                 695                 700                 


Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr 
705                 710                 715                 720 


His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu 
                725                 730                 735     


Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala 
            740                 745                 750         


Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln 
        755                 760                 765             


Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr 
    770                 775                 780                 


Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
785                 790                 795                 800 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                805                 810                 815     


Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu Gln 
            820                 825                 830         


Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met 
        835                 840                 845             


Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu 
    850                 855                 860                 


Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val 
865                 870                 875                 880 


Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys 
                885                 890                 895     


Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro 
            900                 905                 910         


Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly 
        915                 920                 925             


Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu 
    930                 935                 940                 


Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val 
945                 950                 955                 960 


Ile Ala Leu 
            


<210>  20
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 2

<400>  20

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Leu Gln Gln Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly 
    50                  55                  60                  


Tyr Ser Ile Thr Thr Asn Tyr Asn Trp Asn Trp Ile Arg Gln Phe Pro 
65                  70                  75                  80  


Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Arg Tyr Asp Gly Thr Ser 
                85                  90                  95      


Glu Tyr Thr Pro Ser Leu Lys Asn Arg Val Ser Ile Thr Arg Asp Thr 
            100                 105                 110         


Ser Met Asn Gln Phe Phe Leu Arg Leu Thr Ser Val Thr Pro Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys 
                


<210>  21
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 3

<400>  21

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Leu Gln Gln Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly 
    50                  55                  60                  


Tyr Ser Ile Thr Thr Asn Tyr Asn Trp Asn Trp Ile Arg Gln Phe Pro 
65                  70                  75                  80  


Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Arg Tyr Asp Gly Thr Ser 
                85                  90                  95      


Glu Tyr Thr Pro Ser Leu Lys Asn Arg Val Ser Ile Thr Arg Asp Thr 
            100                 105                 110         


Ser Met Asn Gln Phe Phe Leu Arg Leu Thr Ser Val Thr Pro Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys Glu Phe Gln Val Gln Leu Gln Gln Pro Gly Ala Glu 
                485                 490                 495     


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
            500                 505                 510         


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
        515                 520                 525             


Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
    530                 535                 540                 


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
545                 550                 555                 560 


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
                565                 570                 575     


Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp 
            580                 585                 590         


Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
    610                 615                 620                 


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
625                 630                 635                 640 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp 
                645                 650                 655     


Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
            660                 665                 670         


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser 
        675                 680                 685             


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
    690                 695                 700                 


Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly 
705                 710                 715                 720 


Gly Gly Thr Lys Leu Glu Ile Lys Arg 
                725                 


<210>  22
<211>  957
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 4

<400>  22

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Leu Gln Gln Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly 
    50                  55                  60                  


Tyr Ser Ile Thr Thr Asn Tyr Asn Trp Asn Trp Ile Arg Gln Phe Pro 
65                  70                  75                  80  


Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Arg Tyr Asp Gly Thr Ser 
                85                  90                  95      


Glu Tyr Thr Pro Ser Leu Lys Asn Arg Val Ser Ile Thr Arg Asp Thr 
            100                 105                 110         


Ser Met Asn Gln Phe Phe Leu Arg Leu Thr Ser Val Thr Pro Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys Leu Glu Gly Pro Glu Glu Thr Val Thr Gln Asp Cys 
                485                 490                 495     


Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser 
            500                 505                 510         


Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu 
        515                 520                 525             


Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe 
    530                 535                 540                 


Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His 
545                 550                 555                 560 


Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu 
                565                 570                 575     


Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn 
            580                 585                 590         


Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu 
        595                 600                 605             


Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly 
    610                 615                 620                 


Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu 
                645                 650                 655     


Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr 
            660                 665                 670         


Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu 
        675                 680                 685             


Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile 
    690                 695                 700                 


Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu 
705                 710                 715                 720 


Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val 
                725                 730                 735     


Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn 
            740                 745                 750         


Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu 
        755                 760                 765             


Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp 
    770                 775                 780                 


Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Gly Gly Gly Gly Ser Gly 
785                 790                 795                 800 


Gly Gly Gly Ser Gln Phe Ala Ala Gly Pro Glu Glu Thr Val Thr Gln 
                805                 810                 815     


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
            820                 825                 830         


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
        835                 840                 845             


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
    850                 855                 860                 


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
865                 870                 875                 880 


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
                885                 890                 895     


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
            900                 905                 910         


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
        915                 920                 925             


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
    930                 935                 940                 


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
945                 950                 955         


<210>  23
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 5

<400>  23

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Asn Pro Leu Ser 
        35                  40                  45              


Leu Pro Val Ser Leu Gly Asp Glu Ala Ser Ile Ser Cys Arg Ser Ser 
    50                  55                  60                  


Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Phe Leu Asn Trp Phe Phe 
65                  70                  75                  80  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn 
                85                  90                  95      


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            100                 105                 110         


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
        115                 120                 125             


Tyr Phe Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gly Gly 
    130                 135                 140                 


Thr Thr Leu Glu Ile Lys Gly Ser Glu Ile Lys Arg Thr Val Ala Ala 
145                 150                 155                 160 


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
                165                 170                 175     


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
            180                 185                 190         


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
        195                 200                 205             


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
    210                 215                 220                 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
225                 230                 235                 240 


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
                245                 250                 255     


Phe Asn Arg Gly Glu Cys 
            260         


<210>  24
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 6

<400>  24

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Leu Pro Gly Thr Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser 
                485                 490                 495     


Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            500                 505                 510         


His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met 
        515                 520                 525             


Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe 
    530                 535                 540                 


Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu 
545                 550                 555                 560 


Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys 
                565                 570                 575     


Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val 
            580                 585                 590         


Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe 
        595                 600                 605             


Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala 
    610                 615                 620                 


Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln 
625                 630                 635 


<210>  25
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 7

<400>  25

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Phe Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val 
                485                 490                 495     


Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile 
            500                 505                 510         


Ser Ser Asn Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys 
        515                 520                 525             


Gly Leu Ile Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg 
    530                 535                 540                 


Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser 
545                 550                 555                 560 


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln 
                565                 570                 575     


Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
        595                 600                 605             


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
    610                 615                 620                 


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
625                 630                 635                 640 


Ser Ser Ser Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
                645                 650                 655     


Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn 
            660                 665                 670         


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
        675                 680                 685             


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val 
    690                 695                 700                 


Tyr Phe Cys Ala Arg Ser Ile Thr Thr Val Val Gly Trp Tyr Phe Asp 
705                 710                 715                 720 


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                725                 730         


<210>  26
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 8

<400>  26

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Phe Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
                485                 490                 495     


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            500                 505                 510         


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu 
        515                 520                 525             


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
    530                 535                 540                 


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
545                 550                 555                 560 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
                565                 570                 575     


Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn 
            580                 585                 590         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
    610                 615                 620                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
625                 630                 635                 640 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                645                 650                 655     


Lys Pro Gly Pro Ser Ser Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            660                 665                 670         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        675                 680                 685             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    690                 695                 700                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
705                 710                 715                 720 


Lys Leu Glu Ile Lys Arg 
                725     


<210>  27
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 9

<400>  27

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  28
<211>  907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 10

<400>  28

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Phe Gly Gly Gly Ser Gly Gln Leu Glu Thr Ala Lys Glu Pro 
                485                 490                 495     


Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
            500                 505                 510         


Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
        515                 520                 525             


Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
    530                 535                 540                 


Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
545                 550                 555                 560 


Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
                565                 570                 575     


Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
            580                 585                 590         


Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
        595                 600                 605             


Leu Ala Asn Pro Gln Phe Ile Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Ser Gln Leu Glu Thr Ala Lys Glu Pro 
625                 630                 635                 640 


Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
                645                 650                 655     


Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
            660                 665                 670         


Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
        675                 680                 685             


Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
    690                 695                 700                 


Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
705                 710                 715                 720 


Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
                725                 730                 735     


Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
            740                 745                 750         


Leu Ala Asn Pro Gln Phe Ile Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        755                 760                 765             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Phe Gln Leu Glu Thr Ala 
    770                 775                 780                 


Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
785                 790                 795                 800 


Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
                805                 810                 815     


Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
            820                 825                 830         


Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
        835                 840                 845             


Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
    850                 855                 860                 


Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
865                 870                 875                 880 


Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
                885                 890                 895     


Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
            900                 905         


<210>  29
<211>  1136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 11

<400>  29

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Phe Gly Gly Gly Ser Gly Thr Glu Pro Arg Pro Ala Leu Thr 
                485                 490                 495     


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
            500                 505                 510         


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
        515                 520                 525             


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
    530                 535                 540                 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
545                 550                 555                 560 


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
                565                 570                 575     


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
            580                 585                 590         


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
        595                 600                 605             


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
    610                 615                 620                 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
625                 630                 635                 640 


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
                645                 650                 655     


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
            660                 665                 670         


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
        675                 680                 685             


Asp Asn Pro Trp Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    690                 695                 700                 


Ser Gly Gly Gly Ser Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr 
705                 710                 715                 720 


Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro 
                725                 730                 735     


Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val 
            740                 745                 750         


Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr 
        755                 760                 765             


Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln 
    770                 775                 780                 


Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro 
785                 790                 795                 800 


Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr 
                805                 810                 815     


Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala 
            820                 825                 830         


Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu 
        835                 840                 845             


Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln 
    850                 855                 860                 


Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala 
865                 870                 875                 880 


Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr 
                885                 890                 895     


Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro 
            900                 905                 910         


Trp Glu Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        915                 920                 925             


Gly Gly Ser Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro 
    930                 935                 940                 


Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser 
945                 950                 955                 960 


His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala 
                965                 970                 975     


Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn 
            980                 985                 990         


Trp His Ser Gln Asp Gly Ala Gly  Ser Ser Tyr Leu Ser  Gln Gly Leu 
        995                 1000                 1005             


Arg Tyr  Glu Glu Asp Lys Lys  Glu Leu Val Val Asp  Ser Pro Gly 
    1010                 1015                 1020             


Leu Tyr  Tyr Val Phe Leu Glu  Leu Lys Leu Ser Pro  Thr Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gly His Lys Val Gln  Gly Trp Val Ser Leu  Val Leu Gln 
    1040                 1045                 1050             


Ala Lys  Pro Gln Val Asp Asp  Phe Asp Asn Leu Ala  Leu Thr Val 
    1055                 1060                 1065             


Glu Leu  Phe Pro Cys Ser Met  Glu Asn Lys Leu Val  Asp Arg Ser 
    1070                 1075                 1080             


Trp Ser  Gln Leu Leu Leu Leu  Lys Ala Gly His Arg  Leu Ser Val 
    1085                 1090                 1095             


Gly Leu  Arg Ala Tyr Leu His  Gly Ala Gln Asp Ala  Tyr Arg Asp 
    1100                 1105                 1110             


Trp Glu  Leu Ser Tyr Pro Asn  Thr Thr Ser Phe Gly  Leu Phe Leu 
    1115                 1120                 1125             


Val Lys  Pro Asp Asn Pro Trp  Glu 
    1130                 1135     


<210>  30
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 12

<400>  30

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Phe Pro Thr Ala Ile Glu Ser Cys Met Val Lys Phe Glu Leu 
                485                 490                 495     


Ser Ser Ser Lys Trp His Met Thr Ser Pro Lys Pro His Cys Val Asn 
            500                 505                 510         


Thr Thr Ser Asp Gly Lys Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu 
        515                 520                 525             


Ile Tyr Gly Gln Val Ile Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn 
    530                 535                 540                 


Ala Pro Phe Val Val Gln Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr 
545                 550                 555                 560 


Leu Met Asn Asp Phe Gln Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu 
                565                 570                 575     


His Ala Gly Asp Asn Ile Tyr Leu Lys Phe Asn Ser Lys Asp His Ile 
            580                 585                 590         


Gln Lys Thr Asn Thr Tyr Trp Gly Ile Ile Leu Met Pro Asp Leu Pro 
        595                 600                 605             


Phe Ile Ser 
    610     


<210>  31
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 13

<400>  31

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Ile Val Met 
            20                  25                  30          


Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser 
        35                  40                  45              


Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
            100                 105                 110         


Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
145                 150                 155                 160 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
                165                 170                 175     


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
            180                 185                 190         


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
        195                 200                 205             


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
    210                 215                 220                 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
225                 230                 235                 240 


Arg Gly Glu Cys 
                


<210>  32
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 14

<400>  32

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
    50                  55                  60                  


Ala Ser Ile Ser Ala Asn Ser Tyr Tyr Gly Val Trp Val Arg Gln Ser 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Gly Ser Ile Ala Tyr Arg Gly Asn 
                85                  90                  95      


Ser Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala 
            100                 105                 110         


Thr Val Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Arg Leu Thr 
        115                 120                 125             


Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Arg Gln 
    130                 135                 140                 


Leu Leu Asp Asp Gly Thr Gly Tyr Gln Trp Ala Ala Phe Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Met Val Thr Val Ser Ser Arg Ser Ser Ser Ala Ser 
                165                 170                 175     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            180                 185                 190         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        195                 200                 205             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    210                 215                 220                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                245                 250                 255     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr 
        515                 520                 525             


Cys His Ala Ser Gln Gly Ile Ser Ser Asn Ile Gly Trp Leu Gln Gln 
    530                 535                 540                 


Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu 
545                 550                 555                 560 


Glu Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp 
                565                 570                 575     


Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr 
            580                 585                 590         


Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr Thr Phe Gly Gly Gly Thr 
        595                 600                 605             


Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
625                 630                 635                 640 


Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
                645                 650                 655     


Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser Trp Met Asp Trp Val Lys 
            660                 665                 670         


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly 
        675                 680                 685             


Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu 
    690                 695                 700                 


Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
705                 710                 715                 720 


Thr Ser Val Asp Ser Ala Val Tyr Phe Cys Ala Arg Ser Ile Thr Thr 
                725                 730                 735     


Val Val Gly Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  33
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 15

<400>  33

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
    50                  55                  60                  


Ala Ser Ile Ser Ala Asn Ser Tyr Tyr Gly Val Trp Val Arg Gln Ser 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Gly Ser Ile Ala Tyr Arg Gly Asn 
                85                  90                  95      


Ser Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala 
            100                 105                 110         


Thr Val Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Arg Leu Thr 
        115                 120                 125             


Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Arg Gln 
    130                 135                 140                 


Leu Leu Asp Asp Gly Thr Gly Tyr Gln Trp Ala Ala Phe Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Met Val Thr Val Ser Ser Arg Ser Ser Ser Ala Ser 
                165                 170                 175     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            180                 185                 190         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        195                 200                 205             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    210                 215                 220                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                245                 250                 255     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 


<210>  34
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 16

<400>  34

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
    50                  55                  60                  


Ala Ser Ile Ser Ala Asn Ser Tyr Tyr Gly Val Trp Val Arg Gln Ser 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Gly Ser Ile Ala Tyr Arg Gly Asn 
                85                  90                  95      


Ser Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala 
            100                 105                 110         


Thr Val Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Arg Leu Thr 
        115                 120                 125             


Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Arg Gln 
    130                 135                 140                 


Leu Leu Asp Asp Gly Thr Gly Tyr Gln Trp Ala Ala Phe Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser 
                165                 170                 175     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            180                 185                 190         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        195                 200                 205             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    210                 215                 220                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                245                 250                 255     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Leu Glu Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
    290                 295                 300                 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
305                 310                 315                 320 


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
                325                 330                 335     


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
            340                 345                 350         


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
        355                 360                 365             


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
385                 390                 395                 400 


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln 
            420                 425                 430         


Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
        435                 440                 445             


Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys 
    450                 455                 460                 


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
465                 470                 475                 480 


Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
                485                 490                 495     


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
            500                 505                 510         


Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        515                 520                 525             


Leu Glu Ile Lys Arg 
    530             


<210>  35
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 17

<400>  35

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
    50                  55                  60                  


Ala Ser Ile Ser Ala Asn Ser Tyr Tyr Gly Val Trp Val Arg Gln Ser 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Gly Ser Ile Ala Tyr Arg Gly Asn 
                85                  90                  95      


Ser Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala 
            100                 105                 110         


Thr Val Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Arg Leu Thr 
        115                 120                 125             


Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Arg Gln 
    130                 135                 140                 


Leu Leu Asp Asp Gly Thr Gly Tyr Gln Trp Ala Ala Phe Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser 
                165                 170                 175     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            180                 185                 190         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        195                 200                 205             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    210                 215                 220                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                245                 250                 255     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Gly Pro Glu Glu Thr Val 
            500                 505                 510         


Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile 
        515                 520                 525             


Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg 
    530                 535                 540                 


Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr 
545                 550                 555                 560 


Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr 
                565                 570                 575     


Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp 
            580                 585                 590         


Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu 
        595                 600                 605             


Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu 
    610                 615                 620                 


Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile 
625                 630                 635                 640 


Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Glu Glu Thr Val Thr 
            660                 665                 670         


Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln 
        675                 680                 685             


Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly 
    690                 695                 700                 


Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly 
705                 710                 715                 720 


Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala 
                725                 730                 735     


Met Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu 
            740                 745                 750         


Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr 
        755                 760                 765             


Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu 
    770                 775                 780                 


Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser 
785                 790                 795                 800 


Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Gly Gly 
                805                 810                 815     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Phe Ala Ala Gly Pro Glu Glu 
            820                 825                 830         


Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro 
        835                 840                 845             


Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe 
    850                 855                 860                 


Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys 
865                 870                 875                 880 


Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys 
                885                 890                 895     


Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe 
            900                 905                 910         


Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met 
        915                 920                 925             


Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys 
    930                 935                 940                 


Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala 
945                 950                 955                 960 


Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu 
                965                 970                 975     


Leu 
    


<210>  36
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 18

<400>  36

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
        35                  40                  45              


Ser Glu Ala Pro Arg Gln Thr Val Thr Ile Ser Cys Ser Gly Asn Ser 
    50                  55                  60                  


Phe Asn Ile Gly Arg Tyr Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly 
65                  70                  75                  80  


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Asn Asn Leu Arg Phe Ser Gly 
                85                  90                  95      


Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
            100                 105                 110         


Ala Ile Arg Asp Leu Leu Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser 
        115                 120                 125             


Thr Trp Asp Asp Thr Leu Lys Gly Trp Val Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Val Thr Val Leu Gly Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro 
145                 150                 155                 160 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                165                 170                 175     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            180                 185                 190         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        195                 200                 205             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
225                 230                 235                 240 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                245                 250                 255     


Asn Arg Gly Glu Cys 
            260     


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aCD40 G28.5

<400>  37

Tyr Ser Ile Thr Thr Asn Tyr Asn Trp Asn 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aCD40 G28.5

<400>  38

Tyr Ile Arg Tyr Asp Gly Thr Ser Glu Tyr Thr Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aCD40 G28.5

<400>  39

Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Phe Leu Asn 
1               5                   10                  15  


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aCD40 G28.5

<400>  40

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aCD40 G28.5

<400>  41

Leu Gln Val Thr His Val Pro Tyr Thr 
1               5                   


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aCD95 E09

<400>  42

Ala Ser Ile Ser Ala Asn Ser Tyr Tyr Gly Val 
1               5                   10      


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aCD95 E09

<400>  43

Ser Ile Ala Tyr Arg Gly Asn Ser Asn Ser Gly Ser Thr Tyr Tyr Asn 
1               5                   10                  15      


Pro Ser Leu Lys Ser 
            20      


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aCD95 E09

<400>  44

Arg Gln Leu Leu Asp Asp Gly Thr Gly Tyr Gln Trp Ala Ala Phe Asp 
1               5                   10                  15      


Val 
    


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aCD95 E09

<400>  45

Ser Gly Asn Ser Phe Asn Ile Gly Arg Tyr Pro Val Asn 
1               5                   10              


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aCD95 E09

<400>  46

Tyr Asn Asn Leu Arg Phe Ser 
1               5           


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aCD95 E09

<400>  47

Ser Thr Trp Asp Asp Thr Leu Lys Gly Trp Val 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aDR5 Conatu

<400>  48

Gly Ser Ile Ser Ser Gly Asp Tyr Phe Trp Ser 
1               5                   10      


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aDR5 Conatu

<400>  49

His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aDR5 Conatu

<400>  50

Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aDR5 Conatu

<400>  51

Arg Ala Ser Gln Gly Ile Ser Arg Ser Tyr Leu Ala 
1               5                   10          


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aDR5 Conatu

<400>  52

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aDR5 Conatu

<400>  53

Gln Gln Phe Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aFn14 P4A8

<400>  54

Tyr Thr Phe Thr Asp Tyr Gly Met His 
1               5                   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aFn14 P4A8

<400>  55

Val Ile Ser Thr Tyr Asn Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aFn14 P4A8

<400>  56

Ala Tyr Tyr Gly Asn Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aFn14 P4A8

<400>  57

Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aFn14 P4A8

<400>  58

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aFn14 P4A8

<400>  59

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aTNFR2 C4

<400>  60

Tyr Ser Phe Thr Ser Tyr Asp Ile Asn 
1               5                   


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aTNFR2 C4

<400>  61

Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aTNFR2 C4

<400>  62

Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aTNFR2 C4

<400>  63

Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala 
1               5                   10      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aTNFR2 C4

<400>  64

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aTNFR2 C4

<400>  65

Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aCD20

<400>  66

Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aCD20

<400>  67

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aCD20

<400>  68

Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10          


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aCD20

<400>  69

Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aCD20

<400>  70

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aCD20

<400>  71

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aCD19

<400>  72

Tyr Ala Phe Ser Ser Ser Trp Met Asp 
1               5                   


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aCD19

<400>  73

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aCD19

<400>  74

Ser Ile Thr Thr Val Val Gly Trp Tyr Phe Asp Val 
1               5                   10          


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aCD19

<400>  75

His Ala Ser Gln Gly Ile Ser Ser Asn Ile Gly 
1               5                   10      


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aCD19

<400>  76

His Gly Thr Asn Leu Glu Asp 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aCD19

<400>  77

Val Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aCD70 1F6

<400>  78

Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aCD70 1F6

<400>  79

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aCD70 1F6

<400>  80

Asp Tyr Gly Asp Tyr Gly Met Asp Tyr 
1               5                   


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aCD70 1F6

<400>  81

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met His 
1               5                   10                  15  


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aCD70 1F6

<400>  82

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aCD70 1F6

<400>  83

Gln His Ser Arg Glu Val Pro Trp Thr 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aFn14 PDL192

<400>  84

Phe Thr Phe Ser Ser Tyr Trp Met Ser 
1               5                   


<210>  85
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aFn14 PDL192

<400>  85

Glu Ile Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aFn14 PDL192

<400>  86

Gly Tyr Tyr Ala Asp Ala Met Asp Tyr 
1               5                   


<210>  87
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aFn14 PDL192

<400>  87

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aFn14 PDL192

<400>  88

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aFn14 PDL192

<400>  89

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-H of aCD70 2H5

<400>  90

Phe Thr Phe Ser Ser Tyr Ile Met His 
1               5                   


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-H of aCD70 2H5

<400>  91

Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-H of aCD70 2H5

<400>  92

Asp Thr Asp Gly Tyr Asp Phe Asp Tyr 
1               5                   


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1-L of aCD70 2H5

<400>  93

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2-L of aCD70 2H5

<400>  94

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3-L of aCD70 2H5

<400>  95

Gln Gln Arg Thr Asn Trp Pro Leu Thr 
1               5                   


<210>  96
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-anti-CD20 anchoring domain from protein construct of SEQ ID 
       NO: 21

<400>  96

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  97
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine IL-2 anchoring domain from protein construct of SEQ ID NO:
       24

<400>  97

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  98
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-anti-CD19 anchoring domain from protein construct of SEQ ID 
       NO: 25

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
145                 150                 155                 160 


Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
            180                 185                 190         


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Ser Ile Thr Thr Val Val Gly Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210>  99
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-anti-CD20 anchoring domain from protein construct of SEQ ID 
       NO: 26

<400>  99

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Pro Ser Ser Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  100
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-anti-CD19 anchoring domain from protein construct of SEQ ID 
       NO: 32

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
145                 150                 155                 160 


Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
            180                 185                 190         


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Ser Ile Thr Thr Val Val Gly Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210>  101
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-anti-CD20 anchoring domain from protein construct of SEQ ID 
       NO: 34

<400>  101

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  102
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTNF80(murine) anchoring domain from protein construct of SEQ ID
       NO: 19

<400>  102

Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu Gln 
1               5                   10                  15      


Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met 
            20                  25                  30          


Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu 
        35                  40                  45              


Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val 
    50                  55                  60                  


Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys 
65                  70                  75                  80  


Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro 
                85                  90                  95      


Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly 
            100                 105                 110         


Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu 
        115                 120                 125             


Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val 
    130                 135                 140                 


Ile Ala Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val 
                165                 170                 175     


Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala 
            180                 185                 190         


Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly 
        195                 200                 205             


Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro 
    210                 215                 220                 


Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr 
225                 230                 235                 240 


Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys 
                245                 250                 255     


Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr 
            260                 265                 270         


Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu 
        275                 280                 285             


Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr 
    290                 295                 300                 


Phe Gly Val Ile Ala Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
                325                 330                 335     


His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala 
            340                 345                 350         


Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro 
        355                 360                 365             


Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln 
    370                 375                 380                 


Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala 
385                 390                 395                 400 


Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro 
                405                 410                 415     


Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu 
            420                 425                 430         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu 
        435                 440                 445             


Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly 
    450                 455                 460                 


Gln Val Tyr Phe Gly Val Ile Ala Leu 
465                 470             


<210>  103
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scBaff anchoring domain from protein construct of SEQ ID NO: 22

<400>  103

Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp 
1               5                   10                  15      


Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp 
            20                  25                  30          


Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys 
        35                  40                  45              


Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu 
    50                  55                  60                  


Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys 
65                  70                  75                  80  


Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
                85                  90                  95      


Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
            100                 105                 110         


Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro 
        115                 120                 125             


Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly 
    130                 135                 140                 


Ala Leu Lys Leu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser 
                165                 170                 175     


Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu 
            180                 185                 190         


Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile 
        195                 200                 205             


Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr 
    210                 215                 220                 


Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val 
225                 230                 235                 240 


His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile 
                245                 250                 255     


Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly 
            260                 265                 270         


Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg 
        275                 280                 285             


Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala 
    290                 295                 300                 


Leu Lys Leu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Phe 
305                 310                 315                 320 


Ala Ala Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile 
                325                 330                 335     


Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val 
            340                 345                 350         


Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu 
        355                 360                 365             


Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln 
    370                 375                 380                 


Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg 
385                 390                 395                 400 


Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe 
                405                 410                 415     


Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr 
            420                 425                 430         


Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala 
        435                 440                 445             


Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe 
    450                 455                 460                 


Phe Gly Ala Leu Lys Leu Leu 
465                 470     


<210>  104
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scGITRL anchoring domain from protein construct of SEQ ID NO: 28

<400>  104

Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu 
1               5                   10                  15      


Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys 
            20                  25                  30          


Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile 
        35                  40                  45              


Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe 
    50                  55                  60                  


Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn 
65                  70                  75                  80  


Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly 
                85                  90                  95      


Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn 
            100                 105                 110         


Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu 
145                 150                 155                 160 


Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys 
                165                 170                 175     


Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile 
            180                 185                 190         


Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe 
        195                 200                 205             


Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn 
    210                 215                 220                 


Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly 
225                 230                 235                 240 


Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn 
                245                 250                 255     


Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Gln Phe Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe 
    290                 295                 300                 


Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys 
305                 310                 315                 320 


Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu 
                325                 330                 335     


Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val 
            340                 345                 350         


Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr 
        355                 360                 365             


Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu 
    370                 375                 380                 


His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val 
385                 390                 395                 400 


Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln 
                405                 410                 415     


Phe Ile Ser 
            


<210>  105
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc(murine)41BBL anchoring domain from protein construct of SEQ ID
       NO: 29

<400>  105

Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly 
1               5                   10                  15      


Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile Gly 
            20                  25                  30          


Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu 
        35                  40                  45              


Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser 
    50                  55                  60                  


Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu 
65                  70                  75                  80  


Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val 
                85                  90                  95      


Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys 
            100                 105                 110         


Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp 
        115                 120                 125             


Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met 
    130                 135                 140                 


Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys 
145                 150                 155                 160 


Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala 
                165                 170                 175     


Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser 
            180                 185                 190         


Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu Gly Gly Gly 
        195                 200                 205             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Thr Glu Pro 
    210                 215                 220                 


Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu 
225                 230                 235                 240 


Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn 
                245                 250                 255     


Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn 
            260                 265                 270         


Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly 
        275                 280                 285             


Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys 
    290                 295                 300                 


Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu 
305                 310                 315                 320 


Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly 
                325                 330                 335     


Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp 
            340                 345                 350         


Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys 
        355                 360                 365             


Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His 
    370                 375                 380                 


Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala 
385                 390                 395                 400 


Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu 
                405                 410                 415     


Phe Leu Val Lys Pro Asp Asn Pro Trp Glu Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Thr Glu Pro Arg Pro 
        435                 440                 445             


Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn 
    450                 455                 460                 


Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr 
465                 470                 475                 480 


Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala 
                485                 490                 495     


Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly 
            500                 505                 510         


Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu 
        515                 520                 525             


Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys 
    530                 535                 540                 


Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val 
545                 550                 555                 560 


Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu 
                565                 570                 575     


Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val 
            580                 585                 590         


Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu 
        595                 600                 605             


Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg 
    610                 615                 620                 


Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu 
625                 630                 635                 640 


Val Lys Pro Asp Asn Pro Trp Glu 
                645             


<210>  106
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (murine)GITRL anchoring domain from protein construct of SEQ ID 
       NO: 30

<400>  106

Pro Thr Ala Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser 
1               5                   10                  15      


Lys Trp His Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser 
            20                  25                  30          


Asp Gly Lys Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly 
        35                  40                  45              


Gln Val Ile Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe 
    50                  55                  60                  


Val Val Gln Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn 
65                  70                  75                  80  


Asp Phe Gln Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly 
                85                  90                  95      


Asp Asn Ile Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr 
            100                 105                 110         


Asn Thr Tyr Trp Gly Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
        115                 120                 125             


<210>  107
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 anchoring domain

<400>  107

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Glu His Lys Pro Ser Ser Gln Arg Lys Glu Glu Ser Thr Cys 
            100                 105                 110     


<210>  108
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40(G28.5)-VH(1-114)

<400>  108
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggatatc      120

cagctccagc agtctggccc tggactcgtc aaaccatctc agagcctgtc tctcacctgt      180

tctgtcaccg gatactccat caccaccaac tacaactgga attggattcg gcagtttcct      240

gggaacaaac tcgaatggat gggatacatc cgatacgacg gcactagtga atacacccca      300

tctctcaaaa atcgggtgtc cattacccgg gacacttcta tgaaccagtt ctttctccga      360

ctcacctctg tgacacctga ggataccgcc acatactact gtgctagact ggactactgg      420

gggcagggaa cactggtgac cgtgtcatct ggatcctcta gcgccagcac aaagggcccc      480

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      540

tgcctcgtga aggactactt tcccgagccc gtgacagtgt cctggaactc tggcgccctg      600

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      660

agcgtcgtga ctgtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      720

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      780

cacacctgtc ccccttgtcc tgcctaa                                          807


<210>  109
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40(G28.5)-VH(1-114)-scBaff

<400>  109
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggatatc      120

cagctccagc agtctggccc tggactcgtc aaaccatctc agagcctgtc tctcacctgt      180

tctgtcaccg gatactccat caccaccaac tacaactgga attggattcg gcagtttcct      240

gggaacaaac tcgaatggat gggatacatc cgatacgacg gcactagtga atacacccca      300

tctctcaaaa atcgggtgtc cattacccgg gacacttcta tgaaccagtt ctttctccga      360

ctcacctctg tgacacctga ggataccgcc acatactact gtgctagact ggactactgg      420

gggcagggaa cactggtgac cgtgtcatct ggatcctcta gcgccagcac aaagggcccc      480

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      540

tgcctcgtga aggactactt tcccgagccc gtgacagtgt cctggaactc tggcgccctg      600

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      660

agcgtcgtga ctgtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      720

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      780

cacacctgtc ccccttgtcc tgccctcgag ggacccgagg aaactgtgac tcaggactgt      840

ctccagctca ttgccgatag tgaaacccct accatccaga aaggctctta caccttcgtg      900

ccatggctgc tgtcattcaa acggggatct gctctggagg agaaggaaaa caaaatcctg      960

gtcaaggaaa ccggctactt cttcatctac ggccaggtcc tctacaccga caaaacatac     1020

gctatggggc atctcattca gcggaaaaaa gtccacgtgt tcggcgacga actctctctc     1080

gtgacactgt tccggtgtat tcagaacatg cccgagactc tgcccaataa tagctgctac     1140

tctgctggca ttgccaaact ggaggagggc gacgaactcc agctggctat tcctagggaa     1200

aatgcccaga ttagcctgga cggggatgtg acattttttg gcgccctgaa actgctggga     1260

ggcggaggga gtggcggggg aggctctgga cctgaggaaa ctgtgaccca ggattgtctc     1320

cagctcattg ccgatagtga gactcctacc attcagaagg gatcttacac ctttgtgcct     1380

tggctgctgt ctttcaaacg gggctctgct ctggaggaaa aggagaacaa aattctggtc     1440

aaagagactg gctacttctt catctacggc caggtgctgt acaccgacaa aacatacgcc     1500

atgggccatc tcattcagcg gaaaaaagtc cacgtgttcg gcgacgaact ctctctcgtg     1560

acactgttcc ggtgtatcca gaacatgccc gagacactgc ccaataatag ctgctactct     1620

gccggcattg ctaaactgga ggagggggac gaactccagc tggctattcc tagggaaaat     1680

gcccagattt ctctcgatgg ggatgtgaca ttcttcgggg ccctcaaact gctgggaggc     1740

ggcggatctg gcggaggcgg gagtcaattc gcagcaggtc cagaagaaac agtcactcaa     1800

gactgcttgc aactgattgc agacagtgaa acaccaacta tacaaaaagg atcttacaca     1860

tttgttccat ggcttctcag ctttaaaagg ggaagtgccc tagaagaaaa agagaataaa     1920

atattggtca aagaaactgg ttactttttt atatatggtc aggttttata tactgataag     1980

acctacgcca tgggacatct aattcagagg aagaaggtcc atgtctttgg ggatgaattg     2040

agtctggtga ctttgtttcg atgtattcaa aatatgcctg aaacactacc caataattcc     2100

tgctattcag ctggcattgc aaaactggaa gaaggagatg aactccaact tgcaatacca     2160

agagaaaatg cacaaatatc actggatgga gatgtcacat tttttggtgc attgaaactg     2220

ctgtga                                                                2226


<210>  110
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD95(E09)-VH(1-114)-scBaff

<400>  110
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attgcagctg      120

cagctgcagg aatctggccc tggcctcgtg aagcccagcg agacactgag cctgacctgt      180

accgtgtccg gcgccagcat cagcgccaac agctactatg gcgtgtgggt gcgccagagc      240

cctggcaagg gactggaatg ggtgggatct atcgcctacc ggggcaacag caacagcggc      300

agcacctact acaaccccag cctgaagtcc cgggccaccg tgtctgtgga caccagcaag      360

aaccaggtgt ccctgcggct gacctctgtg acagccgccg ataccgccct gtactactgc      420

gccagaaggc agctgctgga cgacggcaca ggatatcagt gggccgcctt cgatgtgtgg      480

ggccagggaa caatggtcac cgtgtcctcc ggatcctcta gcgccagcac aaagggcccc      540

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      600

tgcctcgtga aggactactt tcccgagccc gtgacagtgt cctggaactc tggcgccctg      660

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      720

agcgtcgtga ctgtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      780

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      840

cacacctgtc ccccttgtcc tgccctcgag ggacccgagg aaactgtgac tcaggactgt      900

ctccagctca ttgccgatag tgaaacccct accatccaga aaggctctta caccttcgtg      960

ccatggctgc tgtcattcaa acggggatct gctctggagg agaaggaaaa caaaatcctg     1020

gtcaaggaaa ccggctactt cttcatctac ggccaggtcc tctacaccga caaaacatac     1080

gctatggggc atctcattca gcggaaaaaa gtccacgtgt tcggcgacga actctctctc     1140

gtgacactgt tccggtgtat tcagaacatg cccgagactc tgcccaataa tagctgctac     1200

tctgctggca ttgccaaact ggaggagggc gacgaactcc agctggctat tcctagggaa     1260

aatgcccaga ttagcctgga cggggatgtg acattttttg gcgccctgaa actgctggga     1320

ggcggaggga gtggcggggg aggctctgga cctgaggaaa ctgtgaccca ggattgtctc     1380

cagctcattg ccgatagtga gactcctacc attcagaagg gatcttacac ctttgtgcct     1440

tggctgctgt ctttcaaacg gggctctgct ctggaggaaa aggagaacaa aattctggtc     1500

aaagagactg gctacttctt catctacggc caggtgctgt acaccgacaa aacatacgcc     1560

atgggccatc tcattcagcg gaaaaaagtc cacgtgttcg gcgacgaact ctctctcgtg     1620

acactgttcc ggtgtatcca gaacatgccc gagacactgc ccaataatag ctgctactct     1680

gccggcattg ctaaactgga ggagggggac gaactccagc tggctattcc tagggaaaat     1740

gcccagattt ctctcgatgg ggatgtgaca ttcttcgggg ccctcaaact gctgggaggc     1800

ggcggatctg gcggaggcgg gagtcaattc gcagcaggtc cagaagaaac agtcactcaa     1860

gactgcttgc aactgattgc agacagtgaa acaccaacta tacaaaaagg atcttacaca     1920

tttgttccat ggcttctcag ctttaaaagg ggaagtgccc tagaagaaaa agagaataaa     1980

atattggtca aagaaactgg ttactttttt atatatggtc aggttttata tactgataag     2040

acctacgcca tgggacatct aattcagagg aagaaggtcc atgtctttgg ggatgaattg     2100

agtctggtga ctttgtttcg atgtattcaa aatatgcctg aaacactacc caataattcc     2160

tgctattcag ctggcattgc aaaactggaa gaaggagatg aactccaact tgcaatacca     2220

agagaaaatg cacaaatatc actggatgga gatgtcacat tttttggtgc attgaaactg     2280

ctgtga                                                                2286


<210>  111
<211>  2169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-TNFR2(C4)-IgG2-VH-scFv:CD20

<400>  111
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatcctcg agtgctagca ccaagggccc atcggtcttc      480

cccctggcgc cctgctccag gagcacctcc gagagcacag cggccctggg ctgcctggtc      540

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgctct gaccagcggc      600

gtgcacacct tcccagctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      660

accgtgccct ccagcaactt cggcacccag acctacacct gcaacgtaga tcacaagccc      720

agcaacacca aggtggacaa gacagttgag cgcaaatgtt gtgtcgagtg cccaccgtgc      780

ccagcaccac ctgtggcagg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccacgaagac      900

cccgaggtcc agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      960

ccacgggagg agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgttgtgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccagcc     1080

cccatcgaga aaaccatctc caaaaccaaa gggcagcccc gagaaccaca ggtgtacacc     1140

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagctc     1320

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa agaattccag     1440

gtacaactgc agcagcctgg ggctgagctg gtgaagcctg gggcctcagt gaagatgtcc     1500

tgcaaggctt ctggctacac atttaccagt tacaatatgc actgggtaaa acagacacct     1560

ggtcggggcc tggaatggat tggagctatt tatcccggaa atggtgatac ttcctacaat     1620

cagaagttca aaggcaaggc cacattgact gcagacaaat cctccagcac agcctacatg     1680

cagctcagca gcctgacatc tgaggactct gcggtctatt actgtgcaag atcgacttac     1740

tacggcggtg actggtactt caatgtctgg ggcgcaggga ccacggtcac cgtctcttca     1800

ggaggaggcg gatccggcgg aggcggaagc ggtggcggag gctctcaaat tgttctctcc     1860

cagtctccag caatcctgtc tgcatctcca ggggagaagg tcacaatgac ttgcagggcc     1920

agctcaagtg taagttacat ccactggttc cagcagaagc caggatcctc ccccaaaccc     1980

tggatttatg ccacatccaa cctggcttct ggagtccctg ttcgcttcag tggcagtggg     2040

tctgggactt cttactctct cacaatcagc agagtggagg ctgaagatgc tgccacttat     2100

tactgccagc agtggactag taacccaccc acgttcggag gggggaccaa gctggaaatc     2160

aaacgttaa                                                             2169


<210>  112
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-TNFR2(C4)-IgG1(N297A)-VH-scFv:CD70(1F6)

<400>  112
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatccagc agcgcctcta caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgaccgtg tcctggaact ctggcgctct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

acagtgccca gcagctctct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccccga actgctggga ggcccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac gccagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgccccc aagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattcc agattcagct cgtccagtcc ggacctgaag tgaaaaaacc tggcgaaacc     1500

gtgaaaattt cctgtaaggc ctctggctac acctttacca actacggcat gaactgggtc     1560

aaacaggctc ctgggaaggg cctgaaatgg atgggatgga tcaacaccta caccggcgaa     1620

ccaacatacg ccgatgcctt taagggacgc tttgccttct ctctggaaac ttccgcctct     1680

actgcttacc tccagatcaa taacctcaaa aacgaggaca ccgccactta cttttgtgct     1740

cgggattacg gggactacgg gatggattac tggggacagg gaacatctgt gaccgtgtct     1800

agcgcttcta caaaggggcc taaactggag gagggcgagt ttagcgaggc tagagtggat     1860

atcgtgctca cacagtctcc cgcttctctg gctgtctcac tgggccagcg agcaacaatc     1920

tcttgtcggg cttccaaatc cgtgtctact agcggctact cttttatgca ctggtaccag     1980

cagaaacctg ggcagcctcc aaaactgctc atctacctgg cttcaaacct cgaatccgga     2040

gtgcctgctc gattttctgg ctctggctcc gggaccgact ttacactgaa cattcatcct     2100

gtcgaggagg aggacgctgc cacatactac tgtcagcatt ctagggaggt gccatggaca     2160

tttggcgggg gaacaaaact ggaaatcaaa cggtaa                               2196


<210>  113
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-TNFR2(C4)-IgG1(N297A)-VH-scFv:CD70(2H5)

<400>  113
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attgcaggtt cagctgctgc agtctggacc tgagctggtg      120

aagcctgggg cttcagtgaa gttgtcctgc aaggcttctg gttatagttt cacaagttac      180

gatattaact gggtgaagca gaggcctgga cagggacttg agtgggttgg atggatttat      240

cctagagatg gtgatactaa gtacaatgag aaattcaagg gcaaggccat attgactgta      300

gacacatcct ccaacacagc gtacatgaac ctccacagcc tgacatctga ggactctgcg      360

gtctatttct gtgcaagact aactgggccc tactggtact tcgatgtctg gggcacaggg      420

accacggtca ccgtctcctc aggatccagc agcgcctcta caaagggccc cagcgtgttc      480

cctctggccc ctagcagcaa gagcacatct ggcggaacag ccgccctggg ctgcctcgtg      540

aaggactact ttcccgagcc cgtgaccgtg tcctggaact ctggcgctct gacaagcggc      600

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actctctgag cagcgtcgtg      660

acagtgccca gcagctctct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgacaagac ccacacctgt      780

cccccttgtc ctgcccccga actgctggga ggcccttccg tgttcctgtt ccccccaaag      840

cccaaggaca ccctgatgat cagccggacc cccgaagtga cctgcgtggt ggtggatgtg      900

tcccacgagg accctgaagt gaagtttaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac gccagcacct accgggtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

gccctgcctg cccccatcga gaaaaccatc agcaaggcca agggccagcc ccgcgaaccc     1140

caggtgtaca cactgccccc aagcagggac gagctgacca agaaccaggt gtccctgacc     1200

tgtctcgtga aaggcttcta ccccagcgat atcgccgtgg aatgggagag caacggccag     1260

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggctc attcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaagt ccctgagcct gagccccggc     1440

aaggaattcc aggtgcagct ggtggaatct ggcggcggag tggtgcagcc tggcagaagc     1500

ctgagactga gctgtgccgc cagcggcttc accttcagca gctacatcat gcactgggtg     1560

cgccaggccc ctggcaaggg actggaatgg gtggccgtga tcagctacga cggccggaac     1620

aagtactacg ccgacagcgt gaagggccgg ttcaccatct cccgggacaa cagcaagaac     1680

accctgtacc tgcagatgaa cagcctgcgg gccgaggaca ccgccgtgta ctactgtgcc     1740

agagacaccg acggctacga cttcgactat tggggccagg gcaccctcgt gaccgtgtct     1800

agcggaggcg gaggatctgg cggaggggga tcaggcgggg gaggctctga aatcgtgctg     1860

acacagagcc ccgccaccct gtcactgtct ccaggcgaaa gagccaccct gagctgcaga     1920

gccagccaga gcgtgtccag ctacctggcc tggtatcagc agaagcccgg acaggccccc     1980

agactgctga tctacgacgc cagcaatcgg gccacaggca tccctgccag attttccggc     2040

tctggcagcg gcaccgactt caccctgaca atcagcagcc tggaacccga ggactttgcc     2100

gtgtattatt gccagcagcg gaccaactgg cccctgacct ttggcggagg caccaaggtg     2160

gaaatcaagg ccagcaccaa gggctaa                                         2187


<210>  114
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-41BB(HBBK4)-IgG1(N297A)-VH-scFv:CD20

<400>  114
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccaggtc      120

cagctgcagc agtctggcgc cgaagttatt aagcctggcg cctccgtgaa gctgagctgt      180

aaagccagcg gctacacctt cagcagctac tggatgcact gggtccgaca ggctccagga      240

caaggcctgg aatggatcgg cgagatcaac cctggcaacg gccacaccaa ctacaacgag      300

aagttcaaga gccgggccac actgaccggc gataccagca caagcaccgt gtacatggaa      360

ctgagcagcc tgagaagcga ggacaccgcc gtgtactact gcgccagatc ctttaccacc      420

gccagagcct ttgcctattg gggccaggga acactggtca ccgtgtccag cagatccagc      480

agcgcctcta caaagggccc cagcgtgttc cctctggccc ctagcagcaa gagcacatct      540

ggcggaacag ccgccctggg ctgcctcgtg aaggactact ttcccgagcc cgtgaccgtg      600

tcctggaact ctggcgctct gacaagcggc gtgcacacct ttccagccgt gctgcagagc      660

agcggcctgt actctctgag cagcgtcgtg acagtgccca gcagctctct gggcacccag      720

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa      780

cccaagagct gcgacaagac ccacacctgt cccccttgtc ctgcccccga actgctggga      840

ggcccttccg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc      900

cccgaagtga cctgcgtggt ggtggatgtg tcccacgagg accctgaagt gaagtttaat      960

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     1020

gccagcacct accgggtggt gtccgtgctg acagtgctgc accaggactg gctgaacggc     1080

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg cccccatcga gaaaaccatc     1140

agcaaggcca agggccagcc ccgcgaaccc caggtgtaca cactgccccc aagcagggac     1200

gagctgacca agaaccaggt gtccctgacc tgtctcgtga aaggcttcta ccccagcgat     1260

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct     1320

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgaccgtgga caagtcccgg     1380

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1440

acccagaagt ccctgagcct gagccccggc aagctcgagc aggtacaact gcagcagcct     1500

ggggctgagc tggtgaagcc tggggcctca gtgaagatgt cctgcaaggc ttctggctac     1560

acatttacca gttacaatat gcactgggta aaacagacac ctggtcgggg cctggaatgg     1620

attggagcta tttatcccgg aaatggtgat acttcctaca atcagaagtt caaaggcaag     1680

gccacattga ctgcagacaa atcctccagc acagcctaca tgcagctcag cagcctgaca     1740

tctgaggact ctgcggtcta ttactgtgca agatcgactt actacggcgg tgactggtac     1800

ttcaatgtct ggggcgcagg gaccacggtc accgtctctt caggaggagg cggatccggc     1860

ggaggcggaa gcggtggcgg aggctctcaa attgttctct cccagtctcc agcaatcctg     1920

tctgcatctc caggggagaa ggtcacaatg acttgcaggg ccagctcaag tgtaagttac     1980

atccactggt tccagcagaa gccaggatcc tcccccaaac cctggattta tgccacatcc     2040

aacctggctt ctggagtccc tgttcgcttc agtggcagtg ggtctgggac ttcttactct     2100

ctcacaatca gcagagtgga ggctgaagat gctgccactt attactgcca gcagtggact     2160

agtaacccac ccacgttcgg aggggggacc aagctggaaa tcaaacgtta a              2211


<210>  115
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-41BB(HBBK4)-VL

<400>  115
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggacatc      120

gtgatgactc agagccccgc cttcctgtct gtgacccctg gcgagaaagt gaccatcacc      180

tgtagagcca gccagaccat cagcgactac ctgcactggt atcagcagaa gcccgatcag      240

gcccctaagc tgctgattaa gtacgcctct cagagcatca gcggcatccc cagcagattt      300

tctggcagcg gctctggcac cgacttcacc tttaccatca gctccctgga agccgaggat      360

gccgccacct actattgtca ggacggccac agcttccctc caacctttgg acagggcaca      420

aagctggaaa tcaagggatc cgaaatcaag cgtacggtgg ccgctcccag cgtgttcatc      480

ttcccaccta gcgacgagca gctgaagtcc ggcacagcct ctgtcgtgtg cctgctgaac      540

aacttctacc cccgcgaggc caaggtgcag tggaaggtgg acaatgccct gcagagcggc      600

aacagccagg aaagcgtgac cgagcaggac agcaaggact ccacctacag cctgagcagc      660

accctgaccc tgagcaaggc cgactacgag aagcacaagg tgtacgcctg cgaagtgacc      720

caccagggcc tgtctagccc cgtgaccaag agcttcaacc ggggcgagtg ctaa            774


<210>  116
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD95(E09)-IgG1(N297A)-VH-scFv:CD20


<220>
<221>  misc_feature
<222>  (1581)..(1581)
<223>  n is a, c, g, or t

<400>  116
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attgcagctg      120

cagctgcagg aatctggccc tggcctcgtg aagcccagcg agacactgag cctgacctgt      180

accgtgtccg gcgccagcat cagcgccaac agctactatg gcgtgtgggt gcgccagagc      240

cctggcaagg gactggaatg ggtgggatct atcgcctacc ggggcaacag caacagcggc      300

agcacctact acaaccccag cctgaagtcc cgggccaccg tgtctgtgga caccagcaag      360

aaccaggtgt ccctgcggct gacctctgtg acagccgccg ataccgccct gtactactgc      420

gccagaaggc agctgctgga cgacggcaca ggatatcagt gggccgcctt cgatgtgtgg      480

ggccagggaa caatggtcac cgtgtcctcc ggatccagca gcgcctctac aaagggcccc      540

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      600

tgcctcgtga aggactactt tcccgagccc gtgaccgtgt cctggaactc tggcgctctg      660

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      720

agcgtcgtga cagtgcccag cagctctctg ggcacccaga cctacatctg caacgtgaac      780

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagagctg cgacaagacc      840

cacacctgtc ccccttgtcc tgcccccgaa ctgctgggag gcccttccgt gttcctgttc      900

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      960

gtggatgtgt cccacgagga ccctgaagtg aagtttaatt ggtacgtgga cggcgtggaa     1020

gtgcacaacg ccaagaccaa gcctagagag gaacagtacg ccagcaccta ccgggtggtg     1080

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg     1140

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     1200

cgcgaacccc aggtgtacac actgccccca agcagggacg agctgaccaa gaaccaggtg     1260

tccctgacct gtctcgtgaa aggcttctac cccagcgata tcgccgtgga atgggagagc     1320

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     1380

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1440

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1500

agccccggca aggaattcca ggtacaactg cagcagcctg gggctgagct ggtgaagcct     1560

ggggcctcag tgaagatgtc ntgcaaggct tctggctaca catttaccag ttacaatatg     1620

cactgggtaa aacagacacc tggtcggggc ctggaatgga ttggagctat ttatcccgga     1680

aatggtgata cttcctacaa tcagaagttc aaaggcaagg ccacattgac tgcagacaaa     1740

tcctccagca cagcctacat gcagctcagc agcctgacat ctgaggactc tgcggtctat     1800

tactgtgcaa gatcgactta ctacggcggt gactggtact tcaatgtctg gggcgcaggg     1860

accacggtca ccgtctcttc aggaggaggc ggatccggcg gaggcggaag cggtggcgga     1920

ggctctcaaa ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag     1980

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tccactggtt ccagcagaag     2040

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct     2100

gttcgcttca gtggcagtgg gtctgggact tcttactctc tcacaatcag cagagtggag     2160

gctgaagatg ctgccactta ttactgccag cagtggacta gtaacccacc cacgttcgga     2220

ggggggacca agctggaaat caaacgttaa                                      2250


<210>  117
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 108

<400>  117

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Leu Gln Gln Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly 
    50                  55                  60                  


Tyr Ser Ile Thr Thr Asn Tyr Asn Trp Asn Trp Ile Arg Gln Phe Pro 
65                  70                  75                  80  


Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Arg Tyr Asp Gly Thr Ser 
                85                  90                  95      


Glu Tyr Thr Pro Ser Leu Lys Asn Arg Val Ser Ile Thr Arg Asp Thr 
            100                 105                 110         


Ser Met Asn Gln Phe Phe Leu Arg Leu Thr Ser Val Thr Pro Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265             


<210>  118
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 109

<400>  118

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Leu Gln Gln Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly 
    50                  55                  60                  


Tyr Ser Ile Thr Thr Asn Tyr Asn Trp Asn Trp Ile Arg Gln Phe Pro 
65                  70                  75                  80  


Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Arg Tyr Asp Gly Thr Ser 
                85                  90                  95      


Glu Tyr Thr Pro Ser Leu Lys Asn Arg Val Ser Ile Thr Arg Asp Thr 
            100                 105                 110         


Ser Met Asn Gln Phe Phe Leu Arg Leu Thr Ser Val Thr Pro Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro 
145                 150                 155                 160 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                165                 170                 175     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            180                 185                 190         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        195                 200                 205             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    210                 215                 220                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
225                 230                 235                 240 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Leu Glu Gly Pro 
            260                 265                 270         


Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu 
        275                 280                 285             


Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu 
    290                 295                 300                 


Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu 
305                 310                 315                 320 


Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr 
                325                 330                 335     


Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His 
            340                 345                 350         


Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln 
        355                 360                 365             


Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile 
    370                 375                 380                 


Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu 
385                 390                 395                 400 


Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu 
                405                 410                 415     


Lys Leu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Glu 
            420                 425                 430         


Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr 
        435                 440                 445             


Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser 
    450                 455                 460                 


Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val 
465                 470                 475                 480 


Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp 
                485                 490                 495     


Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His Val 
            500                 505                 510         


Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn 
        515                 520                 525             


Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala 
    530                 535                 540                 


Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn 
545                 550                 555                 560 


Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys 
                565                 570                 575     


Leu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Phe Ala Ala 
            580                 585                 590         


Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp 
        595                 600                 605             


Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp 
    610                 615                 620                 


Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys 
625                 630                 635                 640 


Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu 
                645                 650                 655     


Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys 
            660                 665                 670         


Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
        675                 680                 685             


Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
    690                 695                 700                 


Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro 
705                 710                 715                 720 


Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly 
                725                 730                 735     


Ala Leu Lys Leu Leu 
            740     


<210>  119
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 110

<400>  119

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
    50                  55                  60                  


Ala Ser Ile Ser Ala Asn Ser Tyr Tyr Gly Val Trp Val Arg Gln Ser 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Gly Ser Ile Ala Tyr Arg Gly Asn 
                85                  90                  95      


Ser Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala 
            100                 105                 110         


Thr Val Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Arg Leu Thr 
        115                 120                 125             


Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Arg Gln 
    130                 135                 140                 


Leu Leu Asp Asp Gly Thr Gly Tyr Gln Trp Ala Ala Phe Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser 
                165                 170                 175     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            180                 185                 190         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        195                 200                 205             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    210                 215                 220                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                245                 250                 255     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Leu Glu Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile 
    290                 295                 300                 


Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val 
305                 310                 315                 320 


Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu 
                325                 330                 335     


Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln 
            340                 345                 350         


Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg 
        355                 360                 365             


Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe 
    370                 375                 380                 


Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr 
385                 390                 395                 400 


Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala 
                405                 410                 415     


Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe 
            420                 425                 430         


Phe Gly Ala Leu Lys Leu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu Ile Ala 
    450                 455                 460                 


Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro 
465                 470                 475                 480 


Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn 
                485                 490                 495     


Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val 
            500                 505                 510         


Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys 
        515                 520                 525             


Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg 
    530                 535                 540                 


Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser 
545                 550                 555                 560 


Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile 
                565                 570                 575     


Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe 
            580                 585                 590         


Gly Ala Leu Lys Leu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gln Phe Ala Ala Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln 
    610                 615                 620                 


Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr 
625                 630                 635                 640 


Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu 
                645                 650                 655     


Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr 
            660                 665                 670         


Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile 
        675                 680                 685             


Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr 
    690                 695                 700                 


Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser 
705                 710                 715                 720 


Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln 
                725                 730                 735     


Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val 
            740                 745                 750         


Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        755                 760     


<210>  120
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 111

<400>  120

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Gln 
465                 470                 475                 480 


Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
                485                 490                 495     


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn 
            500                 505                 510         


Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly 
        515                 520                 525             


Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
    530                 535                 540                 


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
545                 550                 555                 560 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                565                 570                 575     


Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala 
            580                 585                 590         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala 
    610                 615                 620                 


Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala 
625                 630                 635                 640 


Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser 
                645                 650                 655     


Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val 
            660                 665                 670         


Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        675                 680                 685             


Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    690                 695                 700                 


Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
705                 710                 715                 720 


Lys Arg 
        


<210>  121
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 112

<400>  121

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
                485                 490                 495     


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            500                 505                 510         


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
        515                 520                 525             


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
    530                 535                 540                 


Asp Ala Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
545                 550                 555                 560 


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
                565                 570                 575     


Tyr Phe Cys Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly 
            580                 585                 590         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys 
        595                 600                 605             


Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Asp Ile Val Leu Thr 
    610                 615                 620                 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
625                 630                 635                 640 


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met 
                645                 650                 655     


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
            660                 665                 670         


Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
        675                 680                 685             


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu 
    690                 695                 700                 


Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Val Pro Trp Thr 
705                 710                 715                 720 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
                725                 730     


<210>  122
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 113

<400>  122

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Glu Phe Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                485                 490                 495     


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            500                 505                 510         


Ser Ser Tyr Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        515                 520                 525             


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala 
    530                 535                 540                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
545                 550                 555                 560 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                565                 570                 575     


Tyr Tyr Cys Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly 
            580                 585                 590         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    610                 615                 620                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
625                 630                 635                 640 


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                645                 650                 655     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
            660                 665                 670         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        675                 680                 685             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    690                 695                 700                 


Gln Gln Arg Thr Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
705                 710                 715                 720 


Glu Ile Lys Ala Ser Thr Lys Gly 
                725             


<210>  123
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 114

<400>  123

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
        35                  40                  45              


Val Ile Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Gly Asn Gly His Thr 
                85                  90                  95      


Asn Tyr Asn Glu Lys Phe Lys Ser Arg Ala Thr Leu Thr Gly Asp Thr 
            100                 105                 110         


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Phe Thr Thr Ala Arg Ala Phe 
    130                 135                 140                 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Gln Val Gln 
                485                 490                 495     


Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
            500                 505                 510         


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
        515                 520                 525             


Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile 
    530                 535                 540                 


Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys 
545                 550                 555                 560 


Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
                565                 570                 575     


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser 
            580                 585                 590         


Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr 
        595                 600                 605             


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu 
625                 630                 635                 640 


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
                645                 650                 655     


Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro 
            660                 665                 670         


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val 
        675                 680                 685             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
    690                 695                 700                 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr 
705                 710                 715                 720 


Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
                725                 730                 735     


<210>  124
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 115

<400>  124

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser Pro Ala Phe 
        35                  40                  45              


Leu Ser Val Thr Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
    50                  55                  60                  


Gln Thr Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Pro Asp Gln 
65                  70                  75                  80  


Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile 
                85                  90                  95      


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
            100                 105                 110         


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asp 
        115                 120                 125             


Gly His Ser Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
    130                 135                 140                 


Lys Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
145                 150                 155                 160 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                165                 170                 175     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            180                 185                 190         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        195                 200                 205             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    210                 215                 220                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
225                 230                 235                 240 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                245                 250                 255     


Cys 
    


<210>  125
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 116

<400>  125

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
    50                  55                  60                  


Ala Ser Ile Ser Ala Asn Ser Tyr Tyr Gly Val Trp Val Arg Gln Ser 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Gly Ser Ile Ala Tyr Arg Gly Asn 
                85                  90                  95      


Ser Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala 
            100                 105                 110         


Thr Val Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu Arg Leu Thr 
        115                 120                 125             


Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Arg Gln 
    130                 135                 140                 


Leu Leu Asp Asp Gly Thr Gly Tyr Gln Trp Ala Ala Phe Asp Val Trp 
145                 150                 155                 160 


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Ser Ser Ala Ser 
                165                 170                 175     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            180                 185                 190         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        195                 200                 205             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    210                 215                 220                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                245                 250                 255     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Gln Val Gln Leu Gln Gln 
            500                 505                 510         


Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys 
        515                 520                 525             


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
    530                 535                 540                 


Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
545                 550                 555                 560 


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
                565                 570                 575     


Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
            580                 585                 590         


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr 
        595                 600                 605             


Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr 
    610                 615                 620                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
                645                 650                 655     


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
            660                 665                 670         


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
        675                 680                 685             


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    690                 695                 700                 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
705                 710                 715                 720 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
                725                 730                 735     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            740                 745                 


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBBK4 CDR1-H

<400>  126

Tyr Thr Phe Ser Ser Tyr Trp Met His 
1               5                   


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBBK4  CDR2-H

<400>  127

Glu Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBBK4 CDR3-H

<400>  128

Ser Phe Thr Thr Ala Arg Ala Phe Ala Tyr 
1               5                   10  


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBBK4 CDR1-L

<400>  129

Arg Ala Ser Gln Thr Ile Ser Asp Tyr Leu His 
1               5                   10      


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBBK4 CDR2-L

<400>  130

Leu Ala Ser Gln Ser Ile Ser 
1               5           


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBBK4 CDR3-L

<400>  131

Gln Asp Gly His Ser Phe Pro Pro Thr 
1               5                   


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  URELUMAB CDR1-H

<400>  132

Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 
1               5                   


<210>  133
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  URELUMAB  CDR2-H

<400>  133

Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu Ser 
1               5                   10                  15      


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  URELUMAB CDR3-H

<400>  134

Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  URELUMAB CDR1-L

<400>  135

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  URELUMAB CDR2-L

<400>  136

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  137
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  URELUMAB CDR3-L

<400>  137

Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10      


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTOMILUMAB CDR1-H

<400>  138

Tyr Ser Phe Ser Thr Tyr Trp Ile Ser 
1               5                   


<210>  139
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTOMILUMAB  CDR2-H

<400>  139

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTOMILUMAB CDR3-H

<400>  140

Gly Tyr Gly Ile Phe Asp Tyr 
1               5           


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTOMILUMAB CDR1-L

<400>  141

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTOMILUMAB CDR2-L

<400>  142

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTOMILUMAB CDR3-L

<400>  143

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  144
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv:CD70(1F6) anchoring domain from protein construct of SEQ ID 
       NO: 121

<400>  144

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Lys Leu Glu Glu 
        115                 120                 125             


Gly Glu Phe Ser Glu Ala Arg Val Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Val Pro Trp Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Arg 
                245             


<210>  145
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv:CD70(2H5) anchoring domain from protein construct of SEQ ID 
       NO: 122

<400>  145

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 
    210                 215                 220                 


Thr Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Ala Ser Thr Lys Gly 
                245 


<210>  146
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-TRAILR2(Cona)-IgG1(N297A)-VH-scFv:CD70(9G2)

<400>  146
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccaggtg      120

cagctgcagg aatctggccc tggcctcgtg aagcctagcc agaccctgag cctgacctgt      180

accgtgtctg gcggcagcat cagcagcggc gactacttct ggtcctggat cagacagctg      240

cccggcaagg gcctggaatg gatcggccac atccacaaca gcggcaccac ctactacaac      300

cccagcctga agtccagagt gaccatcagc gtggacacca gcaagaagca gttcagcctg      360

cggctgagca gcgtgacagc cgccgataca gccgtgtact actgcgccag agacagaggc      420

ggcgattact actacggcat ggacgtgtgg ggccagggca ccaccgtgac cgtgtctagc      480

agatccagca gcgcctctac aaagggcccc agcgtgttcc ctctggcccc tagcagcaag      540

agcacatctg gcggaacagc cgccctgggc tgcctcgtga aggactactt tcccgagccc      600

gtgaccgtgt cctggaactc tggcgctctg acaagcggcg tgcacacctt tccagccgtg      660

ctgcagagca gcggcctgta ctctctgagc agcgtcgtga cagtgcccag cagctctctg      720

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      780

aaggtggaac ccaagagctg cgacaagacc cacacctgtc ccccttgtcc tgcccccgaa      840

ctgctgggag gcccttccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc      900

agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg      960

aagtttaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     1020

gaacagtacg ccagcaccta ccgggtggtg tccgtgctga cagtgctgca ccaggactgg     1080

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc ccccatcgag     1140

aaaaccatca gcaaggccaa gggccagccc cgcgaacccc aggtgtacac actgccccca     1200

agcagggacg agctgaccaa gaaccaggtg tccctgacct gtctcgtgaa aggcttctac     1260

cccagcgata tcgccgtgga atgggagagc aacggccagc ccgagaacaa ctacaagacc     1320

accccccctg tgctggacag cgacggctca ttcttcctgt acagcaagct gaccgtggac     1380

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1440

aaccactaca cccagaagtc cctgagcccc ggcaagctcg agcaggtgca gctggtggaa     1500

tctggcggcg gactgatgca gcctggcggc tctctgagac tgagctgtgc cgccagcggc     1560

ttcaccttta gcagcagcgc catgagctgg gtgcgccagg ctcctggaaa gggcctggaa     1620

tgggtgtcca gcatctacag cgacagcagc tacacctact acgccgacag cgtgaagtcc     1680

cggttcacca tcagcaccga caacgccaag aacaccctgt acctgcagat gaacagcctg     1740

aagcccgacg acaccgccgt gtactactgt gccggcagca gcgattacga gggcagcttt     1800

gcctcttggg gccagggcac acaagtgacc gtgtcctcca gatctagcac caagggcccc     1860

aagctggaag agggcgagtt cagcgaggcc caattgcaga gcgtcgtgac ccagcctcct     1920

agcctgtctg cctctcctgg aagcagcgtg cggctgacct gtacactgag cagcggcaac     1980

agcgtgggca actacgacat cagctggtat cagcagaagg ccggcagccc ccccagatac     2040

ctgctgtact actacagcga ttccgtgaag caccagggca gcggcgtgcc cagcagattt     2100

tccggaagct ctgacgccag cgccaacgcc ggactgctgc tgatttctgg cctgcagcct     2160

gaggacgagg ccgactacta ctgcagcgcc tacaagagcg gcagccacgt gttcggcgga     2220

ggcaccaaac tgacagtgct gggctaa                                         2247


<210>  147
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-TRAILR2(Cona)-VL

<400>  147
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggagatc      120

gtgctgaccc agagccctgg caccctgtca ctgtctccag gcgagagagc caccctgagc      180

tgtagagcca gccagggcat cagccggtct tacctggcct ggtatcagca gaagcccggc      240

caggctccta gcctgctgat ctacggcgcc agcagcagag ccaccggcat ccccgataga      300

ttttccggca gcggctccgg caccgacttc accctgacaa tcagcagact ggaacccgag      360

gacttcgccg tgtattattg ccagcagttc ggcagcagcc cctggacctt tggccaggga      420

acaaaagtgg gatccgaaat caagcgtacg gtggccgctc ccagcgtgtt catcttccca      480

cctagcgacg agcagctgaa gtccggcaca gcctctgtcg tgtgcctgct gaacaacttc      540

tacccccgcg aggccaaggt gcagtggaag gtggacaatg ccctgcagag cggcaacagc      600

caggaaagcg tgaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      660

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag      720

ggcctgtcta gccccgtgac caagagcttc aaccggggcg agtgctaa                   768


<210>  148
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40(C)-IgG1(N297A)-VH-scFv:PD-L1(Ave)

<400>  148
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccaggtg      120

cagctggttc agtctggcgc cgaagtgaaa aagcctggcg cctctgtgaa ggtgtcctgt      180

acagccagcg gcttcaacat caaggactac tacgtgcact gggtcaagca ggcccctgga      240

caaggactgg aatggatggg cagaatcgac cccgaggacg gcgactctaa gtacgcccct      300

aagttccagg gcaaagccac catgaccgcc gataccagca caagcaccgt gtacatggaa      360

ctgagcagcc tgagaagcga ggacaccgcc gtgtactact gcaccaccag ctactatgtg      420

ggcacctacg gctattgggg ccagggcaca ctggtcaccg tgtccagcag atccagcagc      480

gcctctacaa agggccccag cgtgttccct ctggccccta gcagcaagag cacatctggc      540

ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      600

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      660

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gctctctggg cacccagacc      720

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      780

aagagctgcg acaagaccca cacctgtccc ccttgtcctg cccccgaact gctgggaggc      840

ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc      900

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gtttaattgg      960

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacgcc     1020

agcacctacc gggtggtgtc cgtgctgaca gtgctgcacc aggactggct gaacggcaaa     1080

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgagaa aaccatcagc     1140

aaggccaagg gccagccccg cgaaccccag gtgtacacac tgcccccaag cagggacgag     1200

ctgaccaaga accaggtgtc cctgacctgt ctcgtgaaag gcttctaccc cagcgatatc     1260

gccgtggaat gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg     1320

ctggacagcg acggctcatt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1380

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1440

cagaagtccc tgagcctgag ccccggcaag ctcgaggagg tgcagctgct ggaatctggc     1500

ggaggacttg ttcagcctgg cggctctctg agactgtctt gtgccgccag cggcttcacc     1560

ttcagcagct atatcatgat gtgggtccga caggcccctg gcaaaggcct tgaatgggtg     1620

tccagcatct atcccagcgg cggcatcacc ttttacgccg acacagtgaa gggcagattc     1680

accatcagcc gggacaacag caagaacacc ctgtacctgc agatgaacag cctgagagcc     1740

gaggacaccg ccgtgtacta ctgcgccaga atcaagctgg gcaccgtgac caccgtggat     1800

tattggggac agggcaccct ggtcaccgtg tcctccagat cttctacaaa gggccccaag     1860

ctggaagagg gcgagtttag cgaagcccaa ttgcagagcg ccctgacaca gcctgcatcc     1920

gtgtctggat ctccaggcca gagcatcacc atctcttgta ccggcacaag ctccgatgtc     1980

ggcggctaca attacgtgtc ctggtatcag cagcaccccg gcaaggcccc taagctgatg     2040

atctacgacg tgtccaacag accctccggc gtgtccaata gattcagcgg cagcaagagc     2100

ggcaacaccg ccagcctgac aattagcgga ctgcaggccg aggacgaggc cgattactac     2160

tgtagcagct acaccagctc ctccaccaga gtgtttggca ccggcaccaa agtgaccgtg     2220

ctttaa                                                                2226


<210>  149
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40(C)-VL

<400>  149
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggacatc      120

cagatgacac agagccccag cagcctgtct gccagcgtgg gagatagagt gaccatcacc      180

tgtagcgcca gcagcagcgt gtcctacatg ctgtggttcc agcagaagcc tggcaaggcc      240

cctaagctgc tgatctacag cacctccaat ctggccagcg gcgtgccaag cagattttct      300

ggctctggca gcggcaccga cttcaccctg accatatcta gcctgcagcc agaggacttc      360

gccacctact actgccagca gcggacattc tacccctaca cctttggcgg aggcaccaag      420

gtggaaatca agggatccga aatcaagcgt acggtggccg ctcccagcgt gttcatcttc      480

ccacctagcg acgagcagct gaagtccggc acagcctctg tcgtgtgcct gctgaacaac      540

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca atgccctgca gagcggcaac      600

agccaggaaa gcgtgaccga gcaggacagc aaggactcca cctacagcct gagcagcacc      660

ctgaccctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacccac      720

cagggcctgt ctagccccgt gaccaagagc ttcaaccggg gcgagtgcta a               771


<210>  150
<211>  1578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD40(C)-Fab2-scFv:PD-L1(Ave)

<400>  150
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccaggtg      120

cagctggttc agtctggcgc cgaagtgaaa aagcctggcg cctctgtgaa ggtgtcctgt      180

acagccagcg gcttcaacat caaggactac tacgtgcact gggtcaagca ggcccctgga      240

caaggactgg aatggatggg cagaatcgac cccgaggacg gcgactctaa gtacgcccct      300

aagttccagg gcaaagccac catgaccgcc gataccagca caagcaccgt gtacatggaa      360

ctgagcagcc tgagaagcga ggacaccgcc gtgtactact gcaccaccag ctactatgtg      420

ggcacctacg gctattgggg ccagggcaca ctggtcaccg tgtccagcag atcctctagc      480

gccagcacaa agggccccag cgtgttccct ctggccccta gcagcaagag cacatctggc      540

ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gacagtgtcc      600

tggaactctg gcgccctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      660

ggcctgtact ctctgagcag cgtcgtgact gtgcccagca gcagcctggg cacccagacc      720

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      780

aagagctgcg acaagaccca cacctgtccc ccttgtcctg ccctcgagga ggtgcagctg      840

ctggaatctg gcggaggact tgttcagcct ggcggctctc tgagactgtc ttgtgccgcc      900

agcggcttca ccttcagcag ctatatcatg atgtgggtcc gacaggcccc tggcaaaggc      960

cttgaatggg tgtccagcat ctatcccagc ggcggcatca ccttttacgc cgacacagtg     1020

aagggcagat tcaccatcag ccgggacaac agcaagaaca ccctgtacct gcagatgaac     1080

agcctgagag ccgaggacac cgccgtgtac tactgcgcca gaatcaagct gggcaccgtg     1140

accaccgtgg attattgggg acagggcacc ctggtcaccg tgtcctccag atcttctaca     1200

aagggcccca agctggaaga gggcgagttt agcgaagccc aattgcagag cgccctgaca     1260

cagcctgcat ccgtgtctgg atctccaggc cagagcatca ccatctcttg taccggcaca     1320

agctccgatg tcggcggcta caattacgtg tcctggtatc agcagcaccc cggcaaggcc     1380

cctaagctga tgatctacga cgtgtccaac agaccctccg gcgtgtccaa tagattcagc     1440

ggcagcaaga gcggcaacac cgccagcctg acaattagcg gactgcaggc cgaggacgag     1500

gccgattact actgtagcag ctacaccagc tcctccacca gagtgtttgg caccggcacc     1560

aaagtgaccg tgctttaa                                                   1578


<210>  151
<211>  2229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-41BB(HBBK)-IgG1(N297A)-VH-scFv:PD-L1(Ave)

<400>  151
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccaggtc      120

cagctgcagc agtctggcgc cgaagttatt aagcctggcg cctccgtgaa gctgagctgt      180

aaagccagcg gctacacctt cagcagctac tggatgcact gggtccgaca ggctccagga      240

caaggcctgg aatggatcgg cgagatcaac cctggcaacg gccacaccaa ctacaacgag      300

aagttcaaga gccgggccac actgaccggc gataccagca caagcaccgt gtacatggaa      360

ctgagcagcc tgagaagcga ggacaccgcc gtgtactact gcgccagatc ctttaccacc      420

gccagagcct ttgcctattg gggccaggga acactggtca ccgtgtccag cagatccagc      480

agcgcctcta caaagggccc cagcgtgttc cctctggccc ctagcagcaa gagcacatct      540

ggcggaacag ccgccctggg ctgcctcgtg aaggactact ttcccgagcc cgtgaccgtg      600

tcctggaact ctggcgctct gacaagcggc gtgcacacct ttccagccgt gctgcagagc      660

agcggcctgt actctctgag cagcgtcgtg acagtgccca gcagctctct gggcacccag      720

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa      780

cccaagagct gcgacaagac ccacacctgt cccccttgtc ctgcccccga actgctggga      840

ggcccttccg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc      900

cccgaagtga cctgcgtggt ggtggatgtg tcccacgagg accctgaagt gaagtttaat      960

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     1020

gccagcacct accgggtggt gtccgtgctg acagtgctgc accaggactg gctgaacggc     1080

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg cccccatcga gaaaaccatc     1140

agcaaggcca agggccagcc ccgcgaaccc caggtgtaca cactgccccc aagcagggac     1200

gagctgacca agaaccaggt gtccctgacc tgtctcgtga aaggcttcta ccccagcgat     1260

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct     1320

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgaccgtgga caagtcccgg     1380

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1440

acccagaagt ccctgagcct gagccccggc aagctcgagg aggtgcagct gctggaatct     1500

ggcggaggac ttgttcagcc tggcggctct ctgagactgt cttgtgccgc cagcggcttc     1560

accttcagca gctatatcat gatgtgggtc cgacaggccc ctggcaaagg ccttgaatgg     1620

gtgtccagca tctatcccag cggcggcatc accttttacg ccgacacagt gaagggcaga     1680

ttcaccatca gccgggacaa cagcaagaac accctgtacc tgcagatgaa cagcctgaga     1740

gccgaggaca ccgccgtgta ctactgcgcc agaatcaagc tgggcaccgt gaccaccgtg     1800

gattattggg gacagggcac cctggtcacc gtgtcctcca gatcttctac aaagggcccc     1860

aagctggaag agggcgagtt tagcgaagcc caattgcaga gcgccctgac acagcctgca     1920

tccgtgtctg gatctccagg ccagagcatc accatctctt gtaccggcac aagctccgat     1980

gtcggcggct acaattacgt gtcctggtat cagcagcacc ccggcaaggc ccctaagctg     2040

atgatctacg acgtgtccaa cagaccctcc ggcgtgtcca atagattcag cggcagcaag     2100

agcggcaaca ccgccagcct gacaattagc ggactgcagg ccgaggacga ggccgattac     2160

tactgtagca gctacaccag ctcctccacc agagtgtttg gcaccggcac caaagtgacc     2220

gtgctttaa                                                             2229


<210>  152
<211>  1581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-41BB(HBBK)-Fab2-scFv:PD-L1(Ave)

<400>  152
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccaggtc      120

cagctgcagc agtctggcgc cgaagttatt aagcctggcg cctccgtgaa gctgagctgt      180

aaagccagcg gctacacctt cagcagctac tggatgcact gggtccgaca ggctccagga      240

caaggcctgg aatggatcgg cgagatcaac cctggcaacg gccacaccaa ctacaacgag      300

aagttcaaga gccgggccac actgaccggc gataccagca caagcaccgt gtacatggaa      360

ctgagcagcc tgagaagcga ggacaccgcc gtgtactact gcgccagatc ctttaccacc      420

gccagagcct ttgcctattg gggccaggga acactggtca ccgtgtccag cagatcctct      480

agcgccagca caaagggccc cagcgtgttc cctctggccc ctagcagcaa gagcacatct      540

ggcggaacag ccgccctggg ctgcctcgtg aaggactact ttcccgagcc cgtgacagtg      600

tcctggaact ctggcgccct gacaagcggc gtgcacacct ttccagccgt gctgcagagc      660

agcggcctgt actctctgag cagcgtcgtg actgtgccca gcagcagcct gggcacccag      720

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa      780

cccaagagct gcgacaagac ccacacctgt cccccttgtc ctgccctcga ggaggtgcag      840

ctgctggaat ctggcggagg acttgttcag cctggcggct ctctgagact gtcttgtgcc      900

gccagcggct tcaccttcag cagctatatc atgatgtggg tccgacaggc ccctggcaaa      960

ggccttgaat gggtgtccag catctatccc agcggcggca tcacctttta cgccgacaca     1020

gtgaagggca gattcaccat cagccgggac aacagcaaga acaccctgta cctgcagatg     1080

aacagcctga gagccgagga caccgccgtg tactactgcg ccagaatcaa gctgggcacc     1140

gtgaccaccg tggattattg gggacagggc accctggtca ccgtgtcctc cagatcttct     1200

acaaagggcc ccaagctgga agagggcgag tttagcgaag cccaattgca gagcgccctg     1260

acacagcctg catccgtgtc tggatctcca ggccagagca tcaccatctc ttgtaccggc     1320

acaagctccg atgtcggcgg ctacaattac gtgtcctggt atcagcagca ccccggcaag     1380

gcccctaagc tgatgatcta cgacgtgtcc aacagaccct ccggcgtgtc caatagattc     1440

agcggcagca agagcggcaa caccgccagc ctgacaatta gcggactgca ggccgaggac     1500

gaggccgatt actactgtag cagctacacc agctcctcca ccagagtgtt tggcaccggc     1560

accaaagtga ccgtgcttta a                                               1581


<210>  153
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1(Ave)-IgG2-VH-scFv:41BB(HBBK)

<400>  153
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attcgaggtg      120

cagctgctgg aatctggcgg aggacttgtt cagcctggcg gctctctgag actgtcttgt      180

gccgccagcg gcttcacctt cagcagctat atcatgatgt gggtccgaca ggcccctggc      240

aaaggccttg aatgggtgtc cagcatctat cccagcggcg gcatcacctt ttacgccgac      300

acagtgaagg gcagattcac catcagccgg gacaacagca agaacaccct gtacctgcag      360

atgaacagcc tgagagccga ggacaccgcc gtgtactact gcgccagaat caagctgggc      420

accgtgacca ccgtggatta ttggggacag ggcaccctgg tcaccgtgtc ctccagatcc      480

tcgagtgcta gcaccaaggg cccatcggtc ttccccctgg cgccctgctc caggagcacc      540

tccgagagca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      600

gtgtcgtgga actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctacag      660

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcaa cttcggcacc      720

cagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagacagtt      780

gagcgcaaat gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca      840

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      900

acgtgcgtgg tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg      960

gacggcgtgg aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg     1020

ttccgtgtgg tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac     1080

aagtgcaagg tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc     1140

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1200

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1260

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc catgctggac     1320

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1380

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1440

agcctctccc tgtctccggg taaagaattc caggtccagc tgcagcagtc tggcgccgaa     1500

gttattaagc ctggcgcctc cgtgaagctg agctgtaaag ccagcggcta caccttcagc     1560

agctactgga tgcactgggt ccgacaggct ccaggacaag gcctggaatg gatcggcgag     1620

atcaaccctg gcaacggcca caccaactac aacgagaagt tcaagagccg ggccacactg     1680

accggcgata ccagcacaag caccgtgtac atggaactga gcagcctgag aagcgaggac     1740

accgccgtgt actactgcgc cagatccttt accaccgcca gagcctttgc ctattggggc     1800

cagggaacac tggtcaccgt gtccagcaga tctagcacaa agggccccaa gctggaagag     1860

ggcgagttta gcgaggccca attggacatc gtgatgactc agagccccgc cttcctgtct     1920

gtgacccctg gcgagaaagt gaccatcacc tgtagagcca gccagaccat cagcgactac     1980

ctgcactggt atcagcagaa gcccgatcag gcccctaagc tgctgattaa gtacgcctct     2040

cagagcatca gcggcatccc cagcagattt tctggcagcg gctctggcac cgacttcacc     2100

tttaccatca gctccctgga agccgaggat gccgccacct actattgtca ggacggccac     2160

agcttccctc caacctttgg acagggcaca aagctggaaa tcaagtaa                  2208


<210>  154
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1(Ave)-VL

<400>  154
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attgcagagc      120

gccctgacac agcctgcatc cgtgtctgga tctccaggcc agagcatcac catctcttgt      180

accggcacaa gctccgatgt cggcggctac aattacgtgt cctggtatca gcagcacccc      240

ggcaaggccc ctaagctgat gatctacgac gtgtccaaca gaccctccgg cgtgtccaat      300

agattcagcg gcagcaagag cggcaacacc gccagcctga caattagcgg actgcaggcc      360

gaggacgagg ccgattacta ctgtagcagc tacaccagct cctccaccag agtgtttggc      420

accggcacca aagtgaccgt gcttggatcc gaaatcaagc gtacggtggc cgctcccagc      480

gtgttcatct tcccacctag cgacgagcag ctgaagtccg gcacagcctc tgtcgtgtgc      540

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caatgccctg      600

cagagcggca acagccagga aagcgtgacc gagcaggaca gcaaggactc cacctacagc      660

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      720

gaagtgaccc accagggcct gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc      780

taa                                                                    783


<210>  155
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-muCD27-IgG1(N297A)-VH-scFv:Fn14(18D1)

<400>  155
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attccaggtc      120

cagctgcagc agtctggcgc cgaacttgtg aagcctggca gcagcgtgaa gatcagctgt      180

aaagccagcg gctacacctt caccagctac gacatgcact ggatcaagca gcagcccggc      240

aaaggcctgg aatggatcgg ctggatctac cccggcaacg gcaacaccaa gtacaaccag      300

aagttcaacg gcaaggccac actgaccgcc gacatctcta gcagcacagc ctacatgcag      360

ctgagcagcc tgaccagcga agatagcgcc gtgtacttct gcgccaaatg gggctacaac      420

aacttcgact actggggcca gggcgtgatg gtcaccgtgt ctagcagatc cagcagcgcc      480

tctacaaagg gccccagcgt gttccctctg gcccctagca gcaagagcac atctggcgga      540

acagccgccc tgggctgcct cgtgaaggac tactttcccg agcccgtgac cgtgtcctgg      600

aactctggcg ctctgacaag cggcgtgcac acctttccag ccgtgctgca gagcagcggc      660

ctgtactctc tgagcagcgt cgtgacagtg cccagcagct ctctgggcac ccagacctac      720

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggaacccaag      780

agctgcgaca agacccacac ctgtccccct tgtcctgccc ccgaactgct gggaggccct      840

tccgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      900

gtgacctgcg tggtggtgga tgtgtcccac gaggaccctg aagtgaagtt taattggtac      960

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gtacgccagc     1020

acctaccggg tggtgtccgt gctgacagtg ctgcaccagg actggctgaa cggcaaagag     1080

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag     1140

gccaagggcc agccccgcga accccaggtg tacacactgc ccccaagcag ggacgagctg     1200

accaagaacc aggtgtccct gacctgtctc gtgaaaggct tctaccccag cgatatcgcc     1260

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg     1320

gacagcgacg gctcattctt cctgtacagc aagctgaccg tggacaagtc ccggtggcag     1380

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1440

aagtccctga gcctgagccc cggcaagctc gaggaggtgc agctggtgga atctggcggc     1500

ggactggtgc agcctggcgg atctctgaga ctgagctgtg ccgccagcgg cttcaccttc     1560

agcaactact ggatgagctg ggtgcgccag gcccctggca aaggactgga atgggtgtcc     1620

ggcatcaacc caggcggcac ctctacctac tacgccgaca gcgtgaaggg ccggttcacc     1680

atcagccggg acaacgccaa gaacaccctg tacctgcaga tgaacagcct gaagtccgag     1740

gacaccgccg tgtactactg cgccaagcac ctgggcaact ggggcgagta caattactgg     1800

ggccagggca cacaagtgac cgtgtccagt agatctagca ccaagggccc caagctggaa     1860

gagggcgagt tcagcgaggc ccaattgcag agcgccctga cccagcctcc aagcgtgtca     1920

ggctctcctg gcaagaccgt gaccatcagc tgtgctggca ccggcggaga tgtgggctac     1980

agaaacagcg tgtcctggta tcagcagctg cccggcatgg cccccaaact gctgatctac     2040

gacgtggaca agcgggcctc tggcatcacc gacagattca gcggcagcaa gagcggcgat     2100

accgccagcc tgacaatcag cggagtgcag agcgaggacg aggccgacta ctactgtgcc     2160

agccagagaa gcggaatcgc cgccgtgttt ggcggaggca cacacctgac agtgctgggc     2220

taa                                                                   2223


<210>  156
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-muCD27-VL

<400>  156
atgaacttcg gcttcagcct gatcttcctg gtgctggtgc tgaagggcgt gcagtgcgaa       60

gtgaagctgg tgccccggca attggactac aaggacgacg acgacaaaga attggacatc      120

cagatgacac agagccctgc cagcctgtct gcctctctgg gagagacagt gtccatcgat      180

tgtctggcca gcgagggcat cagcaacgac ctggcttggt atcagcagaa gtccggcaag      240

agccctcagc tgctgatcaa cagcgccagc agactggaag atggcgtgcc cagcagattt      300

tctggctctg gcagcggcac ccggtacagc ctgaagattt ctggcatgca gcccgaggac      360

gaggccgaat acttctgcct gcaaagctac agaagcccct ggacctttgg cggaggcaca      420

aagctggaac tgaagggatc cgaaatcaag cgtacggtgg ccgctcccag cgtgttcatc      480

ttcccaccta gcgacgagca gctgaagtcc ggcacagcct ctgtcgtgtg cctgctgaac      540

aacttctacc cccgcgaggc caaggtgcag tggaaggtgg acaatgccct gcagagcggc      600

aacagccagg aaagcgtgac cgagcaggac agcaaggact ccacctacag cctgagcagc      660

accctgaccc tgagcaaggc cgactacgag aagcacaagg tgtacgcctg cgaagtgacc      720

caccagggcc tgtctagccc cgtgaccaag agcttcaacc ggggcgagtg ctaa            774


<210>  157
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 146

<400>  157

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
    50                  55                  60                  


Gly Ser Ile Ser Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile His Asn Ser Gly Thr 
                85                  90                  95      


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
            100                 105                 110         


Thr Ser Lys Lys Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
        115                 120                 125             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Gly Asp Tyr Tyr 
    130                 135                 140                 


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
145                 150                 155                 160 


Arg Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                165                 170                 175     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            180                 185                 190         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        195                 200                 205             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    210                 215                 220                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
225                 230                 235                 240 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                245                 250                 255     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu 
                485                 490                 495     


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Pro Gly Gly 
            500                 505                 510         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
        515                 520                 525             


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    530                 535                 540                 


Ser Ser Ile Tyr Ser Asp Ser Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
545                 550                 555                 560 


Lys Ser Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu Tyr 
                565                 570                 575     


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
            580                 585                 590         


Ala Gly Ser Ser Asp Tyr Glu Gly Ser Phe Ala Ser Trp Gly Gln Gly 
        595                 600                 605             


Thr Gln Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu 
    610                 615                 620                 


Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Gln Ser Val Val Thr Gln 
625                 630                 635                 640 


Pro Pro Ser Leu Ser Ala Ser Pro Gly Ser Ser Val Arg Leu Thr Cys 
                645                 650                 655     


Thr Leu Ser Ser Gly Asn Ser Val Gly Asn Tyr Asp Ile Ser Trp Tyr 
            660                 665                 670         


Gln Gln Lys Ala Gly Ser Pro Pro Arg Tyr Leu Leu Tyr Tyr Tyr Ser 
        675                 680                 685             


Asp Ser Val Lys His Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Ser Asp Ala Ser Ala Asn Ala Gly Leu Leu Leu Ile Ser Gly Leu 
705                 710                 715                 720 


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Tyr Lys Ser Gly 
                725                 730                 735     


Ser His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            740                 745                 750 


<210>  158
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 147

<400>  158

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
        35                  40                  45              


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
    50                  55                  60                  


Gln Gly Ile Ser Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
65                  70                  75                  80  


Gln Ala Pro Ser Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
                85                  90                  95      


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            100                 105                 110         


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
        115                 120                 125             


Gln Phe Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Gly 
    130                 135                 140                 


Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
145                 150                 155                 160 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                165                 170                 175     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            180                 185                 190         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        195                 200                 205             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    210                 215                 220                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
225                 230                 235                 240 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250                 255 


<210>  159
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 148

<400>  159

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly 
    50                  55                  60                  


Phe Asn Ile Lys Asp Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser 
                85                  90                  95      


Lys Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr 
            100                 105                 110         


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Val Tyr Tyr Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser Ser Ser 
145                 150                 155                 160 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                165                 170                 175     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            180                 185                 190         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        195                 200                 205             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    210                 215                 220                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
225                 230                 235                 240 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                245                 250                 255     


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
385                 390                 395                 400 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Glu Val Gln Leu 
                485                 490                 495     


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            500                 505                 510         


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met Trp 
        515                 520                 525             


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr 
    530                 535                 540                 


Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys Gly Arg Phe 
545                 550                 555                 560 


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                565                 570                 575     


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile Lys 
            580                 585                 590         


Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        595                 600                 605             


Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly 
    610                 615                 620                 


Glu Phe Ser Glu Ala Gln Leu Gln Ser Ala Leu Thr Gln Pro Ala Ser 
625                 630                 635                 640 


Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr 
                645                 650                 655     


Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 
            660                 665                 670         


Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro 
        675                 680                 685             


Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
    690                 695                 700                 


Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
705                 710                 715                 720 


Cys Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val Phe Gly Thr Gly Thr 
                725                 730                 735     


Lys Val Thr Val Leu 
            740     


<210>  160
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 149

<400>  160

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        35                  40                  45              


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
    50                  55                  60                  


Ser Ser Val Ser Tyr Met Leu Trp Phe Gln Gln Lys Pro Gly Lys Ala 
65                  70                  75                  80  


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
                85                  90                  95      


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            100                 105                 110         


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg 
        115                 120                 125             


Thr Phe Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    130                 135                 140                 


Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                165                 170                 175     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            180                 185                 190         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        195                 200                 205             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
    210                 215                 220                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
225                 230                 235                 240 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250                 255     


<210>  161
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 150

<400>  161

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly 
    50                  55                  60                  


Phe Asn Ile Lys Asp Tyr Tyr Val His Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Glu Asp Gly Asp Ser 
                85                  90                  95      


Lys Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Thr 
            100                 105                 110         


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Val Tyr Tyr Cys Thr Thr Ser Tyr Tyr Val Gly Thr Tyr Gly 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser Ser Ser 
145                 150                 155                 160 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                165                 170                 175     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            180                 185                 190         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        195                 200                 205             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    210                 215                 220                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
225                 230                 235                 240 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                245                 250                 255     


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Leu Glu Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
        275                 280                 285             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    290                 295                 300                 


Phe Ser Ser Tyr Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Trp Val Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr 
                325                 330                 335     


Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
            340                 345                 350         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        355                 360                 365             


Val Tyr Tyr Cys Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser Ser Thr 
385                 390                 395                 400 


Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Gln 
                405                 410                 415     


Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser 
            420                 425                 430         


Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn 
        435                 440                 445             


Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 
    450                 455                 460                 


Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser 
465                 470                 475                 480 


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
                485                 490                 495     


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser 
            500                 505                 510         


Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        515                 520                 525 


<210>  162
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 151

<400>  162

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
        35                  40                  45              


Val Ile Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Gly Asn Gly His Thr 
                85                  90                  95      


Asn Tyr Asn Glu Lys Phe Lys Ser Arg Ala Thr Leu Thr Gly Asp Thr 
            100                 105                 110         


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Phe Thr Thr Ala Arg Ala Phe 
    130                 135                 140                 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Glu Val Gln 
                485                 490                 495     


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
    530                 535                 540                 


Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys Gly Arg 
545                 550                 555                 560 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
                565                 570                 575     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile 
            580                 585                 590         


Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu 
        595                 600                 605             


Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu 
    610                 615                 620                 


Gly Glu Phe Ser Glu Ala Gln Leu Gln Ser Ala Leu Thr Gln Pro Ala 
625                 630                 635                 640 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly 
                645                 650                 655     


Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln 
            660                 665                 670         


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg 
        675                 680                 685             


Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
    690                 695                 700                 


Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
705                 710                 715                 720 


Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val Phe Gly Thr Gly 
                725                 730                 735     


Thr Lys Val Thr Val Leu 
            740         


<210>  163
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 152

<400>  163

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
        35                  40                  45              


Val Ile Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Gly Asn Gly His Thr 
                85                  90                  95      


Asn Tyr Asn Glu Lys Phe Lys Ser Arg Ala Thr Leu Thr Gly Asp Thr 
            100                 105                 110         


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Phe Thr Thr Ala Arg Ala Phe 
    130                 135                 140                 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Leu Glu Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Ser Ser Tyr Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe 
                325                 330                 335     


Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            340                 345                 350         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val 
    370                 375                 380                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser Ser 
385                 390                 395                 400 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                405                 410                 415     


Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
            420                 425                 430         


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
        435                 440                 445             


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
    450                 455                 460                 


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
                485                 490                 495     


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
            500                 505                 510         


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        515                 520                 525     


<210>  164
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 153

<400>  164

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    50                  55                  60                  


Phe Thr Phe Ser Ser Tyr Ile Met Met Trp Val Arg Gln Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr 
                85                  90                  95      


Phe Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            100                 105                 110         


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        115                 120                 125             


Thr Ala Val Tyr Tyr Cys Ala Arg Ile Lys Leu Gly Thr Val Thr Thr 
    130                 135                 140                 


Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Arg Ser 
145                 150                 155                 160 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
                165                 170                 175     


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
            180                 185                 190         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        195                 200                 205             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    210                 215                 220                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
225                 230                 235                 240 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
                245                 250                 255     


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Gln Val Gln Leu Gln Gln 
                485                 490                 495     


Ser Gly Ala Glu Val Ile Lys Pro Gly Ala Ser Val Lys Leu Ser Cys 
            500                 505                 510         


Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg 
        515                 520                 525             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Gly 
    530                 535                 540                 


Asn Gly His Thr Asn Tyr Asn Glu Lys Phe Lys Ser Arg Ala Thr Leu 
545                 550                 555                 560 


Thr Gly Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu 
                565                 570                 575     


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Phe Thr Thr 
            580                 585                 590         


Ala Arg Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        595                 600                 605             


Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser 
    610                 615                 620                 


Glu Ala Gln Leu Asp Ile Val Met Thr Gln Ser Pro Ala Phe Leu Ser 
625                 630                 635                 640 


Val Thr Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Thr 
                645                 650                 655     


Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro 
            660                 665                 670         


Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
        675                 680                 685             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
    690                 695                 700                 


Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asp Gly His 
705                 710                 715                 720 


Ser Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                725                 730                 735 


<210>  165
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 154

<400>  165

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 
        35                  40                  45              


Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser 
    50                  55                  60                  


Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
65                  70                  75                  80  


Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser 
                85                  90                  95      


Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
            100                 105                 110         


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
        115                 120                 125             


Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val Phe Gly Thr Gly Thr Lys 
    130                 135                 140                 


Val Thr Val Leu Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
145                 150                 155                 160 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                165                 170                 175     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            180                 185                 190         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        195                 200                 205             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    210                 215                 220                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
225                 230                 235                 240 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                245                 250                 255     


Arg Gly Glu Cys 
            260 


<210>  166
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 155

<400>  166

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Ser Tyr Asp Met His Trp Ile Lys Gln Gln Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Gly Asn Thr 
                85                  90                  95      


Lys Tyr Asn Gln Lys Phe Asn Gly Lys Ala Thr Leu Thr Ala Asp Ile 
            100                 105                 110         


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Lys Trp Gly Tyr Asn Asn Phe Asp Tyr 
    130                 135                 140                 


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Arg Ser Ser Ser Ala 
145                 150                 155                 160 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
                165                 170                 175     


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            180                 185                 190         


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        195                 200                 205             


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    210                 215                 220                 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
225                 230                 235                 240 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                245                 250                 255     


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Glu Val Gln Leu Val 
                485                 490                 495     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            500                 505                 510         


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Trp Met Ser Trp Val 
        515                 520                 525             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Pro 
    530                 535                 540                 


Gly Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
545                 550                 555                 560 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                565                 570                 575     


Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Leu Gly 
            580                 585                 590         


Asn Trp Gly Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        595                 600                 605             


Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe 
    610                 615                 620                 


Ser Glu Ala Gln Leu Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser 
625                 630                 635                 640 


Gly Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Ala Gly Thr Gly Gly 
                645                 650                 655     


Asp Val Gly Tyr Arg Asn Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly 
            660                 665                 670         


Met Ala Pro Lys Leu Leu Ile Tyr Asp Val Asp Lys Arg Ala Ser Gly 
        675                 680                 685             


Ile Thr Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu 
    690                 695                 700                 


Thr Ile Ser Gly Val Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
705                 710                 715                 720 


Ser Gln Arg Ser Gly Ile Ala Ala Val Phe Gly Gly Gly Thr His Leu 
                725                 730                 735     


Thr Val Leu Gly 
            740 


<210>  167
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein construct expressed from SEQ ID NO: 156

<400>  167

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Met Thr Gln Ser Pro Ala Ser 
        35                  40                  45              


Leu Ser Ala Ser Leu Gly Glu Thr Val Ser Ile Asp Cys Leu Ala Ser 
    50                  55                  60                  


Glu Gly Ile Ser Asn Asp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys 
65                  70                  75                  80  


Ser Pro Gln Leu Leu Ile Asn Ser Ala Ser Arg Leu Glu Asp Gly Val 
                85                  90                  95      


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Tyr Ser Leu Lys 
            100                 105                 110         


Ile Ser Gly Met Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Leu Gln 
        115                 120                 125             


Ser Tyr Arg Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
    130                 135                 140                 


Lys Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
145                 150                 155                 160 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                165                 170                 175     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            180                 185                 190         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        195                 200                 205             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    210                 215                 220                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
225                 230                 235                 240 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                245                 250                 255     


Cys 
    


