﻿                         序列表

<110>  珠海泰诺麦博生物技术有限公司
       广州泰诺迪生物科技有限公司

<120>  针对破伤风毒素的全人源单克隆中和抗体及其应用

<150>  2017114867326
<151>  2017-12-29

<150>  201711486693X
<151>  2017-12-29

<150>  2017114829697
<151>  2017-12-29

<150>  201810420730.5
<151>  2018-05-04

<160>  34

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gly Gly Ser Ile Ser Ser Thr Thr 
1               5               

<210>  1
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               

<210>  2
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Val His Tyr Ser Gly Ser Thr 
1               5           

<210>  3
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Ala Arg Asp Lys Tyr Gln Thr Asp Val Ser Asp Ile 
1               5                   10          

<210>  4
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Gln Ser Ile Thr Ser Ser Phe 
1               5           

<210>  5
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Gly Ala Ser 
1           

<210>  6
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Gln Gln Tyr Asp Thr Ser Arg Thr 
1               5               

<210>  7
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Arg Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Val His Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Phe Thr Leu Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Lys Tyr Gln Thr Asp Val Ser Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         
Val Val Thr Val Ser Ser 
        115             

<210>  8
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Ser Ser 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Thr Ser Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys 
            100                 105  

<210>  9
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               

<210>  10
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Val Tyr Pro Gly Asp Ser Asp Thr 
1               5               

<210>  11
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Ala Thr Gln Gln Ser Asn Pro Tyr Asp Ser Gly Ser Tyr Trp Tyr Phe 
1               5                   10                  15      
Asp Ser 
        

<210>  12
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Arg Ile Ser Cys Gln Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Val Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Ile Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Asn Asn Leu Lys Ala Ser Asp Thr Gly Met Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Gln Gln Ser Asn Pro Tyr Asp Ser Gly Ser Tyr Trp Tyr Phe 
            100                 105                 110         
Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  13
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Gln Gly Ile Arg Asn Phe 
1               5       

<210>  14
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Ala Ala Ser 
1           

<210>  15
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Gln Lys Tyr Phe Ser Ala Pro Pro Asp 
1               5                   

<210>  16
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Asp Ile Val Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Phe Ser Ala Pro Pro 
                85                  90                  95      
Asp Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         

<210>  17
<211>  89
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Gly Tyr Thr Phe Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Met Pro 
1               5                   10                  15      
Gly Lys Gly Leu Glu Trp Met Gly Ile Val Tyr Pro Gly Asp Ser Asp 
            20                  25                  30          
Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Ile Thr Ile Ser Ala Asp 
        35                  40                  45              
Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Asn Leu Lys Ala Ser 
    50                  55                  60                  
Asp Thr Gly Met Tyr Tyr Cys Ala Thr Gln Gln Ser Asn Pro Tyr Asp 
65                  70                  75                  80  
Ser Gly Ser Tyr Trp Tyr Phe Asp Ser 
                85                  

<210>  18
<211>  71
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  18
Gln Gly Ile Arg Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
1               5                   10                  15      
Val Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
            20                  25                  30          
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        35                  40                  45              
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys 
    50                  55                  60                  
Tyr Phe Ser Ala Pro Pro Asp 
65                  70   
 
<210>  19
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Gly Gly Pro Phe Thr Gly Ser Tyr 
1               5               

<210>  20
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  20
Val Ser Gln Ser Gly Ser Thr 
1               5           

<210>  21
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Ala Arg Leu Thr Lys His Tyr Ile Asn Ser Ala Tyr 
1               5                   10          

<210>  22
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  22
Gln Val Gln Leu Gln Glu Ser Gly Ala Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Gly Val Ala Gly Gly Pro Phe Thr Gly Ser 
            20                  25                  30          
Tyr Leu Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Val Ser Gln Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Leu Thr Lys His Tyr Ile Asn Ser Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  23
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  23
Gln Ile Ile Gly Ser Trp 
1               5       

<210>  24
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  24
Lys Ala Ser 
1           

<210>  25
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  25
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   

<210>  26
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ile Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ile Ile Gly Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Leu Val Ile 
        35                  40                  45              
Tyr Lys Ala Ser Arg Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Thr Glu Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  27
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  27
Gly Phe Gly Ile Gly Ile Tyr Thr 
1               5               

<210>  28
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  28
Ile Ser Gly Thr Ser Gln Tyr Ile 
1               5               

<210>  29
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  29
Val Ser Gly Ser Ser Leu Asp Tyr 
1               5               

<210>  30
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  30
Gln Asn Ile Gly Thr Asn 
1               5       

<210>  31
<211>  3
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  31
Gly Ala Ser 
1           

<210>  32
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  32
Tyr Gln Asn Tyr Asn Ser Pro Lys Thr 
1               5                   

<210>  33
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Arg Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Val Ser Gly Phe Gly Ile Gly Ile Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Thr Ser Gln Tyr Ile Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Ser Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Ile Ser Ser 
        115 

<210>  34
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  34
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Gly Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Thr Asn 
            20                  25                  30          
Leu Asn Trp Phe Gln Gln Lys Pro Gly Thr Ala Pro Asn Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Thr Phe Thr Leu Thr Ile Asp Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Asn Tyr Asn Ser Pro Lys 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Asp Leu Lys 
            100                 105         
