                         SEQUENCE LISTING

<110>  ϺϸоԺ
       ϺϸƼ޹˾
 
<120>  һ˫򼤻̼弰;

<130>  IEC180209PCT

<150>  201711462081.7
<151>  2017-12-28

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8źĵİ

<400>  1

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser 
            20              


<210>  2
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD137⼤͵İ

<400>  2

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Glu 
                245     


<210>  3
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8İ

<400>  3

Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu Val Met Tyr 
1               5                   10                  15      


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
            20                  25                  30          


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
        35                  40                  45              


Lys 
    


<210>  4
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28Ĥİ

<400>  4

Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  5
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28ڹ̼źŰڽṹİ

<400>  5

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  6
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD137ڹ̼źŰڽṹİ

<400>  6

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  7
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR1İУźģ

<400>  7

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Gln Gln Trp Gly Ala 
            20                  25                  30          


Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr 
        35                  40                  45              


Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Glu Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Gly Gly Tyr Val 
65                  70                  75                  80  


Thr Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Pro Gly Asn Tyr Asp 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Ala 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr 
            260                 265                 270         


Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser 
385         


<210>  8
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR2İУźģ

<400>  8

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Gln Gln Trp Gly Ala 
            20                  25                  30          


Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr 
        35                  40                  45              


Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Glu Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Gly Gly Tyr Val 
65                  70                  75                  80  


Thr Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Pro Gly Asn Tyr Asp 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Ala 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr 
            260                 265                 270         


Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu 
385             


<210>  9
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR3İУźģ

<400>  9

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Gln Gln Trp Gly Ala 
            20                  25                  30          


Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr 
        35                  40                  45              


Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Glu Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Gly Gly Tyr Val 
65                  70                  75                  80  


Thr Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Pro Gly Asn Tyr Asp 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Ala 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr 
            260                 265                 270         


Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
385                 390                 395                 400 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                405                 410                 415     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            420                 425                 


<210>  10
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR4İУźģ

<400>  10

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Gln Gln Trp Gly Ala 
            20                  25                  30          


Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr 
        35                  40                  45              


Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Glu Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Gly Gly Tyr Val 
65                  70                  75                  80  


Thr Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Pro Gly Asn Tyr Asp 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Ala 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr 
            260                 265                 270         


Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
385                 390                 395                 400 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                405                 410                 415     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            420                 425                 


<210>  11
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR1İУźģ

<400>  11

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
                245                 250                 255     


Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
            260                 265                 270         


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
        275                 280                 285             


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
    290                 295                 300                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
305                 310                 315                 320 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                325                 330                 335     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            340                 345                 350         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        355                 360                 


<210>  12
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR2İУźģ

<400>  12

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
                245                 250                 255     


Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
            260                 265                 270         


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
        275                 280                 285             


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
    290                 295                 300                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
305                 310                 315                 320 


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            340                 345                 350         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360                 365 


<210>  13
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR3İУźģ

<400>  13

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
                245                 250                 255     


Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
            260                 265                 270         


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
        275                 280                 285             


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
    290                 295                 300                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
305                 310                 315                 320 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                325                 330                 335     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            340                 345                 350         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
        355                 360                 365             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Gly Gly Cys Glu Leu 
                405     


<210>  14
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  137DCR4İУźģ

<400>  14

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
                245                 250                 255     


Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
            260                 265                 270         


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
        275                 280                 285             


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
    290                 295                 300                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
305                 310                 315                 320 


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            340                 345                 350         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Ser Lys 
        355                 360                 365             


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
    370                 375                 380                 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
385                 390                 395                 400 


Phe Ala Ala Tyr Arg Ser 
                405     


<210>  15
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR1ĺУźģ

<400>  15
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcaact acagcagtgg ggcgcaggac tgttgaagcc ttcggagacc      120

ctgtccctca cctgcgctgt ctatggtggg tccttcagtg gttactactg gagctggata      180

cgccagtccc cagagaaggg gctggagtgg attggggaaa tcaatcatgg tggatacgtc      240

acctacaatc cgtccctcga gagtcgagtc accatatcag tagacacgtc caagaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ctgtatatta ctgtgcgagg      360

gactatggtc cggggaatta tgactggtac ttcgatctct ggggccgtgg caccctggtc      420

actgtctcct caggtggagg cggttcaggc ggaggtggca gcggcggtgg cgggtcggaa      480

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      540

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc      600

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      660

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      720

gattttgcag tttattactg tcagcagcgt agcaactggc ctccggcgct cactttcggc      780

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      840

attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc      900

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      960

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     1020

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1080

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1140

gacttcgcag cctatcgctc ctgataa                                         1167


<210>  16
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR2ĺУźģ

<400>  16
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcaact acagcagtgg ggcgcaggac tgttgaagcc ttcggagacc      120

ctgtccctca cctgcgctgt ctatggtggg tccttcagtg gttactactg gagctggata      180

cgccagtccc cagagaaggg gctggagtgg attggggaaa tcaatcatgg tggatacgtc      240

acctacaatc cgtccctcga gagtcgagtc accatatcag tagacacgtc caagaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ctgtatatta ctgtgcgagg      360

gactatggtc cggggaatta tgactggtac ttcgatctct ggggccgtgg caccctggtc      420

actgtctcct caggtggagg cggttcaggc ggaggtggca gcggcggtgg cgggtcggaa      480

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      540

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc      600

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      660

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      720

gattttgcag tttattactg tcagcagcgt agcaactggc ctccggcgct cactttcggc      780

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      840

attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc      900

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      960

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     1020

tttattattt tctgggtgaa acggggcaga aagaagctcc tgtatatatt caaacaacca     1080

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1140

gaagaagaag gaggatgtga actgtgataa                                      1170


<210>  17
<211>  1293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR3ĺУźģ

<400>  17
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcaact acagcagtgg ggcgcaggac tgttgaagcc ttcggagacc      120

ctgtccctca cctgcgctgt ctatggtggg tccttcagtg gttactactg gagctggata      180

cgccagtccc cagagaaggg gctggagtgg attggggaaa tcaatcatgg tggatacgtc      240

acctacaatc cgtccctcga gagtcgagtc accatatcag tagacacgtc caagaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ctgtatatta ctgtgcgagg      360

gactatggtc cggggaatta tgactggtac ttcgatctct ggggccgtgg caccctggtc      420

actgtctcct caggtggagg cggttcaggc ggaggtggca gcggcggtgg cgggtcggaa      480

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      540

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc      600

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      660

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      720

gattttgcag tttattactg tcagcagcgt agcaactggc ctccggcgct cactttcggc      780

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      840

attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc      900

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      960

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     1020

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1080

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1140

gacttcgcag cctatcgctc caaacggggc agaaagaagc tcctgtatat attcaaacaa     1200

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1260

gaagaagaag aaggaggatg tgaactgtga taa                                  1293


<210>  18
<211>  1293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR4ĺУźģ

<400>  18
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcaact acagcagtgg ggcgcaggac tgttgaagcc ttcggagacc      120

ctgtccctca cctgcgctgt ctatggtggg tccttcagtg gttactactg gagctggata      180

cgccagtccc cagagaaggg gctggagtgg attggggaaa tcaatcatgg tggatacgtc      240

acctacaatc cgtccctcga gagtcgagtc accatatcag tagacacgtc caagaaccag      300

ttctccctga agctgagctc tgtgaccgcc gcggacacgg ctgtatatta ctgtgcgagg      360

gactatggtc cggggaatta tgactggtac ttcgatctct ggggccgtgg caccctggtc      420

actgtctcct caggtggagg cggttcaggc ggaggtggca gcggcggtgg cgggtcggaa      480

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      540

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc      600

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      660

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      720

gattttgcag tttattactg tcagcagcgt agcaactggc ctccggcgct cactttcggc      780

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      840

attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc      900

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      960

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc     1020

tttattattt tctgggtgaa acggggcaga aagaagctcc tgtatatatt caaacaacca     1080

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1140

gaagaagaag gaggatgtga actgaggagt aagaggagca ggctcctgca cagtgactac     1200

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     1260

ccacgcgact tcgcagccta tcgctcctga taa                                  1293


<210>  19
<211>  1098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR1ĺУźģ

<400>  19
caggtgcaac tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat acgccagtcc      120

ccagagaagg ggctggagtg gattggggaa atcaatcatg gtggatacgt cacctacaat      180

ccgtccctcg agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtatatt actgtgcgag ggactatggt      300

ccggggaatt atgactggta cttcgatctc tggggccgtg gcaccctggt cactgtctcc      360

tcaggtggag gcggttcagg cggaggtggc agcggcggtg gcgggtcgga aattgtgttg      420

acacagtctc cagccaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag ctacttagcc tggtaccaac agaaacctgg ccaggctccc      540

aggctcctca tctatgatgc atccaacagg gccactggca tcccagccag gttcagtggc      600

agtgggtctg ggacagactt cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcaactgg cctccggcgc tcactttcgg cggagggacc      720

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      780

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      840

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      900

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      960

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1020

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1080

gcctatcgct cctgataa                                                   1098


<210>  20
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR2ĺУźģ

<400>  20
caggtgcaac tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat acgccagtcc      120

ccagagaagg ggctggagtg gattggggaa atcaatcatg gtggatacgt cacctacaat      180

ccgtccctcg agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtatatt actgtgcgag ggactatggt      300

ccggggaatt atgactggta cttcgatctc tggggccgtg gcaccctggt cactgtctcc      360

tcaggtggag gcggttcagg cggaggtggc agcggcggtg gcgggtcgga aattgtgttg      420

acacagtctc cagccaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag ctacttagcc tggtaccaac agaaacctgg ccaggctccc      540

aggctcctca tctatgatgc atccaacagg gccactggca tcccagccag gttcagtggc      600

agtgggtctg ggacagactt cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcaactgg cctccggcgc tcactttcgg cggagggacc      720

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      780

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      840

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      900

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      960

ttctgggtga aacggggcag aaagaagctc ctgtatatat tcaaacaacc atttatgaga     1020

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1080

ggaggatgtg aactgtgata a                                               1101


<210>  21
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR3ĺУźģ

<400>  21
caggtgcaac tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat acgccagtcc      120

ccagagaagg ggctggagtg gattggggaa atcaatcatg gtggatacgt cacctacaat      180

ccgtccctcg agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtatatt actgtgcgag ggactatggt      300

ccggggaatt atgactggta cttcgatctc tggggccgtg gcaccctggt cactgtctcc      360

tcaggtggag gcggttcagg cggaggtggc agcggcggtg gcgggtcgga aattgtgttg      420

acacagtctc cagccaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag ctacttagcc tggtaccaac agaaacctgg ccaggctccc      540

aggctcctca tctatgatgc atccaacagg gccactggca tcccagccag gttcagtggc      600

agtgggtctg ggacagactt cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcaactgg cctccggcgc tcactttcgg cggagggacc      720

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      780

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      840

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      900

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      960

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1020

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1080

gcctatcgct ccaaacgggg cagaaagaag ctcctgtata tattcaaaca accatttatg     1140

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1200

gaaggaggat gtgaactgtg ataa                                            1224


<210>  22
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  137DCR4ĺУźģ

<400>  22
caggtgcaac tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat acgccagtcc      120

ccagagaagg ggctggagtg gattggggaa atcaatcatg gtggatacgt cacctacaat      180

ccgtccctcg agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtatatt actgtgcgag ggactatggt      300

ccggggaatt atgactggta cttcgatctc tggggccgtg gcaccctggt cactgtctcc      360

tcaggtggag gcggttcagg cggaggtggc agcggcggtg gcgggtcgga aattgtgttg      420

acacagtctc cagccaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag ctacttagcc tggtaccaac agaaacctgg ccaggctccc      540

aggctcctca tctatgatgc atccaacagg gccactggca tcccagccag gttcagtggc      600

agtgggtctg ggacagactt cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcaactgg cctccggcgc tcactttcgg cggagggacc      720

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      780

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      840

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      900

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      960

ttctgggtga aacggggcag aaagaagctc ctgtatatat tcaaacaacc atttatgaga     1020

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1080

ggaggatgtg aactgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1140

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1200

ttcgcagcct atcgctcctg ataa                                            1224


<210>  23
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  meso G1 CARİ

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
                165                 170                 175     


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln 
            180                 185                 190         


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn 
    210                 215                 220                 


Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Tyr Gly Ala Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Asn His Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             


Met Gln Ala Leu Pro Pro Arg 
    450                 455 


<210>  24
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  meso G1 CARĺ

<400>  24
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tacaactgca gcagtctggg cctgagctgg agaagcctgg cgcttcagtg      120

aagatatcct gcaaggcttc tggttactca ttcactggct acaccatgaa ctgggtgaag      180

cagagccatg gaaagagcct tgagtggatt ggacttatta ctccttacaa tggtgcttct      240

agctacaacc agaagttcag gggcaaggcc acattaactg tagacaagtc atccagcaca      300

gcctacatgg acctcctcag tctgacatct gaagactctg cagtctattt ctgtgcaagg      360

gggggttacg acgggagggg ttttgactac tggggccaag ggaccacggt caccgtctcc      420

tcaggtggag gcggttcagg cggaggtggc agcggcggtg gcgggtcgga catcgagctc      480

actcagtctc cagcaatcat gtctgcatct ccaggggaga aggtcaccat gacctgcagt      540

gccagctcaa gtgtaagtta catgcactgg taccagcaga agtcaggcac ctcccccaaa      600

agatggattt atgacacatc caaactggct tctggagtcc caggtcgctt cagtggcagt      660

gggtctggaa actcttactc tctcacaatc agcagcgtgg aggctgaaga tgatgcaact      720

tattactgcc agcagtggag taagcaccct ctcacgtacg gtgctgggac aaagttggaa      780

atcaaattcg tgccggtctt cctgccagcg aagcccacca cgacgccagc gccgcgacca      840

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg      900

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc      960

tgggcgcccc tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac     1020

tgcaaccaca gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     1080

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1140

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1200

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1260

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1320

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctgata a              1371


<210>  25
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3ƵҰ

<400>  25

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  26
<211>  2043
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  meso G2 CARĺ

<400>  26
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagcgagg tgcagctggt ggagtccggg ggaggcctgg tccagcctgg gggatccctg      120

agactctcct gcgcagcctc tggattcgac ctcggtttct acttttacgc ctgttgggtc      180

cgccaggctc cagggaaggg cctggagtgg gtctcatgca tttatactgc tggtagtggt      240

agcacgtact acgcgagctg ggcgaaaggc cgattcacca tctccagaga caattcgaag      300

aacacgctgt atctgcaaat gaacagtctg agagccgagg acacggccgt gtattactgt      360

gcgagatcta ctgctaatac tagaagtact tattatctta acttgtgggg ccaaggcacc      420

ctggtcaccg tctcctcagg cggaggcgga tcaggtggtg gcggatctgg aggtggcgga      480

agcgacatcc agatgaccca gtctccatcc tccctgtctg catctgtggg agacagagtc      540

accatcactt gccaggccag tcagaggatt agtagttact tatcctggta tcagcagaaa      600

ccagggaaag ttcccaagct cctgatctat ggtgcatcca ctctggcatc tggggtcccc      660

tcgcggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag      720

cctgaagatg ttgccactta ctactgtcag agttatgctt attttgatag taataattgg      780

catgctttcg gcggagggac caaggtggag atcaaagagt ccaaatatgg tcccccatgc      840

ccaccatgcc cagcacctcc cgtggccgga ccatcagtct tcctgttccc cccaaaaccc      900

aaggacactc tcatgatctc ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc      960

caggaagacc ccgaggtcca gttcaactgg tacgtggatg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagttccag agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaaggc     1140

ctcccgtcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agagccacag     1200

gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaggctaa ccgtggacaa gagcaggtgg caggagggga atgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacaca cagaagagcc tctccctgtc tctgggtaaa     1500

cccttttggg tgctggtggt ggttggtgga gtcctggctt gctatagctt gctagtaaca     1560

gtggccttta ttattttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     1620

atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca     1680

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     1740

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1800

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1860

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1920

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1980

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2040

cgc                                                                   2043


<210>  27
<211>  2718
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PS328bĺ

<400>  27
ggcgcgcctt aaccctagaa agataatcat attgtgacgt acgttaaaga taatcatgcg       60

taaaattgac gcatgtctag aggtgtggaa agtccccagg ctccccagca ggcagaagta      120

tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag      180

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaaggat ctgcgatcgc      240

tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga      300

ggggtcggca attgaacggg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat      360

gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta      420

gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacagct gaagcttcga      480

ggggctcgca tctctccttc acgcgcccgc cgccctacct gaggccgcca tccacgccgg      540

ttgagtcgcg ttctgccgcc tcccgcctgt ggtgcctcct gaactgcgtc cgccgtctag      600

gtaagtttaa agctcaggtc gagaccgggc ctttgtccgg cgctcccttg gagcctacct      660

agactcagcc ggctctccac gctttgcctg accctgcttg ctcaactcta cgtctttgtt      720

tcgttttctg ttctgcgccg ttacagatcc aagctgtgac cggcgcctac gaattcggat      780

cctgcactag tgctgtcgac cagacatgat aagatacatt gatgagtttg gacaaaccac      840

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt      900

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt      960

tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg     1020

tagcatgcgt caattttacg cagactatct ttctagggtt aaatcgatcc cgctagcccc     1080

gatatcccct taattaagag ggggagacca aagggcgaga cgttaaggcc tcacgtgaca     1140

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     1200

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     1260

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     1320

ctcctgttcc gaccctgccg cttacgggat acctgtccgc ctttctccct tcgggaagcg     1380

tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     1440

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     1500

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     1560

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     1620

actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct     1680

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     1740

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     1800

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     1860

tgccgtctca gaagaactcg tcaagaaggc gatagaaggc gatgcgctgc gaatcgggag     1920

cggcgatacc gtaaagcacg aggaagcggt cagcccattc gccgccaagc tcttcagcaa     1980

tatcacgggt agccaacgct atgtcctgat agcggtccgc cacacccagc cggccacagt     2040

cgatgaatcc agaaaagcgg ccattttcca ccatgatatt cggcaagcag gcatcgccat     2100

gggtcacgac gagatcctcg ccgtcgggca tgctcgcctt gagcctggcg aacagttcgg     2160

ctggcgcgag cccctgatgc tcttcgtcca gatcatcctg atcgacaaga ccggcttcca     2220

tccgagtacg tgctctctcg atgcgatgtt tcgcttggtg gtcgaatggg caggtagccg     2280

gatcaagcgt atgcagccgc cgcattgcat cagccatgat ggatactttc tcggcaggag     2340

caaggtgaga tgacaggaga tcctgccccg gcacttcgcc caatagcagc cagtcccttc     2400

ccgcttcagt gacaacgtcg agtacagctg cgcaaggaac gcccgtcgtg gccagccacg     2460

atagccgcgc tgcctcgtct tgcagttcat tcagggcacc ggacaggtcg gtcttgacaa     2520

aaagaaccgg gcgcccctgc gctgacagcc ggaacacggc ggcatcagag cagccgattg     2580

tctgttgtgc ccagtcatag ccgaatagcc tctccaccca agcggccgga gaacctgcgt     2640

gcaatccatc ttgttcaatc ataatattat tgaagcattt atcagggttc gtctcgtccc     2700

ggtctcctcc catgcatg                                                   2718


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD137-Fļ

<400>  28
cgagtcacca tatcagta                                                     18


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD137-Rļ

<400>  29
cgaagtacca gtcataattc                                                   20


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ̽Taqmanеļ

<400>  30
cctcgcacag taatatacag ccgt                                              24


<210>  31
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28⼤͵İ

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Glu 
            


<210>  32
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28DCR1İУźģ

<400>  32

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn 
65                  70                  75                  80  


Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp 
        115                 120                 125             


Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys 
        195                 200                 205             


Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        275                 280                 285             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    290                 295                 300                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            340                 345                 350         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        355                 360                 365             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380                 


<210>  33
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28DCR2İУźģ

<400>  33

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn 
65                  70                  75                  80  


Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp 
        115                 120                 125             


Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys 
        195                 200                 205             


Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        275                 280                 285             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    290                 295                 300                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu 
385 


<210>  34
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28DCR3İУźģ

<400>  34

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn 
65                  70                  75                  80  


Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp 
        115                 120                 125             


Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys 
        195                 200                 205             


Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        275                 280                 285             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    290                 295                 300                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            340                 345                 350         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        355                 360                 365             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380                 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
385                 390                 395                 400 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
                405                 410                 415     


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            420                 425     


<210>  35
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28DCR4İУźģ

<400>  35

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Cys Ile Tyr Pro Gly Asn Val Asn 
65                  70                  75                  80  


Thr Asn Tyr Asn Glu Lys Phe Lys Asp Arg Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Thr Arg Ser His Tyr Gly Leu Asp Trp 
        115                 120                 125             


Asn Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys 
        195                 200                 205             


Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        275                 280                 285             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    290                 295                 300                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
385                 390                 395                 400 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                405                 410                 415     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            420                 425     


<210>  36
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28DCR1İУźģ

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu 
                245                 250                 255     


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
            260                 265                 270         


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
        275                 280                 285             


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    290                 295                 300                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
305                 310                 315                 320 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                325                 330                 335     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            340                 345                 350         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        355                 360     


<210>  37
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28DCR2İУźģ

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu 
                245                 250                 255     


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
            260                 265                 270         


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
        275                 280                 285             


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    290                 295                 300                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360         


<210>  38
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   28DCR3İУźģ

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu 
                245                 250                 255     


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
            260                 265                 270         


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
        275                 280                 285             


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    290                 295                 300                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
305                 310                 315                 320 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                325                 330                 335     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            340                 345                 350         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        355                 360                 365             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    370                 375                 380                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
385                 390                 395                 400 


Cys Glu Leu 
            


<210>  39
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28DCR4İУźģ

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala 
145                 150                 155                 160 


Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Glu 
                245                 250                 255     


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
            260                 265                 270         


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
        275                 280                 285             


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    290                 295                 300                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Ser Lys Arg Ser Arg 
        355                 360                 365             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    370                 375                 380                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
385                 390                 395                 400 


Tyr Arg Ser 
            


<210>  40
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR1ĺУźģ

<400>  40
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca      120

gtgaaggtct cctgcaaggc ttctggatac accttcacca gctactatat acactgggtg      180

cgacaggccc ctggacaagg gcttgagtgg attggatgta tttatcctgg aaatgtcaat      240

actaactata atgagaagtt caaggacagg gccaccctga ccgtagacac gtccatcagc      300

acagcctaca tggagctgag caggctgaga tctgacgaca cggccgtgta tttctgtaca      360

agatcacact acggcctcga ctggaacttc gatgtctggg gccaagggac cacggtcacc      420

gtctcctcag gtggaggcgg ttcaggcgga ggtggcagcg gcggtggcgg gtcggacatc      480

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      540

tgccatgcca gtcaaaacat ttatgtttgg ttaaactggt atcagcagaa accagggaaa      600

gcccctaagc tcctgatcta taaggcttcc aacctgcaca caggggtccc atcaaggttc      660

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      720

tttgcaactt actactgtca acagggtcaa acttatccgt acacgttcgg cggagggacc      780

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      840

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      900

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1080

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1140

gcctatcgct cctgataa                                                   1158


<210>  41
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR2ĺУźģ

<400>  41
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca      120

gtgaaggtct cctgcaaggc ttctggatac accttcacca gctactatat acactgggtg      180

cgacaggccc ctggacaagg gcttgagtgg attggatgta tttatcctgg aaatgtcaat      240

actaactata atgagaagtt caaggacagg gccaccctga ccgtagacac gtccatcagc      300

acagcctaca tggagctgag caggctgaga tctgacgaca cggccgtgta tttctgtaca      360

agatcacact acggcctcga ctggaacttc gatgtctggg gccaagggac cacggtcacc      420

gtctcctcag gtggaggcgg ttcaggcgga ggtggcagcg gcggtggcgg gtcggacatc      480

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      540

tgccatgcca gtcaaaacat ttatgtttgg ttaaactggt atcagcagaa accagggaaa      600

gcccctaagc tcctgatcta taaggcttcc aacctgcaca caggggtccc atcaaggttc      660

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      720

tttgcaactt actactgtca acagggtcaa acttatccgt acacgttcgg cggagggacc      780

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      840

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      900

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga aacggggcag aaagaagctc ctgtatatat tcaaacaacc atttatgaga     1080

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1140

ggaggatgtg aactgtgata a                                               1161


<210>  42
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR3ĺУźģ

<400>  42
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca      120

gtgaaggtct cctgcaaggc ttctggatac accttcacca gctactatat acactgggtg      180

cgacaggccc ctggacaagg gcttgagtgg attggatgta tttatcctgg aaatgtcaat      240

actaactata atgagaagtt caaggacagg gccaccctga ccgtagacac gtccatcagc      300

acagcctaca tggagctgag caggctgaga tctgacgaca cggccgtgta tttctgtaca      360

agatcacact acggcctcga ctggaacttc gatgtctggg gccaagggac cacggtcacc      420

gtctcctcag gtggaggcgg ttcaggcgga ggtggcagcg gcggtggcgg gtcggacatc      480

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      540

tgccatgcca gtcaaaacat ttatgtttgg ttaaactggt atcagcagaa accagggaaa      600

gcccctaagc tcctgatcta taaggcttcc aacctgcaca caggggtccc atcaaggttc      660

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      720

tttgcaactt actactgtca acagggtcaa acttatccgt acacgttcgg cggagggacc      780

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      840

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      900

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1080

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1140

gcctatcgct ccaaacgggg cagaaagaag ctcctgtata tattcaaaca accatttatg     1200

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1260

gaaggaggat gtgaactgtg ataa                                            1284


<210>  43
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR4ĺУźģ

<400>  43
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcac aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca      120

gtgaaggtct cctgcaaggc ttctggatac accttcacca gctactatat acactgggtg      180

cgacaggccc ctggacaagg gcttgagtgg attggatgta tttatcctgg aaatgtcaat      240

actaactata atgagaagtt caaggacagg gccaccctga ccgtagacac gtccatcagc      300

acagcctaca tggagctgag caggctgaga tctgacgaca cggccgtgta tttctgtaca      360

agatcacact acggcctcga ctggaacttc gatgtctggg gccaagggac cacggtcacc      420

gtctcctcag gtggaggcgg ttcaggcgga ggtggcagcg gcggtggcgg gtcggacatc      480

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      540

tgccatgcca gtcaaaacat ttatgtttgg ttaaactggt atcagcagaa accagggaaa      600

gcccctaagc tcctgatcta taaggcttcc aacctgcaca caggggtccc atcaaggttc      660

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      720

tttgcaactt actactgtca acagggtcaa acttatccgt acacgttcgg cggagggacc      780

aaggtggaga tcaaagagtc caaatatggt cccccatgcc caccatgccc aattgaagtt      840

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      900

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga aacggggcag aaagaagctc ctgtatatat tcaaacaacc atttatgaga     1080

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1140

ggaggatgtg aactgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1200

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1260

ttcgcagcct atcgctcctg ataa                                            1284


<210>  44
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR1ĺУźģ

<400>  44
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gattggatgt atttatcctg gaaatgtcaa tactaactat      180

aatgagaagt tcaaggacag ggccaccctg accgtagaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt atttctgtac aagatcacac      300

tacggcctcg actggaactt cgatgtctgg ggccaaggga ccacggtcac cgtctcctca      360

ggtggaggcg gttcaggcgg aggtggcagc ggcggtggcg ggtcggacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccatgcc      480

agtcaaaaca tttatgtttg gttaaactgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct ataaggcttc caacctgcac acaggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagggtca aacttatccg tacacgttcg gcggagggac caaggtggag      720

atcaaagagt ccaaatatgg tcccccatgc ccaccatgcc caattgaagt tatgtatcct      780

cctccttacc tagacaatga gaagagcaat ggaaccatta tccatgtgaa agggaaacac      840

ctttgtccaa gtcccctatt tcccggacct tctaagccct tttgggtgct ggtggtggtt      900

ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggtg      960

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     1020

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc     1080

tcctgataa                                                             1089


<210>  45
<211>  1092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR2ĺУźģ

<400>  45
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gattggatgt atttatcctg gaaatgtcaa tactaactat      180

aatgagaagt tcaaggacag ggccaccctg accgtagaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt atttctgtac aagatcacac      300

tacggcctcg actggaactt cgatgtctgg ggccaaggga ccacggtcac cgtctcctca      360

ggtggaggcg gttcaggcgg aggtggcagc ggcggtggcg ggtcggacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccatgcc      480

agtcaaaaca tttatgtttg gttaaactgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct ataaggcttc caacctgcac acaggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagggtca aacttatccg tacacgttcg gcggagggac caaggtggag      720

atcaaagagt ccaaatatgg tcccccatgc ccaccatgcc caattgaagt tatgtatcct      780

cctccttacc tagacaatga gaagagcaat ggaaccatta tccatgtgaa agggaaacac      840

ctttgtccaa gtcccctatt tcccggacct tctaagccct tttgggtgct ggtggtggtt      900

ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggtg      960

aaacggggca gaaagaagct cctgtatata ttcaaacaac catttatgag accagtacaa     1020

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1080

gaactgtgat aa                                                         1092


<210>  46
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR3ĺУźģ

<400>  46
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gattggatgt atttatcctg gaaatgtcaa tactaactat      180

aatgagaagt tcaaggacag ggccaccctg accgtagaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt atttctgtac aagatcacac      300

tacggcctcg actggaactt cgatgtctgg ggccaaggga ccacggtcac cgtctcctca      360

ggtggaggcg gttcaggcgg aggtggcagc ggcggtggcg ggtcggacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccatgcc      480

agtcaaaaca tttatgtttg gttaaactgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct ataaggcttc caacctgcac acaggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagggtca aacttatccg tacacgttcg gcggagggac caaggtggag      720

atcaaagagt ccaaatatgg tcccccatgc ccaccatgcc caattgaagt tatgtatcct      780

cctccttacc tagacaatga gaagagcaat ggaaccatta tccatgtgaa agggaaacac      840

ctttgtccaa gtcccctatt tcccggacct tctaagccct tttgggtgct ggtggtggtt      900

ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggtg      960

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     1020

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc     1080

tccaaacggg gcagaaagaa gctcctgtat atattcaaac aaccatttat gagaccagta     1140

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1200

tgtgaactgt gataa                                                      1215


<210>  47
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR4ĺУźģ

<400>  47
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gattggatgt atttatcctg gaaatgtcaa tactaactat      180

aatgagaagt tcaaggacag ggccaccctg accgtagaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt atttctgtac aagatcacac      300

tacggcctcg actggaactt cgatgtctgg ggccaaggga ccacggtcac cgtctcctca      360

ggtggaggcg gttcaggcgg aggtggcagc ggcggtggcg ggtcggacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccatgcc      480

agtcaaaaca tttatgtttg gttaaactgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct ataaggcttc caacctgcac acaggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagggtca aacttatccg tacacgttcg gcggagggac caaggtggag      720

atcaaagagt ccaaatatgg tcccccatgc ccaccatgcc caattgaagt tatgtatcct      780

cctccttacc tagacaatga gaagagcaat ggaaccatta tccatgtgaa agggaaacac      840

ctttgtccaa gtcccctatt tcccggacct tctaagccct tttgggtgct ggtggtggtt      900

ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggtg      960

aaacggggca gaaagaagct cctgtatata ttcaaacaac catttatgag accagtacaa     1020

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1080

gaactgagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     1140

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     1200

tatcgctcct gataa                                                      1215


<210>  48
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Muc1 G1 CARİ

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Glu Val Gln Leu Gln Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr 
65                  70                  75                  80  


Ala Thr His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Ser 
    130                 135                 140                 


Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Asp Ile Val Val Thr Gln 
145                 150                 155                 160 


Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys 
                165                 170                 175     


Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val 
            180                 185                 190         


Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn 
        195                 200                 205             


Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly 
    210                 215                 220                 


Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala 
225                 230                 235                 240 


Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Thr Val Leu Gly Ser Glu Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
305                 310                 315                 320 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Val 
                485                 490                 495     


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            500                 505                 510         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        515                 520                 525             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    530                 535                 540                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
545                 550                 555                 560 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Lys 
                565                 570                 575     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            580                 585                 590         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        595                 600                 605             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    610                 615                 620                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
625                 630                 635                 640 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                645                 650                 655     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            660                 665                 670         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        675                 680                 685             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    690                 695                 700                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
705                 710                 715                 720 


Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 


<210>  49
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Muc1 G1 CARĺ

<400>  49
ccatgcccac catgcccagc acctcccgtg gccggaccat cagtcttcct gttcccccca       60

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      120

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag ttccagagca cgtaccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      300

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag      360

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg      480

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      540

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg      660

ggtaaattcg tgccggtctt cctgccagcg aagcccacca cgacgccagc gccgcgacca      720

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg      780

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc      840

tgggcgcccc tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac      900

tgcaaccaca aacggggcag aaagaagctc ctgtatatat tcaaacaacc atttatgaga      960

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1020

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1080

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1140

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1200

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1260

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1320

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              1371


<210>  50
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Muc1 G2 CARĺ

<400>  50
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagcgagg tccagctgca gcagtcagga ggaggcttgg tgcaacctgg aggatccatg      120

aaactctcct gtgttgcctc tggattcact ttcagtaact actggatgaa ctgggtccgc      180

cagtctccag agaaggggct tgagtgggtt gctgaaatta gattgaaatc taataattat      240

gcaacacatt atgcggagtc tgtgaaaggg aggttcacca tctcaagaga tgattccaaa      300

agtagtgtct acctgcaaat gaacaactta agagctgaag acactggcat ttattactgt      360

acctttggta actcctttgc ttactggggc caagggacca cggtcaccgt ctcctcaggt      420

ggttctggtt ctggcggctc cggttccggt ggatccggct ctgatatcgt tgtgactcag      480

gaatctgcac tcaccacatc acctggtgaa acagtcacac tcacttgtcg ctcaagtact      540

ggggctgtta caactagtaa ctatgccaac tgggtccaag aaaaaccaga tcatttattc      600

actggtctaa taggtggtac caacaaccga gcaccaggtg ttcctgccag attctcaggc      660

tccctgattg gagacaaggc tgccctcacc atcacagggg cacagactga ggatgaggca      720

atatatttct gtgctctatg gtacagcaac cattgggtgt tcggtggagg aaccaaactg      780

actgtcctag gatccgagga gtccaaatat ggtcccccat gcccaccatg cccagcacct      840

cccgtggccg gaccatcagt cttcctgttc cccccaaaac ccaaggacac tctcatgatc      900

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccaggaaga ccccgaggtc      960

cagttcaact ggtacgtgga tggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1020

gagcagttcc agagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1080

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccgtc ctccatcgag     1140

aaaaccatct ccaaagccaa agggcagccc cgagagccac aggtgtacac cctgccccca     1200

tcccaggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1260

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1320

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaggct aaccgtggac     1380

aagagcaggt ggcaggaggg gaatgtcttc tcatgctccg tgatgcatga ggctctgcac     1440

aaccactaca cacagaagag cctctccctg tctctgggta aattcgtgcc ggtcttcctg     1500

ccagcgaagc ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1560

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1620

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccctggc cgggacttgt     1680

ggggtccttc tcctgtcact ggttatcacc ctttactgca accacaaacg gggcagaaag     1740

aagctcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1800

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1860

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1920

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1980

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     2040

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     2100

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     2160

cttcacatgc aggccctgcc ccctcgc                                         2187


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28-Fļ

<400>  51
gcttctggat acaccttc                                                     18


<210>  52
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28-Rļ

<400>  52
ccttgaactt ctcattatag ttag                                              24


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ̽Taqmanеļ

<400>  53
aatacatcca atccactcaa gcc                                               23


<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8źĵİ

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser 
            20          


<210>  55
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40⼤͵İ

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  56
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4Fc CH2CH3İ

<400>  56

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  57
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR1İУźģ

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        515                 520                 525             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    530                 535                 540                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
545                 550                 555                 560 


Arg Asp Phe Ala Ala Tyr Arg Ser 
                565             


<210>  58
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   40DCR2İУźģ

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
        515                 520                 525             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    530                 535                 540                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
545                 550                 555                 560 


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                565                 


<210>  59
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR3İУźģ

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        515                 520                 525             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    530                 535                 540                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
545                 550                 555                 560 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
                565                 570                 575     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            580                 585                 590         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  60
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR4İУźģ

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
        515                 520                 525             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    530                 535                 540                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
545                 550                 555                 560 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Ser Lys Arg Ser Arg Leu 
                565                 570                 575     


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
            580                 585                 590         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        595                 600                 605             


Arg Ser 
    610 


<210>  61
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR1İУźģ

<400>  61

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser 
545     


<210>  62
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR2İУźģ

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
            500                 505                 510         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        515                 520                 525             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    530                 535                 540                 


Cys Glu Leu 
545         


<210>  63
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR3İУźģ

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
545                 550                 555                 560 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                565                 570                 575     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            580                 585             


<210>  64
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR4İУźģ

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
            500                 505                 510         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        515                 520                 525             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    530                 535                 540                 


Cys Glu Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
545                 550                 555                 560 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                565                 570                 575     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            580                 585             


<210>  65
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR1ĺУźģ

<400>  65
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1620

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1680

cgcgacttcg cagcctatcg ctcc                                            1704


<210>  66
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR2ĺУźģ

<400>  66
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1620

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1680

cgcgacttcg cagcctatcg ctcc                                            1704


<210>  67
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR3ĺУźģ

<400>  67
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1620

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1680

cgcgacttcg cagcctatcg ctccaaacgg ggcagaaaga agctcctgta tatattcaaa     1740

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1800

ccagaagaag aagaaggagg atgtgaactg                                      1830


<210>  68
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR4ĺУźģ

<400>  68
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaaacggggc agaaagaagc tcctgtatat attcaaacaa     1620

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1680

gaagaagaag aaggaggatg tgaactgagg agtaagagga gcaggctcct gcacagtgac     1740

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1800

ccaccacgcg acttcgcagc ctatcgctcc                                      1830


<210>  69
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR1ĺУźģ

<400>  69
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1560

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1620

ttcgcagcct atcgctcc                                                   1638


<210>  70
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR2ĺУźģ

<400>  70
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1560

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1620

ttcgcagcct atcgctcc                                                   1638


<210>  71
<211>  1764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR3ĺУźģ

<400>  71
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1560

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1620

ttcgcagcct atcgctccaa acggggcaga aagaagctcc tgtatatatt caaacaacca     1680

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1740

gaagaagaag gaggatgtga actg                                            1764


<210>  72
<211>  1764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR4ĺУźģ

<400>  72
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaaacg gggcagaaag aagctcctgt atatattcaa acaaccattt     1560

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1620

gaagaaggag gatgtgaact gaggagtaag aggagcaggc tcctgcacag tgactacatg     1680

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1740

cgcgacttcg cagcctatcg ctcc                                            1764


<210>  73
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR G1 CARİ

<400>  73

Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Ser Asp Ile Leu Leu Thr Gln Ser Pro 
            20                  25                  30          


Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr 
    50                  55                  60                  


Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
65                  70                  75                  80  


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
                165                 170                 175     


Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
        195                 200                 205             


Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro 
            260                 265                 270         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  74
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR G1 CARĺ

<400>  74
gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccga gcgacatctt gctgactcag tctccagtca tcctgtctgt gagtccagga      120

gaaagagtca gtttctcctg cagggccagt cagagtattg gcacaaacat acactggtat      180

cagcaaagaa caaatggttc tccaaggctt ctcataaagt atgcttctga gtctatctct      240

gggatccctt ccaggtttag tggcagtgga tcagggacag attttactct tagcatcaac      300

agtgtggagt ctgaagatat tgcagattat tactgtcaac aaaataataa ctggccaacc      360

acgttcggtg ctgggaccaa gctggagctg aaaggtggag gcggttcagg cggaggtggc      420

agcggcggtg gcgggtcgca ggtgcagctg aagcagtcag gacctggcct agtgcagccc      480

tcacagagcc tgtccatcac ctgcacagtc tctggtttct cattaactaa ctatggtgta      540

cactgggttc gccagtctcc aggaaagggt ctggagtggc tgggagtgat atggagtggt      600

ggaaacacag actataatac acctttcaca tccagactga gcatcaacaa ggacaattcc      660

aagagccaag ttttctttaa aatgaacagt ctgcaatcta atgacacagc catatattac      720

tgtgccagag ccctcaccta ctatgattac gagtttgctt actggggcca agggactctg      780

gtcactgtct cttcgttcgt gccggtcttc ctgccagcga agcccaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgcccct ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaaccacag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1080

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1140

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctga     1500

taa                                                                   1503


<210>  75
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR G2 CARĺ

<400>  75
gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccga gcgacatctt gctgactcag tctccagtca tcctgtctgt gagtccagga      120

gaaagagtca gtttctcctg cagggccagt cagagtattg gcacaaacat acactggtat      180

cagcaaagaa caaatggttc tccaaggctt ctcataaagt atgcttctga gtctatctct      240

gggatccctt ccaggtttag tggcagtgga tcagggacag attttactct tagcatcaac      300

agtgtggagt ctgaagatat tgcagattat tactgtcaac aaaataataa ctggccaacc      360

acgttcggtg ctgggaccaa gctggagctg aaaggtggag gcggttcagg cggaggtggc      420

agcggcggtg gcgggtcgca ggtgcagctg aagcagtcag gacctggcct agtgcagccc      480

tcacagagcc tgtccatcac ctgcacagtc tctggtttct cattaactaa ctatggtgta      540

cactgggttc gccagtctcc aggaaagggt ctggagtggc tgggagtgat atggagtggt      600

ggaaacacag actataatac acctttcaca tccagactga gcatcaacaa ggacaattcc      660

aagagccaag ttttctttaa aatgaacagt ctgcaatcta atgacacagc catatattac      720

tgtgccagag ccctcaccta ctatgattac gagtttgctt actggggcca agggactctg      780

gtcactgtct cttcgttcgt gccggtcttc ctgccagcga agcccaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgcccct ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaaccacag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1080

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1140

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctga     1500

taa                                                                   1503


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD40-Fļ

<400>  76
acctcctgat ctatactg                                                     18


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD40-Rļ

<400>  77
gatggtgaga gtgaaatc                                                     18


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ̽Taqmanеļ

<400>  78
cactgccgct gaaccttgat g                                                 21


