                               SEQUENCE LISTING

<110> GENENTECH, INC.
 
<120> USE OF PILRA BINDING AGENTS FOR TREATMENT OF A DISEASE

<130> P34607-WO

<140>
<141>

<150> 62/609,852
<151> 2017-12-22

<160> 71    

<170> PatentIn version 3.5

<210> 1
<211> 303
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
145                 150                 155                 160 


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
                165                 170                 175     


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
            180                 185                 190         


Ser Leu Glu Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly 
        195                 200                 205             


Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys 
    210                 215                 220                 


Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln 
225                 230                 235                 240 


Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr 
                245                 250                 255     


Asp Pro Lys Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu 
            260                 265                 270         


Ala Leu Ser Ser Ser Thr Ser Pro Arg Ala Pro Pro Ser His Arg Pro 
        275                 280                 285             


Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
    290                 295                 300             


<210> 2
<211> 303
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
145                 150                 155                 160 


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
                165                 170                 175     


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
            180                 185                 190         


Ser Leu Glu Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly 
        195                 200                 205             


Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys 
    210                 215                 220                 


Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln 
225                 230                 235                 240 


Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr 
                245                 250                 255     


Asp Pro Lys Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu 
            260                 265                 270         


Ala Leu Ser Ser Ser Thr Ser Pro Arg Ala Pro Pro Ser His Arg Pro 
        275                 280                 285             


Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
    290                 295                 300             


<210> 3
<211> 303
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
145                 150                 155                 160 


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
                165                 170                 175     


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
            180                 185                 190         


Ser Leu Glu Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly 
        195                 200                 205             


Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys 
    210                 215                 220                 


Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln 
225                 230                 235                 240 


Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr 
                245                 250                 255     


Asp Pro Lys Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu 
            260                 265                 270         


Ala Leu Ser Ser Ser Thr Leu Pro Arg Ala Pro Pro Ser His Arg Pro 
        275                 280                 285             


Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
    290                 295                 300             


<210> 4
<211> 650
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly 
1               5                   10                  15      


Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg 
            20                  25                  30          


Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala 
        35                  40                  45              


Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Thr 
    50                  55                  60                  


Leu His Arg Asp Leu Arg Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg 
65                  70                  75                  80  


Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg 
                85                  90                  95      


Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Thr Gln 
            100                 105                 110         


Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys 
        115                 120                 125             


Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu 
    130                 135                 140                 


Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His 
145                 150                 155                 160 


Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Thr Arg Arg His Gln Glu 
                165                 170                 175     


Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly 
            180                 185                 190         


Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val 
        195                 200                 205             


Cys Cys Pro Pro Pro Gly Thr Pro Asp Pro Ser Gly Thr Ala Val Gly 
    210                 215                 220                 


Asp Pro Ser Thr Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala 
225                 230                 235                 240 


Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr 
                245                 250                 255     


Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Thr Val Pro Pro 
            260                 265                 270         


Pro Ser Ser His Thr Leu Ala Val Val Gly Lys Val Thr Pro Thr Pro 
        275                 280                 285             


Arg Pro Thr Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile 
    290                 295                 300                 


Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg 
305                 310                 315                 320 


Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp 
                325                 330                 335     


Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu 
            340                 345                 350         


His Phe Gln Ser Ile Leu Gln Thr Leu Glu Glu Gln Val Ser Gly Glu 
        355                 360                 365             


Arg Gln Arg Leu Val Glu Thr His Ala Thr Arg Val Ile Ala Leu Ile 
    370                 375                 380                 


Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln 
385                 390                 395                 400 


Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr 
                405                 410                 415     


Leu Arg Ala Glu Gln Lys Glu Gln Arg His Thr Leu Arg His Tyr Gln 
            420                 425                 430         


His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln 
        435                 440                 445             


Val His Thr His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu 
    450                 455                 460                 


Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln 
465                 470                 475                 480 


Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu 
                485                 490                 495     


Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro 
            500                 505                 510         


Pro Asp Ser Lys Asp Asp Thr Pro Met Thr Leu Pro Lys Gly Ser Thr 
        515                 520                 525             


Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu Glu 
    530                 535                 540                 


Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro Phe 
545                 550                 555                 560 


His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Thr Gly 
                565                 570                 575     


Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly Gly 
            580                 585                 590         


Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys Pro 
        595                 600                 605             


Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu Thr 
    610                 615                 620                 


Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu Asn 
625                 630                 635                 640 


Pro Thr Tyr Arg Phe Leu Glu Glu Arg Pro 
                645                 650 


<210> 5
<211> 224
<212> PRT
<213> Homo sapiens

<400> 5
Met Pro Leu Thr Pro Glu Pro Pro Ser Gly Arg Val Glu Gly Pro Pro 
1               5                   10                  15      


Ala Trp Glu Ala Ala Pro Trp Pro Ser Leu Pro Cys Gly Pro Cys Ile 
            20                  25                  30          


Pro Ile Met Leu Val Leu Ala Thr Leu Ala Ala Leu Phe Ile Leu Thr 
        35                  40                  45              


Thr Ala Val Leu Ala Glu Arg Leu Phe Arg Arg Ala Leu Arg Pro Asp 
    50                  55                  60                  


Pro Ser His Arg Ala Pro Thr Leu Val Trp Arg Pro Gly Gly Glu Leu 
65                  70                  75                  80  


Trp Ile Glu Pro Met Gly Thr Ala Arg Glu Arg Ser Glu Asp Trp Tyr 
                85                  90                  95      


Gly Ser Ala Val Pro Leu Leu Thr Asp Arg Ala Pro Glu Pro Pro Thr 
            100                 105                 110         


Gln Val Gly Thr Leu Glu Ala Arg Ala Thr Ala Pro Pro Ala Pro Ser 
        115                 120                 125             


Ala Pro Asn Ser Ala Pro Ser Asn Leu Gly Pro Gln Thr Val Leu Glu 
    130                 135                 140                 


Val Pro Ala Arg Ser Thr Phe Trp Gly Pro Gln Pro Trp Glu Gly Arg 
145                 150                 155                 160 


Pro Pro Ala Thr Gly Leu Val Ser Trp Ala Glu Pro Glu Gln Arg Pro 
                165                 170                 175     


Glu Ala Ser Val Gln Phe Gly Ser Pro Gln Ala Arg Arg Gln Arg Pro 
            180                 185                 190         


Gly Ser Pro Asp Pro Glu Trp Gly Leu Gln Pro Arg Val Thr Leu Glu 
        195                 200                 205             


Gln Ile Ser Ala Phe Trp Lys Arg Glu Gly Arg Thr Ser Val Gly Phe 
    210                 215                 220                 


<210> 6
<211> 1744
<212> PRT
<213> Homo sapiens

<400> 6
Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Pro  Cys Pro Val Leu Asp  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210> 7
<211> 1744
<212> PRT
<213> Homo sapiens

<400> 7
Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210> 8
<211> 293
<212> PRT
<213> Homo sapiens

<400> 8
Met Asp Thr Thr Arg Tyr Ser Lys Trp Gly Gly Ser Ser Glu Glu Val 
1               5                   10                  15      


Pro Gly Gly Pro Trp Gly Arg Trp Val His Trp Ser Arg Arg Pro Leu 
            20                  25                  30          


Phe Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu Trp Ala Val Ile 
        35                  40                  45              


Leu Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala Leu Leu 
    50                  55                  60                  


Asp Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr Ala Ala 
65                  70                  75                  80  


Leu Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His Ser Cys Cys Ser 
                85                  90                  95      


Gly Thr Gln Ala Gln Leu Gln Thr Thr Arg Ala Glu Leu Gly Glu Ala 
            100                 105                 110         


Gln Ala Lys Leu Met Glu Gln Glu Ser Ala Leu Arg Glu Leu Arg Glu 
        115                 120                 125             


Arg Val Thr Gln Gly Leu Ala Glu Ala Gly Arg Gly Arg Glu Asp Val 
    130                 135                 140                 


Arg Thr Glu Leu Phe Arg Ala Leu Glu Ala Val Arg Leu Gln Asn Asn 
145                 150                 155                 160 


Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Ser Phe Glu Gly Ser Cys 
                165                 170                 175     


Tyr Phe Phe Ser Val Pro Lys Thr Thr Trp Ala Ala Ala Gln Asp His 
            180                 185                 190         


Cys Ala Asp Ala Ser Ala His Leu Val Ile Val Gly Gly Leu Asp Glu 
        195                 200                 205             


Gln Gly Phe Leu Thr Arg Asn Thr Arg Gly Arg Gly Tyr Trp Leu Gly 
    210                 215                 220                 


Leu Arg Ala Val Arg His Leu Gly Lys Val Gln Gly Tyr Gln Trp Val 
225                 230                 235                 240 


Asp Gly Val Ser Leu Ser Phe Ser His Trp Asn Gln Gly Glu Pro Asn 
                245                 250                 255     


Asp Ala Trp Gly Arg Glu Asn Cys Val Met Met Leu His Thr Gly Leu 
            260                 265                 270         


Trp Asn Asp Ala Pro Cys Asp Ser Glu Lys Asp Gly Trp Ile Cys Glu 
        275                 280                 285             


Lys Arg His Asn Cys 
    290             


<210> 9
<211> 742
<212> PRT
<213> Homo sapiens

<400> 9
Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210> 10
<211> 895
<212> PRT
<213> Homo sapiens

<400> 10
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210> 11
<211> 441
<212> PRT
<213> Homo sapiens

<400> 11
Met Leu Leu Pro Gly Arg Ala Arg Gln Pro Pro Thr Pro Gln Pro Val 
1               5                   10                  15      


Gln His Pro Gly Leu Arg Arg Gln Val Glu Pro Pro Gly Gln Leu Leu 
            20                  25                  30          


Arg Leu Phe Tyr Cys Thr Val Leu Val Cys Ser Lys Glu Ile Ser Ala 
        35                  40                  45              


Leu Thr Asp Phe Ser Gly Tyr Leu Thr Lys Leu Leu Gln Asn His Thr 
    50                  55                  60                  


Thr Tyr Ala Cys Asp Gly Asp Tyr Leu Asn Leu Gln Cys Pro Arg His 
65                  70                  75                  80  


Ser Thr Ile Ser Val Gln Ser Ala Phe Tyr Gly Gln Asp Tyr Gln Met 
                85                  90                  95      


Cys Ser Ser Gln Lys Pro Ala Ser Gln Arg Glu Asp Ser Leu Thr Cys 
            100                 105                 110         


Val Ala Ala Thr Thr Phe Gln Lys Val Leu Asp Glu Cys Gln Asn Gln 
        115                 120                 125             


Arg Ala Cys His Leu Leu Val Asn Ser Arg Val Phe Gly Pro Asp Leu 
    130                 135                 140                 


Cys Pro Gly Ser Ser Lys Tyr Leu Leu Val Ser Phe Lys Cys Gln Pro 
145                 150                 155                 160 


Asn Glu Leu Lys Asn Lys Thr Val Cys Glu Asp Gln Glu Leu Lys Leu 
                165                 170                 175     


His Cys His Glu Ser Lys Phe Leu Asn Ile Tyr Ser Ala Thr Tyr Gly 
            180                 185                 190         


Arg Arg Thr Gln Glu Arg Asp Ile Cys Ser Ser Lys Ala Glu Arg Leu 
        195                 200                 205             


Pro Pro Phe Asp Cys Leu Ser Tyr Ser Ala Leu Gln Val Leu Ser Arg 
    210                 215                 220                 


Arg Cys Tyr Gly Lys Gln Arg Cys Lys Ile Ile Val Asn Asn His His 
225                 230                 235                 240 


Phe Gly Ser Pro Cys Leu Pro Gly Val Lys Lys Tyr Leu Thr Val Thr 
                245                 250                 255     


Tyr Ala Cys Val Pro Lys Asn Ile Leu Thr Ala Ile Asp Pro Ala Ile 
            260                 265                 270         


Ala Asn Leu Lys Pro Ser Leu Lys Gln Lys Asp Gly Glu Tyr Gly Ile 
        275                 280                 285             


Asn Phe Asp Pro Ser Gly Ser Lys Val Leu Arg Lys Asp Gly Ile Leu 
    290                 295                 300                 


Val Ser Asn Ser Leu Ala Ala Phe Ala Tyr Ile Arg Ala His Pro Glu 
305                 310                 315                 320 


Arg Ala Ala Leu Leu Phe Val Ser Ser Val Cys Ile Gly Leu Ala Leu 
                325                 330                 335     


Thr Leu Cys Ala Leu Val Ile Arg Glu Ser Cys Ala Lys Asp Phe Arg 
            340                 345                 350         


Asp Leu Gln Leu Gly Arg Glu Gln Leu Val Pro Gly Ser Asp Lys Val 
        355                 360                 365             


Glu Glu Asp Ser Glu Asp Glu Glu Glu Glu Glu Asp Pro Ser Glu Ser 
    370                 375                 380                 


Asp Phe Pro Gly Glu Leu Ser Gly Phe Cys Arg Thr Ser Tyr Pro Ile 
385                 390                 395                 400 


Tyr Ser Ser Ile Glu Ala Ala Glu Leu Ala Glu Arg Ile Glu Arg Arg 
                405                 410                 415     


Glu Gln Ile Ile Gln Glu Ile Trp Met Asn Ser Gly Leu Asp Thr Ser 
            420                 425                 430         


Leu Pro Arg Asn Met Gly Gln Phe Tyr 
        435                 440     


<210> 12
<211> 321
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg 
1               5                   10                  15      


Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala 
            20                  25                  30          


Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp 
        35                  40                  45              


Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val 
    50                  55                  60                  


Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala 
65                  70                  75                  80  


Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg 
                85                  90                  95      


Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn 
            100                 105                 110         


Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu 
        115                 120                 125             


Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu 
    130                 135                 140                 


Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys 
145                 150                 155                 160 


Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr 
                165                 170                 175     


Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp 
            180                 185                 190         


Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp 
        195                 200                 205             


Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg 
    210                 215                 220                 


Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val 
225                 230                 235                 240 


Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly 
                245                 250                 255     


Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe 
            260                 265                 270         


Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys 
        275                 280                 285             


Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser 
    290                 295                 300                 


Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His 
305                 310                 315                 320 


Ser 
    


<210> 13
<211> 904
<212> PRT
<213> Herpes simplex virus 1

<400> 13
Met His Gln Gly Ala Pro Ser Trp Gly Arg Arg Trp Phe Val Val Trp 
1               5                   10                  15      


Ala Leu Leu Gly Leu Thr Leu Gly Val Leu Val Ala Ser Ala Ala Pro 
            20                  25                  30          


Thr Ser Pro Gly Thr Pro Gly Val Ala Ala Ala Thr Gln Ala Ala Asn 
        35                  40                  45              


Gly Gly Pro Ala Thr Pro Ala Pro Pro Pro Leu Gly Ala Ala Pro Thr 
    50                  55                  60                  


Gly Asp Pro Lys Pro Lys Lys Asn Lys Lys Pro Lys Asn Pro Thr Pro 
65                  70                  75                  80  


Pro Arg Pro Ala Gly Asp Asn Ala Thr Val Ala Ala Gly His Ala Thr 
                85                  90                  95      


Leu Arg Glu His Leu Arg Asp Ile Lys Ala Glu Asn Thr Asp Ala Asn 
            100                 105                 110         


Phe Tyr Val Cys Pro Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu 
        115                 120                 125             


Gln Pro Arg Arg Cys Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu 
    130                 135                 140                 


Gly Ile Ala Val Val Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Ala Thr Met Tyr Tyr Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly 
                165                 170                 175     


His Arg Tyr Ser Gln Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val 
            180                 185                 190         


Pro Phe Glu Glu Val Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg 
        195                 200                 205             


Ser Thr Ala Lys Tyr Val Arg Asn Asn Leu Glu Thr Thr Ala Phe His 
    210                 215                 220                 


Arg Asp Asp His Glu Thr Asp Met Glu Leu Lys Pro Ala Asn Ala Ala 
225                 230                 235                 240 


Thr Arg Thr Ser Arg Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro 
                245                 250                 255     


Ser Arg Val Glu Ala Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile 
            260                 265                 270         


Val Glu Glu Val Asp Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val 
        275                 280                 285             


Leu Ala Thr Gly Asp Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg 
    290                 295                 300                 


Glu Gly Ser His Thr Glu His Thr Thr Tyr Ala Ala Asp Arg Phe Lys 
305                 310                 315                 320 


Gln Val Asp Gly Phe Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala 
                325                 330                 335     


Thr Ala Pro Thr Thr Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val 
            340                 345                 350         


Ala Trp Asp Trp Val Pro Lys Arg Pro Ser Val Cys Thr Met Thr Lys 
        355                 360                 365             


Trp Gln Glu Val Asp Glu Met Leu Arg Ser Glu Tyr Gly Gly Ser Phe 
    370                 375                 380                 


Arg Phe Ser Ser Asp Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr 
385                 390                 395                 400 


Glu Tyr Pro Leu Ser Arg Val Asp Leu Gly Asp Cys Ile Gly Lys Asp 
                405                 410                 415     


Ala Arg Asp Ala Met Asp Arg Ile Phe Ala Arg Arg Tyr Asn Ala Thr 
            420                 425                 430         


His Ile Lys Val Gly Gln Pro Gln Tyr Tyr Gln Ala Asn Gly Gly Phe 
        435                 440                 445             


Leu Ile Ala Tyr Gln Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr 
    450                 455                 460                 


Val Arg Glu His Leu Arg Glu Gln Ser Arg Lys Pro Pro Asn Pro Thr 
465                 470                 475                 480 


Pro Pro Pro Pro Gly Ala Ser Ala Asn Ala Ser Val Glu Arg Ile Lys 
                485                 490                 495     


Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His 
            500                 505                 510         


Ile Gln Arg His Val Asn Asp Met Leu Gly Arg Val Ala Ile Ala Trp 
        515                 520                 525             


Cys Glu Leu Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys 
    530                 535                 540                 


Leu Asn Pro Asn Ala Ile Ala Ser Val Thr Val Gly Arg Arg Val Ser 
545                 550                 555                 560 


Ala Arg Met Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val 
                565                 570                 575     


Ala Ala Asp Asn Val Ile Val Gln Asn Ser Met Arg Ile Ser Ser Arg 
            580                 585                 590         


Pro Gly Ala Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp 
        595                 600                 605             


Gln Gly Pro Leu Val Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg 
    610                 615                 620                 


Leu Thr Arg Asp Ala Ile Glu Pro Cys Thr Val Gly His Arg Arg Tyr 
625                 630                 635                 640 


Phe Thr Phe Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser 
                645                 650                 655     


His Gln Leu Ser Arg Ala Asp Ile Thr Thr Val Ser Thr Phe Ile Asp 
            660                 665                 670         


Leu Asn Ile Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val 
        675                 680                 685             


Tyr Thr Arg His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu 
    690                 695                 700                 


Val Gln Arg Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp 
705                 710                 715                 720 


Thr Val Ile His Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Gly 
                725                 730                 735     


Ala Phe Phe Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val 
            740                 745                 750         


Val Met Gly Ile Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser 
        755                 760                 765             


Ser Phe Met Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val 
    770                 775                 780                 


Leu Ala Gly Leu Ala Ala Ala Phe Phe Ala Phe Arg Tyr Val Met Arg 
785                 790                 795                 800 


Leu Gln Ser Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu 
                805                 810                 815     


Leu Lys Asn Pro Thr Asn Pro Asp Ala Ser Gly Glu Gly Glu Glu Gly 
            820                 825                 830         


Gly Asp Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Lys 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ala Lys Val Thr Asp Met Val 
865                 870                 875                 880 


Met Arg Lys Arg Arg Asn Thr Asn Tyr Thr Gln Val Pro Asn Lys Asp 
                885                 890                 895     


Gly Asp Ala Asp Glu Asp Asp Leu 
            900                 


<210> 14
<211> 866
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210> 15
<211> 590
<212> PRT
<213> Homo sapiens

<400> 15
Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly 
1               5                   10                  15      


Pro Arg Thr Cys Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Ala Ser Val Ile Ala Arg Gly Lys Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Pro Leu Glu Thr Glu Glu Tyr Arg Leu Asp Lys Glu Gly 
    50                  55                  60                  


Leu Pro Trp Ala Arg Lys Arg Gln Asn Pro Leu Glu Pro Gly Ala Lys 
65                  70                  75                  80  


Ala Lys Phe His Ile Pro Ser Thr Val Tyr Asp Ser Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Glu Thr Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Ala Thr Gly Phe Tyr Ala Glu Pro Thr Leu Leu Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Val Thr Leu Gln Cys 
    130                 135                 140                 


Asp Thr Leu Asp Gly Leu Leu Thr Phe Val Leu Val Glu Glu Glu Gln 
145                 150                 155                 160 


Lys Leu Pro Arg Thr Leu Tyr Ser Gln Lys Leu Pro Lys Gly Pro Ser 
                165                 170                 175     


Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser Cys Arg Trp Arg 
            180                 185                 190         


Phe Arg Cys Tyr Tyr Tyr Tyr Arg Lys Asn Pro Gln Val Trp Ser Asn 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Ile Leu Val Pro Gly Val Ser Arg Lys Pro 
    210                 215                 220                 


Ser Leu Leu Ile Pro Gln Gly Ser Val Val Ala Arg Gly Gly Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Arg Ser Asp Val Gly Tyr Asp Ile Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Pro Arg 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Leu Ile 
305                 310                 315                 320 


Pro Asp Ile Pro Ala Leu Ser Val Gln Pro Gly Pro Lys Val Ala Ser 
                325                 330                 335     


Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp His Gln Ile Asp Thr 
            340                 345                 350         


Phe Phe Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Cys Leu Lys 
        355                 360                 365             


Ser Lys Tyr Gln Ser Tyr Arg His Gln Ala Glu Phe Ser Met Ser Pro 
    370                 375                 380                 


Val Thr Ser Ala Gln Gly Gly Thr Tyr Arg Cys Tyr Ser Ala Ile Arg 
385                 390                 395                 400 


Ser Tyr Pro Tyr Leu Leu Ser Ser Pro Ser Tyr Pro Gln Glu Leu Val 
                405                 410                 415     


Val Ser Gly Pro Ser Gly Asp Pro Ser Leu Ser Pro Thr Gly Ser Thr 
            420                 425                 430         


Pro Thr Pro Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Leu Asp 
        435                 440                 445             


Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Thr Gly Val Ser 
    450                 455                 460                 


Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu Arg 
465                 470                 475                 480 


His Arg His Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg Pro 
                485                 490                 495     


Ala Gly Ala Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys Arg 
            500                 505                 510         


Ala Ser Pro Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala Val 
        515                 520                 525             


Lys Asp Thr Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala Ala 
    530                 535                 540                 


Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu 
545                 550                 555                 560 


Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg Glu 
                565                 570                 575     


Pro Pro Ala Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His 
            580                 585                 590 


<210> 16
<211> 581
<212> PRT
<213> Homo sapiens

<400> 16
Met Pro Leu Lys His Tyr Leu Leu Leu Leu Val Gly Cys Gln Ala Trp 
1               5                   10                  15      


Gly Ala Gly Leu Ala Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser 
            20                  25                  30          


Arg Ala Ser Gln Val Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro 
        35                  40                  45              


Thr Pro Leu Pro Trp Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His 
    50                  55                  60                  


Ile Thr Glu Leu Asn Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile 
65                  70                  75                  80  


Ala Leu Arg Ile Glu Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala 
                85                  90                  95      


Phe Arg Asn Leu Gly Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys 
            100                 105                 110         


Leu Gln Val Leu Pro Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu 
        115                 120                 125             


Ser Leu Leu Leu Ser Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His 
    130                 135                 140                 


Phe Ser Gln Cys Ser Asn Leu Lys Glu Leu Gln Leu His Gly Asn His 
145                 150                 155                 160 


Leu Glu Tyr Ile Pro Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr 
                165                 170                 175     


Lys Leu Asn Leu Gly Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val 
            180                 185                 190         


Phe Gln His Leu Gly Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg 
        195                 200                 205             


Leu Thr Asp Ile Pro Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln 
    210                 215                 220                 


Glu Leu Ala Leu Gln Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu 
225                 230                 235                 240 


Phe His Asn Asn His Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His 
                245                 250                 255     


Ile Ser Gln Leu Pro Pro Ser Val Phe Met Gln Leu Pro Gln Leu Asn 
            260                 265                 270         


Arg Leu Thr Leu Phe Gly Asn Ser Leu Lys Glu Leu Ser Pro Gly Ile 
        275                 280                 285             


Phe Gly Pro Met Pro Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His 
    290                 295                 300                 


Ile Ser Ser Leu Pro Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln 
305                 310                 315                 320 


Val Leu Ile Leu Ser Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala 
                325                 330                 335     


Phe Asn Gly Leu Thr Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala 
            340                 345                 350         


Leu Gln Asp Leu Asp Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln 
        355                 360                 365             


Asn Ile Ser Leu Gln Asn Asn Arg Leu Arg Gln Leu Pro Gly Asn Ile 
    370                 375                 380                 


Phe Ala Asn Val Asn Gly Leu Met Ala Ile Gln Leu Gln Asn Asn Gln 
385                 390                 395                 400 


Leu Glu Asn Leu Pro Leu Gly Ile Phe Asp His Leu Gly Lys Leu Cys 
                405                 410                 415     


Glu Leu Arg Leu Tyr Asp Asn Pro Trp Arg Cys Asp Ser Asp Ile Leu 
            420                 425                 430         


Pro Leu Arg Asn Trp Leu Leu Leu Asn Gln Pro Arg Leu Gly Thr Asp 
        435                 440                 445             


Thr Val Pro Val Cys Phe Ser Pro Ala Asn Val Arg Gly Gln Ser Leu 
    450                 455                 460                 


Ile Ile Ile Asn Val Asn Val Ala Val Pro Ser Val His Val Pro Glu 
465                 470                 475                 480 


Val Pro Ser Tyr Pro Glu Thr Pro Trp Tyr Pro Asp Thr Pro Ser Tyr 
                485                 490                 495     


Pro Asp Thr Thr Ser Val Ser Ser Thr Thr Glu Leu Thr Ser Pro Val 
            500                 505                 510         


Glu Asp Tyr Thr Asp Leu Thr Thr Ile Gln Val Thr Asp Asp Arg Ser 
        515                 520                 525             


Val Trp Gly Met Thr Gln Ala Gln Ser Gly Leu Ala Ile Ala Ala Ile 
    530                 535                 540                 


Val Ile Gly Ile Val Ala Leu Ala Cys Ser Leu Ala Ala Cys Val Gly 
545                 550                 555                 560 


Cys Cys Cys Cys Lys Lys Arg Ser Gln Ala Val Leu Met Gln Met Lys 
                565                 570                 575     


Ala Pro Asn Glu Cys 
            580     


<210> 17
<211> 590
<212> PRT
<213> Homo sapiens

<400> 17
Met Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln Arg 
            20                  25                  30          


Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys Glu 
        35                  40                  45              


Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser Gln 
    50                  55                  60                  


Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn Gln 
65                  70                  75                  80  


Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn Tyr 
                85                  90                  95      


Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys Thr 
        115                 120                 125             


Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn Lys 
    130                 135                 140                 


Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu Ile 
145                 150                 155                 160 


Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg Val 
                165                 170                 175     


Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu Lys 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu His 
                245                 250                 255     


Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly Thr 
            260                 265                 270         


Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn Lys 
        275                 280                 285             


Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu Ile 
    290                 295                 300                 


Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile Cys 
305                 310                 315                 320 


Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser Thr 
                325                 330                 335     


Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser Asp 
            340                 345                 350         


Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn Thr 
        355                 360                 365             


Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile Ile 
    370                 375                 380                 


Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe Glu 
385                 390                 395                 400 


Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln Glu 
                405                 410                 415     


Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala Leu 
            420                 425                 430         


Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp Lys 
        435                 440                 445             


Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met Lys 
    450                 455                 460                 


Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser Pro 
465                 470                 475                 480 


Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr Met 
                485                 490                 495     


Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser Gly 
            500                 505                 510         


Ser Arg Glu Cys Glu Met Pro His His Met Lys Pro Leu Pro Tyr Tyr 
        515                 520                 525             


Ser Tyr Asp Gln Pro Val Ile Gly Tyr Cys Gln Ala His Gln Pro Leu 
    530                 535                 540                 


His Val Thr Lys Gly Tyr Glu Thr Val Ser Pro Glu Gln Asp Glu Ser 
545                 550                 555                 560 


Pro Gly Leu Glu Leu Gly Arg Asp His Ser Phe Ile Ala Thr Ile Ala 
                565                 570                 575     


Arg Ser Ala Ala Pro Ala Ile Tyr Leu Glu Arg Ile Ala Asn 
            580                 585                 590 


<210> 18
<211> 325
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Thr Pro Leu Pro Pro Pro Ser Pro Arg His Leu Arg Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Ser Gly Leu Val Leu Gly Ala Ala Leu Arg Gly Ala 
            20                  25                  30          


Ala Ala Gly His Pro Asp Val Ala Ala Cys Pro Gly Ser Leu Asp Cys 
        35                  40                  45              


Ala Leu Lys Arg Arg Ala Arg Cys Pro Pro Gly Ala His Ala Cys Gly 
    50                  55                  60                  


Pro Cys Leu Gln Pro Phe Gln Glu Asp Gln Gln Gly Leu Cys Val Pro 
65                  70                  75                  80  


Arg Met Arg Arg Pro Pro Gly Gly Gly Arg Pro Gln Pro Arg Leu Glu 
                85                  90                  95      


Asp Glu Ile Asp Phe Leu Ala Gln Glu Leu Ala Arg Lys Glu Ser Gly 
            100                 105                 110         


His Ser Thr Pro Pro Leu Pro Lys Asp Arg Gln Arg Leu Pro Glu Pro 
        115                 120                 125             


Ala Thr Leu Gly Phe Ser Ala Arg Gly Gln Gly Leu Glu Leu Gly Leu 
    130                 135                 140                 


Pro Ser Thr Pro Gly Thr Pro Thr Pro Thr Pro His Thr Ser Leu Gly 
145                 150                 155                 160 


Ser Pro Val Ser Ser Asp Pro Val His Met Ser Pro Leu Glu Pro Arg 
                165                 170                 175     


Gly Gly Gln Gly Asp Gly Leu Ala Leu Val Leu Ile Leu Ala Phe Cys 
            180                 185                 190         


Val Ala Gly Ala Ala Ala Leu Ser Val Ala Ser Leu Cys Trp Cys Arg 
        195                 200                 205             


Leu Gln Arg Glu Ile Arg Leu Thr Gln Lys Ala Asp Tyr Ala Thr Ala 
    210                 215                 220                 


Lys Ala Pro Gly Ser Pro Ala Ala Pro Arg Ile Ser Pro Gly Asp Gln 
225                 230                 235                 240 


Arg Leu Ala Gln Ser Ala Glu Met Tyr His Tyr Gln His Gln Arg Gln 
                245                 250                 255     


Gln Met Leu Cys Leu Glu Arg His Lys Glu Pro Pro Lys Glu Leu Asp 
            260                 265                 270         


Thr Ala Ser Ser Asp Glu Glu Asn Glu Asp Gly Asp Phe Thr Val Tyr 
        275                 280                 285             


Glu Cys Pro Gly Leu Ala Pro Thr Gly Glu Met Glu Val Arg Asn Pro 
    290                 295                 300                 


Leu Phe Asp His Ala Ala Leu Ser Ala Pro Leu Pro Ala Pro Ser Ser 
305                 310                 315                 320 


Pro Pro Ala Leu Pro 
                325 


<210> 19
<211> 282
<212> PRT
<213> Homo sapiens

<400> 19
Met Glu Ser Arg Met Trp Pro Ala Leu Leu Leu Ser His Leu Leu Pro 
1               5                   10                  15      


Leu Trp Pro Leu Leu Leu Leu Pro Leu Pro Pro Pro Ala Gln Gly Ser 
            20                  25                  30          


Ser Ser Ser Pro Arg Thr Pro Pro Ala Pro Ala Arg Pro Pro Cys Ala 
        35                  40                  45              


Arg Gly Gly Pro Ser Ala Pro Arg His Val Cys Val Trp Glu Arg Ala 
    50                  55                  60                  


Pro Pro Pro Ser Arg Ser Pro Arg Val Pro Arg Ser Arg Arg Gln Val 
65                  70                  75                  80  


Leu Pro Gly Thr Ala Pro Pro Ala Thr Pro Ser Gly Phe Glu Glu Gly 
                85                  90                  95      


Pro Pro Ser Ser Gln Tyr Pro Trp Ala Ile Val Trp Gly Pro Thr Val 
            100                 105                 110         


Ser Arg Glu Asp Gly Gly Asp Pro Asn Ser Ala Asn Pro Gly Phe Leu 
        115                 120                 125             


Asp Tyr Gly Phe Ala Ala Pro His Gly Leu Ala Thr Pro His Pro Asn 
    130                 135                 140                 


Ser Asp Ser Met Arg Gly Asp Gly Asp Gly Leu Ile Leu Gly Glu Ala 
145                 150                 155                 160 


Pro Ala Thr Leu Arg Pro Phe Leu Phe Gly Gly Arg Gly Glu Gly Val 
                165                 170                 175     


Asp Pro Gln Leu Tyr Val Thr Ile Thr Ile Ser Ile Ile Ile Val Leu 
            180                 185                 190         


Val Ala Thr Gly Ile Ile Phe Lys Phe Cys Trp Asp Arg Ser Gln Lys 
        195                 200                 205             


Arg Arg Arg Pro Ser Gly Gln Gln Gly Ala Leu Arg Gln Glu Glu Ser 
    210                 215                 220                 


Gln Gln Pro Leu Thr Asp Leu Ser Pro Ala Gly Val Thr Val Leu Gly 
225                 230                 235                 240 


Ala Phe Gly Asp Ser Pro Thr Pro Thr Pro Asp His Glu Glu Pro Arg 
                245                 250                 255     


Gly Gly Pro Arg Pro Gly Met Pro His Pro Lys Gly Ala Pro Ala Phe 
            260                 265                 270         


Gln Leu Asn Arg Ile Pro Leu Val Asn Leu 
        275                 280         


<210> 20
<211> 352
<212> PRT
<213> Homo sapiens

<400> 20
Met Leu Leu Phe Ser Val Leu Leu Leu Leu Ser Leu Val Thr Gly Thr 
1               5                   10                  15      


Gln Leu Gly Pro Arg Thr Pro Leu Pro Glu Ala Gly Val Ala Ile Leu 
            20                  25                  30          


Gly Arg Ala Arg Gly Ala His Arg Pro Gln Pro Pro His Pro Pro Ser 
        35                  40                  45              


Pro Val Ser Glu Cys Gly Asp Arg Ser Ile Phe Glu Gly Arg Thr Arg 
    50                  55                  60                  


Tyr Ser Arg Ile Thr Gly Gly Met Glu Ala Glu Val Gly Glu Phe Pro 
65                  70                  75                  80  


Trp Gln Val Ser Ile Gln Ala Arg Ser Glu Pro Phe Cys Gly Gly Ser 
                85                  90                  95      


Ile Leu Asn Lys Trp Trp Ile Leu Thr Ala Ala His Cys Leu Tyr Ser 
            100                 105                 110         


Glu Glu Leu Phe Pro Glu Glu Leu Ser Val Val Leu Gly Thr Asn Asp 
        115                 120                 125             


Leu Thr Ser Pro Ser Met Glu Ile Lys Glu Val Ala Ser Ile Ile Leu 
    130                 135                 140                 


His Lys Asp Phe Lys Arg Ala Asn Met Asp Asn Asp Ile Ala Leu Leu 
145                 150                 155                 160 


Leu Leu Ala Ser Pro Ile Lys Leu Asp Asp Leu Lys Val Pro Ile Cys 
                165                 170                 175     


Leu Pro Thr Gln Pro Gly Pro Ala Thr Trp Arg Glu Cys Trp Val Ala 
            180                 185                 190         


Gly Trp Gly Gln Thr Asn Ala Ala Asp Lys Asn Ser Val Lys Thr Asp 
        195                 200                 205             


Leu Met Lys Ala Pro Met Val Ile Met Asp Trp Glu Glu Cys Ser Lys 
    210                 215                 220                 


Met Phe Pro Lys Leu Thr Lys Asn Met Leu Cys Ala Gly Tyr Lys Asn 
225                 230                 235                 240 


Glu Ser Tyr Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
                245                 250                 255     


Thr Pro Glu Pro Gly Glu Lys Trp Tyr Gln Val Gly Ile Ile Ser Trp 
            260                 265                 270         


Gly Lys Ser Cys Gly Glu Lys Asn Thr Pro Gly Ile Tyr Thr Ser Leu 
        275                 280                 285             


Val Asn Tyr Asn Leu Trp Ile Glu Lys Val Thr Gln Leu Glu Gly Arg 
    290                 295                 300                 


Pro Phe Asn Ala Glu Lys Arg Arg Thr Ser Val Lys Gln Lys Pro Met 
305                 310                 315                 320 


Gly Ser Pro Val Ser Gly Val Pro Glu Pro Gly Ser Pro Arg Ser Trp 
                325                 330                 335     


Leu Leu Leu Cys Pro Leu Ser His Val Leu Phe Arg Ala Ile Leu Tyr 
            340                 345                 350         


<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 21
gcggccttgt gctgtagaa                                                    19


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 22
gctcccgacg tgagaatatc c                                                 21


<210> 23
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
acttccacgg gcagtc                                                       16


<210> 24
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
acttccacag gcagtc                                                       16


<210> 25
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 25
ggcctggcta tccggaga                                                     18


<210> 26
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 26
gcgcagagac atcgcga                                                      17


<210> 27
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 27
cagcacacga cttggcgttc tgtgt                                             25


<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Lys Ala Ser Gln Asn Val Gly Thr Lys Val Ala 
1               5                   10      


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Ser Ala Ser Tyr Arg Phe Ser 
1               5           


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Thr Tyr Gly Met Ser 
1               5   


<210> 32
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Arg Asp Tyr Gly Ser Ser Gln Trp Tyr Phe Asp Val 
1               5                   10          


<210> 34
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210> 35
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Ser Ala Ser Tyr Arg Tyr 
1               5       


<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Gln Gln His Tyr Thr Thr Pro Leu Thr 
1               5                   


<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Asn Tyr Trp Ile Gly 
1               5   


<210> 38
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Lys Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Ser Arg Gly His Gly Ser Asn Phe Tyr Trp Tyr Phe Asp Val 
1               5                   10                  


<210> 40
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210> 43
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Ser Tyr Trp Met Asn 
1               5   


<210> 44
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Trp Ile Tyr Gly Gly Ser Gly Asn Thr Lys Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Gly Thr Asn Phe Phe Asp Tyr 
1               5           


<210> 46
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Ile Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Lys 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Glu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 47
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Met Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asp Glu Asp Thr Ala Arg Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Gly Ser Ser Gln Trp Tyr Phe Asp Val Trp Ser 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 48
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Arg Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Pro Asp His Phe Thr Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu 
65                  70                  75                  80  


Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210> 49
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Gly Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Ala Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Arg Gly His Gly Ser Asn Phe Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 50
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 51
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly His Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Asn Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Gly Gly Ser Gly Asn Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Thr Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 52
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Ile Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Lys 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Glu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210> 53
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Met Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asp Glu Asp Thr Ala Arg Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Gly Ser Ser Gln Trp Tyr Phe Asp Val Trp Ser 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
    210                 215                 220                 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
                245                 250                 255     


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
        355                 360                 365             


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
    370                 375                 380                 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
                405                 410                 415     


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
            420                 425                 430         


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 54
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Arg Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Pro Asp His Phe Thr Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu 
65                  70                  75                  80  


Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210> 55
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Gly Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Ala Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Arg Gly His Gly Ser Asn Phe Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Ala 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
    130                 135                 140                 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
            180                 185                 190         


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
    210                 215                 220                 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
                245                 250                 255     


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
        275                 280                 285             


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
    290                 295                 300                 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
305                 310                 315                 320 


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
            340                 345                 350         


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
        355                 360                 365             


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
    370                 375                 380                 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
385                 390                 395                 400 


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
                405                 410                 415     


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
            420                 425                 430         


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
        435                 440                 445             


Arg Thr Pro Gly Lys 
    450             


<210> 56
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210> 57
<211> 446
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly His Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Asn Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Gly Gly Ser Gly Asn Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Thr Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
    210                 215                 220                 


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
                245                 250                 255     


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
            260                 265                 270         


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
    290                 295                 300                 


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
                325                 330                 335     


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
            340                 345                 350         


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
        355                 360                 365             


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
    370                 375                 380                 


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
                405                 410                 415     


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445     


<210> 58
<211> 237
<212> PRT
<213> Mus musculus

<400> 58
Met Val Ala Arg Leu Thr Ala Phe Leu Val Cys Leu Val Phe Ser Leu 
1               5                   10                  15      


Ala Thr Leu Val Gln Arg Gly Tyr Gly Asp Thr Asp Gly Phe Asn Leu 
            20                  25                  30          


Glu Asp Ala Leu Lys Glu Thr Ser Ser Val Lys Gln Arg Trp Asp His 
        35                  40                  45              


Phe Ser Thr Thr Thr Arg Arg Pro Val Thr Thr Arg Ala Pro Ala Asn 
    50                  55                  60                  


Pro Ala Glu Arg Trp Asp His Val Ala Thr Thr Thr Thr Arg Arg Pro 
65                  70                  75                  80  


Gly Thr Thr Arg Ala Pro Ser Asn Pro Met Glu Leu Asp Gly Phe Asp 
                85                  90                  95      


Leu Glu Asp Ala Leu Asp Asp Arg Asn Asp Leu Asp Gly Pro Lys Lys 
            100                 105                 110         


Pro Ser Ala Gly Glu Ala Gly Gly Trp Ser Asp Lys Asp Leu Glu Asp 
        115                 120                 125             


Ile Val Glu Gly Gly Gly Tyr Lys Pro Asp Lys Asn Lys Gly Gly Gly 
    130                 135                 140                 


Gly Tyr Gly Ser Asn Asp Asp Pro Gly Ser Gly Ile Ser Thr Glu Thr 
145                 150                 155                 160 


Gly Thr Ile Ala Gly Val Ala Ser Ala Leu Ala Met Ala Leu Ile Gly 
                165                 170                 175     


Ala Val Ser Ser Tyr Ile Ser Tyr Gln Gln Lys Lys Phe Cys Phe Ser 
            180                 185                 190         


Ile Gln Gln Gly Leu Asn Ala Asp Tyr Val Lys Gly Glu Asn Leu Glu 
        195                 200                 205             


Ala Val Val Cys Glu Glu Pro Gln Val Thr Tyr Ser Lys Gln Glu Thr 
    210                 215                 220                 


Gln Ser Ala Glu Pro Pro Pro Pro Glu Pro Pro Arg Ile 
225                 230                 235         


<210> 59
<211> 262
<212> PRT
<213> Homo sapiens

<400> 59
Met Val Ala Trp Arg Ser Ala Phe Leu Val Cys Leu Ala Phe Ser Leu 
1               5                   10                  15      


Ala Thr Leu Val Gln Arg Gly Ser Gly Asp Phe Asp Asp Phe Asn Leu 
            20                  25                  30          


Glu Asp Ala Val Lys Glu Thr Ser Ser Val Lys Gln Pro Trp Asp His 
        35                  40                  45              


Thr Thr Thr Thr Thr Thr Asn Arg Pro Gly Thr Thr Arg Ala Pro Ala 
    50                  55                  60                  


Lys Pro Pro Gly Ser Gly Leu Asp Leu Ala Asp Ala Leu Asp Asp Gln 
65                  70                  75                  80  


Asp Asp Gly Arg Arg Lys Pro Gly Ile Gly Gly Arg Glu Arg Trp Asn 
                85                  90                  95      


His Val Thr Thr Thr Thr Lys Arg Pro Val Thr Thr Arg Ala Pro Ala 
            100                 105                 110         


Asn Thr Leu Gly Asn Asp Phe Asp Leu Ala Asp Ala Leu Asp Asp Arg 
        115                 120                 125             


Asn Asp Arg Asp Asp Gly Arg Arg Lys Pro Ile Ala Gly Gly Gly Gly 
    130                 135                 140                 


Phe Ser Asp Lys Asp Leu Glu Asp Ile Val Gly Gly Gly Glu Tyr Lys 
145                 150                 155                 160 


Pro Asp Lys Gly Lys Gly Asp Gly Arg Tyr Gly Ser Asn Asp Asp Pro 
                165                 170                 175     


Gly Ser Gly Met Val Ala Glu Pro Gly Thr Ile Ala Gly Val Ala Ser 
            180                 185                 190         


Ala Leu Ala Met Ala Leu Ile Gly Ala Val Ser Ser Tyr Ile Ser Tyr 
        195                 200                 205             


Gln Gln Lys Lys Phe Cys Phe Ser Ile Gln Gln Gly Leu Asn Ala Asp 
    210                 215                 220                 


Tyr Val Lys Gly Glu Asn Leu Glu Ala Val Val Cys Glu Glu Pro Gln 
225                 230                 235                 240 


Val Lys Tyr Ser Thr Leu His Thr Gln Ser Ala Glu Pro Pro Pro Pro 
                245                 250                 255     


Pro Glu Pro Ala Arg Ile 
            260         


<210> 60
<211> 278
<212> PRT
<213> Mus musculus

<400> 60
Met Trp Ser Ala Gln Leu Leu Ser Gln Leu Leu Pro Leu Trp Pro Leu 
1               5                   10                  15      


Leu Leu Leu Ser Val Leu Pro Pro Ala Gln Gly Ser Ser His Arg Ser 
            20                  25                  30          


Pro Pro Ala Pro Ala Arg Pro Pro Cys Val Arg Gly Gly Pro Ser Ala 
        35                  40                  45              


Pro Arg His Val Cys Val Trp Glu Arg Ala Pro Pro Pro Ser Arg Ser 
    50                  55                  60                  


Pro Arg Val Pro Arg Ser Arg Arg Gln Val Val Pro Gly Thr Ala Pro 
65                  70                  75                  80  


Pro Ala Thr Pro Ser Gly Phe Glu Glu Gly Pro Pro Ser Ser Gln Tyr 
                85                  90                  95      


Pro Trp Ala Ile Val Trp Gly Pro Thr Val Ser Arg Glu Asp Gly Gly 
            100                 105                 110         


Asp Pro Asn Ser Val Asn Pro Gly Phe Leu Pro Leu Asp Tyr Gly Phe 
        115                 120                 125             


Ala Ala Pro His Gly Leu Ala Thr Pro His Pro Asn Ser Asp Ser Met 
    130                 135                 140                 


Arg Asp Asp Gly Asp Gly Leu Ile Leu Gly Glu Thr Pro Ala Thr Leu 
145                 150                 155                 160 


Arg Pro Phe Leu Phe Gly Gly Arg Gly Glu Gly Val Asp Pro Gln Leu 
                165                 170                 175     


Tyr Val Thr Ile Thr Ile Ser Ile Ile Ile Val Leu Val Ala Thr Gly 
            180                 185                 190         


Ile Ile Phe Lys Phe Cys Trp Asp Arg Ser Gln Lys Arg Arg Arg Pro 
        195                 200                 205             


Ser Gly Gln Gln Gly Ala Leu Arg Gln Glu Glu Ser Gln Gln Pro Leu 
    210                 215                 220                 


Thr Asp Leu Ser Pro Ala Gly Val Thr Val Leu Gly Ala Phe Gly Asp 
225                 230                 235                 240 


Ser Pro Thr Pro Thr Pro Asp His Glu Glu Pro Arg Gly Gly Pro Arg 
                245                 250                 255     


Pro Gly Met Pro Gln Pro Lys Gly Ala Pro Ala Phe Gln Leu Asn Arg 
            260                 265                 270         


Ile Pro Leu Val Asn Leu 
        275             


<210> 61
<211> 302
<212> PRT
<213> Mus musculus

<400> 61
Met Ala Leu Leu Ile Ser Leu Pro Gly Gly Thr Pro Ala Met Ala Gln 
1               5                   10                  15      


Ile Leu Leu Leu Leu Ser Ser Ala Cys Leu His Ala Gly Asn Ser Glu 
            20                  25                  30          


Arg Ser Asn Arg Lys Asn Gly Phe Gly Val Asn Gln Pro Glu Ser Cys 
        35                  40                  45              


Ser Gly Val Gln Gly Gly Ser Ile Asp Ile Pro Phe Ser Phe Tyr Phe 
    50                  55                  60                  


Pro Trp Lys Leu Ala Lys Asp Pro Gln Met Ser Ile Ala Trp Arg Trp 
65                  70                  75                  80  


Lys Asp Phe His Gly Glu Phe Ile Tyr Asn Ser Ser Leu Pro Phe Ile 
                85                  90                  95      


His Glu His Phe Lys Gly Arg Leu Ile Leu Asn Trp Thr Gln Gly Gln 
            100                 105                 110         


Thr Ser Gly Val Leu Arg Ile Leu Asn Leu Lys Glu Ser Asp Gln Thr 
        115                 120                 125             


Arg Tyr Phe Gly Arg Val Phe Leu Gln Thr Thr Glu Gly Ile Gln Phe 
    130                 135                 140                 


Trp Gln Ser Ile Pro Gly Thr Gln Leu Asn Val Thr Asn Ala Thr Cys 
145                 150                 155                 160 


Thr Pro Thr Thr Leu Pro Ser Thr Thr Ala Ala Thr Ser Ala His Thr 
                165                 170                 175     


Gln Asn Asp Ile Thr Glu Val Lys Ser Ala Asn Ile Gly Gly Leu Asp 
            180                 185                 190         


Leu Gln Thr Thr Val Gly Leu Ala Thr Ala Ala Ala Val Phe Leu Val 
        195                 200                 205             


Gly Val Leu Gly Leu Ile Val Phe Leu Trp Trp Lys Arg Arg Arg Gln 
    210                 215                 220                 


Gly Gln Lys Thr Lys Ala Glu Ile Pro Ala Arg Glu Pro Leu Glu Thr 
225                 230                 235                 240 


Ser Glu Lys His Glu Ser Val Gly His Glu Gly Gln Cys Met Asp Pro 
                245                 250                 255     


Lys Glu Asn Pro Lys Asp Asn Asn Ile Val Tyr Ala Ser Ile Ser Leu 
            260                 265                 270         


Ser Ser Pro Thr Ser Pro Gly Thr Ala Pro Asn Leu Pro Val His Gly 
        275                 280                 285             


Asn Pro Gln Glu Glu Thr Val Tyr Ser Ile Val Lys Ala Lys 
    290                 295                 300         


<210> 62
<211> 5
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 62
Pro Thr Pro Xaa Pro 
1               5   


<210> 63
<211> 6
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<400> 63
Pro Thr Pro Xaa Xaa Pro 
1               5       


<210> 64
<211> 6
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 64
Pro Xaa Thr Pro Xaa Pro 
1               5       


<210> 65
<211> 7
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Any amino acid

<400> 65
Pro Xaa Thr Pro Xaa Xaa Pro 
1               5           


<210> 66
<211> 7
<212> PRT
<213> Herpes simplex virus 1

<400> 66
Pro Ala Thr Pro Ala Pro Pro 
1               5           


<210> 67
<211> 7
<212> PRT
<213> Homo sapiens

<400> 67
Pro Ser Thr Pro Gly Thr Pro 
1               5           


<210> 68
<211> 7
<212> PRT
<213> Homo sapiens

<400> 68
Glu Pro Thr Pro Ala Pro Glu 
1               5           


<210> 69
<211> 7
<212> PRT
<213> Homo sapiens

<400> 69
Ser Pro Thr Pro Ala Pro Arg 
1               5           


<210> 70
<211> 7
<212> PRT
<213> Homo sapiens

<400> 70
Pro Gly Thr Pro Asp Pro Ser 
1               5           


<210> 71
<211> 7
<212> PRT
<213> Homo sapiens

<400> 71
Pro Ala Thr Pro Leu Pro Leu 
1               5           


