                         SEQUENCE LISTING

<110>  Surrozen, Inc.
       Li, Yang
       Yuan, Tom Zhiye
       Sato, Aaron Ken
       Yeh, Wen-Chen
       Xie, Liqin
       Brezski, Randall J.
       Lu, Chenggang
 
<120>  WNT SURROGATE MOLECULES AND USES THEREOEOF

<130>  SRZN-006/03WO 328202-2033

<150>  US 62/607,875
<151>  2017-12-19

<150>  US 62/641,217
<151>  2018-03-09

<150>  US 62/680,522
<151>  2018-06-04

<160>  2267  

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  1

Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Ser Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  2
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Asn 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Phe Thr Gly Gly Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Met Leu Ile Thr Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  3
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ala Ile Ser Gly Thr 
            20                  25                  30          


Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Thr Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gly Ile Ala Val Ala Ala Pro Val Asp His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  4
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Thr Tyr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  5
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  5

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Arg Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Asp 
            100                 105                 110         


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys 
225                 230 


<210>  6
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  6

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Phe Ser Gly His 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Glu Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly His Tyr His Gly Leu Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  7
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  7

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Tyr Arg 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Gly Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Met Val Arg Val Pro Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys 
225 


<210>  8
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Gly Gly Gly Ser Thr Phe Tyr Ser Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Ile Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ile Ala Arg Trp Tyr Arg Gly Asp Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  9

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Arg Ala Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Ile Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ile Ala Arg Trp Tyr Arg Gly Asp Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Glu Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ser Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Asp Gly Gly Arg Thr Ser Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Arg Val Leu Val Thr Ala Pro Ser Gly Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  11

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly Thr Trp 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asn Gly Phe Ser Thr Tyr Tyr Ser Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Ile Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ile Ala Arg Trp Tyr Arg Gly Asp Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  12

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Pro Ile Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ile Ala Arg Trp Tyr Arg Gly Asp Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  13

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ile Ala Arg Trp Tyr Arg Gly Asp Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  14

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Asn Tyr Ser Trp Phe Met Pro Ser Ser Ser Arg Leu 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  15

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Ser Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Phe Leu Ser Arg Asn Tyr Glu Ile Gln Glu Tyr Tyr Arg 
            100                 105                 110         


Tyr Gln Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Asn Gly Ala Thr Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Gly Arg Phe Gly Glu Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  17
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys 
225 


<210>  18
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Glu Val Gly Ala Thr Met Leu Gly Ile Gly Val 
            100                 105                 110         


Trp Tyr Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys 
225                 230         


<210>  19
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gly Ile Tyr 
            20                  25                  30          


Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Gly Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     


<210>  20
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Asn Tyr Tyr Gly Ser Gly Ser Tyr Pro Gly Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Asn Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys 
225     


<210>  21
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Arg 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  22
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Arg Gly Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     


<210>  23
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Val Gly Tyr Asp Gly Ser Gln Gln Phe Tyr Gly Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Thr Gly Ile Pro Met Leu Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215             


<210>  24
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Val Asn Asn Tyr Tyr Tyr Met Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  25
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Gly Tyr Ser Ser Gly Trp Tyr Arg Gly Asp Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys 
225             


<210>  26
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          


Ala Val Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Gln Gln Trp Leu Thr Gly Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  27
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gln Leu Gly Trp Ala His Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys 
225 


<210>  28
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Arg Arg Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Asn Ser Gly Ser Leu Val Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Asp Ser Ser Gly Tyr Tyr Arg Tyr Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  29
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ala Phe Ser Thr Ser 
            20                  25                  30          


Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Ile Pro Val Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Trp Arg Ser Ser Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     


<210>  30
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Gly Asp Trp Gly Leu Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  31
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Phe Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Lys Phe Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Asn Tyr Asp Ile Leu Thr Gly Tyr Ile Arg Pro Asp 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys 
225                 230 


<210>  32
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Ser Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Tyr Gly Asp Leu Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  33
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Arg Tyr Asp Phe Trp Ser Gly His Trp Tyr Phe 
            100                 105                 110         


Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys 
225             


<210>  34
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Glu Asn Asp Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Tyr Tyr Gly Ser Gly Ser Leu Phe Arg Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  35
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Ala Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ala Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 


<210>  36
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Ser Tyr Tyr Asp Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  37
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable heavy chain sequence

<400>  37

Ala Val Gln Gln Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  38

Asp Ile Val Met Thr His Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile His Thr Leu Ser His Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Ile Gln Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  39
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  39

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  40
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Thr Gln Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  41
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  41

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Arg Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln His Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Gly Asn Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  42
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  42

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Ser Ile Ser Ser Tyr 
            20                  25                  30          


Phe Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  43
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  43

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Val Gly His Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Asp Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  44
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  45
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  46
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  46

Gln Ala Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Asn 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu Gly Arg 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  47
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Arg Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  48
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Leu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  49
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  50
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  51
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  52
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  53
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  54
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  55
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  56
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  57
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  58
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  58

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  59
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Thr Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  60
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  60

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Arg Ser Lys 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Asn Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  61
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  62
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  63
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  64
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  65
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized variable light chain sequence

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Gly Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn His Trp Pro Pro 
                85                  90                  95      


Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  66
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Gly Arg Ser Gly Gly Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Ile Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Thr Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Arg Arg Pro Phe Asn Ser Tyr Asn Thr Glu Gln Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  67
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  67

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Val Ser Gly Ser Ile Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Thr Ser Gly Gly Lys Thr Val Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Thr Glu Asp Ala Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Ser Arg Ser Ser Trp Tyr Asp Glu Tyr Leu Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  68
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Arg Thr Phe Ser Val Tyr 
            20                  25                  30          


Gly Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ala Val Ser Ala Ser Gly Gly Tyr Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Ala Ala Pro Arg Trp Gly Gly Ala Thr Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  69

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Ser Ile Phe Ser Asp Gly 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Gly Gly Arg Thr Gly Tyr Ala Asp Phe Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Asn Leu Gln 
65                  70                  75                  80  


Met Asn Arg Leu Glu Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Thr 
                85                  90                  95      


Tyr Pro Phe Pro Ile Tyr Lys Lys Gly Tyr Pro Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  70

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Gly Arg Ser Gly Gly Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Ile Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Thr Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Arg Arg Pro Phe Asn Ser Tyr Asn Thr Glu Gln Ser Tyr Asp 
            100                 105                 110         


Ser Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  71
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  71

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Thr Ser Gly Gly Lys Thr Val Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Thr Glu Asp Ala Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asp Ser Arg Ser Ser Trp Tyr Asp Glu Tyr Leu Glu His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  72
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  72

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Ala Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Gly Gly Ile Arg Trp Ser Gly Gly Thr Thr Leu Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Val Ile Gly Gly Phe Gly Ala Phe Arg Ala His Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  73
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  73

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Met Ile Asn 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  74
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  74

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Thr Ser Ala Thr Ile Val Ser Ile Tyr 
            20                  25                  30          


Arg Ile Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Ser Gly Arg Thr Ile Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Ala Ser Thr Val Thr Ala Trp Pro Tyr Tyr Gly Pro Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  75
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  75

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe Ala Ile Tyr 
            20                  25                  30          


Asp Ile Ala Trp Tyr Arg His Pro Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Met Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  76
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  76

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Thr Met Ser Gly Arg Ser Leu Ser Ser Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Arg Gly Asp Gly Tyr Thr Asp Glu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Val Gly Pro Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Ala Val Gln Ala Val Ile Gly Gly Thr Leu Thr Thr Ala Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  77
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Thr Trp Ala Pro Thr Pro Thr Asn Arg Arg Ser Asp Tyr Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  78
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe Ala Ile Tyr 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ser Asn Ala Met Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  79
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  79

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ile Ala Asp Asn Arg Tyr Tyr Ala Asp Val Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Gly Arg Ser Arg Tyr Leu Tyr Gly Ser Ser Leu Asn Gly Pro 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  80
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  80

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe Ala Ile Tyr 
            20                  25                  30          


Asp Ile Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ser Asn Ala Met Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  81
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  81

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Met Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Arg Trp Ser Ser Gly Asn Thr Trp Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Asn Ile Tyr Tyr Thr Arg Arg Ala Pro Glu Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  82
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Arg Asn Ile Phe Pro Ile Asp 
            20                  25                  30          


Asp Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Val Thr Ser Gly Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Arg Arg Thr Ile Asp Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asp Arg Thr Leu Tyr Gly Lys Tyr Lys Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  83
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  83

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  84
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  84

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe Ala Ile Tyr 
            20                  25                  30          


Asp Ile Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ser Asn Ala Met Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  85
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  85

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Met Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Arg Trp Ser Ser Gly Asn Thr Trp Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Asn Ile Tyr Tyr Thr Arg Arg Ala Pro Glu Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  86
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Val Ser Trp Arg Tyr Asp Arg Thr Tyr Tyr Thr Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Asp Thr Asn Trp Arg Ala Gly Pro Arg Val Gly Ile Asp Glu 
            100                 105                 110         


Tyr Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  87
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Arg Asn Ile Phe Pro Ile Asp 
            20                  25                  30          


Asp Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Val Thr Ser Gly Gly Arg Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Arg Arg Thr Ile Asp Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asp Arg Thr Leu Tyr Gly Lys Tyr Lys Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  88
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - synthesized variable heavy chain

<400>  88

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  89
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  89

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
        35                  40                  45              


Phe Met Ile Asn Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln 
    50                  55                  60                  


Arg Glu Leu Val Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gln Thr Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
145                 150                 155                 160 


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Asn 
                165                 170                 175     


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
            180                 185                 190         


Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu Arg Phe 
        195                 200                 205             


Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    210                 215                 220                 


Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu Gly Arg 
225                 230                 235                 240 


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
                245                 250                 255     


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
            260                 265                 270         


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
        275                 280                 285             


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
    290                 295                 300                 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
                325                 330                 335     


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
            340                 345                 350         


Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360 


<210>  90
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  90

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile 
        35                  40                  45              


Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly Asn Gln 
    50                  55                  60                  


Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Met 
                85                  90                  95      


Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gln Thr Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
145                 150                 155                 160 


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Asn 
                165                 170                 175     


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
            180                 185                 190         


Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu Arg Phe 
        195                 200                 205             


Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    210                 215                 220                 


Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu Gly Arg 
225                 230                 235                 240 


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
                245                 250                 255     


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
            260                 265                 270         


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
        275                 280                 285             


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
    290                 295                 300                 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
                325                 330                 335     


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
            340                 345                 350         


Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360 


<210>  91
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  91

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Gly Thr 
        35                  40                  45              


Phe Ser Arg Tyr His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Phe Val Ser Ala Ile Thr Trp Ser Gly Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Thr Trp Ala Pro Thr Pro Thr Asn Arg Arg 
        115                 120                 125             


Ser Asp Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Ser Gln Thr Val Val Leu Gln Glu Pro Ser Leu Ser 
145                 150                 155                 160 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly 
                165                 170                 175     


Ser Val Ser Thr Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly 
            180                 185                 190         


Gln Ala Pro Arg Thr Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp 
        195                 200                 205             


Val Pro Glu Arg Phe Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu 
    210                 215                 220                 


Thr Ile Thr Gly Ala Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu 
225                 230                 235                 240 


Leu Tyr Leu Gly Arg Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            260                 265                 270         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        275                 280                 285             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    290                 295                 300                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
305                 310                 315                 320 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                325                 330                 335     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            340                 345                 350         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360                 365 


<210>  92
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  92

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile 
        35                  40                  45              


Phe Ala Ile Tyr Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln 
    50                  55                  60                  


Arg Glu Leu Val Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Ser Asn Ala Met 
                85                  90                  95      


Lys Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gln Thr Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
145                 150                 155                 160 


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Asn 
                165                 170                 175     


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
            180                 185                 190         


Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu Arg Phe 
        195                 200                 205             


Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    210                 215                 220                 


Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu Gly Arg 
225                 230                 235                 240 


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
                245                 250                 255     


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
            260                 265                 270         


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
        275                 280                 285             


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
    290                 295                 300                 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
                325                 330                 335     


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
            340                 345                 350         


Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360 


<210>  93
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  93

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile 
        35                  40                  45              


Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln 
    50                  55                  60                  


Arg Glu Leu Val Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Ser Asn Ala Met 
                85                  90                  95      


Lys Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gln Thr Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
145                 150                 155                 160 


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Asn 
                165                 170                 175     


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
            180                 185                 190         


Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu Arg Phe 
        195                 200                 205             


Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    210                 215                 220                 


Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu Gly Arg 
225                 230                 235                 240 


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
                245                 250                 255     


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
            260                 265                 270         


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
        275                 280                 285             


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
    290                 295                 300                 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
                325                 330                 335     


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
            340                 345                 350         


Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360 


<210>  94
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  94

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr 
        35                  40                  45              


Phe Ser Met Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Phe Val Ala Ser Ile Arg Trp Ser Ser Gly Asn Thr Trp Tyr 
65                  70                  75                  80  


Ala Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asn Ile Tyr Tyr Thr Arg Arg Ala Pro Glu 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Gly Ser Gln Thr Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser 
                165                 170                 175     


Thr Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro 
            180                 185                 190         


Arg Thr Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu 
        195                 200                 205             


Arg Phe Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu 
225                 230                 235                 240 


Gly Arg Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            260                 265                 270         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
        275                 280                 285             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
    290                 295                 300                 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
305                 310                 315                 320 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                325                 330                 335     


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
            340                 345                 350         


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360         


<210>  95
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  95

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr Tyr Gly 
        115                 120                 125             


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  96
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  96

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala Asn Ile 
        35                  40                  45              


Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
    50                  55                  60                  


Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys Tyr Ala 
65                  70                  75                  80  


Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Tyr Ala Arg Thr Gln Arg Met Gly Val Val Asn Ser Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
                165                 170                 175     


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
            180                 185                 190         


Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
        195                 200                 205             


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
            260                 265                 270         


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
        275                 280                 285             


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
    290                 295                 300                 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
                325                 330                 335     


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
            340                 345                 350         


Pro Thr Glu Cys Ser 
        355         


<210>  97
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  97

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala Asn Ile 
        35                  40                  45              


Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
    50                  55                  60                  


Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys Tyr Ala 
65                  70                  75                  80  


Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Asn Ala Val Thr Tyr Asp Gly Tyr Thr Ile Arg Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser Asp Ile Glu 
    130                 135                 140                 


Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser 
            180                 185                 190         


Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
        195                 200                 205             


Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
                245                 250                 255     


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
            260                 265                 270         


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
        275                 280                 285             


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
    290                 295                 300                 


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
305                 310                 315                 320 


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
                325                 330                 335     


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
            340                 345                 350         


Cys Ser 
        


<210>  98
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  98

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala Asn Ile 
        35                  40                  45              


Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
    50                  55                  60                  


Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gln Phe Arg Asn Asp Tyr Gly Leu Arg Tyr Gln 
        115                 120                 125             


Ser Thr Asn Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser 
145                 150                 155                 160 


Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile 
                165                 170                 175     


Gly Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            180                 185                 190         


Val Leu Val Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu 
        195                 200                 205             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    210                 215                 220                 


Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala 
225                 230                 235                 240 


Asn Thr Leu Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            260                 265                 270         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
        275                 280                 285             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
    290                 295                 300                 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
305                 310                 315                 320 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                325                 330                 335     


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
            340                 345                 350         


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360         


<210>  99
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  99

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala Asn Ile 
        35                  40                  45              


Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
    50                  55                  60                  


Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys Tyr Ala 
65                  70                  75                  80  


Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Asn Ala Asn Tyr Arg Gly Asn Arg Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser Asp Ile Glu Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
        195                 200                 205             


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val 
                245                 250                 255     


Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr 
            260                 265                 270         


Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala 
        275                 280                 285             


Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr 
    290                 295                 300                 


Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser 
305                 310                 315                 320 


Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val 
                325                 330                 335     


Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys 
            340                 345                 350         


Ser 
    


<210>  100
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  100

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile 
        35                  40                  45              


Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly Asn Gln 
    50                  55                  60                  


Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Met 
                85                  90                  95      


Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
                165                 170                 175     


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
            180                 185                 190         


Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
        195                 200                 205             


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
            260                 265                 270         


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
        275                 280                 285             


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
    290                 295                 300                 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
                325                 330                 335     


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
            340                 345                 350         


Pro Thr Glu Cys Ser 
        355         


<210>  101
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  101

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Gly Thr 
        35                  40                  45              


Phe Ser Arg Tyr His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Phe Val Ser Ala Ile Thr Trp Ser Gly Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Thr Trp Ala Pro Thr Pro Thr Asn Arg Arg 
        115                 120                 125             


Ser Asp Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser 
145                 150                 155                 160 


Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile 
                165                 170                 175     


Gly Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            180                 185                 190         


Val Leu Val Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu 
        195                 200                 205             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    210                 215                 220                 


Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala 
225                 230                 235                 240 


Asn Thr Leu Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            260                 265                 270         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
        275                 280                 285             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
    290                 295                 300                 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
305                 310                 315                 320 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                325                 330                 335     


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
            340                 345                 350         


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360         


<210>  102
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  102

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile 
        35                  40                  45              


Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln 
    50                  55                  60                  


Arg Glu Leu Val Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Ser Asn Ala Met 
                85                  90                  95      


Lys Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
                165                 170                 175     


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
            180                 185                 190         


Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
        195                 200                 205             


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
            260                 265                 270         


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
        275                 280                 285             


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
    290                 295                 300                 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
                325                 330                 335     


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
            340                 345                 350         


Pro Thr Glu Cys Ser 
        355         


<210>  103
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  103

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr 
        35                  40                  45              


Phe Ser Met Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Phe Val Ala Ser Ile Arg Trp Ser Ser Gly Asn Thr Trp Tyr 
65                  70                  75                  80  


Ala Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asn Ile Tyr Tyr Thr Arg Arg Ala Pro Glu 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
145                 150                 155                 160 


Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe 
                165                 170                 175     


Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
            180                 185                 190         


Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
        195                 200                 205             


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
    210                 215                 220                 


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu 
225                 230                 235                 240 


Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                245                 250                 255     


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            260                 265                 270         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        275                 280                 285             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
    290                 295                 300                 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
305                 310                 315                 320 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                325                 330                 335     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            340                 345                 350         


Val Ala Pro Thr Glu Cys Ser 
        355                 


<210>  104
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  104

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  105
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  105

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
145                 150                 155                 160 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
                165                 170                 175     


His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly 
            180                 185                 190         


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
225                 230                 235                 240 


Gln Gly Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
            260                 265                 270         


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
        275                 280                 285             


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
    290                 295                 300                 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
305                 310                 315                 320 


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
                325                 330                 335     


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
            340                 345                 350         


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360                 365 


<210>  106
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  106

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Asp Ile Val Met Thr His Thr Pro Leu Ser Leu Ser Val Thr 
145                 150                 155                 160 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu 
                165                 170                 175     


Asp Thr Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
            180                 185                 190         


Gly Gln Ser Pro Gln Leu Leu Ile His Thr Leu Ser His Arg Ala Ser 
        195                 200                 205             


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    210                 215                 220                 


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
225                 230                 235                 240 


Met Gln Ser Ile Gln Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            260                 265                 270         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        275                 280                 285             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
    290                 295                 300                 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
305                 310                 315                 320 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
                325                 330                 335     


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
            340                 345                 350         


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360                 365     


<210>  107
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  107

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Val Gly His Lys 
                165                 170                 175     


Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val 
            180                 185                 190         


Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro Val Arg Phe Ser 
        195                 200                 205             


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
    210                 215                 220                 


Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr 
225                 230                 235                 240 


Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
                245                 250                 255     


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
            260                 265                 270         


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
        275                 280                 285             


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
    290                 295                 300                 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
305                 310                 315                 320 


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
                325                 330                 335     


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
            340                 345                 350         


Val Ala Pro Thr Glu Cys Ser 
        355                 


<210>  108
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  108

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro 
145                 150                 155                 160 


Gly Gln Arg Val Thr Ile Ser Cys Thr Arg Ser Ser Ser Asn Ile Gly 
                165                 170                 175     


Ala Gly Tyr Asp Val His Trp Tyr Gln Gln His Pro Gly Thr Ala Pro 
            180                 185                 190         


Lys Leu Leu Ile Phe Gly Asn Ser Ile Arg Pro Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr 
    210                 215                 220                 


Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp 
225                 230                 235                 240 


Ser Ser Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                245                 250                 255     


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            260                 265                 270         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
        275                 280                 285             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
    290                 295                 300                 


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
305                 310                 315                 320 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                325                 330                 335     


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
            340                 345                 350         


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360             


<210>  109
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  109

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
145                 150                 155                 160 


Pro Gly Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly 
                165                 170                 175     


Thr Tyr Leu Thr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu 
            180                 185                 190         


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
    210                 215                 220                 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Thr Gln Phe 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  110
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  110

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Ser Ile Ser 
                165                 170                 175     


Ser Tyr Phe Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Thr Phe 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  111
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  111

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Gly Asn Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Phe Thr Gly Gly 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Met Leu Ile Thr Asp Ala 
        115                 120                 125             


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly His His His 
465                 470                 475                 480 


His His His 
            


<210>  112
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  112

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Gly Tyr Ser Trp Ser Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Tyr Tyr Asp Ile Leu Thr 
        115                 120                 125             


Gly Tyr Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser 
465                 470                 475                 480 


Gly His His His His His His 
                485         


<210>  113
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  113

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser 
465                 470                 475                 480 


Gly His His His His His His 
                485         


<210>  114
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  114

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln His 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Thr Tyr Gly Gly Asp Ala 
        115                 120                 125             


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly His His His 
465                 470                 475                 480 


His His His 
            


<210>  115
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  115

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ala Ile Ser Gly Thr Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Thr Gly Asn 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Val Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Asn Leu Asn Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Ile Gly Ile Ala Val Ala Ala 
        115                 120                 125             


Pro Val Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly His His 
465                 470                 475                 480 


His His His His 
                


<210>  116
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  116

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Lys Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Arg Asp Tyr Tyr Asp Ser 
        115                 120                 125             


Ser Gly Tyr Tyr Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
465                 470                 475                 480 


Ser Gly Ser Gly His His His His His His 
                485                 490 


<210>  117
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  117

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly Asp 
465                 470                 475                 480 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
                485                 490                 495     


Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe Ala Ile Tyr Asp 
            500                 505                 510         


Ile Ala Trp Tyr Arg His Pro Pro Gly Asn Gln Arg Glu Leu Val Ala 
        515                 520                 525             


Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr Ala Asp Ser Val Lys 
    530                 535                 540                 


Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Met Lys Thr Val Tyr Leu 
545                 550                 555                 560 


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                565                 570                 575     


Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp Gly Gln Gly Thr 
            580                 585                 590         


Gln Val Thr Val Ser Ser 
        595             


<210>  118
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  118

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln 
        195                 200                 205             


Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr 
    210                 215                 220                 


Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr Tyr Gly Met Asp 
                245                 250                 255     


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
            260                 265                 270         


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
        275                 280                 285             


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
    290                 295                 300                 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
305                 310                 315                 320 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
                325                 330                 335     


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
            340                 345                 350         


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
        355                 360                 365             


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    370                 375                 380                 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
385                 390                 395                 400 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                405                 410                 415     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            420                 425                 430         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        435                 440                 445             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    450                 455                 460                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
465                 470                 475                 480 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                485                 490                 495     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            500                 505                 510         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        515                 520                 525             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    530                 535                 540                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
545                 550                 555                 560 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                565                 570                 575     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            580                 585                 590         


Ser Leu Ser Pro Gly Lys 
        595             


<210>  119
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  119

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ala Val Val Leu Gln Glu Pro Ser Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser 
        35                  40                  45              


Gly Ser Val Ser Thr Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro 
    50                  55                  60                  


Gly Gln Ala Pro Arg Thr Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser 
65                  70                  75                  80  


Asp Val Pro Glu Arg Phe Ser Gly Ser Ile Val Gly Asn Lys Ala Ala 
                85                  90                  95      


Leu Thr Ile Thr Gly Ala Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys 
            100                 105                 110         


Leu Leu Tyr Leu Gly Arg Gly Ile Trp Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
                165                 170                 175     


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
            180                 185                 190         


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
        195                 200                 205             


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 
    210                 215                 220                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Gly Ser 
225                 230                 235                 240 


Gly Ser Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                245                 250                 255     


Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe 
            260                 265                 270         


Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly Asn Gln Arg 
        275                 280                 285             


Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr Ala 
    290                 295                 300                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Met Lys 
305                 310                 315                 320 


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
                325                 330                 335     


Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp 
            340                 345                 350         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360         


<210>  120
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  120

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Gln Ala Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser 
                165                 170                 175     


Thr Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro 
            180                 185                 190         


Arg Thr Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu 
        195                 200                 205             


Arg Phe Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu 
225                 230                 235                 240 


Gly Arg Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            260                 265                 270         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
        275                 280                 285             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
    290                 295                 300                 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
305                 310                 315                 320 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                325                 330                 335     


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
            340                 345                 350         


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360         


<210>  121

<400>  121
000

<210>  122
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  122

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly His His His His 
                245                 250                 255     


His His 
        


<210>  123
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  123

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr 
        35                  40                  45              


Phe Ser Met Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Phe Val Ala Ser Ile Arg Trp Ser Ser Gly Asn Thr Trp Tyr 
65                  70                  75                  80  


Ala Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Tyr Ala Asn Ile Tyr Tyr Thr Arg Arg Ala Pro Glu 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Gly Ser Gln Thr Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro 
145                 150                 155                 160 


Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser 
                165                 170                 175     


Thr Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro 
            180                 185                 190         


Arg Thr Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu 
        195                 200                 205             


Arg Phe Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu 
225                 230                 235                 240 


Gly Arg Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255     


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            260                 265                 270         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
        275                 280                 285             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
    290                 295                 300                 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
305                 310                 315                 320 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                325                 330                 335     


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
            340                 345                 350         


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360         


<210>  124
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  124

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr 
65                  70                  75                  80  


Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr Tyr Gly 
        115                 120                 125             


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Gly Ser Gly His His His His His His 
                245                 250                 


<210>  125
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  125

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ala Val Val Leu Gln Glu Pro Ser Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser 
        35                  40                  45              


Gly Ser Val Ser Thr Asn Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro 
    50                  55                  60                  


Gly Gln Ala Pro Arg Thr Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser 
65                  70                  75                  80  


Asp Val Pro Glu Arg Phe Ser Gly Ser Ile Val Gly Asn Lys Ala Ala 
                85                  90                  95      


Leu Thr Ile Thr Gly Ala Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys 
            100                 105                 110         


Leu Leu Tyr Leu Gly Arg Gly Ile Trp Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
                165                 170                 175     


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
            180                 185                 190         


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
        195                 200                 205             


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 
    210                 215                 220                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235             


<210>  126
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  126

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  127
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  127

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr 
    130                 135                 140                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
145                 150                 155                 160 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                165                 170                 175     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            180                 185                 190         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        195                 200                 205             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    210                 215                 220                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
225                 230                 235                 240 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                245                 250                 255     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            260                 265                 270         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys 
        275                 280                 285             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    290                 295                 300                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
305                 310                 315                 320 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                325                 330                 335     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            340                 345                 350         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365             


Gly Ser Gly Ser Gly His His His His His His 
    370                 375                 


<210>  128
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  128

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr 
    130                 135                 140                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
145                 150                 155                 160 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                165                 170                 175     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            180                 185                 190         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        195                 200                 205             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    210                 215                 220                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
225                 230                 235                 240 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                245                 250                 255     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            260                 265                 270         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        275                 280                 285             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    290                 295                 300                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
305                 310                 315                 320 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                325                 330                 335     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            340                 345                 350         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365             


Gly Gly Ser Gly Ser Ala Val Gln Gln Val Glu Ser Gly Gly Gly Leu 
    370                 375                 380                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
385                 390                 395                 400 


Thr Leu Asp Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
                405                 410                 415     


Lys Arg Glu Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn Tyr 
            420                 425                 430         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        435                 440                 445             


Asn Thr Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
    450                 455                 460                 


Val Tyr Phe Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp Gly 
465                 470                 475                 480 


Gln Gly Thr Gln Val Thr Val Ser Ser 
                485                 


<210>  129
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 004S-D01 Heavy Chain

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Gly Phe Gly Thr Val Val Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  130
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 004S-D01 Light Chain

<400>  130

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  131
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - 004S-E09 Heavy Chain

<400>  131

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ser Ala Tyr Asn Gly Tyr Lys Ser Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Gly Tyr Val Gly Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  132
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - 004S-E09 Light Chain

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  133
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 008S-D01 Heavy Chain

<400>  133

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala Asn Ile Asn Ser Ile Glu 
            20                  25                  30          


Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Ile 
        35                  40                  45              


Ala Asn Met Arg Gly Gly Gly Tyr Met Lys Tyr Ala Gly Ser Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Met Ser Thr Glu Ser Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr Arg Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  134
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  134

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala 
        35                  40                  45              


Asn Ile Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys 
65                  70                  75                  80  


Tyr Ala Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr 
        115                 120                 125             


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly 
    130                 135                 140                 


Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Val Gly His Lys Tyr Ala 
                165                 170                 175     


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
            180                 185                 190         


Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro Val Arg Phe Ser Gly Ser 
        195                 200                 205             


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Asp Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
            260                 265                 270         


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
        275                 280                 285             


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
    290                 295                 300                 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
                325                 330                 335     


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
            340                 345                 350         


Pro Thr Glu Cys Ser 
        355         


<210>  135
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  135

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Arg Ile Phe Ser Ile Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gly Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys 
145                 150                 155                 160 


Ser Gly Asp Lys Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro 
            180                 185                 190         


Ser Gly Ile Pro Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
        195                 200                 205             


Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gln Ala Trp Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
                245                 250                 255     


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
            260                 265                 270         


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
        275                 280                 285             


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
    290                 295                 300                 


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
305                 310                 315                 320 


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 
                325                 330                 335     


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            340                 345                 350     


<210>  136
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  136

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala 
        35                  40                  45              


Asn Ile Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys 
65                  70                  75                  80  


Tyr Ala Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr 
        115                 120                 125             


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
                165                 170                 175     


Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
225                 230                 235                 240 


Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 250                 255     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            260                 265                 270         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        275                 280                 285             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    290                 295                 300                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
305                 310                 315                 320 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                325                 330                 335     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            340                 345                 350         


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360     


<210>  137
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  137

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  138
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  138

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Arg Ile Phe Ser Ile Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gly Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Ser Gly Ser Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
            260                 265                 270         


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
        275                 280                 285             


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
    290                 295                 300                 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
305                 310                 315                 320 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
                325                 330                 335     


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 350         


<210>  139
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  139

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala 
        35                  40                  45              


Asn Ile Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys 
65                  70                  75                  80  


Tyr Ala Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr 
        115                 120                 125             


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly 
    130                 135                 140                 


Gln Ala Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
145                 150                 155                 160 


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Asn 
                165                 170                 175     


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
            180                 185                 190         


Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser Asp Val Pro Glu Arg Phe 
        195                 200                 205             


Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
    210                 215                 220                 


Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys Leu Leu Tyr Leu Gly Arg 
225                 230                 235                 240 


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
                245                 250                 255     


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
            260                 265                 270         


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
        275                 280                 285             


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
    290                 295                 300                 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
                325                 330                 335     


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
            340                 345                 350         


Thr Val Ala Pro Thr Glu Cys Ser 
        355                 360 


<210>  140
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  140

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Arg Ile Phe Ser Ile Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gly Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Ser Gly Ser Gly Gln Ala Val Val Leu Gln 
    130                 135                 140                 


Glu Pro Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
145                 150                 155                 160 


Gly Leu Ser Ser Gly Ser Val Ser Thr Asn Tyr Tyr Pro Ser Trp Tyr 
                165                 170                 175     


Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr Leu Ile Tyr Tyr Thr Asn 
            180                 185                 190         


Thr Arg Ser Ser Asp Val Pro Glu Arg Phe Ser Gly Ser Ile Val Gly 
        195                 200                 205             


Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Pro Asp Asp Glu Ser 
    210                 215                 220                 


Val Tyr Phe Cys Leu Leu Tyr Leu Gly Arg Gly Ile Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
                245                 250                 255     


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
            260                 265                 270         


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
        275                 280                 285             


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
    290                 295                 300                 


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
305                 310                 315                 320 


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
                325                 330                 335     


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
            340                 345                 350         


Cys Ser 
        


<210>  141
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  141

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala 
        35                  40                  45              


Asn Ile Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys 
65                  70                  75                  80  


Tyr Ala Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr 
        115                 120                 125             


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Ser 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
                165                 170                 175     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Asn Leu Leu Gly Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Trp 
225                 230                 235                 240 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
                245                 250                 255     


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
            260                 265                 270         


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
        275                 280                 285             


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
    290                 295                 300                 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
305                 310                 315                 320 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
                325                 330                 335     


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
            340                 345                 350         


Phe Asn Arg Gly Glu Cys 
        355             


<210>  142
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  142

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser 
                165                 170                 175     


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Asn Leu Leu Gly Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr 
225                 230                 235                 240 


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  143
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  143

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Arg Ile Phe Ser Ile Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gly Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Ser Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu 
            180                 185                 190         


Leu Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
            260                 265                 270         


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
        275                 280                 285             


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
    290                 295                 300                 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
305                 310                 315                 320 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
                325                 330                 335     


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 350         


<210>  144
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  144

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala 
        35                  40                  45              


Asn Ile Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys 
65                  70                  75                  80  


Tyr Ala Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr 
        115                 120                 125             


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Ser 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
                245                 250                 255     


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
            260                 265                 270         


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
        275                 280                 285             


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
    290                 295                 300                 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
305                 310                 315                 320 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
                325                 330                 335     


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
            340                 345                 350         


Phe Asn Arg Gly Glu Cys 
        355             


<210>  145
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  145

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser 
    130                 135                 140                 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  146
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  146

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Arg Ile Phe Ser Ile Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gly Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Ser Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
            260                 265                 270         


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
        275                 280                 285             


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
    290                 295                 300                 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
305                 310                 315                 320 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
                325                 330                 335     


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 350         


<210>  147
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  147

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala 
        35                  40                  45              


Asn Ile Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys 
65                  70                  75                  80  


Tyr Ala Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr 
        115                 120                 125             


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Ser 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
                245                 250                 255     


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
            260                 265                 270         


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
        275                 280                 285             


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
    290                 295                 300                 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
305                 310                 315                 320 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
                325                 330                 335     


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
            340                 345                 350         


Phe Asn Arg Gly Glu Cys 
        355             


<210>  148
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  148

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser 
    130                 135                 140                 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  149
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  149

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Arg Ile Phe Ser Ile Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gly Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Ser Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
            260                 265                 270         


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
        275                 280                 285             


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
    290                 295                 300                 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
305                 310                 315                 320 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
                325                 330                 335     


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 350         


<210>  150
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  150

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Ala 
        35                  40                  45              


Asn Ile Asn Ser Ile Glu Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Ile Ala Asn Met Arg Gly Gly Gly Tyr Met Lys 
65                  70                  75                  80  


Tyr Ala Gly Ser Leu Lys Gly Arg Phe Thr Met Ser Thr Glu Ser Ala 
                85                  90                  95      


Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr 
        115                 120                 125             


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Arg Thr Pro Phe 
225                 230                 235                 240 


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
                245                 250                 255     


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
            260                 265                 270         


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
        275                 280                 285             


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
    290                 295                 300                 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
305                 310                 315                 320 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
                325                 330                 335     


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
            340                 345                 350         


Phe Asn Arg Gly Glu Cys 
        355             


<210>  151
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  151

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Arg Thr 
225                 230                 235                 240 


Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  152
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  152

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Arg Ile Phe Ser Ile Tyr Asp Met Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Glu Arg Glu Phe Val Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gly Ser Arg Gly Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Ser Gly Ser Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Arg Thr Pro Phe Thr Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
            260                 265                 270         


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
        275                 280                 285             


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
    290                 295                 300                 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
305                 310                 315                 320 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
                325                 330                 335     


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 350         


<210>  153
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  153

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Leu Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Thr Tyr Arg Tyr Leu His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Gly 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Ser Met Val Arg Val Pro Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  154
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  154

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Phe Gly Ile Tyr Ser Met Thr Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr 
65                  70                  75                  80  


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Val Gly Pro Gly Gly Trp Phe Asp 
        115                 120                 125             


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  155
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  155

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Thr Gly Phe Gly Thr Val Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  156
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  156

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Tyr Ile Glu Asn Asp Gly Ser Ile Thr 
65                  70                  75                  80  


Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Pro Tyr Tyr Tyr Gly Ser Gly 
        115                 120                 125             


Ser Leu Phe Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  157
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized Wnt surrogate molecule

<400>  157

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Asn Phe Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr 
65                  70                  75                  80  


Lys Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Val Gly Glu Val Gly Ala Thr 
        115                 120                 125             


Met Leu Gly Ile Gly Val Trp Tyr Trp Phe Asp Pro Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  158

Ala Ser Phe Ser Gly His Tyr Trp Thr 
1               5                   


<210>  159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  159

Ala Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10      


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  160

Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10      


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  161

Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn 
1               5                   10      


<210>  162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  162

Asp Ser Val Ser Ser Asn Ser Gly Ala Trp Asn 
1               5                   10      


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  163

Asp Thr Phe Ser Asn Tyr Val Ile Ser 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  164

Asp Thr Phe Ser Asn Tyr Val Leu Ser 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  165

Phe Ala Phe Asp Asp Tyr Ala Met His 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  166

Phe Ala Phe Ser Ser His Trp Met His 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  167

Phe Ala Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  168

Phe Ala Val Ser Ser Ser Tyr Met Ser 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  169

Phe Phe Phe Ser Gly Tyr Trp Met Ser 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  170

Phe Ile Phe Ser Asp Tyr Tyr Met Ser 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  171

Phe Ile Phe Ser Glx Tyr Ala Met Ser 
1               5                   


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  172

Phe Asn Phe Gly Ile Tyr Ser Met Thr 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  173

Phe Asn Phe Ser Ser Tyr Thr Met Arg 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  174

Phe Asn Ile Arg Arg Glx Asn Met Glx 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  175

Phe Asn Leu Arg Arg Tyr Asn Met Asn 
1               5                   


<210>  176
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  176

Phe Pro Phe Ser Thr Phe Ser Met Asn 
1               5                   


<210>  177
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  177

Phe Arg Phe Ile Ser His Pro Ile His 
1               5                   


<210>  178
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  178

Phe Ser Phe Arg Ser Tyr Ser Met Ser 
1               5                   


<210>  179
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  179

Phe Ser Phe Ser Lys Lys Tyr Met Thr 
1               5                   


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  180

Phe Ser Phe Ser Arg Tyr Gly Met Ser 
1               5                   


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  181

Phe Ser Phe Ser Ser Thr Ala Met Ser 
1               5                   


<210>  182
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  182

Phe Ser Phe Ser Ser Tyr Gly Met His 
1               5                   


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  183

Phe Ser Phe Ser Ser Tyr Gly Met Ser 
1               5                   


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  184

Phe Ser Phe Ser Thr Tyr Thr Met Ser 
1               5                   


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  185

Phe Ser Leu Ser Ser Tyr Gly Met His 
1               5                   


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  186

Phe Ser Val Gly Ser Asn Tyr Met Thr 
1               5                   


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  187

Phe Ser Val Ser Ser Asn Tyr Met Asn 
1               5                   


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  188

Phe Thr Phe Ala Asp Tyr Gly Met His 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  189

Phe Thr Phe Ala Asn Tyr Ala Met His 
1               5                   


<210>  190
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  190

Phe Thr Phe Ala Asn Tyr Ala Met Asn 
1               5                   


<210>  191
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  191

Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  192

Phe Thr Phe Asp Asp Tyr Gly Met His 
1               5                   


<210>  193
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  193

Phe Thr Phe Asp Asp Tyr Tyr Met Asn 
1               5                   


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  194

Phe Thr Phe Asp His Asn Pro Met Asn 
1               5                   


<210>  195
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  195

Phe Thr Phe Gly Asn Tyr Asp Met Asn 
1               5                   


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  196

Phe Thr Phe Gly Thr Tyr Trp Val Thr 
1               5                   


<210>  197
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  197

Phe Thr Phe Asn Arg His Ala Leu Ser 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  198

Phe Thr Phe Arg Asp Tyr Ala Met Asn 
1               5                   


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  199

Phe Thr Phe Arg Glu Tyr Ala Met Thr 
1               5                   


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  200

Phe Thr Phe Arg Met Tyr Gly Met His 
1               5                   


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  201

Phe Thr Phe Arg Asn Ser Ala Met His 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  202

Phe Thr Phe Arg Ser Tyr Gly Met His 
1               5                   


<210>  203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  203

Phe Thr Phe Ser Asp Phe Gly Met Asn 
1               5                   


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  204

Phe Thr Phe Ser Asp His Tyr Met Asp 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  205

Phe Thr Phe Ser Asp His Tyr Met Ser 
1               5                   


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  206

Phe Thr Phe Ser Asp Ser Tyr Met Ser 
1               5                   


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  207

Phe Thr Phe Ser Asp Tyr Gly Met His 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  208

Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  209

Phe Thr Phe Ser Ile Tyr Gly Met His 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  210

Phe Thr Phe Ser Asn Ala Gln Met Ser 
1               5                   


<210>  211
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  211

Phe Thr Phe Ser Asn Ala Trp Met Ser 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  212

Phe Thr Phe Ser Asn His Tyr Met Ser 
1               5                   


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  213

Phe Thr Phe Ser Asn His Tyr Thr Ser 
1               5                   


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  214

Phe Thr Phe Ser Asn Ser Asp Met Asn 
1               5                   


<210>  215
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  215

Phe Thr Phe Ser Asn Tyr Ala Met His 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  216

Phe Thr Phe Ser Asn Tyr Ala Met Thr 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  217

Phe Thr Phe Ser Asn Tyr Gly Met His 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  218

Phe Thr Phe Ser Asn Tyr Tyr Thr Ser 
1               5                   


<210>  219
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  219

Phe Thr Phe Ser Arg Tyr Ala Met His 
1               5                   


<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  220

Phe Thr Phe Ser Arg Tyr Ala Met Ser 
1               5                   


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  221

Phe Thr Phe Ser Ser Phe Gly Met His 
1               5                   


<210>  222
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  222

Phe Thr Phe Ser Ser His Ser Thr His 
1               5                   


<210>  223
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  223

Phe Thr Phe Ser Ser Asn Ala Met His 
1               5                   


<210>  224
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  224

Phe Thr Phe Ser Ser Ser Ala Met His 
1               5                   


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  225

Phe Thr Phe Ser Ser Ser Asn Met Asn 
1               5                   


<210>  226
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  226

Phe Thr Phe Ser Ser Ser Trp Met His 
1               5                   


<210>  227
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  227

Phe Thr Phe Ser Ser Tyr Ala Met His 
1               5                   


<210>  228
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  228

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  229
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  229

Phe Thr Phe Ser Ser Tyr Asp Met Asn 
1               5                   


<210>  230
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  230

Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   


<210>  231
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  231

Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  232

Phe Thr Phe Ser Ser Tyr Asn Met Asn 
1               5                   


<210>  233
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  233

Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210>  234
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  234

Phe Thr Phe Ser Ser Tyr Ser Met Ser 
1               5                   


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  235

Phe Thr Phe Ser Ser Tyr Thr Met Asn 
1               5                   


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  236

Phe Thr Phe Ser Ser Tyr Thr Met Ser 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  237

Phe Thr Phe Ser Ser Tyr Val Met Ser 
1               5                   


<210>  238
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  238

Phe Thr Phe Ser Ser Tyr Trp Ile His 
1               5                   


<210>  239
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  239

Phe Thr Phe Ser Ser Tyr Trp Met His 
1               5                   


<210>  240
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  240

Phe Thr Phe Ser Ser Glx Glx Met His 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  241

Phe Thr Phe Ser Thr Xaa Trp Met Ser 
1               5                   


<210>  242
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  242

Phe Thr Phe Ser Thr Tyr Ala Met His 
1               5                   


<210>  243
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  243

Phe Thr Phe Ser Thr Tyr Glu Met Asn 
1               5                   


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  244

Phe Thr Phe Ser Thr Tyr Gly Met His 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  245

Phe Thr Phe Ser Thr Tyr Ser Met Ile 
1               5                   


<210>  246
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  246

Phe Thr Phe Ser Thr Tyr Ser Met Ser 
1               5                   


<210>  247
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  247

Phe Thr Phe Thr Gly Ser Ala Val Gln 
1               5                   


<210>  248
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  248

Phe Thr Phe Thr Asn Tyr Ala Met Ser 
1               5                   


<210>  249
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  249

Phe Thr Phe Thr Ser Ser Ala Met Gln 
1               5                   


<210>  250
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  250

Phe Thr Phe Thr Ser Ser Ala Thr Gln 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  251

Phe Thr Phe Thr Ser Ser Ala Val Gln 
1               5                   


<210>  252
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  252

Phe Thr Phe Thr Ser Tyr Ala Met His 
1               5                   


<210>  253
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  253

Phe Thr Phe Thr Glx Ser Ala Val Gln 
1               5                   


<210>  254
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  254

Phe Thr Phe Glx Glx Ser Glx Val Gln 
1               5                   


<210>  255
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  255

Phe Thr Leu Asp Tyr Tyr Ala Ile Ser 
1               5                   


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  256

Phe Thr Leu Ser Ser His His Met Asn 
1               5                   


<210>  257
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  257

Phe Thr Leu Ser Thr Tyr Asn Met Asn 
1               5                   


<210>  258
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  258

Phe Thr Val Gly Asn Asn Tyr Met Ser 
1               5                   


<210>  259
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  259

Phe Thr Val Gly Ser Trp Tyr Met Ser 
1               5                   


<210>  260
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  260

Phe Thr Val Ser Ser His Ser Met Gly 
1               5                   


<210>  261
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  261

Phe Thr Val Ser Ser Asn Tyr Met Asn 
1               5                   


<210>  262
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  262

Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  263
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  263

Phe Thr Glx Ser Ser Tyr Asp Met His 
1               5                   


<210>  264
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  264

Phe Thr Glx Ser Ser Tyr Ser Met Asn 
1               5                   


<210>  265
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  265

Gly Ala Phe Ser Thr Ser Ser Ile Ser 
1               5                   


<210>  266
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  266

Gly Ala Ile Ser Gly Thr Ser Tyr Phe Trp Gly 
1               5                   10      


<210>  267
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  267

Gly Asp Phe Thr Asn Tyr Ala Met Ala 
1               5                   


<210>  268
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  268

Gly Phe Phe Ser Ser Phe Thr Met Gly 
1               5                   


<210>  269
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  269

Gly Phe Thr Phe Ser Asp His Tyr 
1               5               


<210>  270
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  270

Gly Phe Thr Phe Ser His Tyr Thr Leu Ser 
1               5                   10  


<210>  271
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  271

Gly Asn Phe Lys Asn Tyr Gly Ile Thr 
1               5                   


<210>  272
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  272

Gly Pro Phe Asn Leu Phe Ala Met Gly 
1               5                   


<210>  273
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  273

Gly Pro Phe Asn Leu Leu Ala Met Gly 
1               5                   


<210>  274
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  274

Gly Ser Phe Ser Gly Tyr Ala Ile Asn 
1               5                   


<210>  275
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  275

Gly Ser Phe Ser Gly Tyr Ala Ile Ser 
1               5                   


<210>  276
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  276

Gly Ser Phe Ser Gly Tyr Tyr Trp His 
1               5                   


<210>  277
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  277

Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 
1               5                   


<210>  278
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  278

Gly Ser Phe Ser Asn Tyr Ala Ile Ser 
1               5                   


<210>  279
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  279

Gly Ser Phe Ser Thr Ser Val Phe Gly 
1               5                   


<210>  280
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  280

Gly Ser Ile Ser Gly Asn Asn Tyr Tyr Trp Gly 
1               5                   10      


<210>  281
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  281

Gly Ser Ile Ser Gly Asn Asn Tyr Tyr Glx Gly 
1               5                   10      


<210>  282
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  282

Gly Ser Ile Ser Asn Tyr Tyr Trp Ser 
1               5                   


<210>  283
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  283

Gly Ser Ile Ser Ser Gly Gly Tyr Ser Trp Ser 
1               5                   10      


<210>  284
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  284

Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10      


<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  285

Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly 
1               5                   10      


<210>  286
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  286

Gly Thr Phe Gly Asn Tyr Gly Ile Asn 
1               5                   


<210>  287
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  287

Gly Thr Phe Gly Ser Tyr Ala Ile Thr 
1               5                   


<210>  288
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  288

Gly Thr Phe Gly Ser Tyr Ala Val Gly 
1               5                   


<210>  289
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  289

Gly Thr Phe Asn Arg Tyr Ala Ile Thr 
1               5                   


<210>  290
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  290

Gly Thr Phe Asn Arg Tyr Gly Ile Ser 
1               5                   


<210>  291
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  291

Gly Thr Phe Asn Ser Tyr Ala Ile Ala 
1               5                   


<210>  292
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  292

Gly Thr Phe Arg Ser Tyr Ala Ile Asn 
1               5                   


<210>  293
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  293

Gly Thr Phe Ser Ser Asn Val Ile Ser 
1               5                   


<210>  294
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  294

Gly Thr Phe Ser Ser Tyr Ala Ile Asn 
1               5                   


<210>  295
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  295

Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210>  296
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  296

Gly Thr Phe Ser Ser Tyr Thr Ile Ser 
1               5                   


<210>  297
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  297

Gly Thr Phe Ser Ser Tyr Val Ile Ser 
1               5                   


<210>  298
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  298

Gly Thr Phe Ser Thr Tyr Ala Ile Ser 
1               5                   


<210>  299
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  299

Gly Thr Phe Ser Thr Tyr Ala Ile Ser 
1               5                   


<210>  300
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  300

Gly Thr Phe Ser Thr Tyr Ala Met Gly 
1               5                   


<210>  301
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  301

Gly Thr Phe Ser Glx Tyr Ala Ile Ser 
1               5                   


<210>  302
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  302

Gly Thr Phe Ser Glx Glx Thr Ile Ser 
1               5                   


<210>  303
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  303

Gly Thr Phe Thr Asn Asn Phe Met His 
1               5                   


<210>  304
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  304

Gly Thr Phe Thr Arg Asn Ser Ile Ser 
1               5                   


<210>  305
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  305

Gly Thr Phe Thr Ser Tyr Ala Ile Ser 
1               5                   


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  306

Gly Thr Phe Thr Ser Tyr Pro Ile Ser 
1               5                   


<210>  307
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  307

Gly Thr Phe Thr Tyr Arg Tyr Leu His 
1               5                   


<210>  308
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  308

Gly Thr Leu Asn Asn His Thr Leu Ser 
1               5                   


<210>  309
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  309

Gly Thr Ser Ser Thr Tyr Ala Met Gly 
1               5                   


<210>  310
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  310

His Asp Phe Ser Ser Thr Tyr Gly Val Gly 
1               5                   10  


<210>  311
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  311

His Asp Phe Ser Ser Thr Tyr Gly Val Gly 
1               5                   10  


<210>  312
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  312

His Thr Phe Ser Gly Tyr His Ile His 
1               5                   


<210>  313
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  313

Ile Ile Phe Ser Pro Asn Asp Met Gly 
1               5                   


<210>  314
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  314

Ile Lys Ser Met Phe Asp Met Asn Phe Met Gly 
1               5                   10      


<210>  315
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  315

Ile Thr Phe Gly Phe Asp Ser Val Gly 
1               5                   


<210>  316
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  316

Ile Thr Phe Ser Phe Asn Ser Val Gly 
1               5                   


<210>  317
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  317

Leu Ala Phe Asn Gly Tyr Thr Met Gly 
1               5                   


<210>  318
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  318

Leu Ala Ile Asp Asp Tyr Tyr Met Val 
1               5                   


<210>  319
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  319

Leu Thr Phe Ser Asp Tyr Thr Val Gly 
1               5                   


<210>  320
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  320

Leu Thr Phe Ser Ile Tyr Ala Met His 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  321

Leu Thr Phe Ser Thr Tyr Gly Met Gly 
1               5                   


<210>  322
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  322

Leu Thr Ile Asp Asp Tyr Tyr Met Val 
1               5                   


<210>  323
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  323

Leu Thr Ile Asp Asp Tyr Tyr Val Val 
1               5                   


<210>  324
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  324

Leu Thr Val Ser Thr Asn Phe Met Ser 
1               5                   


<210>  325
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  325

Asn Phe Phe Ser Asn Tyr Pro Leu Gly 
1               5                   


<210>  326
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  326

Asn Ile Phe Arg Ile Tyr Ala Ile Ala 
1               5                   


<210>  327
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  327

Gln Thr Phe Thr Ala Tyr Ala Met Gly 
1               5                   


<210>  328
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  328

Arg Ala Phe Ser Asn Tyr Ala Met Gly 
1               5                   


<210>  329
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  329

Arg Ala Phe Thr Asp Asn Val Met Ala 
1               5                   


<210>  330
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  330

Arg Ile Phe Ser Ser Tyr Ala Gln Ala 
1               5                   


<210>  331
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  331

Arg Met Phe Ser Asn Tyr Ala Met Gly 
1               5                   


<210>  332
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  332

Arg Arg Phe Thr Thr Tyr Gly Met Gly 
1               5                   


<210>  333
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  333

Arg Ser Phe Arg Thr Asn Ala Leu Gly 
1               5                   


<210>  334
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  334

Arg Ser Phe Ser Ile Tyr Asn Thr Ala 
1               5                   


<210>  335
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  335

Arg Ser Phe Ser Asn Tyr Arg Val Ala 
1               5                   


<210>  336
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  336

Arg Ser Phe Ser Thr Tyr Pro Met Gly 
1               5                   


<210>  337
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  337

Arg Thr Asp Gly Gly Tyr Val Met Gly 
1               5                   


<210>  338
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  338

Arg Thr Asp Gly Met Gln Ala Met Gly 
1               5                   


<210>  339
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  339

Arg Thr Phe Gly Ser Tyr Ala Met Gly 
1               5                   


<210>  340
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  340

Arg Thr Phe Gly Thr Trp Ala Met Gly 
1               5                   


<210>  341
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  341

Arg Thr Phe Asn Arg His Val Met Gly 
1               5                   


<210>  342
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  342

Arg Thr Phe Arg Ala Tyr Ala Met Gly 
1               5                   


<210>  343
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  343

Arg Thr Phe Ser Glu Tyr Ala Met Gly 
1               5                   


<210>  344
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  344

Arg Thr Phe Ser Asn Tyr Val Met Gly 
1               5                   


<210>  345
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  345

Arg Thr Phe Ser Ser Ala Ala Met Gly 
1               5                   


<210>  346
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  346

Arg Thr Phe Ser Ser Phe Val Met Gly 
1               5                   


<210>  347
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  347

Arg Thr Phe Ser Ser Tyr Ala Met Gly 
1               5                   


<210>  348
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  348

Arg Thr Phe Ser Ser Tyr Ser Leu Ala 
1               5                   


<210>  349
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  349

Arg Thr Phe Ser Thr Tyr Gly Met Gly 
1               5                   


<210>  350
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  350

Arg Thr Phe Ser Trp Tyr Ser Met Gly 
1               5                   


<210>  351
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  351

Arg Thr Leu Ser Ser Tyr Val Val Gly 
1               5                   


<210>  352
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  352

Arg Thr Ser Asp Leu Tyr Thr Met Gly 
1               5                   


<210>  353
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  353

Arg Thr Ser Ser Ser Tyr Ala Met Gly 
1               5                   


<210>  354
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  354

Arg Val Phe Ser Ser Tyr Ala Gln Ala 
1               5                   


<210>  355
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  355

Ser Ala Phe Ser Asn Tyr Ala Met Gly 
1               5                   


<210>  356
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  356

Ser Ile Asp Ser Ile Asn Ala Met Ala 
1               5                   


<210>  357
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  357

Ser Ile Phe Ser Ile Asn Ala Met Gly 
1               5                   


<210>  358
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  358

Ser Ile Phe Ser Ile Tyr Ala Met Gly 
1               5                   


<210>  359
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  359

Ser Ile Phe Ser Ser Asn Thr Ile Tyr 
1               5                   


<210>  360
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  360

Ser Leu Phe Arg Leu Asn Gly Met Gly 
1               5                   


<210>  361
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  361

Ser Thr Phe Ser Asn Tyr Ala Met Gly 
1               5                   


<210>  362
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  362

Ser Thr Phe Ser Thr Tyr Ala Met Gly 
1               5                   


<210>  363
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  363

Ser Thr Phe Thr Asn Ala Trp Met Ser 
1               5                   


<210>  364
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  364

Ser Val Val Asn Phe Val Val Met Gly 
1               5                   


<210>  365
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  365

Thr Thr Leu Asn Lys Tyr Ala Ile Ser 
1               5                   


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  366

Val Ser Phe Ser Gly Tyr Ala Met His 
1               5                   


<210>  367
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  367

Tyr Asp Phe Thr Thr Tyr Gly Ile His 
1               5                   


<210>  368
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  368

Tyr Ile Phe Thr Asp Tyr Tyr Met His 
1               5                   


<210>  369
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  369

Tyr Ile Phe Thr Gly Tyr Tyr Met His 
1               5                   


<210>  370
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  370

Tyr Ser Phe Thr Asn Tyr Ala Met His 
1               5                   


<210>  371
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  371

Tyr Ser Phe Thr Thr Tyr Gly Met Asn 
1               5                   


<210>  372
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  372

Tyr Thr Phe Ala Ser Tyr Asp Ile His 
1               5                   


<210>  373
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  373

Tyr Thr Phe Ala Ser Tyr Gly Met His 
1               5                   


<210>  374
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  374

Tyr Thr Phe Ser Gly Tyr Tyr Leu His 
1               5                   


<210>  375
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  375

Tyr Thr Phe Thr Asp Tyr His Met His 
1               5                   


<210>  376
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  376

Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   


<210>  377
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  377

Tyr Thr Phe Thr Gly His Tyr Ile His 
1               5                   


<210>  378
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  378

Tyr Thr Phe Thr Gly His Tyr Met His 
1               5                   


<210>  379
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  379

Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   


<210>  380
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  380

Tyr Thr Phe Thr His Ser Tyr Ile His 
1               5                   


<210>  381
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  381

Tyr Thr Phe Thr Lys Asp Tyr Met His 
1               5                   


<210>  382
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  382

Tyr Thr Phe Thr Asn His Phe Met His 
1               5                   


<210>  383
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  383

Tyr Thr Phe Thr Asn Asn Phe Met His 
1               5                   


<210>  384
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  384

Tyr Thr Phe Thr Asn Tyr Cys Thr Arg 
1               5                   


<210>  385
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  385

Tyr Thr Phe Thr Arg Tyr Ala Val His 
1               5                   


<210>  386
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  386

Tyr Thr Phe Thr Ser His Trp Met His 
1               5                   


<210>  387
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  387

Tyr Thr Phe Thr Ser Ser Ala Ile His 
1               5                   


<210>  388
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  388

Tyr Thr Phe Thr Ser Tyr Ala Ile Ser 
1               5                   


<210>  389
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  389

Tyr Thr Phe Thr Ser Tyr Ala Met His 
1               5                   


<210>  390
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  390

Tyr Thr Phe Thr Ser Tyr Asp Ile Asn 
1               5                   


<210>  391
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  391

Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   


<210>  392
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  392

Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   


<210>  393
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  393

Tyr Thr Phe Thr Thr Tyr Phe Met His 
1               5                   


<210>  394
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  394

Tyr Thr Phe Thr Tyr Arg Tyr Leu His 
1               5                   


<210>  395
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  395

Tyr Thr Phe Thr Tyr Tyr Ala Met His 
1               5                   


<210>  396
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  396

Tyr Thr Ile Thr Thr Tyr Ala Ile His 
1               5                   


<210>  397
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  397

Tyr Thr Leu Ser Asn Tyr Gly Ile Ser 
1               5                   


<210>  398
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  398

Tyr Thr Leu Thr Thr Trp Tyr Met Xaa 
1               5                   


<210>  399
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  399

Tyr Thr Val Thr Ser Tyr Ala Met His 
1               5                   


<210>  400
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  400

Tyr Glx Phe Glx Glx Glx Tyr Met His 
1               5                   


<210>  401
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  401

Glx Ser Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  402
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  402

Glx Thr Phe Ser Glx Tyr Asp Met His 
1               5                   


<210>  403
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  403

Glx Glx Glx Thr Asp Tyr Tyr Glx Gln 
1               5                   


<210>  404
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  404

Ala Ala Ile Gly Tyr Lys Val Lys Trp Asn Gly Glu Arg Thr Tyr Tyr 
1               5                   10                  15      


Leu 
    


<210>  405
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  405

Ala Ala Ile Asn Arg Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  406
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  406

Ala Ala Ile Asn Trp Ser Gly Asp Ser Ala Tyr Tyr Ala 
1               5                   10              


<210>  407
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  407

Ala Ala Ile Asn Trp Ser Gly Arg Ser Thr Val Tyr Ala 
1               5                   10              


<210>  408
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  408

Ala Ala Ile Ser Gly Ser Gly Glu Asn Thr Tyr Tyr Ala 
1               5                   10              


<210>  409
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  409

Ala Ala Ile Ser Arg Asn Gly Val Tyr Thr Arg Phe Ala 
1               5                   10              


<210>  410
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  410

Ala Ala Ile Ser Ser Gly Gly Ser Gly Thr Tyr Tyr Ser 
1               5                   10              


<210>  411
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  411

Ala Ala Ile Ser Trp Gly Gly Gly Ser Thr Phe Tyr Ser 
1               5                   10              


<210>  412
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  412

Ala Ala Ile Ser Trp Met Ser Asn Thr Tyr Tyr Ala 
1               5                   10          


<210>  413
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  413

Ala Ala Ile Ser Trp Arg Gly Thr Asn Ile Ala 
1               5                   10      


<210>  414
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  414

Ala Ala Ile Ser Trp Ser Asp Asn Thr Tyr Tyr Ala 
1               5                   10          


<210>  415
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  415

Ala Ala Ile Ser Trp Ser Gly Asp Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  416
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  416

Ala Ala Ile Ser Trp Ser Gly Asp Ser Thr Tyr Tyr Leu 
1               5                   10              


<210>  417
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  417

Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr His Tyr Ala 
1               5                   10              


<210>  418
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  418

Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  419
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  419

Ala Ala Ile Ser Trp Ser Gly Arg Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  420
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  420

Ala Ala Ile Ser Trp Ser Gly Ser Ala Thr His Tyr Ala 
1               5                   10              


<210>  421
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  421

Ala Ala Ile Ser Trp Ser Gly Ser Thr Ala Tyr Tyr Ala 
1               5                   10              


<210>  422
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  422

Ala Ala Ile Ser Trp Thr Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  423
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  423

Ala Ala Ile Ser Tyr Asp Glu Ser Asn Lys Phe Tyr Ala 
1               5                   10              


<210>  424
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  424

Ala Ala Ile Ser Tyr Asn Gly Phe Ser Thr Tyr Tyr Ser 
1               5                   10              


<210>  425
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  425

Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala 
1               5                   10          


<210>  426
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  426

Ala Ala Ile Thr Trp Ser Gly Ala Arg Thr Tyr Tyr Ala 
1               5                   10              


<210>  427
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  427

Ala Ala Leu Thr Gly Gln Arg Thr Thr Asn Tyr Ala 
1               5                   10          


<210>  428
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  428

Ala Ala Leu Thr Ser Gly Gly Ile Thr Tyr His Ala 
1               5                   10          


<210>  429
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  429

Ala Ala Val Asn Trp Arg Gly Asp Gly Thr Tyr Tyr Ser 
1               5                   10              


<210>  430
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  430

Ala Ala Val Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  431
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  431

Ala Ala Val Ser Ala Ser Gly Ala Asn Thr Tyr Tyr Ala 
1               5                   10              


<210>  432
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  432

Ala Ala Val Ser Ala Ser Gly Gly Tyr Thr Trp Tyr Ala 
1               5                   10              


<210>  433
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  433

Ala Ala Val Ser Trp Ser Gly Val Ser Thr Tyr Tyr Pro 
1               5                   10              


<210>  434
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  434

Ala Ala Val Thr Ala Ser Gly Gly Tyr Ala Trp Tyr Ala 
1               5                   10              


<210>  435
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  435

Ala Ala Val Thr Trp Arg Ala Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  436
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  436

Ala Ala Val Thr Trp Arg Ser Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  437
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  437

Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala 
1               5                   10          


<210>  438
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  438

Ala Phe Ile Thr Arg Gly Gly Thr Thr Arg Tyr Gly 
1               5                   10          


<210>  439
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  439

Ala Gly Ile Ala Ser Asp Ser Thr Thr Phe Tyr Ala 
1               5                   10          


<210>  440
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  440

Ala Gly Ile Gly Trp Asp Ser Thr Asn Ile Gly Tyr Ala 
1               5                   10              


<210>  441
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  441

Ala Gly Ile Asn Trp Asn Gly Gly Ser Val Val Tyr Ala 
1               5                   10              


<210>  442
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  442

Ala Gly Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  443
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  443

Ala Gly Ile Ser Gly Gly Gly Gly Ser Thr Asp Tyr Ala 
1               5                   10              


<210>  444
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  444

Ala Gly Ile Ser Gly Ser Gly Lys Thr Thr Phe Tyr Ala 
1               5                   10              


<210>  445
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  445

Ala Gly Ile Ser Arg Thr Gly Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  446
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  446

Ala Gly Ile Ser Trp Asn Ser Gly Thr Ile Asp Tyr Ala 
1               5                   10              


<210>  447
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  447

Ala Gly Val Ser Ile Asp Ala Asn Lys Lys Tyr Tyr Ala 
1               5                   10              


<210>  448
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  448

Ala Ile Val Ser Tyr Asp Gly Thr Tyr Lys Tyr Tyr Ser 
1               5                   10              


<210>  449
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  449

Ala Leu Ile Ser Leu Ser Gly Ala Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  450
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  450

Ala Leu Ile Ser Ser Gly Gly Ser Thr Ser Tyr Ala 
1               5                   10          


<210>  451
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  451

Ala Leu Ile Ser Ser Asn Gly Asp His Lys Tyr Tyr Thr 
1               5                   10              


<210>  452
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  452

Ala Leu Ile Ser Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala 
1               5                   10              


<210>  453
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  453

Ala Leu Ile Ser Tyr Asp Gly Gly Thr Lys Tyr Tyr Ala 
1               5                   10              


<210>  454
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  454

Ala Leu Ile Ser Tyr Asp Gly Ser His Thr Tyr Tyr Ala 
1               5                   10              


<210>  455
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  455

Ala Leu Ile Thr Thr Ser Gly Asn Thr Asn Tyr Ala 
1               5                   10          


<210>  456
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  456

Ala Leu Met Ser Pro Asp Gly Thr Ile Ile Tyr Tyr Ala 
1               5                   10              


<210>  457
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  457

Ala Leu Thr Ser Tyr Asp Gly Ser Lys Lys Phe Tyr Ala 
1               5                   10              


<210>  458
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  458

Ala Leu Val Gly Tyr Asp Gly Ser Gln Gln Phe Tyr Gly 
1               5                   10              


<210>  459
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  459

Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val 
1               5                   10              


<210>  460
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  460

Ala Gln Ile Ser Trp Thr Gly Gly Ser Thr Asp Tyr Ala 
1               5                   10              


<210>  461
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  461

Ala Ser Ile Pro Ser Asp Gly Thr Thr Phe Tyr Ala 
1               5                   10          


<210>  462
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  462

Ala Ser Ile Thr Trp Asn Gly Arg Tyr Thr Tyr Tyr Ala 
1               5                   10              


<210>  463
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  463

Ala Ser Ile Trp Phe Asp Gly Ser Asn Gln Asp Tyr Ala 
1               5                   10              


<210>  464
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  464

Ala Ser Ser Thr Gly Gly Gly Val Phe Glu Asn Tyr Ala 
1               5                   10              


<210>  465
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  465

Ala Thr Ile Gln Ser Gly Gly Arg Thr Asn Tyr Ala 
1               5                   10          


<210>  466
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  466

Ala Thr Ile Ser Gly Gly Gly Gly Ser Thr Phe Asp Asp 
1               5                   10              


<210>  467
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  467

Ala Thr Ile Ser Thr Arg Gly Thr Thr His Tyr Ala 
1               5                   10          


<210>  468
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  468

Ala Thr Ile Ser Trp Gly Gly Thr Asn Ile Ala 
1               5                   10      


<210>  469
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  469

Ala Thr Val Thr Trp Arg Thr Gly Thr Thr Tyr Tyr Ala 
1               5                   10              


<210>  470
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  470

Ala Val Phe Ile Ala Gly Tyr Gly Ala Tyr Tyr Ala 
1               5                   10          


<210>  471
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  471

Ala Val Phe Asn Ala Gly Tyr Arg Ala Tyr Tyr Ala 
1               5                   10          


<210>  472
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  472

Ala Val Ile Ser Arg Ser Gly Gly Asn Thr Tyr Tyr Thr 
1               5                   10              


<210>  473
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  473

Ala Val Ile Ser Ser Asp Gly Asn Asn Lys Tyr Tyr Thr 
1               5                   10              


<210>  474
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  474

Ala Val Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala 
1               5                   10              


<210>  475
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  475

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
1               5                   10              


<210>  476
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  476

Ala Val Ile Ser Tyr Asp Gly Ser Asn Arg Glx Tyr Ala 
1               5                   10              


<210>  477
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  477

Ala Val Ile Thr Ser Gly Gly Thr Phe Lys Tyr Tyr Ala 
1               5                   10              


<210>  478
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  478

Ala Val Met Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala 
1               5                   10          


<210>  479
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  479

Ala Val Ser Trp Ser Val Gly Met Thr Tyr Tyr Ala 
1               5                   10          


<210>  480
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  480

Ala Val Thr Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
1               5                   10              


<210>  481
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  481

Ala Val Val Ala Thr Gly Gly Ala Thr Asn Tyr Ala 
1               5                   10          


<210>  482
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  482

Ala Tyr Ile Asn Ser Gly Ser Ser Glu Met Asn Tyr Ala 
1               5                   10              


<210>  483
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  483

Ala Tyr Ile Asn Ser Arg Gly Ser Leu Met Tyr Tyr Ala 
1               5                   10              


<210>  484
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  484

Gly Ala Ile Ser Arg Thr Gly Ser Gly Thr Phe Tyr Ala 
1               5                   10              


<210>  485
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  485

Gly Ala Ile Thr Trp Ser Leu Gly Ile Ala Phe Tyr Ala 
1               5                   10              


<210>  486
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  486

Gly Ala Ile Thr Trp Ser Leu Gly Ser Ala Phe Tyr Ala 
1               5                   10              


<210>  487
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  487

Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Glu 
1               5                   10          


<210>  488
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  488

Gly Glu Ile Asp Arg Ser Gly Asp Thr Asn Tyr Asn 
1               5                   10          


<210>  489
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  489

Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn 
1               5                   10          


<210>  490
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  490

Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala 
1               5                   10                  15  


<210>  491
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  491

Gly Phe Ile Arg Ser Lys Asp Tyr Gly Gly Thr Thr Glu Tyr Ala 
1               5                   10                  15  


<210>  492
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  492

Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala 
1               5                   10              


<210>  493
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  493

Gly Gly Ile Phe Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  494
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  494

Gly Gly Ile Phe Pro Ile Tyr Gly Ile Ser Thr Tyr Ala 
1               5                   10              


<210>  495
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  495

Gly Gly Ile Ile Pro Phe Phe Asn Thr Val Asn Tyr Ala 
1               5                   10              


<210>  496
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  496

Gly Gly Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala 
1               5                   10              


<210>  497
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  497

Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Lys Tyr Ala 
1               5                   10              


<210>  498
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  498

Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn His Ala 
1               5                   10              


<210>  499
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  499

Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  500
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  500

Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Glx Tyr Ala 
1               5                   10              


<210>  501
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  501

Gly Gly Ile Ile Pro Ile Phe Gly Thr Gly Asn Tyr Ala 
1               5                   10              


<210>  502
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  502

Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro His Tyr Ala 
1               5                   10              


<210>  503
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  503

Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala 
1               5                   10              


<210>  504
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  504

Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala 
1               5                   10              


<210>  505
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  505

Gly Gly Ile Ile Pro Ile Ser Gly Lys Thr Asp Tyr Ala 
1               5                   10              


<210>  506
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  506

Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  507
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  507

Gly Gly Ile Ile Pro Leu Phe Gly Thr Thr Asp Tyr Ala 
1               5                   10              


<210>  508
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  508

Gly Gly Ile Ile Pro Arg Leu Gly Ala Thr Asp Tyr Ala 
1               5                   10              


<210>  509
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  509

Gly Gly Ile Leu Pro Ile Tyr Gly Thr Thr Lys Tyr Ala 
1               5                   10              


<210>  510
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  510

Gly Gly Met Asn Glx Asn Arg Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  511
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  511

Gly Gly Val Ile Pro Ala Phe Gly Ala Thr Asp Tyr Ser 
1               5                   10              


<210>  512
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  512

Gly Ile Ile Asn Pro Ser Gly Gly Arg Thr Thr Tyr Ala 
1               5                   10              


<210>  513
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  513

Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
1               5                   10              


<210>  514
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  514

Gly Ile Ile Asn Pro Ser Ser Gly Arg Thr Asp Tyr Ala 
1               5                   10              


<210>  515
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  515

Gly Ile Ile Ser Pro Gly Gly Gly Arg Thr Ile Tyr Ala 
1               5                   10              


<210>  516
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  516

Gly Ile Ile Ser Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
1               5                   10              


<210>  517
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  517

Gly Ile Ile Glx Pro Gly Gly Gly Arg Thr Ile Tyr Ala 
1               5                   10              


<210>  518
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  518

Gly Leu Ile Ser Arg Asn Ala Gly Asn Thr Leu Tyr Ala 
1               5                   10              


<210>  519
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  519

Gly Leu Val Cys Pro Ser Asp Gly Ser Thr Ser Tyr Ala 
1               5                   10              


<210>  520
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  520

Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala 
1               5                   10              


<210>  521
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  521

Gly Met Ile Ile Pro Phe Leu Gly Ile Thr Asn Tyr Ala 
1               5                   10              


<210>  522
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  522

Gly Met Ile Asn Pro Ile Gly Gly Ser Ile Asn Tyr Ala 
1               5                   10              


<210>  523
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  523

Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Thr Tyr Ala 
1               5                   10              


<210>  524
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  524

Gly Arg Ala Tyr Tyr Lys Ser Arg Trp Tyr Tyr Asp Tyr Ala 
1               5                   10                  


<210>  525
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  525

Gly Arg Ile Ile Pro Ala Leu Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  526
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  526

Gly Arg Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  527
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  527

Gly Arg Ile Ile Pro Ile Phe Gly Thr Ala Glx Tyr Ala 
1               5                   10              


<210>  528
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  528

Gly Arg Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala 
1               5                   10              


<210>  529
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  529

Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala 
1               5                   10              


<210>  530
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  530

Gly Arg Ile Ile Pro Ile Leu Gly Ser Ala Asn Tyr Ala 
1               5                   10              


<210>  531
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  531

Gly Arg Ile Ile Pro Ile Leu Gly Thr Pro Asn Tyr Ala 
1               5                   10              


<210>  532
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  532

Gly Arg Ile Ile Pro Leu Phe Gly Thr Thr Asn Tyr Ala 
1               5                   10              


<210>  533
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  533

Gly Arg Ile Ile Pro Thr Val Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  534
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  534

Gly Arg Ile Ile Pro Val Leu Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  535
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  535

Gly Arg Ile Lys Ser Lys Ala Asn Gly Gly Thr Thr Asp Tyr Ala 
1               5                   10                  15  


<210>  536
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  536

Gly Arg Ile Lys Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala 
1               5                   10                  15  


<210>  537
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  537

Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
1               5                   10              


<210>  538
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  538

Gly Arg Ile Ser Ala Tyr Asn Gly Tyr Lys Ser Tyr Ala 
1               5                   10              


<210>  539
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  539

Gly Arg Ile Thr Pro Val Val Gly Val Thr Asn Tyr Ala 
1               5                   10              


<210>  540
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  540

Gly Arg Ile Val Pro Ala Ile Gly Phe Thr Gln Tyr Ala 
1               5                   10              


<210>  541
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  541

Gly Arg Ile Val Pro Ile Val Asp Val Val Lys Tyr Ala 
1               5                   10              


<210>  542
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  542

Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
1               5                   10                  


<210>  543
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  543

Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Ser Asp Tyr Ala 
1               5                   10                  


<210>  544
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  544

Gly Arg Thr Tyr Tyr Arg Ser Lys Tyr Tyr Asn Gly Tyr Ala 
1               5                   10                  


<210>  545
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  545

Gly Arg Val Ile Pro Ile Leu Gly Val Thr Asn Tyr Ala 
1               5                   10              


<210>  546
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  546

Gly Ser Ile Tyr Phe Thr Gly Gly Thr Tyr Tyr Asn 
1               5                   10          


<210>  547
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  547

Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn 
1               5                   10          


<210>  548
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  548

Gly Ser Ile Tyr Tyr Thr Gly Asn Thr Tyr Tyr Asn 
1               5                   10          


<210>  549
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  549

Gly Thr Val Thr Pro Ile Leu Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  550
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  550

Gly Val Ile Asp Pro Ser Thr Gly Gly Thr Asn Tyr Ala 
1               5                   10              


<210>  551
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  551

Gly Val Ile Phe Pro Val Tyr Pro Thr Pro Asp Tyr Ala 
1               5                   10              


<210>  552
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  552

Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Ser Tyr Asn 
1               5                   10              


<210>  553
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  553

Gly Val Ile Ser Lys Asp Gly Asp Asn Lys Tyr Tyr Ala 
1               5                   10              


<210>  554
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  554

Gly Trp Ile Gly Pro His Asn Gly Asn Thr Asn Tyr Ala 
1               5                   10              


<210>  555
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  555

Gly Trp Ile Asn Ala Asp Thr Gly Asp Thr Ala Tyr Ser 
1               5                   10              


<210>  556
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  556

Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ala 
1               5                   10              


<210>  557
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  557

Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser 
1               5                   10              


<210>  558
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  558

Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Thr Tyr Ala 
1               5                   10              


<210>  559
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  559

Gly Trp Ile Asn Ala Lys Ser Gly Gly Thr Phe Tyr Ala 
1               5                   10              


<210>  560
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  560

Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn Tyr Ala 
1               5                   10              


<210>  561
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  561

Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Lys Phe Ala 
1               5                   10              


<210>  562
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  562

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Ile Tyr Ala 
1               5                   10              


<210>  563
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  563

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala 
1               5                   10              


<210>  564
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  564

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
1               5                   10              


<210>  565
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  565

Gly Trp Ile Asn Ser Gly Asn Gly Asn Thr Lys Tyr Ser 
1               5                   10              


<210>  566
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  566

Gly Trp Ile Asn Thr Tyr Asn Gly Asn Thr Ile Tyr Ala 
1               5                   10              


<210>  567
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  567

Gly Trp Ile Asn Thr Tyr Asn Gly Asn Thr Asn Tyr Pro 
1               5                   10              


<210>  568
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  568

Gly Trp Ile Ser Ala Tyr Asn Gly Asp Thr Lys Tyr Ala 
1               5                   10              


<210>  569
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  569

Gly Trp Ile Ser Ala Tyr Asn Gly His Thr Asn Tyr Ala 
1               5                   10              


<210>  570
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  570

Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala 
1               5                   10              


<210>  571
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  571

Gly Trp Ile Ser Pro Asn Arg Gly Gly Thr Asn Tyr Ala 
1               5                   10              


<210>  572
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  572

Gly Trp Ile Ser Pro Tyr Asn Gly Asn Thr Lys Tyr Ala 
1               5                   10              


<210>  573
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  573

Gly Trp Ile Ser Pro Tyr Asn Gly Asn Thr Asn Tyr Ala 
1               5                   10              


<210>  574
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  574

Gly Trp Ile Ser Pro Tyr Asn Gly Tyr Thr Lys Tyr Ala 
1               5                   10              


<210>  575
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  575

Gly Trp Ile Ser Ser Phe Asn Gly Asn Thr Lys Tyr Ala 
1               5                   10              


<210>  576
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  576

Gly Trp Ile Ser Thr Phe Asn Asp Asn Thr Asn Tyr Ala 
1               5                   10              


<210>  577
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  577

Gly Trp Ile Ser Thr Tyr Asn Gly Ala Thr Asn Tyr Ala 
1               5                   10              


<210>  578
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  578

Gly Trp Ile Tyr Pro Asn Ser Gly Gly Thr Lys Tyr Ala 
1               5                   10              


<210>  579
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  579

Gly Trp Met Asn Pro Asp Ser Gly Lys Thr Gly Tyr Ala 
1               5                   10              


<210>  580
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  580

Gly Trp Met Asn Pro Ile Ser Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  581
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  581

Gly Trp Met Asn Pro Asn Asn Gly Asn Thr Thr Tyr Ala 
1               5                   10              


<210>  582
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  582

Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Ala Tyr Ala 
1               5                   10              


<210>  583
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  583

Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  584
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  584

Gly Trp Met Ser Pro Asn Ser Gly Asn Ala Gly Phe Ala 
1               5                   10              


<210>  585
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  585

Gly Trp Met Ser Pro Ser Ser Gly Asn Ala Gly Tyr Ala 
1               5                   10              


<210>  586
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  586

Gly Trp Val Asn Pro Thr Thr Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  587
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  587

Gly Trp Val Ser Pro Asn Thr Gly Asn Thr Val Tyr Ala 
1               5                   10              


<210>  588
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  588

Gly Trp Val Ser Pro Ser Ser Gly Asn Thr Ala Tyr Ala 
1               5                   10              


<210>  589
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  589

Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn 
1               5                   10          


<210>  590
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  590

Pro Arg Ile Pro Ser Asp Ser Thr Thr Phe Tyr Ala 
1               5                   10          


<210>  591
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  591

Ser Ala Ile Asp Gly Ala Gly Arg Thr Tyr Tyr Thr 
1               5                   10          


<210>  592
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  592

Ser Ala Ile Asp Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  593
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  593

Ser Ala Ile Gly Ala Gly Gly Gly Thr Tyr Tyr Ala 
1               5                   10          


<210>  594
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  594

Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala 
1               5                   10          


<210>  595
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  595

Ser Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala 
1               5                   10          


<210>  596
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  596

Ser Ala Ile Ser Ala Ser Gly Asp Ser Thr Phe Tyr Ala 
1               5                   10              


<210>  597
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  597

Ser Ala Ile Ser Gly Asp Gly Ala Leu Thr Tyr Tyr Ala 
1               5                   10              


<210>  598
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  598

Ser Ala Ile Ser Gly Ser Gly Ala Thr Thr Thr Tyr Ala 
1               5                   10              


<210>  599
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  599

Ser Ala Ile Ser Gly Ser Gly Phe Thr Tyr Tyr Ala 
1               5                   10          


<210>  600
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  600

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  601
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  601

Ser Ala Ile Ser Asn Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  602
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  602

Ser Ala Ile Ser Val Ser Gly Gly Thr Thr Phe Tyr Ala 
1               5                   10              


<210>  603
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  603

Ser Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  604
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  604

Ser Ala Val Ser Gly Asn Gly Gly Gly Thr Phe Tyr Ala 
1               5                   10              


<210>  605
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  605

Ser Gly Ile Gly Val Gly Gly Gly Thr Tyr Tyr Ala 
1               5                   10          


<210>  606
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  606

Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala 
1               5                   10              


<210>  607
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  607

Ser Gly Ile Asn Trp Asn Ser Ala Lys Ile Gly Tyr Val 
1               5                   10              


<210>  608
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  608

Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  609
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  609

Ser Gly Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala 
1               5                   10              


<210>  610
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  610

Ser Gly Ile Ser Gly Ser Gly Arg Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  611
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  611

Ser Gly Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  612
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  612

Ser Gly Ile Ser Gly Ser Gly Thr Thr Thr Tyr Tyr Arg 
1               5                   10              


<210>  613
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  613

Ser Gly Ile Ser Arg Asp Gly Gly Arg Thr Ser Tyr Ser 
1               5                   10              


<210>  614
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  614

Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala 
1               5                   10              


<210>  615
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  615

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala 
1               5                   10              


<210>  616
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  616

Ser Gly Ile Thr Gly Ser Gly Gly Arg Thr Phe Tyr Ala 
1               5                   10              


<210>  617
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  617

Ser Gly Val Gly Gly Ser Gly Gly Ser Thr Glx Tyr Ala 
1               5                   10              


<210>  618
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  618

Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Val 
1               5                   10              


<210>  619
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  619

Ser His Ile Ser Ser Gly Gly Ala Thr Ile Asp Tyr Ala 
1               5                   10              


<210>  620
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  620

Ser Leu Ile Ser Gly Ser Gly Asp Asn Thr Asn Tyr Ala 
1               5                   10              


<210>  621
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  621

Ser Leu Val Ser Phe Asp Gly Ser Lys Glu His Tyr Ala 
1               5                   10              


<210>  622
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  622

Ser Arg Ile Asp Thr Asp Gly Ser Thr Thr Val Tyr Ala 
1               5                   10              


<210>  623
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  623

Ser Arg Ile Asn Gly Asp Gly Ser Asn Thr Asn Tyr Ala 
1               5                   10              


<210>  624
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  624

Ser Arg Ile Asn Gly Asp Gly Ser Ser Thr Arg Tyr Ala 
1               5                   10              


<210>  625
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  625

Ser Arg Ile Asn Ser Asp Gly Ser Thr Ile Ser Tyr Ala 
1               5                   10              


<210>  626
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  626

Ser Arg Ile Asn Tyr Asp Gly Ser Ala Thr Thr Tyr Ala 
1               5                   10              


<210>  627
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  627

Ser Arg Ile Ser Asn Ser Gly Ser Leu Val Tyr Tyr Ala 
1               5                   10              


<210>  628
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  628

Ser Arg Ile Ser Pro Asp Gly Arg Thr Thr Thr Tyr Ala 
1               5                   10              


<210>  629
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  629

Ser Ser Ile Asp Gly Asn Gly Asp His Val Phe Tyr Ala 
1               5                   10              


<210>  630
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  630

Ser Ser Ile Asn Asn Ser Ser Arg Thr Val Phe Tyr Ala 
1               5                   10              


<210>  631
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  631

Ser Ser Ile Ser Ala Ala Gly Ala Tyr Lys Tyr Tyr Ala 
1               5                   10              


<210>  632
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  632

Ser Ser Ile Ser Gly Gly Gly Arg His Thr Tyr Tyr Ala 
1               5                   10              


<210>  633
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  633

Ser Ser Ile Ser Gly Leu Gly Gly Ser Thr Tyr Glx Ala 
1               5                   10              


<210>  634
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  634

Ser Ser Ile Ser Ser Gly Asn Ser Tyr Ile Tyr Tyr Ala 
1               5                   10              


<210>  635
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  635

Ser Ser Ile Ser Ser Ser Ser His Tyr Lys Tyr Tyr Ala 
1               5                   10              


<210>  636
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  636

Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala 
1               5                   10              


<210>  637
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  637

Ser Ser Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  638
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  638

Ser Ser Ile Ser Trp Asn Ser Gly Arg Val Asp Tyr Ala 
1               5                   10              


<210>  639
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  639

Ser Ser Ile Thr Arg Thr Pro Ser Gly Gly Thr Thr Glu Tyr Ala 
1               5                   10                  15  


<210>  640
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  640

Ser Ser Ile Thr Thr Thr Ser Thr Leu Tyr Ala 
1               5                   10      


<210>  641
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  641

Ser Ser Leu Ser Trp Asn Ser Gly Thr Ile Val Tyr Ala 
1               5                   10              


<210>  642
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  642

Ser Ser Thr Ser Gly Ser Gly Gly Asn Ser Lys Tyr Ser 
1               5                   10              


<210>  643
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  643

Ser Thr Ile Ala Gly Ser Gly Gly Arg Thr Tyr Tyr Ser 
1               5                   10              


<210>  644
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  644

Ser Thr Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Pro 
1               5                   10          


<210>  645
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  645

Ser Thr Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala 
1               5                   10          


<210>  646
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  646

Ser Thr Ile Ser Gly Gly Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  647
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  647

Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ser 
1               5                   10              


<210>  648
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  648

Ser Thr Ile Ser Gly Ser Gly Val Ser Thr Phe Tyr Ala 
1               5                   10              


<210>  649
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  649

Ser Thr Ile Ser Pro Ser Gly Leu Tyr Ile Tyr Gln Ala 
1               5                   10              


<210>  650
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  650

Ser Thr Ile Ser Ser Ser Gly Gly Arg Thr Phe Tyr Ala 
1               5                   10              


<210>  651
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  651

Ser Val Ile Ser Ser Gly Gly Ser Pro Tyr Tyr Ala 
1               5                   10          


<210>  652
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  652

Ser Val Ile Ser Thr Ser Gly Asp Thr Val Leu Tyr Thr 
1               5                   10              


<210>  653
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  653

Ser Val Ile Tyr Gly Gly Gly Asn Thr Asn Tyr Ala 
1               5                   10          


<210>  654
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  654

Ser Tyr Ile Glu Asn Asp Gly Ser Ile Thr Thr Tyr Ala 
1               5                   10              


<210>  655
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  655

Ser Tyr Ile Gly Thr Ser Asp Gly Thr Thr Tyr Tyr Ala 
1               5                   10              


<210>  656
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  656

Ser Tyr Ile Ser Ala Gly Asp Gly Phe Thr Tyr Tyr Ala 
1               5                   10              


<210>  657
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  657

Ser Tyr Ile Ser Gly Ala Gly Gly Ser Thr Glu Tyr Ala 
1               5                   10              


<210>  658
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  658

Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala 
1               5                   10              


<210>  659
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  659

Ser Tyr Ile Ser Ser Gly Ser Tyr Thr Ile Tyr Tyr Ser 
1               5                   10              


<210>  660
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  660

Ser Tyr Ile Ser Ser Ser Gly Ser Ile Thr His Tyr Ala 
1               5                   10              


<210>  661
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  661

Ser Tyr Ile Ser Ser Ser Ser Ser Ala Ile Tyr Tyr Ala 
1               5                   10              


<210>  662
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  662

Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala 
1               5                   10              


<210>  663
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  663

Ser Tyr Ile Ser Thr Ser Asp Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  664
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  664

Ser Tyr Ser Ser Gly Asn Ser Gly Tyr Thr Asn Tyr Ala 
1               5                   10              


<210>  665
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  665

Thr Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  666
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  666

Thr Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ser 
1               5                   10              


<210>  667
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  667

Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  668

<400>  668
000

<210>  669

<400>  669
000

<210>  670

<400>  670
000

<210>  671

<400>  671
000

<210>  672

<400>  672
000

<210>  673

<400>  673
000

<210>  674

<400>  674
000

<210>  675

<400>  675
000

<210>  676

<400>  676
000

<210>  677

<400>  677
000

<210>  678
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  678

Cys Ala Ala Ala Ser Ser Leu Thr Ser Thr Pro Tyr Asp Leu Trp 
1               5                   10                  15  


<210>  679
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  679

Cys Ala Ala Asp Arg Ser Pro Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 
1               5                   10                  15      


Pro Asp Ala Phe Asp Ile Trp 
            20              


<210>  680
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  680

Cys Ala Ala Gly Phe Pro Thr Val Phe Val Val Asp Gly Glu Tyr Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  681
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  681

Cys Ala Ala Gly Pro Ile Ala Arg Trp Tyr Arg Gly Asp Met Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  682
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  682

Cys Ala Ala Gly Pro Asn Tyr Ser Trp Phe Met Pro Ser Ser Ser Arg 
1               5                   10                  15      


Leu Ile Trp 
            


<210>  683
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  683

Cys Ala Ala Gly Pro Thr Leu Pro Phe Arg Tyr Trp 
1               5                   10          


<210>  684
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  684

Cys Ala Ala Gly Val Thr Gly Ser Trp Arg Tyr Trp 
1               5                   10          


<210>  685
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  685

Cys Ala Ala Pro Asp Val Val Val Thr Ala Asp Gly Tyr Tyr Trp 
1               5                   10                  15  


<210>  686
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  686

Cys Ala Ala Pro Asp Tyr Trp 
1               5           


<210>  687
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  687

Cys Ala Ala Pro Gln Ser Pro Asn Met Tyr Ile Arg Thr Asp Gln Leu 
1               5                   10                  15      


Trp Trp Tyr Lys Tyr Trp 
            20          


<210>  688
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  688

Cys Ala Ala Gln Lys Pro Tyr Tyr Asn Gly His Phe Tyr Ala Asp Asp 
1               5                   10                  15      


Lys His Tyr Asp His Trp 
            20          


<210>  689
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  689

Cys Ala Ala Val Phe Leu Ser Arg Asn Tyr Glu Ile Gln Glu Tyr Tyr 
1               5                   10                  15      


Arg Tyr Gln 
            


<210>  690
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  690

Cys Ala Asp Gly Ser Gly Thr Ser His Arg 
1               5                   10  


<210>  691
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  691

Cys Ala Glu Ser Leu Thr Ser Thr Ala Asp Trp 
1               5                   10      


<210>  692
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  692

Cys Ala Gly Gly Glu Val Tyr Glu Leu 
1               5                   


<210>  693
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  693

Cys Ala His Ser Asp Phe Phe Ser Gly Leu Ser Phe Gly Asp Trp 
1               5                   10                  15  


<210>  694
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  694

Cys Ala Ile Arg Ala Phe Asp Ile Trp 
1               5                   


<210>  695
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  695

Cys Ala Lys Ala Gly Asp Trp Gly Leu Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  696
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  696

Cys Ala Lys Ala Gly Gln Gln Leu Asp Trp 
1               5                   10  


<210>  697
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  697

Cys Ala Lys Ala Ser Thr Pro Met Val Gln Gly Ala Pro Asp Tyr Trp 
1               5                   10                  15      


<210>  698
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  698

Cys Ala Lys Asp Gly Val Val Arg 
1               5               


<210>  699
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  699

Cys Ala Lys Asp Gly Tyr Trp 
1               5           


<210>  700
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  700

Cys Ala Lys Asp His Leu Ala Val Ala Asp Ala His Gly Arg 
1               5                   10                  


<210>  701
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  701

Cys Ala Lys Asp Ile Gly Ser Ser Trp Tyr Tyr Tyr Met Asp Val Trp 
1               5                   10                  15      


<210>  702
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  702

Cys Ala Lys Asp Ile Thr Pro Tyr Gly Asp Tyr Ser Ile Leu Ser His 
1               5                   10                  15      


Trp 
    


<210>  703
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  703

Cys Ala Lys Asp Lys Val Pro Tyr Ser Tyr Gly Pro Asn Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  704
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  704

Cys Ala Lys Asp Leu Val Pro Trp Gly Ser Ser Ala Phe Asn Ile Trp 
1               5                   10                  15      


<210>  705
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  705

Cys Ala Lys Asp Leu Val Pro Tyr Cys Ser Gly Gly Ser Cys Pro Pro 
1               5                   10                  15      


Ser Gly Trp 
            


<210>  706
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  706

Cys Ala Lys Asp Asn Gly Trp Tyr Phe Asp Leu Trp 
1               5                   10          


<210>  707
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  707

Cys Ala Lys Asp Arg Gly Asn Tyr Gly Asp Tyr Leu Asp Tyr Trp 
1               5                   10                  15  


<210>  708
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  708

Cys Ala Lys Asp Arg Gly Tyr Ser Ser Gly Trp Tyr Leu Asp Tyr Trp 
1               5                   10                  15      


<210>  709
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  709

Cys Ala Lys Asp Ser Ile Gly Arg Arg Gly Arg Gly Ala Pro Gln Pro 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
            20                  25  


<210>  710
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  710

Cys Ala Lys Asp Val Asn Tyr Trp 
1               5               


<210>  711
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  711

Cys Ala Lys Gly Ala Gly Tyr Gly Ser Gly Ser Trp Gln Ala Ala Trp 
1               5                   10                  15      


<210>  712
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  712

Cys Ala Lys Gly Asp Tyr Gly Ala Leu Asp Tyr Trp 
1               5                   10          


<210>  713
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  713

Cys Ala Lys Gly Gly Gln Trp Leu Tyr Gly Met Asp Val Trp 
1               5                   10                  


<210>  714
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  714

Cys Ala Lys Gly Gly Arg Asp Gly Tyr Lys Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  715
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  715

Cys Ala Lys Gly Gly Trp Arg Ser Ser Phe Asp Pro Trp 
1               5                   10              


<210>  716
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  716

Cys Ala Lys Gly Ile Arg Trp Phe Asp Pro Trp 
1               5                   10      


<210>  717
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  717

Cys Ala Lys Gly Ile Val Gly Asp Tyr Gly Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  718
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  718

Cys Ala Lys Gly Leu Trp Gly Pro Leu Leu Asn Trp 
1               5                   10          


<210>  719
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  719

Cys Ala Lys Gly Asn Trp Ala Phe Asp Ile Trp 
1               5                   10      


<210>  720
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  720

Cys Ala Lys Gly Ser Leu Leu Leu Gly Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15      


<210>  721
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  721

Cys Ala Lys Gly Ser Val Phe Gly Leu Lys Ala Gly Gly Tyr Ala Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  722
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  722

Cys Ala Lys Gly Ser Tyr Tyr Tyr Asp Asn Ser Gly Tyr Tyr Trp Asp 
1               5                   10                  15      


Ala Phe Asp Ile Trp 
            20      


<210>  723
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  723

Cys Ala Lys Gly Ser Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Trp Asp 
1               5                   10                  15      


Ala Phe Asp Ile Trp 
            20      


<210>  724
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  724

Cys Ala Lys Leu Gly Gly Ser Ser Trp Leu Arg Glu Tyr Asp Tyr Trp 
1               5                   10                  15      


<210>  725
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  725

Cys Ala Lys Pro Gly Ile Ala Ala Ala Gly Thr Asn Asn Trp Phe Asp 
1               5                   10                  15      


Pro Trp 
        


<210>  726
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  726

Cys Ala Lys Thr Gly Arg Gly Tyr Ala Phe Asp Ile Trp 
1               5                   10              


<210>  727
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  727

Cys Ala Lys Thr Lys Leu Pro Ile Trp 
1               5                   


<210>  728
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  728

Cys Ala Lys Thr Leu Val Thr Ser His Ala Leu His Ile Trp 
1               5                   10                  


<210>  729
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  729

Cys Ala Lys Trp His Ile Gly Ala Thr Gly Asn Trp Phe Asp Pro Trp 
1               5                   10                  15      


<210>  730
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  730

Cys Ala Leu Leu Val Gly Ala Ala Arg Gly Ile Ser Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val Trp 
            20          


<210>  731
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  731

Cys Ala Leu Ser Ser Ser Trp Tyr Gly Gly Phe Asp Tyr Trp 
1               5                   10                  


<210>  732
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  732

Cys Ala Asn Gly Ser Tyr Ala Gln His Leu Trp 
1               5                   10      


<210>  733
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  733

Cys Ala Pro Asn Glu Ser Gly Asn Val Asp Tyr Trp 
1               5                   10          


<210>  734
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  734

Cys Ala Pro Arg Val Leu Val Thr Ala Pro Ser Gly Gly Met Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  735
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  735

Cys Ala Gln Gly Thr Tyr Trp 
1               5           


<210>  736
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  736

Cys Ala Arg Ala Ala Ala Gly Ser Tyr Gly Gly Gly Tyr Trp 
1               5                   10                  


<210>  737
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  737

Cys Ala Arg Ala Ala Leu Gly Tyr Cys Thr Gly Gly Val Cys Pro Pro 
1               5                   10                  15      


Val Asp Tyr Trp 
            20  


<210>  738
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  738

Cys Ala Arg Ala Asp Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Gly 
1               5                   10                  15      


Phe Asp Tyr Trp 
            20  


<210>  739
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  739

Cys Ala Arg Ala Gly Asp Ser Pro Asp Tyr Trp 
1               5                   10      


<210>  740
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  740

Cys Ala Arg Ala Gly Ser Gly Tyr Tyr Asn Phe Asp Tyr Trp 
1               5                   10                  


<210>  741
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  741

Cys Ala Arg Ala Gly Val Ala Thr Ile Ala Phe Asp Tyr Trp 
1               5                   10                  


<210>  742
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  742

Cys Ala Arg Ala Ile Pro Gly Asp Tyr Asp Tyr Trp 
1               5                   10          


<210>  743
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  743

Cys Ala Arg Ala Ile Val Gly Ala Thr Gly Leu Asn Arg Phe Lys Ala 
1               5                   10                  15      


Phe Asp Ile Trp 
            20  


<210>  744
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  744

Cys Ala Arg Ala Lys Gly Ser Gly Trp Tyr Val Gly Ser Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  745
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  745

Cys Ala Arg Ala Met Trp Ser Tyr Gly Gln Gln Asn Ala Phe Asp Ile 
1               5                   10                  15      


Trp 
    


<210>  746
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  746

Cys Ala Arg Ala Pro Leu Asp Gly Ser Gly Ser Tyr Tyr Val Asp Trp 
1               5                   10                  15      


<210>  747
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  747

Cys Ala Arg Ala Pro Ser Tyr Ser Ser Gly Trp Tyr Val Arg Trp 
1               5                   10                  15  


<210>  748
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  748

Cys Ala Arg Ala Pro Tyr Tyr Tyr Gly Ser Gly Ser Leu Phe Arg Leu 
1               5                   10                  15      


Asp Tyr Trp 
            


<210>  749
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  749

Cys Ala Arg Ala Arg Gly Gly Asp Ser Pro Leu Ser Leu 
1               5                   10              


<210>  750
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  750

Cys Ala Arg Ala Arg Leu Leu Gly Gly Tyr Tyr Thr Pro Asp Arg Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  751
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  751

Cys Ala Arg Ala Arg Ser Ser Gly Trp Thr Asp Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  752
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  752

Cys Ala Arg Ala Ser Ala Trp Thr Pro Tyr Gly Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  753
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  753

Cys Ala Arg Ala Ser Leu Tyr Tyr Asp Tyr Val Trp Gly Ser Tyr Arg 
1               5                   10                  15      


His Tyr Tyr Phe Asp Tyr Trp 
            20              


<210>  754
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  754

Cys Ala Arg Ala Ser Arg Ile Asp Gly Gly Trp Pro Ile Ile Asp His 
1               5                   10                  15      


Leu 
    


<210>  755
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  755

Cys Ala Arg Ala Ser Ser Trp Tyr Leu His Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  756
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  756

Cys Ala Arg Ala Ser Thr Ser Gly Asp Tyr Ser Leu Trp 
1               5                   10              


<210>  757
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  757

Cys Ala Arg Ala Thr Gly Phe Gly Thr Val Val Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  758
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  758

Cys Ala Arg Ala Thr Gln Glu Leu Leu Leu Pro Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  759
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  759

Cys Ala Arg Ala Thr Ser Leu Gly Arg Arg Tyr Cys Ser Ser Thr Ser 
1               5                   10                  15      


Cys Tyr Pro Arg Asp Ala Phe Asp Ile Trp 
            20                  25      


<210>  760
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  760

Cys Ala Arg Ala Thr Tyr Gly Gly Asp Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  761
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  761

Cys Ala Arg Ala Trp Lys Gly Leu Trp Phe Gly Glu Gly Thr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  762
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  762

Cys Ala Arg Asp Ala Asp Ser Ser Gly Tyr Tyr Arg Tyr Asp Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  763
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  763

Cys Ala Arg Asp Ala Tyr Asn Trp Phe Asp Pro Arg 
1               5                   10          


<210>  764
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  764

Cys Ala Arg Asp Ala Tyr Asn Trp Phe Asp Pro Trp 
1               5                   10          


<210>  765
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  765

Cys Ala Arg Asp Cys Ser Gly Gly Ser Cys Tyr Ser His Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  766
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  766

Cys Ala Arg Asp Glu Gly Ala Gly Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  767
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  767

Cys Ala Arg Asp Gly Gly Asp Tyr Gly Met Asp Val Trp 
1               5                   10              


<210>  768
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  768

Cys Ala Arg Asp Gly Gly Tyr Trp 
1               5               


<210>  769
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  769

Cys Ala Arg Asp Gly Ile Trp Asp Ile Phe Asp Tyr Trp 
1               5                   10              


<210>  770
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  770

Cys Ala Arg Asp Gly Ser Ser Gly Trp Tyr Ser Pro Asn Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  771
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  771

Cys Ala Arg Asp Gly Ser Trp 
1               5           


<210>  772
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  772

Cys Ala Arg Asp Gly Thr Pro Phe Tyr Ser Gly Ser Tyr Tyr Gly Ser 
1               5                   10                  15      


Trp 
    


<210>  773
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  773

Cys Ala Arg Asp Gly Val Glu 
1               5           


<210>  774
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  774

Cys Ala Arg Asp His Gly Ser Ser Trp Tyr Gln Asn Thr Asp Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  775
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  775

Cys Ala Arg Asp Ile Thr Gly Ala Asp Gly Met Asp Val Trp 
1               5                   10                  


<210>  776
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  776

Cys Ala Arg Asp Leu Asp Ser Gly Phe Asp Leu Trp 
1               5                   10          


<210>  777
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  777

Cys Ala Arg Asp Leu Met Val Gly Arg Asn Lys Leu Asp Tyr Trp 
1               5                   10                  15  


<210>  778
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  778

Cys Ala Arg Asp Leu Arg Phe Tyr Ser Ser Ser Trp Arg Arg Val Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  779
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  779

Cys Ala Arg Asp Leu Ser Pro Met Val Arg Gly Val Ile Ser Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  780
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  780

Cys Ala Arg Asp Leu Thr Pro Phe Thr Gln Gln Gln Leu Val Leu Gly 
1               5                   10                  15      


Leu Leu 
        


<210>  781
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  781

Cys Ala Arg Asp Leu Thr Tyr Tyr Tyr Asp Ser Ser Gly His Ser Pro 
1               5                   10                  15      


Leu Gly Ala Phe Asp Ile Trp 
            20              


<210>  782
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  782

Cys Ala Arg Asp Leu Val Ala Ala Arg Pro Ser Asn Trp Asp Tyr Trp 
1               5                   10                  15      


<210>  783
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  783

Cys Ala Arg Asp Asn Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Ala Thr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val Arg 
            20              


<210>  784
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  784

Cys Ala Arg Asp Pro Ile Met Phe Gly Asp Gln Pro Gly Trp Phe Asp 
1               5                   10                  15      


Pro Trp 
        


<210>  785
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  785

Cys Ala Arg Asp Gln Asn Asp Ser Trp Tyr Arg Ser Asp Tyr Trp 
1               5                   10                  15  


<210>  786
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  786

Cys Ala Arg Asp Arg Asp Ile Val Val Val Pro Ala Gln Arg Gly Glu 
1               5                   10                  15      


Gly Gly Phe Asp Pro Trp 
            20          


<210>  787
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  787

Cys Ala Arg Asp Arg Asp Tyr Trp 
1               5               


<210>  788
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  788

Cys Ala Arg Asp Arg Phe Asp Asn Trp Phe Asp Pro Trp 
1               5                   10              


<210>  789
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  789

Cys Ala Arg Asp Arg Leu Ala Phe Asp Tyr Trp 
1               5                   10      


<210>  790
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  790

Cys Ala Arg Asp Arg Pro Gly Phe Asp Pro Trp 
1               5                   10      


<210>  791
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  791

Cys Ala Arg Asp Arg Pro Ser Ser Ser Trp Tyr Ala Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  792
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  792

Cys Ala Arg Asp Arg Pro Thr Ser Ser Trp Tyr Ala Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  793
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  793

Cys Ala Arg Asp Arg Pro Tyr Ser Ser Gly Trp Tyr Tyr Pro Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  794
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  794

Cys Ala Arg Asp Arg Gln Leu Gly Trp Ala His Trp Tyr Phe Asp Leu 
1               5                   10                  15      


Trp 
    


<210>  795
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  795

Cys Ala Arg Asp Arg Arg Gly Tyr Gly Met Asp Val Trp 
1               5                   10              


<210>  796
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  796

Cys Ala Arg Asp Arg Val Thr Leu Arg Gly Gly Tyr Ser Tyr Gly Thr 
1               5                   10                  15      


Asp Ala Phe Asp Ile Trp 
            20          


<210>  797
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  797

Cys Ala Arg Asp Ser Asp Phe Trp Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15      


<210>  798
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  798

Cys Ala Arg Asp Ser Ser Ser Gly Trp Tyr Ala Ser Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  799
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  799

Cys Ala Arg Asp Ser Ser Ser Trp Tyr Ser Tyr Tyr Tyr Tyr Tyr Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  800
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  800

Cys Ala Arg Asp Ser Tyr Pro Tyr Gly Met Asp Val Trp 
1               5                   10              


<210>  801
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  801

Cys Ala Arg Asp Thr Cys Ser Ser Thr Ser Cys Ser Pro Asp Tyr Trp 
1               5                   10                  15      


<210>  802
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  802

Cys Ala Arg Asp Val Cys Ser Gly Gly Ser Cys Ser Pro Asp Val Trp 
1               5                   10                  15      


<210>  803
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  803

Cys Ala Arg Asp Val Met Asp Val Trp 
1               5                   


<210>  804
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  804

Cys Ala Arg Asp Val Pro Lys Leu Val Thr Arg Gly Val Ala Tyr Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  805
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  805

Cys Ala Arg Glu Ala Gly Thr Thr Gly Gly Trp Phe Asp Pro Trp 
1               5                   10                  15  


<210>  806
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  806

Cys Ala Arg Glu Ala Asn Tyr Asp Ile Leu Thr Gly Tyr Ile Arg Pro 
1               5                   10                  15      


Asp Ala Phe Asp Ile Trp 
            20          


<210>  807
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  807

Cys Ala Arg Glu Glu Trp Glu Leu Phe Gly Met Asp Val Trp 
1               5                   10                  


<210>  808
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  808

Cys Ala Arg Glu Gly Arg Ser Arg Val Tyr Gly Gly Asn Ser Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  809
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  809

Cys Ala Arg Glu Gly Ser Tyr Tyr Asp Trp Tyr Phe Asp Leu Trp 
1               5                   10                  15  


<210>  810
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  810

Cys Ala Arg Glu Gly Trp Phe Gly Glu Ser Pro Phe Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  811
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  811

Cys Ala Arg Glu Gly Tyr Asp Phe Trp Ser Gly Pro Tyr Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  812
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  812

Cys Ala Arg Glu Leu Leu Pro Met Thr Thr Val Thr Ser Pro Phe Ile 
1               5                   10                  15      


Trp 
    


<210>  813
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  813

Cys Ala Arg Glu Ser Val Asn Asn Tyr Tyr Tyr Met Asp Val Trp 
1               5                   10                  15  


<210>  814
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  814

Cys Ala Arg Glu Thr Thr Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  815
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  815

Cys Ala Arg Glu Tyr Leu Gly Ser Phe Asp Ile Trp 
1               5                   10          


<210>  816
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  816

Cys Ala Arg Phe Asp Tyr Phe Gly Gly Met Asp Val Trp 
1               5                   10              


<210>  817
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  817

Cys Ala Arg Phe Tyr Tyr Asp Ile Leu Asn Gly Tyr Ser Tyr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  818
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  818

Cys Ala Arg Phe Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Tyr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  819
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  819

Cys Ala Arg Gly Ala Leu Gly Met Asp Val Trp 
1               5                   10      


<210>  820
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  820

Cys Ala Arg Gly Ala Arg Leu Asp Tyr Trp 
1               5                   10  


<210>  821
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  821

Cys Ala Arg Gly Ala Arg Leu Tyr Gly Cys Asp Tyr Trp 
1               5                   10              


<210>  822
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  822

Cys Ala Arg Gly Ala Arg Leu Tyr Gly Phe Asp Tyr Trp 
1               5                   10              


<210>  823
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  823

Cys Ala Arg Gly Asp Ser Gly Ser Tyr Arg Asp Tyr Trp 
1               5                   10              


<210>  824
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  824

Cys Ala Arg Gly Asp Tyr Asp Phe Trp Ser Gly Tyr His Glu Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val Trp 
            20              


<210>  825
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  825

Cys Ala Arg Gly Phe Cys Ser Gly Gly Ser Cys Leu Trp Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  826
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  826

Cys Ala Arg Gly Gly Ala Gly Arg Phe Gly Glu Gly Met Asp Val Trp 
1               5                   10                  15      


<210>  827
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  827

Cys Ala Arg Gly Gly Glu Tyr Ser Ser Gly Trp Thr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val Trp 
            20          


<210>  828
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  828

Cys Ala Arg Gly Gly Phe Val Phe Asp Tyr Trp 
1               5                   10      


<210>  829
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  829

Cys Ala Arg Gly Gly Gly Tyr Ser Ser Ser Trp 
1               5                   10      


<210>  830
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  830

Cys Ala Arg Gly Gly Leu Asp Gly Pro Ile Asp Tyr Arg 
1               5                   10              


<210>  831
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  831

Cys Ala Arg Gly Gly Leu Leu Phe Asp Tyr Trp 
1               5                   10      


<210>  832
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  832

Cys Ala Arg Gly Gly Leu Leu Arg Phe Gly Asp Gly Trp Gly Met Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  833
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  833

Cys Ala Arg Gly Gly Asn Tyr Gly Ser Gly Asp Tyr Trp 
1               5                   10              


<210>  834
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  834

Cys Ala Arg Gly Gly Pro Ile His Tyr Tyr Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  835
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  835

Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly His Tyr His Gly 
1               5                   10                  15      


Leu Asp Val Trp 
            20  


<210>  836
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  836

Cys Ala Arg Gly Gly Ser Gly Gly Asn Leu Ser Tyr Trp 
1               5                   10              


<210>  837
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  837

Cys Ala Arg Gly Gly Ser Arg Tyr Asp Phe Trp Ser Gly His Trp Tyr 
1               5                   10                  15      


Phe Asp Leu Trp 
            20  


<210>  838
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  838

Cys Ala Arg Gly Gly Ser Ser Asp Val Arg 
1               5                   10  


<210>  839
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  839

Cys Ala Arg Gly Gly Ser Thr Gly Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  840
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  840

Cys Ala Arg Gly Gly Trp Arg Pro Asp Tyr Tyr Gly Ser Gly Ser Tyr 
1               5                   10                  15      


Tyr Ser Phe Asp Tyr Trp 
            20          


<210>  841
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  841

Cys Ala Arg Gly Gly Trp Thr Asn Tyr Gly Gly Asn Leu Asp Tyr Trp 
1               5                   10                  15      


<210>  842
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  842

Cys Ala Arg Gly Gly Tyr Ser Tyr Gly Thr Val Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  843
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  843

Cys Ala Arg Gly Gly Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10              


<210>  844
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  844

Cys Ala Arg Gly Lys Glu Gly Arg Tyr Ser Asn Tyr Glu Ala Ala Trp 
1               5                   10                  15      


<210>  845
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  845

Cys Ala Arg Gly Lys Gly Tyr Ser Tyr Gly Tyr Gly Lys Asp Trp Phe 
1               5                   10                  15      


Asp Pro Trp 
            


<210>  846
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  846

Cys Ala Arg Gly Lys Ser Gly Ser Phe Asp Tyr Trp 
1               5                   10          


<210>  847
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  847

Cys Ala Arg Gly Leu Pro Pro Ala Ala Gly Gly Gly Gly Tyr Phe Gln 
1               5                   10                  15      


His Trp 
        


<210>  848
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  848

Cys Ala Arg Gly Leu Arg Tyr Phe Asp Trp Pro Gln Gly Ile Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val Trp 
            20              


<210>  849
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  849

Cys Ala Arg Gly Leu Val Ile Ala Thr Asn Trp Phe Asp Pro Trp 
1               5                   10                  15  


<210>  850
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  850

Cys Ala Arg Gly Asn Pro Thr Ser Gly His Ile Val Val Val Pro Ala 
1               5                   10                  15      


Ala Thr Phe Ser Asp Tyr Trp 
            20              


<210>  851
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  851

Cys Ala Arg Gly Pro Lys Thr Met Trp Glu Asp Arg Pro Asp Tyr Trp 
1               5                   10                  15      


<210>  852
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  852

Cys Ala Arg Gly Pro Leu Pro Thr Lys Ile Gly Gly His Tyr Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  853
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  853

Cys Ala Arg Gly Pro Arg Asp Ser Gly Tyr Tyr Pro Gly Gly Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  854
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  854

Cys Ala Arg Gly Pro Ser His Gln His Thr Phe Asp Ile Trp 
1               5                   10                  


<210>  855
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  855

Cys Ala Arg Gly Gln Gly Tyr Ser Ser Gly Trp Tyr Arg Gly Asp Ala 
1               5                   10                  15      


Phe Asp Ile Trp 
            20  


<210>  856
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  856

Cys Ala Arg Gly Gln Ser Glu Lys Trp Trp Ser Gly Leu Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  857
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  857

Cys Ala Arg Gly Arg Gly Gln Gln Trp Leu Thr Gly Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  858
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  858

Cys Ala Arg Gly Arg Arg Leu Val Arg Phe Thr Val Thr Ser Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  859
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  859

Cys Ala Arg Gly Arg Val Trp Ser Ser Arg Asp Tyr Trp 
1               5                   10              


<210>  860
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  860

Cys Ala Arg Gly Ser Gly Ile Ala Ala Ser Gly Ser Tyr Trp 
1               5                   10                  


<210>  861
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  861

Cys Ala Arg Gly Ser Gly Tyr Asp Phe Phe Asp Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  862
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  862

Cys Ala Arg Gly Ser Ser Gly Tyr Tyr Val Ala Trp 
1               5                   10          


<210>  863
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  863

Cys Ala Arg Gly Ser Ser Ser Trp Tyr Asp Trp 
1               5                   10      


<210>  864
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  864

Cys Ala Arg Gly Ser Tyr Trp 
1               5           


<210>  865
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  865

Cys Ala Arg Gly Thr Phe Asp Trp Leu Leu Ser Pro Ser Tyr Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  866
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  866

Cys Ala Arg Gly Thr Phe Leu Glu Trp Leu Leu Thr Asn Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  867
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  867

Cys Ala Arg Gly Thr Gly Gly Phe Asp Tyr Trp 
1               5                   10      


<210>  868
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  868

Cys Ala Arg Gly Val Val Gly Ser Gly Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  869
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  869

Cys Ala Arg Gly Val Trp Thr Thr Pro Met Gly Gly Gly Gly Asn Trp 
1               5                   10                  15      


Phe Asp Pro Trp 
            20  


<210>  870
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  870

Cys Ala Arg Gly Val Tyr Pro Tyr Ser Ser Lys His Lys Pro Ser Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Gly Met Asp Val Trp 
            20                  


<210>  871
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  871

Cys Ala Arg Gly Trp Ala Gly Phe Asp Tyr Trp 
1               5                   10      


<210>  872
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  872

Cys Ala Arg Gly Trp Thr Thr Ile Ser Ser Leu Gly Val Trp 
1               5                   10                  


<210>  873
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  873

Cys Ala Arg Gly Tyr Gly Asp Tyr Val Trp Gly Glu Asn Tyr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  874
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  874

Cys Ala Arg Gly Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10          


<210>  875
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  875

Cys Ala Arg His Ala Gly Phe Tyr Gly Leu Ala Asp Tyr Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  876
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  876

Cys Ala Arg His Gly Arg Ile Ala Ala Asp Ile Trp 
1               5                   10          


<210>  877
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  877

Cys Ala Arg His Asn Pro Gly Tyr Met Gly Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  878
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  878

Cys Ala Arg His Val Tyr Gly Ser Gly Thr Tyr Asn Asn Trp Phe Asp 
1               5                   10                  15      


Pro Trp 
        


<210>  879
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  879

Cys Ala Arg His Tyr Tyr Gly Ser Gly Asn Tyr Arg Asp Trp 
1               5                   10                  


<210>  880
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  880

Cys Ala Arg His Tyr Tyr Gly Ser Gly Ser Tyr Pro Asp Trp 
1               5                   10                  


<210>  881
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  881

Cys Ala Arg Ile Gly Ala Gly Gly Ala Phe Asp Ile Trp 
1               5                   10              


<210>  882
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  882

Cys Ala Arg Ile Gly Ile Ala Val Ala Ala Pro Val Asp His Trp 
1               5                   10                  15  


<210>  883
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  883

Cys Ala Arg Ile Pro Lys Pro Arg Gly Tyr Ser Tyr Gly Asp Asn Gly 
1               5                   10                  15      


Ser Trp 
        


<210>  884
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  884

Cys Ala Arg Lys Val Lys Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Gly 
1               5                   10                  15      


Tyr Trp 
        


<210>  885
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  885

Cys Ala Arg Leu Ala Phe Asp Ile Trp 
1               5                   


<210>  886
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  886

Cys Ala Arg Leu Asp Pro Gly Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  887
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  887

Cys Ala Arg Leu Gly Ser Thr Pro Asp Tyr Trp 
1               5                   10      


<210>  888
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  888

Cys Ala Arg Leu Pro Arg Arg Ser Gly Lys Gly Ser Ala Phe Asp Ile 
1               5                   10                  15      


Trp 
    


<210>  889
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  889

Cys Ala Arg Leu Pro Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Gly Gly 
1               5                   10                  15      


Arg Thr Gly Phe Asp Tyr Trp 
            20              


<210>  890
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  890

Cys Ala Arg Leu Ser Val Trp Lys Trp Glu Gln Val Thr Asn Trp Phe 
1               5                   10                  15      


Asp Pro Trp 
            


<210>  891
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  891

Cys Ala Arg Leu Ser Tyr Tyr Tyr Asp Ser Ser Gly Pro Lys Gly Asp 
1               5                   10                  15      


Ala Phe Asp Ile Trp 
            20      


<210>  892
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  892

Cys Ala Arg Leu Thr Gly Gly Ala Val Ala Gly Thr His Arg Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  893
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  893

Cys Ala Arg Leu Val Val Arg Gly Gly Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  894
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  894

Cys Ala Arg Met Lys Asp Trp Phe Gly Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  895
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  895

Cys Ala Arg Met Ser Ser Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Arg 
1               5                   10                  15      


Arg Gly Met Asp Val Trp 
            20          


<210>  896
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  896

Cys Ala Arg Asn Gly Ile Ala Ala Ala Glu Asp Tyr Trp 
1               5                   10              


<210>  897
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  897

Cys Ala Arg Asn Asn Phe Leu Arg Ala Phe Asp Ile Trp 
1               5                   10              


<210>  898
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  898

Cys Ala Arg Asn Val Glu Gly Ala Thr Ser Phe Pro Glu Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  899
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  899

Cys Ala Arg Pro Ala Gly Ser Ala Gln Asn Trp Phe Asp Pro Trp 
1               5                   10                  15  


<210>  900
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  900

Cys Ala Arg Pro Ile Val Gly Ala Thr Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  901
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  901

Cys Ala Arg Pro Ser Thr Thr Gly Thr Lys Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  902
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  902

Cys Ala Arg Pro Ser Thr Thr Ser Phe Gly Met Asp Val Trp 
1               5                   10                  


<210>  903
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  903

Cys Ala Arg Pro Tyr Ser Ser Ser Arg Gln Gly Asp Tyr Trp 
1               5                   10                  


<210>  904
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  904

Cys Ala Arg Pro Tyr Tyr Tyr Asp Ser Ser Gly Tyr Asp Pro Met Gly 
1               5                   10                  15      


Asp Tyr Trp 
            


<210>  905
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  905

Cys Ala Arg Gln Ala Gly Leu His Cys Ser Ser Thr Ser Cys Tyr Leu 
1               5                   10                  15      


Gly Asn Trp Phe Asp Pro Trp 
            20              


<210>  906
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  906

Cys Ala Arg Gln Ile Gly Trp Glu Leu Met Pro Asp Ile Trp 
1               5                   10                  


<210>  907
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  907

Cys Ala Arg Gln Thr Arg Gly Gly Thr Thr Asp Gly Trp 
1               5                   10              


<210>  908
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  908

Cys Ala Arg Gln Tyr Cys Ser Gly Gly Ser Cys Tyr Pro Asp Ala Phe 
1               5                   10                  15      


Asp Ile Arg 
            


<210>  909
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  909

Cys Ala Arg Gln Tyr Tyr Phe Asp Tyr Trp 
1               5                   10  


<210>  910
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  910

Cys Ala Arg Arg Glu Pro Leu Tyr Ser Ser Arg Arg Gly Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  911
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  911

Cys Ala Arg Arg Gly Tyr Ser Ser Gly Trp Arg Asp Ala Phe Asp Ile 
1               5                   10                  15      


Trp 
    


<210>  912
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  912

Cys Ala Arg Arg Leu Ile Ala Val Ala Gly Ala Glu Phe Asp Pro Trp 
1               5                   10                  15      


<210>  913
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  913

Cys Ala Arg Arg Ser Gly Tyr Ser Gly Ser Val Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  914
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  914

Cys Ala Arg Arg Thr Ala Val Ala Gly Thr Ile Asp Tyr Trp 
1               5                   10                  


<210>  915
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  915

Cys Ala Arg Arg Thr Ser Ala Ser Asp Ile Trp 
1               5                   10      


<210>  916
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  916

Cys Ala Arg Ser Ala Val Ala Gly Ala Phe Asp Ile Trp 
1               5                   10              


<210>  917
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  917

Cys Ala Arg Ser Gly Met Val Lys Trp Leu Arg Ser Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  918
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  918

Cys Ala Arg Ser Gly Pro Ala Ala Met Val Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  919
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  919

Cys Ala Arg Ser Gly Tyr Asn Arg Arg Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  920
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  920

Cys Ala Arg Ser Pro Arg Trp Tyr Asp Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  921
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  921

Cys Ala Arg Ser Gln Ala Thr Gly Glu Arg Phe Asp Tyr Trp 
1               5                   10                  


<210>  922
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  922

Cys Ala Arg Ser Ser Asp Leu Arg Ile Phe Asp Tyr Trp 
1               5                   10              


<210>  923
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  923

Cys Ala Arg Ser Ser Gly Trp Gln Asn Arg Phe Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  924
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  924

Cys Ala Arg Ser Ser Gly Tyr Val Gly Trp Phe Asp Pro Trp 
1               5                   10                  


<210>  925
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  925

Cys Ala Arg Ser Thr Pro Phe Asp Pro Trp 
1               5                   10  


<210>  926
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  926

Cys Ala Arg Ser Val Gly Glu Val Gly Ala Thr Met Leu Gly Ile Gly 
1               5                   10                  15      


Val Trp Tyr Trp Phe Asp Pro Trp 
            20                  


<210>  927
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  927

Cys Ala Arg Ser Tyr Tyr Asp Ser Ser Gly Tyr Pro Arg Lys Asp Ala 
1               5                   10                  15      


Phe Asp Ile Trp 
            20  


<210>  928
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  928

Cys Ala Arg Thr Gly Arg Gly Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  


<210>  929
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  929

Cys Ala Arg Thr Leu Thr Thr Pro Pro Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  930
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  930

Cys Ala Arg Thr Tyr Leu Lys Ala Phe Asp Ile Trp 
1               5                   10          


<210>  931
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  931

Cys Ala Arg Thr Tyr Arg Ile Val Gly Ala Thr Pro Arg Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val Trp 
            20          


<210>  932
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  932

Cys Ala Arg Val Ala Thr Gly Asn Ala Phe Asp Ile Trp 
1               5                   10              


<210>  933
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  933

Cys Ala Arg Val Asp Gly Ser Gly Tyr Tyr Gly Ile Asp Tyr Trp 
1               5                   10                  15  


<210>  934
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  934

Cys Ala Arg Val Phe Pro Leu His Asp Tyr Trp 
1               5                   10      


<210>  935
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  935

Cys Ala Arg Val Gly Ala Thr Ser Ala Gly Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  936
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  936

Cys Ala Arg Val Gly Pro Gly Gly Trp Phe Asp Pro Trp 
1               5                   10              


<210>  937
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  937

Cys Ala Arg Val Gly Arg Gly Tyr Ser Phe Asp Tyr Trp 
1               5                   10              


<210>  938
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  938

Cys Ala Arg Val Gly Trp Leu Arg Phe Leu Asp Tyr Trp 
1               5                   10              


<210>  939
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  939

Cys Ala Arg Val Ile Phe Ser Thr Val Thr Thr Thr Asn Asp Ile Trp 
1               5                   10                  15      


<210>  940
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  940

Cys Ala Arg Val Lys Trp Glu Leu Ala Ile Asp Tyr Trp 
1               5                   10              


<210>  941
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  941

Cys Ala Arg Val Leu Pro Gly Asp Ser Ser Gly Trp Tyr Arg Gly Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
            20                  25  


<210>  942
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  942

Cys Ala Arg Val Met Leu Ile Thr Asp Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  943
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  943

Cys Ala Arg Val Pro Asp Phe Trp Ser Gly Tyr Leu Asp Tyr Trp 
1               5                   10                  15  


<210>  944
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  944

Cys Ala Arg Val Pro Thr Ser Pro Tyr Asp Ile Leu Thr Gly Pro Phe 
1               5                   10                  15      


Asp Tyr Trp 
            


<210>  945
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  945

Cys Ala Arg Val Arg Ala Arg Arg Phe Leu Val Ser Asp Arg Ser Ala 
1               5                   10                  15      


Phe Asp Ile Trp 
            20  


<210>  946
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  946

Cys Ala Arg Val Arg Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Asp 
1               5                   10                  15      


Tyr Phe Asp Tyr Trp 
            20      


<210>  947
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  947

Cys Ala Arg Val Arg Ser Lys Ala Val Ala Gly Thr Leu Pro Lys Arg 
1               5                   10                  15      


Leu Phe Asp Ile Trp 
            20      


<210>  948
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  948

Cys Ala Arg Val Ser Arg Gly Phe Ala Phe Asp Tyr Trp 
1               5                   10              


<210>  949
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  949

Cys Ala Arg Val Thr Leu Gly Ala Ser Val Asp Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  950
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  950

Cys Ala Arg Trp Ala Phe Pro Ile Pro Asn Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  951
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  951

Cys Ala Arg Trp Gly Asp Tyr Gly Asp Leu Tyr Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  952
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  952

Cys Ala Arg Trp Gly Lys Arg Leu Arg Gly Ser Pro Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  953
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  953

Cys Ala Arg Trp Lys Asn Tyr Phe Asp Pro Trp 
1               5                   10      


<210>  954
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  954

Cys Ala Arg Tyr Gly Asp Tyr Gly Asp Tyr Trp 
1               5                   10      


<210>  955
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  955

Cys Ala Arg Tyr Ser Ser Gly Gly Ser Leu Asp Tyr Trp 
1               5                   10              


<210>  956
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  956

Cys Ala Ser Asp Pro Val Thr Ala Ala Thr Arg 
1               5                   10      


<210>  957
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  957

Cys Ala Ser Gly Leu Gly Tyr Phe Asp Tyr Trp 
1               5                   10      


<210>  958
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  958

Cys Ala Ser Lys Thr Thr Ile Asn Ser Gly Trp Ser Arg Glu Tyr His 
1               5                   10                  15      


Tyr Trp 
        


<210>  959
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  959

Cys Ala Ser Pro Thr Gly Met Thr Thr Asn Phe Asp Tyr Trp 
1               5                   10                  


<210>  960
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  960

Cys Ala Ser Pro Thr Val Thr Arg Arg 
1               5                   


<210>  961
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  961

Cys Ala Ser Gln Asn Tyr Tyr Gly Ser Gly Ser Tyr Pro Gly Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  962
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  962

Cys Ala Ser Ser His Tyr Ala Pro Gly Met Asp Val Trp 
1               5                   10              


<210>  963
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  963

Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  964
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  964

Cys Ala Ser Ser Met Val Arg Val Pro Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  965
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  965

Cys Ala Ser Ser Arg Asp Gly Tyr Asn Arg Leu Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  966
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  966

Cys Ala Ser Ser Ser Asp Tyr Gly Asp Tyr Leu Lys Glu Pro Asn Tyr 
1               5                   10                  15      


Gly Met Asp Val Trp 
            20      


<210>  967
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  967

Cys Ala Ser Thr Asp Pro Ser Ser Gly Leu Asp Tyr Trp 
1               5                   10              


<210>  968
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  968

Cys Ala Thr Ala Ser Gly Asp Phe Asp Tyr Trp 
1               5                   10      


<210>  969
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  969

Cys Ala Thr Ala Tyr Arg Arg Pro Gly Gly Leu Asp Val Trp 
1               5                   10                  


<210>  970
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  970

Cys Ala Thr Asp Leu Pro Val Arg Lys Gly Phe Thr Tyr Tyr Asp Ile 
1               5                   10                  15      


Leu Thr Gly Ser Tyr Gly Met Asp Val Trp 
            20                  25      


<210>  971
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  971

Cys Ala Thr Gly Trp Pro Arg Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  972
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  972

Cys Ala Thr Gly Tyr Tyr Tyr Asp Tyr Tyr Phe Asp Tyr Trp 
1               5                   10                  


<210>  973
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  973

Cys Ala Thr His Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  974
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  974

Cys Ala Thr Leu Thr Pro Tyr Gly Thr Val Ala Ser Tyr 
1               5                   10              


<210>  975
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  975

Cys Ala Thr Ser Phe Gly Gly Gly Trp Ile Val Val Asp Thr Ser Leu 
1               5                   10                  15      


Trp Tyr Trp 
            


<210>  976
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  976

Cys Ala Thr Thr Gln Gly Val Tyr Ser Ser Ser Trp Tyr Gly Gly Gly 
1               5                   10                  15      


Arg Ala Phe Asp Ile Trp 
            20          


<210>  977
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  977

Cys Ala Thr Val Gln Thr Asn Tyr Tyr Asp Ser Ser Gly Arg Phe Ser 
1               5                   10                  15      


Tyr Arg Ala His Tyr Phe Asp Tyr Trp 
            20                  25  


<210>  978
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  978

Cys Ala Thr Tyr Gly Asp Phe Gly Tyr Phe Asp Leu Trp 
1               5                   10              


<210>  979
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  979

Cys Glu Val His Asn Phe Gly Ala Thr Tyr Trp 
1               5                   10      


<210>  980
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  980

Cys His Phe Gly Val Ala Ser Val Gly Leu Asn Tyr Trp 
1               5                   10              


<210>  981
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  981

Cys Ile Gly Val Thr Tyr Asn Gly Tyr Thr Ile Gly 
1               5                   10          


<210>  982
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  982

Cys Lys Val His Asn Phe Glu Ala Thr Tyr Trp 
1               5                   10      


<210>  983
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  983

Cys Lys Val His Asn Phe Gly Ala Thr Tyr Trp 
1               5                   10      


<210>  984
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  984

Cys Asn Ala Asp Ser Leu Arg Gly Ile Asp Tyr Trp 
1               5                   10          


<210>  985
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  985

Cys Asn Ala Asp Tyr Gly Thr Trp Tyr Gly Ile Gly Trp 
1               5                   10              


<210>  986
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  986

Cys Asn Ala Gly Ala Pro Ala Trp Thr Tyr Arg Met Gly Thr Tyr Tyr 
1               5                   10                  15      


Pro Gln Phe Gly Ser Trp 
            20          


<210>  987
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  987

Cys Asn Ala Leu Ala Pro Gly Val Arg Gly Ser Trp 
1               5                   10          


<210>  988
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  988

Cys Asn Ala Arg Leu Asp Ala Val Tyr Gly His Ser Arg Tyr Asp Ser 
1               5                   10                  15      


Trp 
    


<210>  989
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  989

Cys Asn Ala Arg Leu Ser Phe Ala Gly Gly Met Gly Tyr Trp 
1               5                   10                  


<210>  990
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  990

Cys Asn Ala Val Cys Lys Phe Gly Thr Thr His Trp 
1               5                   10          


<210>  991
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  991

Cys Asn Ala Val Asn Gly Arg Leu Asn Tyr Trp 
1               5                   10      


<210>  992
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  992

Cys Asn Ala Val Ser Thr Asp Trp Thr Arg Asp Tyr Trp 
1               5                   10              


<210>  993
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  993

Cys Asn Ala Val Thr Tyr Asn Gly Tyr Ser Ile Trp 
1               5                   10          


<210>  994
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  994

Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp 
1               5                   10          


<210>  995
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  995

Cys Asn Ala Val Trp Lys Phe Gly Thr Thr His Trp 
1               5                   10          


<210>  996
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  996

Cys Asn Ala Trp Val Leu Val Ala Gly Ser Arg Gly Thr Ser Ala Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  997
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  997

Cys Asn Gly Val Thr Tyr Asn Gly Tyr Thr Ile Trp 
1               5                   10          


<210>  998
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  998

Cys Asn Leu Ala Gln Arg Gly Glu Thr Tyr Trp 
1               5                   10      


<210>  999
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  999

Cys Asn Met Gly Leu Gly Tyr Ser Glu Tyr Arg Pro Leu Gly Tyr Trp 
1               5                   10                  15      


<210>  1000
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1000

Cys Asn Met Arg Gly Asn Trp Tyr Arg Glu Gly Arg Pro Ala Glu Phe 
1               5                   10                  15      


Leu Ser Trp 
            


<210>  1001
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1001

Cys Asn Arg Val Gly Ser Arg Glu Tyr Ser Tyr Trp 
1               5                   10          


<210>  1002
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1002

Cys Asn Ser Phe Pro Leu Arg Leu His Asp Trp 
1               5                   10      


<210>  1003
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1003

Cys Asn Thr Gly Ile Pro Met Leu Tyr Trp 
1               5                   10  


<210>  1004
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1004

Cys Asn Thr Val Thr Tyr Asn Ala Gly Cys Tyr Lys Lys Tyr Trp 
1               5                   10                  15  


<210>  1005
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1005

Cys Asn Thr Val Thr Tyr Thr Gly Gly Ser Tyr Lys Asn Tyr Trp 
1               5                   10                  15  


<210>  1006
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1006

Cys Asn Val Ile Thr Ile Val Arg Gly Met Gly Pro Arg Ala Tyr Trp 
1               5                   10                  15      


<210>  1007
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1007

Cys Asn Val Leu Ala Gln Asn Asp Gly Asp Tyr Arg Thr Tyr Gly 
1               5                   10                  15  


<210>  1008
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1008

Cys Asn Val Leu Ala Gln Asn Asp Gly Asp Tyr Arg Thr Tyr Trp 
1               5                   10                  15  


<210>  1009
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1009

Cys Arg Val Asp Ala Phe Asp Ile Trp 
1               5                   


<210>  1010
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1010

Cys Ser Ala Asp Lys Leu Asp Tyr Leu Asp Asp Gln Pro Phe Lys Thr 
1               5                   10                  15      


Trp Asp Tyr Trp 
            20  


<210>  1011
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1011

Cys Thr Asp Glu Glu Ser Trp 
1               5           


<210>  1012
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1012

Cys Thr Ile Leu Pro Ala Ala Ala Ala Gly Thr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  1013
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1013

Cys Thr Arg Asp Leu Tyr Gly Gly Tyr Arg Asp Tyr Trp 
1               5                   10              


<210>  1014
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1014

Cys Thr Arg Gly Asn Trp Asn Val Gly Leu Ala Asn Trp 
1               5                   10              


<210>  1015
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1015

Cys Thr Arg Gly Ser Arg Ile Gly Trp Phe Asp Pro Trp 
1               5                   10              


<210>  1016
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1016

Cys Thr Arg Pro Tyr Asp Ala Phe Asp Ile Trp 
1               5                   10      


<210>  1017
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1017

Cys Thr Arg Thr Ile Val Gly Ala Thr Pro His Tyr Trp 
1               5                   10              


<210>  1018
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1018

Cys Thr Ser Ser Phe Leu Thr Gly Ser Gln Pro Ser Gly Tyr Trp 
1               5                   10                  15  


<210>  1019
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1019

Cys Thr Thr Asp Leu Arg Tyr Asp Ser Ser Gly Pro Ala Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  1020
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1020

Cys Thr Thr Asp Pro Leu Glu Leu Pro Trp Tyr Trp 
1               5                   10          


<210>  1021
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1021

Cys Thr Thr Asp Arg Arg Tyr Ser Thr Tyr Phe Asp Leu Trp 
1               5                   10                  


<210>  1022
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1022

Cys Thr Thr Gly Leu Phe Pro Tyr Tyr Arg Tyr Asn Trp Asn Asn Asp 
1               5                   10                  15      


Ala Phe Asp Ile Trp 
            20      


<210>  1023
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1023

Cys Thr Thr Pro Asn Tyr Tyr Asp Ser Arg 
1               5                   10  


<210>  1024
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1024

Cys Thr Thr Arg Thr Tyr Asp Ser Ser Gly Tyr Tyr Glu Thr Gln Asn 
1               5                   10                  15      


Tyr Tyr Met Asp Val Trp 
            20          


<210>  1025
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1025

Cys Thr Thr Thr Glu Tyr Ser Ser Ser Pro Asp Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  1026
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1026

Cys Thr Thr Thr Thr Val Thr Thr Ser Trp 
1               5                   10  


<210>  1027
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1027

Cys Val Lys Asp Arg Ala Trp Gly Phe Asp Tyr Trp 
1               5                   10          


<210>  1028
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1028

Cys Val Lys Phe Gly Met Asn Leu Gly Tyr Ser Gly Tyr Asp Tyr Trp 
1               5                   10                  15      


<210>  1029
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1029

Cys Val Arg Asp Leu Arg Pro Ser Gly Asp Leu Asn Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  1030
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1030

Cys Trp Gly Gly Ser Tyr Tyr Gly Asp Tyr Trp 
1               5                   10      


<210>  1031
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1031

Cys Trp Thr Gly Leu Leu Trp Phe Gly Glu Ser Thr Asp Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  1032
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1032

Cys Tyr Leu Glu Gly Pro Leu Asp Val Tyr Trp 
1               5                   10      


<210>  1033
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1033

Asn Phe Ile Lys Tyr Val Phe Ala Asn 
1               5                   


<210>  1034
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1034

Pro Arg Leu Asp Tyr Trp 
1               5       


<210>  1035
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1035

Gly Leu Ser Ser Gly Ser Val Ser Thr Asn Tyr Tyr Pro Ser 
1               5                   10                  


<210>  1036
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1036

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  1037
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1037

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  1038
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1038

Gln Ala Asn Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  1039
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1039

Gln Ala Ser His Asp Ile Asn Ile Ala Leu Asn 
1               5                   10      


<210>  1040
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1040

Gln Ala Ser Gln Asp Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  1041
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1041

Gln Ala Ser Gln Asp Ile Gly Lys Tyr Leu Asn 
1               5                   10      


<210>  1042
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1042

Gln Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn 
1               5                   10      


<210>  1043
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1043

Gln Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  1044
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1044

Gln Ala Ser Gln Asp Ile Ser His Tyr Leu Asn 
1               5                   10      


<210>  1045
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1045

Gln Ala Ser Gln Asp Ile Ser Asn Arg Leu Asn 
1               5                   10      


<210>  1046
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1046

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  1047
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1047

Gln Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  1048
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1048

Gln Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      


<210>  1049
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1049

Gln Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 
1               5                   10      


<210>  1050
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1050

Gln Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  1051
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1051

Gln Ala Thr Gln Asn Ile Lys Lys Tyr Leu Asn 
1               5                   10      


<210>  1052
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1052

Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala Ser 
1               5                   10      


<210>  1053
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1053

Gln Thr Ser Gln Asp Ile Asn Asn Asn Leu Asn 
1               5                   10      


<210>  1054
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1054

Arg Ala Ile Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  1055
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1055

Arg Ala Ser Glu Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  1056
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1056

Arg Ala Ser Glu Ser Val Ser Ser Ser Ser Phe Ala 
1               5                   10          


<210>  1057
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1057

Arg Ala Ser His Asp Ile Gly Thr Phe Leu Ala 
1               5                   10      


<210>  1058
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1058

Arg Ala Ser Gln Ala Ile Ser Asn Ser Leu Ala 
1               5                   10      


<210>  1059
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1059

Arg Ala Ser Gln Ala Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  1060
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1060

Arg Ala Ser Gln Ala Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  1061
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1061

Arg Ala Ser Gln Asp Ile Gly Ser Phe Leu Ala 
1               5                   10      


<210>  1062
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1062

Arg Ala Ser Gln Asp Ile Arg Asp Glu Leu Ala 
1               5                   10      


<210>  1063
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1063

Arg Ala Ser Gln Asp Ile Arg Ser Ala Leu Ala 
1               5                   10      


<210>  1064
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1064

Arg Ala Ser Gln Asp Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  1065
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1065

Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  1066
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1066

Arg Ala Ser Gln Asp Val Asp Thr Trp Leu Ala 
1               5                   10      


<210>  1067
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1067

Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  1068
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1068

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Ala 
1               5                   10      


<210>  1069
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1069

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  1070
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1070

Arg Ala Ser Gln Gly Ile Arg Ser Asp Leu Ala 
1               5                   10      


<210>  1071
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1071

Arg Ala Ser Gln Gly Ile Ser Asn Asn Ile Asn 
1               5                   10      


<210>  1072
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1072

Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 
1               5                   10      


<210>  1073
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1073

Arg Ala Ser Gln Gly Ile Ser Asn Trp Leu Ala 
1               5                   10      


<210>  1074
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1074

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  1075
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1075

Arg Ala Ser Gln Gly Ile Ser Arg Thr Leu Glx 
1               5                   10      


<210>  1076
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1076

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  1077
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1077

Arg Ala Ser Gln Gly Ile Thr Lys Ser Leu Ala 
1               5                   10      


<210>  1078
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1078

Arg Ala Ser Gln Gly Val Gly Asp Tyr Leu Ala 
1               5                   10      


<210>  1079
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1079

Arg Ala Ser Gln Gly Val Ser Thr Glx Leu Ser 
1               5                   10      


<210>  1080
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1080

Arg Ala Ser Gln Asn Ile Gly Ser Arg Leu Ala 
1               5                   10      


<210>  1081
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1081

Arg Ala Ser Gln Asn Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  1082
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1082

Arg Ala Ser Gln Asn Val Asn Asp Trp Leu Ala 
1               5                   10      


<210>  1083
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1083

Arg Ala Ser Gln Arg Val Gly Asn Asn Leu Ala 
1               5                   10      


<210>  1084
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1084

Arg Ala Ser Gln Ser Ile Gly Arg Trp Leu Ala 
1               5                   10      


<210>  1085
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1085

Arg Ala Ser Gln Ser Ile Gly Ser Asn Leu Asp 
1               5                   10      


<210>  1086
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1086

Arg Ala Ser Gln Ser Ile Gly Ser Asn Leu Asn 
1               5                   10      


<210>  1087
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1087

Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His 
1               5                   10      


<210>  1088
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1088

Arg Ala Ser Gln Ser Ile Gly Thr Tyr Leu Asn 
1               5                   10      


<210>  1089
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1089

Arg Ala Ser Gln Ser Ile Asn Arg Asn Tyr Leu Gly 
1               5                   10          


<210>  1090
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1090

Arg Ala Ser Gln Ser Ile Asn Arg Trp Leu Ala 
1               5                   10      


<210>  1091
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1091

Arg Ala Ser Gln Ser Ile Asn Ser Asn Leu Ala 
1               5                   10      


<210>  1092
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1092

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu Asn 
1               5                   10      


<210>  1093
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1093

Arg Ala Ser Gln Ser Ile Ser Arg Ser Leu Ala 
1               5                   10      


<210>  1094
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1094

Arg Ala Ser Gln Ser Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210>  1095
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1095

Arg Ala Ser Gln Ser Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210>  1096
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1096

Arg Ala Ser Gln Ser Ile Ser Ser His Glx Asn 
1               5                   10      


<210>  1097
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1097

Arg Ala Ser Gln Ser Ile Ser Ser Lys Ser Leu Ala 
1               5                   10          


<210>  1098
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1098

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  1099
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1099

Arg Ala Ser Gln Ser Ile Ser Thr Asn Val Asn 
1               5                   10      


<210>  1100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1100

Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Ala 
1               5                   10      


<210>  1101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1101

Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Ser 
1               5                   10      


<210>  1102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1102

Arg Ala Ser Gln Ser Ile Ser Glx Trp Leu Ala 
1               5                   10      


<210>  1103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1103

Arg Ala Ser Gln Ser Ile Ser Glx Tyr Glx Asn 
1               5                   10      


<210>  1104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1104

Arg Ala Ser Gln Ser Ile Val Ser Tyr Leu Asn 
1               5                   10      


<210>  1105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1105

Arg Ala Ser Gln Ser Ile Glx Glx Tyr Glx Asn 
1               5                   10      


<210>  1106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1106

Arg Ala Ser Gln Ser Leu Arg Ser Lys Leu Ala 
1               5                   10      


<210>  1107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1107

Arg Ala Ser Gln Ser Val Gly Arg Trp Met Ala 
1               5                   10      


<210>  1108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1108

Arg Ala Ser Gln Ser Val Gly Ser Asn Leu Ala 
1               5                   10      


<210>  1109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1109

Arg Ala Ser Gln Ser Val Gly Ser Tyr Leu Ala 
1               5                   10      


<210>  1110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1110

Arg Ala Ser Gln Ser Val Gly Thr Tyr Leu Thr 
1               5                   10      


<210>  1111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1111

Arg Ala Ser Gln Ser Val Asn Asn Thr Tyr Val Ala 
1               5                   10          


<210>  1112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1112

Arg Ala Ser Gln Ser Val Ser Gly Tyr Leu Ala 
1               5                   10      


<210>  1113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1113

Arg Ala Ser Gln Ser Val Ser Arg Lys Leu Ala 
1               5                   10      


<210>  1114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1114

Arg Ala Ser Gln Ser Val Ser Arg Asn Leu Ala 
1               5                   10      


<210>  1115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1115

Arg Ala Ser Gln Ser Val Ser Ser Asp Leu Ala 
1               5                   10      


<210>  1116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1116

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  1117
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1117

Arg Ala Ser Gln Ser Val Ser Ser Asn Gln Leu Ala 
1               5                   10          


<210>  1118
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1118

Arg Ala Ser Gln Ser Val Ser Ser Asn Tyr Leu Ser 
1               5                   10          


<210>  1119
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1119

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ser 
1               5                   10          


<210>  1120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1120

Arg Ala Ser Gln Ser Val Ser Ser Trp Leu Ala 
1               5                   10      


<210>  1121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1121

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  1122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1122

Arg Ala Ser Gln Ser Val Ser Thr Asn Leu Ala 
1               5                   10      


<210>  1123
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1123

Arg Ala Ser Gln Ser Val Ser Thr Ser Tyr Leu Ala 
1               5                   10          


<210>  1124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1124

Arg Ala Ser Gln Ser Val Thr Ser Ser Leu Ala 
1               5                   10      


<210>  1125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1125

Arg Ala Ser Gln Thr Ile Asn Asn Gln Leu Ala 
1               5                   10      


<210>  1126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1126

Arg Ala Ser Gln Thr Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210>  1127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1127

Arg Ala Ser Gln Glx Val Ser Arg Glx Glx Ala 
1               5                   10      


<210>  1128
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1128

Arg Ala Ser Arg Ser Ile Ser Ser Tyr Phe Asn 
1               5                   10      


<210>  1129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1129

Arg Ala Thr Gln Thr Ile Ser Thr Tyr Leu Asn 
1               5                   10      


<210>  1130
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1130

Arg Ser Ser Glu Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  1131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1131

Arg Ser Ser Gln Asn Ile Phe Gln Ser Leu Asn 
1               5                   10      


<210>  1132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1132

Arg Ser Ser Gln Asn Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  1133
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1133

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  1134
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1134

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  1135
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1135

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Tyr Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  1136
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1136

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Phe Asn Tyr Val Asp 
1               5                   10                  15      


<210>  1137
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1137

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  1138
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1138

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  1139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1139

Arg Ser Ser Gln Ser Leu Leu Arg Arg Asn Gly His Asn Tyr Val Asp 
1               5                   10                  15      


<210>  1140
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1140

Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  1141
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1141

Arg Ser Ser Gln Tyr Leu Ser Ser Ala Tyr Leu Ala 
1               5                   10          


<210>  1142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1142

Arg Ser Ser Arg Ser Leu Leu Asp Thr Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  1143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1143

Arg Ser Ser Arg Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  1144
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1144

Arg Ser Ser Arg Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Gln 
1               5                   10                  15      


<210>  1145
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1145

Arg Ser Ser Arg Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Arg 
1               5                   10                  15      


<210>  1146
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1146

Arg Ser Ser Arg Ser Leu Leu His Thr Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  1147
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1147

Arg Ser Ser Arg Ser Leu Leu His Thr Ser Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  1148
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1148

Arg Thr Ser Glu Arg Ser Ser Ile Ser Ser Phe Ala 
1               5                   10          


<210>  1149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1149

Arg Thr Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  1150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1150

Arg Thr Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  1151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1151

Arg Val Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  1152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1152

Ser Gly Asp Lys Leu Gly Lys Lys Tyr Ala Ser 
1               5                   10      


<210>  1153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1153

Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His 
1               5                   10      


<210>  1154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1154

Ser Gly Asp Lys Val Gly His Lys Tyr Ala Ser 
1               5                   10      


<210>  1155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1155

Ser Gly Asn Thr Leu Gly Ser His Tyr Val Ser 
1               5                   10      


<210>  1156
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1156

Ser Gly Ser Ser Ser Asn Ile Gly Ser His Thr Val Ser 
1               5                   10              


<210>  1157
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1157

Ser Gly Thr Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  1158
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1158

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Phe Gly Val His 
1               5                   10                  


<210>  1159
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1159

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Ser Val Ser 
1               5                   10                  


<210>  1160
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1160

Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  1161
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1161

Thr Arg Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  1162
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1162

Thr Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  1163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1163

Glx Ala Cys Leu Arg Ile Ile Ser Tyr Leu Asn 
1               5                   10      


<210>  1164
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1164

Glx Pro Glx Gln Thr Glx Glx Ser His Leu Asn 
1               5                   10      


<210>  1165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1165

Ala Ala Ser Ala Leu Gln Ser 
1               5           


<210>  1166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1166

Ala Ala Ser Asn Leu Glu Thr 
1               5           


<210>  1167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1167

Ala Ala Ser Asn Leu Leu Gly 
1               5           


<210>  1168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1168

Ala Ala Ser Asn Leu Gln Leu 
1               5           


<210>  1169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1169

Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210>  1170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1170

Ala Ala Ser Arg Leu Glu Ser 
1               5           


<210>  1171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1171

Ala Ala Ser Arg Leu Gln Ser 
1               5           


<210>  1172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1172

Ala Ala Ser Arg Arg Ala Thr 
1               5           


<210>  1173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1173

Ala Ala Ser Ser Leu His Thr 
1               5           


<210>  1174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1174

Ala Ala Ser Ser Leu Gln Arg 
1               5           


<210>  1175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1175

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1176

Ala Ala Ser Ser Arg Val Thr 
1               5           


<210>  1177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1177

Ala Ala Ser Thr Leu Glu Ser 
1               5           


<210>  1178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1178

Ala Ala Ser Thr Leu Glu Thr 
1               5           


<210>  1179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1179

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  1180
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1180

Ala Ala Ser Thr Leu Gln Thr 
1               5           


<210>  1181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1181

Ala Ala Ser Thr Ser Gln Ser 
1               5           


<210>  1182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1182

Ala Ser Ser Thr Leu Gln Thr 
1               5           


<210>  1183
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1183

Ala Thr Ser Thr Leu Gln Ser 
1               5           


<210>  1184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1184

Asp Ala Ser Ile Arg Ala Thr 
1               5           


<210>  1185
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1185

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  1186
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1186

Asp Ala Ser Asn Leu Gln Ser 
1               5           


<210>  1187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1187

Asp Ala Ser Asn Arg Ala Ser 
1               5           


<210>  1188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1188

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  1189
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1189

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  1190
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1190

Asp Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1191

Asp Ala Ser Thr Leu Glu Thr 
1               5           


<210>  1192
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1192

Asp Ala Ser Thr Leu Lys Arg 
1               5           


<210>  1193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1193

Asp Ala Ser Thr Leu Gln Thr 
1               5           


<210>  1194
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1194

Asp Thr Ser Asn Arg Ala Thr 
1               5           


<210>  1195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1195

Asp Val Ser Asn Leu Glu Arg 
1               5           


<210>  1196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1196

Asp Val Thr Lys Arg Pro Ser 
1               5           


<210>  1197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1197

Glu Ala Ser Ser Val Ala Ser 
1               5           


<210>  1198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1198

Glu Ala Ser Thr Leu Gln Ser 
1               5           


<210>  1199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1199

Glu Asp Ser Gln Arg Pro Ser 
1               5           


<210>  1200
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1200

Glu Lys Asp Asn Arg Pro Ser Gly 
1               5               


<210>  1201
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1201

Asp Lys Ser Asn Arg Pro Ser Gly 
1               5               


<210>  1202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1202

Glu Asn Asp Lys Arg Pro Ser 
1               5           


<210>  1203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1203

Glu Val Ser Ser Leu Gln Gly 
1               5           


<210>  1204
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1204

Glu Val Ser Ser Val Gln Gly 
1               5           


<210>  1205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1205

Phe Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1206

Phe Gly Ser Tyr Arg Ala Ser 
1               5           


<210>  1207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1207

Gly Ala Ser Asn Leu Gln Ser 
1               5           


<210>  1208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1208

Gly Ala Ser Asn Arg Ala Ser 
1               5           


<210>  1209
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1209

Gly Ala Ser Asn Arg Pro Thr 
1               5           


<210>  1210
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1210

Gly Ala Ser Ser Leu Glu Ser 
1               5           


<210>  1211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1211

Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1212

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  1213
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1213

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  1214
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1214

Gly Ala Ser Thr Leu Gln Arg 
1               5           


<210>  1215
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1215

Gly Ala Ser Thr Leu Gln Ser 
1               5           


<210>  1216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1216

Gly Ala Ser Thr Arg Ala Ala 
1               5           


<210>  1217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1217

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  1218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1218

Gly Ala Ser Thr Val Glu Ser 
1               5           


<210>  1219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1219

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  1220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1220

Gly Asn Ser Ile Arg Pro Ser 
1               5           


<210>  1221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1221

Gly Ser Ser Asn Arg Ala Ala 
1               5           


<210>  1222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1222

Gly Thr Ser Thr Arg Ala Thr 
1               5           


<210>  1223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1223

Gly Val Ser Asn Arg Ala Thr 
1               5           


<210>  1224
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1224

Lys Ala Ser Asn Leu Glu Thr 
1               5           


<210>  1225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1225

Lys Ala Ser Ser Leu Glu Asn 
1               5           


<210>  1226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1226

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  1227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1227

Lys Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1228
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1228

Lys Ala Ser Thr Leu Asp Thr 
1               5           


<210>  1229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1229

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  1230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1230

Lys Ile Ser Asn Arg Phe Ser 
1               5           


<210>  1231
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1231

Leu Ala Ser Arg Arg Ala Ser 
1               5           


<210>  1232
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1232

Leu Gly Phe Asn Arg Ala Ser 
1               5           


<210>  1233
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1233

Leu Gly Ser Asp Arg Ala Ser 
1               5           


<210>  1234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1234

Leu Gly Ser Asp Arg Thr Ser 
1               5           


<210>  1235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1235

Leu Gly Ser His Arg Ala Ser 
1               5           


<210>  1236
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1236

Leu Gly Ser Lys Arg Ala Ser 
1               5           


<210>  1237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1237

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  1238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1238

Met Gly Ser Asn Arg Ala Pro 
1               5           


<210>  1239
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1239

Met Gly Ser Tyr Arg Ala Ser 
1               5           


<210>  1240
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1240

Met Leu Ser Ser Arg Ala Pro 
1               5           


<210>  1241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1241

Asn Thr Ser Asn Arg Ala Thr 
1               5           


<210>  1242
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1242

Pro Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1243
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1243

Gln Ala Ser Asn Leu Glu Ser 
1               5           


<210>  1244
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1244

Gln Ala Ser Ser Leu Asp Ser 
1               5           


<210>  1245
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1245

Gln Ala Ser Ser Leu Ile Ser 
1               5           


<210>  1246
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1246

Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210>  1247
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1247

Arg Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1248
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1248

Arg Ala Ser Thr Leu Glu Ser 
1               5           


<210>  1249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1249

Arg Ala Ser Thr Leu Gln Ser 
1               5           


<210>  1250
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1250

Arg Thr Ser Thr Leu Glu Ser 
1               5           


<210>  1251
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1251

Arg Val Ser Ser Arg Phe Ser 
1               5           


<210>  1252
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1252

Ser Ala Ser Asn Leu Gln Ser 
1               5           


<210>  1253
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1253

Ser Ala Ser Arg Leu Gln Ile 
1               5           


<210>  1254
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1254

Ser Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1255
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1255

Ser Asp Arg Asn Arg Pro Ser 
1               5           


<210>  1256
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1256

Ser Asn Tyr Gln Arg Pro Ser 
1               5           


<210>  1257
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1257

Ser Thr Asn Thr Arg Ser Ser 
1               5           


<210>  1258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1258

Thr Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1259

Thr Leu Ser His Arg Ala Ser 
1               5           


<210>  1260
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1260

Tyr Ala Ser Gln Ser Val Ser 
1               5           


<210>  1261
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1261

Tyr Ala Ser Ser Leu Gln Asn 
1               5           


<210>  1262
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1262

Tyr Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1263
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1263

Tyr Thr Asn Thr Arg Ser Ser 
1               5           


<210>  1264
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1264

Glx Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1265
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1265

Cys Ala Ala Trp Asp Gly Ser Leu Phe Gly His Trp Val Phe 
1               5                   10                  


<210>  1266
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1266

Cys Phe Ser Tyr Ala Gly Ser Arg Phe 
1               5                   


<210>  1267
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1267

Cys Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val Phe 
1               5                   10              


<210>  1268
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1268

Cys His Gln Ser Gly Arg Val Pro Val Thr Phe 
1               5                   10      


<210>  1269
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1269

Cys His Gln Ser Tyr Ser Ile Pro Arg Thr Phe 
1               5                   10      


<210>  1270
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1270

Cys Ile Gln Asn Thr His Trp Pro Leu Thr Arg 
1               5                   10      


<210>  1271
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1271

Cys Leu Leu Tyr Leu Gly Arg Gly Ile Trp Val Phe 
1               5                   10          


<210>  1272
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1272

Cys Leu Gln Asp Tyr Asn Tyr Pro Phe Thr Phe 
1               5                   10      


<210>  1273
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1273

Cys Leu Gln Asp Tyr Ser Tyr Pro Arg Thr Phe 
1               5                   10      


<210>  1274
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1274

Cys Leu Gln Asp Tyr Ser Tyr Pro Tyr Thr Phe 
1               5                   10      


<210>  1275
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1275

Cys Leu Gln His His Ser Tyr Pro Phe Thr Phe 
1               5                   10      


<210>  1276
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1276

Cys Leu Gln His Lys Ser Phe Pro Thr Phe 
1               5                   10  


<210>  1277
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1277

Cys Leu Gln His Asn Gly Tyr Pro Ile Thr Phe 
1               5                   10      


<210>  1278
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1278

Cys Leu Gln His Asn Ser Leu Pro Phe Thr Phe 
1               5                   10      


<210>  1279
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1279

Cys Met His Gly Leu His Pro Pro Phe Thr Phe 
1               5                   10      


<210>  1280
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1280

Cys Met Gln Ala Leu Gln Ile Pro Pro Thr Phe 
1               5                   10      


<210>  1281
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1281

Cys Met Gln Ala Leu Gln Thr Pro Leu Thr Phe 
1               5                   10      


<210>  1282
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1282

Cys Met Gln Ala Leu Gln Thr Pro Gln Thr Phe 
1               5                   10      


<210>  1283
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1283

Cys Met Gln Ala Thr Gln Phe Pro His Thr Phe 
1               5                   10      


<210>  1284
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1284

Cys Met Gln Ala Thr Gln Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1285

Cys Met Gln Gly Leu Gln Thr Pro His Thr Phe 
1               5                   10      


<210>  1286
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1286

Cys Met Gln Gly Leu Gln Thr Pro Trp Thr Phe 
1               5                   10      


<210>  1287
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1287

Cys Met Gln Gly Thr His Trp Pro Leu Thr Phe 
1               5                   10      


<210>  1288
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1288

Cys Met Gln Gly Thr His Trp Pro Pro Thr Phe 
1               5                   10      


<210>  1289
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1289

Cys Met Gln Gly Thr His Trp Pro Tyr Thr Phe 
1               5                   10      


<210>  1290
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1290

Cys Met Gln Gly Thr Arg Trp Pro Thr Phe 
1               5                   10  


<210>  1291
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1291

Cys Met Gln Asn Leu Gln Thr Pro Trp Thr Phe 
1               5                   10      


<210>  1292
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1292

Cys Met Gln Asn Thr His Trp Pro Leu Thr Leu 
1               5                   10      


<210>  1293
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1293

Cys Met Gln Asn Thr His Trp Pro Leu Thr Arg 
1               5                   10      


<210>  1294
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1294

Cys Met Gln Arg Leu Glu Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  1295
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1295

Cys Met Gln Ser Ile Gln Leu Pro Trp Thr Phe 
1               5                   10      


<210>  1296
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1296

Cys Met Gln Ser Leu Gln Ser Pro Leu Thr Phe 
1               5                   10      


<210>  1297
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1297

Cys Met Gln Ser Leu Gln Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  1298
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1298

Cys Met Gln Ser Ser His Trp Pro Lys Thr Phe 
1               5                   10      


<210>  1299
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1299

Cys Met Gln Thr Leu Lys Ala Pro Leu Thr Phe 
1               5                   10      


<210>  1300
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1300

Cys Asn Ser Arg Asp Asn Ser Gly Lys His Lys Val Phe 
1               5                   10              


<210>  1301
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1301

Cys Gln Ala Trp Asp Ser Ser Thr Asp Val Val Phe 
1               5                   10          


<210>  1302
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1302

Cys Gln Glu Ser Tyr Ser Ser Pro Tyr Thr Phe 
1               5                   10      


<210>  1303
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1303

Cys Gln His Leu Asn Asn Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1304
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1304

Cys Gln His Leu Asn Ser Tyr Pro Pro Gly Asp Thr Phe 
1               5                   10              


<210>  1305
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1305

Cys Gln His Arg Ala Asn Trp Pro Gln Thr Phe 
1               5                   10      


<210>  1306
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1306

Cys Gln His Arg Asn Phe Phe 
1               5           


<210>  1307
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1307

Cys Gln His Arg Thr Ser Trp Pro Leu Thr Phe 
1               5                   10      


<210>  1308
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1308

Cys Gln His Tyr Asn Asn Trp Pro Phe Thr Phe 
1               5                   10      


<210>  1309
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1309

Cys Gln His Tyr Tyr Asn Leu Pro Leu Thr Phe 
1               5                   10      


<210>  1310
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1310

Cys Gln Lys Tyr Asn Arg Ala Pro Phe Thr Phe 
1               5                   10      


<210>  1311
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1311

Cys Gln Gln Ala Asp Ser Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1312
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1312

Cys Gln Gln Ala Asp Ser Phe Pro Pro Thr Phe 
1               5                   10      


<210>  1313
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1313

Cys Gln Gln Ala Asp Thr Phe Pro Phe Thr Phe 
1               5                   10      


<210>  1314
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1314

Cys Gln Gln Ala Asp Thr Phe Pro Pro Thr Phe 
1               5                   10      


<210>  1315
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1315

Cys Gln Gln Ala Ile Ser Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1316
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1316

Cys Gln Gln Ala Asn Ser Phe Pro Ile Thr Phe 
1               5                   10      


<210>  1317
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1317

Cys Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1318
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1318

Cys Gln Gln Ala Asn Ser Phe Pro Val Thr Phe 
1               5                   10      


<210>  1319
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1319

Cys Gln Gln Ala Asn Ser Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  1320
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1320

Cys Gln Gln Ala Asn Ser Tyr Pro Leu Thr Phe 
1               5                   10      


<210>  1321
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1321

Cys Gln Gln Ala Asn Thr Phe Pro Phe Thr Phe 
1               5                   10      


<210>  1322
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1322

Cys Gln Gln Ala Asn Thr Val Pro Phe Thr Phe 
1               5                   10      


<210>  1323
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1323

Cys Gln Gln Ala Tyr Ser Phe Pro Gln Thr Phe 
1               5                   10      


<210>  1324
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1324

Cys Gln Gln Ala Tyr Ser Phe Pro Trp Thr Phe 
1               5                   10      


<210>  1325
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1325

Cys Gln Gln Gly Phe Asn Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1326
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1326

Cys Gln Gln Gly Asn Asn Phe Pro Phe Thr Phe 
1               5                   10      


<210>  1327
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1327

Cys Gln Gln Gly Asn Asn Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1328
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1328

Cys Gln Gln Gly Tyr Asn Ile Pro Trp Thr Phe 
1               5                   10      


<210>  1329
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1329

Cys Gln Gln Gly Tyr Ser Ala Pro Trp Thr Phe 
1               5                   10      


<210>  1330
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1330

Cys Gln Gln His Asn Ala Tyr Pro Leu Thr Phe 
1               5                   10      


<210>  1331
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1331

Cys Gln Gln Leu Ser Arg Tyr Pro Ser Leu Phe 
1               5                   10      


<210>  1332
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1332

Cys Gln Gln Asn Asp Tyr Leu Pro Leu Thr Phe 
1               5                   10      


<210>  1333
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1333

Cys Gln Gln Asn Tyr Ala Thr Pro Arg Thr Phe 
1               5                   10      


<210>  1334
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1334

Cys Gln Gln Arg Asn Asn Trp Leu Tyr Thr Phe 
1               5                   10      


<210>  1335
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1335

Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe 
1               5                   10      


<210>  1336
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1336

Cys Gln Gln Arg Ser Asn Trp Pro Pro Gln Ile Thr Phe 
1               5                   10              


<210>  1337
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1337

Cys Gln Gln Arg Thr Asn Trp Pro Pro Arg Val Thr Phe 
1               5                   10              


<210>  1338
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1338

Cys Gln Gln Arg Tyr Lys Ser Tyr Thr Phe 
1               5                   10  


<210>  1339
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1339

Cys Gln Gln Arg Tyr Asn Trp Pro Pro Ser Ile Thr Phe 
1               5                   10              


<210>  1340
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1340

Cys Gln Gln Arg Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  1341
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1341

Cys Gln Gln Ser Phe Ile Met Pro Leu Thr Phe 
1               5                   10      


<210>  1342
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1342

Cys Gln Gln Ser Phe Ser Ala Pro Ile Thr Phe 
1               5                   10      


<210>  1343
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1343

Cys Gln Gln Ser Phe Ser Ser Trp Thr Phe 
1               5                   10  


<210>  1344
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1344

Cys Gln Gln Ser His Ile Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  1345
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1345

Cys Gln Gln Ser His Ser Pro Pro Gly Thr Phe 
1               5                   10      


<210>  1346
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1346

Cys Gln Gln Ser His Ser Ser Pro Arg Thr Phe 
1               5                   10      


<210>  1347
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1347

Cys Gln Gln Ser Ser Arg Phe Trp Thr Phe 
1               5                   10  


<210>  1348
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1348

Cys Gln Gln Ser Tyr Gly Ala Pro Leu Thr Phe 
1               5                   10      


<210>  1349
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1349

Cys Gln Gln Ser Tyr Asn Ser Pro Ile Thr Phe 
1               5                   10      


<210>  1350
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1350

Cys Gln Gln Ser Tyr Asn Thr Pro Phe Thr Phe 
1               5                   10      


<210>  1351
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1351

Cys Gln Gln Ser Tyr Asn Thr Pro Trp Thr Phe 
1               5                   10      


<210>  1352
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1352

Cys Gln Gln Ser Tyr Asn Val Pro Tyr Thr Phe 
1               5                   10      


<210>  1353
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1353

Cys Gln Gln Ser Tyr Arg Thr Pro Leu Thr Phe 
1               5                   10      


<210>  1354
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1354

Cys Gln Gln Ser Tyr Arg Thr Pro Arg Thr Phe 
1               5                   10      


<210>  1355
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1355

Cys Gln Gln Ser Tyr Arg Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  1356
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1356

Cys Gln Gln Ser Tyr Ser Ala Pro Tyr Thr Phe 
1               5                   10      


<210>  1357
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1357

Cys Gln Gln Ser Tyr Ser His Thr Ala Phe Thr Phe 
1               5                   10          


<210>  1358
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1358

Cys Gln Gln Ser Tyr Ser Ile Pro Phe Thr Phe 
1               5                   10      


<210>  1359
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1359

Cys Gln Gln Ser Tyr Ser Lys Pro Thr Phe 
1               5                   10  


<210>  1360
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1360

Cys Gln Gln Ser Tyr Ser Leu Pro Tyr Thr Phe 
1               5                   10      


<210>  1361
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1361

Cys Gln Gln Ser Tyr Ser Met Pro Gln Thr Phe 
1               5                   10      


<210>  1362
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1362

Cys Gln Gln Ser Tyr Ser Pro Pro Phe Thr Phe 
1               5                   10      


<210>  1363
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1363

Cys Gln Gln Ser Tyr Ser Pro Pro Leu Thr Phe 
1               5                   10      


<210>  1364
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1364

Cys Gln Gln Ser Tyr Ser Pro Pro Pro Tyr Thr Phe 
1               5                   10          


<210>  1365
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1365

Cys Gln Gln Ser Tyr Ser Ser Pro Leu Thr Phe 
1               5                   10      


<210>  1366
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1366

Cys Gln Gln Ser Tyr Ser Ser Pro Pro Thr Phe 
1               5                   10      


<210>  1367
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1367

Cys Gln Gln Ser Tyr Ser Thr Pro Ala Phe Thr Phe 
1               5                   10          


<210>  1368
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1368

Cys Gln Gln Ser Tyr Ser Thr Pro Phe Thr Phe 
1               5                   10      


<210>  1369
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1369

Cys Gln Gln Ser Tyr Ser Thr Pro His Thr Phe 
1               5                   10      


<210>  1370
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1370

Cys Gln Gln Ser Tyr Ser Thr Pro Leu Ala Phe 
1               5                   10      


<210>  1371
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1371

Cys Gln Gln Ser Tyr Ser Thr Pro Leu Phe Thr Phe 
1               5                   10          


<210>  1372
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1372

Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  1373
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1373

Cys Gln Gln Ser Tyr Ser Thr Pro Arg Thr Phe 
1               5                   10      


<210>  1374
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1374

Cys Gln Gln Ser Tyr Ser Thr Pro Arg Val Thr Phe 
1               5                   10          


<210>  1375
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1375

Cys Gln Gln Ser Tyr Ser Thr Pro Ser Phe 
1               5                   10  


<210>  1376
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1376

Cys Gln Gln Ser Tyr Ser Thr Pro Thr Phe 
1               5                   10  


<210>  1377
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1377

Cys Gln Gln Ser Tyr Ser Thr Pro Val Thr Phe 
1               5                   10      


<210>  1378
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1378

Cys Gln Gln Ser Tyr Ser Thr Pro Trp Thr Phe 
1               5                   10      


<210>  1379
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1379

Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  1380
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1380

Cys Gln Gln Ser Tyr Ser Val Pro Asp Thr Phe 
1               5                   10      


<210>  1381
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1381

Cys Gln Gln Ser Tyr Thr Ser Thr Pro Leu Asn Ser Phe 
1               5                   10              


<210>  1382
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1382

Cys Gln Gln Ser Tyr Thr Thr Pro Phe Thr Phe 
1               5                   10      


<210>  1383
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1383

Cys Gln Gln Thr Phe Ser Pro Pro Leu Thr Phe 
1               5                   10      


<210>  1384
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1384

Cys Gln Gln Thr Phe Ser Val Pro Trp Thr Phe 
1               5                   10      


<210>  1385
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1385

Cys Gln Gln Thr Asn Leu Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  1386
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1386

Cys Gln Gln Thr Asn Thr Phe Pro Phe Thr Phe 
1               5                   10      


<210>  1387
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1387

Cys Gln Gln Thr Ser Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  1388
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1388

Cys Gln Gln Thr Tyr Asn Ile Pro Ile Thr Phe 
1               5                   10      


<210>  1389
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1389

Cys Gln Gln Thr Tyr Asn Pro Pro Arg Thr Phe 
1               5                   10      


<210>  1390
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1390

Cys Gln Gln Thr Tyr Asn Thr Pro Arg Thr Phe 
1               5                   10      


<210>  1391
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1391

Cys Gln Gln Thr Tyr Ser Ile Pro Phe Thr Phe 
1               5                   10      


<210>  1392
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1392

Cys Gln Gln Thr Tyr Ser Met Pro Ile Thr Phe 
1               5                   10      


<210>  1393
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1393

Cys Gln Gln Thr Tyr Ser Ser Pro Leu Thr Phe 
1               5                   10      


<210>  1394
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1394

Cys Gln Gln Thr Tyr Ser Thr Pro Arg Thr Phe 
1               5                   10      


<210>  1395
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1395

Cys Gln Gln Thr Tyr Ser Thr Pro Thr Thr Phe 
1               5                   10      


<210>  1396
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1396

Cys Gln Gln Thr Tyr Ser Thr Pro Trp Thr Phe 
1               5                   10      


<210>  1397
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1397

Cys Gln Gln Thr Tyr Thr Pro Pro Phe Thr Phe 
1               5                   10      


<210>  1398
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1398

Cys Gln Gln Thr Tyr Thr Thr Pro Arg Phe 
1               5                   10  


<210>  1399
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1399

Cys Gln Gln Val Asn Ser Tyr Pro Pro Thr Phe 
1               5                   10      


<210>  1400
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1400

Cys Gln Gln Tyr Ala Ile Ser Tyr Thr Phe 
1               5                   10  


<210>  1401
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1401

Cys Gln Gln Tyr Ala Asn Ser Pro Trp Thr Phe 
1               5                   10      


<210>  1402
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1402

Cys Gln Gln Tyr Asp Ser Trp Pro Pro Thr Phe 
1               5                   10      


<210>  1403
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1403

Cys Gln Gln Tyr Asp Thr Pro Leu Arg Thr Phe 
1               5                   10      


<210>  1404
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1404

Cys Gln Gln Tyr Asp Thr Ser Pro Pro Thr Phe 
1               5                   10      


<210>  1405
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1405

Cys Gln Gln Tyr Glu Thr Trp Pro Val Leu Thr Phe 
1               5                   10          


<210>  1406
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1406

Cys Gln Gln Tyr Gly Ala Ser Pro Trp Thr Phe 
1               5                   10      


<210>  1407
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1407

Cys Gln Gln Tyr Gly Ile Ala Pro Thr Phe 
1               5                   10  


<210>  1408
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1408

Cys Gln Gln Tyr Gly Ser Ser Pro Ile Thr Phe 
1               5                   10      


<210>  1409
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1409

Cys Gln Gln Tyr Gly Ser Ser Pro Pro Phe Thr Phe 
1               5                   10          


<210>  1410
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1410

Cys Gln Gln Tyr Gly Ser Ser Pro Pro Thr Phe 
1               5                   10      


<210>  1411
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1411

Cys Gln Gln Tyr Gly Ser Ser Pro Thr Phe 
1               5                   10  


<210>  1412
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1412

Cys Gln Gln Tyr Gly Ser Ser Pro Tyr Asn Phe 
1               5                   10      


<210>  1413
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1413

Cys Gln Gln Tyr Gly Ser Ser Pro Tyr Thr Phe 
1               5                   10      


<210>  1414
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1414

Cys Gln Gln Tyr Gly Thr Ser Leu Leu Thr Phe 
1               5                   10      


<210>  1415
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1415

Cys Gln Gln Tyr Lys Asp Trp Pro Thr Phe 
1               5                   10  


<210>  1416
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1416

Cys Gln Gln Tyr Asn Asp Trp Pro Pro Thr Phe 
1               5                   10      


<210>  1417
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1417

Cys Gln Gln Tyr Asn His Trp Pro Pro Leu Phe Thr Phe 
1               5                   10              


<210>  1418
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1418

Cys Gln Gln Tyr Asn Ile Trp Pro Arg Thr Phe 
1               5                   10      


<210>  1419
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1419

Cys Gln Gln Tyr Asn Lys Ser Pro Ser Phe 
1               5                   10  


<210>  1420
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1420

Cys Gln Gln Tyr Asn Asn Trp Pro Pro Asn Tyr Thr Phe 
1               5                   10              


<210>  1421
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1421

Cys Gln Gln Tyr Asn Ser Trp Pro Leu Thr Phe 
1               5                   10      


<210>  1422
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1422

Cys Gln Gln Tyr Asn Thr Phe Pro Ile Thr Phe 
1               5                   10      


<210>  1423
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1423

Cys Gln Gln Tyr Asn Tyr Trp Pro Pro Ala Phe 
1               5                   10      


<210>  1424
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1424

Cys Gln Gln Tyr Ser Asn Trp Pro Phe Thr Phe 
1               5                   10      


<210>  1425
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1425

Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr Ile 
1               5                   10      


<210>  1426
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1426

Cys Gln Gln Tyr Val Ser Tyr Pro Leu Thr Phe 
1               5                   10      


<210>  1427
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1427

Cys Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr Ser 
1               5                   10      


<210>  1428
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1428

Cys Gln Gln Tyr Tyr Thr Tyr Pro Tyr Thr Phe 
1               5                   10      


<210>  1429
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1429

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Ala Ser Val Phe 
1               5                   10              


<210>  1430
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1430

Cys Gln Ser Tyr Asp Tyr Asp His Arg Trp Val Phe 
1               5                   10          


<210>  1431
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1431

Cys Gln Val Trp Asp Ser Ser Thr Val Val Phe 
1               5                   10      


<210>  1432
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1432

Cys Ser Ala Trp Asp Asp Asn Leu Asn Gly Val Val Phe 
1               5                   10              


<210>  1433
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1433

Cys Thr Gln Thr Val Gln Phe Pro Ile Thr Phe 
1               5                   10      


<210>  1434
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1434

Cys Val Gln Thr Thr Gln Ser Pro Leu Thr Phe 
1               5                   10      


<210>  1435
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1435

Ser Ser Phe Ala Gly Asn Ser Leu Glu 
1               5                   


<210>  1436
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1436

Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
1               5                   


<210>  1437
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1437

Phe Ser Phe Ser Ser His Ala Met Ser 
1               5                   


<210>  1438
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1438

Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   


<210>  1439
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1439

Gly Tyr Thr Phe Thr Asn Tyr Asp Ile Asn 
1               5                   10  


<210>  1440
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1440

His Thr Phe Thr Ser His Tyr Met His 
1               5                   


<210>  1441
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1441

Tyr Met Phe Thr Gly His Asp Met His 
1               5                   


<210>  1442
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1442

Tyr Ser Phe Thr Gly Tyr Tyr Leu His 
1               5                   


<210>  1443
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1443

Tyr Ser Phe Thr Asn Tyr Tyr Met His 
1               5                   


<210>  1444
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1444

Tyr Thr Phe Ala Lys Tyr Tyr Ile His 
1               5                   


<210>  1445
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1445

Tyr Thr Phe Asn Gly Tyr Tyr Met His 
1               5                   


<210>  1446
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1446

Tyr Thr Phe Ser Arg His Tyr Ile His 
1               5                   


<210>  1447
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1447

Tyr Thr Phe Thr Asp His Tyr Phe His 
1               5                   


<210>  1448
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1448

Tyr Thr Phe Thr Asp Ser Tyr Ile His 
1               5                   


<210>  1449
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1449

Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   


<210>  1450
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1450

Tyr Thr Phe Thr Gly Tyr Tyr Ile His 
1               5                   


<210>  1451
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1451

Tyr Thr Phe Thr Asn Tyr Tyr Met His 
1               5                   


<210>  1452
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1452

Tyr Thr Phe Thr Arg Tyr Tyr Ile His 
1               5                   


<210>  1453
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1453

Tyr Thr Phe Thr Arg Tyr Tyr Leu His 
1               5                   


<210>  1454
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1454

Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210>  1455
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1455

Tyr Trp Phe Thr Ala Ser Tyr Met His 
1               5                   


<210>  1456
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1456

Gly Thr Phe Ser Ser Tyr Ala Ile Thr 
1               5                   


<210>  1457
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1457

Gly Thr Phe Ser Ser Tyr Gly Ile Ser 
1               5                   


<210>  1458
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1458

Gly Asp Ile Ile Pro Ile Phe Gly Ser Ala Asn Tyr Ala 
1               5                   10              


<210>  1459
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1459

Gly Ile Ile Asn Pro Ser Gly Gly Gly Ala Val Tyr Ala 
1               5                   10              


<210>  1460
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1460

Gly Ile Val Asn Pro Ser Gly Gly Gly Thr Asn Tyr Ala 
1               5                   10              


<210>  1461
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1461

Gly Arg Ile Asn Pro His Asn Gly Asn Thr Asn Tyr Ala 
1               5                   10              


<210>  1462
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1462

Gly Trp Ala Asn Pro Ser Ser Gly Asn Thr Gly Thr Ala 
1               5                   10              


<210>  1463
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1463

Gly Trp Ile Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  1464
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1464

Gly Trp Met Asp Pro Asn Ser Gly Tyr Thr Gly Tyr Ala 
1               5                   10              


<210>  1465
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1465

Gly Trp Met Lys Pro Asp Ser Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  1466
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1466

Gly Trp Met Asn Pro Asn Ser Ala Asn Ala Gly Tyr Ala 
1               5                   10              


<210>  1467
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1467

Gly Trp Met Asn Pro Asn Ser Gly Ser Thr Gly Tyr Ala 
1               5                   10              


<210>  1468
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1468

Ser Ala Ile Ser Gly Ser Gly His Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1469
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1469

Trp Ile Tyr Pro Arg Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  1470
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1470

Cys Ala Asn Pro Lys His Tyr Trp 
1               5               


<210>  1471
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1471

Cys Ala Arg Ala Asn Arg Gly Leu Arg Lys Asn Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  1472
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1472

Cys Ala Arg Ala Thr Arg Val Ser Ala Ala Gly Thr Val His Phe Gln 
1               5                   10                  15      


His Trp 
        


<210>  1473
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1473

Cys Ala Arg Asp His Gly Thr Met Ile Ala Val Ala Gly Thr Phe Asp 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Met Asp Val Trp 
            20                  


<210>  1474
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1474

Cys Ala Arg Glu Asp Asp Phe Trp Ser Gly Gly Gly Met Asp Val Trp 
1               5                   10                  15      


<210>  1475
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1475

Cys Ala Arg Glu Gly Leu Arg Gly Trp Ser Ile Phe Asp Ile Trp 
1               5                   10                  15  


<210>  1476
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1476

Cys Ala Arg Glu Leu Gly Leu Gly Trp Phe Asp Pro Trp 
1               5                   10              


<210>  1477
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1477

Cys Ala Arg Gly Asp Ile Asn Tyr Gly Asn Phe Asp Tyr Trp 
1               5                   10                  


<210>  1478
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1478

Cys Ala Arg Gly Asp Ile Val Ala Thr Met Gly Met Lys Lys Val Asp 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Met Asp Val Trp 
            20                  


<210>  1479
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1479

Cys Ala Arg Gly Gly His Thr Gly Tyr Ser Ser Gly Trp Tyr Asn His 
1               5                   10                  15      


Trp 
    


<210>  1480
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1480

Cys Ala Arg Gly Gly Asn Tyr Gly Arg Trp Leu Gln Pro Trp Tyr Phe 
1               5                   10                  15      


Asp Leu Trp 
            


<210>  1481
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1481

Cys Ala Arg Gly Ile Gly Tyr Trp 
1               5               


<210>  1482
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1482

Cys Ala Arg Gly Ile His Gly Asp Tyr Gly Leu Asp Tyr Tyr Tyr Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  1483
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1483

Cys Ala Arg Gly Leu Gly Tyr Phe Asp Leu Trp 
1               5                   10      


<210>  1484
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1484

Cys Ala Arg Gly Met Glu Tyr Trp 
1               5               


<210>  1485
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1485

Cys Ala Arg Gly Pro Ala Asp Phe Trp Ser Gly Tyr Lys Asn Asp Tyr 
1               5                   10                  15      


Phe Asp Phe Trp 
            20  


<210>  1486
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1486

Cys Ala Arg Gly Ser Gly Tyr Phe Asp Leu Trp 
1               5                   10      


<210>  1487
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1487

Cys Ala Arg His Lys Arg His Thr Pro Tyr Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  1488
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1488

Cys Ala Arg Gln Gly Gly Ser Tyr Ser Met Gly Leu Asp Pro Trp 
1               5                   10                  15  


<210>  1489
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1489

Cys Ala Arg Arg Ser Ser Ser Trp Gly Trp Tyr Phe Asp Leu Trp 
1               5                   10                  15  


<210>  1490
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1490

Cys Ala Arg Ser Pro Asp Phe Trp Ser Gly Glu Gly Tyr Phe Asp Leu 
1               5                   10                  15      


Trp 
    


<210>  1491
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1491

Cys Ala Arg Ser Arg Leu Arg Trp Asp Trp Tyr Phe Asp Leu Trp 
1               5                   10                  15  


<210>  1492
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1492

Cys Ala Arg Ser Tyr Tyr Gly Val Ile Asp Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  1493
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1493

Cys Ala Arg Val Gly Asp Tyr Asp Arg Phe Asn Trp Tyr Phe Asp Leu 
1               5                   10                  15      


Trp 
    


<210>  1494
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1494

Cys Ala Arg Val Arg Phe Leu Glu Glu Met Asp Val Trp 
1               5                   10              


<210>  1495
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1495

Cys Ala Arg Trp Thr Thr Val Val Thr Gly Ala Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  1496
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1496

Cys Val Arg Ser Ala Trp Gly Phe Ala Tyr 
1               5                   10  


<210>  1497
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1497

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  1498
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1498

Lys Ser Ser Gln Ser Val Leu His Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  1499
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1499

Arg Ala Ser Gln Ala Ile Gly Arg Arg Leu Ala 
1               5                   10      


<210>  1500
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1500

Arg Ala Ser Gln Asp Ile Ser Asn Asn Leu Asn 
1               5                   10      


<210>  1501
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1501

Arg Ala Ser Gln Asp Ile Ser Arg Gly Leu Gly 
1               5                   10      


<210>  1502
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1502

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Asn 
1               5                   10      


<210>  1503
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1503

Arg Ala Ser Gln Gly Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  1504
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1504

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  1505
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1505

Arg Ala Ser Gln Gly Val Ser Thr Tyr Leu Ala 
1               5                   10      


<210>  1506
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1506

Arg Ala Ser Gln Asn Ile Asn Ser Trp Leu Ala 
1               5                   10      


<210>  1507
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1507

Arg Ala Ser Gln Ser Ile Ala Arg Tyr Leu Asn 
1               5                   10      


<210>  1508
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1508

Arg Ala Ser Gln Ser Ile Gly Asn Tyr Leu Asn 
1               5                   10      


<210>  1509
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1509

Arg Ala Ser Gln Ser Ile Ile Ser Tyr Leu Asn 
1               5                   10      


<210>  1510
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1510

Arg Ala Ser Gln Ser Ile Ser Lys Trp Leu Ala 
1               5                   10      


<210>  1511
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1511

Arg Ala Ser Gln Ser Ile Thr Thr Tyr Leu Asn 
1               5                   10      


<210>  1512
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1512

Arg Ala Ser Gln Ser Leu Ser Ser Trp Leu Ala 
1               5                   10      


<210>  1513
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1513

Arg Ala Ser Gln Thr Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  1514
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  1514

Arg Ala Ser Arg Thr Val Tyr Asn Phe Leu Ala 
1               5                   10      


<210>  1515
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1515

Ala Ala Ser Arg Leu Gln Thr 
1               5           


<210>  1516
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1516

Ala Ala Ser Ser Leu Gln Thr 
1               5           


<210>  1517
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1517

Ala Ala Ser Thr Leu Tyr Arg 
1               5           


<210>  1518
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1518

Asp Ala Ser Asn Leu Gly Thr 
1               5           


<210>  1519
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1519

Asp Ala Ser Asn Leu Arg Thr 
1               5           


<210>  1520
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1520

Asp Ala Ser Thr Leu Gln Ser 
1               5           


<210>  1521
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1521

Gly Ala Ser Ala Leu Arg Ser 
1               5           


<210>  1522
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1522

Gly Ala Ser His Leu Gln Thr 
1               5           


<210>  1523
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1523

Lys Ala Ser Thr Leu His Asn 
1               5           


<210>  1524
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1524

Lys Thr Ser Ser Leu Gln Ser 
1               5           


<210>  1525
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1525

Leu Gly Ser Ser Arg Ala Ser 
1               5           


<210>  1526
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1526

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  1527
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  1527

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  1528
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1528

Cys Leu Gln Tyr Asn Thr Tyr Pro Trp Thr Phe 
1               5                   10      


<210>  1529
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1529

Cys Gln Gln Ala Phe Arg Phe Pro Pro Thr Phe 
1               5                   10      


<210>  1530
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1530

Cys Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1531
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1531

Cys Gln Gln Gly Asp Ser Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  1532
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1532

Cys Gln Gln Ser Phe Arg Leu Pro Leu Thr Phe 
1               5                   10      


<210>  1533
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1533

Cys Gln Gln Ser His Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  1534
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1534

Cys Gln Gln Ser Ser Arg Ile Pro Pro Thr Phe 
1               5                   10      


<210>  1535
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1535

Cys Gln Gln Ser Trp Arg Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  1536
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1536

Cys Gln Gln Ser Tyr Ser Ile Pro Leu Thr Phe 
1               5                   10      


<210>  1537
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1537

Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe 
1               5                   10      


<210>  1538
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1538

Cys Gln Gln Ser Tyr Ser Thr Pro Trp Thr Phe 
1               5                   10      


<210>  1539
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1539

Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Ser Phe 
1               5                   10      


<210>  1540
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1540

Cys Gln Gln Thr Lys Ser Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1541
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1541

Cys Gln Gln Tyr Asp Thr Tyr Trp Thr Phe 
1               5                   10  


<210>  1542
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1542

Cys Gln Gln Tyr Tyr Ser Phe Pro Leu Thr Phe 
1               5                   10      


<210>  1543
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1543

Cys Gln Gln Tyr Tyr Ser Ser Pro Gln Thr Phe 
1               5                   10      


<210>  1544
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1544

Cys Gln Gln Tyr Tyr Ser Thr Pro Phe Thr Phe 
1               5                   10      


<210>  1545
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1545

Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Phe 
1               5                   10      


<210>  1546
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  1546

Gln Gln Tyr Ser Thr Tyr Pro Leu Thr 
1               5                   


<210>  1547
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1547

Asp Thr Phe Ala Asn Tyr Gly Phe Ser 
1               5                   


<210>  1548
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1548

Phe Ala Phe Lys Asp Tyr Tyr Met Thr 
1               5                   


<210>  1549
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1549

Phe Ala Phe Ser Thr Thr Ala Met Ser 
1               5                   


<210>  1550
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1550

Phe Ala Leu Ser Gly Tyr Tyr Met Ser 
1               5                   


<210>  1551
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1551

Phe Pro Phe Arg Tyr Tyr Gly Met Ser 
1               5                   


<210>  1552
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1552

Phe Pro Phe Glx Tyr Tyr Ser Met Asn 
1               5                   


<210>  1553
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1553

Phe Arg Phe Ser Ile Ser Thr Met Gly 
1               5                   


<210>  1554
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1554

Phe Ser Phe Asp Asp Tyr Gly Met Ser 
1               5                   


<210>  1555
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1555

Phe Ser Phe Glu Thr Tyr Gly Met Ser 
1               5                   


<210>  1556
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1556

Phe Ser Phe Asn Thr Phe Gly Ile His 
1               5                   


<210>  1557
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1557

Phe Ser Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210>  1558
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1558

Phe Ser Phe Ser Asp Tyr Tyr Met Ser 
1               5                   


<210>  1559
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1559

Phe Ser Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210>  1560
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1560

Phe Thr Phe Asp Ala Tyr Ala Met His 
1               5                   


<210>  1561
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1561

Phe Thr Phe Asp Asp Tyr Gly Met Ser 
1               5                   


<210>  1562
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1562

Phe Thr Phe Asp Glu Tyr Ala Met His 
1               5                   


<210>  1563
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1563

Phe Thr Phe Asn Ser Tyr Ser Met Asp 
1               5                   


<210>  1564
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1564

Phe Thr Phe Arg Asn Tyr Ala Ile His 
1               5                   


<210>  1565
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1565

Phe Thr Phe Ser Ala His Gly Met His 
1               5                   


<210>  1566
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1566

Phe Thr Phe Ser Asp Phe Ala Met Thr 
1               5                   


<210>  1567
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1567

Phe Thr Phe Ser Asp His Tyr Met Ser 
1               5                   


<210>  1568
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1568

Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   


<210>  1569
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1569

Phe Thr Phe Ser Lys Thr Asp Met His 
1               5                   


<210>  1570
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1570

Phe Thr Phe Ser Asn Ser Asp Met Asn 
1               5                   


<210>  1571
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1571

Phe Thr Phe Ser Asn Tyr Trp Ile His 
1               5                   


<210>  1572
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1572

Phe Thr Phe Ser Arg His Ser Met Asn 
1               5                   


<210>  1573
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1573

Phe Thr Phe Ser Ser His Ser Thr His 
1               5                   


<210>  1574
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1574

Phe Thr Phe Ser Ser Ser Ala Met His 
1               5                   


<210>  1575
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1575

Phe Thr Phe Ser Ser Ser Trp Met His 
1               5                   


<210>  1576
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1576

Phe Thr Phe Ser Ser Tyr Ala Met His 
1               5                   


<210>  1577
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1577

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  1578
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1578

Phe Thr Phe Ser Ser Tyr Asp Met His 
1               5                   


<210>  1579
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1579

Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210>  1580
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1580

Phe Thr Phe Ser Ser Tyr Trp Met His 
1               5                   


<210>  1581
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1581

Phe Thr Phe Ser Ser Glx Glx Met His 
1               5                   


<210>  1582
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1582

Phe Thr Phe Ser Thr Phe Gly Met His 
1               5                   


<210>  1583
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1583

Phe Thr Phe Ser Thr His Ala Phe His 
1               5                   


<210>  1584
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1584

Phe Thr Phe Ser Thr Tyr Gly Met His 
1               5                   


<210>  1585
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1585

Phe Thr Phe Ser Thr Tyr Ser Met Asn 
1               5                   


<210>  1586
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1586

Phe Thr Phe Ser Thr Tyr Tyr Met Ser 
1               5                   


<210>  1587
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1587

Phe Thr Phe Thr Asp Tyr Gly Leu His 
1               5                   


<210>  1588
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1588

Phe Thr Phe Thr Ser Ser Ala Met Gln 
1               5                   


<210>  1589
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1589

Phe Thr Phe Thr Ser Ser Ala Val Gln 
1               5                   


<210>  1590
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1590

Phe Thr Phe Glx Asn Ala Trp Met Ser 
1               5                   


<210>  1591
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1591

Phe Thr Leu Arg Asn His Trp Leu Ser 
1               5                   


<210>  1592
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1592

Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  1593
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1593

Gly Asp Leu Ser Ile Tyr Thr Ile Asn 
1               5                   


<210>  1594
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1594

Gly Ser Phe Ser Asp Tyr Tyr Trp Ser 
1               5                   


<210>  1595
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1595

Gly Ser Phe Ser Gly Tyr Tyr Trp Thr 
1               5                   


<210>  1596
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1596

Gly Ser Leu Ser Gly Tyr Tyr Trp Ser 
1               5                   


<210>  1597
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1597

Gly Thr Phe His Thr Tyr Gly Leu Ser 
1               5                   


<210>  1598
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1598

Gly Thr Phe Asn Ser Asn Ala Ile Ser 
1               5                   


<210>  1599
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1599

Gly Thr Phe Asn Thr His Thr Ile Thr 
1               5                   


<210>  1600
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1600

Gly Thr Phe Ser His Tyr Thr Ile Ser 
1               5                   


<210>  1601
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1601

Gly Thr Phe Ser Arg Tyr His Met Gly 
1               5                   


<210>  1602
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1602

Gly Thr Phe Ser Ser His Ala Ile Asn 
1               5                   


<210>  1603
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1603

Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210>  1604
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1604

Gly Thr Phe Ser Glx Tyr Ala Ile Ser 
1               5                   


<210>  1605
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1605

Gly Thr Ile Ser Asp Tyr Thr Val Ser 
1               5                   


<210>  1606
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1606

His Thr Phe Leu Thr Tyr Asp Ile Asn 
1               5                   


<210>  1607
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1607

His Thr Phe Ser Ser Tyr Ala Met Gly 
1               5                   


<210>  1608
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1608

Ile Ala Phe Arg Tyr Tyr Asp Met Gly 
1               5                   


<210>  1609
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1609

Ile Ser Ser Val Tyr Gly Met Gly 
1               5               


<210>  1610
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1610

Leu Pro Phe Ser Arg Tyr Ala Met Ala 
1               5                   


<210>  1611
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1611

Leu Ser Phe Ser Ser Tyr Ala Met Gly 
1               5                   


<210>  1612
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1612

Leu Ser Ser Gly Arg Pro Phe Ser Ser Tyr Val Met Gly 
1               5                   10              


<210>  1613
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1613

Leu Thr Phe Asp Asp His Ala Met His 
1               5                   


<210>  1614
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1614

Leu Thr Phe Ser Asn Ala Ala Met Ala 
1               5                   


<210>  1615
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1615

Leu Thr Phe Thr Ser His Gly Met Ser 
1               5                   


<210>  1616
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1616

Asn Ile Phe Pro Ile Asp Asp Met Ser 
1               5                   


<210>  1617
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1617

Asn Ile Asn Ser Ile Glu Thr Leu Gly 
1               5                   


<210>  1618
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1618

Arg Ile Phe Ala Ile Tyr Asp Ile Ala 
1               5                   


<210>  1619
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1619

Arg Ile Phe Ala Ile Tyr Asp Met Ala 
1               5                   


<210>  1620
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1620

Arg Ile Phe Ser Ile Tyr Asp Ile Ala 
1               5                   


<210>  1621
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1621

Arg Ile Phe Ser Ile Tyr Asp Met Gly 
1               5                   


<210>  1622
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1622

Arg Leu Leu Ser Tyr Tyr Ala Leu Ala 
1               5                   


<210>  1623
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1623

Arg Arg Phe Thr Thr Tyr Gly Met Gly 
1               5                   


<210>  1624
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1624

Arg Ser Phe Asn Ser Tyr Thr Thr Thr 
1               5                   


<210>  1625
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1625

Arg Ser Phe Asn Ser Tyr Val Ile Gly 
1               5                   


<210>  1626
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1626

Arg Ser Phe Ser Asp Phe Phe Met Gly 
1               5                   


<210>  1627
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1627

Arg Ser Leu Ser Ser Phe Ala Met Gly 
1               5                   


<210>  1628
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1628

Arg Ser Val Ser Ile Tyr Pro Met Gly 
1               5                   


<210>  1629
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1629

Arg Ser Val Ser Ser Tyr Asn Met Gly 
1               5                   


<210>  1630
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1630

Arg Thr Phe Gly Asn Tyr Asp Met Gly 
1               5                   


<210>  1631
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1631

Arg Thr Phe Gly Ser Asp Val Met Gly 
1               5                   


<210>  1632
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1632

Arg Thr Phe Gly Thr Tyr Pro Asn Gly 
1               5                   


<210>  1633
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1633

Arg Thr Phe Asn Ile Asp Asp Met Gly 
1               5                   


<210>  1634
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1634

Arg Thr Phe Asn Ser Gly Thr Met Gly 
1               5                   


<210>  1635
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1635

Arg Thr Phe Asn Thr Tyr Ala Met Gly 
1               5                   


<210>  1636
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1636

Arg Thr Phe Arg Arg Tyr Ala Met Gly 
1               5                   


<210>  1637
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1637

Arg Thr Phe Arg Ser Tyr Thr Met Gly 
1               5                   


<210>  1638
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1638

Arg Thr Phe Ser Asp Tyr Ser Met Ala 
1               5                   


<210>  1639
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1639

Arg Thr Phe Ser Asp Tyr Ser Met Gly 
1               5                   


<210>  1640
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1640

Arg Thr Phe Ser Met Tyr Asp Met Gly 
1               5                   


<210>  1641
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1641

Arg Thr Phe Ser Asn Tyr Ala Val Gly 
1               5                   


<210>  1642
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1642

Arg Thr Phe Ser Arg Tyr Ala Met Ala 
1               5                   


<210>  1643
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1643

Arg Thr Phe Ser Arg Tyr Ala Met Gly 
1               5                   


<210>  1644
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1644

Arg Thr Phe Ser Arg Tyr Val Met Gly 
1               5                   


<210>  1645
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1645

Arg Thr Phe Ser Ser Tyr Ala Met Ala 
1               5                   


<210>  1646
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1646

Arg Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  1647
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1647

Arg Thr Phe Ser Ser Tyr Ala Val Gly 
1               5                   


<210>  1648
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1648

Arg Thr Phe Ser Val Tyr Gly Val Gly 
1               5                   


<210>  1649
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1649

Arg Thr Phe Ser Tyr Tyr Ala Met Gly 
1               5                   


<210>  1650
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1650

Arg Thr Leu Ser Ala Tyr Asp Met Gly 
1               5                   


<210>  1651
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1651

Arg Thr Leu Ser Arg Tyr Ser Met Gly 
1               5                   


<210>  1652
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1652

Arg Thr Leu Ser Ser Phe Ala Met Gly 
1               5                   


<210>  1653
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1653

Arg Val Leu Ser Tyr Tyr Ala Met Ala 
1               5                   


<210>  1654
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1654

Ser Ile Phe Met Ile Asn Thr Met Ala 
1               5                   


<210>  1655
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1655

Ser Ile Phe Arg Leu Gly Thr Met Tyr 
1               5                   


<210>  1656
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1656

Ser Ile Phe Ser Asp Gly Ala Met Gly 
1               5                   


<210>  1657
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1657

Ser Ile Phe Ser Ile Asn Thr Met Gly 
1               5                   


<210>  1658
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1658

Ser Ile Phe Ser Ile Tyr Ala Met Gly 
1               5                   


<210>  1659
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1659

Ser Ile Ser Ser Phe Asn Thr Met Gly 
1               5                   


<210>  1660
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1660

Ser Ile Val Arg Ser Leu Pro Met Ala 
1               5                   


<210>  1661
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1661

Ser Leu Phe Ser Phe Asn Ala Met Gly 
1               5                   


<210>  1662
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1662

Ser Leu Phe Ser Phe Asn Ala Val Gly 
1               5                   


<210>  1663
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1663

Ser Val Phe Thr Thr Phe Ala Lys Gly 
1               5                   


<210>  1664
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1664

Thr Ile Phe Ser Ile Asn Thr Met Gly 
1               5                   


<210>  1665
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1665

Thr Ile Val Ser Ile Tyr Arg Ile Asn 
1               5                   


<210>  1666
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1666

Val Ile Phe Ala Leu Tyr Asp Ile Ala 
1               5                   


<210>  1667
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1667

Val Thr Phe Ser Arg Tyr Pro Ile Ser 
1               5                   


<210>  1668
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1668

Tyr Gly Phe Thr Gly Tyr Tyr Ile His 
1               5                   


<210>  1669
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1669

Tyr Ile Phe Thr Asp Tyr Tyr Met His 
1               5                   


<210>  1670
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1670

Tyr Ser Phe Thr Arg Thr Asp Met His 
1               5                   


<210>  1671
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1671

Tyr Thr Phe Ala Ser Tyr Asp Ile His 
1               5                   


<210>  1672
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1672

Tyr Thr Phe Ser Tyr Arg Tyr Leu His 
1               5                   


<210>  1673
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1673

Tyr Thr Phe Thr Asp Tyr Phe Met Asn 
1               5                   


<210>  1674
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1674

Tyr Thr Phe Thr Gly Tyr Tyr Ile His 
1               5                   


<210>  1675
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1675

Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   


<210>  1676
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1676

Tyr Thr Phe Thr Asn Asn Phe Met His 
1               5                   


<210>  1677
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1677

Tyr Thr Phe Thr Asn Tyr Cys Met His 
1               5                   


<210>  1678
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1678

Tyr Thr Phe Thr Ser Tyr Ala Met Asn 
1               5                   


<210>  1679
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1679

Tyr Thr Phe Thr Ser Tyr Asp Ile Asn 
1               5                   


<210>  1680
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1680

Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   


<210>  1681
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1681

Tyr Thr Phe Thr Tyr Arg Tyr Leu His 
1               5                   


<210>  1682
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1682

Tyr Thr Ile Ser Asn Tyr Tyr Ile His 
1               5                   


<210>  1683
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR1

<400>  1683

Tyr Glx Phe Thr Asp Tyr Tyr Met His 
1               5                   


<210>  1684
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1684

Ala Ala Ile Lys Trp Ser Gly Thr Asn Thr Tyr Tyr Ala 
1               5                   10              


<210>  1685
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1685

Ala Ala Ile Asn Trp Ser Gly Asp Ser Thr Lys Tyr Ala 
1               5                   10              


<210>  1686
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1686

Ala Ala Ile Gln Trp Ser Ala Asp Asn Thr Phe Tyr Ala 
1               5                   10              


<210>  1687
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1687

Ala Ala Ile Arg Gly Ser Ser Gly Ser Thr Phe Tyr Ala 
1               5                   10              


<210>  1688
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1688

Ala Ala Ile Arg Trp Ser Gly Asp Asn Thr Tyr Tyr Ala 
1               5                   10              


<210>  1689
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1689

Ala Ala Ile Arg Trp Ser Gly Gly Gly Thr Tyr Tyr Ala 
1               5                   10              


<210>  1690
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1690

Ala Ala Ile Ser Gly Ser Gly Gly Ser Thr Thr Tyr Ala 
1               5                   10              


<210>  1691
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1691

Ala Ala Ile Ser Gln Ser Gly Tyr Val Arg Tyr Tyr Ala 
1               5                   10              


<210>  1692
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1692

Ala Ala Ile Ser Arg Phe Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1693
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1693

Ala Ala Ile Ser Arg Phe Gly Gly Ser Thr Tyr Tyr Val 
1               5                   10              


<210>  1694
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1694

Ala Ala Ile Ser Arg Asn Gly Asp Lys Ser His Tyr Ser 
1               5                   10              


<210>  1695
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1695

Ala Ala Ile Ser Arg Arg Gly Gly Ile Ile Glu Tyr Gly 
1               5                   10              


<210>  1696
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1696

Ala Ala Ile Ser Arg Ser Gly Ala Asn Thr Ala Tyr Ser 
1               5                   10              


<210>  1697
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1697

Ala Ala Ile Ser Arg Ser Gly Asp Arg Ile Tyr Tyr Ser 
1               5                   10              


<210>  1698
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1698

Ala Ala Ile Ser Arg Ser Gly Gly Ile Tyr Tyr Ala 
1               5                   10          


<210>  1699
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1699

Ala Ala Ile Ser Arg Ser Gly Val Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1700
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1700

Ala Ala Ile Ser Trp Gly Gly Arg Thr Ala Tyr Ala 
1               5                   10          


<210>  1701
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1701

Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Lys Tyr Ala 
1               5                   10              


<210>  1702
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1702

Ala Ala Ile Ser Tyr Ser Gly Gly Ser Thr Lys Tyr Ala 
1               5                   10              


<210>  1703
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1703

Ala Ala Ile Thr Arg Ser Gly Ser Asn Thr Tyr Tyr Ala 
1               5                   10              


<210>  1704
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1704

Ala Ala Ile Thr Trp Asn Gly Arg Ser Ser Asp Tyr Ala 
1               5                   10              


<210>  1705
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1705

Ala Ala Ile Thr Trp Arg Gly Gly Ile Thr Tyr Tyr Ala 
1               5                   10              


<210>  1706
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1706

Ala Ala Ile Thr Trp Arg Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1707
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1707

Ala Ala Val Ser Ala Ser Gly Gly Tyr Thr Trp Tyr Ala 
1               5                   10              


<210>  1708
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1708

Ala Ala Val Thr Trp Arg Ser Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1709
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1709

Ala Gly Ile Arg Trp Ser Gly Ser Thr Leu Tyr Ala 
1               5                   10          


<210>  1710
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1710

Ala Gly Ile Ser Trp Ile Ala Asp Asn Arg Tyr Tyr Ala 
1               5                   10              


<210>  1711
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1711

Ala Gly Ile Thr Arg Gly Gly Ala Thr Thr Tyr Tyr Ser 
1               5                   10              


<210>  1712
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1712

Ala Gly Ile Thr Ser Ser Gly Arg Thr Ile Tyr Ala 
1               5                   10          


<210>  1713
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1713

Ala Gly Met Ser Gly Glu Gly Arg Asn Thr Lys Tyr Arg 
1               5                   10              


<210>  1714
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1714

Ala Leu Thr Gly Trp Gly Asp Gly Ser Thr Thr Tyr Tyr Glu 
1               5                   10                  


<210>  1715
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1715

Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr Ala 
1               5                   10              


<210>  1716
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1716

Ala Asn Met Arg Gly Gly Gly Tyr Met Lys Tyr Ala 
1               5                   10          


<210>  1717
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1717

Ala Arg Ile Gly Trp Asn Gly Gly Ser Ile Val Tyr Ala 
1               5                   10              


<210>  1718
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1718

Ala Arg Ile Ser Arg Gly Asp Gly Tyr Thr Asp Glu Ala 
1               5                   10              


<210>  1719
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1719

Ala Ser Ile Gly Lys Ser Gly Ser Thr Asn Tyr Ala 
1               5                   10          


<210>  1720
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1720

Ala Ser Ile Arg Trp Ser Gly Gln Ser Pro Tyr Tyr Ala 
1               5                   10              


<210>  1721
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1721

Ala Ser Ile Arg Trp Ser Ser Gly Asn Thr Trp Tyr Ala 
1               5                   10              


<210>  1722
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1722

Ala Ser Ile Ser Ser Gly Gly Arg Thr Asn Tyr Ala 
1               5                   10          


<210>  1723
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1723

Ala Ser Ile Ser Ser Gly Ser Arg Thr Asn Tyr Ala 
1               5                   10          


<210>  1724
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1724

Ala Ser Ile Ser Ser Thr Ser Gly Ser Lys Tyr Tyr Ala 
1               5                   10              


<210>  1725
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1725

Ala Ser Ile Thr Ala Ser Ser Asp Arg Thr Phe Tyr Ala 
1               5                   10              


<210>  1726
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1726

Ala Ser Val Ser Trp Arg Tyr Asp Arg Thr Tyr Tyr Thr 
1               5                   10              


<210>  1727
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1727

Ala Thr Ile Asn Asp Ala Gln Arg Tyr Tyr Ala 
1               5                   10      


<210>  1728
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1728

Ala Thr Ile Arg Pro Val Val Ser Glu Thr Thr Tyr Ala 
1               5                   10              


<210>  1729
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1729

Ala Thr Ile Arg Pro Val Val Thr Glu Thr Asp Tyr Ala 
1               5                   10              


<210>  1730
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1730

Ala Thr Ile Arg Pro Val Val Thr Gln Ile Asp Tyr Ala 
1               5                   10              


<210>  1731
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1731

Ala Thr Ile Ser Ala Ser Gly Gly Asn Thr Ala Tyr Ala 
1               5                   10              


<210>  1732
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1732

Ala Thr Ile Ser Arg Ser Gly Gly Asn Thr Tyr Tyr Ala 
1               5                   10              


<210>  1733
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1733

Ala Thr Ile Ser Trp Ser Gly Ser Ser Ala Asn Tyr Glu 
1               5                   10              


<210>  1734
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1734

Ala Thr Met Thr Ser Gly Gly Asn Thr Asn Tyr Ala 
1               5                   10          


<210>  1735
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1735

Ala Thr Val Thr Ser Gly Gly Arg Ile Asn Tyr Ala 
1               5                   10          


<210>  1736
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1736

Ala Val Ile Gly Arg Ser Gly Gly Ile Lys Tyr Tyr Ala 
1               5                   10              


<210>  1737
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1737

Ala Val Ile Ser Gly Gly Arg Thr Gly Tyr Ala 
1               5                   10      


<210>  1738
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1738

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
1               5                   10              


<210>  1739
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1739

Ala Val Ile Ser Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala 
1               5                   10              


<210>  1740
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1740

Ala Val Ile Thr Ser Gly Gly Lys Thr Val Tyr Ala 
1               5                   10          


<210>  1741
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1741

Ala Val Ile Thr Thr Gly Gly Asp Thr Ser Tyr Ser 
1               5                   10          


<210>  1742
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1742

Ala Val Thr Ser Tyr Asp Gly Gly Lys Lys Asn Tyr Ala 
1               5                   10              


<210>  1743
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1743

Ala Tyr Ile Thr Gly Gly Gly Arg Thr Met Asp Gly 
1               5                   10          


<210>  1744
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1744

Gly Ala Ile Ser Arg Ser Gly Asn Asn Thr Tyr Tyr Ala 
1               5                   10              


<210>  1745
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1745

Gly Glu Ile Asn His Ser Gly Ala Thr Asn Tyr Asn 
1               5                   10          


<210>  1746
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1746

Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn 
1               5                   10          


<210>  1747
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1747

Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala 
1               5                   10              


<210>  1748
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1748

Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Tyr Ala 
1               5                   10              


<210>  1749
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1749

Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  1750
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1750

Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  1751
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1751

Gly Gly Ile Ile Pro Val Phe Gly Thr Ala Asp Tyr Ala 
1               5                   10              


<210>  1752
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1752

Gly Gly Ile Ile Pro Val Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  1753
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1753

Gly Gly Ile Arg Trp Ser Gly Gly Thr Thr Leu Tyr Pro 
1               5                   10              


<210>  1754
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1754

Gly Gly Ile Val Pro Ala Tyr Arg Arg Ala Asn Tyr Ala 
1               5                   10              


<210>  1755
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1755

Gly Gly Val Ile Pro Ile Phe Gly Thr Ala Asp Tyr Ala 
1               5                   10              


<210>  1756
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1756

Gly His Val Asp Pro Gly Asp Gly Glu Thr Ile Tyr Ala 
1               5                   10              


<210>  1757
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1757

Gly Ile Ile Asn Pro Ser Asp Gly Ser Thr Ser His Ala 
1               5                   10              


<210>  1758
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1758

Gly Ile Ile Asn Pro Ser Gly Asp Ser Thr Arg Phe Ala 
1               5                   10              


<210>  1759
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1759

Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ile Tyr Ala 
1               5                   10              


<210>  1760
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1760

Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Asn Tyr Ala 
1               5                   10              


<210>  1761
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1761

Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
1               5                   10              


<210>  1762
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1762

Gly Met Ile Asn Pro Ser Gly Gly Ser Thr Thr Tyr Ala 
1               5                   10              


<210>  1763
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1763

Gly Arg Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
1               5                   10              


<210>  1764
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1764

Gly Arg Ile Ile Pro Ile His Gly Ile Ala Asn Tyr Ala 
1               5                   10              


<210>  1765
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1765

Gly Arg Ile Ile Pro Ile Leu Gly Arg Ala Asn Tyr Ala 
1               5                   10              


<210>  1766
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1766

Gly Arg Ile Ile Pro Ile Leu Gly Arg Thr Asn Tyr Ala 
1               5                   10              


<210>  1767
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1767

Gly Arg Ile Ile Pro Ile Leu Gly Ser Thr Asn Tyr Ala 
1               5                   10              


<210>  1768
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1768

Gly Arg Ile Ile Pro Val Leu Lys Ile Thr Asn Tyr Ala 
1               5                   10              


<210>  1769
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1769

Gly Arg Ile Asn Pro Asn Gly Gly Gly Thr Ile Tyr Ala 
1               5                   10              


<210>  1770
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1770

Gly Arg Ile Thr Pro Arg Leu Gly Ile Ala Asn Tyr Ala 
1               5                   10              


<210>  1771
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1771

Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser 
1               5                   10              


<210>  1772
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1772

Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Thr Tyr Ala 
1               5                   10              


<210>  1773
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1773

Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala 
1               5                   10              


<210>  1774
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1774

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
1               5                   10              


<210>  1775
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1775

Gly Trp Ile Ser Ala Asn Asn Gly Asn Thr Asp Tyr Ala 
1               5                   10              


<210>  1776
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1776

Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala 
1               5                   10              


<210>  1777
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  1777

Gly Xaa Val Asn Ala Gly Asn Gly Asn Thr Thr Tyr Ala 
1               5                   10              


<210>  1778
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1778

Gly Tyr Ile Ser Ala Tyr Thr Gly His Thr Ser Tyr Ala 
1               5                   10              


<210>  1779
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1779

Ser Ala Ile Gly Ala Gly Gly Gly Thr Tyr Tyr Ala 
1               5                   10          


<210>  1780
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1780

Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala 
1               5                   10          


<210>  1781
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1781

Ser Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala 
1               5                   10          


<210>  1782
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1782

Ser Ala Ile Gly Thr Gly Gly Gly Thr Glx Tyr Ala 
1               5                   10          


<210>  1783
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1783

Ser Ala Ile Gly Thr Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10          


<210>  1784
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1784

Ser Ala Ile Arg Gly Ser Gly Glu Arg Thr Tyr Tyr Ala 
1               5                   10              


<210>  1785
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1785

Ser Ala Ile Ser Gly Arg Asp Gly Arg Thr Tyr Tyr Ala 
1               5                   10              


<210>  1786
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1786

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1787
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1787

Ser Ala Ile Ser Ser Gly Ser Asp Arg Thr Tyr Tyr Ala 
1               5                   10              


<210>  1788
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1788

Ser Ala Ile Thr Trp Ser Gly Gly Arg Thr Tyr Tyr Ala 
1               5                   10              


<210>  1789
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1789

Ser Gly Ile Arg Trp Ser Gly Gly Thr Ser Tyr Ala 
1               5                   10          


<210>  1790
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1790

Ser Gly Ile Ser Glu Ser Gly Gly Arg Thr Tyr Tyr Ala 
1               5                   10              


<210>  1791
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1791

Ser Gly Ile Ser Glu Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1792
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1792

Ser Gly Ile Ser Gly Ser Gly Gly Arg Thr His Tyr Ala 
1               5                   10              


<210>  1793
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1793

Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1794
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1794

Ser Gly Ile Ser Trp Asn Gly Gly Lys Thr His Tyr Val 
1               5                   10              


<210>  1795
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1795

Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala 
1               5                   10              


<210>  1796
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1796

Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala 
1               5                   10              


<210>  1797
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1797

Ser Gly Ile Ser Trp Asn Ser Gly Thr Thr Gly Tyr Ser 
1               5                   10              


<210>  1798
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1798

Ser Gly Ile Thr Ser Asn Gly Gly Ala Thr Tyr Tyr Ala 
1               5                   10              


<210>  1799
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1799

Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala 
1               5                   10              


<210>  1800
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1800

Ser Met Ile Ser Tyr Asn Gly Gly Arg Ala Phe Tyr Ala 
1               5                   10              


<210>  1801
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1801

Ser Ser Ile Ser Gly Ser Gly Gly Val Thr Tyr Tyr Ala 
1               5                   10              


<210>  1802
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1802

Ser Ser Ile Ser Pro Arg Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1803
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1803

Ser Ser Ile Ser Ser Ser Ser Thr Tyr Ile Arg Tyr Ala 
1               5                   10              


<210>  1804
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1804

Ser Ser Ile Ser Val Ser Ser Gly Thr Thr His Tyr Ala 
1               5                   10              


<210>  1805
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1805

Ser Ser Ile Ser Val Ser Ser Gly Thr Thr His Tyr Ala 
1               5                   10              


<210>  1806
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1806

Ser Thr Ile Asn Pro Gly Gly Leu Ser Lys Ser Tyr Ala 
1               5                   10              


<210>  1807
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1807

Ser Thr Ile Ser Asp Thr Asn Ser Gly Thr Tyr Tyr Ala 
1               5                   10              


<210>  1808
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1808

Ser Thr Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala 
1               5                   10              


<210>  1809
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1809

Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10              


<210>  1810
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1810

Ser Thr Ile Thr Thr Asp Ser Arg Gly Thr Tyr Tyr Ala 
1               5                   10              


<210>  1811
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1811

Ser Thr Leu Ser Gly Asp Ala Asn Asn Ala Tyr Tyr Ala 
1               5                   10              


<210>  1812
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1812

Ser Val Ile Ser Ser Gly Gly Thr Ile Tyr Tyr Ala 
1               5                   10          


<210>  1813
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1813

Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala 
1               5                   10              


<210>  1814
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1814

Ser Tyr Ile Ser Gly Asn Ser Gly Tyr Thr Asn Tyr Ala 
1               5                   10              


<210>  1815
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1815

Ser Tyr Ile Ser Ser Ser Gly Arg Thr Ile Phe Tyr Ala 
1               5                   10              


<210>  1816
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1816

Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala 
1               5                   10              


<210>  1817
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1817

Ser Tyr Ser Ser Gly Asn Ser Gly Tyr Thr Asn Tyr Ala 
1               5                   10              


<210>  1818
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1818

Ser Tyr Val Ser Asp Ser Gly Ser Ser Val Tyr Tyr Ala 
1               5                   10              


<210>  1819
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR2

<400>  1819

Glx His Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala 
1               5                   10              


<210>  1820
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1820

Cys Ala Ala Ala Arg Arg Ser Gly Thr Tyr Asp Ile Gly Gln Tyr Leu 
1               5                   10                  15      


Arg Glu Ser Ala Tyr Val Phe Trp 
            20                  


<210>  1821
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1821

Cys Ala Ala Ala Tyr Ser Tyr Ser Gln Tyr Gly Ser Ser Tyr Ser Tyr 
1               5                   10                  15      


Trp 
    


<210>  1822
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1822

Cys Ala Ala Asp Asp Leu Gly Leu Glu Leu His Tyr Trp 
1               5                   10              


<210>  1823
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1823

Cys Ala Ala Asp Pro Arg Gly Val Thr Leu Pro Arg Ala Thr Ala Tyr 
1               5                   10                  15      


Glu Tyr Trp 
            


<210>  1824
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1824

Cys Ala Ala Asp Arg Ile Glu Asn Tyr Leu Gly Arg Tyr Tyr Asp Pro 
1               5                   10                  15      


Ser Glu Tyr Glu Tyr Trp 
            20          


<210>  1825
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1825

Cys Ala Ala Asp Arg Ile Glu Asn Tyr Leu Gly Arg Tyr Tyr Asp Pro 
1               5                   10                  15      


Ser Glu Tyr Glu Tyr Trp 
            20          


<210>  1826
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1826

Cys Ala Ala Asp Thr Asn Trp Arg Ala Gly Pro Arg Val Gly Ile Asp 
1               5                   10                  15      


Glu Tyr Ala Tyr Trp 
            20      


<210>  1827
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1827

Cys Ala Ala Gly Pro Asn Trp Ser Thr Arg Asn Arg Glu Tyr Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  1828
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1828

Cys Ala Ala Gly Ser Thr Val Val Ala Glu Phe Asn Tyr Trp 
1               5                   10                  


<210>  1829
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1829

Cys Ala Ala Gly Ser Thr Val Val Ala Glu Phe Asn Tyr Trp 
1               5                   10                  


<210>  1830
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1830

Cys Ala Ala Gly Ser Thr Val Val Ala Glu Phe Asn Tyr Trp 
1               5                   10                  


<210>  1831
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1831

Cys Ala Ala Lys Phe Gly Val Leu Ala Thr Thr Glu Ser Arg His Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1832
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1832

Cys Ala Ala Gln Phe Arg Asn Asp Tyr Gly Leu Arg Tyr Gln Ser Thr 
1               5                   10                  15      


Asn Asn Tyr Trp 
            20  


<210>  1833
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1833

Cys Ala Ala Arg Thr Ser Gly Gly Leu Phe His Tyr Arg Arg Ser Asp 
1               5                   10                  15      


His Trp Asp Thr Trp 
            20      


<210>  1834
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1834

Cys Ala Ala Ser Met Glu Ala Met Asn Ser Leu Arg Val Asn Lys Glu 
1               5                   10                  15      


Arg Tyr Tyr Gln Ser Trp 
            20          


<210>  1835
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1835

Cys Ala Ala Ser Met Glu Ala Met Asn Ser Leu Arg Val Asn Lys Glu 
1               5                   10                  15      


Arg Tyr Tyr Gln Ser Trp 
            20          


<210>  1836
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1836

Cys Ala Ala Ser Met Glu Ala Met Asn Ser Leu Arg Val Asn Lys Glu 
1               5                   10                  15      


Arg Tyr Tyr Gln Ser Trp 
            20          


<210>  1837
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1837

Cys Ala Ala Ser Val Tyr Ile Ser Arg Arg Asp Ser Asp Tyr Gly Tyr 
1               5                   10                  15      


Trp 
    


<210>  1838
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1838

Cys Ala Ala Val Phe Thr Gly Arg Phe Tyr Gly Arg Pro Pro Arg Glu 
1               5                   10                  15      


Lys Tyr Asp Tyr Trp 
            20      


<210>  1839
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1839

Cys Ala Ala Val Gln Ala Val Ile Gly Gly Thr Leu Thr Thr Ala Tyr 
1               5                   10                  15      


Asp Tyr Trp 
            


<210>  1840
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1840

Cys Ala Ala Tyr Ser Thr Phe Asn Thr Asp Val Ala Ser Met Lys Pro 
1               5                   10                  15      


Asp Tyr Trp 
            


<210>  1841
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1841

Cys Ala Gly Asp Arg Ser Arg Tyr Leu Tyr Gly Asp Ser Leu Arg Gly 
1               5                   10                  15      


Pro Tyr Gly Tyr Trp 
            20      


<210>  1842
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1842

Cys Ala Ile Val Arg Gly Lys Lys Trp Tyr Phe Asp Leu Trp 
1               5                   10                  


<210>  1843
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1843

Cys Ala Lys Ala Gln Ala Thr Gly Trp Ser Gly Tyr Tyr Thr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1844
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1844

Cys Ala Lys Ala Gln Ala Thr Gly Trp Ser Gly Tyr Tyr Thr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1845
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1845

Cys Ala Lys Asp Asp Phe Ser Leu Tyr Gly Met Asp Val Trp 
1               5                   10                  


<210>  1846
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1846

Cys Ala Lys Asp Gly Thr Asp Gly Arg Phe Asp Pro Trp 
1               5                   10              


<210>  1847
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1847

Cys Ala Lys Asp Leu Gly Ile Gln Leu Pro Asp Tyr Tyr Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  1848
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1848

Cys Ala Lys Asp Leu Gly Arg Ala Ala Ala Gly Ser Met Asp Val Trp 
1               5                   10                  15      


<210>  1849
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1849

Cys Ala Lys Asp Leu Gly Arg Ala Ala Ala Gly Ser Met Asp Val Trp 
1               5                   10                  15      


<210>  1850
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1850

Cys Ala Lys Asp Leu Gly Arg Ala Ala Ala Gly Ser Met Asp Val Trp 
1               5                   10                  15      


<210>  1851
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1851

Cys Ala Lys Asp Met Val His Leu Ile Val Ala Leu Ala Ile Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  1852
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1852

Cys Ala Lys Asp Ser Gly Leu Val 
1               5               


<210>  1853
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1853

Cys Ala Lys Asp Ser Gly Leu Val 
1               5               


<210>  1854
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1854

Cys Ala Lys Asp Ser Gly Asn Tyr Gly Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15      


<210>  1855
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1855

Cys Ala Lys Glu Asp Tyr Asp Ser Ser Gly Tyr Tyr Tyr Tyr Tyr Phe 
1               5                   10                  15      


Gln His Trp 
            


<210>  1856
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1856

Cys Ala Lys Gly Gly Asp Tyr Phe Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1857
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1857

Cys Ala Lys Gly Gly Asp Tyr Phe Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1858
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1858

Cys Ala Lys Gly Gly Asp Tyr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1859
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1859

Cys Ala Lys Gly Gly Arg Asp Gly Tyr Lys Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  1860
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1860

Cys Ala Lys Gly Gly Arg Asp Gly Tyr Lys Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  1861
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1861

Cys Ala Lys Gly Gly Arg Asp Gly Tyr Lys Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  1862
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1862

Cys Ala Lys Gly Gly Arg Asp Gly Tyr Lys Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  1863
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1863

Cys Ala Lys Gly Gly Arg Asp Gly Tyr Lys Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  1864
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1864

Cys Ala Lys Gly Gly Ser Leu Asp Met Asp Val Trp 
1               5                   10          


<210>  1865
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1865

Cys Ala Lys Gly Gly Tyr Glu Leu Asp Tyr Trp 
1               5                   10      


<210>  1866
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1866

Cys Ala Lys Gly Trp Leu Asp Phe Asp Tyr Trp 
1               5                   10      


<210>  1867
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1867

Cys Ala Lys Gly Trp Leu Asp Phe Asp Tyr Trp 
1               5                   10      


<210>  1868
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1868

Cys Ala Lys Ser Ile Ala Ala Ala Gly Thr Gly Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1869
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1869

Cys Ala Lys Ser Ile Ala Ala Ala Gly Thr Gly Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1870
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1870

Cys Ala Lys Thr Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1871
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1871

Cys Ala Lys Val Ala Ser Gly Trp Ser Trp Pro Phe Asp Ile Trp 
1               5                   10                  15  


<210>  1872
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1872

Cys Ala Leu Thr Trp Ala Pro Thr Pro Thr Asn Arg Arg Ser Asp Tyr 
1               5                   10                  15      


Ala Tyr Trp 
            


<210>  1873
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1873

Cys Ala Asn Gly Leu Glu Asp Ala Tyr Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  1874
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1874

Cys Ala Pro Ala Leu Thr Asp Ala Gly Ser Phe Asp Tyr Trp 
1               5                   10                  


<210>  1875
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1875

Cys Ala Pro Tyr Tyr Tyr Asp Lys Ser Ala Lys Pro Leu Arg Ser Tyr 
1               5                   10                  15      


Phe Asp His Trp 
            20  


<210>  1876
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1876

Cys Ala Arg Ala Ala Gly Asn Phe Trp Ser Gly Tyr Tyr Thr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1877
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1877

Cys Ala Arg Ala Ala Gly Asn Phe Trp Ser Gly Tyr Tyr Thr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1878
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1878

Cys Ala Arg Ala Gly Ile Ala Ala Ala Pro Gly Ser Arg Asn Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val Trp 
            20      


<210>  1879
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1879

Cys Ala Arg Ala Gly Thr Asn Trp Gly Gly Trp Tyr Phe Asp Leu Trp 
1               5                   10                  15      


<210>  1880
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1880

Cys Ala Arg Ala Gly Tyr Gly Arg Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15      


<210>  1881
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1881

Cys Ala Arg Ala Gly Tyr Trp Ser Gly Tyr Gly Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1882
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1882

Cys Ala Arg Ala Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  1883
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1883

Cys Ala Arg Ala Thr Gly Ser Gly Trp Tyr Thr Asp Leu Gly Tyr Trp 
1               5                   10                  15      


<210>  1884
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1884

Cys Ala Arg Ala Thr Gly Ser Gly Trp Tyr Thr Asp Leu Gly Tyr Trp 
1               5                   10                  15      


<210>  1885
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1885

Cys Ala Arg Asp Ala Gly Gly Asp Tyr Asp Tyr Trp 
1               5                   10          


<210>  1886
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1886

Cys Ala Arg Asp Ala Ser Gly Gly Ser Thr Gly Trp Tyr Tyr Phe Asp 
1               5                   10                  15      


Ser Trp 
        


<210>  1887
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1887

Cys Ala Arg Asp Ala Ser Gly Gly Ser Thr Gly Trp Tyr Tyr Phe Asp 
1               5                   10                  15      


Ser Trp 
        


<210>  1888
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1888

Cys Ala Arg Asp Asp Gly Leu Gly Gly Met Asp Val Trp 
1               5                   10              


<210>  1889
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1889

Cys Ala Arg Asp Asp Gly Leu Gly Gly Met Asp Val Trp 
1               5                   10              


<210>  1890
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1890

Cys Ala Arg Asp Asp Ser Met Gly Ala Phe Asp Ile Trp 
1               5                   10              


<210>  1891
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1891

Cys Ala Arg Asp Glu Val Glu Gly Gly Met Asp Val Trp 
1               5                   10              


<210>  1892
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1892

Cys Ala Arg Asp Phe Leu Gly Ser Thr Gly Asp Tyr Trp 
1               5                   10              


<210>  1893
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1893

Cys Ala Arg Asp Phe Leu Gly Ser Thr Gly Asp Tyr Trp 
1               5                   10              


<210>  1894
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1894

Cys Ala Arg Asp Gly Gly Ile Arg Asp Phe Asp Tyr Trp 
1               5                   10              


<210>  1895
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1895

Cys Ala Arg Asp His Ser Ser Gly Trp Arg His Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  1896
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1896

Cys Ala Arg Asp Lys Gly Tyr Ala Phe Asp Ile Trp 
1               5                   10          


<210>  1897
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1897

Cys Ala Arg Asp Leu Asp Tyr Trp 
1               5               


<210>  1898
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1898

Cys Ala Arg Asp Leu Gly Gly Thr Ala Asp Tyr Trp 
1               5                   10          


<210>  1899
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1899

Cys Ala Arg Asp Leu Gly Gly Thr Ala Asp Tyr Trp 
1               5                   10          


<210>  1900
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1900

Cys Ala Arg Asp Leu Gly Gly Thr Ala Asp Tyr Trp 
1               5                   10          


<210>  1901
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1901

Cys Ala Arg Asp Leu Arg Asn Trp Gly Ser Pro Tyr Trp Tyr Phe Asp 
1               5                   10                  15      


Leu Trp 
        


<210>  1902
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1902

Cys Ala Arg Asp Gln Asp Tyr Gly Asp Tyr Gly Trp Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  1903
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1903

Cys Ala Arg Asp Gln Asp Tyr Gly Asp Tyr Gly Trp Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  1904
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1904

Cys Ala Arg Asp Arg Glu Gln Gln Ile Leu Asp Tyr Trp 
1               5                   10              


<210>  1905
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1905

Cys Ala Arg Asp Ser Asp Trp Gly Val Val Asp Pro Trp 
1               5                   10              


<210>  1906
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1906

Cys Ala Arg Asp Val Gly Ala Phe Asp Ile Trp 
1               5                   10      


<210>  1907
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1907

Cys Ala Arg Asp Trp Glu Leu Tyr Gly Met Asp Val Trp 
1               5                   10              


<210>  1908
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1908

Cys Ala Arg Asp Trp Gly Ile Ala Ala Ala Gly Asp Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val Trp 
            20      


<210>  1909
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1909

Cys Ala Arg Asp Trp Gly Ile Ala Ala Ala Gly Asp Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val Trp 
            20      


<210>  1910
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1910

Cys Ala Arg Asp Tyr Ser Asp Arg Ser Gly Ile Asp Tyr Trp 
1               5                   10                  


<210>  1911
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1911

Cys Ala Arg Asp Tyr Ser Asp Arg Ser Gly Ile Asp Tyr Trp 
1               5                   10                  


<210>  1912
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1912

Cys Ala Arg Asp Tyr Tyr Gly Ser Gly Ser Tyr Asn Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1913
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1913

Cys Ala Arg Asp Tyr Tyr Gly Ser Gly Ser Tyr Asn Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1914
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1914

Cys Ala Arg Glu Ala Ala Glu Ile Pro Val Gly Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  1915
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1915

Cys Ala Arg Glu Ala Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  1916
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1916

Cys Ala Arg Glu Ala Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  1917
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1917

Cys Ala Arg Glu Glu Gly Val Gly Gly Met Asp Val Trp 
1               5                   10              


<210>  1918
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1918

Cys Ala Arg Glu Glu Arg Gly Ala Thr Gly Arg Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  1919
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1919

Cys Ala Arg Glu Gly Gly Tyr Tyr Phe Asp Tyr Trp 
1               5                   10          


<210>  1920
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1920

Cys Ala Arg Glu Ser Ala Leu Tyr Ser Ser Ser Trp Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val Trp 
            20          


<210>  1921
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1921

Cys Ala Arg Glu Val Ala Val Lys Asp Tyr Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1922
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1922

Cys Ala Arg Glu Tyr Ser Tyr Gly Tyr Phe Arg Tyr Trp 
1               5                   10              


<210>  1923
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1923

Cys Ala Arg Gly Asp Leu Glu Phe Asp Tyr Trp 
1               5                   10      


<210>  1924
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1924

Cys Ala Arg Gly Glu Gln Trp Leu Val Trp Gly Phe Asp Pro Trp 
1               5                   10                  15  


<210>  1925
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1925

Cys Ala Arg Gly Gly Asp Phe Asp Tyr Trp 
1               5                   10  


<210>  1926
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1926

Cys Ala Arg Gly Gly Asp Ser Ser Gly Tyr Tyr Tyr Tyr Ala Phe Asp 
1               5                   10                  15      


Ile Trp 
        


<210>  1927
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1927

Cys Ala Arg Gly Gly Gly Pro Asn Glu His Asp Tyr Tyr Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  1928
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1928

Cys Ala Arg Gly Gly Asn Thr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1929
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1929

Cys Ala Arg Gly Gly Ser Gly Ser Tyr Tyr Tyr Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  1930
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1930

Cys Ala Arg Gly Gly Ser Gly Ser Tyr Tyr Tyr Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  1931
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1931

Cys Ala Arg Gly Gly Ser Gly Trp Ser Asn Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1932
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1932

Cys Ala Arg Gly Gly Tyr Ser Thr Leu Asp Tyr Trp 
1               5                   10          


<210>  1933
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1933

Cys Ala Arg Gly Gly Tyr Ser Thr Leu Asp Tyr Trp 
1               5                   10          


<210>  1934
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1934

Cys Ala Arg Gly Gly Tyr Ser Thr Leu Asp Tyr Trp 
1               5                   10          


<210>  1935
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1935

Cys Ala Arg Gly Leu Tyr Lys Arg Tyr Ser Tyr Gly Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1936
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1936

Cys Ala Arg Gly Asn Leu Asp Phe Asp Tyr Trp 
1               5                   10      


<210>  1937
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1937

Cys Ala Arg Gly Asn Pro Tyr Tyr Phe Asp Tyr Trp 
1               5                   10          


<210>  1938
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1938

Cys Ala Arg Gly Pro Ala Ala Ile Gly Ile Leu Gly Trp Phe Asp Pro 
1               5                   10                  15      


Trp 
    


<210>  1939
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1939

Cys Ala Arg Gly Pro Tyr Tyr Phe Asp Tyr Trp 
1               5                   10      


<210>  1940
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1940

Cys Ala Arg Gly Pro Tyr Tyr Phe Asp Tyr Trp 
1               5                   10      


<210>  1941
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1941

Cys Ala Arg Gly Pro Tyr Tyr Phe Asp Tyr Trp 
1               5                   10      


<210>  1942
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1942

Cys Ala Arg Gly Arg Gly Lys Lys Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1943
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1943

Cys Ala Arg Gly Arg Gly Tyr Ser Tyr Gly Tyr Tyr Ala Phe Asp Ile 
1               5                   10                  15      


Trp 
    


<210>  1944
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1944

Cys Ala Arg Gly Ser Asp Cys Ser Gly Gly Ser Cys Tyr Tyr Ser Phe 
1               5                   10                  15      


Asp Tyr Trp 
            


<210>  1945
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1945

Cys Ala Arg Gly Ser Gly Trp Ser Gly Leu Asp Tyr Trp 
1               5                   10              


<210>  1946
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1946

Cys Ala Arg Gly Ser Gly Tyr Tyr Gly Pro Gly Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1947
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1947

Cys Ala Arg Gly Ser Tyr Gly Met Asp Val Trp 
1               5                   10      


<210>  1948
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1948

Cys Ala Arg Gly Ser Tyr Gly Met Asp Val Trp 
1               5                   10      


<210>  1949
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1949

Cys Ala Arg Gly Thr Thr Gly Lys Gly Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1950
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1950

Cys Ala Arg Gly Val Ser Ser Gly Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1951
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1951

Cys Ala Arg Gly Tyr Gly Asp Tyr Asp Leu Trp 
1               5                   10      


<210>  1952
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1952

Cys Ala Arg Gly Tyr Gly Asp Tyr Asp Leu Trp 
1               5                   10      


<210>  1953
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1953

Cys Ala Arg Gly Tyr Tyr Asp Phe Asp Tyr Trp 
1               5                   10      


<210>  1954
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1954

Cys Ala Arg His Leu Ser Ser Gly Tyr Leu Ser Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1955
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1955

Cys Ala Arg His Leu Ser Ser Gly Tyr Leu Ser Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1956
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1956

Cys Ala Arg His Pro Gly Ser Phe Gly Gly Tyr Ser Tyr Ala Trp Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Gly Met Asp Val Trp 
            20                  


<210>  1957
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1957

Cys Ala Arg His Pro Gly Ser Phe Gly Gly Tyr Ser Tyr Ala Trp Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Gly Met Asp Val Trp 
            20                  


<210>  1958
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1958

Cys Ala Arg Leu Asp Tyr Gly Glu Thr Glu Gly Asn Gly Asp Trp 
1               5                   10                  15  


<210>  1959
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1959

Cys Ala Arg Leu Gly Ser Tyr Gly Ser Pro Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  1960
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1960

Cys Ala Arg Leu Gly Ser Tyr Gly Ser Pro Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  1961
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1961

Cys Ala Arg Leu Gly Ser Tyr Pro Gly Pro Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1962
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1962

Cys Ala Arg Leu Gly Ser Tyr Pro Gly Pro Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  1963
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1963

Cys Ala Arg Arg Gly Gly Asp Val Thr Val Pro Ala Ala Tyr Tyr Ala 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  1964
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1964

Cys Ala Arg Thr Leu Ser Gly Tyr Ser Ser Ser Trp Tyr Val Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1965
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1965

Cys Ala Arg Tyr Ser Gly Tyr Asp Phe Asp Tyr Trp 
1               5                   10          


<210>  1966
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1966

Cys Ala Ser Ala Ala Asp Phe Asp Tyr Trp 
1               5                   10  


<210>  1967
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1967

Cys Ala Ser Ala Ala Asp Phe Asp Tyr Trp 
1               5                   10  


<210>  1968
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1968

Cys Ala Ser Ala Lys Asn Asp Phe Trp Ser Gly Tyr Phe Ala Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  1969
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1969

Cys Ala Ser Asp Ile Val Val Asp Asp Ala Phe Asp Thr Trp 
1               5                   10                  


<210>  1970
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1970

Cys Ala Ser Gly Asp Thr Tyr Asp Leu Tyr Ser Leu Asp Val Trp 
1               5                   10                  15  


<210>  1971
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1971

Cys Ala Ser Gly Ser Tyr Tyr Ser Asp Phe Asp Tyr Trp 
1               5                   10              


<210>  1972
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1972

Cys Ala Ser Gly Ser Tyr Tyr Ser Asp Phe Asp Tyr Trp 
1               5                   10              


<210>  1973
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1973

Cys Ala Ser Gly Tyr Ser Tyr Gly Leu Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1974
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1974

Cys Ala Ser Gly Tyr Ser Tyr Gly Leu Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


Trp 
    


<210>  1975
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1975

Cys Ala Ser Ser Val Val Pro Ala Gly Pro Ala Gly Val Tyr Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  1976
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1976

Cys Ala Ser Ser Val Val Pro Ala Gly Pro Ala Gly Val Tyr Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  1977
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1977

Cys Ala Ser Thr Val Thr Thr Asp Ala Phe Asp Ile Trp 
1               5                   10              


<210>  1978
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1978

Cys Ala Ser Thr Val Thr Thr Asp Ala Phe Asp Ile Trp 
1               5                   10              


<210>  1979
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1979

Cys Ala Ser Tyr Phe Gly Val Met Asp Val Trp 
1               5                   10      


<210>  1980
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1980

Cys Ala Thr Ala Tyr Gly Ser Ser Ser Leu Asn Ile Asp Tyr Trp 
1               5                   10                  15  


<210>  1981
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1981

Cys Ala Thr Ala Tyr Gly Ser Ser Ser Leu Asn Ile Asp Tyr Trp 
1               5                   10                  15  


<210>  1982
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1982

Cys Ala Thr Ala Tyr Gly Ser Ser Ser Leu Asn Ile Asp Tyr Trp 
1               5                   10                  15  


<210>  1983
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1983

Cys Ala Thr Asp Glu Tyr Ser Ser Ser Tyr Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  1984
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1984

Cys Ala Thr Asp Tyr Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  1985
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1985

Cys Ala Thr Glu Ala Ala Leu Asp Ala Phe Asp Ile Trp 
1               5                   10              


<210>  1986
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1986

Cys Ala Thr Glu Ala Ala Leu Asp Ala Phe Asp Ile Trp 
1               5                   10              


<210>  1987
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1987

Cys Ala Thr Gly Pro Asn Ser Ile Tyr 
1               5                   


<210>  1988
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1988

Cys Ala Thr Gly Pro Asn Ser Ile Tyr 
1               5                   


<210>  1989
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1989

Cys Ala Thr Arg Arg Pro Phe Asn Ser Tyr Asn Thr Glu Gln Ser Tyr 
1               5                   10                  15      


Asp Ser Trp 
            


<210>  1990
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1990

Cys Ala Thr Arg Arg Pro Phe Asn Ser Tyr Asn Thr Glu Gln Ser Tyr 
1               5                   10                  15      


Asp Ser Trp 
            


<210>  1991
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1991

Cys Ala Thr Arg Thr Gly Tyr Ser Tyr Gly Phe Asn Phe Trp Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  1992
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1992

Cys Ala Thr Arg Thr Gly Tyr Ser Tyr Gly Phe Asn Phe Trp Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  1993
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1993

Cys Ala Thr Ser Pro Tyr Gly Val Phe Thr Leu Asp Tyr Trp 
1               5                   10                  


<210>  1994
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1994

Cys Ala Thr Ser Pro Tyr Gly Val Phe Thr Leu Asp Tyr Trp 
1               5                   10                  


<210>  1995
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1995

Cys Ala Thr Val Thr Gly Tyr Ser Ser Ala Gly Ala Phe Asp Ile Trp 
1               5                   10                  15      


<210>  1996
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1996

Cys Ala Val Val Asp Asp Ala Phe Asp Ile Trp 
1               5                   10      


<210>  1997
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1997

Cys Ala Val Val Asp Asp Ala Phe Asp Ile Trp 
1               5                   10      


<210>  1998
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1998

Cys Gly Ser Arg Gly Tyr Trp 
1               5           


<210>  1999
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  1999

Cys His Ala Lys Gln Leu Arg Asn Gly Gln Met Tyr Thr Tyr Trp 
1               5                   10                  15  


<210>  2000
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2000

Cys His Ala Val Glu Asn Ile Leu Gly Arg Phe Val Asp Tyr Trp 
1               5                   10                  15  


<210>  2001
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2001

Cys His Gly Arg Asp Tyr Gly Ser Asn Ala Pro Gln Tyr Trp 
1               5                   10                  


<210>  2002
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2002

Cys Lys Ala Ala Pro Arg Trp Gly Gly Ala Thr Ala Tyr Trp 
1               5                   10                  


<210>  2003
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2003

Cys Lys Ile Tyr Gly Leu Asn Gly Gln Pro Leu Gly Ser Trp 
1               5                   10                  


<210>  2004
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2004

Cys Lys Leu Gln Val Arg Pro Ile Gly Tyr Ser Ser Ala Tyr Ser Arg 
1               5                   10                  15      


Asn Tyr Trp 
            


<210>  2005
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2005

Cys Lys Gln His Pro Asn Gly Tyr Arg 
1               5                   


<210>  2006
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2006

Cys Asn Ala Ala Ser Thr Val Thr Ala Trp Pro Tyr Tyr Gly Pro Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  2007
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2007

Cys Asn Ala Ala Ser Thr Val Thr Ala Trp Pro Tyr Tyr Gly Pro Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  2008
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2008

Cys Asn Ala Asp Gly Tyr Ser Trp Asp Gly Arg Ser Gly Arg Arg Leu 
1               5                   10                  15      


Glu Leu Trp 
            


<210>  2009
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2009

Cys Asn Ala Asp Ile Lys Thr Thr Thr Tyr Ser Pro Leu Arg Asn Tyr 
1               5                   10                  15      


Trp 
    


<210>  2010
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2010

Cys Asn Ala Glu Thr Tyr Ser Gly Asn Thr Ile Trp 
1               5                   10          


<210>  2011
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2011

Cys Asn Ala Phe Val Arg Ser Asp Phe Asp Arg Tyr Tyr Asp Tyr Trp 
1               5                   10                  15      


<210>  2012
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2012

Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp 
1               5                   10                  


<210>  2013
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2013

Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp 
1               5                   10                  


<210>  2014
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2014

Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp 
1               5                   10                  


<210>  2015
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2015

Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp 
1               5                   10                  


<210>  2016
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2016

Cys Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr Trp 
1               5                   10                  


<210>  2017
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2017

Cys Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr Trp 
1               5                   10                  


<210>  2018
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2018

Cys Asn Ala Lys Arg Pro Trp Gly Thr Arg Asp Glu Tyr Trp 
1               5                   10                  


<210>  2019
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2019

Cys Asn Ala Asn Tyr Arg Gly Asn Arg Tyr Trp 
1               5                   10      


<210>  2020
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2020

Cys Asn Ala Pro Ala Trp Leu Tyr Asp Asp Asp Tyr Trp 
1               5                   10              


<210>  2021
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2021

Cys Asn Ala Val Thr Phe Gly Gly Asn Thr Ile Arg 
1               5                   10          


<210>  2022
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2022

Cys Asn Ala Val Thr Tyr Asp Gly Tyr 
1               5                   


<210>  2023
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2023

Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Arg 
1               5                   10          


<210>  2024
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2024

Cys Asn Ala Val Val Val Gly Leu Ser Arg Arg Ile Asp Asn Ile Trp 
1               5                   10                  15      


<210>  2025
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2025

Cys Asn Lys Val Asn Ala Ile Thr Lys Leu 
1               5                   10  


<210>  2026
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2026

Cys Asn Leu Arg Glu Trp Asn Asn Ser Gly Ala Gly Tyr Trp 
1               5                   10                  


<210>  2027
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2027

Cys Asn Thr Ser Pro Tyr Met His Asp Val Trp 
1               5                   10      


<210>  2028
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2028

Cys Asn Thr Ser Pro Tyr Met His Asp Val Trp 
1               5                   10      


<210>  2029
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2029

Cys Asn Thr Val Arg Pro Leu Trp Ala Trp 
1               5                   10  


<210>  2030
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2030

Cys Asn Thr Tyr Pro Phe Pro Ile Tyr Lys Lys Gly Tyr Pro Phe Trp 
1               5                   10                  15      


<210>  2031
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2031

Cys Asn Val Asp Arg Thr Leu Tyr Gly Lys Tyr Lys Glu Tyr Trp 
1               5                   10                  15  


<210>  2032
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2032

Cys Ser Lys Gly Gly Val Tyr Gly Gly Thr Tyr Val Pro Asp Ser Trp 
1               5                   10                  15      


<210>  2033
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2033

Cys Ser Lys Gly Gly Val Tyr Gly Gly Thr Tyr Val Pro Asp Ser Trp 
1               5                   10                  15      


<210>  2034
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2034

Cys Ser Ser Arg Gly Tyr Trp 
1               5           


<210>  2035
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2035

Cys Ser Ser Arg Gly Tyr Trp 
1               5           


<210>  2036
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2036

Cys Thr Ala Gly Arg Ser Arg Tyr Leu Tyr Gly Ser Ser Leu Asn Gly 
1               5                   10                  15      


Pro Tyr Asp Tyr Trp 
            20      


<210>  2037
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2037

Cys Thr Lys Gly Gly Ile Gln 
1               5           


<210>  2038
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2038

Cys Thr Leu Val Asn Glu Ile Lys Thr Trp Trp 
1               5                   10      


<210>  2039
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2039

Cys Thr Leu Val Asn Glu Ile Lys Thr Trp Trp 
1               5                   10      


<210>  2040
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2040

Cys Thr Leu Val Asn Glu Ile Lys Thr Trp Trp 
1               5                   10      


<210>  2041
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2041

Cys Thr Leu Val Asn Glu Ile Lys Thr Trp Trp 
1               5                   10      


<210>  2042
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2042

Cys Thr Arg Glu His Ser Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  2043
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2043

Cys Thr Arg Val Ala Trp Gly Leu Asp Tyr Trp 
1               5                   10      


<210>  2044
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2044

Cys Thr Thr Ala Gly Tyr Lys Ala Ala Arg Arg Ser Val Tyr Pro Arg 
1               5                   10                  15      


Ile Phe Asn Phe Asp Tyr Trp 
            20              


<210>  2045
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2045

Cys Thr Thr Asp Asp Tyr Gly Asp Leu Thr His Leu Asp Tyr Trp 
1               5                   10                  15  


<210>  2046
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2046

Cys Thr Thr Asp Asp Tyr Gly Asp Gln Tyr Gly Met Asp Val Trp 
1               5                   10                  15  


<210>  2047
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2047

Cys Thr Thr Asp Leu Trp Asp Tyr Trp 
1               5                   


<210>  2048
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2048

Cys Thr Thr Asp Leu Trp Asp Tyr Trp 
1               5                   


<210>  2049
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2049

Cys Val Lys Asp Gly Gly Ser Phe Pro Leu Ala Tyr Ala Phe Asp Ile 
1               5                   10                  15      


Trp 
    


<210>  2050
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2050

Cys Val Lys Asp Gly Gly Ser Phe Pro Leu Ala Tyr Ala Phe Asp Ile 
1               5                   10                  15      


Trp 
    


<210>  2051
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2051

Cys Val Lys Asp Gly Gly Ser Phe Pro Leu Ala Tyr Ala Phe Asp Ile 
1               5                   10                  15      


Trp 
    


<210>  2052
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2052

Cys Val Arg Gly Asp Ser Gly Trp Gly Ile Leu Tyr Tyr Val Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  2053
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2053

Cys Val Arg Tyr Ala Trp Pro Glu Phe Asp His Trp 
1               5                   10          


<210>  2054
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2054

Cys Val Arg Tyr Ala Trp Pro Glu Phe Asp His Trp 
1               5                   10          


<210>  2055
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2055

Cys Val Arg Tyr Ala Trp Pro Glu Phe Asp His Trp 
1               5                   10          


<210>  2056
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2056

Cys Val Tyr Gly Arg Asp Phe Asp Tyr Trp 
1               5                   10  


<210>  2057
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2057

Cys Tyr Ala Asp Ser Arg Ser Ser Trp Tyr Asp Glu Tyr Leu Glu His 
1               5                   10                  15      


Trp 
    


<210>  2058
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2058

Cys Tyr Ala Asp Ser Arg Ser Ser Trp Tyr Asp Glu Tyr Leu Glu His 
1               5                   10                  15      


Trp 
    


<210>  2059
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2059

Cys Tyr Ala Asn Ile Tyr Tyr Thr Arg Arg Ala Pro Glu Glu Tyr Trp 
1               5                   10                  15      


<210>  2060
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2060

Cys Tyr Ala Arg Thr Gln Arg Met Gly Val Val Asn Ser Tyr Trp 
1               5                   10                  15  


<210>  2061
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2061

Cys Tyr Ala Arg Thr Val Ile Gly Gly Phe Gly Ala Phe Arg Ala His 
1               5                   10                  15      


Trp 
    


<210>  2062
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2062

Cys Tyr Ala Arg Thr Val Ile Gly Gly Phe Gly Ala Phe Arg Ala His 
1               5                   10                  15      


Trp 
    


<210>  2063
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2063

Cys Tyr Ala Arg Thr Val Ile Gly Gly Phe Gly Ala Phe Arg Ala His 
1               5                   10                  15      


Trp 
    


<210>  2064
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2064

Cys Tyr Arg Arg Gln Trp Ala Ser Ser Trp Gly Ala Arg Asn Tyr Glu 
1               5                   10                  15      


Tyr Trp 
        


<210>  2065
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - heavy CDR3

<400>  2065

Cys Tyr Val Lys Leu Arg Asp Asp Asp Tyr Val Tyr Arg 
1               5                   10              


<210>  2066
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2066

Gly Ala Ser Gln Ser Val Pro Arg Asn Ser Leu Ala 
1               5                   10          


<210>  2067
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2067

His Gly Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  2068

<400>  2068
000

<210>  2069
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2069

Lys Ser Ser His Ser Leu Leu Ser Thr Ser Thr Asn Arg Asn His Leu 
1               5                   10                  15      


Ala 
    


<210>  2070
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2070

Lys Ser Ser His Ser Leu Leu Ser Thr Ser Thr Asn Arg Asn Gln Leu 
1               5                   10                  15      


Ala 
    


<210>  2071
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2071

Lys Ser Ser His Ser Leu Leu Tyr Ser Ser Asp Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  2072
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2072

Lys Ser Ser Gln Ser Ile Leu Ser Ser Ser Ser Asn Arg Asp Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  2073
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2073

Lys Ser Ser Gln Ser Val Leu Tyr Thr Thr Thr Asn Arg Asn His Ile 
1               5                   10                  15      


Ala 
    


<210>  2074
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2074

Lys Ser Ser Gln Ser Val Leu Tyr Thr Thr Thr Asn Arg Asn His Ile 
1               5                   10                  15      


Ala 
    


<210>  2075
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2075

Gln Ala Ser Gln Asp Ile Ala Asn Tyr Leu Asn 
1               5                   10      


<210>  2076
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2076

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  2077
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2077

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  2078
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2078

Gln Ala Ser Gln Gly Ile Thr Asn Tyr Leu Asn 
1               5                   10      


<210>  2079
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2079

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  2080
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2080

Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  2081
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2081

Arg Ala Ser Gln Gly Ile Asn Ser Tyr Leu Ala 
1               5                   10      


<210>  2082
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2082

Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 
1               5                   10      


<210>  2083
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2083

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  2084
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2084

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  2085
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2085

Arg Ala Ser Gln Gly Ile Ser Arg Asp Leu Ala 
1               5                   10      


<210>  2086
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2086

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  2087
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2087

Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  2088
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2088

Arg Ala Ser Gln Asn Ile Gly Leu Tyr Leu Asn 
1               5                   10      


<210>  2089
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2089

Arg Ala Ser Gln Arg Val Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  2090
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2090

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  2091
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2091

Arg Ala Ser Gln Ser Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210>  2092
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2092

Arg Ala Ser Gln Ser Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210>  2093
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2093

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  2094
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2094

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  2095
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2095

Arg Ala Ser Gln Ser Ile Glx Asn Tyr Leu Asn 
1               5                   10      


<210>  2096
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2096

Arg Ala Ser Gln Ser Val Arg Ser Ser Asp Leu Ala 
1               5                   10          


<210>  2097
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2097

Arg Ala Ser Gln Ser Val Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  2098
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2098

Arg Ala Ser Gln Tyr Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  2099
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2099

Arg Ala Ser Arg Asn Ile Asn Arg Tyr Leu Asn 
1               5                   10      


<210>  2100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2100

Arg Pro Ser Gln Ser Ile Gly Ser Trp Leu Ala 
1               5                   10      


<210>  2101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2101

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Tyr Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  2102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2102

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  2103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2103

Arg Val Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  2104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2104

Arg Glx Ser Gln Ser Glx Ser Glx Tyr Leu Asn 
1               5                   10      


<210>  2105
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2105

Ser Gly Ser Ser Ser Asn Val Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  2106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR1

<400>  2106

Trp Ala Ser Gln Ser Val Arg Gly Asn Tyr Val Ala 
1               5                   10          


<210>  2107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2107

Ala Ala Ser Ile Leu Gln Ser 
1               5           


<210>  2108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2108

Ala Ala Ser Ser Leu His Ser 
1               5           


<210>  2109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2109

Ala Ala Ser Ser Leu Leu Ser 
1               5           


<210>  2110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2110

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  2111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2111

Ala Ala Ser Thr Leu Glu Ser 
1               5           


<210>  2112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2112

Ala Ala Ser Thr Leu Gln Arg 
1               5           


<210>  2113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2113

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  2114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2114

Asp Ala Lys Gly Leu His Pro 
1               5           


<210>  2115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2115

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  2116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2116

Asp Ala Ser Asn Leu Gln Ser 
1               5           


<210>  2117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2117

Asp Ala Ser Asn Arg Ala Ala 
1               5           


<210>  2118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2118

Asp Ala Ser Asn Arg Ala Gly 
1               5           


<210>  2119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2119

Asp Ala Ser Asn Arg Gln Ser 
1               5           


<210>  2120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2120

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  2121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2121

Asp Ala Ser Ser Leu Gln Arg 
1               5           


<210>  2122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2122

Asp Asn Asp Lys Arg Pro Ser 
1               5           


<210>  2123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2123

Asp Thr Ser Asn Arg Ala Thr 
1               5           


<210>  2124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2124

Gly Ala Ser Gln Arg Ala Thr 
1               5           


<210>  2125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2125

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  2126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2126

Gly Ser Ser Ser Arg Ala Thr 
1               5           


<210>  2127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2127

Gly Ser Ser Thr Leu Gln Ser 
1               5           


<210>  2128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2128

Gly Thr Ser Asn Leu Gln Ser 
1               5           


<210>  2129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2129

Gly Thr Ser Ser Leu His Thr 
1               5           


<210>  2130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2130

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  2131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2131

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  2132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2132

Ser Ala Ser Ser Leu Gln Ser 
1               5           


<210>  2133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2133

Ser Ala Ser Thr Leu Gln Ser 
1               5           


<210>  2134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2134

Thr Leu Ser Tyr Arg Ala Ser 
1               5           


<210>  2135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2135

Trp Ala Ser Ser Arg Lys Ser 
1               5           


<210>  2136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2136

Trp Ser Ser Thr Arg Glu Ser 
1               5           


<210>  2137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2137

Glx Ala Ser Ser Leu Gln Ser 
1               5           


<210>  2138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR2

<400>  2138

Glx Ala Ser Thr Leu Glu Ser 
1               5           


<210>  2139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2139

Cys Glu Ser Trp Asp Ser Ser Leu Ser Ser Glu Val Phe 
1               5                   10              


<210>  2140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2140

Cys Leu Gln Asp Phe Ser Phe Pro Trp Thr Phe 
1               5                   10      


<210>  2141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2141

Cys Leu Gln Asp Tyr Ser Tyr Pro Arg Thr Phe 
1               5                   10      


<210>  2142
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2142

Cys Leu Gln Asp Tyr Thr Asp Pro Phe Thr Phe 
1               5                   10      


<210>  2143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2143

Cys Leu Gln His Asn Ser Tyr Pro Phe Thr Phe 
1               5                   10      


<210>  2144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2144

Cys Met Gln Ala Leu Glu Ala Leu Phe Thr Phe 
1               5                   10      


<210>  2145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2145

Cys Met Gln Ala Leu Gln Thr Pro Ile Thr Phe 
1               5                   10      


<210>  2146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2146

Cys Met Gln Ala Thr Gln Phe Pro Leu Thr Phe 
1               5                   10      


<210>  2147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2147

Cys Gln His Arg Ser Asn Trp Pro Leu Thr Phe 
1               5                   10      


<210>  2148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2148

Cys Gln Gln Ala Asn Ser Phe Pro Pro Thr Phe 
1               5                   10      


<210>  2149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2149

Cys Gln Gln Ala Asn Ser Leu Phe Thr Phe 
1               5                   10  


<210>  2150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2150

Cys Gln Gln Ala Tyr Ser Phe Pro Trp Thr Phe 
1               5                   10      


<210>  2151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2151

Cys Gln Gln Phe Asp Arg Ser Pro Leu Thr Phe 
1               5                   10      


<210>  2152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2152

Cys Gln Gln Gly Asn Ser Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  2153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2153

Cys Gln Gln Gly Tyr Gly Thr Pro Pro Met Phe 
1               5                   10      


<210>  2154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2154

Cys Gln Gln Gly Tyr Asn Thr Pro Arg Thr Phe 
1               5                   10      


<210>  2155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2155

Cys Gln Gln Ile His Ser Tyr Pro Leu Thr Phe 
1               5                   10      


<210>  2156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2156

Cys Gln Gln Ser Phe Ser Thr Pro Arg Thr Phe 
1               5                   10      


<210>  2157
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2157

Cys Gln Gln Ser Asn Ser Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  2158
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2158

Cys Gln Gln Ser Ser Ser Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  2159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2159

Cys Gln Gln Ser Tyr Asp Ser Pro Trp Thr Phe 
1               5                   10      


<210>  2160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2160

Cys Gln Gln Ser Tyr Ile Thr Pro Leu Thr Phe 
1               5                   10      


<210>  2161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2161

Cys Gln Gln Ser Tyr Asn Thr Pro Arg Thr Phe 
1               5                   10      


<210>  2162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2162

Cys Gln Gln Ser Tyr Asn Val Pro Phe Thr Phe 
1               5                   10      


<210>  2163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2163

Cys Gln Gln Ser Tyr Arg Ile His Trp Thr Phe 
1               5                   10      


<210>  2164
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2164

Cys Gln Gln Ser Tyr Arg Thr Pro Leu Thr Phe 
1               5                   10      


<210>  2165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2165

Cys Gln Gln Ser Tyr Arg Tyr Pro Thr Phe 
1               5                   10  


<210>  2166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2166

Cys Gln Gln Ser Tyr Ser Ala Pro Leu Ser Phe 
1               5                   10      


<210>  2167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2167

Cys Gln Gln Ser Tyr Ser Ala Pro Leu Thr Phe 
1               5                   10      


<210>  2168
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2168

Cys Gln Gln Ser Tyr Ser Phe Pro Pro Phe Thr Phe 
1               5                   10          


<210>  2169
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2169

Cys Gln Gln Ser Tyr Ser Ile Pro Phe Thr Phe 
1               5                   10      


<210>  2170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2170

Cys Gln Gln Ser Tyr Ser Leu Pro Leu Thr Phe 
1               5                   10      


<210>  2171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2171

Cys Gln Gln Ser Tyr Ser Met Pro Leu Thr Phe 
1               5                   10      


<210>  2172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2172

Cys Gln Gln Ser Tyr Ser Pro Pro Phe Thr Phe 
1               5                   10      


<210>  2173
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2173

Cys Gln Gln Ser Tyr Ser Ser Pro Pro Thr Phe 
1               5                   10      


<210>  2174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2174

Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  2175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2175

Cys Gln Gln Ser Tyr Ser Thr Pro Trp Thr Phe 
1               5                   10      


<210>  2176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2176

Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  2177
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2177

Cys Gln Gln Ser Tyr Ser Thr Ser Ile Thr Phe 
1               5                   10      


<210>  2178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2178

Cys Gln Gln Ser Tyr Ser Val Pro Tyr Thr Phe 
1               5                   10      


<210>  2179
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2179

Cys Gln Gln Ser Tyr Thr Ser Arg Leu Thr Phe 
1               5                   10      


<210>  2180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2180

Cys Gln Gln Ser Tyr Thr Thr Pro Phe Thr Phe 
1               5                   10      


<210>  2181
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2181

Cys Gln Gln Thr Tyr Ser Ile Pro Pro Thr Phe 
1               5                   10      


<210>  2182
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2182

Cys Gln Gln Thr Tyr Thr Ile Pro Phe Thr Phe 
1               5                   10      


<210>  2183
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2183

Cys Gln Gln Tyr Gly Arg Ser Pro Arg Tyr Ser Phe 
1               5                   10          


<210>  2184
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2184

Cys Gln Gln Tyr His Asn Trp Pro Pro Glu Tyr Thr Phe 
1               5                   10              


<210>  2185
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2185

Cys Gln Gln Tyr Asn Asn Trp Pro Pro Ile Thr Phe 
1               5                   10          


<210>  2186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2186

Cys Gln Gln Tyr Asn Asn Trp Pro Tyr Thr Phe 
1               5                   10      


<210>  2187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2187

Cys Gln Gln Tyr Tyr Asn Ile Pro Tyr Ser Phe 
1               5                   10      


<210>  2188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2188

Cys Gln Gln Tyr Tyr Ser Thr Pro Gln Thr Phe 
1               5                   10      


<210>  2189
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized molecular recognition unit - light CDR3

<400>  2189

Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  2190
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2190

Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
1               5                   10                  15      


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
            20                  25                  30          


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
        35                  40                  45              


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
    50                  55                  60                  


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
65                  70                  75                  80  


Ser Ser Arg Leu His Thr Cys Gln Arg His 
                85                  90  


<210>  2191
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  2191

Lys Met Ser His Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser 
1               5                   10                  15      


Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys 
            20                  25                  30          


Ile Cys Lys Pro Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg 
        35                  40                  45              


Lys Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala 
    50                  55                  60                  


Lys Gly Leu Ser Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys 
65                  70                  75                  80  


Ala Arg Leu His Val Cys Gln Lys 
                85              


<210>  2192
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2192

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr 
    130                 135                 140                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
145                 150                 155                 160 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                165                 170                 175     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            180                 185                 190         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        195                 200                 205             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    210                 215                 220                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
225                 230                 235                 240 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                245                 250                 255     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            260                 265                 270         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys 
        275                 280                 285             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    290                 295                 300                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
305                 310                 315                 320 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                325                 330                 335     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            340                 345                 350         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365             


Gly Gly Ser Gly Ser Ala Val Gln Gln Val Glu Ser Gly Gly Gly Leu 
    370                 375                 380                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
385                 390                 395                 400 


Thr Leu Asp Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
                405                 410                 415     


Lys Arg Glu Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn Tyr 
            420                 425                 430         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        435                 440                 445             


Asn Thr Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
    450                 455                 460                 


Val Tyr Phe Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp Gly 
465                 470                 475                 480 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly His His 
                485                 490                 495     


His His His His 
            500 


<210>  2193
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2193

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Ala Val Gln Gln Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Leu Asp Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Lys Arg Glu Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Phe Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro 
    130                 135                 140                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            180                 185                 190         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        195                 200                 205             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    210                 215                 220                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
225                 230                 235                 240 


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                245                 250                 255     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            260                 265                 270         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
        275                 280                 285             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    290                 295                 300                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
305                 310                 315                 320 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly 
        355                 360                 365             


Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
    370                 375                 380                 


Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe Ala Ile 
385                 390                 395                 400 


Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly Asn Gln Arg Glu Leu 
                405                 410                 415     


Val Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr Ala Asp Ser 
            420                 425                 430         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Met Lys Thr Val 
        435                 440                 445             


Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
    450                 455                 460                 


Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp Gly Gln 
465                 470                 475                 480 


Gly Thr Gln Val Thr Val Ser Ser 
                485             


<210>  2194
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2194

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser 
    130                 135                 140                 


Gly Ser Ala Val Gln Gln Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
                165                 170                 175     


Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu 
            180                 185                 190         


Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
225                 230                 235                 240 


Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 


<210>  2195
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2195

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Ser Gly Ser Ala Val Gln Gln Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Lys Arg Glu Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Phe Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile 
                245                 250                 255     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 


<210>  2196
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2196

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Ser Ala Val Gln Gln 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Ser Trp 
            180                 185                 190         


Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Leu Val Ala Asp Ile Thr 
        195                 200                 205             


Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn Ala Val Thr Tyr 
                245                 250                 255     


Asn Gly Tyr Thr Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys 
            


<210>  2197
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2197

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ala Val Gln Gln Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Leu Asp Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Lys Arg Glu Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser 
        355                 360                 365             


Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
    370                 375                 380                 


Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg Ile Phe Ala 
385                 390                 395                 400 


Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly Asn Gln Arg Glu 
                405                 410                 415     


Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp Tyr Ala Asp 
            420                 425                 430         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Met Lys Thr 
        435                 440                 445             


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
    450                 455                 460                 


Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu Tyr Trp Gly 
465                 470                 475                 480 


Gln Gly Thr Gln Val Thr Val Ser Ser 
                485                 


<210>  2198
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2198

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly 
        35                  40                  45              


Arg Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly 
    50                  55                  60                  


Asn Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                85                  90                  95      


Ala Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr 
    130                 135                 140                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
145                 150                 155                 160 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                165                 170                 175     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            180                 185                 190         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        195                 200                 205             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    210                 215                 220                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
225                 230                 235                 240 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                245                 250                 255     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            260                 265                 270         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys 
        275                 280                 285             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    290                 295                 300                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
305                 310                 315                 320 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                325                 330                 335     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            340                 345                 350         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365             


Gly Gly Ser Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    370                 375                 380                 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Arg 
385                 390                 395                 400 


Ile Phe Ala Ile Tyr Asp Ile Ala Trp Tyr Arg His Pro Pro Gly Asn 
                405                 410                 415     


Gln Arg Glu Leu Val Ala Met Ile Arg Pro Val Val Thr Glu Ile Asp 
            420                 425                 430         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala 
        435                 440                 445             


Met Lys Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
    450                 455                 460                 


Ala Val Tyr Tyr Cys Asn Ala Lys Arg Pro Trp Gly Ser Arg Asp Glu 
465                 470                 475                 480 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                485                 490         


<210>  2199
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Nab-Nab-Fc construct

<400>  2199

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ala Val Gln Gln Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Leu Asp Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Lys Arg Glu Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Ile Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser 
        355                 360                 365             


Gly Ser Ala Val Gln Gln Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    370                 375                 380                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
385                 390                 395                 400 


Tyr Tyr Ala Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu 
                405                 410                 415     


Leu Val Ala Asp Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
            420                 425                 430         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile 
        435                 440                 445             


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
    450                 455                 460                 


Cys Asn Ala Val Thr Tyr Asn Gly Tyr Thr Ile Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly His His His His His 
                485                 490                 495     


His 
    


<210>  2200
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2200

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Asp Val Lys Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val 
    290                 295                 300                 


Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu 
305                 310                 315                 320 


Asn Gly Gly Ser Thr Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser 
            340                 345                 350         


Leu Lys Ser Glu Asp Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala 
        355                 360                 365             


Gly Tyr Gly Thr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ala Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser 
385                 390                 395                 400 


Gly Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr 
                405                 410                 415     


Pro Gly Asp Ser Val Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser 
            420                 425                 430         


Tyr Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu 
        435                 440                 445             


Leu Ile Lys Tyr Thr Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val 
465                 470                 475                 480 


Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp 
                485                 490                 495     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly 
            500                 505                 510         


Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        515                 520                 525             


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    530                 535                 540                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                565                 570                 575     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            580                 585                 590         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        595                 600                 605             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
    610                 615                 620                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
625                 630                 635                 640 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                645                 650                 655     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            660                 665                 670         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        675                 680                 685             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    690                 695                 700                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
705                 710                 715                 720 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                725                 730                 735     


Leu Ser Pro Gly Lys 
            740     


<210>  2201
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2201

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Ser 
    290                 295                 300                 


Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val 
305                 310                 315                 320 


Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr Tyr Tyr Ser Asp Thr Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
        355                 360                 365             


Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro Phe Ala Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ala Gly Ser Ala Ala Ser Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Ser Gly Ala Asp Ile Val Leu Thr Gln Ser Pro Ala 
                405                 410                 415     


Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys Lys Ala 
            420                 425                 430         


Ser Gln Ser Ile Ser Tyr Asn Leu His Trp Tyr Gln Gln Lys Ser His 
        435                 440                 445             


Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser Gln Ser Ile Ser Gly 
    450                 455                 460                 


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
465                 470                 475                 480 


Thr Ile Asn Asn Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln 
                485                 490                 495     


Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            500                 505                 510         


Val Lys Gly Ser Gly Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys 
        515                 520                 525             


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    530                 535                 540                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
545                 550                 555                 560 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                565                 570                 575     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            580                 585                 590         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        595                 600                 605             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    610                 615                 620                 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
625                 630                 635                 640 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                645                 650                 655     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            660                 665                 670         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        675                 680                 685             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    690                 695                 700                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
705                 710                 715                 720 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                725                 730                 735     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745     


<210>  2202
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2202

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Gly Ser Ser Gly Gly Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
305                 310                 315                 320 


Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr Tyr 
                325                 330                 335     


Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
        355                 360                 365             


Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro Phe 
    370                 375                 380                 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser Ala 
385                 390                 395                 400 


Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val Leu 
                405                 410                 415     


Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser 
            420                 425                 430         


Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp Tyr 
        435                 440                 445             


Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser 
    450                 455                 460                 


Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe Gly 
                485                 490                 495     


Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala 
            500                 505                 510         


Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  2203
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2203

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser 
    130                 135                 140                 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val 
                165                 170                 175     


Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr 
        195                 200                 205             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe 
225                 230                 235                 240 


Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Glu Val Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr Thr Leu Ser 
    290                 295                 300                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile 
305                 310                 315                 320 


Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                325                 330                 335     


Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            340                 345                 350         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn 
        355                 360                 365             


Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
                405                 410                 415     


Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe 
            420                 425                 430         


Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
        435                 440                 445             


Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
    450                 455                 460                 


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
465                 470                 475                 480 


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu 
                485                 490                 495     


Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Gly 
            500                 505                 510         


Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        515                 520                 525             


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    530                 535                 540                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                565                 570                 575     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            580                 585                 590         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        595                 600                 605             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
    610                 615                 620                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
625                 630                 635                 640 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                645                 650                 655     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            660                 665                 670         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        675                 680                 685             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    690                 695                 700                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
705                 710                 715                 720 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                725                 730                 735     


Leu Ser Pro Gly Lys 
            740     


<210>  2204
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2204

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser 
    130                 135                 140                 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val 
                165                 170                 175     


Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr 
        195                 200                 205             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe 
225                 230                 235                 240 


Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        275                 280                 285             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    290                 295                 300                 


His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
305                 310                 315                 320 


Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser 
                405                 410                 415     


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
            420                 425                 430         


Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile 
    450                 455                 460                 


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
465                 470                 475                 480 


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
                485                 490                 495     


Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr 
            500                 505                 510         


Val Leu Gly Ser Gly Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys 
        515                 520                 525             


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    530                 535                 540                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
545                 550                 555                 560 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                565                 570                 575     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            580                 585                 590         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        595                 600                 605             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    610                 615                 620                 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
625                 630                 635                 640 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                645                 650                 655     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            660                 665                 670         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        675                 680                 685             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    690                 695                 700                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
705                 710                 715                 720 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                725                 730                 735     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745     


<210>  2205
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2205

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser 
    130                 135                 140                 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val 
                165                 170                 175     


Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr 
        195                 200                 205             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe 
225                 230                 235                 240 


Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Gly Ser Gly 
            260                 265                 270         


Ser Gly Gly Ser Ser Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr 
                325                 330                 335     


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp 
            340                 345                 350         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe 
    370                 375                 380                 


Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu 
                405                 410                 415     


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
            420                 425                 430         


Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn 
    450                 455                 460                 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
465                 470                 475                 480 


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp 
                485                 490                 495     


Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  2206
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2206

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro 
305                 310                 315                 320 


Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg 
        355                 360                 365             


Pro Pro Ile Arg Leu His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro 
                405                 410                 415     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
            420                 425                 430         


Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
    450                 455                 460                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
465                 470                 475                 480 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
            500                 505                 510         


Glu Ile Lys Gly Ser Gly Ser Gly Asp Lys Thr His Thr Cys Pro Pro 
        515                 520                 525             


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    530                 535                 540                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
545                 550                 555                 560 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                565                 570                 575     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            580                 585                 590         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        595                 600                 605             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    610                 615                 620                 


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
625                 630                 635                 640 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                645                 650                 655     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            660                 665                 670         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        675                 680                 685             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    690                 695                 700                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
705                 710                 715                 720 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                725                 730                 735     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745         


<210>  2207
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2207

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
    290                 295                 300                 


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu His Pro Arg Gly Ser Val 
    370                 375                 380                 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser 
385                 390                 395                 400 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Gln 
                405                 410                 415     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            420                 425                 430         


Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
    450                 455                 460                 


Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Gly Ser Gly Asp Lys Thr 
        515                 520                 525             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
    530                 535                 540                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
545                 550                 555                 560 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                565                 570                 575     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            580                 585                 590         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        595                 600                 605             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    610                 615                 620                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
625                 630                 635                 640 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                645                 650                 655     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            660                 665                 670         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        675                 680                 685             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    690                 695                 700                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
705                 710                 715                 720 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                725                 730                 735     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750         


<210>  2208
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2208

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Gly Ser Ser Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
            340                 345                 350         


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu His 
    370                 375                 380                 


Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser 
                405                 410                 415     


Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            420                 425                 430         


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser 
        435                 440                 445             


Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    450                 455                 460                 


Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                485                 490                 495     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr 
            500                 505                 510         


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Gly 
        515                 520                 525             


Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    530                 535                 540                 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
545                 550                 555                 560 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                565                 570                 575     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            580                 585                 590         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        595                 600                 605             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    610                 615                 620                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
625                 630                 635                 640 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                645                 650                 655     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            660                 665                 670         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        675                 680                 685             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    690                 695                 700                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
705                 710                 715                 720 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                725                 730                 735     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            740                 745                 750         


Leu Ser Pro Gly Lys 
        755         


<210>  2209
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2209

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu 
        115                 120                 125             


His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            180                 185                 190         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
                245                 250                 255     


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            260                 265                 270         


Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    290                 295                 300                 


Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro 
                405                 410                 415     


Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly 
            420                 425                 430         


Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly 
    450                 455                 460                 


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 
465                 470                 475                 480 


Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
                485                 490                 495     


Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Thr Val Leu Gly Ser Gly Ser Gly Asp Lys Thr His Thr Cys Pro Pro 
        515                 520                 525             


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    530                 535                 540                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
545                 550                 555                 560 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                565                 570                 575     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            580                 585                 590         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        595                 600                 605             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    610                 615                 620                 


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
625                 630                 635                 640 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                645                 650                 655     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            660                 665                 670         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        675                 680                 685             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    690                 695                 700                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
705                 710                 715                 720 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                725                 730                 735     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745         


<210>  2210
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2210

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu 
        115                 120                 125             


His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            180                 185                 190         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
                245                 250                 255     


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            260                 265                 270         


Gly Ser Gly Gly Ser Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 


Ser Gly Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser 
                325                 330                 335     


Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser 
            340                 345                 350         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        355                 360                 365             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val 
    370                 375                 380                 


Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 
                405                 410                 415     


Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg 
            420                 425                 430         


Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser 
    450                 455                 460                 


Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
465                 470                 475                 480 


Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala 
                485                 490                 495     


Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Asp Lys Thr 
        515                 520                 525             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
    530                 535                 540                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
545                 550                 555                 560 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                565                 570                 575     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            580                 585                 590         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        595                 600                 605             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    610                 615                 620                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
625                 630                 635                 640 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                645                 650                 655     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            660                 665                 670         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        675                 680                 685             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    690                 695                 700                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
705                 710                 715                 720 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                725                 730                 735     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750         


<210>  2211
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2211

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu 
        115                 120                 125             


His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            180                 185                 190         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
                245                 250                 255     


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            260                 265                 270         


Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Ser Gly Gly Glu Val Gln 
        275                 280                 285             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr Thr Leu Ser 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile 
                325                 330                 335     


Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            340                 345                 350         


Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        355                 360                 365             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn 
    370                 375                 380                 


Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
            420                 425                 430         


Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe 
        435                 440                 445             


Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
    450                 455                 460                 


Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
465                 470                 475                 480 


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
                485                 490                 495     


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu 
            500                 505                 510         


Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Gly 
        515                 520                 525             


Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    530                 535                 540                 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
545                 550                 555                 560 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                565                 570                 575     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            580                 585                 590         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        595                 600                 605             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    610                 615                 620                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
625                 630                 635                 640 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                645                 650                 655     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            660                 665                 670         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        675                 680                 685             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    690                 695                 700                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
705                 710                 715                 720 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                725                 730                 735     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            740                 745                 750         


Leu Ser Pro Gly Lys 
        755         


<210>  2212
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2212

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser 
                485                 490                 495     


Gly Ser Gly Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            500                 505                 510         


Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 
        515                 520                 525             


Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    530                 535                 540                 


Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr Tyr Tyr Ser 
545                 550                 555                 560 


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                565                 570                 575     


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Phe 
            580                 585                 590         


Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro Phe Ala Tyr 
        595                 600                 605             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser Ala Ala Ser 
    610                 615                 620                 


Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val Leu Thr Gln 
625                 630                 635                 640 


Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser Leu Ser 
                645                 650                 655     


Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp Tyr Gln Gln 
            660                 665                 670         


Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser Gln Ser 
        675                 680                 685             


Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe Gly Met Tyr 
705                 710                 715                 720 


Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr 
                725                 730                 735     


Lys Leu Glu Val Lys 
            740     


<210>  2213
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2213

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser 
    130                 135                 140                 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val 
                165                 170                 175     


Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr 
        195                 200                 205             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe 
225                 230                 235                 240 


Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


Gly Ser Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            500                 505                 510         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        515                 520                 525             


Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys 
    530                 535                 540                 


Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr 
545                 550                 555                 560 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser 
                565                 570                 575     


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            580                 585                 590         


Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn 
        595                 600                 605             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln 
625                 630                 635                 640 


Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys 
                645                 650                 655     


Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln Lys 
            660                 665                 670         


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg Pro 
        675                 680                 685             


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
    690                 695                 700                 


Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
705                 710                 715                 720 


Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly Thr 
                725                 730                 735     


Lys Leu Thr Val Leu 
            740     


<210>  2214
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2214

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ala Val Val Leu Gln Glu Pro Ser Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser 
        35                  40                  45              


Gly Ser Val Ser Thr Asn Tyr Tyr Pro Ser Trp Tyr Gln Asp Thr Pro 
    50                  55                  60                  


Gly Gln Asp Pro Arg Thr Leu Ile Tyr Tyr Thr Asn Thr Arg Ser Ser 
65                  70                  75                  80  


Asp Val Pro Glu Arg Phe Ser Gly Ser Ile Val Gly Asn Lys Ala Ala 
                85                  90                  95      


Leu Thr Ile Thr Gly Ala Gln Pro Asp Asp Glu Ser Val Tyr Phe Cys 
            100                 105                 110         


Leu Leu Tyr Leu Gly Arg Gly Ile Trp Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
                165                 170                 175     


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
            180                 185                 190         


Gln Ser Asn Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro 
        195                 200                 205             


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 
    210                 215                 220                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235             


<210>  2215
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2215

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Ser Cys Ser Ala Asn 
        35                  40                  45              


Ser Ser Val Arg Phe Met Phe Trp Tyr Gln Lys Lys Pro Gly Ser Lys 
    50                  55                  60                  


Pro Lys Pro Leu Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


His Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  2216
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2216

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Thr Tyr Tyr Ile His Trp Leu Lys Asp Arg Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Trp Ile Phe Pro Gly Asn Val Asn Thr 
65                  70                  75                  80  


Lys Tyr Asn Ala Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Ala Arg Glu Glu Leu Gln Tyr Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Asp Gly Ser Thr Leu Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Lys Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Gly Ser Gly Ser Gly Glu Val Gln Leu Val Gln Ser Gly 
                245                 250                 255     


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
            260                 265                 270         


Ser Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Lys Ala 
        275                 280                 285             


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly 
    290                 295                 300                 


Asn Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr 
305                 310                 315                 320 


Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser 
                325                 330                 335     


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr 
            340                 345                 350         


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
465                 470                 475                 480 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                485                 490                 495     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            500                 505                 510         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        515                 520                 525             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    530                 535                 540                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
545                 550                 555                 560 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                565                 570                 575     


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            580                 585                 590         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        595                 600                 605             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    610                 615                 620                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
625                 630                 635                 640 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                645                 650                 655     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            660                 665                 670         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        675                 680                 685             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 700 


<210>  2217
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2217

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2218
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2218

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2219
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2219

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Glu Val 
                245                 250                 255     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
        275                 280                 285             


His Trp Val Arg Asp Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser 
    290                 295                 300                 


Ile Ser Ser Thr Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Ser Cys Ala Lys 
            340                 345                 350         


Thr Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr Phe Asp Tyr Trp Gly 
        355                 360                 365             


Asp Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    370                 375                 380                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
385                 390                 395                 400 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                405                 410                 415     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            420                 425                 430         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Lys Ser Val Val Thr Val 
        435                 440                 445             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    450                 455                 460                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
465                 470                 475                 480 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                485                 490                 495     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            500                 505                 510         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        515                 520                 525             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    530                 535                 540                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
545                 550                 555                 560 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                565                 570                 575     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            580                 585                 590         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        595                 600                 605             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    610                 615                 620                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
625                 630                 635                 640 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                645                 650                 655     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            660                 665                 670         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        675                 680                 685             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    690                 695                 700                 


Pro Gly Lys 
705         


<210>  2220
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2220

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2221
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2221

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2222
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2222

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Gly Ser 
                245                 250                 255     


Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        275                 280                 285             


Ser Ser Tyr Ala Met His Trp Val Arg Asp Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Glu Trp Val Ala Ser Ile Ser Ser Thr Ser Gly Ser Lys Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                325                 330                 335     


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Ser Cys Ala Lys Thr Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr 
        355                 360                 365             


Phe Asp Tyr Trp Gly Asp Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    370                 375                 380                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
385                 390                 395                 400 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                405                 410                 415     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            420                 425                 430         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Lys 
        435                 440                 445             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    450                 455                 460                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
465                 470                 475                 480 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                485                 490                 495     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            500                 505                 510         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        515                 520                 525             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    530                 535                 540                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
545                 550                 555                 560 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                565                 570                 575     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            580                 585                 590         


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        595                 600                 605             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    610                 615                 620                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
625                 630                 635                 640 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                645                 650                 655     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            660                 665                 670         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        675                 680                 685             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    690                 695                 700                 


Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710         


<210>  2223
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2223

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2224
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2224

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2225
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2225

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Gly Ser 
                245                 250                 255     


Gly Ser Gly Gly Ser Ser Gly Gly Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Asp Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Thr Ser Gly 
305                 310                 315                 320 


Ser Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Ser Cys Ala Lys Thr Tyr Tyr Asp Phe Trp 
        355                 360                 365             


Ser Gly Tyr Tyr Thr Phe Asp Tyr Trp Gly Asp Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
385                 390                 395                 400 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                405                 410                 415     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            420                 425                 430         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        435                 440                 445             


Leu Tyr Ser Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    450                 455                 460                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
465                 470                 475                 480 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                485                 490                 495     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            500                 505                 510         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        515                 520                 525             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    530                 535                 540                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
545                 550                 555                 560 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                565                 570                 575     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            580                 585                 590         


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        595                 600                 605             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    610                 615                 620                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
625                 630                 635                 640 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                645                 650                 655     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            660                 665                 670         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        675                 680                 685             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    690                 695                 700                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715         


<210>  2226
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2226

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2227
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2227

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Tyr Val Gly Asp Arg Val Thr Ile Thr Cys Arg Val Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Tyr Thr Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2228
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2228

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Glu Val 
                245                 250                 255     


Gln Leu Val Glu Ser Val Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
        275                 280                 285             


His Trp Val Arg Asp Ala Pro Gly Lys Gly Leu Glu Trp Ile Ser Thr 
    290                 295                 300                 


Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            340                 345                 350         


Ala Gly Tyr Gly Arg Tyr Tyr Tyr Gly Met Asp Val Trp Gly Asp Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    370                 375                 380                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
385                 390                 395                 400 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                405                 410                 415     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            420                 425                 430         


Gln Ser Ser Gly Leu Tyr Ser Leu Lys Ser Val Val Thr Val Pro Ser 
        435                 440                 445             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    450                 455                 460                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                485                 490                 495     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        515                 520                 525             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
            580                 585                 590         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        595                 600                 605             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    610                 615                 620                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            660                 665                 670         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700                 


Lys 
705 


<210>  2229
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2229

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2230
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2230

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Tyr Val Gly Asp Arg Val Thr Ile Thr Cys Arg Val Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Tyr Thr Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2231
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2231

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Gly Ser 
                245                 250                 255     


Gly Ser Gly Glu Val Gln Leu Val Glu Ser Val Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        275                 280                 285             


Ser Ser Tyr Ala Met His Trp Val Arg Asp Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Glu Trp Ile Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                325                 330                 335     


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Ala Gly Tyr Gly Arg Tyr Tyr Tyr Gly Met Asp 
        355                 360                 365             


Val Trp Gly Asp Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    370                 375                 380                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
385                 390                 395                 400 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                405                 410                 415     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            420                 425                 430         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Lys Ser Val 
        435                 440                 445             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    450                 455                 460                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
465                 470                 475                 480 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                485                 490                 495     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            500                 505                 510         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        515                 520                 525             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    530                 535                 540                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
545                 550                 555                 560 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                565                 570                 575     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
            580                 585                 590         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        595                 600                 605             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    610                 615                 620                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
625                 630                 635                 640 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                645                 650                 655     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            660                 665                 670         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        675                 680                 685             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    690                 695                 700                 


Ser Leu Ser Pro Gly Lys 
705                 710 


<210>  2232
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2232

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2233
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2233

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Tyr Val Gly Asp Arg Val Thr Ile Thr Cys Arg Val Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Tyr Thr Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2234
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2234

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Gly Ser 
                245                 250                 255     


Gly Ser Gly Gly Ser Ser Gly Gly Glu Val Gln Leu Val Glu Ser Val 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Asp Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Ile Ser Thr Ile Ser Gly Ser Gly Gly 
305                 310                 315                 320 


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Tyr Gly Arg Tyr 
        355                 360                 365             


Tyr Tyr Gly Met Asp Val Trp Gly Asp Gly Thr Thr Val Thr Val Ser 
    370                 375                 380                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
385                 390                 395                 400 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                405                 410                 415     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            420                 425                 430         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        435                 440                 445             


Ser Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    450                 455                 460                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
465                 470                 475                 480 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
            500                 505                 510         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        515                 520                 525             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    530                 535                 540                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
545                 550                 555                 560 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                565                 570                 575     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            580                 585                 590         


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        595                 600                 605             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    610                 615                 620                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
625                 630                 635                 640 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                645                 650                 655     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            660                 665                 670         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        675                 680                 685             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    690                 695                 700                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715 


<210>  2235
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2235

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Tyr Val Gly Asp Arg Val Thr Ile Thr Cys Arg Val Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Tyr Thr Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2236
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2236

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2237
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2237

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Val Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Asp Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Tyr Gly Arg Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Asp Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Gln Val Gln Leu Gln 
                245                 250                 255     


Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr 
            260                 265                 270         


Cys Ala Val Ser Gly Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile 
        275                 280                 285             


Arg Lys Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His 
    290                 295                 300                 


Thr Gly Ser Thr Asn Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile 
305                 310                 315                 320 


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val 
                325                 330                 335     


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly 
            340                 345                 350         


Gly Tyr Asp Trp Gly His Tyr His Gly Leu Asp Val Trp Gly Lys Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    370                 375                 380                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
385                 390                 395                 400 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                405                 410                 415     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            420                 425                 430         


Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser Val Val Thr Val Pro Ser 
        435                 440                 445             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    450                 455                 460                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
                485                 490                 495     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        515                 520                 525             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
            580                 585                 590         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        595                 600                 605             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    610                 615                 620                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            660                 665                 670         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700                 


Lys 
705 


<210>  2238
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2238

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Tyr Val Gly Asp Arg Val Thr Ile Thr Cys Arg Val Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Tyr Thr Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2239
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2239

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2240
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2240

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Val Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Asp Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Tyr Gly Arg Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Asp Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
                245                 250                 255     


Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
            260                 265                 270         


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Phe Ser Gly His 
        275                 280                 285             


Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly Lys Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Glu Pro Ser Leu Arg 
305                 310                 315                 320 


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
                325                 330                 335     


Asn Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly His Tyr His Gly Leu Asp 
        355                 360                 365             


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    370                 375                 380                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
385                 390                 395                 400 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                405                 410                 415     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            420                 425                 430         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser Val 
        435                 440                 445             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    450                 455                 460                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
465                 470                 475                 480 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                485                 490                 495     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            500                 505                 510         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        515                 520                 525             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    530                 535                 540                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
545                 550                 555                 560 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                565                 570                 575     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
            580                 585                 590         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        595                 600                 605             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    610                 615                 620                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
625                 630                 635                 640 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                645                 650                 655     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            660                 665                 670         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        675                 680                 685             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    690                 695                 700                 


Ser Leu Ser Pro Gly Lys 
705                 710 


<210>  2241
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2241

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Tyr Val Gly Asp Arg Val Thr Ile Thr Cys Arg Val Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys 
    50                  55                  60                  


Lys Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Thr Tyr Thr Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2242
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2242

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Asp Lys Pro Gly Gln Asp 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Lys Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  2243
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2243

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Val Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Asp Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Tyr Gly Arg Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Asp Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
                245                 250                 255     


Gly Ser Ser Gly Gly Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            260                 265                 270         


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala 
        275                 280                 285             


Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Lys Pro Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr 
305                 310                 315                 320 


Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                325                 330                 335     


Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly His 
        355                 360                 365             


Tyr His Gly Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
    370                 375                 380                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
385                 390                 395                 400 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                405                 410                 415     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            420                 425                 430         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        435                 440                 445             


Ser Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    450                 455                 460                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
465                 470                 475                 480 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
            500                 505                 510         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        515                 520                 525             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    530                 535                 540                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
545                 550                 555                 560 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                565                 570                 575     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            580                 585                 590         


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        595                 600                 605             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    610                 615                 620                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
625                 630                 635                 640 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                645                 650                 655     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            660                 665                 670         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        675                 680                 685             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    690                 695                 700                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715 


<210>  2244
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2244

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Gln Trp Gly Ala Gly 
            20                  25                  30          


Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly 
        35                  40                  45              


Ala Ser Phe Ser Gly His Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Asp His Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Glu Pro Ser Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Asn Leu Lys Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Gln Gly Gly Tyr Asp Trp Gly 
        115                 120                 125             


His Tyr His Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly His His 
                245                 250                 255     


His His His His 
            260 


<210>  2245
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2245

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  2246
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2246

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
        35                  40                  45              


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
            100                 105                 110         


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Gly Ser Gly Ser Gly 
225                 230                 235                 240 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                245                 250                 255     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            260                 265                 270         


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        275                 280                 285             


Ala Ser Ile Ser Ser Thr Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    290                 295                 300                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Ser Cys 
                325                 330                 335     


Ala Lys Thr Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr Phe Asp Tyr 
            340                 345                 350         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        355                 360                 365             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    370                 375                 380                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
385                 390                 395                 400 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                405                 410                 415     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            420                 425                 430         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        435                 440                 445             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    450                 455                 460                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
465                 470                 475                 480 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                485                 490                 495     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            500                 505                 510         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        515                 520                 525             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    530                 535                 540                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
545                 550                 555                 560 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
                565                 570                 575     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            580                 585                 590         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        595                 600                 605             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    610                 615                 620                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
625                 630                 635                 640 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                645                 650                 655     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            660                 665                 670         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        675                 680                 685             


Leu Ser Pro Gly Lys 
    690             


<210>  2247
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2247

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Gly Ser Gly Ser Gly His His His His His His 
                245                 250                 255     


<210>  2248
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2248

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ala Ala Ala Asp Ile Val Leu Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys 
        35                  40                  45              


Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe Gly Met Tyr Phe 
            100                 105                 110         


Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
                245                 250                 255     


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
            260                 265                 270         


Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly 
        275                 280                 285             


Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr 
    290                 295                 300                 


Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
305                 310                 315                 320 


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr Tyr Gly 
            340                 345                 350         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        355                 360                 365             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    370                 375                 380                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
385                 390                 395                 400 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                405                 410                 415     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            420                 425                 430         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        435                 440                 445             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    450                 455                 460                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
465                 470                 475                 480 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                485                 490                 495     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            500                 505                 510         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        515                 520                 525             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    530                 535                 540                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
545                 550                 555                 560 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                565                 570                 575     


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            580                 585                 590         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        595                 600                 605             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    610                 615                 620                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
625                 630                 635                 640 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                645                 650                 655     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            660                 665                 670         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        675                 680                 685             


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly His His His 
    690                 695                 700                 


His His His 
705         


<210>  2249
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAde in Lab - Fab-IgG construct

<400>  2249

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ala Ala Ala Asp Ile Val Leu Thr Gln Ser 
            20                  25                  30          


Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys 
        35                  40                  45              


Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe Gly Met Tyr Phe 
            100                 105                 110         


Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser 
                245                 250                 255     


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
            260                 265                 270         


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn 
    290                 295                 300                 


Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr 
305                 310                 315                 320 


Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg 
                325                 330                 335     


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala 
            340                 345                 350         


Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        355                 360                 365             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
465                 470                 475                 480 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                485                 490                 495     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        515                 520                 525             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
545                 550                 555                 560 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    610                 615                 620                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                645                 650                 655     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly 
    690                 695                 700                 


Ser Gly His His His His His His 
705                 710         


<210>  2250
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - Tandem scFv-Fc construct

<400>  2250

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser 
                485                 490                 495     


Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            500                 505                 510         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        515                 520                 525             


Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    530                 535                 540                 


Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala 
545                 550                 555                 560 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                565                 570                 575     


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            580                 585                 590         


Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu His Pro Arg 
        595                 600                 605             


Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    610                 615                 620                 


Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala 
625                 630                 635                 640 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                645                 650                 655     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            660                 665                 670         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        675                 680                 685             


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                725                 730                 735     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            740                 745         


<210>  2251
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - R2M3-26F(ab')2 Fd construct

<400>  2251

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly 
            260             


<210>  2252
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 10SG11-1RC07 LC  construct

<400>  2252

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Ser Gly Ser Gly Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
    130                 135                 140                 


Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys 
145                 150                 155                 160 


Val Gly His Lys Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
                165                 170                 175     


Pro Val Leu Val Ile Tyr Glu Asp Ser Gln Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Val Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
        195                 200                 205             


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp 
    210                 215                 220                 


Asp Ser Ser Thr Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
                245                 250                 255     


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
            260                 265                 270         


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
        275                 280                 285             


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
    290                 295                 300                 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
305                 310                 315                 320 


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
                325                 330                 335     


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            340                 345         


<210>  2253
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 10SG11-1RC07 HC  construct

<400>  2253

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Tyr Arg Tyr Leu His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Arg Ile Ile Pro Val Leu Lys Ile Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Val Val Asp Asp Ala Phe Asp Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Gly Ser Gly Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Phe Ser Gly His Tyr 
                165                 170                 175     


Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Glu Pro Ser Leu Arg Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Asn 
    210                 215                 220                 


Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Gly Gln Gly Gly Tyr Asp Trp Gly His Tyr His Gly Leu Asp Val 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
            260                 265                 270         


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
        275                 280                 285             


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
    290                 295                 300                 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
305                 310                 315                 320 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
                325                 330                 335     


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
            340                 345                 350         


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
        355                 360                 365             


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    370                 375                 380                 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
385                 390                 395                 400 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                405                 410                 415     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            420                 425                 430         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        435                 440                 445             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    450                 455                 460                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
465                 470                 475                 480 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                485                 490                 495     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            500                 505                 510         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        515                 520                 525             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    530                 535                 540                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
545                 550                 555                 560 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                565                 570                 575     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            580                 585                 590         


Leu Ser Pro Gly Lys 
        595         


<210>  2254
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - R2M3-26 CL, and R2M3-26 NL Heavy chain construct

<400>  2254

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ser Ser Lys Glu Lys Ala Thr Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  2255
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - 18R5:5:1115.3:His construct

<400>  2255

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Asp Val Lys Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val 
    290                 295                 300                 


Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu 
305                 310                 315                 320 


Asn Gly Gly Ser Thr Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser 
            340                 345                 350         


Leu Lys Ser Glu Asp Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala 
        355                 360                 365             


Gly Tyr Gly Thr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ala Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser 
385                 390                 395                 400 


Gly Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr 
                405                 410                 415     


Pro Gly Asp Ser Val Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser 
            420                 425                 430         


Tyr Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu 
        435                 440                 445             


Leu Ile Lys Tyr Thr Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val 
465                 470                 475                 480 


Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp 
                485                 490                 495     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly 
            500                 505                 510         


Ser Gly His His His His His His 
        515                 520 


<210>  2256
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 18R5:10:1115.3:His construct

<400>  2256

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Ser 
    290                 295                 300                 


Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val 
305                 310                 315                 320 


Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr Tyr Tyr Ser Asp Thr Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
            340                 345                 350         


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
        355                 360                 365             


Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro Phe Ala Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ala Gly Ser Ala Ala Ser Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Ser Gly Ala Asp Ile Val Leu Thr Gln Ser Pro Ala 
                405                 410                 415     


Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser Leu Ser Cys Lys Ala 
            420                 425                 430         


Ser Gln Ser Ile Ser Tyr Asn Leu His Trp Tyr Gln Gln Lys Ser His 
        435                 440                 445             


Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser Gln Ser Ile Ser Gly 
    450                 455                 460                 


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
465                 470                 475                 480 


Thr Ile Asn Asn Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln 
                485                 490                 495     


Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
            500                 505                 510         


Val Lys Gly Ser Gly Ser Gly His His His His His His 
        515                 520                 525 


<210>  2257
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - 18R5:15:1115.3:His construct

<400>  2257

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Gly Ser Ser Gly Gly Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
305                 310                 315                 320 


Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr Tyr 
                325                 330                 335     


Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
        355                 360                 365             


Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro Phe 
    370                 375                 380                 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser Ala 
385                 390                 395                 400 


Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val Leu 
                405                 410                 415     


Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser 
            420                 425                 430         


Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp Tyr 
        435                 440                 445             


Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser 
    450                 455                 460                 


Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe Gly 
                485                 490                 495     


Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly Ala 
            500                 505                 510         


Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly His His His His 
        515                 520                 525             


His His 
    530 


<210>  2258
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 1115.3:5:18R5:His construct

<400>  2258

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser 
    130                 135                 140                 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val 
                165                 170                 175     


Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr 
        195                 200                 205             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe 
225                 230                 235                 240 


Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Glu Val Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr Thr Leu Ser 
    290                 295                 300                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile 
305                 310                 315                 320 


Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                325                 330                 335     


Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            340                 345                 350         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn 
        355                 360                 365             


Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
                405                 410                 415     


Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe 
            420                 425                 430         


Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
        435                 440                 445             


Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
    450                 455                 460                 


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
465                 470                 475                 480 


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu 
                485                 490                 495     


Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Gly 
            500                 505                 510         


Ser Gly His His His His His His 
        515                 520 


<210>  2259
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 1115.3:10:18R5:His construct

<400>  2259

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser 
    130                 135                 140                 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val 
                165                 170                 175     


Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr 
        195                 200                 205             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe 
225                 230                 235                 240 


Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        275                 280                 285             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
    290                 295                 300                 


His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
305                 310                 315                 320 


Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser 
                405                 410                 415     


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
            420                 425                 430         


Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile 
    450                 455                 460                 


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
465                 470                 475                 480 


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
                485                 490                 495     


Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr 
            500                 505                 510         


Val Leu Gly Ser Gly Ser Gly His His His His His His 
        515                 520                 525 


<210>  2260
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 1115.3:15:18R5:His construct

<400>  2260

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Leu Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Ser Phe Ser Thr Ser Tyr Met Ser Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Leu Asn Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Phe Tyr Tyr Cys Ala Ser Glu Leu Ala Gly Tyr Gly Thr Pro 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser 
    130                 135                 140                 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val 
                165                 170                 175     


Ser Leu Ser Cys Lys Ala Ser Gln Ser Ile Ser Tyr Asn Leu His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr 
        195                 200                 205             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Glu Thr Glu Asp Phe 
225                 230                 235                 240 


Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Val Lys Gly Ser Gly Ser Gly Gly Ser Gly 
            260                 265                 270         


Ser Gly Gly Ser Ser Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
        275                 280                 285             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    290                 295                 300                 


Gly Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr 
                325                 330                 335     


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp 
            340                 345                 350         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        355                 360                 365             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe 
    370                 375                 380                 


Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu 
                405                 410                 415     


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
            420                 425                 430         


Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn 
    450                 455                 460                 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
465                 470                 475                 480 


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp 
                485                 490                 495     


Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly His His His His 
        515                 520                 525             


His His 
    530 


<210>  2261
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 18R5:5:YW211.31.57:His construct

<400>  2261

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro 
305                 310                 315                 320 


Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg 
        355                 360                 365             


Pro Pro Ile Arg Leu His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro 
                405                 410                 415     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
            420                 425                 430         


Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        435                 440                 445             


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
    450                 455                 460                 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
465                 470                 475                 480 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
            500                 505                 510         


Glu Ile Lys Gly Ser Gly Ser Gly His His His His His His 
        515                 520                 525     


<210>  2262
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 18R5:10:YW211.31.57:His construct

<400>  2262

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
    290                 295                 300                 


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
305                 310                 315                 320 


Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu His Pro Arg Gly Ser Val 
    370                 375                 380                 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser 
385                 390                 395                 400 


Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser Gly Ala Asp Ile Gln 
                405                 410                 415     


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            420                 425                 430         


Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
    450                 455                 460                 


Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Gly Ser Gly His His His 
        515                 520                 525             


His His His 
    530     


<210>  2263
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - 18R5:15:YW211.31.57:His construct

<400>  2263

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala 
        115                 120                 125             


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
            260                 265                 270         


Gly Ser Ser Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    290                 295                 300                 


Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr Tyr 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
            340                 345                 350         


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu His 
    370                 375                 380                 


Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser Ser 
                405                 410                 415     


Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            420                 425                 430         


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser 
        435                 440                 445             


Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    450                 455                 460                 


Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                485                 490                 495     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr 
            500                 505                 510         


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Gly 
        515                 520                 525             


Ser Gly His His His His His His 
    530                 535     


<210>  2264
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - YW211.31.57:5:18R5:His construct

<400>  2264

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu 
        115                 120                 125             


His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            180                 185                 190         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
                245                 250                 255     


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            260                 265                 270         


Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        275                 280                 285             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    290                 295                 300                 


Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro 
                405                 410                 415     


Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly 
            420                 425                 430         


Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly 
    450                 455                 460                 


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 
465                 470                 475                 480 


Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
                485                 490                 495     


Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Thr Val Leu Gly Ser Gly Ser Gly His His His His His His 
        515                 520                 525     


<210>  2265
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - YW211.31.57:10:18R5:His construct

<400>  2265

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu 
        115                 120                 125             


His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            180                 185                 190         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
                245                 250                 255     


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            260                 265                 270         


Gly Ser Gly Gly Ser Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    290                 295                 300                 


Ser Gly Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser 
                325                 330                 335     


Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser 
            340                 345                 350         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        355                 360                 365             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val 
    370                 375                 380                 


Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 
                405                 410                 415     


Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg 
            420                 425                 430         


Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Ser 
    450                 455                 460                 


Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
465                 470                 475                 480 


Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala 
                485                 490                 495     


Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu Val Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Gly Ser Gly His His His 
        515                 520                 525             


His His His 
    530     


<210>  2266
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - YW211.31.57:15:18R5:His construct

<400>  2266

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu 
        115                 120                 125             


His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            180                 185                 190         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
                245                 250                 255     


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            260                 265                 270         


Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Ser Gly Gly Glu Val Gln 
        275                 280                 285             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr Thr Leu Ser 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile 
                325                 330                 335     


Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            340                 345                 350         


Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        355                 360                 365             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn 
    370                 375                 380                 


Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
            420                 425                 430         


Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe 
        435                 440                 445             


Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
    450                 455                 460                 


Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
465                 470                 475                 480 


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
                485                 490                 495     


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu 
            500                 505                 510         


Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Gly 
        515                 520                 525             


Ser Gly His His His His His His 
    530                 535     


<210>  2267
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - YW211.31.57:Fc:18R5 construct

<400>  2267

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Glu Ile Ser Pro Tyr Ser Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Leu Arg Ala Arg Pro Pro Ile Arg Leu 
        115                 120                 125             


His Pro Arg Gly Ser Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Ser Ala Ala Ser Gly Ser Ser Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            180                 185                 190         


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr 
                245                 250                 255     


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser 
            260                 265                 270         


Gly Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly Glu Val Gln Leu Val 
            500                 505                 510         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        515                 520                 525             


Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr Thr Leu Ser Trp Val 
    530                 535                 540                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Gly 
545                 550                 555                 560 


Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                565                 570                 575     


Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
            580                 585                 590         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Phe Ile 
        595                 600                 605             


Lys Tyr Val Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
                645                 650                 655     


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
            660                 665                 670         


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        675                 680                 685             


Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    690                 695                 700                 


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
705                 710                 715                 720 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
                725                 730                 735     


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            740                 745         


