                         SEQUENCE LISTING

<110>  Cell Design Labs, Inc.
 
<120>  Single- and Multi-Chain Chimeric Antigen Receptors

<130>  43159-0069WO1

<150>  US 62/609,895
<151>  2017-12-22

<150>  US 62/767,212
<151>  2018-11-14

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        35                  40                  


<210>  2
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  2
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gt                                                          132


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
            20                  25                  30  


<210>  4
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  4
cagacaacac caggcgagag atctagcctg cccgccttct accctggcac cagcggctct       60

tgttctggct gtggcagcct gtctctgccc                                        90


<210>  5
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  6
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  25  


<210>  7
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  8
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  9
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  10
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  11
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  12
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210>  13
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  13

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  15
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  15
atctatattt gggcacccct ggctggaacc tgcggagtgc tgctgctgtc tctcgtgatt       60

acactgtatt gc                                                           72


<210>  16
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  16
gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt       60

atcacccttt actgc                                                        75


<210>  17
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence FMC63 VL

<400>  17
gacatccaga tgacccagac caccagcagc ctgagcgcca gcctgggcga tagagtgacc       60

atcagctgca gagccagcca ggacatcagc aagtacctga actggtatca gcagaaaccc      120

gacggcaccg tgaagctgct gatctaccac accagcagac tgcacagcgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaacag      240

gaagatatcg ctacctactt ctgtcagcaa ggcaacaccc tgccctacac cttcggcgga      300

ggcaccaagc tggaaatcac a                                                321


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence FMC63 VL

<400>  18

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  19
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence (G4S)3 linker

<400>  19
ggcggcggag gatctggcgg aggcggaagt ggcggagggg gatct                       45


<210>  20
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence FMC63 VH

<400>  20
gaagtgaaac tgcaggaaag cggccctggc ctggtggccc catctcagtc tctgagcgtg       60

acctgtaccg tgtccggcgt gtccctgcct gactatggcg tgtcctggat cagacagccc      120

cccagaaagg gcctggaatg gctgggagtg atctggggca gcgagacaac ctactacaac      180

agcgccctga agtcccggct gaccatcatc aaggacaact ccaagagcca ggtgttcctg      240

aagatgaaca gcctgcagac cgacgacacc gccatctact actgcgccaa gcactactac      300

tacggcggca gctacgccat ggactactgg ggccagggca caagcgtgac cgtgtctagc      360


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence FMC63 VH

<400>  21

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  22

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  23

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  24

Arg Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  25
ggatccggca gcggatctgg cagtggaagc                                        30


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  26
ggatctggct ctggaagcgg cagc                                              24


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  27
agatccggat ctggaagtgg ctcc                                              24


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  28
ggaagtggat ctgggagcgg ctct                                              24


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  29
ggatcaggca gtggctctgg cagc                                              24


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  30
ggatctggaa gtggctcc                                                     18


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide sequence

<400>  31

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  32
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  33
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Cys Val Cys Ser Ser Asn Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Ser 
            20                  25                  30          


Lys Ile Ser Leu Pro Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Leu Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Asp Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Lys Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Pro Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Asn Val Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Gln Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr His Leu Met Met Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Asp Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  34
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  35
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Leu Trp Ile Trp Ala Val Leu Pro Leu Val Leu Ala Gly Ser Gln 
1               5                   10                  15      


Leu Arg Val His Thr Gln Gly Thr Asn Ser Ile Ser Glu Ser Leu Lys 
            20                  25                  30          


Leu Arg Arg Arg Val Arg Glu Thr Asp Lys Asn Cys Ser Glu Gly Leu 
        35                  40                  45              


Tyr Gln Gly Gly Pro Phe Cys Cys Gln Pro Cys Gln Pro Gly Lys Lys 
    50                  55                  60                  


Lys Val Glu Asp Cys Lys Met Asn Gly Gly Thr Pro Thr Cys Ala Pro 
65                  70                  75                  80  


Cys Thr Glu Gly Lys Glu Tyr Met Asp Lys Asn His Tyr Ala Asp Lys 
                85                  90                  95      


Cys Arg Arg Cys Thr Leu Cys Asp Glu Glu His Gly Leu Glu Val Glu 
            100                 105                 110         


Thr Asn Cys Thr Leu Thr Gln Asn Thr Lys Cys Lys Cys Lys Pro Asp 
        115                 120                 125             


Phe Tyr Cys Asp Ser Pro Gly Cys Glu His Cys Val Arg Cys Ala Ser 
    130                 135                 140                 


Cys Glu His Gly Thr Leu Glu Pro Cys Thr Ala Thr Ser Asn Thr Asn 
145                 150                 155                 160 


Cys Arg Lys Gln Ser Pro Arg Asn Arg Leu Trp Leu Leu Thr Ile Leu 
                165                 170                 175     


Val Leu Leu Ile Pro Leu Val Phe Ile Tyr Arg Lys Tyr Arg Lys Arg 
            180                 185                 190         


Lys Cys Trp Lys Arg Arg Gln Asp Asp Pro Glu Ser Arg Thr Ser Ser 
        195                 200                 205             


Arg Glu Thr Ile Pro Met Asn Ala Ser Asn Leu Ser Leu Ser Lys Tyr 
    210                 215                 220                 


Ile Pro Arg Ile Ala Glu Asp Met Thr Ile Gln Glu Ala Lys Lys Phe 
225                 230                 235                 240 


Ala Arg Glu Asn Asn Ile Lys Glu Gly Lys Ile Asp Glu Ile Met His 
                245                 250                 255     


Asp Ser Ile Gln Asp Thr Ala Glu Gln Lys Val Gln Leu Leu Leu Cys 
            260                 265                 270         


Trp Tyr Gln Ser His Gly Lys Ser Asp Ala Tyr Gln Asp Leu Ile Lys 
        275                 280                 285             


Gly Leu Lys Lys Ala Glu Cys Arg Arg Thr Leu Asp Lys Phe Gln Asp 
    290                 295                 300                 


Met Val Gln Lys Asp Leu Gly Lys Ser Thr Pro Asp Thr Gly Asn Glu 
305                 310                 315                 320 


Asn Glu Gly Gln Cys Leu Glu 
                325         


<210>  36
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  37
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Leu Pro Thr Val Pro Gly Leu Leu Leu Ser Leu Val Leu Leu 
1               5                   10                  15      


Ala Leu Leu Met Gly Ile His Pro Ser Gly Val Thr Gly Leu Val Pro 
            20                  25                  30          


Ser Leu Gly Asp Arg Glu Lys Arg Asp Ser Leu Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Val His Ser Lys Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Val Ser Asp Cys Pro Ser Pro Gly Arg Asp Thr Val 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Lys Gly Thr Phe Thr Ala Ser Gln Asn Tyr Leu 
                85                  90                  95      


Arg Gln Cys Leu Ser Cys Lys Thr Cys Arg Lys Glu Met Ser Gln Val 
            100                 105                 110         


Glu Ile Ser Pro Cys Gln Ala Asp Lys Asp Thr Val Cys Gly Cys Lys 
        115                 120                 125             


Glu Asn Gln Phe Gln Arg Tyr Leu Ser Glu Thr His Phe Gln Cys Val 
    130                 135                 140                 


Asp Cys Ser Pro Cys Phe Asn Gly Thr Val Thr Ile Pro Cys Lys Glu 
145                 150                 155                 160 


Thr Gln Asn Thr Val Cys Asn Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Ser Glu Cys Val Pro Cys Ser His Cys Lys Lys Asn Glu Glu Cys Met 
            180                 185                 190         


Lys Leu Cys Leu Pro Pro Pro Leu Ala Asn Val Thr Asn Pro Gln Asp 
        195                 200                 205             


Ser Gly Thr Ala Val Leu Leu Pro Leu Val Ile Leu Leu Gly Leu Cys 
    210                 215                 220                 


Leu Leu Ser Phe Ile Phe Ile Ser Leu Met Cys Arg Tyr Pro Arg Trp 
225                 230                 235                 240 


Arg Pro Glu Val Tyr Ser Ile Ile Cys Arg Asp Pro Val Pro Val Lys 
                245                 250                 255     


Glu Glu Lys Ala Gly Lys Pro Leu Thr Pro Ala Pro Ser Pro Ala Phe 
            260                 265                 270         


Ser Pro Thr Ser Gly Phe Asn Pro Thr Leu Gly Phe Ser Thr Pro Gly 
        275                 280                 285             


Phe Ser Ser Pro Val Ser Ser Thr Pro Ile Ser Pro Ile Phe Gly Pro 
    290                 295                 300                 


Ser Asn Trp His Phe Met Pro Pro Val Ser Glu Val Val Pro Thr Gln 
305                 310                 315                 320 


Gly Ala Asp Pro Leu Leu Tyr Glu Ser Leu Cys Ser Val Pro Ala Pro 
                325                 330                 335     


Thr Ser Val Gln Lys Trp Glu Asp Ser Ala His Pro Gln Arg Pro Asp 
            340                 345                 350         


Asn Ala Asp Leu Ala Ile Leu Tyr Ala Val Val Asp Gly Val Pro Pro 
        355                 360                 365             


Ala Arg Trp Lys Glu Phe Met Arg Phe Met Gly Leu Ser Glu His Glu 
    370                 375                 380                 


Ile Glu Arg Leu Glu Met Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Glu Ala Trp Arg Arg Arg Thr Pro Arg His Glu Asp 
                405                 410                 415     


Thr Leu Glu Val Val Gly Leu Val Leu Ser Lys Met Asn Leu Ala Gly 
            420                 425                 430         


Cys Leu Glu Asn Ile Leu Glu Ala Leu Arg Asn Pro Ala Pro Ser Ser 
        435                 440                 445             


Thr Thr Arg Leu Pro Arg 
    450                 


<210>  38
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  39
<211>  474
<212>  PRT
<213>  Mus musculus

<400>  39

Met Ala Pro Ala Ala Leu Trp Val Ala Leu Val Phe Glu Leu Gln Leu 
1               5                   10                  15      


Trp Ala Thr Gly His Thr Val Pro Ala Gln Val Val Leu Thr Pro Tyr 
            20                  25                  30          


Lys Pro Glu Pro Gly Tyr Glu Cys Gln Ile Ser Gln Glu Tyr Tyr Asp 
        35                  40                  45              


Arg Lys Ala Gln Met Cys Cys Ala Lys Cys Pro Pro Gly Gln Tyr Val 
    50                  55                  60                  


Lys His Phe Cys Asn Lys Thr Ser Asp Thr Val Cys Ala Asp Cys Glu 
65                  70                  75                  80  


Ala Ser Met Tyr Thr Gln Val Trp Asn Gln Phe Arg Thr Cys Leu Ser 
                85                  90                  95      


Cys Ser Ser Ser Cys Thr Thr Asp Gln Val Glu Ile Arg Ala Cys Thr 
            100                 105                 110         


Lys Gln Gln Asn Arg Val Cys Ala Cys Glu Ala Gly Arg Tyr Cys Ala 
        115                 120                 125             


Leu Lys Thr His Ser Gly Ser Cys Arg Gln Cys Met Arg Leu Ser Lys 
    130                 135                 140                 


Cys Gly Pro Gly Phe Gly Val Ala Ser Ser Arg Ala Pro Asn Gly Asn 
145                 150                 155                 160 


Val Leu Cys Lys Ala Cys Ala Pro Gly Thr Phe Ser Asp Thr Thr Ser 
                165                 170                 175     


Ser Thr Asp Val Cys Arg Pro His Arg Ile Cys Ser Ile Leu Ala Ile 
            180                 185                 190         


Pro Gly Asn Ala Ser Thr Asp Ala Val Cys Ala Pro Glu Ser Pro Thr 
        195                 200                 205             


Leu Ser Ala Ile Pro Arg Thr Leu Tyr Val Ser Gln Pro Glu Pro Thr 
    210                 215                 220                 


Arg Ser Gln Pro Leu Asp Gln Glu Pro Gly Pro Ser Gln Thr Pro Ser 
225                 230                 235                 240 


Ile Leu Thr Ser Leu Gly Ser Thr Pro Ile Ile Glu Gln Ser Thr Lys 
                245                 250                 255     


Gly Gly Ile Ser Leu Pro Ile Gly Leu Ile Val Gly Val Thr Ser Leu 
            260                 265                 270         


Gly Leu Leu Met Leu Gly Leu Val Asn Cys Ile Ile Leu Val Gln Arg 
        275                 280                 285             


Lys Lys Lys Pro Ser Cys Leu Gln Arg Asp Ala Lys Val Pro His Val 
    290                 295                 300                 


Pro Asp Glu Lys Ser Gln Asp Ala Val Gly Leu Glu Gln Gln His Leu 
305                 310                 315                 320 


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
                325                 330                 335     


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
            340                 345                 350         


Val Met Ala Glu Ala Gln Gly Phe Gln Glu Ala Arg Ala Ser Ser Arg 
        355                 360                 365             


Ile Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
    370                 375                 380                 


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
385                 390                 395                 400 


Ser Gln Ala Ser Ala Thr Val Gly Asp Pro Asp Ala Lys Pro Ser Ala 
                405                 410                 415     


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
            420                 425                 430         


Gln Ser Pro Cys Glu Thr Thr Glu Thr Leu Gln Ser His Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Met Gly Met Lys Pro Ser Gln Ala Gly 
    450                 455                 460                 


Trp Phe Asp Gln Ile Ala Val Lys Val Ala 
465                 470                 


<210>  40
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  41
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  41

Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      


Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          


Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              


Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  


Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ile Gln Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu 
                85                  90                  95      


Thr Gly Ala Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp 
            100                 105                 110         


Glu Thr Arg Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp 
        115                 120                 125             


Gly Ala Leu Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys 
    130                 135                 140                 


Val Gln Leu Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu 
145                 150                 155                 160 


Pro Ile Thr His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser 
            180                 185                 190         


Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu 
        195                 200                 205             


Glu Ala Gly Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val 
    210                 215                 220                 


Arg Pro Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 


<210>  42
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  43
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  43

Met Lys Pro Tyr Phe Cys Arg Val Phe Val Phe Cys Phe Leu Ile Arg 
1               5                   10                  15      


Leu Leu Thr Gly Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Leu Cys Leu Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asn Asn Pro Asp Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
    130                 135                 140                 


Pro Val Gly Cys Ala Ala Phe Val Val Val Leu Leu Phe Gly Cys Ile 
145                 150                 155                 160 


Leu Ile Ile Trp Phe Ser Lys Lys Lys Tyr Gly Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys 
            180                 185                 190         


Ser Arg Leu Ala Gly Val Thr Ser 
        195                 200 


<210>  44
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  45
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  45

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  46
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  46
aaaaggggcc ggaaaaagct gctgtatatt ttcaaacagc cttttatgag gcctgtgcag       60

acaacacagg aagaggacgg ctgtagctgt cggttccccg aagaggaaga ggggggctgc      120

gaactg                                                                 126


<210>  47
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  47

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40      


<210>  48
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  48
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaa                                                                    123


<210>  49
<211>  256
<212>  PRT
<213>  Mus musculus

<400>  49

Met Gly Asn Asn Cys Tyr Asn Val Val Val Ile Val Leu Leu Leu Val 
1               5                   10                  15      


Gly Cys Glu Lys Val Gly Ala Val Gln Asn Ser Cys Asp Asn Cys Gln 
            20                  25                  30          


Pro Gly Thr Phe Cys Arg Lys Tyr Asn Pro Val Cys Lys Ser Cys Pro 
        35                  40                  45              


Pro Ser Thr Phe Ser Ser Ile Gly Gly Gln Pro Asn Cys Asn Ile Cys 
    50                  55                  60                  


Arg Val Cys Ala Gly Tyr Phe Arg Phe Lys Lys Phe Cys Ser Ser Thr 
65                  70                  75                  80  


His Asn Ala Glu Cys Glu Cys Ile Glu Gly Phe His Cys Leu Gly Pro 
                85                  90                  95      


Gln Cys Thr Arg Cys Glu Lys Asp Cys Arg Pro Gly Gln Glu Leu Thr 
            100                 105                 110         


Lys Gln Gly Cys Lys Thr Cys Ser Leu Gly Thr Phe Asn Asp Gln Asn 
        115                 120                 125             


Gly Thr Gly Val Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Arg 
    130                 135                 140                 


Ser Val Leu Lys Thr Gly Thr Thr Glu Lys Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Pro Val Val Ser Phe Ser Pro Ser Thr Thr Ile Ser Val Thr Pro Glu 
                165                 170                 175     


Gly Gly Pro Gly Gly His Ser Leu Gln Val Leu Thr Leu Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Leu Leu Leu Ala Leu Ile Phe Ile Thr Leu Leu Phe 
        195                 200                 205             


Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
225                 230                 235                 240 


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
                245                 250                 255     


<210>  50
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  51
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  52
<211>  250
<212>  PRT
<213>  Mus musculus

<400>  52

Met Ala Trp Pro Pro Pro Tyr Trp Leu Cys Met Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Leu Ala Pro Asn Ser Cys Pro Asp Lys His Tyr 
            20                  25                  30          


Trp Thr Gly Gly Gly Leu Cys Cys Arg Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Phe Val Lys Asp Cys Glu Gln Asp Arg Thr Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Thr Ser Phe Ser Pro Asp Tyr His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Phe Leu Ile Arg Asn Cys 
                85                  90                  95      


Thr Val Thr Ala Asn Ala Glu Cys Ser Cys Ser Lys Asn Trp Gln Cys 
            100                 105                 110         


Arg Asp Gln Glu Cys Thr Glu Cys Asp Pro Pro Leu Asn Pro Ala Leu 
        115                 120                 125             


Thr Arg Gln Pro Ser Glu Thr Pro Ser Pro Gln Pro Pro Pro Thr His 
    130                 135                 140                 


Leu Pro His Gly Thr Glu Lys Pro Ser Trp Pro Leu His Arg Gln Leu 
145                 150                 155                 160 


Pro Asn Ser Thr Val Tyr Ser Gln Arg Ser Ser His Arg Pro Leu Cys 
                165                 170                 175     


Ser Ser Asp Cys Ile Arg Ile Phe Val Thr Phe Ser Ser Met Phe Leu 
            180                 185                 190         


Ile Phe Val Leu Gly Ala Ile Leu Phe Phe His Gln Arg Arg Asn His 
        195                 200                 205             


Gly Pro Asn Glu Asp Arg Gln Ala Val Pro Glu Glu Pro Cys Pro Tyr 
    210                 215                 220                 


Ser Cys Pro Arg Glu Glu Glu Gly Ser Ala Ile Pro Ile Gln Glu Asp 
225                 230                 235                 240 


Tyr Arg Lys Pro Glu Pro Ala Phe Tyr Pro 
                245                 250 


<210>  53
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  54
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  55
<211>  272
<212>  PRT
<213>  Mus musculus

<400>  55

Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Phe Ala Val Leu Leu Gly Leu Gly Leu Gly Leu Leu 
    210                 215                 220                 


Ala Pro Leu Thr Val Leu Leu Ala Leu Tyr Leu Leu Arg Lys Ala Trp 
225                 230                 235                 240 


Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn Ser Phe Arg Thr 
                245                 250                 255     


Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


<210>  56
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  57
<211>  344
<212>  PRT
<213>  Mus musculus

<400>  57

Met Lys Cys Lys Phe Leu Gly Ser Phe Phe Leu Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gly Lys Gly Ala Asp Cys Arg Asp Asn Glu Thr Ile Trp Gly Val Leu 
            20                  25                  30          


Gly His Gly Ile Thr Leu Asn Ile Pro Asn Phe Gln Met Thr Asp Asp 
        35                  40                  45              


Ile Asp Glu Val Arg Trp Val Arg Arg Gly Thr Leu Val Ala Glu Phe 
    50                  55                  60                  


Lys Arg Lys Lys Pro Pro Phe Leu Ile Ser Glu Thr Tyr Glu Val Leu 
65                  70                  75                  80  


Ala Asn Gly Ser Leu Lys Ile Lys Lys Pro Met Met Arg Asn Asp Ser 
                85                  90                  95      


Gly Thr Tyr Asn Val Met Val Tyr Gly Thr Asn Gly Met Thr Arg Leu 
            100                 105                 110         


Glu Lys Asp Leu Asp Val Arg Ile Leu Glu Arg Val Ser Lys Pro Met 
        115                 120                 125             


Ile His Trp Glu Cys Pro Asn Thr Thr Leu Thr Cys Ala Val Leu Gln 
    130                 135                 140                 


Gly Thr Asp Phe Glu Leu Lys Leu Tyr Gln Gly Glu Thr Leu Leu Asn 
145                 150                 155                 160 


Ser Leu Pro Gln Lys Asn Met Ser Tyr Gln Trp Thr Asn Leu Asn Ala 
                165                 170                 175     


Pro Phe Lys Cys Glu Ala Ile Asn Pro Val Ser Lys Glu Ser Lys Met 
            180                 185                 190         


Glu Val Val Asn Cys Pro Glu Lys Gly Leu Ser Phe Tyr Val Thr Val 
        195                 200                 205             


Gly Val Gly Ala Gly Gly Leu Leu Leu Val Leu Leu Val Ala Leu Phe 
    210                 215                 220                 


Ile Phe Cys Ile Cys Lys Arg Arg Lys Arg Asn Arg Arg Arg Lys Asp 
225                 230                 235                 240 


Glu Glu Leu Glu Ile Lys Ala Ser Arg Thr Ser Thr Val Glu Arg Gly 
                245                 250                 255     


Pro Lys Pro His Ser Thr Pro Ala Ala Ala Ala Gln Asn Ser Val Ala 
            260                 265                 270         


Leu Gln Ala Pro Pro Pro Pro Gly His His Leu Gln Thr Pro Gly His 
        275                 280                 285             


Arg Pro Leu Pro Pro Gly His Arg Thr Arg Glu His Gln Gln Lys Lys 
    290                 295                 300                 


Arg Pro Pro Pro Ser Gly Thr Gln Ile His Gln Gln Lys Gly Pro Pro 
305                 310                 315                 320 


Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro Cys Gly Ser Gly Asp 
                325                 330                 335     


Gly Val Ser Leu Pro Pro Pro Asn 
            340                 


<210>  58
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg 
    130                 135                 140                 


Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys 
            180                 185                 190         


Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro 
    210                 215                 220                 


Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln 
225                 230                 235                 240 


Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro 
                245                 250                 255     


Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr 
        275                 280                 285             


Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr 
                325                 330                 335     


Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu 
            340                 345                 350         


Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln 
        355                 360                 365             


Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile 
    370                 375                 380                 


Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu 
385                 390                 395                 400 


Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln 
                405                 410                 415     


Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn 
            420                 425                 430         


His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His 
        435                 440                 445             


Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala 
    450                 455                 460                 


Tyr Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp 
465                 470                 475                 480 


Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                485                 490                 495 


<210>  59
<211>  494
<212>  PRT
<213>  Mus musculus

<400>  59

Met Asp Ser His Glu Val Leu Leu Ala Ala Thr Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Leu Ala Ala Phe Cys Leu Gly Gln Ser Gly Arg Gly Gly Leu Asp Ile 
            20                  25                  30          


Gln Val Met Leu Ser Gly Ser Asn Ser Lys Cys Gln Gly Gln Val Glu 
        35                  40                  45              


Ile Gln Met Glu Asn Lys Trp Lys Thr Val Cys Ser Ser Ser Trp Arg 
    50                  55                  60                  


Leu Ser Gln Asp His Ser Lys Asn Ala Gln Gln Ala Ser Ala Val Cys 
65                  70                  75                  80  


Lys Gln Leu Arg Cys Gly Asp Pro Leu Ala Leu Gly Pro Phe Pro Ser 
                85                  90                  95      


Leu Asn Arg Pro Gln Asn Gln Val Phe Cys Gln Gly Ser Pro Trp Ser 
            100                 105                 110         


Ile Ser Asn Cys Asn Asn Thr Ser Ser Gln Asp Gln Cys Leu Pro Leu 
        115                 120                 125             


Ser Leu Ile Cys Leu Glu Pro Gln Arg Thr Thr Pro Pro Pro Thr Thr 
    130                 135                 140                 


Thr Pro Pro Thr Thr Val Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Pro Gly His Glu Gly Leu Arg Cys Thr Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Asn Gly Ser Trp Gly Gly Thr Ile Leu Tyr Lys Ala Lys Asp Arg 
            180                 185                 190         


Pro Leu Gly Leu Gly Asn Leu Ile Cys Lys Ser Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Thr His Leu Ser Gly Thr Glu Ala Ala Gly Thr Pro Ala Pro 
    210                 215                 220                 


Ala Glu Leu Arg Asp Pro Arg Pro Leu Pro Ile Arg Trp Glu Ala Pro 
225                 230                 235                 240 


Asn Gly Ser Cys Val Ser Leu Gln Gln Cys Phe Gln Lys Thr Thr Ala 
                245                 250                 255     


Gln Glu Gly Gly Gln Ala Leu Thr Val Ile Cys Ser Asp Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Val Cys Glu Gly Ile 
        275                 280                 285             


Ala Glu Val Arg Gln Arg Ser Gln Trp Glu Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ala Ala Arg Gly Arg Gly Arg Trp Glu Glu Leu Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Asp Leu Ile Ser Phe His Thr Val Asp Ala Asp Lys Thr Ser 
                325                 330                 335     


Pro Gly Phe Leu Cys Ala Gln Glu Lys Leu Ser Gln Cys Tyr His Leu 
            340                 345                 350         


Gln Lys Lys Lys His Cys Asn Lys Arg Val Phe Val Thr Cys Gln Asp 
        355                 360                 365             


Pro Asn Pro Ala Gly Leu Ala Pro Gly Thr Val Ala Ser Ile Ile Leu 
    370                 375                 380                 


Thr Leu Val Leu Leu Val Val Leu Leu Ala Met Cys Gly Pro Leu Val 
385                 390                 395                 400 


Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln Trp 
                405                 410                 415     


Ile Gly Pro Thr Gly Val Asn Gln Asn Met Ser Phe His Arg Ser His 
            420                 425                 430         


Thr Ala Thr Val Arg Ser Gln Val Glu Asn Pro Thr Ala Ser His Val 
        435                 440                 445             


Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala Tyr 
    450                 455                 460                 


Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Thr Gln Pro Asp Asn 
465                 470                 475                 480 


Ser Ser Asp Ser Asp Tyr Asp Leu Gln Val Ala Gln Arg Leu 
                485                 490                 


<210>  60
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  61
<211>  498
<212>  PRT
<213>  Mus musculus

<400>  61

Met Ser Ala Leu Leu Thr Ala Ala Gly Leu Leu Phe Leu Gly Met Leu 
1               5                   10                  15      


Gln Ala Phe Pro Thr Asp Arg Pro Leu Lys Thr Thr Cys Ala Gly Asp 
            20                  25                  30          


Leu Ser His Tyr Pro Gly Glu Ala Ala Arg Asn Cys Cys Tyr Gln Cys 
        35                  40                  45              


Pro Ser Gly Leu Ser Pro Thr Gln Pro Cys Pro Arg Gly Pro Ala His 
    50                  55                  60                  


Cys Arg Lys Gln Cys Ala Pro Asp Tyr Tyr Val Asn Glu Asp Gly Lys 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Leu Pro Gly Leu Val Glu Lys Ala Pro 
                85                  90                  95      


Cys Ser Gly Asn Ser Pro Arg Ile Cys Glu Cys Gln Pro Gly Met His 
            100                 105                 110         


Cys Cys Thr Pro Ala Val Asn Ser Cys Ala Arg Cys Lys Leu His Cys 
        115                 120                 125             


Ser Gly Glu Glu Val Val Lys Ser Pro Gly Thr Ala Lys Lys Asp Thr 
    130                 135                 140                 


Ile Cys Glu Leu Pro Ser Ser Gly Ser Gly Pro Asn Cys Ser Asn Pro 
145                 150                 155                 160 


Gly Asp Arg Lys Thr Leu Thr Ser His Ala Thr Pro Gln Ala Met Pro 
                165                 170                 175     


Thr Leu Glu Ser Pro Ala Asn Asp Ser Ala Arg Ser Leu Leu Pro Met 
            180                 185                 190         


Arg Val Thr Asn Leu Val Gln Glu Asp Ala Thr Glu Leu Val Lys Val 
        195                 200                 205             


Pro Glu Ser Ser Ser Ser Lys Ala Arg Glu Pro Ser Pro Asp Pro Gly 
    210                 215                 220                 


Asn Ala Glu Lys Asn Met Thr Leu Glu Leu Pro Ser Pro Gly Thr Leu 
225                 230                 235                 240 


Pro Asp Ile Ser Thr Ser Glu Asn Ser Lys Glu Pro Ala Ser Thr Ala 
                245                 250                 255     


Ser Thr Leu Ser Leu Val Val Asp Ala Trp Thr Ser Ser Arg Met Gln 
            260                 265                 270         


Pro Thr Ser Pro Leu Ser Thr Gly Thr Pro Phe Leu Asp Pro Gly Pro 
        275                 280                 285             


Val Leu Phe Trp Val Ala Met Val Val Leu Leu Val Gly Ser Gly Ser 
    290                 295                 300                 


Phe Leu Leu Cys Tyr Trp Lys Ala Cys Arg Arg Arg Phe Gln Gln Lys 
305                 310                 315                 320 


Phe His Leu Asp Tyr Leu Val Gln Thr Phe Gln Pro Lys Met Glu Gln 
                325                 330                 335     


Thr Asp Ser Cys Pro Thr Glu Lys Leu Thr Gln Pro Gln Arg Ser Gly 
            340                 345                 350         


Ser Val Thr Asp Pro Ser Thr Gly His Lys Leu Ser Pro Val Ser Pro 
        355                 360                 365             


Pro Pro Ala Val Glu Thr Cys Ala Ser Val Gly Ala Thr Tyr Leu Glu 
    370                 375                 380                 


Asn Leu Pro Leu Leu Asp Asp Ser Pro Ala Gly Asn Pro Phe Ser Pro 
385                 390                 395                 400 


Arg Glu Pro Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Arg 
                405                 410                 415     


Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Ser 
            420                 425                 430         


Val Lys Thr Glu Val Pro Glu Gly Arg Ala Pro Ala Gly Ser Thr Glu 
        435                 440                 445             


Ser Glu Leu Glu Ala Glu Leu Glu Val Asp His Ala Pro His Tyr Pro 
    450                 455                 460                 


Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Thr Glu Val Met Phe 
465                 470                 475                 480 


Ser Val Glu Glu Gly Gly Lys Glu Asp His Gly Pro Thr Thr Val Ser 
                485                 490                 495     


Glu Lys 
        


<210>  62
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  63
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  63

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Ala Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60              


<210>  64
<211>  289
<212>  PRT
<213>  Mus musculus

<400>  64

Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu Gly Gln Cys Val Thr Cys Ser Asp Lys Gln Tyr Leu 
            20                  25                  30          


His Asp Gly Gln Cys Cys Asp Leu Cys Gln Pro Gly Ser Arg Leu Thr 
        35                  40                  45              


Ser His Cys Thr Ala Leu Glu Lys Thr Gln Cys His Pro Cys Asp Ser 
    50                  55                  60                  


Gly Glu Phe Ser Ala Gln Trp Asn Arg Glu Ile Arg Cys His Gln His 
65                  70                  75                  80  


Arg His Cys Glu Pro Asn Gln Gly Leu Arg Val Lys Lys Glu Gly Thr 
                85                  90                  95      


Ala Glu Ser Asp Thr Val Cys Thr Cys Lys Glu Gly Gln His Cys Thr 
            100                 105                 110         


Ser Lys Asp Cys Glu Ala Cys Ala Gln His Thr Pro Cys Ile Pro Gly 
        115                 120                 125             


Phe Gly Val Met Glu Met Ala Thr Glu Thr Thr Asp Thr Val Cys His 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Gln Ser Ser Leu Phe Glu Lys 
145                 150                 155                 160 


Cys Tyr Pro Trp Thr Ser Cys Glu Asp Lys Asn Leu Glu Val Leu Gln 
                165                 170                 175     


Lys Gly Thr Ser Gln Thr Asn Val Ile Cys Gly Leu Lys Ser Arg Met 
            180                 185                 190         


Arg Ala Leu Leu Val Ile Pro Val Val Met Gly Ile Leu Ile Thr Ile 
        195                 200                 205             


Phe Gly Val Phe Leu Tyr Ile Lys Lys Val Val Lys Lys Pro Lys Asp 
    210                 215                 220                 


Asn Glu Ile Leu Pro Pro Ala Ala Arg Arg Gln Asp Pro Gln Glu Met 
225                 230                 235                 240 


Glu Asp Tyr Pro Gly His Asn Thr Ala Ala Pro Val Gln Glu Thr Leu 
                245                 250                 255     


His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile 
            260                 265                 270         


Ser Val Gln Glu Arg Gln Val Thr Asp Ser Ile Ala Leu Arg Pro Leu 
        275                 280                 285             


Val 
    


<210>  65
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  65

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  66
<211>  218
<212>  PRT
<213>  Mus musculus

<400>  66

Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210>  67
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp 
            100                 105                 110         


Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu 
        115                 120                 125             


Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg 
    130                 135                 140                 


Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu 
145                 150                 155                 160 


Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu 
                165                 170                 175     


Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln 
            180                 185                 190         


Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe 
        195                 200                 205             


Ser Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val 
    210                 215                 220                 


Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val 
225                 230                 235                 240 


Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr 
                245                 250                 255     


Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn 
            260                 265                 270         


Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys 
        275                 280                 285             


His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser 
    290                 295                 300                 


Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu 
305                 310                 315                 320 


Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly 
                325                 330                 335     


Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser 
            340                 345                 350         


Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val 
        355                 360                 365             


Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu 
    370                 375                 380                 


Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg 
385                 390                 395                 400 


Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys 
                405                 410                 415     


Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg 
            420                 425                 430         


Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val 
        435                 440                 445             


Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu 
    450                 455                 460                 


Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile 
465                 470                 475                 480 


Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile 
                485                 490                 495     


Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly 
            500                 505                 510         


Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu 
        515                 520                 525             


Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro 
    530                 535                 540                 


Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly 
545                 550                 555                 560 


Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser 
                565                 570                 575     


Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu 
            580                 585                 590         


Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile 
        595                 600                 605             


Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe 
    610                 615                 620                 


Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr 
625                 630                 635                 640 


Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile 
                645                 650                 655     


Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr 
            660                 665                 670         


Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe 
        675                 680                 685             


Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser 
    690                 695                 700                 


Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp 
705                 710                 715                 720 


Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu 
                725                 730                 735     


Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro 
            740                 745                 750         


Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser 
    770                 775                 780                 


Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser 
785                 790                 795                 800 


Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp 
                805                 810                 815     


Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val 
            820                 825                 830         


Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu 
        835                 840                 845             


Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser 
    850                 855                 860                 


Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe 
865                 870                 875                 880 


Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala 
                885                 890                 895     


Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser 
            900                 905                 910         


Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln 
        915                 920                 925             


Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro 
    930                 935                 940                 


Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser 
945                 950                 955                 960 


Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro 
                965                 970                 975     


Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met 
            980                 985                 990         


Glu Pro Pro Val Pro Cys His Tyr  Glu Asp Leu Glu Arg  Leu Pro Asp 
        995                 1000                 1005             


Ala Ala  Glu Pro Cys Leu Pro  Gly Ala Leu Phe Arg  Cys Pro Val 
    1010                 1015                 1020             


Val Phe  Arg Gln Glu Ile Leu  Val Gln Val Ile Gly  Thr Leu Glu 
    1025                 1030                 1035             


Leu Val  Gly Glu Ile Glu Ala  Ser Ser Met Phe Ser  Leu Cys Ser 
    1040                 1045                 1050             


Ser Leu  Ser Ile Ser Phe Asn  Ser Ser Lys His Phe  His Leu Tyr 
    1055                 1060                 1065             


Gly Ser  Asn Ala Ser Leu Ala  Gln Val Val Met Lys  Val Asp Val 
    1070                 1075                 1080             


Val Tyr  Glu Lys Gln Met Leu  Tyr Leu Tyr Val Leu  Ser Gly Ile 
    1085                 1090                 1095             


Gly Gly  Leu Leu Leu Leu Leu  Leu Ile Phe Ile Val  Leu Tyr Lys 
    1100                 1105                 1110             


Val Gly  Phe Phe Lys Arg Asn  Leu Lys Glu Lys Met  Glu Ala Gly 
    1115                 1120                 1125             


Arg Gly  Val Pro Asn Gly Ile  Pro Ala Glu Asp Ser  Glu Gln Leu 
    1130                 1135                 1140             


Ala Ser  Gly Gln Glu Ala Gly  Asp Pro Gly Cys Leu  Lys Pro Leu 
    1145                 1150                 1155             


His Glu  Lys Asp Ser Glu Ser  Gly Gly Gly Lys Asp  
    1160                 1165                 1170 


<210>  68
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  68

Tyr Lys Val Gly Phe Phe Lys Arg Asn Leu Lys Glu Lys Met Glu Ala 
1               5                   10                  15      


Gly Arg Gly Val Pro Asn Gly Ile Pro Ala Glu Asp Ser Glu Gln Leu 
            20                  25                  30          


Ala Ser Gly Gln Glu Ala Gly Asp Pro Gly Cys Leu Lys Pro Leu His 
        35                  40                  45              


Glu Lys Asp Ser Glu Ser Gly Gly Gly Lys Asp 
    50                  55                  


<210>  69
<211>  1162
<212>  PRT
<213>  Mus musculus

<400>  69

Met Ser Phe Arg Ile Ala Gly Pro Arg Leu Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Leu Phe Ala Lys Ala Trp Ser Tyr Asn Leu Asp Thr Arg Pro Thr Gln 
            20                  25                  30          


Ser Phe Leu Ala Gln Ala Gly Arg His Phe Gly Tyr Gln Val Leu Gln 
        35                  40                  45              


Ile Glu Asp Gly Val Val Val Gly Ala Pro Gly Glu Gly Asp Asn Thr 
    50                  55                  60                  


Gly Gly Leu Tyr His Cys Arg Thr Ser Ser Glu Phe Cys Gln Pro Val 
65                  70                  75                  80  


Ser Leu His Gly Ser Asn His Thr Ser Lys Tyr Leu Gly Met Thr Leu 
                85                  90                  95      


Ala Thr Asp Ala Ala Lys Gly Ser Leu Leu Ala Cys Asp Pro Gly Leu 
            100                 105                 110         


Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu Cys Tyr Leu 
        115                 120                 125             


Phe Pro Gln Ser Leu Glu Gly Pro Met Leu Gln Asn Arg Pro Ala Tyr 
    130                 135                 140                 


Gln Glu Cys Met Lys Gly Lys Val Asp Leu Val Phe Leu Phe Asp Gly 
145                 150                 155                 160 


Ser Gln Ser Leu Asp Arg Lys Asp Phe Glu Lys Ile Leu Glu Phe Met 
                165                 170                 175     


Lys Asp Val Met Arg Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala 
            180                 185                 190         


Val Gln Phe Ser Thr Asp Cys Arg Thr Glu Phe Thr Phe Leu Asp Tyr 
        195                 200                 205             


Val Lys Gln Asn Lys Asn Pro Asp Val Leu Leu Gly Ser Val Gln Pro 
    210                 215                 220                 


Met Phe Leu Leu Thr Asn Thr Phe Arg Ala Ile Asn Tyr Val Val Ala 
225                 230                 235                 240 


His Val Phe Lys Glu Glu Ser Gly Ala Arg Pro Asp Ala Thr Lys Val 
                245                 250                 255     


Leu Val Ile Ile Thr Asp Gly Glu Ala Ser Asp Lys Gly Asn Ile Ser 
            260                 265                 270         


Ala Ala His Asp Ile Thr Arg Tyr Ile Ile Gly Ile Gly Lys His Phe 
        275                 280                 285             


Val Ser Val Gln Lys Gln Lys Thr Leu His Ile Phe Ala Ser Glu Pro 
    290                 295                 300                 


Val Glu Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp 
305                 310                 315                 320 


Leu Phe Thr Asp Leu Gln Arg Arg Ile Tyr Ala Ile Glu Gly Thr Asn 
                325                 330                 335     


Arg Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile 
            340                 345                 350         


Ser Ala Asp Leu Ser Lys Gly His Ala Val Val Gly Ala Val Gly Ala 
        355                 360                 365             


Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Arg Glu Asp Leu Gln Gly 
    370                 375                 380                 


Ala Thr Phe Val Gly Gln Glu Pro Leu Thr Ser Asp Val Arg Gly Gly 
385                 390                 395                 400 


Tyr Leu Gly Tyr Thr Val Ala Trp Met Thr Ser Arg Ser Ser Arg Pro 
                405                 410                 415     


Leu Leu Ala Ala Gly Ala Pro Arg Tyr Gln His Val Gly Gln Val Leu 
            420                 425                 430         


Leu Phe Gln Ala Pro Glu Ala Gly Gly Arg Trp Asn Gln Thr Gln Lys 
        435                 440                 445             


Ile Glu Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Ser 
    450                 455                 460                 


Val Asp Leu Asp Gln Asp Gly Glu Ala Glu Leu Leu Leu Ile Gly Ala 
465                 470                 475                 480 


Pro Leu Phe Phe Gly Glu Gln Arg Gly Gly Arg Val Phe Thr Tyr Gln 
                485                 490                 495     


Arg Arg Gln Ser Leu Phe Glu Met Val Ser Glu Leu Gln Gly Asp Pro 
            500                 505                 510         


Gly Tyr Pro Leu Gly Arg Phe Gly Ala Ala Ile Thr Ala Leu Thr Asp 
        515                 520                 525             


Ile Asn Gly Asp Arg Leu Thr Asp Val Ala Val Gly Ala Pro Leu Glu 
    530                 535                 540                 


Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Lys Pro Gly Gly Leu Ser 
545                 550                 555                 560 


Pro Gln Pro Ser Gln Arg Ile Gln Gly Ala Gln Val Phe Pro Gly Ile 
                565                 570                 575     


Arg Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Gly Gly Asp 
            580                 585                 590         


Arg Leu Ala Asp Val Val Val Gly Ala Glu Gly Arg Val Val Val Leu 
        595                 600                 605             


Ser Ser Arg Pro Val Val Asp Val Val Thr Glu Leu Ser Phe Ser Pro 
    610                 615                 620                 


Glu Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Ala Arg Glu 
625                 630                 635                 640 


Glu Gln Lys His Gly Val Lys Leu Lys Ala Cys Phe Arg Ile Lys Pro 
                645                 650                 655     


Leu Thr Pro Gln Phe Gln Gly Arg Leu Leu Ala Asn Leu Ser Tyr Thr 
            660                 665                 670         


Leu Gln Leu Asp Gly His Arg Met Arg Ser Arg Gly Leu Phe Pro Asp 
        675                 680                 685             


Gly Ser His Glu Leu Ser Gly Asn Thr Ser Ile Thr Pro Asp Lys Ser 
    690                 695                 700                 


Cys Leu Asp Phe His Phe His Phe Pro Ile Cys Ile Gln Asp Leu Ile 
705                 710                 715                 720 


Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Leu Glu Glu Glu Gly 
                725                 730                 735     


Thr Pro Arg Asp Gln Lys Val Gly Arg Ala Met Gln Pro Ile Leu Arg 
            740                 745                 750         


Pro Ser Ile His Thr Val Thr Lys Glu Ile Pro Phe Glu Lys Asn Cys 
        755                 760                 765             


Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Thr Leu Ser Ser Pro Ala 
    770                 775                 780                 


Arg Ser Gly Pro Leu Arg Leu Met Ser Ser Ala Ser Leu Ala Val Glu 
785                 790                 795                 800 


Trp Thr Leu Ser Asn Ser Gly Glu Asp Ala Tyr Trp Val Arg Leu Asp 
                805                 810                 815     


Leu Asp Phe Pro Arg Gly Leu Ser Phe Arg Lys Val Glu Met Leu Gln 
            820                 825                 830         


Pro His Ser Arg Met Pro Val Ser Cys Glu Glu Leu Thr Glu Gly Ser 
        835                 840                 845             


Ser Leu Leu Thr Lys Thr Leu Lys Cys Asn Val Ser Ser Pro Ile Phe 
    850                 855                 860                 


Lys Ala Gly Gln Glu Val Ser Leu Gln Val Met Phe Asn Thr Leu Leu 
865                 870                 875                 880 


Asn Ser Ser Trp Glu Asp Phe Val Glu Leu Asn Gly Thr Val His Cys 
                885                 890                 895     


Glu Asn Glu Asn Ser Ser Leu Gln Glu Asp Asn Ser Ala Ala Thr His 
            900                 905                 910         


Ile Pro Val Leu Tyr Pro Val Asn Ile Leu Thr Lys Glu Gln Glu Asn 
        915                 920                 925             


Ser Thr Leu Tyr Ile Ser Phe Thr Pro Lys Gly Pro Lys Thr Gln Gln 
    930                 935                 940                 


Val Gln His Val Tyr Gln Val Arg Ile Gln Pro Ser Ala Tyr Asp His 
945                 950                 955                 960 


Asn Met Pro Thr Leu Glu Ala Leu Val Gly Val Pro Trp Pro His Ser 
                965                 970                 975     


Glu Asp Pro Ile Thr Tyr Thr Trp Ser Val Gln Thr Asp Pro Leu Val 
            980                 985                 990         


Thr Cys His Ser Glu Asp Leu Lys  Arg Pro Ser Ser Glu  Ala Glu Gln 
        995                 1000                 1005             


Pro Cys  Leu Pro Gly Val Gln  Phe Arg Cys Pro Ile  Val Phe Arg 
    1010                 1015                 1020             


Arg Glu  Ile Leu Ile Gln Val  Thr Gly Thr Val Glu  Leu Ser Lys 
    1025                 1030                 1035             


Glu Ile  Lys Ala Ser Ser Thr  Leu Ser Leu Cys Ser  Ser Leu Ser 
    1040                 1045                 1050             


Val Ser  Phe Asn Ser Ser Lys  His Phe His Leu Tyr  Gly Ser Lys 
    1055                 1060                 1065             


Ala Ser  Glu Ala Gln Val Leu  Val Lys Val Asp Leu  Ile His Glu 
    1070                 1075                 1080             


Lys Glu  Met Leu His Val Tyr  Val Leu Ser Gly Ile  Gly Gly Leu 
    1085                 1090                 1095             


Val Leu  Leu Phe Leu Ile Phe  Leu Ala Leu Tyr Lys  Val Gly Phe 
    1100                 1105                 1110             


Phe Lys  Arg Asn Leu Lys Glu  Lys Met Glu Ala Asp  Gly Gly Val 
    1115                 1120                 1125             


Pro Asn  Gly Ser Pro Pro Glu  Asp Thr Asp Pro Leu  Ala Val Pro 
    1130                 1135                 1140             


Gly Glu  Glu Thr Lys Asp Met  Gly Cys Leu Glu Pro  Leu Arg Glu 
    1145                 1150                 1155             


Ser Asp  Lys Asp 
    1160         


<210>  70
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  71
<211>  537
<212>  PRT
<213>  Mus musculus

<400>  71

Met Ala Ser Thr Arg Ala Lys Pro Thr Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Thr Val Val Ile Pro Gly Pro Gly Asp Ala Gln Val Ser Ile His 
            20                  25                  30          


Pro Arg Glu Ala Phe Leu Pro Gln Gly Gly Ser Val Gln Val Asn Cys 
        35                  40                  45              


Ser Ser Ser Cys Lys Glu Asp Leu Ser Leu Gly Leu Glu Thr Gln Trp 
    50                  55                  60                  


Leu Lys Asp Glu Leu Glu Ser Gly Pro Asn Trp Lys Leu Phe Glu Leu 
65                  70                  75                  80  


Ser Glu Ile Gly Glu Asp Ser Ser Pro Leu Cys Phe Glu Asn Cys Gly 
                85                  90                  95      


Thr Val Gln Ser Ser Ala Ser Ala Thr Ile Thr Val Tyr Ser Phe Pro 
            100                 105                 110         


Glu Ser Val Glu Leu Arg Pro Leu Pro Ala Trp Gln Gln Val Gly Lys 
        115                 120                 125             


Asp Leu Thr Leu Arg Cys His Val Asp Gly Gly Ala Pro Arg Thr Gln 
    130                 135                 140                 


Leu Ser Ala Val Leu Leu Arg Gly Glu Glu Ile Leu Ser Arg Gln Pro 
145                 150                 155                 160 


Val Gly Gly His Pro Lys Asp Pro Lys Glu Ile Thr Phe Thr Val Leu 
                165                 170                 175     


Ala Ser Arg Gly Asp His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu 
            180                 185                 190         


Asp Leu Arg Pro Gln Gly Leu Ala Leu Phe Ser Asn Val Ser Glu Ala 
        195                 200                 205             


Arg Ser Leu Arg Thr Phe Asp Leu Pro Ala Thr Ile Pro Lys Leu Asp 
    210                 215                 220                 


Thr Pro Asp Leu Leu Glu Val Gly Thr Gln Gln Lys Leu Phe Cys Ser 
225                 230                 235                 240 


Leu Glu Gly Leu Phe Pro Ala Ser Glu Ala Arg Ile Tyr Leu Glu Leu 
                245                 250                 255     


Gly Gly Gln Met Pro Thr Gln Glu Ser Thr Asn Ser Ser Asp Ser Val 
            260                 265                 270         


Ser Ala Thr Ala Leu Val Glu Val Thr Glu Glu Phe Asp Arg Thr Leu 
        275                 280                 285             


Pro Leu Arg Cys Val Leu Glu Leu Ala Asp Gln Ile Leu Glu Thr Gln 
    290                 295                 300                 


Arg Thr Leu Thr Val Tyr Asn Phe Ser Ala Pro Val Leu Thr Leu Ser 
305                 310                 315                 320 


Gln Leu Glu Val Ser Glu Gly Ser Gln Val Thr Val Lys Cys Glu Ala 
                325                 330                 335     


His Ser Gly Ser Lys Val Val Leu Leu Ser Gly Val Glu Pro Arg Pro 
            340                 345                 350         


Pro Thr Pro Gln Val Gln Phe Thr Leu Asn Ala Ser Ser Glu Asp His 
        355                 360                 365             


Lys Arg Ser Phe Phe Cys Ser Ala Ala Leu Glu Val Ala Gly Lys Phe 
    370                 375                 380                 


Leu Phe Lys Asn Gln Thr Leu Glu Leu His Val Leu Tyr Gly Pro Arg 
385                 390                 395                 400 


Leu Asp Glu Thr Asp Cys Leu Gly Asn Trp Thr Trp Gln Glu Gly Ser 
                405                 410                 415     


Gln Gln Thr Leu Lys Cys Gln Ala Trp Gly Asn Pro Ser Pro Lys Met 
            420                 425                 430         


Thr Cys Arg Arg Lys Ala Asp Gly Ala Leu Leu Pro Ile Gly Val Val 
        435                 440                 445             


Lys Ser Val Lys Gln Glu Met Asn Gly Thr Tyr Val Cys His Ala Phe 
    450                 455                 460                 


Ser Ser His Gly Asn Val Thr Arg Asn Val Tyr Leu Thr Val Leu Tyr 
465                 470                 475                 480 


His Ser Gln Asn Asn Trp Thr Ile Ile Ile Leu Val Pro Val Leu Leu 
                485                 490                 495     


Val Ile Val Gly Leu Val Met Ala Ala Ser Tyr Val Tyr Asn Arg Gln 
            500                 505                 510         


Arg Lys Ile Arg Ile Tyr Lys Leu Gln Lys Ala Gln Glu Glu Ala Ile 
        515                 520                 525             


Lys Leu Lys Gly Gln Ala Pro Pro Pro 
    530                 535         


<210>  72
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Thr Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
    130                 135                 140                 


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
145                 150                 155                 160 


Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val Phe 
                165                 170                 175     


Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala Phe 
            180                 185                 190         


Lys His Lys Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
        195                 200                 205             


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Met Ile 
    210                 215                 220                 


Tyr His Cys Lys His Lys Leu 
225                 230     


<210>  73
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  74
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  74

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  75
<211>  228
<212>  PRT
<213>  Mus musculus

<400>  75

Met Gly Ala Trp Ala Met Leu Tyr Gly Val Ser Met Leu Cys Val Leu 
1               5                   10                  15      


Asp Leu Gly Gln Pro Ser Val Val Glu Glu Pro Gly Cys Gly Pro Gly 
            20                  25                  30          


Lys Val Gln Asn Gly Ser Gly Asn Asn Thr Arg Cys Cys Ser Leu Tyr 
        35                  40                  45              


Ala Pro Gly Lys Glu Asp Cys Pro Lys Glu Arg Cys Ile Cys Val Thr 
    50                  55                  60                  


Pro Glu Tyr His Cys Gly Asp Pro Gln Cys Lys Ile Cys Lys His Tyr 
65                  70                  75                  80  


Pro Cys Gln Pro Gly Gln Arg Val Glu Ser Gln Gly Asp Ile Val Phe 
                85                  90                  95      


Gly Phe Arg Cys Val Ala Cys Ala Met Gly Thr Phe Ser Ala Gly Arg 
            100                 105                 110         


Asp Gly His Cys Arg Leu Trp Thr Asn Cys Ser Gln Phe Gly Phe Leu 
        115                 120                 125             


Thr Met Phe Pro Gly Asn Lys Thr His Asn Ala Val Cys Ile Pro Glu 
    130                 135                 140                 


Pro Leu Pro Thr Glu Gln Tyr Gly His Leu Thr Val Ile Phe Leu Val 
145                 150                 155                 160 


Met Ala Ala Cys Ile Phe Phe Leu Thr Thr Val Gln Leu Gly Leu His 
                165                 170                 175     


Ile Trp Gln Leu Arg Arg Gln His Met Cys Pro Arg Glu Thr Gln Pro 
            180                 185                 190         


Phe Ala Glu Val Gln Leu Ser Ala Glu Asp Ala Cys Ser Phe Gln Phe 
        195                 200                 205             


Pro Glu Glu Glu Arg Gly Glu Gln Thr Glu Glu Lys Cys His Leu Gly 
    210                 215                 220                 


Gly Arg Trp Pro 
225             


<210>  76
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  77
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  77

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  78
<211>  79
<212>  PRT
<213>  Mus musculus

<400>  78

Met Asp Pro Pro Gly Tyr Leu Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ser Gln Thr Ser Ala Gly Ser Cys Ser Gly Cys Gly Thr Leu Ser 
            20                  25                  30          


Leu Pro Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Met Ser Leu 
        35                  40                  45              


Leu Ile Val Gly Val Val Phe Val Cys Met Arg Pro His Gly Arg Pro 
    50                  55                  60                  


Ala Gln Glu Asp Gly Arg Val Tyr Ile Asn Met Pro Gly Arg Gly 
65                  70                  75                  


<210>  79
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  80
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  80

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  81
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  81

Met Gly Ala Leu Glu Pro Ser Trp Cys Leu Leu Phe Leu Pro Val Leu 
1               5                   10                  15      


Leu Thr Val Gly Gly Leu Ser Pro Val Gln Ala Gln Ser Asp Thr Phe 
            20                  25                  30          


Pro Arg Cys Asp Cys Ser Ser Val Ser Pro Gly Val Leu Ala Gly Ile 
        35                  40                  45              


Val Leu Gly Asp Leu Val Leu Thr Leu Leu Ile Ala Leu Ala Val Tyr 
    50                  55                  60                  


Ser Leu Gly Arg Leu Val Ser Arg Gly Gln Gly Thr Ala Glu Gly Thr 
65                  70                  75                  80  


Arg Lys Gln His Ile Ala Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln 
                85                  90                  95      


Gly Gln Arg Pro Glu Val Tyr Ser Asp Leu Asn Thr Gln Arg Gln Tyr 
            100                 105                 110         


Tyr Arg 
        


<210>  82
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  83
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  83

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  84
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  84
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgc                             339


<210>  85
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly(A) sequence

<400>  85
aaataaaata cgaaatg                                                      17


<210>  86
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  86

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


