                         SEQUENCE LISTING

<110>  Akouos LLC
       McKenna, Michael
 
<120>  AAV-mediated Delivery of Therapeutic Antibodies to the Inner Ear

<130>  44628-0019WO1

<150>  US 62/607,665
<151>  2017-12-19

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  412
<212>  PRT
<213>  Human

<400>  1

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  2
<211>  1239
<212>  DNA
<213>  Human

<400>  2
ctgacggaca gacagacaga caccgccccc agccccagct accacctcct ccccggccgg       60

cggcggacag tggacgcggc ggcgagccgc gggcaggggc cggagcccgc gcccggaggc      120

ggggtggagg gggtcggggc tcgcggcgtc gcactgaaac ttttcgtcca acttctgggc      180

tgttctcgct tcggaggagc cgtggtccgc gcgggggaag ccgagccgag cggagccgcg      240

agaagtgcta gctcgggccg ggaggagccg cagccggagg agggggagga ggaagaagag      300

aaggaagagg agagggggcc gcagtggcga ctcggcgctc ggaagccggg ctcatggacg      360

ggtgaggcgg cggtgtgcgc agacagtgct ccagccgcgc gcgctcccca ggccctggcc      420

cgggcctcgg gccggggagg aagagtagct cgccgaggcg ccgaggagag cgggccgccc      480

cacagcccga gccggagagg gagcgcgagc cgcgccggcc ccggtcgggc ctccgaaacc      540

atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat      600

gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg      660

gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac      720

atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg      780

atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc      840

aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg      900

agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa      960

aaaaaatcag ttcgaggaaa gggaaagggg caaaaacgaa agcgcaagaa atcccggtat     1020

aagtcctgga gcgtgtacgt tggtgcccgc tgctgtctaa tgccctggag cctccctggc     1080

ccccatccct gtgggccttg ctcagagcgg agaaagcatt tgtttgtaca agatccgcag     1140

acgtgtaaat gttcctgcaa aaacacagac tcgcgttgca aggcgaggca gcttgagtta     1200

aacgaacgta cttgcagatg tgacaagccg aggcggtga                            1239


<210>  3
<211>  389
<212>  PRT
<213>  Human

<400>  3

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
            340                 345                 350         


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
        355                 360                 365             


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
    370                 375                 380                 


Asp Lys Pro Arg Arg 
385                 


<210>  4
<211>  1170
<212>  DNA
<213>  Human

<400>  4
ctgacggaca gacagacaga caccgccccc agccccagct accacctcct ccccggccgg       60

cggcggacag tggacgcggc ggcgagccgc gggcaggggc cggagcccgc gcccggaggc      120

ggggtggagg gggtcggggc tcgcggcgtc gcactgaaac ttttcgtcca acttctgggc      180

tgttctcgct tcggaggagc cgtggtccgc gcgggggaag ccgagccgag cggagccgcg      240

agaagtgcta gctcgggccg ggaggagccg cagccggagg agggggagga ggaagaagag      300

aaggaagagg agagggggcc gcagtggcga ctcggcgctc ggaagccggg ctcatggacg      360

ggtgaggcgg cggtgtgcgc agacagtgct ccagccgcgc gcgctcccca ggccctggcc      420

cgggcctcgg gccggggagg aagagtagct cgccgaggcg ccgaggagag cgggccgccc      480

cacagcccga gccggagagg gagcgcgagc cgcgccggcc ccggtcgggc ctccgaaacc      540

atgaactttc tgctgtcttg ggtgcattgg agccttgcct tgctgctcta cctccaccat      600

gccaagtggt cccaggctgc acccatggca gaaggaggag ggcagaatca tcacgaagtg      660

gtgaagttca tggatgtcta tcagcgcagc tactgccatc caatcgagac cctggtggac      720

atcttccagg agtaccctga tgagatcgag tacatcttca agccatcctg tgtgcccctg      780

atgcgatgcg ggggctgctg caatgacgag ggcctggagt gtgtgcccac tgaggagtcc      840

aacatcacca tgcagattat gcggatcaaa cctcaccaag gccagcacat aggagagatg      900

agcttcctac agcacaacaa atgtgaatgc agaccaaaga aagatagagc aagacaagaa      960

aaaaaatcag ttcgaggaaa gggaaagggg caaaaacgaa agcgcaagaa atcccgtccc     1020

tgtgggcctt gctcagagcg gagaaagcat ttgtttgtac aagatccgca gacgtgtaaa     1080

tgttcctgca aaaacacaga ctcgcgttgc aaggcgaggc agcttgagtt aaacgaacgt     1140

acttgcagat gtgacaagcc gaggcggtga                                      1170


<210>  5
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Bevacizumab light chain variable domain

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  6
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  Bevacizumab heavy chain variable domain

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  7
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Ranibizumab light chain variable domain

<400>  7

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  8
<211>  231
<212>  PRT
<213>  Artificial

<220>
<223>  Ranibizumab heavy chain variable domain

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu 
225                 230     


<210>  9
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Signal peptide

<400>  9

Met Glu Phe Phe Lys Lys Thr Ala Leu Ala Ala Leu Val Met Gly Phe 
1               5                   10                  15      


Ser Gly Ala Ala Leu Ala 
            20          


<210>  10
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Signal peptide

<400>  10

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  11
<211>  17
<212>  DNA
<213>  Human

<400>  11
aaataaaata cgaaatg                                                      17


<210>  12
<211>  431
<212>  PRT
<213>  Artificial

<220>
<223>  Aflibercept

<400>  12

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430     


<210>  13
<211>  206
<212>  PRT
<213>  Human

<400>  13

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys 
        115                 120                 125             


Arg Lys Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg 
    130                 135                 140                 


Cys Cys Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro 
145                 150                 155                 160 


Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys 
                165                 170                 175     


Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu 
            180                 185                 190         


Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
        195                 200                 205     


<210>  14
<211>  186
<212>  PRT
<213>  Human

<400>  14

Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln Arg Lys Val Val Ser 
1               5                   10                  15      


Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln Pro Arg Glu Val Val 
            20                  25                  30          


Val Pro Leu Thr Val Glu Leu Met Gly Thr Val Ala Lys Gln Leu Val 
        35                  40                  45              


Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly Cys Cys Pro Asp Asp 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln Val Arg Met Gln Ile 
65                  70                  75                  80  


Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly Glu Met Ser Leu Glu 
                85                  90                  95      


Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys Lys Asp Ser Ala Val 
            100                 105                 110         


Lys Pro Asp Arg Ala Ala Thr Pro His His Arg Pro Gln Pro Arg Ser 
        115                 120                 125             


Val Pro Gly Trp Asp Ser Ala Pro Gly Ala Pro Ser Pro Ala Asp Ile 
    130                 135                 140                 


Thr His Pro Thr Pro Ala Pro Gly Pro Ser Ala His Ala Ala Pro Ser 
145                 150                 155                 160 


Thr Thr Ser Ala Leu Thr Pro Gly Pro Ala Ala Ala Ala Ala Asp Ala 
                165                 170                 175     


Ala Ala Ser Ser Val Ala Lys Gly Gly Ala 
            180                 185     


<210>  15
<211>  116
<212>  PRT
<213>  Human

<400>  15

Ala His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg 
1               5                   10                  15      


Lys Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu 
            20                  25                  30          


Phe Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val 
        35                  40                  45              


Tyr Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn 
    50                  55                  60                  


Thr Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro 
65                  70                  75                  80  


Leu Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr 
                85                  90                  95      


Ser Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser 
            100                 105                 110         


Ile Ile Arg Arg 
        115     


<210>  16
<211>  117
<212>  PRT
<213>  Human

<400>  16

Phe Ala Ala Thr Phe Tyr Asp Ile Glu Thr Leu Lys Val Ile Asp Glu 
1               5                   10                  15      


Glu Trp Gln Arg Thr Gln Cys Ser Pro Arg Glu Thr Cys Val Glu Val 
            20                  25                  30          


Ala Ser Glu Leu Gly Lys Ser Thr Asn Thr Phe Phe Lys Pro Pro Cys 
        35                  40                  45              


Val Asn Val Phe Arg Cys Gly Gly Cys Cys Asn Glu Glu Ser Leu Ile 
    50                  55                  60                  


Cys Met Asn Thr Ser Thr Ser Tyr Ile Ser Lys Gln Leu Phe Glu Ile 
65                  70                  75                  80  


Ser Val Pro Leu Thr Ser Val Pro Glu Leu Val Pro Val Lys Val Ala 
                85                  90                  95      


Asn His Thr Gly Cys Lys Cys Leu Pro Thr Ala Pro Arg His Pro Tyr 
            100                 105                 110         


Ser Ile Ile Arg Arg 
        115         


<210>  17
<211>  687
<212>  PRT
<213>  Human

<400>  17

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Gly Glu His Cys Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe 
            660                 665                 670         


Lys Ser Thr Arg Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His 
        675                 680                 685         


<210>  18
<211>  2064
<212>  DNA
<213>  Human

<400>  18
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag      120

cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa      180

tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc      240

tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac      300

cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca      360

gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt      420

gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt      480

acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat      540

ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa      600

gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat      660

ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc      720

aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg      780

agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga      840

cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa      900

atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa      960

tctgttaaca cctcagtgca tatatatgat aaagcattca tcactgtgaa acatcgaaaa     1020

cagcaggtgc ttgaaaccgt agctggcaag cggtcttacc ggctctctat gaaagtgaag     1080

gcatttccct cgccggaagt tgtatggtta aaagatgggt tacctgcgac tgagaaatct     1140

gctcgctatt tgactcgtgg ctactcgtta attatcaagg acgtaactga agaggatgca     1200

gggaattata caatcttgct gagcataaaa cagtcaaatg tgtttaaaaa cctcactgcc     1260

actctaattg tcaatgtgaa accccagatt tacgaaaagg ccgtgtcatc gtttccagac     1320

ccggctctct acccactggg cagcagacaa atcctgactt gtaccgcata tggtatccct     1380

caacctacaa tcaagtggtt ctggcacccc tgtaaccata atcattccga agcaaggtgt     1440

gacttttgtt ccaataatga agagtccttt atcctggatg ctgacagcaa catgggaaac     1500

agaattgaga gcatcactca gcgcatggca ataatagaag gaaagaataa gatggctagc     1560

accttggttg tggctgactc tagaatttct ggaatctaca tttgcatagc ttccaataaa     1620

gttgggactg tgggaagaaa cataagcttt tatatcacag atgtgccaaa tgggtttcat     1680

gttaacttgg aaaaaatgcc gacggaagga gaggacctga aactgtcttg cacagttaac     1740

aagttcttat acagagacgt tacttggatt ttactgcgga cagttaataa cagaacaatg     1800

cactacagta ttagcaagca aaaaatggcc atcactaagg agcactccat cactcttaat     1860

cttaccatca tgaatgtttc cctgcaagat tcaggcacct atgcctgcag agccaggaat     1920

gtatacacag gggaagaaat cctccagaag aaagaaatta caatcagagg tgagcactgc     1980

aacaaaaagg ctgttttctc tcggatctcc aaatttaaaa gcacaaggaa tgattgtacc     2040

acacaaagta atgtaaaaca ttaa                                            2064


<210>  19
<211>  733
<212>  PRT
<213>  Human

<400>  19

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Glu Leu Tyr Thr Ser Thr Ser Pro Ser Ser Ser Ser Ser Ser Pro 
705                 710                 715                 720 


Leu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                725                 730             


<210>  20
<211>  2202
<212>  DNA
<213>  Human

<400>  20
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag      120

cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa      180

tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc      240

tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac      300

cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca      360

gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt      420

gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt      480

acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat      540

ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa      600

gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat      660

ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc      720

aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg      780

agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga      840

cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa      900

atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa      960

tctgttaaca cctcagtgca tatatatgat aaagcattca tcactgtgaa acatcgaaaa     1020

cagcaggtgc ttgaaaccgt agctggcaag cggtcttacc ggctctctat gaaagtgaag     1080

gcatttccct cgccggaagt tgtatggtta aaagatgggt tacctgcgac tgagaaatct     1140

gctcgctatt tgactcgtgg ctactcgtta attatcaagg acgtaactga agaggatgca     1200

gggaattata caatcttgct gagcataaaa cagtcaaatg tgtttaaaaa cctcactgcc     1260

actctaattg tcaatgtgaa accccagatt tacgaaaagg ccgtgtcatc gtttccagac     1320

ccggctctct acccactggg cagcagacaa atcctgactt gtaccgcata tggtatccct     1380

caacctacaa tcaagtggtt ctggcacccc tgtaaccata atcattccga agcaaggtgt     1440

gacttttgtt ccaataatga agagtccttt atcctggatg ctgacagcaa catgggaaac     1500

agaattgaga gcatcactca gcgcatggca ataatagaag gaaagaataa gatggctagc     1560

accttggttg tggctgactc tagaatttct ggaatctaca tttgcatagc ttccaataaa     1620

gttgggactg tgggaagaaa cataagcttt tatatcacag atgtgccaaa tgggtttcat     1680

gttaacttgg aaaaaatgcc gacggaagga gaggacctga aactgtcttg cacagttaac     1740

aagttcttat acagagacgt tacttggatt ttactgcgga cagttaataa cagaacaatg     1800

cactacagta ttagcaagca aaaaatggcc atcactaagg agcactccat cactcttaat     1860

cttaccatca tgaatgtttc cctgcaagat tcaggcacct atgcctgcag agccaggaat     1920

gtatacacag gggaagaaat cctccagaag aaagaaatta caatcagaga tcaggaagca     1980

ccatacctcc tgcgaaacct cagtgatcac acagtggcca tcagcagttc caccacttta     2040

gactgtcatg ctaatggtgt ccccgagcct cagatcactt ggtttaaaaa caaccacaaa     2100

atacaacaag agcctgaact gtatacatca acgtcaccat cgtcatcgtc atcatcacca     2160

ttgtcatcat catcatcatc gtcatcatca tcatcatcat ag                        2202


<210>  21
<211>  541
<212>  PRT
<213>  Human

<400>  21

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn Ser Ser Phe Met Leu Pro 
        515                 520                 525             


Pro Thr Ser Phe Ser Ser Asn Tyr Phe His Phe Leu Pro 
    530                 535                 540     


<210>  22
<211>  1626
<212>  DNA
<213>  Human

<400>  22
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag      120

cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa      180

tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc      240

tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac      300

cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca      360

gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt      420

gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt      480

acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat      540

ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa      600

gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat      660

ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc      720

aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg      780

agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga      840

cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa      900

atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa      960

tctgttaaca cctcagtgca tatatatgat aaagcattca tcactgtgaa acatcgaaaa     1020

cagcaggtgc ttgaaaccgt agctggcaag cggtcttacc ggctctctat gaaagtgaag     1080

gcatttccct cgccggaagt tgtatggtta aaagatgggt tacctgcgac tgagaaatct     1140

gctcgctatt tgactcgtgg ctactcgtta attatcaagg acgtaactga agaggatgca     1200

gggaattata caatcttgct gagcataaaa cagtcaaatg tgtttaaaaa cctcactgcc     1260

actctaattg tcaatgtgaa accccagatt tacgaaaagg ccgtgtcatc gtttccagac     1320

ccggctctct acccactggg cagcagacaa atcctgactt gtaccgcata tggtatccct     1380

caacctacaa tcaagtggtt ctggcacccc tgtaaccata atcattccga agcaaggtgt     1440

gacttttgtt ccaataatga agagtccttt atcctggatg ctgacagcaa catgggaaac     1500

agaattgaga gcatcactca gcgcatggca ataatagaag gaaagaataa gcttccacca     1560

gctaacagtt ctttcatgtt gccacctaca agcttctctt ccaactactt ccatttcctt     1620

ccgtga                                                                1626


<210>  23
<211>  732
<212>  PRT
<213>  Human

<400>  23

Ser Lys Leu Lys Asp Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile 
1               5                   10                  15      


Met Gln Ala Gly Gln Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala 
            20                  25                  30          


His Lys Trp Ser Leu Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu 
        35                  40                  45              


Ser Ile Thr Lys Ser Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser 
    50                  55                  60                  


Thr Leu Thr Leu Asn Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser 
65                  70                  75                  80  


Cys Lys Tyr Leu Ala Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser 
                85                  90                  95      


Ala Ile Tyr Ile Phe Ile Ser Asp Thr Gly Arg Pro Phe Val Glu Met 
            100                 105                 110         


Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu 
        115                 120                 125             


Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys 
    130                 135                 140                 


Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp 
145                 150                 155                 160 


Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile 
                165                 170                 175     


Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr 
            180                 185                 190         


Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Gln Ile 
        195                 200                 205             


Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu 
    210                 215                 220                 


Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp 
225                 230                 235                 240 


Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile 
                245                 250                 255     


Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile 
            260                 265                 270         


Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg 
        275                 280                 285             


Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp 
    290                 295                 300                 


Lys Ala Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr 
305                 310                 315                 320 


Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe 
                325                 330                 335     


Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu 
            340                 345                 350         


Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp 
        355                 360                 365             


Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys 
    370                 375                 380                 


Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val 
385                 390                 395                 400 


Lys Pro Gln Ile Tyr Glu Lys Ala Val Ser Ser Phe Pro Asp Pro Ala 
                405                 410                 415     


Leu Tyr Pro Leu Gly Ser Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly 
            420                 425                 430         


Ile Pro Gln Pro Thr Ile Lys Trp Phe Trp His Pro Cys Asn His Asn 
        435                 440                 445             


His Ser Glu Ala Arg Cys Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe 
    450                 455                 460                 


Ile Leu Asp Ala Asp Ser Asn Met Gly Asn Arg Ile Glu Ser Ile Thr 
465                 470                 475                 480 


Gln Arg Met Ala Ile Ile Glu Gly Lys Asn Lys Met Ala Ser Thr Leu 
                485                 490                 495     


Val Val Ala Asp Ser Arg Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser 
            500                 505                 510         


Asn Lys Val Gly Thr Val Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp 
        515                 520                 525             


Val Pro Asn Gly Phe His Val Asn Leu Glu Lys Met Pro Thr Glu Gly 
    530                 535                 540                 


Glu Asp Leu Lys Leu Ser Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp 
545                 550                 555                 560 


Val Thr Trp Ile Leu Leu Arg Thr Val Asn Asn Arg Thr Met His Tyr 
                565                 570                 575     


Ser Ile Ser Lys Gln Lys Met Ala Ile Thr Lys Glu His Ser Ile Thr 
            580                 585                 590         


Leu Asn Leu Thr Ile Met Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr 
        595                 600                 605             


Ala Cys Arg Ala Arg Asn Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys 
    610                 615                 620                 


Lys Glu Ile Thr Ile Arg Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn 
625                 630                 635                 640 


Leu Ser Asp His Thr Val Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys 
                645                 650                 655     


His Ala Asn Gly Val Pro Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn 
            660                 665                 670         


His Lys Ile Gln Gln Glu Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser 
        675                 680                 685             


Thr Leu Phe Ile Glu Arg Val Thr Glu Glu Asp Glu Gly Val Tyr His 
    690                 695                 700                 


Cys Lys Ala Thr Asn Gln Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu 
705                 710                 715                 720 


Thr Val Gln Gly Thr Ser Asp Lys Ser Asn Leu Glu 
                725                 730         


<210>  24
<211>  737
<212>  PRT
<213>  Mouse

<400>  24

Tyr Gly Ser Gly Ser Lys Leu Lys Val Pro Glu Leu Ser Leu Lys Gly 
1               5                   10                  15      


Thr Gln His Val Met Gln Ala Gly Gln Thr Leu Phe Leu Lys Cys Arg 
            20                  25                  30          


Gly Glu Ala Ala His Ser Trp Ser Leu Pro Thr Thr Val Ser Gln Glu 
        35                  40                  45              


Asp Lys Arg Leu Ser Ile Thr Pro Pro Ser Ala Cys Gly Arg Asp Asn 
    50                  55                  60                  


Arg Gln Phe Cys Ser Thr Leu Thr Leu Asp Thr Ala Gln Ala Asn His 
65                  70                  75                  80  


Thr Gly Leu Tyr Thr Cys Arg Tyr Leu Pro Thr Ser Thr Ser Lys Lys 
                85                  90                  95      


Lys Lys Ala Glu Ser Ser Ile Tyr Ile Phe Val Ser Asp Ala Gly Ser 
            100                 105                 110         


Pro Phe Ile Glu Met His Thr Asp Ile Pro Lys Leu Val His Met Thr 
        115                 120                 125             


Glu Gly Arg Gln Leu Ile Ile Pro Cys Arg Val Thr Ser Pro Asn Val 
    130                 135                 140                 


Thr Val Thr Leu Lys Lys Phe Pro Phe Asp Thr Leu Thr Pro Asp Gly 
145                 150                 155                 160 


Gln Arg Ile Thr Trp Asp Ser Arg Arg Gly Phe Ile Ile Ala Asn Ala 
                165                 170                 175     


Thr Tyr Lys Glu Ile Gly Leu Leu Asn Cys Glu Ala Thr Val Asn Gly 
            180                 185                 190         


His Leu Tyr Gln Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile 
        195                 200                 205             


Leu Asp Val Gln Ile Arg Pro Pro Ser Pro Val Arg Leu Leu His Gly 
    210                 215                 220                 


Gln Thr Leu Val Leu Asn Cys Thr Ala Thr Thr Glu Leu Asn Thr Arg 
225                 230                 235                 240 


Val Gln Met Ser Trp Asn Tyr Pro Gly Lys Ala Thr Lys Arg Ala Ser 
                245                 250                 255     


Ile Arg Gln Arg Ile Asp Arg Ser His Ser His Asn Asn Val Phe His 
            260                 265                 270         


Ser Val Leu Lys Ile Asn Asn Val Glu Ser Arg Asp Lys Gly Leu Tyr 
        275                 280                 285             


Thr Cys Arg Val Lys Ser Gly Ser Ser Phe Gln Ser Phe Asn Thr Ser 
    290                 295                 300                 


Val His Val Tyr Glu Lys Gly Phe Ile Ser Val Lys His Arg Lys Gln 
305                 310                 315                 320 


Pro Val Gln Glu Thr Thr Ala Gly Arg Arg Ser Tyr Arg Leu Ser Met 
                325                 330                 335     


Lys Val Lys Ala Phe Pro Ser Pro Glu Ile Val Trp Leu Lys Asp Gly 
            340                 345                 350         


Ser Pro Ala Thr Leu Lys Ser Ala Arg Tyr Leu Val His Gly Tyr Ser 
        355                 360                 365             


Leu Ile Ile Lys Asp Val Thr Thr Glu Asp Ala Gly Asp Tyr Thr Ile 
    370                 375                 380                 


Leu Leu Gly Ile Lys Gln Ser Arg Leu Phe Lys Asn Leu Thr Ala Thr 
385                 390                 395                 400 


Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu Lys Ser Val Ser Ser 
                405                 410                 415     


Leu Pro Ser Pro Pro Leu Tyr Pro Leu Gly Ser Arg Gln Val Leu Thr 
            420                 425                 430         


Cys Thr Val Tyr Gly Ile Pro Arg Pro Thr Ile Thr Trp Leu Trp His 
        435                 440                 445             


Pro Cys His His Asn His Ser Lys Glu Arg Tyr Asp Phe Cys Thr Glu 
    450                 455                 460                 


Asn Glu Glu Ser Phe Ile Leu Asp Pro Ser Ser Asn Leu Gly Asn Arg 
465                 470                 475                 480 


Ile Glu Ser Ile Ser Gln Arg Met Thr Val Ile Glu Gly Thr Asn Lys 
                485                 490                 495     


Thr Val Ser Thr Leu Val Val Ala Asp Ser Gln Thr Pro Gly Ile Tyr 
            500                 505                 510         


Ser Cys Arg Ala Phe Asn Lys Ile Gly Thr Val Glu Arg Asn Ile Lys 
        515                 520                 525             


Phe Tyr Val Thr Asp Val Pro Asn Gly Phe His Val Ser Leu Glu Lys 
    530                 535                 540                 


Met Pro Ala Glu Gly Glu Asp Leu Lys Leu Ser Cys Val Val Asn Lys 
545                 550                 555                 560 


Phe Leu Tyr Arg Asp Ile Thr Trp Ile Leu Leu Arg Thr Val Asn Asn 
                565                 570                 575     


Arg Thr Met His His Ser Ile Ser Lys Gln Lys Met Ala Thr Thr Gln 
            580                 585                 590         


Asp Tyr Ser Ile Thr Leu Asn Leu Val Ile Lys Asn Val Ser Leu Glu 
        595                 600                 605             


Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn Ile Tyr Thr Gly Glu 
    610                 615                 620                 


Asp Ile Leu Arg Lys Thr Glu Val Leu Val Arg Asp Ser Glu Ala Pro 
625                 630                 635                 640 


His Leu Leu Gln Asn Leu Ser Asp Tyr Glu Val Ser Ile Ser Gly Ser 
                645                 650                 655     


Thr Thr Leu Asp Cys Gln Ala Arg Gly Val Pro Ala Pro Gln Ile Thr 
            660                 665                 670         


Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu Pro Gly Ile Ile Leu 
        675                 680                 685             


Gly Pro Gly Asn Ser Thr Leu Phe Ile Glu Arg Val Thr Glu Glu Asp 
    690                 695                 700                 


Glu Gly Val Tyr Arg Cys Arg Ala Thr Asn Gln Lys Gly Ala Val Glu 
705                 710                 715                 720 


Ser Ala Ala Tyr Leu Thr Val Gln Gly Thr Ser Asp Lys Ser Asn Leu 
                725                 730                 735     


Glu 
    


<210>  25
<211>  736
<212>  PRT
<213>  Rat

<400>  25

Tyr Cys Ser Gly Ser Lys Leu Lys Gly Pro Glu Leu Ser Leu Lys Gly 
1               5                   10                  15      


Thr Gln His Val Met Gln Ala Gly Gln Thr Leu Phe Leu Lys Cys Arg 
            20                  25                  30          


Gly Glu Ala Ala His Ser Trp Ser Leu Pro Thr Thr Val Ser Gln Glu 
        35                  40                  45              


Asp Lys Lys Leu Ser Val Thr Arg Ser Ala Cys Gly Arg Asn Asn Arg 
    50                  55                  60                  


Gln Phe Cys Ser Thr Leu Thr Leu Asn Met Ala Gln Ala Asn His Thr 
65                  70                  75                  80  


Gly Leu Tyr Ser Cys Arg Tyr Leu Pro Lys Ser Thr Ser Lys Glu Lys 
                85                  90                  95      


Lys Met Glu Ser Ala Ile Tyr Ile Phe Val Ser Asp Ala Gly Ser Pro 
            100                 105                 110         


Phe Ile Glu Met His Ser Asp Ile Pro Lys Leu Val His Met Thr Glu 
        115                 120                 125             


Gly Arg Glu Leu Ile Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr 
    130                 135                 140                 


Val Thr Leu Lys Lys Phe Pro Phe Asp Ala Leu Thr Pro Asp Gly Gln 
145                 150                 155                 160 


Arg Ile Ala Trp Asp Ser Arg Arg Gly Phe Ile Ile Ala Asn Ala Thr 
                165                 170                 175     


Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His 
            180                 185                 190         


Leu Tyr Gln Thr Ser Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Leu 
        195                 200                 205             


Asp Val Gln Ile Ser Pro Pro Ser Pro Val Arg Phe Leu Arg Gly Gln 
    210                 215                 220                 


Thr Leu Val Leu Asn Cys Thr Val Thr Thr Asp Leu Asn Thr Arg Val 
225                 230                 235                 240 


Gln Met Ser Trp Asn Tyr Pro Gly Lys Ala Thr Lys Arg Ala Ser Ile 
                245                 250                 255     


Arg Gln Arg Ile Asp Gln Ser Asn Pro His Ser Asn Val Phe His Ser 
            260                 265                 270         


Val Leu Lys Ile Asn Asn Val Glu Ser Arg Asp Lys Gly Leu Tyr Thr 
        275                 280                 285             


Cys Arg Val Lys Ser Gly Ser Ser Phe Arg Thr Phe Asn Thr Ser Val 
    290                 295                 300                 


His Val Tyr Glu Lys Gly Phe Ile Ser Val Lys His Arg Lys Gln Gln 
305                 310                 315                 320 


Val Gln Glu Thr Ile Ala Gly Lys Arg Ser His Arg Leu Ser Met Lys 
                325                 330                 335     


Val Lys Ala Phe Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Val 
            340                 345                 350         


Pro Ala Thr Glu Lys Ser Ala Arg Tyr Ser Val His Gly Tyr Ser Leu 
        355                 360                 365             


Ile Ile Lys Asp Val Thr Ala Glu Asp Ala Gly Asp Tyr Thr Ile Leu 
    370                 375                 380                 


Leu Gly Ile Lys Gln Ser Lys Leu Phe Arg Asn Leu Thr Ala Thr Leu 
385                 390                 395                 400 


Ile Val Asn Val Lys Pro Gln Ile Tyr Glu Lys Ser Val Ser Ser Leu 
                405                 410                 415     


Pro Ser Pro Pro Leu Tyr Pro Leu Gly Ser Arg Gln Val Leu Thr Cys 
            420                 425                 430         


Thr Val Tyr Gly Ile Pro Gln Pro Thr Ile Lys Trp Leu Trp His Pro 
        435                 440                 445             


Cys His Tyr Asn His Ser Lys Glu Arg Asn Asp Phe Cys Phe Gly Ser 
    450                 455                 460                 


Glu Glu Ser Phe Ile Leu Asp Ser Ser Ser Asn Ile Gly Asn Arg Ile 
465                 470                 475                 480 


Glu Gly Ile Thr Gln Arg Met Met Val Ile Glu Gly Thr Asn Lys Thr 
                485                 490                 495     


Val Ser Thr Leu Val Val Ala Asp Ser Arg Thr Pro Gly Ser Tyr Ser 
            500                 505                 510         


Cys Lys Ala Phe Asn Lys Ile Gly Thr Val Glu Arg Asp Ile Arg Phe 
        515                 520                 525             


Tyr Val Thr Asp Val Pro Asn Gly Phe His Val Ser Leu Glu Lys Ile 
    530                 535                 540                 


Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser Cys Val Val Ser Lys Phe 
545                 550                 555                 560 


Leu Tyr Arg Asp Ile Thr Trp Ile Leu Leu Arg Thr Val Asn Asn Arg 
                565                 570                 575     


Thr Met His His Ser Ile Ser Lys Gln Lys Met Ala Thr Thr Gln Asp 
            580                 585                 590         


Tyr Ser Ile Thr Leu Asn Leu Val Ile Lys Asn Val Ser Leu Glu Asp 
        595                 600                 605             


Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn Ile Tyr Thr Gly Glu Glu 
    610                 615                 620                 


Ile Leu Arg Lys Thr Glu Val Leu Val Arg Asp Leu Glu Ala Pro Leu 
625                 630                 635                 640 


Leu Leu Gln Asn Leu Ser Asp His Glu Val Ser Ile Ser Gly Ser Thr 
                645                 650                 655     


Thr Leu Asp Cys Gln Ala Arg Gly Val Pro Ala Pro Gln Ile Thr Trp 
            660                 665                 670         


Phe Lys Asn Asn His Lys Ile Gln Gln Glu Pro Gly Ile Ile Leu Gly 
        675                 680                 685             


Pro Gly Asn Ser Thr Leu Phe Ile Glu Arg Val Thr Glu Glu Asp Glu 
    690                 695                 700                 


Gly Val Tyr Arg Cys Arg Ala Thr Asn Gln Lys Gly Val Val Glu Ser 
705                 710                 715                 720 


Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser Asp Lys Ser Asn Leu Glu 
                725                 730                 735     


<210>  26
<211>  745
<212>  PRT
<213>  Human

<400>  26

Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro Arg Leu Ser 
1               5                   10                  15      


Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr Leu Gln Ile 
            20                  25                  30          


Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro Asn Asn Gln 
        35                  40                  45              


Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser Asp Gly Leu 
    50                  55                  60                  


Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn Asp Thr Gly 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser Val Ile Tyr 
                85                  90                  95      


Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser Val Ser Asp 
            100                 105                 110         


Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys Thr Val Val 
        115                 120                 125             


Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser Leu Cys Ala 
    130                 135                 140                 


Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg Ile Ser Trp 
145                 150                 155                 160 


Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile Ser Tyr Ala 
                165                 170                 175     


Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser Tyr Gln Ser 
            180                 185                 190         


Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr Asp Val Val 
        195                 200                 205             


Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val 
    210                 215                 220                 


Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn 
225                 230                 235                 240 


Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg 
                245                 250                 255     


Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr 
            260                 265                 270         


Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys 
        275                 280                 285             


Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg 
    290                 295                 300                 


Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met Glu Ser Leu 
305                 310                 315                 320 


Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala Lys Tyr Leu 
                325                 330                 335     


Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly Ile Pro Leu 
            340                 345                 350         


Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr Ile Met Glu 
        355                 360                 365             


Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu Thr Asn Pro 
    370                 375                 380                 


Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val Val Tyr Val 
385                 390                 395                 400 


Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val Asp Ser Tyr 
                405                 410                 415     


Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr Ala Ile Pro 
            420                 425                 430         


Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu Glu Cys Ala 
        435                 440                 445             


Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr Pro Cys Glu 
    450                 455                 460                 


Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys Ile Glu Val 
465                 470                 475                 480 


Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys Thr Val Ser 
                485                 490                 495     


Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr Lys Cys Glu 
            500                 505                 510         


Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser Phe His Val 
        515                 520                 525             


Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln Pro Thr Glu 
    530                 535                 540                 


Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser Thr Phe Glu 
545                 550                 555                 560 


Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro Ile His Val 
                565                 570                 575     


Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr Leu Trp Lys 
            580                 585                 590         


Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile Leu Ile Met 
        595                 600                 605             


Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr Val Cys Leu 
    610                 615                 620                 


Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val Arg Gln Leu 
625                 630                 635                 640 


Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn Leu Glu Asn 
                645                 650                 655     


Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys Thr Ala Ser 
            660                 665                 670         


Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn Glu Thr Leu 
        675                 680                 685             


Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg Asn Leu Thr 
    690                 695                 700                 


Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr Cys Gln Ala 
705                 710                 715                 720 


Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe Ile Ile Glu 
                725                 730                 735     


Gly Ala Gln Glu Lys Thr Asn Leu Glu 
            740                 745 


<210>  27
<211>  743
<212>  PRT
<213>  Mouse

<400>  27

Ala Ser Val Gly Leu Pro Gly Asp Phe Leu His Pro Pro Lys Leu Ser 
1               5                   10                  15      


Thr Gln Lys Asp Ile Leu Thr Ile Leu Ala Asn Thr Thr Leu Gln Ile 
            20                  25                  30          


Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro Asn Ala Gln 
        35                  40                  45              


Arg Asp Ser Glu Glu Arg Val Leu Val Thr Glu Cys Gly Gly Gly Asp 
    50                  55                  60                  


Ser Ile Phe Cys Lys Thr Leu Thr Ile Pro Arg Val Val Gly Asn Asp 
65                  70                  75                  80  


Thr Gly Ala Tyr Lys Cys Ser Tyr Arg Asp Val Asp Ile Ala Ser Thr 
                85                  90                  95      


Val Tyr Val Tyr Val Arg Asp Tyr Arg Ser Pro Phe Ile Ala Ser Val 
            100                 105                 110         


Ser Asp Gln His Gly Ile Val Tyr Ile Thr Glu Asn Lys Asn Lys Thr 
        115                 120                 125             


Val Val Ile Pro Cys Arg Gly Ser Ile Ser Asn Leu Asn Val Ser Leu 
    130                 135                 140                 


Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg Ile 
145                 150                 155                 160 


Ser Trp Asp Ser Glu Ile Gly Phe Thr Leu Pro Ser Tyr Met Ile Ser 
                165                 170                 175     


Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Thr Tyr 
            180                 185                 190         


Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr Asp 
        195                 200                 205             


Val Ile Leu Ser Pro Pro His Glu Ile Glu Leu Ser Ala Gly Glu Lys 
    210                 215                 220                 


Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Leu Asp 
225                 230                 235                 240 


Phe Thr Trp His Ser Pro Pro Ser Lys Ser His His Lys Lys Ile Val 
                245                 250                 255     


Asn Arg Asp Val Lys Pro Phe Pro Gly Thr Val Ala Lys Met Phe Leu 
            260                 265                 270         


Ser Thr Leu Thr Ile Glu Ser Val Thr Lys Ser Asp Gln Gly Glu Tyr 
        275                 280                 285             


Thr Cys Val Ala Ser Ser Gly Arg Met Ile Lys Arg Asn Arg Thr Phe 
    290                 295                 300                 


Val Arg Val His Thr Lys Pro Phe Ile Ala Phe Gly Ser Gly Met Lys 
305                 310                 315                 320 


Ser Leu Val Glu Ala Thr Val Gly Ser Gln Val Arg Ile Pro Val Lys 
                325                 330                 335     


Tyr Leu Ser Tyr Pro Ala Pro Asp Ile Lys Trp Tyr Arg Asn Gly Arg 
            340                 345                 350         


Pro Ile Glu Ser Asn Tyr Thr Met Ile Val Gly Asp Glu Leu Thr Ile 
        355                 360                 365             


Met Glu Val Thr Glu Arg Asp Ala Gly Asn Tyr Thr Val Ile Leu Thr 
    370                 375                 380                 


Asn Pro Ile Ser Met Glu Lys Gln Ser His Met Val Ser Leu Val Val 
385                 390                 395                 400 


Asn Val Pro Pro Gln Ile Gly Glu Lys Ala Leu Ile Ser Pro Met Asp 
                405                 410                 415     


Ser Tyr Gln Tyr Gly Thr Met Gln Thr Leu Thr Cys Thr Val Tyr Ala 
            420                 425                 430         


Asn Pro Pro Leu His His Ile Gln Trp Tyr Trp Gln Leu Glu Glu Ala 
        435                 440                 445             


Cys Ser Tyr Arg Pro Gly Gln Thr Ser Pro Tyr Ala Cys Lys Glu Trp 
    450                 455                 460                 


Arg His Val Glu Asp Phe Gln Gly Gly Asn Lys Ile Glu Val Thr Lys 
465                 470                 475                 480 


Asn Gln Tyr Ala Leu Ile Glu Gly Lys Asn Lys Thr Val Ser Thr Leu 
                485                 490                 495     


Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr Lys Cys Glu Ala Ile 
            500                 505                 510         


Asn Lys Ala Gly Arg Gly Glu Arg Val Ile Ser Phe His Val Ile Arg 
        515                 520                 525             


Gly Pro Glu Ile Thr Val Gln Pro Ala Ala Gln Pro Thr Glu Gln Glu 
    530                 535                 540                 


Ser Val Ser Leu Leu Cys Thr Ala Asp Arg Asn Thr Phe Glu Asn Leu 
545                 550                 555                 560 


Thr Trp Tyr Lys Leu Gly Ser Gln Ala Thr Ser Val His Met Gly Glu 
                565                 570                 575     


Ser Leu Thr Pro Val Cys Lys Asn Leu Asp Ala Leu Trp Lys Leu Asn 
            580                 585                 590         


Gly Thr Met Phe Ser Asn Ser Thr Asn Asp Ile Leu Ile Val Ala Phe 
        595                 600                 605             


Gln Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr Val Cys Ser Ala Gln 
    610                 615                 620                 


Asp Lys Lys Thr Lys Lys Arg His Cys Leu Val Lys Gln Leu Ile Ile 
625                 630                 635                 640 


Leu Glu Arg Met Ala Pro Met Ile Thr Gly Asn Leu Glu Asn Gln Thr 
                645                 650                 655     


Thr Thr Ile Gly Glu Thr Ile Glu Val Thr Cys Pro Ala Ser Gly Asn 
            660                 665                 670         


Pro Thr Pro His Ile Thr Trp Phe Lys Asp Asn Glu Thr Leu Val Glu 
        675                 680                 685             


Asp Ser Gly Ile Val Leu Arg Asp Gly Asn Arg Asn Leu Thr Ile Arg 
    690                 695                 700                 


Arg Val Arg Lys Glu Asp Gly Gly Leu Tyr Thr Cys Gln Ala Cys Asn 
705                 710                 715                 720 


Val Leu Gly Cys Ala Arg Ala Glu Thr Leu Phe Ile Ile Glu Gly Ala 
                725                 730                 735     


Gln Glu Lys Thr Asn Leu Glu 
            740             


<210>  28
<211>  741
<212>  PRT
<213>  Rat

<400>  28

Ala Ser Val Gly Leu Pro Gly Asp Ser Leu His Pro Pro Lys Leu Ser 
1               5                   10                  15      


Thr Gln Lys Asp Ile Leu Thr Ile Leu Ala Asn Thr Thr Leu Gln Ile 
            20                  25                  30          


Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro Asn Thr Pro 
        35                  40                  45              


Arg Asp Ser Glu Glu Arg Val Leu Val Thr Glu Cys Gly Asp Ser Ile 
    50                  55                  60                  


Phe Cys Lys Thr Leu Thr Val Pro Arg Val Val Gly Asn Asp Thr Gly 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Tyr Arg Asp Thr Asp Val Ser Ser Ile Val Tyr 
                85                  90                  95      


Val Tyr Val Gln Asp His Arg Ser Pro Phe Ile Ala Ser Val Ser Asp 
            100                 105                 110         


Glu His Gly Ile Val Tyr Ile Thr Glu Asn Lys Asn Lys Thr Val Val 
        115                 120                 125             


Ile Pro Cys Arg Gly Ser Ile Ser Asn Leu Asn Val Ser Leu Cys Ala 
    130                 135                 140                 


Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg Ile Ser Trp 
145                 150                 155                 160 


Asp Ser Glu Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile Ser Tyr Ala 
                165                 170                 175     


Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Thr Tyr Gln Ser 
            180                 185                 190         


Ile Met Tyr Ile Val Leu Val Val Gly Tyr Arg Ile Tyr Asp Val Val 
        195                 200                 205             


Leu Ser Pro Pro His Glu Ile Glu Leu Ser Ala Gly Glu Lys Leu Val 
    210                 215                 220                 


Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Leu Asp Phe Ser 
225                 230                 235                 240 


Trp Gln Phe Pro Ser Ser Lys His Gln His Lys Lys Ile Val Asn Arg 
                245                 250                 255     


Asp Val Lys Ser Leu Pro Gly Thr Val Ala Lys Met Phe Leu Ser Thr 
            260                 265                 270         


Leu Thr Ile Asp Ser Val Thr Lys Ser Asp Gln Gly Glu Tyr Thr Cys 
        275                 280                 285             


Thr Ala Tyr Ser Gly Leu Met Thr Lys Lys Asn Lys Thr Phe Val Arg 
    290                 295                 300                 


Val His Thr Lys Pro Phe Ile Ala Phe Gly Ser Gly Met Lys Ser Leu 
305                 310                 315                 320 


Val Glu Ala Thr Val Gly Ser Gln Val Arg Ile Pro Val Lys Tyr Leu 
                325                 330                 335     


Ser Tyr Pro Ala Pro Asp Ile Lys Trp Tyr Arg Asn Gly Arg Pro Ile 
            340                 345                 350         


Glu Ser Asn Tyr Thr Met Ile Val Gly Asp Glu Leu Thr Ile Met Glu 
        355                 360                 365             


Val Ser Glu Arg Asp Ala Gly Asn Tyr Thr Val Ile Leu Thr Asn Pro 
    370                 375                 380                 


Ile Ser Met Glu Lys Gln Ser His Met Val Ser Leu Val Val Asn Val 
385                 390                 395                 400 


Pro Pro Gln Ile Gly Glu Lys Ala Leu Ile Ser Pro Met Asp Ser Tyr 
                405                 410                 415     


Gln Tyr Gly Thr Met Gln Thr Leu Thr Cys Thr Val Tyr Ala Asn Pro 
            420                 425                 430         


Pro Leu His His Ile Gln Trp Tyr Trp Gln Leu Glu Glu Ala Cys Ser 
        435                 440                 445             


Tyr Arg Pro Ser Gln Thr Asn Pro Tyr Thr Cys Lys Glu Trp Arg His 
    450                 455                 460                 


Val Lys Asp Phe Gln Gly Gly Asn Lys Ile Glu Val Thr Lys Asn Gln 
465                 470                 475                 480 


Tyr Ala Leu Ile Glu Gly Lys Asn Lys Thr Val Ser Thr Leu Val Ile 
                485                 490                 495     


Gln Ala Ala Tyr Val Ser Ala Leu Tyr Lys Cys Glu Ala Ile Asn Lys 
            500                 505                 510         


Ala Gly Arg Gly Glu Arg Val Ile Ser Phe His Val Ile Arg Gly Pro 
        515                 520                 525             


Glu Ile Thr Val Gln Pro Ala Thr Gln Pro Thr Glu Arg Glu Ser Met 
    530                 535                 540                 


Ser Leu Leu Cys Thr Ala Asp Arg Asn Thr Phe Glu Asn Leu Thr Trp 
545                 550                 555                 560 


Tyr Lys Leu Gly Ser Gln Ala Thr Ser Val His Met Gly Glu Ser Leu 
                565                 570                 575     


Thr Pro Val Cys Lys Asn Leu Asp Ala Leu Trp Lys Leu Asn Gly Thr 
            580                 585                 590         


Val Phe Ser Asn Ser Thr Asn Asp Ile Leu Ile Val Ala Phe Gln Asn 
        595                 600                 605             


Ala Ser Leu Gln Asp Gln Gly Asn Tyr Val Cys Ser Ala Gln Asp Lys 
    610                 615                 620                 


Lys Thr Lys Lys Arg His Cys Leu Val Lys Gln Leu Val Ile Leu Glu 
625                 630                 635                 640 


Arg Met Ala Pro Met Ile Thr Gly Asn Leu Glu Asn Gln Thr Thr Thr 
                645                 650                 655     


Ile Gly Glu Thr Ile Glu Val Val Cys Pro Thr Ser Gly Asn Pro Thr 
            660                 665                 670         


Pro Leu Ile Thr Trp Phe Lys Asp Asn Glu Thr Leu Val Glu Asp Ser 
        675                 680                 685             


Gly Ile Val Leu Lys Asp Gly Asn Arg Asn Leu Thr Ile Arg Arg Val 
    690                 695                 700                 


Arg Lys Glu Asp Gly Gly Leu Tyr Thr Cys Gln Ala Cys Asn Val Leu 
705                 710                 715                 720 


Gly Cys Ala Arg Ala Glu Thr Leu Phe Ile Ile Glu Gly Val Gln Glu 
                725                 730                 735     


Lys Thr Asn Leu Glu 
            740     


<210>  29
<211>  756
<212>  PRT
<213>  Human

<400>  29

Tyr Ser Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val 
1               5                   10                  15      


Ile Asp Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro 
            20                  25                  30          


Leu Glu Trp Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp 
        35                  40                  45              


Lys Asp Ser Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp 
    50                  55                  60                  


Ala Arg Pro Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn 
65                  70                  75                  80  


Asp Thr Gly Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile 
                85                  90                  95      


Glu Gly Thr Thr Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu 
            100                 105                 110         


Gln Pro Phe Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp 
        115                 120                 125             


Ala Met Trp Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr 
    130                 135                 140                 


Leu Arg Ser Gln Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val 
145                 150                 155                 160 


Trp Asp Asp Arg Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp 
                165                 170                 175     


Ala Leu Tyr Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu 
            180                 185                 190         


Ser Asn Pro Phe Leu Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile 
        195                 200                 205             


Gln Leu Leu Pro Arg Lys Ser Leu Glu Leu Leu Val Gly Glu Lys Leu 
    210                 215                 220                 


Val Leu Asn Cys Thr Val Trp Ala Glu Phe Asn Ser Gly Val Thr Phe 
225                 230                 235                 240 


Asp Trp Asp Tyr Pro Gly Lys Gln Ala Glu Arg Gly Lys Trp Val Pro 
                245                 250                 255     


Glu Arg Arg Ser Gln Gln Thr His Thr Glu Leu Ser Ser Ile Leu Thr 
            260                 265                 270         


Ile His Asn Val Ser Gln His Asp Leu Gly Ser Tyr Val Cys Lys Ala 
        275                 280                 285             


Asn Asn Gly Ile Gln Arg Phe Arg Glu Ser Thr Glu Val Ile Val His 
    290                 295                 300                 


Glu Asn Pro Phe Ile Ser Val Glu Trp Leu Lys Gly Pro Ile Leu Glu 
305                 310                 315                 320 


Ala Thr Ala Gly Asp Glu Leu Val Lys Leu Pro Val Lys Leu Ala Ala 
                325                 330                 335     


Tyr Pro Pro Pro Glu Phe Gln Trp Tyr Lys Asp Gly Lys Ala Leu Ser 
            340                 345                 350         


Gly Arg His Ser Pro His Ala Leu Val Leu Lys Glu Val Thr Glu Ala 
        355                 360                 365             


Ser Thr Gly Thr Tyr Thr Leu Ala Leu Trp Asn Ser Ala Ala Gly Leu 
    370                 375                 380                 


Arg Arg Asn Ile Ser Leu Glu Leu Val Val Asn Val Pro Pro Gln Ile 
385                 390                 395                 400 


His Glu Lys Glu Ala Ser Ser Pro Ser Ile Tyr Ser Arg His Ser Arg 
                405                 410                 415     


Gln Ala Leu Thr Cys Thr Ala Tyr Gly Val Pro Leu Pro Leu Ser Ile 
            420                 425                 430         


Gln Trp His Trp Arg Pro Trp Thr Pro Cys Lys Met Phe Ala Gln Arg 
        435                 440                 445             


Ser Leu Arg Arg Arg Gln Gln Gln Asp Leu Met Pro Gln Cys Arg Asp 
    450                 455                 460                 


Trp Arg Ala Val Thr Thr Gln Asp Ala Val Asn Pro Ile Glu Ser Leu 
465                 470                 475                 480 


Asp Thr Trp Thr Glu Phe Val Glu Gly Lys Asn Lys Thr Val Ser Lys 
                485                 490                 495     


Leu Val Ile Gln Asn Ala Asn Val Ser Ala Met Tyr Lys Cys Val Val 
            500                 505                 510         


Ser Asn Lys Val Gly Gln Asp Glu Arg Leu Ile Tyr Phe Tyr Val Thr 
        515                 520                 525             


Thr Ile Pro Asp Gly Phe Thr Ile Glu Ser Lys Pro Ser Glu Glu Leu 
    530                 535                 540                 


Leu Glu Gly Gln Pro Val Leu Leu Ser Cys Gln Ala Asp Ser Tyr Lys 
545                 550                 555                 560 


Tyr Glu His Leu Arg Trp Tyr Arg Leu Asn Leu Ser Thr Leu His Asp 
                565                 570                 575     


Ala His Gly Asn Pro Leu Leu Leu Asp Cys Lys Asn Val His Leu Phe 
            580                 585                 590         


Ala Thr Pro Leu Ala Ala Ser Leu Glu Glu Val Ala Pro Gly Ala Arg 
        595                 600                 605             


His Ala Thr Leu Ser Leu Ser Ile Pro Arg Val Ala Pro Glu His Glu 
    610                 615                 620                 


Gly His Tyr Val Cys Glu Val Gln Asp Arg Arg Ser His Asp Lys His 
625                 630                 635                 640 


Cys His Lys Lys Tyr Leu Ser Val Gln Ala Leu Glu Ala Pro Arg Leu 
                645                 650                 655     


Thr Gln Asn Leu Thr Asp Leu Leu Val Asn Val Ser Asp Ser Leu Glu 
            660                 665                 670         


Met Gln Cys Leu Val Ala Gly Ala His Ala Pro Ser Ile Val Trp Tyr 
        675                 680                 685             


Lys Asp Glu Arg Leu Leu Glu Glu Lys Ser Gly Val Asp Leu Ala Asp 
    690                 695                 700                 


Ser Asn Gln Lys Leu Ser Ile Gln Arg Val Arg Glu Glu Asp Ala Gly 
705                 710                 715                 720 


Arg Tyr Leu Cys Ser Val Cys Asn Ala Lys Gly Cys Val Asn Ser Ser 
                725                 730                 735     


Ala Ser Val Ala Val Glu Gly Ser Glu Asp Lys Gly Ser Met Glu Ile 
            740                 745                 750         


Val Ile Leu Val 
        755     


<210>  30
<211>  751
<212>  PRT
<213>  Mouse

<400>  30

Tyr Ser Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Asp Ser Tyr Val 
1               5                   10                  15      


Ile Asp Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro 
            20                  25                  30          


Leu Glu Trp Thr Trp Pro Gly Ala Gln Glu Val Leu Thr Thr Gly Gly 
        35                  40                  45              


Lys Asp Ser Glu Asp Thr Arg Val Val His Asp Cys Glu Gly Thr Glu 
    50                  55                  60                  


Ala Arg Pro Tyr Cys Lys Val Leu Leu Leu Ala Gln Thr His Ala Asn 
65                  70                  75                  80  


Asn Thr Gly Ser Tyr His Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile 
                85                  90                  95      


Glu Gly Thr Thr Ala Ala Ser Thr Tyr Val Phe Val Arg Asp Phe Lys 
            100                 105                 110         


His Pro Phe Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp 
        115                 120                 125             


Ser Met Trp Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Ile Thr 
    130                 135                 140                 


Leu Arg Ser Gln Ser Ser Ala Leu His Pro Asp Gly Gln Glu Val Leu 
145                 150                 155                 160 


Trp Asp Asp Arg Arg Gly Met Arg Val Pro Thr Gln Leu Leu Arg Asp 
                165                 170                 175     


Ala Leu Tyr Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asn Phe Leu 
            180                 185                 190         


Ser Asn Leu Phe Val Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile 
        195                 200                 205             


Gln Leu Tyr Pro Lys Lys Ser Met Glu Leu Leu Val Gly Glu Lys Leu 
    210                 215                 220                 


Val Leu Asn Cys Thr Val Trp Ala Glu Phe Asp Ser Gly Val Thr Phe 
225                 230                 235                 240 


Asp Trp Asp Tyr Pro Gly Lys Gln Ala Glu Arg Ala Lys Trp Val Pro 
                245                 250                 255     


Glu Arg Arg Ser Gln Gln Thr His Thr Glu Leu Ser Ser Ile Leu Thr 
            260                 265                 270         


Ile His Asn Val Ser Gln Asn Asp Leu Gly Pro Tyr Val Cys Glu Ala 
        275                 280                 285             


Asn Asn Gly Ile Gln Arg Phe Arg Glu Ser Thr Glu Val Ile Val His 
    290                 295                 300                 


Glu Lys Pro Phe Ile Ser Val Glu Trp Leu Lys Gly Pro Val Leu Glu 
305                 310                 315                 320 


Ala Thr Ala Gly Asp Glu Leu Val Lys Leu Pro Val Lys Leu Ala Ala 
                325                 330                 335     


Tyr Pro Pro Pro Glu Phe Gln Trp Tyr Lys Asp Arg Lys Ala Val Thr 
            340                 345                 350         


Gly Arg His Asn Pro His Ala Leu Val Leu Lys Glu Val Thr Glu Ala 
        355                 360                 365             


Ser Ala Gly Val Tyr Thr Leu Ala Leu Trp Asn Ser Ala Ala Gly Leu 
    370                 375                 380                 


Arg Gln Asn Ile Ser Leu Glu Leu Val Val Asn Val Pro Pro His Ile 
385                 390                 395                 400 


His Glu Lys Glu Ala Ser Ser Pro Ser Ile Tyr Ser Arg His Ser Arg 
                405                 410                 415     


Gln Thr Leu Thr Cys Thr Ala Tyr Gly Val Pro Gln Pro Leu Ser Val 
            420                 425                 430         


Gln Trp His Trp Arg Pro Trp Thr Pro Cys Lys Thr Phe Ala Gln Arg 
        435                 440                 445             


Ser Leu Arg Arg Arg Gln Gln Arg Asp Gly Met Pro Gln Cys Arg Asp 
    450                 455                 460                 


Trp Lys Glu Val Thr Thr Gln Asp Ala Val Asn Pro Ile Glu Ser Leu 
465                 470                 475                 480 


Asp Ser Trp Thr Glu Phe Val Glu Gly Lys Asn Lys Thr Val Ser Lys 
                485                 490                 495     


Leu Val Ile Gln Asp Ala Asn Val Ser Ala Met Tyr Lys Cys Val Val 
            500                 505                 510         


Val Asn Lys Val Gly Gln Asp Glu Arg Leu Ile Tyr Phe Tyr Val Thr 
        515                 520                 525             


Thr Ile Pro Asp Gly Phe Ser Ile Glu Ser Glu Pro Ser Glu Asp Pro 
    530                 535                 540                 


Leu Glu Gly Gln Ser Val Arg Leu Ser Cys Arg Ala Asp Asn Tyr Thr 
545                 550                 555                 560 


Tyr Glu His Leu Arg Trp Tyr Arg Leu Asn Leu Ser Thr Leu His Asp 
                565                 570                 575     


Ala Gln Gly Asn Pro Leu Leu Leu Asp Cys Lys Asn Val His Leu Phe 
            580                 585                 590         


Ala Thr Pro Leu Glu Ala Asn Leu Glu Glu Ala Glu Pro Gly Ala Arg 
        595                 600                 605             


His Ala Thr Leu Ser Leu Asn Ile Pro Arg Val Ala Pro Glu Asp Glu 
    610                 615                 620                 


Gly Asp Tyr Val Cys Glu Val Gln Asp Arg Arg Ser Gln Asp Lys His 
625                 630                 635                 640 


Cys His Lys Lys Tyr Leu Ser Val Gln Ala Leu Glu Ala Pro Arg Leu 
                645                 650                 655     


Thr Gln Asn Leu Thr Asp Leu Leu Val Asn Val Ser Asp Ser Leu Glu 
            660                 665                 670         


Met Arg Cys Pro Val Ala Gly Ala His Val Pro Ser Ile Val Trp Tyr 
        675                 680                 685             


Lys Asp Glu Arg Leu Leu Glu Lys Glu Ser Gly Ile Asp Leu Ala Asp 
    690                 695                 700                 


Ser Asn Gln Arg Leu Ser Ile Gln Arg Val Arg Glu Glu Asp Ala Gly 
705                 710                 715                 720 


Arg Tyr Leu Cys Ser Val Cys Asn Ala Lys Gly Cys Val Asn Ser Ser 
                725                 730                 735     


Ala Ser Val Ala Val Glu Gly Ser Glu Asp Lys Gly Ser Met Glu 
            740                 745                 750     


<210>  31
<211>  751
<212>  PRT
<213>  Rat

<400>  31

Tyr Ser Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Asp Ser Tyr Val 
1               5                   10                  15      


Ile Asp Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro 
            20                  25                  30          


Leu Glu Trp Thr Trp Arg Gly Ala Gln Glu Val Leu Thr Thr Gly Gly 
        35                  40                  45              


Lys Asp Ser Glu Asp Thr Gln Val Val Gln Asp Cys Glu Gly Thr Glu 
    50                  55                  60                  


Ala Arg Pro Tyr Cys Lys Val Leu Ser Leu Ala Gln Thr His Ala Asn 
65                  70                  75                  80  


Asn Thr Gly Ser Tyr Tyr Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile 
                85                  90                  95      


Glu Gly Thr Thr Ala Ala Ser Thr Tyr Val Phe Val Arg Asp Phe Glu 
            100                 105                 110         


Gln Pro Phe Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp 
        115                 120                 125             


Ser Met Trp Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Ile Thr 
    130                 135                 140                 


Leu Arg Ser Gln Ser Ser Val Leu His Pro Asp Gly Gln Glu Val Leu 
145                 150                 155                 160 


Trp Asp Asp Arg Arg Gly Met Arg Val Pro Thr Leu Leu Leu Arg Asp 
                165                 170                 175     


Ala Leu Tyr Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu 
            180                 185                 190         


Ser Asn Pro Phe Leu Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile 
        195                 200                 205             


Gln Leu Tyr Pro Lys Lys Ser Leu Glu Leu Leu Val Gly Glu Lys Leu 
    210                 215                 220                 


Val Leu Asn Cys Thr Val Trp Ala Glu Phe Asp Ser Gly Val Thr Phe 
225                 230                 235                 240 


Asp Trp Asp Tyr Pro Gly Lys Gln Ala Glu Arg Ala Lys Trp Val Pro 
                245                 250                 255     


Glu Arg Arg Ser Gln Gln Thr His Thr Glu Leu Ser Ser Ile Leu Thr 
            260                 265                 270         


Ile His Asn Val Ser Gln His Asp Leu Gly Pro Tyr Val Cys Glu Ala 
        275                 280                 285             


Asn Asn Gly Ile Gln Gln Phe Arg Glu Ser Thr Glu Val Ile Val His 
    290                 295                 300                 


Glu Lys Pro Phe Ile Ser Val Glu Trp Leu Lys Gly Pro Val Leu Glu 
305                 310                 315                 320 


Ala Thr Ala Gly Asp Glu Met Val Lys Leu Pro Val Lys Leu Ala Ala 
                325                 330                 335     


Tyr Pro Pro Pro Glu Phe Gln Trp Tyr Lys Asp Arg Lys Ala Val Thr 
            340                 345                 350         


Gly Arg His Asn Pro His Ala Leu Val Leu Lys Glu Val Thr Glu Ala 
        355                 360                 365             


Ser Ala Gly Val Tyr Thr Leu Ala Leu Trp Asn Ser Ala Ala Gly Leu 
    370                 375                 380                 


Arg Gln Asn Ile Ser Leu Glu Leu Val Val Asn Val Pro Pro His Ile 
385                 390                 395                 400 


His Glu Lys Glu Ala Ser Ser Pro Ser Ile Tyr Ser Arg His Ser Arg 
                405                 410                 415     


Gln Thr Leu Thr Cys Thr Thr Tyr Gly Val Pro Gln Pro Leu Ser Val 
            420                 425                 430         


Gln Trp His Trp Arg Pro Trp Thr Pro Cys Lys Thr Phe Ala Gln Arg 
        435                 440                 445             


Ser Leu Arg Arg Arg Gln Pro Arg Asp Gly Met Pro Gln Cys Arg Asp 
    450                 455                 460                 


Trp Lys Glu Val Thr Thr Gln Asp Ala Val Asn Pro Ile Glu Ser Leu 
465                 470                 475                 480 


Asp Thr Trp Thr Glu Ser Val Glu Gly Lys Asn Lys Thr Val Ser Lys 
                485                 490                 495     


Leu Val Ile Gln Asp Ala Asn Val Ser Ala Met Tyr Lys Cys Val Val 
            500                 505                 510         


Phe Asn Lys Val Gly Gln Asp Glu Arg Leu Ile Tyr Phe Tyr Val Thr 
        515                 520                 525             


Thr Ile Pro Asp Gly Phe Ser Ile Glu Ser Glu Pro Ser Glu Asp Pro 
    530                 535                 540                 


Leu Glu Gly Gln Ser Val Arg Leu Ser Cys Arg Ala Asp Asn Tyr Thr 
545                 550                 555                 560 


Tyr Glu His Leu Arg Trp Tyr Arg Leu Asn Leu Ser Thr Leu His Asp 
                565                 570                 575     


Ala Gln Gly Asn Pro Leu Leu Leu Asp Cys Lys Asn Val His Leu Phe 
            580                 585                 590         


Ala Thr Pro Leu Glu Ala Asn Leu Glu Glu Ala Glu Pro Gly Ala Arg 
        595                 600                 605             


His Ala Thr Leu Ser Leu Asn Ile Pro Arg Val Ala Pro Glu Asp Glu 
    610                 615                 620                 


Gly Asp Tyr Val Cys Glu Val Gln Asp Arg Arg Ser Gln Asp Lys His 
625                 630                 635                 640 


Cys His Lys Lys Tyr Leu Ser Val Gln Ala Leu Glu Ala Pro Arg Leu 
                645                 650                 655     


Thr Gln Asn Leu Thr Asp Leu Leu Val Asn Val Arg Thr Ser Leu Glu 
            660                 665                 670         


Met Arg Cys Pro Val Ala Gly Ala His Val Pro Ser Ile Val Trp Tyr 
        675                 680                 685             


Lys Asp Glu Arg Leu Leu Glu Lys Glu Ser Gly Ile Asp Leu Ala Asp 
    690                 695                 700                 


Ser Asn Gln Arg Leu Ser Ile Gln Arg Val Arg Glu Glu Asp Ala Gly 
705                 710                 715                 720 


Arg Tyr Leu Cys Ser Val Cys Asn Ala Lys Gly Cys Val Asn Ser Ser 
                725                 730                 735     


Ala Ser Val Ala Val Glu Gly Ser Glu Asp Lys Gly Ser Met Glu 
            740                 745                 750     


<210>  32
<211>  220
<212>  PRT
<213>  Human

<400>  32

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  33
<211>  223
<212>  PRT
<213>  Human

<400>  33

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  34
<211>  223
<212>  PRT
<213>  Human

<400>  34

Thr Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  35
<211>  4474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pITR.CBA.Bevacizumab

<400>  35
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgacatt gattattgac tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggac tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catgggtcga ggtgagcccc      540

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt      600

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggcgcg cgccaggcgg      660

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      720

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      780

aaagcgaagc gcgcggcggg cgggagtcgc tgcgttgcct tcgccccgtg ccccgctccg      840

cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg      900

gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac ggctcgtttc      960

ttttctgtgg ctgcgtgaaa gccttaaagg gctccgggag ggccctttgt gcggggggga     1020

gcggctcggg gggtgcgtgc gtgtgtgtgt gcgtggggag cgccgcgtgc ggcccgcgct     1080

gcccggcggc tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcgtgtgcgc     1140

gaggggagcg cggccggggg cggtgccccg cggtgcgggg gggctgcgag gggaacaaag     1200

gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg gcggtcgggc     1260

tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc ttcgggtgcg     1320

gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg     1380

ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga ggggcgcggc     1440

ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg ccttttatgg     1500

taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga gccgaaatct     1560

gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg cgccggcagg     1620

aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct tctccctctc     1680

cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg cagggcgggg     1740

ttcggcttct ggcgtgtgac cggcggctct agagcctctg ctaaccatgt tcatgccttc     1800

ttctttttcc tacagctcct gggcaacgtg ctggttattg tgaccggtgc caccatgtac     1860

cggatgcagc tgctgagctg tatcgccctg tctctggccc tggtcaccaa ttctgaggtg     1920

cagctggtgg aatctggcgg cggacttgtt caacctggcg gctctctgag actgagctgt     1980

gccgcttctg gctacacctt caccaactac ggcatgaact gggtccgaca ggcccctggc     2040

aaaggccttg aatgggtcgg atggatcaac acctacaccg gcgagccaac atacgccgcc     2100

gacttcaagc ggagattcac cttcagcctg gacaccagca agagcaccgc ctacctgcag     2160

atgaacagcc tgagagccga ggacaccgcc gtgtactact gcgccaagta tccccactac     2220

tacggcagca gccactggta ctttgacgtg tggggacagg gcacactggt cacagtgtct     2280

agcgcctcta caaagggccc cagcgttttc ccactggctc ctagcagcaa gtctaccagc     2340

ggaggaacag ccgctctggg ctgtctggtc aaggactact ttcccgagcc tgtgaccgtg     2400

tcctggaatt ctggcgctct gacaagcggc gtgcacacct ttccagctgt gctgcaaagc     2460

agcggcctgt actctctgag cagcgtcgtg acagtgccaa gcagctctct gggcacccag     2520

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa     2580

cccaagagct gcgacaagac ccacacctgt cctccatgtc ctgctccaga actgctcggc     2640

ggaccttccg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc     2700

cctgaagtga cctgcgtggt ggtggatgtg tcccacgagg atcccgaagt gaagttcaat     2760

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     2820

aacagcacct acagagtggt gtccgtgctg accgtgctgc accaggattg gctgaacggc     2880

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg ctcctatcga gaaaaccatc     2940

agcaaggcca agggccagcc tagggaaccc caggtttaca cactgcctcc aagccgggaa     3000

gagatgacca agaaccaggt gtccctgacc tgcctcgtga agggcttcta cccttccgat     3060

atcgccgtgg aatgggagag caatggccag ccagagaaca actacaagac aacccctcct     3120

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgacagtgga caagtccaga     3180

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     3240

acccagaagt ctctgagcct gtctcctggc aagcggaaga gaagaggctc tggcgaaggc     3300

agaggcagcc tgcttacatg tggcgacgtg gaagagaacc ccggacctat gtatagaatg     3360

cagctcctgt cctgcattgc cctgagcctg gctctcgtga ccaacagcga catccagatg     3420

acacagagcc ccagcagcct gtctgcctct gtgggagaca gagtgaccat cacctgtagc     3480

gccagccagg acatctccaa ctacctgaac tggtatcagc aaaagcccgg caaggcccct     3540

aaggtgctga tctacttcac aagcagcctg cactccggcg tgcccagcag attttctggc     3600

tctggcagcg gcaccgactt caccctgacc atatctagcc tgcagcctga ggacttcgcc     3660

acctactact gccagcagta cagcaccgtg ccttggacat ttggccaggg cacaaaggtg     3720

gaaatcaagc ggactgtggc cgctcctagc gtgttcatct ttccacctag cgacgagcag     3780

ctgaagtctg gcacagcctc tgtcgtgtgc ctgctgaaca acttctaccc cagagaagcc     3840

aaggtgcagt ggaaagtgga caatgccctg cagagcggca acagccaaga gagcgtgaca     3900

gagcaggact ccaaggatag cacctatagc ctgagcagca ccctgacact gagcaaggcc     3960

gactacgaga agcacaaagt gtacgcctgc gaagtgaccc accagggcct ttctagccct     4020

gtgaccaaga gcttcaaccg gggcgaatgt taagagctcg ctgatcagcc tcgactgtgc     4080

cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag     4140

gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta     4200

ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag     4260

acaatagcag gcatgctggg gatgcggtgg gctctatgga agcttgaatt cagctgacgt     4320

gcctcggacc gctaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     4380

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     4440

tcagtgagcg agcgagcgcg cagctgcctg cagg                                 4474


<210>  36
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ITR sequence

<400>  36
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgt                                             144


<210>  37
<211>  1671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CBA sequence

<400>  37
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      660

agtcgctgcg ttgccttcgc cccgtgcccc gctccgcgcc gcctcgcgcc gcccgccccg      720

gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg      780

ctgtaattag cgcttggttt aatgacggct cgtttctttt ctgtggctgc gtgaaagcct      840

taaagggctc cgggagggcc ctttgtgcgg gggggagcgg ctcggggggt gcgtgcgtgt      900

gtgtgtgcgt ggggagcgcc gcgtgcggcc cgcgctgccc ggcggctgtg agcgctgcgg      960

gcgcggcgcg gggctttgtg cgctccgcgt gtgcgcgagg ggagcgcggc cgggggcggt     1020

gccccgcggt gcgggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg     1080

gggggtgagc agggggtgtg ggcgcggcgg tcgggctgta acccccccct gcacccccct     1140

ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtgcggg gcgtggcgcg     1200

gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg     1260

cctcgggccg gggagggctc gggggagggg cgcggcggcc cccggagcgc cggcggctgt     1320

cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat cgtgcgagag ggcgcaggga     1380

cttcctttgt cccaaatctg tgcggagccg aaatctggga ggcgccgccg caccccctct     1440

agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc ctcggggctg tccgcggggg     1560

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1620

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca g              1671


<210>  38
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  38
ctcctgggca acgtgctggt tattgtgacc ggtgccacc                              39


<210>  39
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 secretion signal sequence

<400>  39
atgtaccgga tgcagctgct gagctgtatc gccctgtctc tggccctggt caccaattct       60


<210>  40
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding heavy chain of bevacizumab

<400>  40
gaggtgcagc tggtggaatc tggcggcgga cttgttcaac ctggcggctc tctgagactg       60

agctgtgccg cttctggcta caccttcacc aactacggca tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtcggatgg atcaacacct acaccggcga gccaacatac      180

gccgccgact tcaagcggag attcaccttc agcctggaca ccagcaagag caccgcctac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcgc caagtatccc      300

cactactacg gcagcagcca ctggtacttt gacgtgtggg gacagggcac actggtcaca      360

gtgtctagcg cctctacaaa gggccccagc gttttcccac tggctcctag cagcaagtct      420

accagcggag gaacagccgc tctgggctgt ctggtcaagg actactttcc cgagcctgtg      480

accgtgtcct ggaattctgg cgctctgaca agcggcgtgc acacctttcc agctgtgctg      540

caaagcagcg gcctgtactc tctgagcagc gtcgtgacag tgccaagcag ctctctgggc      600

acccagacct acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcctc catgtcctgc tccagaactg      720

ctcggcggac cttccgtgtt cctgtttcct ccaaagccta aggacaccct gatgatcagc      780

agaacccctg aagtgacctg cgtggtggtg gatgtgtccc acgaggatcc cgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctacag agtggtgtcc gtgctgaccg tgctgcacca ggattggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc tatcgagaaa     1020

accatcagca aggccaaggg ccagcctagg gaaccccagg tttacacact gcctccaagc     1080

cgggaagaga tgaccaagaa ccaggtgtcc ctgacctgcc tcgtgaaggg cttctaccct     1140

tccgatatcg ccgtggaatg ggagagcaat ggccagccag agaacaacta caagacaacc     1200

cctcctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac agtggacaag     1260

tccagatggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtctct gagcctgtct cctggcaag                            1359


<210>  41
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  41
cggaagagaa ga                                                           12


<210>  42
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A sequence

<400>  42
ggctctggcg aaggcagagg cagcctgctt acatgtggcg acgtggaaga gaaccccgga       60

cct                                                                     63


<210>  43
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 secretion signal sequence

<400>  43
atgtatagaa tgcagctcct gtcctgcatt gccctgagcc tggctctcgt gaccaacagc       60


<210>  44
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding light chain of bevacizumab

<400>  44
gacatccaga tgacacagag ccccagcagc ctgtctgcct ctgtgggaga cagagtgacc       60

atcacctgta gcgccagcca ggacatctcc aactacctga actggtatca gcaaaagccc      120

ggcaaggccc ctaaggtgct gatctacttc acaagcagcc tgcactccgg cgtgcccagc      180

agattttctg gctctggcag cggcaccgac ttcaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccttggac atttggccag      300

ggcacaaagg tggaaatcaa gcggactgtg gccgctccta gcgtgttcat ctttccacct      360

agcgacgagc agctgaagtc tggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

cccagagaag ccaaggtgca gtggaaagtg gacaatgccc tgcagagcgg caacagccaa      480

gagagcgtga cagagcagga ctccaaggat agcacctata gcctgagcag caccctgaca      540

ctgagcaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctttctagcc ctgtgaccaa gagcttcaac cggggcgaat gttaa                      645


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  45
gagctcgctg atcagcctcg a                                                 21


<210>  46
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bovine growth hormone polyA tail sequence

<400>  46
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  47
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  47
aagcttgaat tcagctgacg tgcctcggac cgct                                   34


<210>  48
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ITR

<400>  48
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 signal sequence

<400>  49

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  50
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A sequence

<400>  50

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  51
<211>  3814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pITR.CBA.lucentis

<400>  51
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgacatt gattattgac tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggac tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catgggtcga ggtgagcccc      540

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt      600

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggcgcg cgccaggcgg      660

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      720

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      780

aaagcgaagc gcgcggcggg cgggagtcgc tgcgttgcct tcgccccgtg ccccgctccg      840

cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg      900

gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac ggctcgtttc      960

ttttctgtgg ctgcgtgaaa gccttaaagg gctccgggag ggccctttgt gcggggggga     1020

gcggctcggg gggtgcgtgc gtgtgtgtgt gcgtggggag cgccgcgtgc ggcccgcgct     1080

gcccggcggc tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcgtgtgcgc     1140

gaggggagcg cggccggggg cggtgccccg cggtgcgggg gggctgcgag gggaacaaag     1200

gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg gcggtcgggc     1260

tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc ttcgggtgcg     1320

gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg     1380

ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga ggggcgcggc     1440

ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg ccttttatgg     1500

taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga gccgaaatct     1560

gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg cgccggcagg     1620

aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct tctccctctc     1680

cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg cagggcgggg     1740

ttcggcttct ggcgtgtgac cggcggctct agagcctctg ctaaccatgt tcatgccttc     1800

ttctttttcc tacagctcct gggcaacgtg ctggttattg tgaccggtgc caccatgtac     1860

cggatgcagc tgctgagctg tatcgccctg tctctggccc tggtcaccaa ttctgaggtg     1920

cagctggtgg aatctggcgg cggacttgtt caacctggcg gctctctgag actgagctgt     1980

gccgcttctg gctacgactt cacccactac ggcatgaact gggtccgaca ggcccctggc     2040

aaaggccttg aatgggtcgg atggatcaac acctacaccg gcgagccaac atacgccgcc     2100

gacttcaagc ggagattcac cttcagcctg gacaccagca agagcaccgc ctacctgcag     2160

atgaacagcc tgagagccga ggacaccgcc gtgtactact gcgccaagta tccctactac     2220

tacggcacca gccactggta ctttgacgtg tggggacagg gcacactggt cacagtgtct     2280

agcgcctcta caaagggccc cagcgttttc ccactggctc ctagcagcaa gtctaccagc     2340

ggaggaacag ccgctctggg ctgtctggtc aaggactact ttcccgagcc tgtgaccgtg     2400

tcctggaatt ctggcgctct gacaagcggc gtgcacacct ttccagctgt gctgcaaagc     2460

agcggcctgt actctctgag cagcgtcgtg acagtgccaa gcagctctct gggcacccag     2520

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa     2580

cccaagagct gcgacaagac ccacaccggc aagcggaaga gaagaggctc tggcgaaggc     2640

agaggcagcc tgcttacatg tggcgacgtg gaagagaacc ccggacctat gtatagaatg     2700

cagctcctgt cctgcattgc cctgagcctg gctctcgtga ccaacagcga catccagctg     2760

acacagagcc ccagcagcct gtctgcctct gtgggagaca gagtgaccat cacctgtagc     2820

gccagccagg acatctccaa ctacctgaac tggtatcagc aaaagcccgg caaggcccct     2880

aaggtgctga tctacttcac aagcagcctg cactccggcg tgcccagcag attttctggc     2940

tctggcagcg gcaccgactt caccctgacc atatctagcc tgcagcctga ggacttcgcc     3000

acctactact gccagcagta cagcaccgtg ccttggacat ttggccaggg cacaaaggtg     3060

gaaatcaagc ggactgtggc cgctcctagc gtgttcatct ttccacctag cgacgagcag     3120

ctgaagtctg gcacagcctc tgtcgtgtgc ctgctgaaca acttctaccc cagagaagcc     3180

aaggtgcagt ggaaagtgga caatgccctg cagagcggca acagccaaga gagcgtgaca     3240

gagcaggact ccaaggatag cacctatagc ctgagcagca ccctgacact gagcaaggcc     3300

gactacgaga agcacaaagt gtacgcctgc gaagtgaccc accagggcct ttctagccct     3360

gtgaccaaga gcttcaaccg gggcgaatgt taagagctcg ctgatcagcc tcgactgtgc     3420

cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag     3480

gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta     3540

ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag     3600

acaatagcag gcatgctggg gatgcggtgg gctctatgga agcttgaatt cagctgacgt     3660

gcctcggacc gctaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     3720

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     3780

tcagtgagcg agcgagcgcg cagctgcctg cagg                                 3814


<210>  52
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding ranibizumab heavy chain

<400>  52
gaggtgcagc tggtggaatc tggcggcgga cttgttcaac ctggcggctc tctgagactg       60

agctgtgccg cttctggcta cgacttcacc cactacggca tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtcggatgg atcaacacct acaccggcga gccaacatac      180

gccgccgact tcaagcggag attcaccttc agcctggaca ccagcaagag caccgcctac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcgc caagtatccc      300

tactactacg gcaccagcca ctggtacttt gacgtgtggg gacagggcac actggtcaca      360

gtgtctagcg cctctacaaa gggccccagc gttttcccac tggctcctag cagcaagtct      420

accagcggag gaacagccgc tctgggctgt ctggtcaagg actactttcc cgagcctgtg      480

accgtgtcct ggaattctgg cgctctgaca agcggcgtgc acacctttcc agctgtgctg      540

caaagcagcg gcctgtactc tctgagcagc gtcgtgacag tgccaagcag ctctctgggc      600

acccagacct acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac accggcaag                             699


<210>  53
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding ranibizumab light chain

<400>  53
gacatccagc tgacacagag ccccagcagc ctgtctgcct ctgtgggaga cagagtgacc       60

atcacctgta gcgccagcca ggacatctcc aactacctga actggtatca gcaaaagccc      120

ggcaaggccc ctaaggtgct gatctacttc acaagcagcc tgcactccgg cgtgcccagc      180

agattttctg gctctggcag cggcaccgac ttcaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccttggac atttggccag      300

ggcacaaagg tggaaatcaa gcggactgtg gccgctccta gcgtgttcat ctttccacct      360

agcgacgagc agctgaagtc tggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

cccagagaag ccaaggtgca gtggaaagtg gacaatgccc tgcagagcgg caacagccaa      480

gagagcgtga cagagcagga ctccaaggat agcacctata gcctgagcag caccctgaca      540

ctgagcaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctttctagcc ctgtgaccaa gagcttcaac cggggcgaat gttaa                      645


<210>  54
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab Heavy Chain

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Lys 
225                 230             


<210>  55
<211>  4573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pITR.CBA.Lucentis.tGFP

<400>  55
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgacatt gattattgac tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggac tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catgggtcga ggtgagcccc      540

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt      600

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggcgcg cgccaggcgg      660

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      720

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      780

aaagcgaagc gcgcggcggg cgggagtcgc tgcgttgcct tcgccccgtg ccccgctccg      840

cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg      900

gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac ggctcgtttc      960

ttttctgtgg ctgcgtgaaa gccttaaagg gctccgggag ggccctttgt gcggggggga     1020

gcggctcggg gggtgcgtgc gtgtgtgtgt gcgtggggag cgccgcgtgc ggcccgcgct     1080

gcccggcggc tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcgtgtgcgc     1140

gaggggagcg cggccggggg cggtgccccg cggtgcgggg gggctgcgag gggaacaaag     1200

gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg gcggtcgggc     1260

tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc ttcgggtgcg     1320

gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg     1380

ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga ggggcgcggc     1440

ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg ccttttatgg     1500

taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga gccgaaatct     1560

gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg cgccggcagg     1620

aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct tctccctctc     1680

cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg cagggcgggg     1740

ttcggcttct ggcgtgtgac cggcggctct agagcctctg ctaaccatgt tcatgccttc     1800

ttctttttcc tacagctcct gggcaacgtg ctggttattg tgaccggtgc caccatgtac     1860

cggatgcagc tgctgagctg tatcgccctg tctctggccc tggtcaccaa ttctgaggtg     1920

cagctggtgg aatctggcgg cggacttgtt caacctggcg gctctctgag actgagctgt     1980

gccgcttctg gctacgactt cacccactac ggcatgaact gggtccgaca ggcccctggc     2040

aaaggccttg aatgggtcgg atggatcaac acctacaccg gcgagccaac atacgccgcc     2100

gacttcaagc ggagattcac cttcagcctg gacaccagca agagcaccgc ctacctgcag     2160

atgaacagcc tgagagccga ggacaccgcc gtgtactact gcgccaagta tccctactac     2220

tacggcacca gccactggta ctttgacgtg tggggacagg gcacactggt cacagtgtct     2280

agcgcctcta caaagggccc cagcgttttc ccactggctc ctagcagcaa gtctaccagc     2340

ggaggaacag ccgctctggg ctgtctggtc aaggactact ttcccgagcc tgtgaccgtg     2400

tcctggaatt ctggcgctct gacaagcggc gtgcacacct ttccagctgt gctgcaaagc     2460

agcggcctgt actctctgag cagcgtcgtg acagtgccaa gcagctctct gggcacccag     2520

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa     2580

cccaagagct gcgacaagac ccacaccggc aagcggaaga gaagaggctc tggcgaaggc     2640

agaggcagcc tgcttacatg tggcgacgtg gaagagaacc ccggacctat gtatagaatg     2700

cagctcctgt cctgcattgc cctgagcctg gctctcgtga ccaacagcga catccagctg     2760

acacagagcc ccagcagcct gtctgcctct gtgggagaca gagtgaccat cacctgtagc     2820

gccagccagg acatctccaa ctacctgaac tggtatcagc aaaagcccgg caaggcccct     2880

aaggtgctga tctacttcac aagcagcctg cactccggcg tgcccagcag attttctggc     2940

tctggcagcg gcaccgactt caccctgacc atatctagcc tgcagcctga ggacttcgcc     3000

acctactact gccagcagta cagcaccgtg ccttggacat ttggccaggg cacaaaggtg     3060

gaaatcaagc ggactgtggc cgctcctagc gtgttcatct ttccacctag cgacgagcag     3120

ctgaagtctg gcacagcctc tgtcgtgtgc ctgctgaaca acttctaccc cagagaagcc     3180

aaggtgcagt ggaaagtgga caatgccctg cagagcggca acagccaaga gagcgtgaca     3240

gagcaggact ccaaggatag cacctatagc ctgagcagca ccctgacact gagcaaggcc     3300

gactacgaga agcacaaagt gtacgcctgc gaagtgaccc accagggcct ttctagccct     3360

gtgaccaaga gcttcaaccg gggcgaatgt ggctccggag agggcagagg aagtctgcta     3420

acatgcggtg acgtcgagga gaatcctggc ccaatggaga gcgacgagag cggcctgccc     3480

gccatggaga tcgagtgccg catcaccggc accctgaacg gcgtggagtt cgagctggtg     3540

ggcggcggag agggcacccc cgagcagggc cgcatgacca acaagatgaa gagcaccaaa     3600

ggcgccctga ccttcagccc ctacctgctg agccacgtga tgggctacgg cttctaccac     3660

ttcggcacct accccagcgg ctacgagaac cccttcctgc acgccatcaa caacggcggc     3720

tacaccaaca cccgcatcga gaagtacgag gacggcggcg tgctgcacgt gagcttcagc     3780

taccgctacg aggccggccg cgtgatcggc gacttcaagg tgatgggcac cggcttcccc     3840

gaggacagcg tgatcttcac cgacaagatc atccgcagca acgccaccgt ggagcacctg     3900

caccccatgg gcgataacga tctggatggc agcttcaccc gcaccttcag cctgcgcgac     3960

ggcggctact acagctccgt ggtggacagc cacatgcact tcaagagcgc catccacccc     4020

agcatcctgc agaacggggg ccccatgttc gccttccgcc gcgtggagga ggatcacagc     4080

aacaccgagc tgggcatcgt ggagtaccag cacgccttca agaccccgga tgcagatgcc     4140

ggtgaagaat aagagctcgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg     4200

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     4260

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     4320

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg     4380

atgcggtggg ctctatggaa gcttgaattc agctgacgtg cctcggaccg ctaggaaccc     4440

ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga     4500

ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc     4560

agctgcctgc agg                                                        4573


<210>  56
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding ranibizumab light chain

<400>  56
gacatccagc tgacacagag ccccagcagc ctgtctgcct ctgtgggaga cagagtgacc       60

atcacctgta gcgccagcca ggacatctcc aactacctga actggtatca gcaaaagccc      120

ggcaaggccc ctaaggtgct gatctacttc acaagcagcc tgcactccgg cgtgcccagc      180

agattttctg gctctggcag cggcaccgac ttcaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccttggac atttggccag      300

ggcacaaagg tggaaatcaa gcggactgtg gccgctccta gcgtgttcat ctttccacct      360

agcgacgagc agctgaagtc tggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

cccagagaag ccaaggtgca gtggaaagtg gacaatgccc tgcagagcgg caacagccaa      480

gagagcgtga cagagcagga ctccaaggat agcacctata gcctgagcag caccctgaca      540

ctgagcaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac ccaccagggc      600

ctttctagcc ctgtgaccaa gagcttcaac cggggcgaat gt                         642


<210>  57
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  57
ggctccggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctggc       60

cca                                                                     63


<210>  58
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding Turbo GFP

<400>  58
atggagagcg acgagagcgg cctgcccgcc atggagatcg agtgccgcat caccggcacc       60

ctgaacggcg tggagttcga gctggtgggc ggcggagagg gcacccccga gcagggccgc      120

atgaccaaca agatgaagag caccaaaggc gccctgacct tcagccccta cctgctgagc      180

cacgtgatgg gctacggctt ctaccacttc ggcacctacc ccagcggcta cgagaacccc      240

ttcctgcacg ccatcaacaa cggcggctac accaacaccc gcatcgagaa gtacgaggac      300

ggcggcgtgc tgcacgtgag cttcagctac cgctacgagg ccggccgcgt gatcggcgac      360

ttcaaggtga tgggcaccgg cttccccgag gacagcgtga tcttcaccga caagatcatc      420

cgcagcaacg ccaccgtgga gcacctgcac cccatgggcg ataacgatct ggatggcagc      480

ttcacccgca ccttcagcct gcgcgacggc ggctactaca gctccgtggt ggacagccac      540

atgcacttca agagcgccat ccaccccagc atcctgcaga acgggggccc catgttcgcc      600

ttccgccgcg tggaggagga tcacagcaac accgagctgg gcatcgtgga gtaccagcac      660

gccttcaaga ccccggatgc agatgccggt gaagaataa                             699


<210>  59
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Turbo GFP

<400>  59

Met Glu Ser Asp Glu Ser Gly Leu Pro Ala Met Glu Ile Glu Cys Arg 
1               5                   10                  15      


Ile Thr Gly Thr Leu Asn Gly Val Glu Phe Glu Leu Val Gly Gly Gly 
            20                  25                  30          


Glu Gly Thr Pro Glu Gln Gly Arg Met Thr Asn Lys Met Lys Ser Thr 
        35                  40                  45              


Lys Gly Ala Leu Thr Phe Ser Pro Tyr Leu Leu Ser His Val Met Gly 
    50                  55                  60                  


Tyr Gly Phe Tyr His Phe Gly Thr Tyr Pro Ser Gly Tyr Glu Asn Pro 
65                  70                  75                  80  


Phe Leu His Ala Ile Asn Asn Gly Gly Tyr Thr Asn Thr Arg Ile Glu 
                85                  90                  95      


Lys Tyr Glu Asp Gly Gly Val Leu His Val Ser Phe Ser Tyr Arg Tyr 
            100                 105                 110         


Glu Ala Gly Arg Val Ile Gly Asp Phe Lys Val Met Gly Thr Gly Phe 
        115                 120                 125             


Pro Glu Asp Ser Val Ile Phe Thr Asp Lys Ile Ile Arg Ser Asn Ala 
    130                 135                 140                 


Thr Val Glu His Leu His Pro Met Gly Asp Asn Asp Leu Asp Gly Ser 
145                 150                 155                 160 


Phe Thr Arg Thr Phe Ser Leu Arg Asp Gly Gly Tyr Tyr Ser Ser Val 
                165                 170                 175     


Val Asp Ser His Met His Phe Lys Ser Ala Ile His Pro Ser Ile Leu 
            180                 185                 190         


Gln Asn Gly Gly Pro Met Phe Ala Phe Arg Arg Val Glu Glu Asp His 
        195                 200                 205             


Ser Asn Thr Glu Leu Gly Ile Val Glu Tyr Gln His Ala Phe Lys Thr 
    210                 215                 220                 


Pro Asp Ala Asp Ala Gly Glu Glu 
225                 230         


<210>  60
<211>  3631
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pITR.CBA.Eylea

<400>  60
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgacatt gattattgac tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggac tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catgggtcga ggtgagcccc      540

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt      600

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggcgcg cgccaggcgg      660

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      720

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      780

aaagcgaagc gcgcggcggg cgggagtcgc tgcgttgcct tcgccccgtg ccccgctccg      840

cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg      900

gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttaatgac ggctcgtttc      960

ttttctgtgg ctgcgtgaaa gccttaaagg gctccgggag ggccctttgt gcggggggga     1020

gcggctcggg gggtgcgtgc gtgtgtgtgt gcgtggggag cgccgcgtgc ggcccgcgct     1080

gcccggcggc tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcgtgtgcgc     1140

gaggggagcg cggccggggg cggtgccccg cggtgcgggg gggctgcgag gggaacaaag     1200

gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg gcggtcgggc     1260

tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc ttcgggtgcg     1320

gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg     1380

ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga ggggcgcggc     1440

ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg ccttttatgg     1500

taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga gccgaaatct     1560

gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg cgccggcagg     1620

aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct tctccctctc     1680

cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg cagggcgggg     1740

ttcggcttct ggcgtgtgac cggcggctct agagcctctg ctaaccatgt tcatgccttc     1800

ttctttttcc tacagctcct gggcaacgtg ctggttattg tgaccggtgc caccatgtac     1860

cggatgcagc tgctgagctg tatcgccctg tctctggccc tggtcaccaa ttctagcgat     1920

accggcagac ccttcgtgga aatgtacagc gagatccccg agatcatcca catgaccgag     1980

ggcagagagc tggtcatccc ctgcagagtg acaagcccca acatcaccgt gactctgaag     2040

aagttccctc tggacacact gatccccgac ggcaagagaa tcatctggga cagccggaag     2100

ggcttcatca tcagcaacgc cacctacaaa gagatcggcc tgctgacctg tgaagccacc     2160

gtgaatggcc acctgtacaa gaccaactac ctgacacaca gacagaccaa caccatcatc     2220

gacgtggtgc tgagccctag ccacggcatt gaactgtctg tgggcgagaa gctggtgctg     2280

aactgtaccg ccagaaccga gctgaacgtg ggcatcgact tcaactggga gtaccccagc     2340

agcaagcacc agcacaagaa actggtcaac cgggacctga aaacccagag cggcagcgag     2400

atgaagaaat tcctgagcac cctgaccatc gacggcgtga ccagatctga ccagggcctg     2460

tacacatgtg ccgccagctc tggcctgatg accaagaaaa acagcacctt cgtgcgggtg     2520

cacgagaagg acaagaccca cacctgtcct ccatgtcctg ctccagaact gctcggcgga     2580

ccttccgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct     2640

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggatc ccgaagtgaa gttcaattgg     2700

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaat     2760

agcacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa     2820

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctatcgagaa aaccatctcc     2880

aaggccaagg gccagcctag ggaaccccag gtttacacac tgcctccaag cagggacgag     2940

ctgacaaaga accaggtgtc cctgacctgc ctggtcaagg gcttctaccc ttccgatatc     3000

gccgtggaat gggagagcaa tggccagcct gagaacaact acaagacaac ccctcctgtg     3060

ctggacagcg acggctcatt cttcctgtac agcaagctga cagtggacaa gagcagatgg     3120

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     3180

cagaagtccc tgagcctgtc tcctggataa gagctcgctg atcagcctcg actgtgcctt     3240

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     3300

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     3360

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     3420

atagcaggca tgctggggat gcggtgggct ctatggaagc ttgaattcag ctgacgtgcc     3480

tcggaccgct aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     3540

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     3600

gtgagcgagc gagcgcgcag ctgcctgcag g                                    3631


<210>  61
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding aflibercept

<400>  61
agcgataccg gcagaccctt cgtggaaatg tacagcgaga tccccgagat catccacatg       60

accgagggca gagagctggt catcccctgc agagtgacaa gccccaacat caccgtgact      120

ctgaagaagt tccctctgga cacactgatc cccgacggca agagaatcat ctgggacagc      180

cggaagggct tcatcatcag caacgccacc tacaaagaga tcggcctgct gacctgtgaa      240

gccaccgtga atggccacct gtacaagacc aactacctga cacacagaca gaccaacacc      300

atcatcgacg tggtgctgag ccctagccac ggcattgaac tgtctgtggg cgagaagctg      360

gtgctgaact gtaccgccag aaccgagctg aacgtgggca tcgacttcaa ctgggagtac      420

cccagcagca agcaccagca caagaaactg gtcaaccggg acctgaaaac ccagagcggc      480

agcgagatga agaaattcct gagcaccctg accatcgacg gcgtgaccag atctgaccag      540

ggcctgtaca catgtgccgc cagctctggc ctgatgacca agaaaaacag caccttcgtg      600

cgggtgcacg agaaggacaa gacccacacc tgtcctccat gtcctgctcc agaactgctc      660

ggcggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      720

acccctgaag tgacctgcgt ggtggtggat gtgtcccacg aggatcccga agtgaagttc      780

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      840

tacaatagca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac      900

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc      960

atctccaagg ccaagggcca gcctagggaa ccccaggttt acacactgcc tccaagcagg     1020

gacgagctga caaagaacca ggtgtccctg acctgcctgg tcaagggctt ctacccttcc     1080

gatatcgccg tggaatggga gagcaatggc cagcctgaga acaactacaa gacaacccct     1140

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgacagt ggacaagagc     1200

agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1260

tacacccaga agtccctgag cctgtctcct ggataa                               1296


