                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       GROMADA, Jesper
       STEVIS, Panayiotis
       ALTAREJOS, Judith
 
<120>  BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND LEPTIN RECEPTOR 
       AND/OR GP130, AND METHODS OF USE THEREOF

<130>  10397WO01

<140>  TBD
<141>  2018-12-17

<150>  62/607,137
<151>  2017-12-18

<150>  62/635,406
<151>  2018-02-26

<160>  198   

<170>  PatentIn version 3.5

<210>  1
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
caggtgcagc tggtggagtc cgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtacag cgtctggatt caccttcagt agttatgcca tgtactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgtcagtt atatactatg atggaagtta taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatgg acagcctgag agccgaggac acggctgtct attactgtgc gagttataac      300

tggaactact ggtacttcga tttctggggc cgtggcaccc tggtcactgt ctcctca         357


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Tyr Asn Trp Asn Tyr Trp Tyr Phe Asp Phe Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
ggattcacct tcagtagtta tgcc                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
atatactatg atggaagtta taaa                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Ile Tyr Tyr Asp Gly Ser Tyr Lys 
1               5               


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
gcgagttata actggaacta ctggtacttc gatttc                                 36


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Ala Ser Tyr Asn Trp Asn Tyr Trp Tyr Phe Asp Phe 
1               5                   10          


<210>  9
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
cagagcatta gcagctat                                                     18


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  13
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
gctgcatcc                                                                9


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Ala Ala Ser 
1           


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
caacagagtt acagtacccc tccgatcacc                                        30


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  17
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
caggtgcagc tggtggagtc tgggggaggc gtggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acttatgaca ttcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtc atatcttttg atggaagtaa tagaaattat      180

ggagactccg tgaagggccg attcaccatc tccagggaca attccgacaa taccctgttt      240

ctggaaatga acaatctgag atttgaagac acggctgtgt attactgtgc gaaagagggc      300

tacggtgttg acttccaaca ctggggccag ggcaccctgg tcaccgtctc ctca            354


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Gly Ser Asn Arg Asn Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asp Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Glu Met Asn Asn Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Tyr Gly Val Asp Phe Gln His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
ggattcacct tcagtactta tgac                                              24


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Gly Phe Thr Phe Ser Thr Tyr Asp 
1               5               


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
atatcttttg atggaagtaa taga                                              24


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Ile Ser Phe Asp Gly Ser Asn Arg 
1               5               


<210>  23
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
gcgaaagagg gctacggtgt tgacttccaa cac                                    33


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Ala Lys Glu Gly Tyr Gly Val Asp Phe Gln His 
1               5                   10      


<210>  25
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt aattactact ggacctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggcat atctctaaca gtgggaccac caactataac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgacct ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgag actccccctc      300

ggtattgcag cagttgatac agattattat tattacttcg gtatggacgt ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210>  26
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Ser Asn Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Pro Leu Gly Ile Ala Ala Val Asp Thr Asp Tyr Tyr Tyr Tyr 
            100                 105                 110         


Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
ggtggctcca tcagtaatta ctac                                              24


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Gly Gly Ser Ile Ser Asn Tyr Tyr 
1               5               


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
atctctaaca gtgggaccac c                                                 21


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Ile Ser Asn Ser Gly Thr Thr 
1               5           


<210>  31
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
gcgagactcc ccctcggtat tgcagcagtt gatacagatt attattatta cttcggtatg       60

gacgtc                                                                  66


<210>  32
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Ala Arg Leu Pro Leu Gly Ile Ala Ala Val Asp Thr Asp Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Phe Gly Met Asp Val 
            20          


<210>  33
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtacag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaagct      120

ccagggaagg gactggagtg ggtctctggt attaattgga atggtggtag aacagaatat      180

gcagacgctg tgaagggccg attcatcatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt atttctgtgc gagaacggaa      300

ttacggtggg actactgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  34
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Arg Thr Glu Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Glu Leu Arg Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
ggattcacct ttgatgatta tggc                                              24


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Gly Phe Thr Phe Asp Asp Tyr Gly 
1               5               


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37
attaattgga atggtggtag aaca                                              24


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Ile Asn Trp Asn Gly Gly Arg Thr 
1               5               


<210>  39
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39
gcgagaacgg aattacggtg ggactac                                           27


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Ala Arg Thr Glu Leu Arg Trp Asp Tyr 
1               5                   


<210>  41
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggact caccttcagt agttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagtg ctggtagtac caaatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gggctataac      300

tacgcctact actacttcgg tgtggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  42
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ala Gly Ser Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Tyr Asn Tyr Ala Tyr Tyr Tyr Phe Gly Val Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43
ggactcacct tcagtagtta tgaa                                              24


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Gly Leu Thr Phe Ser Ser Tyr Glu 
1               5               


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45
attagtagtg ctggtagtac caaa                                              24


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46

Ile Ser Ser Ala Gly Ser Thr Lys 
1               5               


<210>  47
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47
gcgggctata actacgccta ctactacttc ggtgtggacg tc                          42


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48

Ala Gly Tyr Asn Tyr Ala Tyr Tyr Tyr Phe Gly Val Asp Val 
1               5                   10                  


<210>  49
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

atttgcactg tctctggtgg ctccatcagc agtaataatt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggaatggatt gggaatttgt atggtagtgg gagtacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagttttgt gaccgccgca gacacggctg tgtatcactg tgcgagatgg      300

gacactaacg ggggggcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      360


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Leu Tyr Gly Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Phe Val Thr Ala Ala Asp Thr Ala Val Tyr His 
                85                  90                  95      


Cys Ala Arg Trp Asp Thr Asn Gly Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
ggtggctcca tcagcagtaa taattactac                                        30


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52

Gly Gly Ser Ile Ser Ser Asn Asn Tyr Tyr 
1               5                   10  


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
ttgtatggta gtgggagtac c                                                 21


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54

Leu Tyr Gly Ser Gly Ser Thr 
1               5           


<210>  55
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
gcgagatggg acactaacgg gggggctttt gatatc                                 36


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56

Ala Arg Trp Asp Thr Asn Gly Gly Ala Phe Asp Ile 
1               5                   10          


<210>  57
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agccttggaa tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgcct acagtggtaa tagagactat      180

gcacagaagt tccagggcag agtcaccatg accacagaca catccacgag cacagcctat      240

atggagctga ggagcctgag atctgacgac acggccgtgt attattgtgc gagatctcta      300

cgttttgact actggggcca gggaaccctg gtcaccgtct cctca                      345


<210>  58
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Leu 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Ser Gly Asn Arg Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
ggttacacct ttaccagcct tgga                                              24


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60

Gly Tyr Thr Phe Thr Ser Leu Gly 
1               5               


<210>  61
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
atcagcgcct acagtggtaa taga                                              24


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62

Ile Ser Ala Tyr Ser Gly Asn Arg 
1               5               


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
gcgagatctc tacgttttga ctac                                              24


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64

Ala Arg Ser Leu Arg Phe Asp Tyr 
1               5               


<210>  65
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctcaggatt caccttggat gattttgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagcggtaa tataggttat      180

gcggactctg tgaagggccg cttcaccatc tccagagaca acgccaggaa ctccctgtat      240

ctgcaaatga acagtctgag agcggaagac acggccttgt attactgcac ctcgggatac      300

tacctctact acgctatgga cgtctggggc caggggacca cggtcaccgt ctcctca         357


<210>  66
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Phe 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Gly Tyr Tyr Leu Tyr Tyr Ala Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67
ggattcacct tggatgattt tgcc                                              24


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68

Gly Phe Thr Leu Asp Asp Phe Ala 
1               5               


<210>  69
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69
attagttgga atagcggtaa tata                                              24


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70

Ile Ser Trp Asn Ser Gly Asn Ile 
1               5               


<210>  71
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71
acctcgggat actacctcta ctacgctatg gacgtc                                 36


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72

Thr Ser Gly Tyr Tyr Leu Tyr Tyr Ala Met Asp Val 
1               5                   10          


<210>  73
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73
caggtgcagc tggtgcagtc tgggcctgag gtgaagaagc ctgggtcttc ggtgaaggtc       60

tcctgcaagg cttctggagg caccatcgac agaaatgaaa tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagta atcatcccta tcttaggtga ggcacactac      180

gaacgaaaat tccagggcag actcacgatt accatggacg agtccacgag tacagcctat      240

atggaactga gtaatctgag atctgaggac acggccgtat attactgtgc gagagagagg      300

gcagctcgag gctaccttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  74
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Asp Arg Asn 
            20                  25                  30          


Glu Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ile Pro Ile Leu Gly Glu Ala His Tyr Glu Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Met Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ala Ala Arg Gly Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75
ggaggcacca tcgacagaaa tgaa                                              24


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76

Gly Gly Thr Ile Asp Arg Asn Glu 
1               5               


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  77
atcatcccta tcttaggtga ggca                                              24


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78

Ile Ile Pro Ile Leu Gly Glu Ala 
1               5               


<210>  79
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79
gcgagagaga gggcagctcg aggctacctt gactac                                 36


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80

Ala Arg Glu Arg Ala Ala Arg Gly Tyr Leu Asp Tyr 
1               5                   10          


<210>  81
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  81
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtacag cctctggatt caccttcagt aattatgcta tattctgggt ccgccaggct      120

ccagggaagg gactggaata tgtttcaggt attagtaata atggggttac taaatattat      180

gcagactctg tgagggacag attcaccatc tccagagaca attccaggaa cacggtgtct      240

attcaaatgg acagcctgag aactgaggac atggctgtgt attactgtgc gcgagaaaac      300

tggggatcgg acgatggttt tgatatctgg ggccaaggaa caatggtcac cgtctcttca      360


<210>  82
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Gly Ile Ser Asn Asn Gly Val Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Val Ser 
65                  70                  75                  80  


Ile Gln Met Asp Ser Leu Arg Thr Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Trp Gly Ser Asp Asp Gly Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  83
ggattcacct tcagtaatta tgct                                              24


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  84

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  85
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  85
attagtaata atggggttac taaa                                              24


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  86

Ile Ser Asn Asn Gly Val Thr Lys 
1               5               


<210>  87
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  87
gcgcgagaaa actggggatc ggacgatggt tttgatatc                              39


<210>  88
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  88

Ala Arg Glu Asn Trp Gly Ser Asp Asp Gly Phe Asp Ile 
1               5                   10              


<210>  89
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  89
caggtgcagt tggtgcagtc tgggactgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc acctatccta tcaattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac ggcaagctac      180

gcacagaagt tccagggcag agtcgcgatt accacggacg aatccacgag cacagcctac      240

atggagctga acagcctgag atctgaggac acggccgtgt attattgtgc gagagagagg      300

ccgaactggg gatctaatga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  90
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Pro Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Pro Asn Trp Gly Ser Asn Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  91
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  91
ggaggcacct tcagcaccta tcct                                              24


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  92

Gly Gly Thr Phe Ser Thr Tyr Pro 
1               5               


<210>  93
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  93
atcatcccta tctttggtac ggca                                              24


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  94

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  95
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  95
gcgagagaga ggccgaactg gggatctaat gactac                                 36


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  96

Ala Arg Glu Arg Pro Asn Trp Gly Ser Asn Asp Tyr 
1               5                   10          


<210>  97
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  97
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

gcctgtgcag cgtctggatt cacctttaga agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atctggtatg atggaagtaa taaatactat      180

acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctatgt attactgtgc gatagacaaa      300

tgggctacgg tgactacgta cctgtttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  98
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  98

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Asp Lys Trp Ala Thr Val Thr Thr Tyr Leu Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  99
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  99
ggattcacct ttagaagtta tggc                                              24


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  100

Gly Phe Thr Phe Arg Ser Tyr Gly 
1               5               


<210>  101
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  101
atctggtatg atggaagtaa taaa                                              24


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  102

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  103
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  103
gcgatagaca aatgggctac ggtgactacg tacctgtttg actac                       45


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  104

Ala Ile Asp Lys Trp Ala Thr Val Thr Thr Tyr Leu Phe Asp Tyr 
1               5                   10                  15  


<210>  105
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105
gaggtgcagc tggtggagtc tgggggaggc ttggtacagt ctggagggtc cctgagactc       60

tcttgtgcag cctctggatt caccttcagt cgttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttgcatat attagtaata ctggtactac cagggactat      180

tcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactatat      240

ctacaaatga gcagcctgag agtcgaggac acggctgttt attattgtgt gagagagaaa      300

tttagtggga cctctgactg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  106
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Thr Gly Thr Thr Arg Asp Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Phe Ser Gly Thr Ser Asp Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  107
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  107
ggattcacct tcagtcgtta tgaa                                              24


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  108

Gly Phe Thr Phe Ser Arg Tyr Glu 
1               5               


<210>  109
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  109
attagtaata ctggtactac cagg                                              24


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  110

Ile Ser Asn Thr Gly Thr Thr Arg 
1               5               


<210>  111
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  111
gtgagagaga aatttagtgg gacctctgac tggttcgacc cc                          42


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  112

Val Arg Glu Lys Phe Ser Gly Thr Ser Asp Trp Phe Asp Pro 
1               5                   10                  


<210>  113
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  113
gaggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctatgcca tgaactgggt ccgccaggct      120

ccagggaagg ggctggaatg ggtctcagct attagtggta gtggtgatag cacatactac      180

acagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acggccgtat attactgtgc gaaagaggag      300

attgttatgt tggtaggtgc taccccgggg tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210>  114
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Ile Val Met Leu Val Gly Ala Thr Pro Gly Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  115
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  115
ggattcacct ttagtagcta tgcc                                              24


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  116

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  117
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  117
attagtggta gtggtgatag caca                                              24


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  118

Ile Ser Gly Ser Gly Asp Ser Thr 
1               5               


<210>  119
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  119
gcgaaagagg agattgttat gttggtaggt gctaccccgg ggtggttcga cccc             54


<210>  120
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  120

Ala Lys Glu Glu Ile Val Met Leu Val Gly Ala Thr Pro Gly Trp Phe 
1               5                   10                  15      


Asp Pro 
        


<210>  121
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  121
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agttactgga tcgactgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg atgactctga taccagatac      180

agtccgtcct tccaaggcca ggtcaccatg tcagtcgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatat attactgtgc gagacatgag      300

agaggtatag tagaagctgg tacggattac tactactact acggtatgga cgtctggggc      360

caagggacca cggtcaccgt ctcctca                                          387


<210>  122
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  122

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asp Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Arg Gly Ile Val Glu Ala Gly Thr Asp Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  123
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  123
ggatacagtt ttaccagtta ctgg                                              24


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  124

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  125
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  125
atctatcctg atgactctga tacc                                              24


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  126

Ile Tyr Pro Asp Asp Ser Asp Thr 
1               5               


<210>  127
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  127
gcgagacatg agagaggtat agtagaagct ggtacggatt actactacta ctacggtatg       60

gacgtc                                                                  66


<210>  128
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  128

Ala Arg His Glu Arg Gly Ile Val Glu Ala Gly Thr Asp Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val 
            20          


<210>  129
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  129
caggttcagc tggtgcagtc tggagctgag gtgatgaagc ctggggcctc agtgaaggtc       60

tcctgcaggg cttctggtta cacctttagc agctatgata tcaactgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggatgg atcagcactg ccactggtaa cacaaactat      180

ccacagaagg tccagggcag agtcaccatg accacagaca catcaacgaa cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtat attattgtac gagagagggc      300

aattcgaagg gctggctcga cccctggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  130
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  130

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Ala Thr Gly Asn Thr Asn Tyr Pro Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Asn Ser Lys Gly Trp Leu Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  131
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  131
ggttacacct ttagcagcta tgat                                              24


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  132

Gly Tyr Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  133
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  133
atcagcactg ccactggtaa caca                                              24


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  134

Ile Ser Thr Ala Thr Gly Asn Thr 
1               5               


<210>  135
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  135
acgagagagg gcaattcgaa gggctggctc gacccc                                 36


<210>  136
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  136

Thr Arg Glu Gly Asn Ser Lys Gly Trp Leu Asp Pro 
1               5                   10          


<210>  137
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  137
caggtacagc tgcagcagtc aggtcccgga caaatgaagt cctcgcagac cctcacactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctatttggta ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg gggaggacaa agttcaggtc caaatggtat      180

aatgattttg cactatctat gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcacctgaa ctctgtgact cccgaggaca cggctgtata ttactgtgca      300

agatataagt gggaacttta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  138
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  138

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Gln Met Lys Ser Ser Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ile Trp Tyr Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Lys Phe Arg Ser Lys Trp Tyr Asn Asp Phe Ala 
    50                  55                  60                  


Leu Ser Met Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu His Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Tyr Lys Trp Glu Leu Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  139
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  139
ggggacagtg tctctagcaa cagtgctatt                                        30


<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  140

Gly Asp Ser Val Ser Ser Asn Ser Ala Ile 
1               5                   10  


<210>  141
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  141
acaaagttca ggtccaaatg gtataat                                           27


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  142

Thr Lys Phe Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  143
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  143
gcaagatata agtgggaact ttactttgac tac                                    33


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  144

Ala Arg Tyr Lys Trp Glu Leu Tyr Phe Asp Tyr 
1               5                   10      


<210>  145
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  145
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt acctattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaggaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagagggt      300

tttggagtgg ttacctatat ctggggccaa gggacaatgg tcaccgtctc ttca            354


<210>  146
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  146

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Phe Gly Val Val Thr Tyr Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  147
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  147
ggattcacct ttagtaccta ttgg                                              24


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  148

Gly Phe Thr Phe Ser Thr Tyr Trp 
1               5               


<210>  149
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  149
ataaaggaag atggaagtga gaaa                                              24


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  150

Ile Lys Glu Asp Gly Ser Glu Lys 
1               5               


<210>  151
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  151
gcgagagagg gttttggagt ggttacctat atc                                    33


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  152

Ala Arg Glu Gly Phe Gly Val Val Thr Tyr Ile 
1               5                   10      


<210>  153
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  153
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactata tgacctggat ccgccagact      120

ccagggaagg ggctggattg ggtttcatac attagttcta gtggtactaa caaatacaac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgcg agccgaggac acggccgtat attactgtgt gagagacccc      300

ccctggggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a               351


<210>  154
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  154

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Thr Asn Lys Tyr Asn Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Pro Trp Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  155
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  155
ggattcacct tcagtgacta ctat                                              24


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  156

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  157
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  157
attagttcta gtggtactaa caaa                                              24


<210>  158
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  158

Ile Ser Ser Ser Gly Thr Asn Lys 
1               5               


<210>  159
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  159
gtgagagacc ccccctgggg tatggacgtc                                        30


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  160

Val Arg Asp Pro Pro Trp Gly Met Asp Val 
1               5                   10  


<210>  161
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  161
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgttg cctctggatt caccttcaat aaatacgaca tgcactgggt ccgccaaact      120

actggaaaag gtctagagtg ggtctcaggt attgatactg atggtgacac atactatcca      180

ggctccgtga agggccgatt caccatctcc agagaaaatg ccgagaactc cctgtatctt      240

caaatgaacg gcctgagagt cggggacacg gctgtgtatt actgtgcaag atggccttgg      300

agtggtttct atggtgcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      360


<210>  162
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Thr Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Thr Asp Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Glu Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Val Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Pro Trp Ser Gly Phe Tyr Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  163
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  163
ggattcacct tcaataaata cgac                                              24


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  164

Gly Phe Thr Phe Asn Lys Tyr Asp 
1               5               


<210>  165
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  165
attgatactg atggtgacac a                                                 21


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  166

Ile Asp Thr Asp Gly Asp Thr 
1               5           


<210>  167
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  167
gcaagatggc cttggagtgg tttctatggt gcttttgata tc                          42


<210>  168
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  168

Ala Arg Trp Pro Trp Ser Gly Phe Tyr Gly Ala Phe Asp Ile 
1               5                   10                  


<210>  169
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  169
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agcggtggtg actactggag ctggatccgc      120

cagctcccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcgcctac      180

tataatccgt ccctcaagag tcgaggtacc atatcaatag acacgtctaa gaaccagttc      240

tccctgaagc tgacctctgt gactgccgcg gacacggccg tatatttctg tgtgaaatta      300

cgatttttgg agtggttctt ggggggctgg ttcggcccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  170
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  170

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Asp Tyr Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ala Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Gly Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Val Lys Leu Arg Phe Leu Glu Trp Phe Leu Gly Gly Trp Phe Gly 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  171
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  171
ggtggctcca tcagcagcgg tggtgactac                                        30


<210>  172
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  172

Gly Gly Ser Ile Ser Ser Gly Gly Asp Tyr 
1               5                   10  


<210>  173
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  173
atctattaca gtgggagcgc c                                                 21


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  174

Ile Tyr Tyr Ser Gly Ser Ala 
1               5           


<210>  175
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  175
gtgaaattac gatttttgga gtggttcttg gggggctggt tcggcccc                    48


<210>  176
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  176

Val Lys Leu Arg Phe Leu Glu Trp Phe Leu Gly Gly Trp Phe Gly Pro 
1               5                   10                  15      


<210>  177
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  177
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc aactatggca tgacctgggt ccgccaggct      120

ccagggaagg gcctggaatg ggtctcagct attactggtg gtggtggtag cacatactac      180

tcaaactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacggtgtat      240

ctgcgaatga acagtgtgag agccgaggac acggccgtat attactgtgc gaaatataag      300

tggaacttcg tggacgactg gggccaggga accacggtca ccgtctcctc a               351


<210>  178
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Gly Gly Gly Gly Ser Thr Tyr Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Lys Trp Asn Phe Val Asp Asp Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  179
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  179
ggattcacct ttagcaacta tggc                                              24


<210>  180
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  180

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  181
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  181
attactggtg gtggtggtag caca                                              24


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  182

Ile Thr Gly Gly Gly Gly Ser Thr 
1               5               


<210>  183
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  183
gcgaaatata agtggaactt cgtggacgac                                        30


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  184

Ala Lys Tyr Lys Trp Asn Phe Val Asp Asp 
1               5                   10  


<210>  185
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human GP130  UniProtKB - Q17RA0

<400>  185

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  186
<211>  1165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human LEPR (UniProtKB/Swiss-Prot Accession No. P48357)

<400>  186

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu 
                885                 890                 895     


His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro Leu Leu 
            900                 905                 910         


Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr Ser Trp 
        915                 920                 925             


Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu Leu Ser 
    930                 935                 940                 


Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn 
945                 950                 955                 960 


Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Asp 
                965                 970                 975     


Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn 
            980                 985                 990         


Ser Lys Pro Ser Glu Thr Gly Glu  Glu Gln Gly Leu Ile  Asn Ser Ser 
        995                 1000                 1005             


Val Thr  Lys Cys Phe Ser Ser  Lys Asn Ser Pro Leu  Lys Asp Ser 
    1010                 1015                 1020             


Phe Ser  Asn Ser Ser Trp Glu  Ile Glu Ala Gln Ala  Phe Phe Ile 
    1025                 1030                 1035             


Leu Ser  Asp Gln His Pro Asn  Ile Ile Ser Pro His  Leu Thr Phe 
    1040                 1045                 1050             


Ser Glu  Gly Leu Asp Glu Leu  Leu Lys Leu Glu Gly  Asn Phe Pro 
    1055                 1060                 1065             


Glu Glu  Asn Asn Asp Lys Lys  Ser Ile Tyr Tyr Leu  Gly Val Thr 
    1070                 1075                 1080             


Ser Ile  Lys Lys Arg Glu Ser  Gly Val Leu Leu Thr  Asp Lys Ser 
    1085                 1090                 1095             


Arg Val  Ser Cys Pro Phe Pro  Ala Pro Cys Leu Phe  Thr Asp Ile 
    1100                 1105                 1110             


Arg Val  Leu Gln Asp Ser Cys  Ser His Phe Val Glu  Asn Asn Ile 
    1115                 1120                 1125             


Asn Leu  Gly Thr Ser Ser Lys  Lys Thr Phe Ala Ser  Tyr Met Pro 
    1130                 1135                 1140             


Gln Phe  Gln Thr Cys Ser Thr  Gln Thr His Lys Ile  Met Glu Asn 
    1145                 1150                 1155             


Lys Met  Cys Asp Leu Thr Val  
    1160                 1165 


<210>  187
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLEPR-MMH

<400>  187

Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu Ser Cys 
1               5                   10                  15      


Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala Gly Leu 
            20                  25                  30          


Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr Glu Thr Ala Val Glu 
        35                  40                  45              


Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser Asn Leu Ser Lys Thr 
    50                  55                  60                  


Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys Ser Leu 
65                  70                  75                  80  


Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val Asn Ser 
                85                  90                  95      


Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn Ile Gln Cys Trp Leu 
            100                 105                 110         


Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu Phe Lys 
        115                 120                 125             


Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His Leu Leu Tyr Val Leu 
    130                 135                 140                 


Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly Ser Phe 
145                 150                 155                 160 


Gln Met Val His Cys Asn Cys Ser Val His Glu Cys Cys Glu Cys Leu 
                165                 170                 175     


Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met Cys Leu 
            180                 185                 190         


Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met Ser Val 
        195                 200                 205             


Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu His Met 
    210                 215                 220                 


Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser Pro Pro 
225                 230                 235                 240 


Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Ser Glu Asn Ser 
                245                 250                 255     


Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr Ser Leu 
            260                 265                 270         


Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg 
        275                 280                 285             


Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser Thr Pro 
    290                 295                 300                 


Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys Ile Leu 
305                 310                 315                 320 


Thr Ser Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys Lys Glu 
                325                 330                 335     


Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp Trp Met Asn Leu Ala 
            340                 345                 350         


Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His Val Ser 
        355                 360                 365             


Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly Lys Phe 
    370                 375                 380                 


Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His His Arg 
385                 390                 395                 400 


Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu 
                405                 410                 415     


Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Ser Thr 
            420                 425                 430         


Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu Arg Tyr His Arg Ser 
        435                 440                 445             


Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His Pro Ile Ser Glu Pro 
    450                 455                 460                 


Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile Phe Gln 
465                 470                 475                 480 


Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His 
                485                 490                 495     


Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser 
            500                 505                 510         


Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Thr Ile 
        515                 520                 525             


Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu 
    530                 535                 540                 


Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Val 
545                 550                 555                 560 


Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser Val Ser 
                565                 570                 575     


Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala Val Gln Val Arg Cys 
            580                 585                 590         


Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn Pro Ala 
        595                 600                 605             


Tyr Thr Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro Glu Phe 
    610                 615                 620                 


Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn Val Thr 
625                 630                 635                 640 


Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Gln 
                645                 650                 655     


Arg Tyr Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp Ser Glu 
            660                 665                 670         


Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu Gln Ala 
        675                 680                 685             


His Thr Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Val Ala 
    690                 695                 700                 


Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ile Val 
705                 710                 715                 720 


Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile Val Ser 
                725                 730                 735     


Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile Ile Glu 
            740                 745                 750         


Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg Ile Ser 
        755                 760                 765             


Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro Ile Glu 
    770                 775                 780                 


Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val Gly Lys 
785                 790                 795                 800 


Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp Ile Glu Lys His Gln 
                805                 810                 815     


Ser Asp Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln 
            820                 825                 830         


Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
        835                 840                 845     


<210>  188
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MfLEPR-MMH

<400>  188

Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu Ser Cys 
1               5                   10                  15      


Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala Gly Leu 
            20                  25                  30          


Ser Lys Asn Thr Ser Asn Leu Asn Gly His Tyr Glu Thr Ala Val Glu 
        35                  40                  45              


Phe Asn Ser Ser Asp Thr His Phe Ser Asn Leu Ser Lys Thr Thr Phe 
    50                  55                  60                  


His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys Ser Leu Cys Ala 
65                  70                  75                  80  


Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val Asn Ser Ser Val 
                85                  90                  95      


Phe Gln Gln Met Gly Ala Asn Trp Asn Ile Gln Cys Trp Leu Lys Gly 
            100                 105                 110         


Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu Phe Lys Asn Pro 
        115                 120                 125             


Phe Lys Asn Tyr Lys His Lys Val His Leu Leu Tyr Val Leu Pro Glu 
    130                 135                 140                 


Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly Ser Phe Gln Met 
145                 150                 155                 160 


Val His Cys Asn Cys Ser Val His Glu Arg Cys Glu Cys Leu Val Pro 
                165                 170                 175     


Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met Cys Leu Lys Ile 
            180                 185                 190         


Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met Ser Val Gln Pro 
        195                 200                 205             


Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu Arg Met Glu Ile 
    210                 215                 220                 


Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser Pro Pro Leu Val 
225                 230                 235                 240 


Pro Phe Pro Leu Gln Tyr Glu Val Lys Tyr Ser Glu Asn Ser Thr Thr 
                245                 250                 255     


Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr Ser Leu Leu Val 
            260                 265                 270         


Asp Gly Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg Gly Lys 
        275                 280                 285             


Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser Thr Pro His Val 
    290                 295                 300                 


Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys Ile Leu Thr Ser 
305                 310                 315                 320 


Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys Asn Glu Asn Lys 
                325                 330                 335     


Ile Val Ser Ser Lys Lys Ile Val Trp Trp Met Asn Leu Ala Glu Lys 
            340                 345                 350         


Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His Val Ser Lys Val 
        355                 360                 365             


Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly Lys Phe Thr Tyr 
    370                 375                 380                 


Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His His Arg Tyr Ala 
385                 390                 395                 400 


Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu Thr Asp 
                405                 410                 415     


Gly His Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Asn Thr Ile Gln 
            420                 425                 430         


Ser Leu Ala Gly Ser Thr Leu Gln Leu Arg Tyr Arg Arg Ser Ser Leu 
        435                 440                 445             


Tyr Cys Phe Asp Ile Pro Ser Ile His Pro Ile Ser Lys Pro Lys Asp 
    450                 455                 460                 


Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Val Phe Gln Pro Ile 
465                 470                 475                 480 


Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His Pro Leu 
                485                 490                 495     


Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser Val Val 
            500                 505                 510         


Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Ile Lys Asn Ile 
        515                 520                 525             


Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu Asn Asn 
    530                 535                 540                 


Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Ile Gln Trp 
545                 550                 555                 560 


Lys Met Tyr Asp Val Tyr Asp Ala Lys Ser Lys Ser Val Ser Leu Pro 
                565                 570                 575     


Val Pro Asp Phe Cys Ala Val Tyr Ala Val Gln Val Arg Cys Lys Arg 
            580                 585                 590         


Ser Asp Gly Leu Gly Leu Trp Ser Asn Trp Ser Asn Pro Ala Tyr Thr 
        595                 600                 605             


Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro Glu Phe Trp Arg 
    610                 615                 620                 


Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn Val Thr Leu Leu 
625                 630                 635                 640 


Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Gln Arg Tyr 
                645                 650                 655     


Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp Ser Glu Asp Val 
            660                 665                 670         


Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu Gln Ala His Thr 
        675                 680                 685             


Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Val Ala Asn Phe 
    690                 695                 700                 


Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ile Val Gln Ser 
705                 710                 715                 720 


Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile Leu Ser Trp Ile 
                725                 730                 735     


Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile Ile Glu Trp Lys 
            740                 745                 750         


Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg Ile Ser Ser Ser 
        755                 760                 765             


Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro Ile Glu Lys Tyr 
    770                 775                 780                 


Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val Gly Lys Pro Lys 
785                 790                 795                 800 


Ile Ile Asn Ser Phe Ala Gln Asp Asn Thr Glu Lys His Gln Asn Asp 
                805                 810                 815     


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu 
            820                 825                 830         


Ile Ser Glu Glu Asp Leu His His His His His His 
        835                 840                 


<210>  189
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLEPR-hFc

<400>  189

Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu Ser Cys 
1               5                   10                  15      


Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala Gly Leu 
            20                  25                  30          


Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr Glu Thr Ala Val Glu 
        35                  40                  45              


Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser Asn Leu Ser Lys Thr 
    50                  55                  60                  


Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys Ser Leu 
65                  70                  75                  80  


Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val Asn Ser 
                85                  90                  95      


Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn Ile Gln Cys Trp Leu 
            100                 105                 110         


Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu Phe Lys 
        115                 120                 125             


Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His Leu Leu Tyr Val Leu 
    130                 135                 140                 


Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly Ser Phe 
145                 150                 155                 160 


Gln Met Val His Cys Asn Cys Ser Val His Glu Cys Cys Glu Cys Leu 
                165                 170                 175     


Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met Cys Leu 
            180                 185                 190         


Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met Ser Val 
        195                 200                 205             


Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu His Met 
    210                 215                 220                 


Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser Pro Pro 
225                 230                 235                 240 


Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Ser Glu Asn Ser 
                245                 250                 255     


Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr Ser Leu 
            260                 265                 270         


Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln Val Arg 
        275                 280                 285             


Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser Thr Pro 
    290                 295                 300                 


Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys Ile Leu 
305                 310                 315                 320 


Thr Ser Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys Lys Glu 
                325                 330                 335     


Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp Trp Met Asn Leu Ala 
            340                 345                 350         


Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His Val Ser 
        355                 360                 365             


Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly Lys Phe 
    370                 375                 380                 


Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His His Arg 
385                 390                 395                 400 


Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser Cys Glu 
                405                 410                 415     


Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Ser Thr 
            420                 425                 430         


Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu Arg Tyr His Arg Ser 
        435                 440                 445             


Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His Pro Ile Ser Glu Pro 
    450                 455                 460                 


Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile Phe Gln 
465                 470                 475                 480 


Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His 
                485                 490                 495     


Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser 
            500                 505                 510         


Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Thr Ile 
        515                 520                 525             


Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu 
    530                 535                 540                 


Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Val 
545                 550                 555                 560 


Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser Val Ser 
                565                 570                 575     


Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala Val Gln Val Arg Cys 
            580                 585                 590         


Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn Pro Ala 
        595                 600                 605             


Tyr Thr Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro Glu Phe 
    610                 615                 620                 


Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn Val Thr 
625                 630                 635                 640 


Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser Val Gln 
                645                 650                 655     


Arg Tyr Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp Ser Glu 
            660                 665                 670         


Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu Gln Ala 
        675                 680                 685             


His Thr Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser Val Ala 
    690                 695                 700                 


Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn Ile Val 
705                 710                 715                 720 


Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile Val Ser 
                725                 730                 735     


Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile Ile Glu 
            740                 745                 750         


Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg Ile Ser 
        755                 760                 765             


Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro Ile Glu 
    770                 775                 780                 


Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val Gly Lys 
785                 790                 795                 800 


Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp Ile Glu Lys His Gln 
                805                 810                 815     


Ser Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            820                 825                 830         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        835                 840                 845             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    850                 855                 860                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
865                 870                 875                 880 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                885                 890                 895     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            900                 905                 910         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        915                 920                 925             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    930                 935                 940                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
945                 950                 955                 960 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                965                 970                 975     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            980                 985                 990         


Pro Pro Val Leu Asp Ser Asp Gly  Ser Phe Phe Leu Tyr  Ser Lys Leu 
        995                 1000                 1005             


Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly Asn Val  Phe Ser Cys 
    1010                 1015                 1020             


Ser Val  Met His Glu Ala Leu  His Asn His Tyr Thr  Gln Lys Ser 
    1025                 1030                 1035             


Leu Ser  Leu Ser Pro Gly Lys  
    1040                 1045 


<210>  190
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGP130-mFc

<400>  190

Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
        595                 600                 605             


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
    610                 615                 620                 


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
625                 630                 635                 640 


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
                645                 650                 655     


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
            660                 665                 670         


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
        675                 680                 685             


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
    690                 695                 700                 


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
705                 710                 715                 720 


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
                725                 730                 735     


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
            740                 745                 750         


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
        755                 760                 765             


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
    770                 775                 780                 


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
785                 790                 795                 800 


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
                805                 810                 815     


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            820                 825                 830 


<210>  191
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGP130-MMH

<400>  191

Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
        595                 600                 605             


Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His 
    610                 615                 620                 


His 
625 


<210>  192
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGP130 delta D1-MMH

<400>  192

Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly 
1               5                   10                  15      


Lys Lys Met Arg Cys Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu 
            20                  25                  30          


Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp 
        35                  40                  45              


Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser 
    50                  55                  60                  


Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala 
65                  70                  75                  80  


Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys 
                85                  90                  95      


Val Lys Pro Asn Pro Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu 
            100                 105                 110         


Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser 
        115                 120                 125             


Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser 
    130                 135                 140                 


Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser 
145                 150                 155                 160 


Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile 
                165                 170                 175     


Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu 
            180                 185                 190         


Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser 
        195                 200                 205             


Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val 
    210                 215                 220                 


Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile 
225                 230                 235                 240 


Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn 
                245                 250                 255     


Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg 
            260                 265                 270         


Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala 
        275                 280                 285             


Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val 
    290                 295                 300                 


Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp 
305                 310                 315                 320 


Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val 
                325                 330                 335     


Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly 
            340                 345                 350         


Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys 
        355                 360                 365             


Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro 
    370                 375                 380                 


Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro 
385                 390                 395                 400 


Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp 
                405                 410                 415     


Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr 
            420                 425                 430         


Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp 
        435                 440                 445             


Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu 
    450                 455                 460                 


Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly 
465                 470                 475                 480 


Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu 
                485                 490                 495     


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu 
            500                 505                 510         


Ile Ser Glu Glu Asp Leu His His His His His His 
        515                 520                 


<210>  193
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGP130 delta D1-D3-MMH

<400>  193

Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln Gly Tyr 
1               5                   10                  15      


Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu Ala Asn 
            20                  25                  30          


Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys Ser His 
        35                  40                  45              


Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn Leu Thr 
    50                  55                  60                  


Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val Gly Lys 
65                  70                  75                  80  


Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln Ala Thr 
                85                  90                  95      


His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met Leu Trp 
            100                 105                 110         


Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile Leu Glu 
        115                 120                 125             


Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp Gln Gln 
    130                 135                 140                 


Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu Ala Glu 
145                 150                 155                 160 


Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp Gly Pro 
                165                 170                 175     


Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro Pro Ser 
            180                 185                 190         


Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val 
        195                 200                 205             


Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe Ile Arg 
    210                 215                 220                 


Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr Ala Val 
225                 230                 235                 240 


Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu Thr Ser 
                245                 250                 255     


Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly 
            260                 265                 270         


Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly 
        275                 280                 285             


Glu Ile Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu 
    290                 295                 300                 


Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
305                 310                 315                 


<210>  194
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MfGP130-MMH

<400>  194

Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ser Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asn Arg Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Arg Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Cys Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Asn Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Ala Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Met Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Asp Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Val Ala Thr Leu Thr Ala Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Ala Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr His Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
        595                 600                 605             


Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His 
    610                 615                 620                 


His 
625 


<210>  195
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rGP130-MMH

<400>  195

Gln Leu Val Glu Pro Cys Gly Tyr Ile Tyr Pro Glu Phe Pro Val Val 
1               5                   10                  15      


Gln Arg Gly Ser Asn Phe Thr Ala Thr Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Leu Gln Val Tyr Ser Val Asn Ala Thr Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Val Ala Val Pro Lys Glu Gln Val Thr Val Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Val Val Phe Gln Asn Val Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Ser Phe Gly Gln Ile Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Leu Ser Gly Tyr Pro Pro Asp Ile Pro Thr Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Asn Met Leu Cys Gln Trp Asp Pro Gly Arg 
        115                 120                 125             


Glu Thr Tyr Leu Glu Thr Asn Tyr Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


Glu Lys Phe Pro Asp Cys Arg Thr Lys His Gly Thr Ser Ser Cys Met 
145                 150                 155                 160 


Met Gly Tyr Thr Pro Ile Tyr Phe Val Asn Ile Glu Val Trp Val Glu 
                165                 170                 175     


Ala Glu Asn Ala Leu Gly Asn Val Ser Ser Glu Pro Ile Asn Phe Asp 
            180                 185                 190         


Pro Val Asp Lys Val Lys Pro Ser Pro Pro His Asn Leu Ser Val Thr 
        195                 200                 205             


Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Ala Trp Val Asn Ser 
    210                 215                 220                 


Gly Leu Asp Ser Ile Leu Arg Leu Lys Ser Asp Ile Gln Tyr Arg Thr 
225                 230                 235                 240 


Lys Asp Ala Ser Thr Trp Ile Gln Val Pro Leu Glu Asp Thr Val Ser 
                245                 250                 255     


Pro Arg Thr Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr 
            260                 265                 270         


Val Phe Arg Ile Arg Ser Ile Lys Glu Asn Gly Lys Gly Tyr Trp Ser 
        275                 280                 285             


Asp Trp Ser Glu Glu Ala Ser Gly Thr Thr Tyr Glu Asp Arg Pro Ser 
    290                 295                 300                 


Lys Ala Pro Ser Phe Trp Tyr Lys Val Asn Ala Asn His Pro Gln Glu 
305                 310                 315                 320 


Tyr Arg Ser Ala Arg Leu Ile Trp Lys Thr Leu Pro Leu Ser Glu Ala 
                325                 330                 335     


Asn Gly Lys Ile Leu Asp Tyr Glu Val Val Leu Thr Gln Ser Lys Ser 
            340                 345                 350         


Val Ser Gln Thr Tyr Thr Val Asn Gly Thr Glu Leu Ile Val Asn Leu 
        355                 360                 365             


Thr Asn Asn Arg Tyr Val Ala Ser Leu Ala Ala Arg Asn Val Val Gly 
    370                 375                 380                 


Lys Ser Pro Ala Thr Val Leu Thr Ile Pro Gly Ser His Phe Lys Ala 
385                 390                 395                 400 


Ser His Pro Val Val Asp Leu Lys Ala Phe Pro Lys Asp Asn Leu Leu 
                405                 410                 415     


Trp Val Glu Trp Thr Pro Pro Ser Lys Pro Val Asn Lys Tyr Ile Leu 
            420                 425                 430         


Glu Trp Cys Val Leu Ser Glu Asn Ser Pro Cys Ile Pro Asp Trp Gln 
        435                 440                 445             


Gln Glu Asp Gly Thr Val Asn Arg Thr His Leu Arg Gly Ser Leu Leu 
    450                 455                 460                 


Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Phe Pro Gly Gly 
465                 470                 475                 480 


Pro Gly Ser Pro Glu Ser Met Lys Ala Tyr Leu Lys Gln Ala Ala Pro 
                485                 490                 495     


Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu Ala 
            500                 505                 510         


Val Leu Glu Trp Asp His Leu Pro Val Asp Val Gln Asn Gly Phe Ile 
        515                 520                 525             


Arg Asn Tyr Ser Ile Ser Tyr Arg Thr Ser Val Gly Lys Glu Met Val 
    530                 535                 540                 


Val Arg Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu Ser 
545                 550                 555                 560 


Ser Asp Thr Leu Tyr Met Val His Met Ala Ala Tyr Thr Glu Glu Gly 
                565                 570                 575     


Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Leu Lys Phe Ala Gln 
            580                 585                 590         


Gly Glu Ile Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly 
        595                 600                 605             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
    610                 615                 620                 


<210>  196
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mGP130-MMH

<400>  196

Gln Leu Leu Glu Pro Cys Gly Tyr Ile Tyr Pro Glu Phe Pro Val Val 
1               5                   10                  15      


Gln Arg Gly Ser Asn Phe Thr Ala Ile Cys Val Leu Lys Glu Ala Cys 
            20                  25                  30          


Leu Gln His Tyr Tyr Val Asn Ala Ser Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Ala Ala Val Pro Arg Glu Gln Val Thr Val Ile Asn Arg Thr Thr 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Val Val Leu Pro Ser Val Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Ser Phe Gly Gln Ile Glu Gln Asn Val Tyr Gly Val 
                85                  90                  95      


Thr Met Leu Ser Gly Phe Pro Pro Asp Lys Pro Thr Asn Leu Thr Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Asn Met Leu Cys Gln Trp Asp Pro Gly Arg 
        115                 120                 125             


Glu Thr Tyr Leu Glu Thr Asn Tyr Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


Glu Lys Phe Pro Asp Cys Gln Ser Lys His Gly Thr Ser Cys Met Val 
145                 150                 155                 160 


Ser Tyr Met Pro Thr Tyr Tyr Val Asn Ile Glu Val Trp Val Glu Ala 
                165                 170                 175     


Glu Asn Ala Leu Gly Lys Val Ser Ser Glu Ser Ile Asn Phe Asp Pro 
            180                 185                 190         


Val Asp Lys Val Lys Pro Thr Pro Pro Tyr Asn Leu Ser Val Thr Asn 
        195                 200                 205             


Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Ser Trp Val Ser Ser Gly 
    210                 215                 220                 


Leu Gly Gly Leu Leu Asp Leu Lys Ser Asp Ile Gln Tyr Arg Thr Lys 
225                 230                 235                 240 


Asp Ala Ser Thr Trp Ile Gln Val Pro Leu Glu Asp Thr Met Ser Pro 
                245                 250                 255     


Arg Thr Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val 
            260                 265                 270         


Phe Arg Ile Arg Ser Ile Lys Asp Ser Gly Lys Gly Tyr Trp Ser Asp 
        275                 280                 285             


Trp Ser Glu Glu Ala Ser Gly Thr Thr Tyr Glu Asp Arg Pro Ser Arg 
    290                 295                 300                 


Pro Pro Ser Phe Trp Tyr Lys Thr Asn Pro Ser His Gly Gln Glu Tyr 
305                 310                 315                 320 


Arg Ser Val Arg Leu Ile Trp Lys Ala Leu Pro Leu Ser Glu Ala Asn 
                325                 330                 335     


Gly Lys Ile Leu Asp Tyr Glu Val Ile Leu Thr Gln Ser Lys Ser Val 
            340                 345                 350         


Ser Gln Thr Tyr Thr Val Thr Gly Thr Glu Leu Thr Val Asn Leu Thr 
        355                 360                 365             


Asn Asp Arg Tyr Val Ala Ser Leu Ala Ala Arg Asn Lys Val Gly Lys 
    370                 375                 380                 


Ser Ala Ala Ala Val Leu Thr Ile Pro Ser Pro His Val Thr Ala Ala 
385                 390                 395                 400 


Tyr Ser Val Val Asn Leu Lys Ala Phe Pro Lys Asp Asn Leu Leu Trp 
                405                 410                 415     


Val Glu Trp Thr Pro Pro Pro Lys Pro Val Ser Lys Tyr Ile Leu Glu 
            420                 425                 430         


Trp Cys Val Leu Ser Glu Asn Ala Pro Cys Val Glu Asp Trp Gln Gln 
        435                 440                 445             


Glu Asp Ala Thr Val Asn Arg Thr His Leu Arg Gly Arg Leu Leu Glu 
    450                 455                 460                 


Ser Lys Cys Tyr Gln Ile Thr Val Thr Pro Val Phe Ala Thr Gly Pro 
465                 470                 475                 480 


Gly Gly Ser Glu Ser Leu Lys Ala Tyr Leu Lys Gln Ala Ala Pro Ala 
                485                 490                 495     


Arg Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val 
            500                 505                 510         


Leu Ala Trp Asp Gln Ile Pro Val Asp Asp Gln Asn Gly Phe Ile Arg 
        515                 520                 525             


Asn Tyr Ser Ile Ser Tyr Arg Thr Ser Val Gly Lys Glu Met Val Val 
    530                 535                 540                 


His Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu Ser Ser 
545                 550                 555                 560 


Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly 
                565                 570                 575     


Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly 
            580                 585                 590         


Glu Ile Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu 
        595                 600                 605             


Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
    610                 615                 620             


<210>  197
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGP130-hFc

<400>  197

Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val 
1               5                   10                  15      


Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys 
            20                  25                  30          


Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn 
        35                  40                  45              


His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala 
    50                  55                  60                  


Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu Thr 
65                  70                  75                  80  


Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile 
                85                  90                  95      


Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys 
            100                 105                 110         


Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly Arg 
        115                 120                 125             


Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr 
    130                 135                 140                 


His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys 
145                 150                 155                 160 


Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val 
                165                 170                 175     


Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe 
            180                 185                 190         


Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val 
        195                 200                 205             


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
    210                 215                 220                 


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
225                 230                 235                 240 


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
                245                 250                 255     


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
            260                 265                 270         


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
        275                 280                 285             


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg Pro 
    290                 295                 300                 


Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr Gln 
305                 310                 315                 320 


Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe Glu 
                325                 330                 335     


Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys 
            340                 345                 350         


Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val Asn 
        355                 360                 365             


Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu Val 
    370                 375                 380                 


Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln 
385                 390                 395                 400 


Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met 
                405                 410                 415     


Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile 
            420                 425                 430         


Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp Trp 
        435                 440                 445             


Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn Leu 
    450                 455                 460                 


Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp 
465                 470                 475                 480 


Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro 
                485                 490                 495     


Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu 
            500                 505                 510         


Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe 
        515                 520                 525             


Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr 
    530                 535                 540                 


Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu 
                565                 570                 575     


Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala 
            580                 585                 590         


Gln Gly Glu Ile Glu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        595                 600                 605             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    610                 615                 620                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
625                 630                 635                 640 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                645                 650                 655     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            660                 665                 670         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        675                 680                 685             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    690                 695                 700                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
705                 710                 715                 720 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                725                 730                 735     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            740                 745                 750         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        755                 760                 765             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    770                 775                 780                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
785                 790                 795                 800 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                805                 810                 815     


Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 


<210>  198
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCNTFR-MMH

<400>  198

Gln Arg His Ser Pro Gln Glu Ala Pro His Val Gln Tyr Glu Arg Leu 
1               5                   10                  15      


Gly Ser Asp Val Thr Leu Pro Cys Gly Thr Ala Asn Trp Asp Ala Ala 
            20                  25                  30          


Val Thr Trp Arg Val Asn Gly Thr Asp Leu Ala Pro Asp Leu Leu Asn 
        35                  40                  45              


Gly Ser Gln Leu Val Leu His Gly Leu Glu Leu Gly His Ser Gly Leu 
    50                  55                  60                  


Tyr Ala Cys Phe His Arg Asp Ser Trp His Leu Arg His Gln Val Leu 
65                  70                  75                  80  


Leu His Val Gly Leu Pro Pro Arg Glu Pro Val Leu Ser Cys Arg Ser 
                85                  90                  95      


Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser Trp His Leu Pro Thr Pro 
            100                 105                 110         


Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr Val Leu His Gly Ser Lys 
        115                 120                 125             


Ile Met Val Cys Glu Lys Asp Pro Ala Leu Lys Asn Arg Cys His Ile 
    130                 135                 140                 


Arg Tyr Met His Leu Phe Ser Thr Ile Lys Tyr Lys Val Ser Ile Ser 
145                 150                 155                 160 


Val Ser Asn Ala Leu Gly His Asn Ala Thr Ala Ile Thr Phe Asp Glu 
                165                 170                 175     


Phe Thr Ile Val Lys Pro Asp Pro Pro Glu Asn Val Val Ala Arg Pro 
            180                 185                 190         


Val Pro Ser Asn Pro Arg Arg Leu Glu Val Thr Trp Gln Thr Pro Ser 
        195                 200                 205             


Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu Lys Phe Phe Leu Arg Tyr 
    210                 215                 220                 


Arg Pro Leu Ile Leu Asp Gln Trp Gln His Val Glu Leu Ser Asp Gly 
225                 230                 235                 240 


Thr Ala His Thr Ile Thr Asp Ala Tyr Ala Gly Lys Glu Tyr Ile Ile 
                245                 250                 255     


Gln Val Ala Ala Lys Asp Asn Glu Ile Gly Thr Trp Ser Asp Trp Ser 
            260                 265                 270         


Val Ala Ala His Ala Thr Pro Trp Thr Glu Glu Pro Arg His Leu Thr 
        275                 280                 285             


Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr Ser Thr Thr Ser Ser Leu 
    290                 295                 300                 


Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp Pro Gly Glu Leu Gly Ser 
305                 310                 315                 320 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu 
                325                 330                 335     


Ile Ser Glu Glu Asp Leu His His His His His His 
            340                 345             


