                         SEQUENCE LISTING

<110>  Merck Sharp &  Dohme Corp.
 
<120>  CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY

<130>  24559-US-PCT

<150>  62599997
<151>  2017-12-18

<150>  62625491
<151>  2018-02-02

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
1               5                   10                  15      


Leu Glu Asn Tyr Cys Asn 
            20          


<210>  2
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Val Thr Thr Pro Lys Thr 
            20                  25                  30      


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A - PEPTIDE  and amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (0)..(0)
<223>  Xaa=Any codable amino acid, dequence of codable amino acids, or 
       missing

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa=TYR or ALA

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa=SER or GLY

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa=Ile or Val

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa=ASN, ASP or GLU

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa= ASN ASP GlU GLY or Ala

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa= Any codable amino acids sequence of codable amino acids or 
       missing

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Xaa Gly Ile Val Glu Gln Cys Cys Xaa Xaa Xaa Cys Ser Leu Tyr Gln 
1               5                   10                  15      


Leu Glu Xaa Tyr Cys Xaa Xaa 
            20              


<210>  4
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B - Peptide and three Disulfide bridges as shown in formula X


<220>
<221>  MISC_FEATURE
<222>  (0)..(0)
<223>  Xaa=any codablle amino acid, sequence of codable amino acids, or 
       missing

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa=ASN, LYS, ASP or Glu , or missing

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa=Pro, Ala , Lys Leu, Val or Asp or missing

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa=LYS, Pro, or Glu or missing

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa=Thr Ala Lys Glu Ser aor Arg or Missing

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa=any codable amino acid dequence of codable amino acids, 
       Arg-Arg or missing

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Xaa Phe Val Ala Xaa Gln His Leu Cys Gly Ser His Leu Val Glu Ala 
1               5                   10                  15      


Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  5
<211>  14
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  N-Terminal Protecting Amino Acid


<220>
<221>  MISC_FEATURE
<223>  Xaa=any codable amino acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Asp Xaa Glu Asp Xaa Glu Asp Xaa Glu Asp Xaa Glu Pro Arg 
1               5                   10                  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-TERMINAL PROTECTING AMINO ACID SEQUENCE


<220>
<221>  MISC_FEATURE
<223>  XAA=any codable amino acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Asp Xaa Glu Asp Xaa Glu Gly Asp Xaa Glu Xaa 
1               5                   10      


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal protecting amino acid sequence

<400>  7

Asp Asp Glu Asp Pro Arg 
1               5       


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the N-terminal protecting amino acid sequence comprises

<400>  8

Glu Glu Gly Pro Arg 
1               5   


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the N-terminal protecting amino acid

<400>  9

Asp Asp Gly Arg 
1               


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal protecting amino

<400>  10

Glu Glu Gly Glu Arg 
1               5   


