                         SEQUENCE LISTING

<110>  Birkus, Gabriel
       Pav, Ondrej
       Jandusik, Tomas
       Rosenberg, Ivan
       Nencka, Radim
 
<120>  3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE 
       STING ADAPTOR PROTEIN

<130>  052838-535001US

<150>  62/608,373
<151>  2017-12-20

<150>  62/725,858
<151>  2018-08-31

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
aaagatcttg gaaagtgaaa ccttggaaaa cgaaactgga caaagggaaa ctgcagaaac       60

tgaaacaaag cttaa                                                        75


<210>  2
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
ttaagctttg tttcagtttc tgcagtttcc ctttgtccag tttcgttttc caaggtttca       60

ctttccaaga tcttt                                                        75


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
tgcttgctca actctacgtc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
gtggtttgtc caaactcatc                                                   20


<210>  5
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
gtgggatccg ccccagctga gatctctgca g                                      31


<210>  6
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
tatgcggccg cctattacac agtaacctct tccttttc                               38


<210>  7
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
atgtcgcatc accatcatca tcaccaccat gggatgtcgg actcagaagt caatcaagaa       60

gctaagccag aggtcaagcc agaagtcaag cctgagactc acatcaattt aaaggtgtcc      120

gatggatctt cagagatctt cttcaagatc aaaaagacca ctcctttaag aaggctgatg      180

gaagcgttcg ctaaaagaca gggtaaggaa atggactcct taagattctt gtacgacggt      240

attagaattc aagctgatca gacccctgaa gatttggaca tggaggataa cgatattatt      300

gaggctcacc gcgaacagat tggtggatcc                                       330


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Met Ser His His His His His His His His Gly Met Ser Asp Ser Glu 
1               5                   10                  15      


Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu 
            20                  25                  30          


Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe 
        35                  40                  45              


Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala 
    50                  55                  60                  


Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly 
65                  70                  75                  80  


Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp 
                85                  90                  95      


Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Ser 
            100                 105                 110 


<210>  9
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Ala Pro Ala Glu Ile Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val 
1               5                   10                  15      


Ala His Gly Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile 
            20                  25                  30          


Leu Pro Glu Leu Gln Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn 
        35                  40                  45              


Asn Leu Leu Arg Gly Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro 
    50                  55                  60                  


Leu Asp Cys Gly Val Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile 
65                  70                  75                  80  


Arg Phe Leu Asp Lys Leu Pro Gln Gln Thr Gly Asp Arg Ala Gly Ile 
                85                  90                  95      


Lys Asp Arg Val Tyr Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly 
            100                 105                 110         


Gln Arg Ala Gly Thr Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr 
        115                 120                 125             


Leu Phe Ala Met Ser Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp 
    130                 135                 140                 


Arg Leu Glu Gln Ala Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu 
145                 150                 155                 160 


Ala Asp Ala Pro Glu Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln 
                165                 170                 175     


Glu Pro Ala Asp Asp Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg 
            180                 185                 190         


His Leu Arg Gln Glu Glu Lys Glu Glu Val Thr Val 
        195                 200                 


<210>  10
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Ala Pro Ala Glu Ile Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val 
1               5                   10                  15      


Ala His Gly Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile 
            20                  25                  30          


Leu Pro Glu Leu Gln Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn 
        35                  40                  45              


Asn Leu Leu Arg Gly Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro 
    50                  55                  60                  


Leu Asp Cys Gly Val Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile 
65                  70                  75                  80  


Arg Phe Leu Asp Lys Leu Pro Gln Gln Thr Ala Asp Arg Ala Gly Ile 
                85                  90                  95      


Lys Asp Arg Val Tyr Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly 
            100                 105                 110         


Gln Arg Ala Gly Thr Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr 
        115                 120                 125             


Leu Phe Ala Met Ser Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp 
    130                 135                 140                 


Arg Leu Glu Gln Ala Lys Leu Phe Cys Gln Thr Leu Glu Asp Ile Leu 
145                 150                 155                 160 


Ala Asp Ala Pro Glu Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln 
                165                 170                 175     


Glu Pro Ala Asp Asp Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg 
            180                 185                 190         


His Leu Arg Gln Glu Glu Lys Glu Glu Val Thr Val 
        195                 200                 


<210>  11
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Met Asn Ser Ser His His His His His His Met Gln Tyr Lys Leu Ile 
1               5                   10                  15      


Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp 
            20                  25                  30          


Ala Ala Thr Ala Glu Lys Val Leu Lys Gln Tyr Ala Asn Asp Asn Gly 
        35                  40                  45              


Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val 
    50                  55                  60                  


Thr Glu Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Glu Asn Leu Tyr 
65                  70                  75                  80  


Phe Gln Gly Met Arg Met Thr Trp Asn Phe His Gln Tyr Tyr Thr Asn 
                85                  90                  95      


Arg Asn Asp Gly Leu Met Gly Lys Leu Val Leu Thr Asp Glu Glu Lys 
            100                 105                 110         


Asn Asn Leu Lys Ala Leu Arg Lys Ile Ile Arg Leu Arg Thr Arg Asp 
        115                 120                 125             


Val Phe Glu Glu Ala Lys Gly Ile Ala Lys Ala Val Lys Lys Ser Ala 
    130                 135                 140                 


Leu Thr Phe Glu Ile Ile Gln Glu Lys Val Ser Thr Thr Gln Ile Lys 
145                 150                 155                 160 


His Leu Ser Asp Ser Glu Gln Arg Glu Val Ala Lys Leu Ile Tyr Glu 
                165                 170                 175     


Met Asp Asp Asp Ala Arg Asp Glu Phe Leu Gly Leu Thr Pro Arg Phe 
            180                 185                 190         


Trp Thr Gln Gly Ser Phe Gln Tyr Asp Thr Leu Asn Arg Pro Phe Gln 
        195                 200                 205             


Pro Gly Gln Glu Met Asp Ile Asp Asp Gly Thr Tyr Met Pro Met Pro 
    210                 215                 220                 


Ile Phe Glu Ser Glu Pro Lys Ile Gly His Ser Leu Leu Ile Leu Leu 
225                 230                 235                 240 


Val Asp Ala Ser Leu Lys Ser Leu Val Ala Glu Asn His Gly Trp Lys 
                245                 250                 255     


Phe Glu Ala Lys Gln Thr Cys Gly Arg Ile Lys Ile Glu Ala Glu Lys 
            260                 265                 270         


Thr His Ile Asp Val Pro Met Tyr Ala Ile Pro Lys Asp Glu Phe Gln 
        275                 280                 285             


Lys Lys Gln Ile Ala Leu Glu Ala Asn Arg Ser Phe Val Lys Gly Ala 
    290                 295                 300                 


Ile Phe Glu Ser Tyr Val Ala Asp Ser Ile Thr Asp Asp Ser Glu Thr 
305                 310                 315                 320 


Tyr Glu Leu Asp Ser Glu Asn Val Asn Leu Ala Leu Arg Glu Gly Asp 
                325                 330                 335     


Arg Lys Trp Ile Asn Ser Asp Pro Lys Ile Val Glu Asp Trp Phe Asn 
            340                 345                 350         


Asp Ser Cys Ile Arg Ile Gly Lys His Leu Arg Lys Val Cys Arg Phe 
        355                 360                 365             


Met Lys Ala Trp Arg Asp Ala Gln Trp Asp Val Gly Gly Pro Ser Ser 
    370                 375                 380                 


Ile Ser Leu Met Ala Ala Thr Val Asn Ile Leu Asp Ser Val Ala His 
385                 390                 395                 400 


Asp Ala Ser Asp Leu Gly Glu Thr Met Lys Ile Ile Ala Lys His Leu 
                405                 410                 415     


Pro Ser Glu Phe Ala Arg Gly Val Glu Ser Pro Asp Ser Thr Asp Glu 
            420                 425                 430         


Lys Pro Leu Phe Pro Pro Ser Tyr Lys His Gly Pro Arg Glu Met Asp 
        435                 440                 445             


Ile Met Ser Lys Leu Glu Arg Leu Pro Glu Ile Leu Ser Ser Ala Glu 
    450                 455                 460                 


Ser Ala Asp Ser Lys Ser Glu Ala Leu Lys Lys Ile Asn Met Ala Phe 
465                 470                 475                 480 


Gly Asn Arg Val Thr Asn Ser Glu Leu Ile Val Leu Ala Lys Ala Leu 
                485                 490                 495     


Pro Ala Phe Ala Gln Glu 
            500         


<210>  12
<211>  365
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Glu Glu Asn Lys Gln Arg Val Lys Ser Met Ile Asn Ile Leu Gln 
1               5                   10                  15      


Leu Val Ala Pro Gly Thr Pro Leu Arg Glu Gly Ile Asp Asn Val Leu 
            20                  25                  30          


Arg Ala Gln Thr Gly Gly Leu Ile Val Leu Gly Tyr Asn Glu Gln Ile 
        35                  40                  45              


Lys Ser Ile Val Asp Gly Gly Phe His Ile Asn Cys Ala Phe Ser Pro 
    50                  55                  60                  


Ala Ser Leu Tyr Glu Leu Ala Lys Met Asp Gly Ala Leu Ile Leu Asn 
65                  70                  75                  80  


Glu Thr Gly Ser Lys Ile Leu Ile Ala Asn Ala Gln Leu Val Pro Asp 
                85                  90                  95      


Ser Ser Ile Asp Ser Ile Glu Thr Gly Met Arg His Arg Thr Ala Glu 
            100                 105                 110         


Arg Val Ala Lys Gln Thr Gly Ser Leu Val Val Ala Ile Ser Gln Arg 
        115                 120                 125             


Arg Asn Val Ile Thr Leu Tyr Gln Gly Asn Leu Arg Tyr Thr Leu Lys 
    130                 135                 140                 


Asp Ile Gly Val Ile Leu Thr Lys Ala Asn Gln Ala Ile Gln Thr Leu 
145                 150                 155                 160 


Glu Lys Tyr Lys Ala Val Trp Asn Asp Gly Ile Thr Asn Leu Gly Ile 
                165                 170                 175     


Leu Glu Phe Glu Glu Val Val Thr Met Ser Glu Val Val His Val Leu 
            180                 185                 190         


His Ser Val Glu Met Val Leu Arg Ile Lys Asn Glu Ile Leu Ser Tyr 
        195                 200                 205             


Ile His Glu Leu Gly Thr Glu Gly Arg Leu Ile Arg Leu Gln Leu Thr 
    210                 215                 220                 


Glu Leu Leu Ala Asp Leu Glu Ala Glu Ala Ala Leu Leu Ile Lys Asp 
225                 230                 235                 240 


Tyr His Gln Glu Lys Thr Gln Asp His His Gln Ile Leu Lys Lys Leu 
                245                 250                 255     


Gln Asp Leu Ala Asn Thr Gln Leu Leu Glu Asp Ser Asp Leu Val Lys 
            260                 265                 270         


Leu Leu Gly Tyr Pro Gly Gln Thr Ser Leu Glu Glu Ser Val Thr Pro 
        275                 280                 285             


Arg Gly Tyr Arg Ile Thr Ser Lys Ile Ser Arg Val Pro Pro Leu Ile 
    290                 295                 300                 


Ile Glu Asn Leu Ile Asn Arg Phe Lys Thr Leu Gln Gly Val Cys Arg 
305                 310                 315                 320 


Ala Thr Ile Asn Glu Leu Asp Asp Val Glu Gly Ile Gly Glu Val Arg 
                325                 330                 335     


Ala Lys Lys Ile Arg Glu Gly Leu Lys Arg Ile Gln Glu His Leu Tyr 
            340                 345                 350         


Met Ser Arg His Asn Leu Glu His His His His His His 
        355                 360                 365 


